Santee South Carolina Accommodations

Find the perfect hotel in Santee using our hotel guide provided below. Search for the cheapest discounted hotel and motel rates in or near Santee, SC for your upcoming personal or group trip. Discover the most favored Santee South Carolina hotel/motel rooms. Review the Santee hotel list below to find the perfect lodging. We also have a map of the Santee hotels. Coordinating a group? Get Santee Group Hotel Discounts

The Santee center point is around 2 miles from Lake Marion Resort and Marina and 18 miles from Edisto Memorial Gardens.

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Santee Hotels/Motels & Accommodations

Days Inn
+1-800-230-4134Check Rates
9074 Old Highway Six, Santee, SC 29142
  • Economy property
Exterior of Holiday Inn SanteeHoliday Inn Santee
+1-800-997-5148Check Rates
139 Bradford Blvd., Santee, SC 29142
  • 3.0/5, Average Reviews
  • Three Star Highway property
  • Fitness + Health Center
Image of Comfort Inn & SuitesComfort Inn & Suites : 221 Britain St.
+1-800-997-5149Check Rates
221 Britain St., Santee, SC 29142
  • 4.0/5, Very Good Recent Reviews
  • Low-priced Lake property
  • Free breakfast available
Photo of Quality Inn & SuitesQuality Inn & Suites
+1-800-230-4134Check Rates
8929 Old Number Six Highway, Santee, SC 29142
  • 3.0/5, Average Read Reviews
  • Economy Highway hotel
  • 153 rooms in property
Exterior of Howard Johnson SanteeHoward Johnson Santee in Santee
+1-800-997-5148Check Rates
249 Britain St., Santee, SC 29142
  • 3.0/5, Average Recent Reviews
  • Inexpensive Golf Course hotel
  • Complimentary breakfast is offered
Exterior of Whitten InnWhitten Inn
+1-800-997-5149Check Rates
123 Mall St., Santee, SC 29142
  • 2.5/5, Poor Latest Reviews
  • Inexpensive Highway hotel
  • Free comp. breakfast
Hampton Inn Santee I 95
+1-800-230-4134Check Rates
9060 Old #6 Highway, Santee, SC 29142
  • 4.5/5, Very Good Recent Reviews
  • 3 star Highway property
  • 81 sleeping rooms in hotel
Image of Econo Lodge SanteeEcono Lodge Santee
+1-800-997-5148Check Rates
9112 Old Number 6 Highway, Santee, SC 29142
  • 3.5/5, Average Guest Reviews
  • 2 star Highway hotel
  • Hotel has 37 rooms
Rodeway Inn Santee
+1-800-997-5149Check Rates
9117 Old Number 6 Highway, Santee, SC 29142
  • 3.0/5, Average Hotel Reviews
  • 2 star Highway hotel
  • Check-in time: 02:00 PM
Best Western Plus Santee Inn
+1-800-230-4134Check Rates
9059 Old Number Six Highway, Santee, SC 29142
  • 3-star property
Travelodge
+1-800-997-5148Check Rates
9091 Old Highway 6, Santee, SC 29142
  • 3.0/5, Average Review Score
  • Two star Golf Course property
  • Free comp. breakfast
Peachtree Inn
+1-800-997-5149Check Rates
111 Conners Dr., Saint George, SC 29477
  • 4.5/5, Very Good Reviews
  • Midscale Highway property
  • Comp. Breakfast
~15.51 Miles from Santee
Sunset Inn Manning in Manning
+1-800-230-4134Check Rates
5932 Alex Highway, Manning, SC 29102~16.27 Miles from Santee
Hampton Inn : 2822 Paxville Highway
+1-800-997-5148Check Rates
2822 Paxville Highway, Manning, SC 29102
  • 4.5/5, Very Good Hotel Reviews
  • Affordable Highway hotel
  • 73 sleeping rooms in hotel
~19.30 Miles from Santee
Quality Inn - Manning
+1-800-997-5149Check Rates
3031 Paxville Highway, Manning, SC 29102~19.32 Miles from Santee
Country Inn & Suites in Orangeburg
+1-800-230-4134Check Rates
731 Citadel Rd., Orangeburg, SC 29118~19.66 Miles from Santee
Fairfield Inn Orangeburg - Orangeburg
+1-800-997-5148Check Rates
663 Citadel, Orangeburg, SC 29118
  • 3.5/5, Average Reviews
  • Three Star property
  • Complimentary breakfast is offered
~20.28 Miles from Santee
Comfort Inn & Suites
+1-800-997-5149Check Rates
746 Citadel Rd., Orangeburg, SC 29118 Website
  • 4.0/5, Very Good Guest Reviews
  • Inexpensive Rural hotel
  • Complimentary breakfast is offered
~20.37 Miles from Santee
Days Inn : 2825 Paxville Highway
+1-800-230-4134Check Rates
2825 Paxville Highway, Manning, SC 29102
  • 2.5/5, Poor Reviews
  • Economy property
~20.47 Miles from Santee
Southern Lodge
+1-800-997-5148Check Rates
3616 St. Matthews Rd., Orangeburg, SC 29118
  • Economical Highway property
  • 43 rooms in property
~20.48 Miles from Santee

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