Santee South Carolina Accommodations

Find the perfect hotel in Santee using our hotel guide provided below. Search for the cheapest discounted hotel and motel rates in or near Santee, SC for your upcoming personal or group trip. Discover the most favored Santee South Carolina hotel/motel rooms. Review the Santee hotel list below to find the perfect lodging. We also have a map of the Santee hotels. Coordinating a group? Get Santee Group Hotel Discounts

The Santee center point is around 2 miles from Lake Marion Resort and Marina and 18 miles from Edisto Memorial Gardens.

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Santee Hotels, Motels & Accommodations

Days Inn - Santee
+1-800-230-4134Check Rates
9074 Old Highway Six, Santee, SC 29142
  • Low-priced property
Image of Holiday Inn SanteeHoliday Inn Santee
+1-800-997-5148Check Rates
139 Bradford Blvd., Santee, SC 29142
  • 3.0/5, Average Latest Reviews
  • Midscale Highway property
  • Fitness / Gym is on-site
Photo of Comfort Inn & SuitesComfort Inn & Suites
+1-800-997-5149Check Rates
221 Britain St., Santee, SC 29142
  • 3.5/5, Average Read Reviews
  • Cheap Lake hotel
  • 20 suites in property
Exterior of Quality Inn & SuitesQuality Inn & Suites
+1-800-230-4134Check Rates
8929 Old Number Six Highway, Santee, SC 29142
  • 3.0/5, Average Read Reviews
  • 2 star Highway hotel
  • 153 rooms in property
Exterior of Howard Johnson SanteeHoward Johnson Santee
+1-800-997-5148Check Rates
249 Britain St., Santee, SC 29142
  • 3.0/5, Average Hotel Reviews
  • Low-priced Golf Course property
  • Complimentary breakfast is offered
Image of Whitten InnWhitten Inn - Santee
+1-800-997-5149Check Rates
123 Mall St., Santee, SC 29142
Hampton Inn Santee I 95 in Santee
+1-800-230-4134Check Rates
9060 Old #6 Highway, Santee, SC 29142
  • 4.5/5, Very Good Guest Reviews
  • Midscale Highway property
  • Free comp. breakfast
Exterior of Rodeway Inn SanteeRodeway Inn Santee in Santee
+1-800-997-5148Check Rates
9117 Old Number 6 Highway, Santee, SC 29142
Best Western Plus Santee Inn
+1-800-997-5149Check Rates
9059 Old Number Six Highway, Santee, SC 29142
  • 3-star hotel
Travelodge : 9091 Old Highway 6
+1-800-230-4134Check Rates
9091 Old Highway 6, Santee, SC 29142
  • 2.5/5, Poor Hotel Reviews
  • Low Cost Golf Course property
  • Check-in: 1.00
Econo Lodge in Santee
+1-800-997-5148Check Rates
9112 Old Number 6 Hww., Santee, SC 29142
  • Two-star Highway property
  • Free complimentary breakfast
Peachtree Inn
+1-800-997-5149Check Rates
111 Conners Dr., Saint George, SC 29477
  • 4.5/5, Very Good Recent Reviews
  • Mid-scale Highway property
  • 39 rooms in property
~15.51 Miles from Santee
Sunset Inn Manning : 5932 Alex Highway
+1-800-230-4134Check Rates
5932 Alex Highway, Manning, SC 29102~16.27 Miles from Santee
Hampton Inn : 2822 Paxville Highway
+1-800-997-5148Check Rates
2822 Paxville Highway, Manning, SC 29102
  • 4.5/5, Very Good Reviews
  • Mid-scale Highway property
  • Check-in: 2:00pm
~19.30 Miles from Santee
Quality Inn
+1-800-997-5149Check Rates
3031 Paxville Highway, Manning, SC 29102~19.32 Miles from Santee
Country Inn & Suites
+1-800-230-4134Check Rates
731 Citadel Rd., Orangeburg, SC 29118~19.66 Miles from Santee
Fairfield Inn Orangeburg
+1-800-997-5148Check Rates
663 Citadel, Orangeburg, SC 29118
  • 3.5/5, Average Recent Reviews
  • Mid-scale property
  • Free breakfast available
~20.28 Miles from Santee
Comfort Inn & Suites : 746 Citadel Rd.
+1-800-997-5149Check Rates
746 Citadel Rd., Orangeburg, SC 29118
  • 4.0/5, Very Good Guest Reviews
  • Two star Rural property
  • 3 floors in hotel
~20.37 Miles from Santee
Days Inn in Manning
+1-800-230-4134Check Rates
2825 Paxville Highway, Manning, SC 29102~20.47 Miles from Santee
Image of Southern LodgeSouthern Lodge - Orangeburg
+1-800-997-5148Check Rates
3616 St. Matthews Rd., Orangeburg, SC 29118 Website
  • Two-star Highway property
  • Check in time: 2.00pm
~20.48 Miles from Santee

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