Santee South Carolina Accommodations

Find the perfect hotel in Santee using our hotel guide provided below. Search for the cheapest discounted hotel and motel rates in or near Santee, SC for your upcoming personal or group trip. Discover the most favored Santee South Carolina hotel/motel rooms. Review the Santee hotel list below to find the perfect lodging. We also have a map of the Santee hotels. Coordinating a group? Get Santee Group Hotel Discounts

The Santee center point is around 2 miles from Lake Marion Resort and Marina and 18 miles from Edisto Memorial Gardens.

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Santee Hotels/Accommodations

Days Inn - Santee
+1-800-230-4134Check Rates
9074 Old Highway Six, Santee, SC 29142
  • Economical property
Photo of Holiday Inn SanteeHoliday Inn Santee
+1-800-997-5148Check Rates
139 Bradford Blvd., Santee, SC 29142
  • 3.0/5, Average Recent Reviews
  • 3 star Highway property
  • 84 rooms in property
Image of Comfort Inn & SuitesComfort Inn & Suites in Santee
+1-800-997-5149Check Rates
221 Britain St., Santee, SC 29142
  • 4.0/5, Very Good Guest Reviews
  • 2-star Lake property
  • Check in time: 3:00 PM
Image of Quality Inn & SuitesQuality Inn & Suites - Santee
+1-800-230-4134Check Rates
8929 Old Number Six Highway, Santee, SC 29142
  • 3.0/5, Average Guest Reviews
  • Low priced Highway property
  • Free breakfast available
Photo of Howard Johnson SanteeHoward Johnson Santee - Santee
+1-800-997-5148Check Rates
249 Britain St., Santee, SC 29142
  • 3.5/5, Average Read Reviews
  • Low Cost Golf Course hotel
  • Hotel has 60 rooms
Image of Whitten InnWhitten Inn
+1-800-997-5149Check Rates
123 Mall St., Santee, SC 29142
Hampton Inn Santee I 95 in Santee
+1-800-230-4134Check Rates
9060 Old #6 Highway, Santee, SC 29142
  • 4.5/5, Very Good Guest Reviews
  • Affordable Highway property
  • Hotel has 81 rooms
Image of Econo Lodge SanteeEcono Lodge Santee
+1-800-997-5148Check Rates
9112 Old Number 6 Highway, Santee, SC 29142
Rodeway Inn Santee : 9117 Old Number 6 Highway
+1-800-997-5149Check Rates
9117 Old Number 6 Highway, Santee, SC 29142
  • 3.0/5, Average Read Reviews
  • Inexpensive Highway hotel
  • Free breakfast
Best Western Plus Santee Inn
+1-800-230-4134Check Rates
9059 Old Number Six Highway, Santee, SC 29142
  • 3 star hotel
Travelodge
+1-800-997-5148Check Rates
9091 Old Highway 6, Santee, SC 29142
  • 3.0/5, Average Read Reviews
  • Low Cost Golf Course property
  • Check-in: 1.00
Peachtree Inn - Saint George
+1-800-997-5149Check Rates
111 Conners Dr., Saint George, SC 29477
  • 4.5/5, Very Good Review Score
  • Three Star Highway property
  • 39 rooms in property
~15.51 Miles from Santee
Sunset Inn Manning - Manning
+1-800-230-4134Check Rates
5932 Alex Highway, Manning, SC 29102~16.27 Miles from Santee
Hampton Inn
+1-800-997-5148Check Rates
2822 Paxville Highway, Manning, SC 29102
  • 4.5/5, Very Good Reviews
  • 3 star Highway hotel
  • 73 rooms in hotel
~19.30 Miles from Santee
Quality Inn - Manning
+1-800-997-5149Check Rates
3031 Paxville Highway, Manning, SC 29102~19.32 Miles from Santee
Country Inn & Suites - Orangeburg
+1-800-230-4134Check Rates
731 Citadel Rd., Orangeburg, SC 29118
  • 3.5/5, Average Read Reviews
  • 2-star property
  • Hotel has 81 rooms
~19.66 Miles from Santee
Fairfield Inn Orangeburg
+1-800-997-5148Check Rates
663 Citadel, Orangeburg, SC 29118
  • 3.5/5, Average Review Score
  • Affordable hotel
  • Check in time: 3:00 PM
~20.28 Miles from Santee
Comfort Inn & Suites : 746 Citadel Rd.
+1-800-997-5149Check Rates
746 Citadel Rd., Orangeburg, SC 29118 Website
  • 4.0/5, Very Good Read Reviews
  • 2 star Rural property
  • Check-in: 3 pm
~20.37 Miles from Santee
Days Inn : 2825 Paxville Highway
+1-800-230-4134Check Rates
2825 Paxville Highway, Manning, SC 29102~20.47 Miles from Santee
Sleep Inn Orangeburg
+1-800-997-5148Check Rates
3689 Saint Matthews Rd., Orangeburg, SC 29118
  • 3.5/5, Average Review Score
  • Inexpensive Suburban property
  • Check in time: 2:00 PM
~20.49 Miles from Santee

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