Santee South Carolina Accommodations

Find the perfect hotel in Santee using our hotel guide provided below. Search for the cheapest discounted hotel and motel rates in or near Santee, SC for your upcoming personal or group trip. Discover the most favored Santee South Carolina hotel/motel rooms. Review the Santee hotel list below to find the perfect lodging. We also have a map of the Santee hotels. Coordinating a group? Get Santee Group Hotel Discounts

The Santee center point is around 2 miles from Lake Marion Resort and Marina and 18 miles from Edisto Memorial Gardens.

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Santee Hotels, Motels & Accommodations

Days Inn
+1-800-230-4134Check Rates
9074 Old Highway Six, Santee, SC 29142
  • Cheap property
Exterior of Holiday Inn SanteeHoliday Inn Santee : 139 Bradford Blvd.
+1-800-997-5148Check Rates
139 Bradford Blvd., Santee, SC 29142
  • 3.0/5, Average Guest Reviews
  • 3-star Highway hotel
  • 4 floors in property
Photo of Comfort Inn & SuitesComfort Inn & Suites in Santee
+1-800-997-5149Check Rates
221 Britain St., Santee, SC 29142
  • 4.0/5, Very Good Reviews
  • Two-star Lake hotel
  • Check-in time: 3:00 PM
Photo of Quality Inn & SuitesQuality Inn & Suites
+1-800-230-4134Check Rates
8929 Old Number Six Highway, Santee, SC 29142
  • 3.0/5, Average Review Score
  • Low Cost Highway hotel
  • Hotel has 2 meeting rooms
Exterior of Howard Johnson SanteeHoward Johnson Santee : 249 Britain St.
+1-800-997-5148Check Rates
249 Britain St., Santee, SC 29142
  • 3.0/5, Average Hotel Reviews
  • Two star Golf Course property
  • Free breakfast available
Exterior of Whitten InnWhitten Inn
+1-800-997-5149Check Rates
123 Mall St., Santee, SC 29142
  • 2.5/5, Poor Hotel Reviews
  • Low priced Highway property
  • 117 rooms in property
Hampton Inn Santee I 95
+1-800-230-4134Check Rates
9060 Old #6 Highway, Santee, SC 29142
  • 4.5/5, Very Good Hotel Reviews
  • 3 star Highway hotel
  • 7 suites in property
Exterior of Rodeway Inn SanteeRodeway Inn Santee - Santee
+1-800-997-5148Check Rates
9117 Old Number 6 Highway, Santee, SC 29142
  • 3.0/5, Average Recent Reviews
  • Two-star Highway property
  • Check in: 02:00 PM
Best Western Plus Santee Inn in Santee
+1-800-997-5149Check Rates
9059 Old Number Six Highway, Santee, SC 29142
  • Three Star property
Travelodge
+1-800-230-4134Check Rates
9091 Old Highway 6, Santee, SC 29142
Econo Lodge
+1-800-997-5148Check Rates
9112 Old Number 6 Hww., Santee, SC 29142
  • 2-star Highway hotel
  • Hotel has 37 rooms
Peachtree Inn - Saint George
+1-800-997-5149Check Rates
111 Conners Dr., Saint George, SC 29477
  • 4.5/5, Very Good Recent Reviews
  • 3 star Highway property
  • Hotel has 39 rooms
~15.51 Miles from Santee
Sunset Inn Manning - Manning
+1-800-230-4134Check Rates
5932 Alex Highway, Manning, SC 29102~16.27 Miles from Santee
Hampton Inn - Manning
+1-800-997-5148Check Rates
2822 Paxville Highway, Manning, SC 29102
  • 4.5/5, Very Good Latest Reviews
  • Three Star Highway hotel
  • 73 sleeping rooms in hotel
~19.30 Miles from Santee
Quality Inn in Manning
+1-800-997-5149Check Rates
3031 Paxville Highway, Manning, SC 29102
  • 3.5/5, Average Reviews
  • Low-priced hotel
~19.32 Miles from Santee
Country Inn & Suites - Orangeburg
+1-800-230-4134Check Rates
731 Citadel Rd., Orangeburg, SC 29118
  • 3.5/5, Average Reviews
  • Economical property
  • Hotel has 28 suites
~19.66 Miles from Santee
Fairfield Inn Orangeburg
+1-800-997-5148Check Rates
663 Citadel, Orangeburg, SC 29118~20.28 Miles from Santee
Comfort Inn & Suites
+1-800-997-5149Check Rates
746 Citadel Rd., Orangeburg, SC 29118
  • 4.0/5, Very Good Guest Reviews
  • Inexpensive Rural property
  • Comp. Breakfast
~20.37 Miles from Santee
Days Inn - Manning
+1-800-230-4134Check Rates
2825 Paxville Highway, Manning, SC 29102~20.47 Miles from Santee
Image of Southern LodgeSouthern Lodge
+1-800-997-5148Check Rates
3616 St. Matthews Rd., Orangeburg, SC 29118 Website
  • Cheap Highway property
  • 43 sleeping rooms in hotel
~20.48 Miles from Santee

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