Santee South Carolina Accommodations

Find the perfect hotel in Santee using our hotel guide provided below. Search for the cheapest discounted hotel and motel rates in or near Santee, SC for your upcoming personal or group trip. Discover the most favored Santee South Carolina hotel/motel rooms. Review the Santee hotel list below to find the perfect lodging. We also have a map of the Santee hotels. Coordinating a group? Get Santee Group Hotel Discounts

The Santee center point is around 2 miles from Lake Marion Resort and Marina and 18 miles from Edisto Memorial Gardens.

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Santee Hotels & Accommodations

Days Inn
+1-800-230-4134Check Rates
9074 Old Highway Six, Santee, SC 29142
  • Two star property
Photo of Holiday Inn SanteeHoliday Inn Santee
+1-800-997-5148Check Rates
139 Bradford Blvd., Santee, SC 29142
  • 3.0/5, Average Reviews
  • Midscale Highway hotel
  • Fitness center on property
Photo of Comfort Inn & SuitesComfort Inn & Suites : 221 Britain St.
+1-800-997-5149Check Rates
221 Britain St., Santee, SC 29142
  • 4.0/5, Very Good Read Reviews
  • 2-star Lake hotel
  • Hotel has 3 floors
Image of Quality Inn & SuitesQuality Inn & Suites in Santee
+1-800-230-4134Check Rates
8929 Old Number Six Highway, Santee, SC 29142
  • 3.0/5, Average Hotel Reviews
  • Two-star Highway property
  • Hotel has 2 meeting rooms
Image of Howard Johnson SanteeHoward Johnson Santee in Santee
+1-800-997-5148Check Rates
249 Britain St., Santee, SC 29142
  • 3.0/5, Average Review Score
  • Inexpensive Golf Course property
  • 60 rooms in property
Image of Whitten InnWhitten Inn
+1-800-997-5149Check Rates
123 Mall St., Santee, SC 29142
  • 2.5/5, Poor Reviews
  • Economical Highway property
  • Free breakfast available
Hampton Inn Santee I 95
+1-800-230-4134Check Rates
9060 Old #6 Highway, Santee, SC 29142
  • 4.5/5, Very Good Latest Reviews
  • 3 star Highway hotel
  • 7 suites in property
Image of Econo Lodge SanteeEcono Lodge Santee in Santee
+1-800-997-5148Check Rates
9112 Old Number 6 Highway, Santee, SC 29142
Rodeway Inn Santee in Santee
+1-800-997-5149Check Rates
9117 Old Number 6 Highway, Santee, SC 29142
  • 3.0/5, Average Hotel Reviews
  • Economy Highway property
  • Check-in time: 02:00 PM
Best Western Plus Santee Inn in Santee
+1-800-230-4134Check Rates
9059 Old Number Six Highway, Santee, SC 29142
  • Three Star hotel
Travelodge in Santee
+1-800-997-5148Check Rates
9091 Old Highway 6, Santee, SC 29142
  • 3.0/5, Average Reviews
  • Low Cost Golf Course hotel
  • Check in time: 1.00
Peachtree Inn in Saint George
+1-800-997-5149Check Rates
111 Conners Dr., Saint George, SC 29477
  • 4.5/5, Very Good Hotel Reviews
  • 3-star Highway hotel
  • Free complimentary breakfast
~15.51 Miles from Santee
Sunset Inn Manning
+1-800-230-4134Check Rates
5932 Alex Highway, Manning, SC 29102~16.27 Miles from Santee
Hampton Inn
+1-800-997-5148Check Rates
2822 Paxville Highway, Manning, SC 29102
  • 4.5/5, Very Good Guest Reviews
  • Midscale Highway property
  • 3 floors in hotel
~19.30 Miles from Santee
Quality Inn - Manning
+1-800-997-5149Check Rates
3031 Paxville Highway, Manning, SC 29102~19.32 Miles from Santee
Country Inn & Suites
+1-800-230-4134Check Rates
731 Citadel Rd., Orangeburg, SC 29118~19.66 Miles from Santee
Fairfield Inn Orangeburg in Orangeburg
+1-800-997-5148Check Rates
663 Citadel, Orangeburg, SC 29118
  • 3.0/5, Average Reviews
  • Midscale hotel
  • Check-in: 3:00 PM
~20.28 Miles from Santee
Comfort Inn & Suites
+1-800-997-5149Check Rates
746 Citadel Rd., Orangeburg, SC 29118 Website
  • 4.0/5, Very Good Latest Reviews
  • Low priced Rural hotel
  • Hotel has 14 suites
~20.37 Miles from Santee
Days Inn
+1-800-230-4134Check Rates
2825 Paxville Highway, Manning, SC 29102~20.47 Miles from Santee
Photo of Southern LodgeSouthern Lodge
+1-800-997-5148Check Rates
3616 St. Matthews Rd., Orangeburg, SC 29118 Website
  • Low-priced Highway property
  • Check-in time: 2.00pm
~20.48 Miles from Santee

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