HOTELS in Santee

Hotels in Santee SC & Motels in Santee South Carolina

Find the perfect hotel in Santee using our hotel guide provided below. Search for the cheapest discounted hotel and motel rates in or near Santee, SC for your upcoming personal or group trip. Discover the most favored Santee South Carolina hotel/motel rooms. Review the Santee hotel list below to find the perfect lodging. We also have a map of the Santee hotels. Coordinating a group? Get Santee Group Hotel Discounts

The Santee center point is around 2 miles from Lake Marion Resort and Marina and 18 miles from Edisto Memorial Gardens.

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Santee Hotels, Motels & Accommodations

Days Inn in Santee
+1-800-230-4134Check Rates
9074 Old Highway Six, Santee, SC 29142
  • 2 star hotel
Image of Holiday Inn SanteeHoliday Inn Santee
+1-800-997-5148Check Rates
139 Bradford Blvd., Santee, SC 29142
  • 3.0/5, Average Review Score
  • Affordable Highway hotel
  • Check in: 4:00pm
Exterior of Comfort Inn & SuitesComfort Inn & Suites
+1-800-997-5149Check Rates
221 Britain St., Santee, SC 29142
  • 4.0/5, Very Good Latest Reviews
  • Two-star Lake hotel
  • Check-in time: 3:00 PM
Photo of Quality Inn & SuitesQuality Inn & Suites : 8929 Old Number Six Highway
+1-800-230-4134Check Rates
8929 Old Number Six Highway, Santee, SC 29142
  • 3.0/5, Average Read Reviews
  • Economy Highway property
  • Free breakfast available
Photo of Howard Johnson SanteeHoward Johnson Santee : 249 Britain St.
+1-800-997-5148Check Rates
249 Britain St., Santee, SC 29142
  • 3.5/5, Average Hotel Reviews
  • Low priced Golf Course property
  • 60 sleeping rooms in hotel
Photo of Whitten InnWhitten Inn
+1-800-997-5149Check Rates
123 Mall St., Santee, SC 29142
  • 2.5/5, Poor Reviews
  • Cheap Highway hotel
  • Check in: 2:00 pm
Hampton Inn Santee I 95
+1-800-230-4134Check Rates
9060 Old #6 Highway, Santee, SC 29142
  • 4.5/5, Very Good Read Reviews
  • 3-star Highway property
  • 81 rooms in hotel
Photo of Econo Lodge SanteeEcono Lodge Santee in Santee
+1-800-997-5148Check Rates
9112 Old Number 6 Highway, Santee, SC 29142
  • 3.5/5, Average Review Score
  • Two-star Highway hotel
  • Check in time: 02:00 PM
Rodeway Inn Santee - Santee
+1-800-997-5149Check Rates
9117 Old Number 6 Highway, Santee, SC 29142
  • 3.0/5, Average Recent Reviews
  • Inexpensive Highway hotel
  • Free comp. breakfast
Best Western Plus Santee Inn - Santee
+1-800-230-4134Check Rates
9059 Old Number Six Highway, Santee, SC 29142
  • Affordable property
Travelodge : 9091 Old Highway 6
+1-800-997-5148Check Rates
9091 Old Highway 6, Santee, SC 29142
  • 3.0/5, Average Recent Reviews
  • Economical Golf Course property
  • Free comp. breakfast
Peachtree Inn
+1-800-997-5149Check Rates
111 Conners Dr., Saint George, SC 29477
  • 4.5/5, Very Good Review Score
  • Mid-scale Highway property
  • Check-in: 3.00
~15.51 Miles from Santee
Sunset Inn Manning in Manning
+1-800-230-4134Check Rates
5932 Alex Highway, Manning, SC 29102~16.27 Miles from Santee
Hampton Inn
+1-800-997-5148Check Rates
2822 Paxville Highway, Manning, SC 29102
  • 4.5/5, Very Good Reviews
  • 3-star Highway hotel
  • Access to gym on-site
~19.30 Miles from Santee
Quality Inn : 3031 Paxville Highway
+1-800-997-5149Check Rates
3031 Paxville Highway, Manning, SC 29102
  • 3.5/5, Average Reviews
  • Economy property
~19.32 Miles from Santee
Country Inn & Suites
+1-800-230-4134Check Rates
731 Citadel Rd., Orangeburg, SC 29118~19.66 Miles from Santee
Fairfield Inn Orangeburg - Orangeburg
+1-800-997-5148Check Rates
663 Citadel, Orangeburg, SC 29118
  • 3.5/5, Average Guest Reviews
  • Mid-scale property
  • Free comp. breakfast
~20.28 Miles from Santee
Comfort Inn & Suites
+1-800-997-5149Check Rates
746 Citadel Rd., Orangeburg, SC 29118 Website
  • 4.0/5, Very Good Guest Reviews
  • Two star Rural property
  • 3 floors in property
~20.37 Miles from Santee
Days Inn in Manning
+1-800-230-4134Check Rates
2825 Paxville Highway, Manning, SC 29102
  • 2.5/5, Poor Reviews
  • Low-priced hotel
~20.47 Miles from Santee
Sleep Inn Orangeburg - Orangeburg
+1-800-997-5148Check Rates
3689 Saint Matthews Rd., Orangeburg, SC 29118
  • 3.5/5, Average Reviews
  • Low-priced Suburban property
  • Comp. Breakfast
~20.49 Miles from Santee

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