Santee South Carolina Accommodations

Find the perfect hotel in Santee using our hotel guide provided below. Search for the cheapest discounted hotel and motel rates in or near Santee, SC for your upcoming personal or group trip. Discover the most favored Santee South Carolina hotel/motel rooms. Review the Santee hotel list below to find the perfect lodging. We also have a map of the Santee hotels. Coordinating a group? Get Santee Group Hotel Discounts

The Santee center point is around 2 miles from Lake Marion Resort and Marina and 18 miles from Edisto Memorial Gardens.

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Santee Hotels, Motels & Accommodations

Days Inn
+1-800-230-4134Check Rates
9074 Old Highway Six, Santee, SC 29142
  • 2-star property
Exterior of Holiday Inn SanteeHoliday Inn Santee : 139 Bradford Blvd.
+1-800-997-5148Check Rates
139 Bradford Blvd., Santee, SC 29142
Photo of Comfort Inn & SuitesComfort Inn & Suites
+1-800-997-5149Check Rates
221 Britain St., Santee, SC 29142
  • 3.5/5, Average Read Reviews
  • 2 star Lake hotel
  • Free breakfast available
Photo of Quality Inn & SuitesQuality Inn & Suites : 8929 Old Number Six Highway
+1-800-230-4134Check Rates
8929 Old Number Six Highway, Santee, SC 29142
  • 3.0/5, Average Guest Reviews
  • 2 star Highway hotel
  • Hotel has 153 rooms
Image of Howard Johnson SanteeHoward Johnson Santee - Santee
+1-800-997-5148Check Rates
249 Britain St., Santee, SC 29142
  • 3.0/5, Average Review Score
  • 2-star Golf Course property
  • Free complimentary breakfast
Exterior of Whitten InnWhitten Inn in Santee
+1-800-997-5149Check Rates
123 Mall St., Santee, SC 29142
Hampton Inn Santee I 95 - Santee
+1-800-230-4134Check Rates
9060 Old #6 Highway, Santee, SC 29142
  • 4.5/5, Very Good Recent Reviews
  • Midscale Highway hotel
  • 3 floors in property
Exterior of Rodeway Inn SanteeRodeway Inn Santee
+1-800-997-5148Check Rates
9117 Old Number 6 Highway, Santee, SC 29142
  • 3.0/5, Average Review Score
  • Cheap Highway hotel
  • Complimentary breakfast is offered
Best Western Plus Santee Inn
+1-800-997-5149Check Rates
9059 Old Number Six Highway, Santee, SC 29142
  • Three Star hotel
Travelodge - Santee
+1-800-230-4134Check Rates
9091 Old Highway 6, Santee, SC 29142
  • 2.5/5, Poor Hotel Reviews
  • Inexpensive Golf Course property
  • Free comp. breakfast
Econo Lodge
+1-800-997-5148Check Rates
9112 Old Number 6 Hww., Santee, SC 29142
  • 2 star Highway property
  • 37 sleeping rooms in hotel
Peachtree Inn
+1-800-997-5149Check Rates
111 Conners Dr., Saint George, SC 29477
  • 4.5/5, Very Good Latest Reviews
  • Three Star Highway property
  • Check-in: 3.00
~15.51 Miles from Santee
Sunset Inn Manning - Manning
+1-800-230-4134Check Rates
5932 Alex Highway, Manning, SC 29102~16.27 Miles from Santee
Hampton Inn : 2822 Paxville Highway
+1-800-997-5148Check Rates
2822 Paxville Highway, Manning, SC 29102~19.30 Miles from Santee
Quality Inn in Manning
+1-800-997-5149Check Rates
3031 Paxville Highway, Manning, SC 29102~19.32 Miles from Santee
Country Inn & Suites - Orangeburg
+1-800-230-4134Check Rates
731 Citadel Rd., Orangeburg, SC 29118~19.66 Miles from Santee
Fairfield Inn Orangeburg : 663 Citadel
+1-800-997-5148Check Rates
663 Citadel, Orangeburg, SC 29118
  • 3.5/5, Average Guest Reviews
  • Midscale hotel
  • Gym / Fitness Center Available
~20.28 Miles from Santee
Comfort Inn & Suites - Orangeburg
+1-800-997-5149Check Rates
746 Citadel Rd., Orangeburg, SC 29118
  • 4.0/5, Very Good Read Reviews
  • 2-star Rural property
  • 69 rooms in property
~20.37 Miles from Santee
Days Inn : 2825 Paxville Highway
+1-800-230-4134Check Rates
2825 Paxville Highway, Manning, SC 29102~20.47 Miles from Santee
Photo of Southern LodgeSouthern Lodge in Orangeburg
+1-800-997-5148Check Rates
3616 St. Matthews Rd., Orangeburg, SC 29118 Website
  • Economy Highway hotel
  • Check in time: 2.00pm
~20.48 Miles from Santee

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