Santee South Carolina Accommodations

Find the perfect hotel in Santee using our hotel guide provided below. Search for the cheapest discounted hotel and motel rates in or near Santee, SC for your upcoming personal or group trip. Discover the most favored Santee South Carolina hotel/motel rooms. Review the Santee hotel list below to find the perfect lodging. We also have a map of the Santee hotels. Coordinating a group? Get Santee Group Hotel Discounts

The Santee center point is around 2 miles from Lake Marion Resort and Marina and 18 miles from Edisto Memorial Gardens.

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Santee Hotels/Accommodations

Days Inn : 9074 Old Highway Six
+1-800-230-4134Check Rates
9074 Old Highway Six, Santee, SC 29142
  • Low Cost hotel
Image of Holiday Inn Santee Holiday Inn Santee
+1-800-997-5148Check Rates
139 Bradford Blvd., Santee, SC 29142
Exterior of Comfort Inn & Suites Comfort Inn & Suites
+1-800-997-5149Check Rates
221 Britain St., Santee, SC 29142
  • 4.0/5, Very Good Review Score
  • Two star Lake property
  • 61 sleeping rooms in hotel
Exterior of Quality Inn & Suites Quality Inn & Suites : 8929 Old Number Six Highway
+1-800-230-4134Check Rates
8929 Old Number Six Highway, Santee, SC 29142
  • 3.0/5, Average Recent Reviews
  • Low Cost Highway hotel
  • 2 meeting rooms in hotel
Image of Howard Johnson Santee Howard Johnson Santee
+1-800-997-5148Check Rates
249 Britain St., Santee, SC 29142
  • 3.0/5, Average Recent Reviews
  • 2 star Golf Course property
  • Free complimentary breakfast
Image of Whitten Inn Whitten Inn : 123 Mall St.
+1-800-997-5149Check Rates
123 Mall St., Santee, SC 29142
  • 2.5/5, Poor Recent Reviews
  • 2 star Highway property
  • 117 rooms in property
Hampton Inn Santee I 95
+1-800-230-4134Check Rates
9060 Old #6 Highway, Santee, SC 29142
  • 4.5/5, Very Good Latest Reviews
  • Affordable Highway property
  • 81 rooms in property
Best Western Plus Santee Inn : 9059 Old Number Six Highway
+1-800-997-5148Check Rates
9059 Old Number Six Highway, Santee, SC 29142
  • Midscale hotel
Econo Lodge Santee
+1-800-997-5149Check Rates
9112 Old Number 6 Highway, Santee, SC 29142
  • 3.5/5, Average Hotel Reviews
  • Cheap Highway property
  • Complimentary breakfast is offered
Rodeway Inn Santee : 9117 Old Number 6 Highway
+1-800-230-4134Check Rates
9117 Old Number 6 Highway, Santee, SC 29142
  • 3.0/5, Average Recent Reviews
  • Low Cost Highway property
  • Check-in time: 02:00 PM
Travelodge : 9091 Old Highway 6
+1-800-997-5148Check Rates
9091 Old Highway 6, Santee, SC 29142
  • 3.0/5, Average Review Score
  • Inexpensive Golf Course property
  • Check in: 1.00
Peachtree Inn in Saint George
+1-800-997-5149Check Rates
111 Conners Dr., Saint George, SC 29477
  • 4.5/5, Very Good Read Reviews
  • Midscale Highway property
  • 39 rooms in property
~15.51 Miles from Santee
Sunset Inn Manning
+1-800-230-4134Check Rates
5932 Alex Highway, Manning, SC 29102 ~16.27 Miles from Santee
Hampton Inn - Manning
+1-800-997-5148Check Rates
2822 Paxville Highway, Manning, SC 29102
  • 4.5/5, Very Good Recent Reviews
  • Affordable Highway property
  • Check-in: 2:00pm
~19.30 Miles from Santee
Quality Inn
+1-800-997-5149Check Rates
3031 Paxville Highway, Manning, SC 29102
  • 3.5/5, Average Reviews
  • Economical hotel
~19.32 Miles from Santee
Country Inn & Suites in Orangeburg
+1-800-230-4134Check Rates
731 Citadel Rd., Orangeburg, SC 29118
  • 3.5/5, Average Reviews
  • Low priced hotel
  • Hotel has 4 floors
~19.66 Miles from Santee
Fairfield Inn Orangeburg : 663 Citadel
+1-800-997-5148Check Rates
663 Citadel, Orangeburg, SC 29118
  • 3.5/5, Average Review Score
  • 3-star property
  • Fitness / Gym is on-site
~20.28 Miles from Santee
Comfort Inn & Suites : 746 Citadel Rd.
+1-800-997-5149Check Rates
746 Citadel Rd., Orangeburg, SC 29118 Website
  • 4.0/5, Very Good Recent Reviews
  • Economy Rural property
  • 14 suites in property
~20.37 Miles from Santee
Days Inn : 2825 Paxville Highway
+1-800-230-4134Check Rates
2825 Paxville Highway, Manning, SC 29102 ~20.47 Miles from Santee
Southern Lodge : 3616 St. Matthews Rd.
+1-800-997-5148Check Rates
3616 St. Matthews Rd., Orangeburg, SC 29118
  • Two-star Highway property
  • Hotel has a green policy See more
~20.48 Miles from Santee

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