Santee South Carolina Accommodations

Find the perfect hotel in Santee using our hotel guide provided below. Search for the cheapest discounted hotel and motel rates in or near Santee, SC for your upcoming personal or group trip. Discover the most favored Santee South Carolina hotel/motel rooms. Review the Santee hotel list below to find the perfect lodging. We also have a map of the Santee hotels. Coordinating a group? Get Santee Group Hotel Discounts

The Santee center point is around 2 miles from Lake Marion Resort and Marina and 18 miles from Edisto Memorial Gardens.

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Santee Hotels & Accommodations

Days Inn - Santee
+1-800-230-4134Check Rates
9074 Old Highway Six, Santee, SC 29142
  • Inexpensive property
Photo of Holiday Inn SanteeHoliday Inn Santee in Santee
+1-800-997-5148Check Rates
139 Bradford Blvd., Santee, SC 29142
  • 3.0/5, Average Hotel Reviews
  • 3-star Highway property
  • 84 sleeping rooms in hotel
Image of Comfort Inn & SuitesComfort Inn & Suites in Santee
+1-800-997-5149Check Rates
221 Britain St., Santee, SC 29142
  • 4.0/5, Very Good Latest Reviews
  • Cheap Lake property
  • 61 sleeping rooms in hotel
Image of Quality Inn & SuitesQuality Inn & Suites : 8929 Old Number Six Highway
+1-800-230-4134Check Rates
8929 Old Number Six Highway, Santee, SC 29142
  • 3.0/5, Average Guest Reviews
  • Economy Highway hotel
  • 2 floors in hotel
Image of Howard Johnson SanteeHoward Johnson Santee in Santee
+1-800-997-5148Check Rates
249 Britain St., Santee, SC 29142
  • 3.0/5, Average Hotel Reviews
  • Two-star Golf Course property
  • Free breakfast
Image of Whitten InnWhitten Inn
+1-800-997-5149Check Rates
123 Mall St., Santee, SC 29142
  • 2.5/5, Poor Reviews
  • Low Cost Highway hotel
  • Hotel has 2 floors
Hampton Inn Santee I 95 : 9060 Old #6 Highway
+1-800-230-4134Check Rates
9060 Old #6 Highway, Santee, SC 29142
  • 4.5/5, Very Good Guest Reviews
  • Affordable Highway hotel
  • 7 suites in hotel
Exterior of Econo Lodge SanteeEcono Lodge Santee in Santee
+1-800-997-5148Check Rates
9112 Old Number 6 Highway, Santee, SC 29142
  • 3.5/5, Average Reviews
  • Low-priced Highway hotel
  • Check in: 02:00 PM
Rodeway Inn Santee
+1-800-997-5149Check Rates
9117 Old Number 6 Highway, Santee, SC 29142
  • 3.0/5, Average Review Score
  • Economy Highway property
  • Check in: 02:00 PM
Best Western Plus Santee Inn
+1-800-230-4134Check Rates
9059 Old Number Six Highway, Santee, SC 29142
  • Midscale hotel
Travelodge - Santee
+1-800-997-5148Check Rates
9091 Old Highway 6, Santee, SC 29142
  • 3.0/5, Average Latest Reviews
  • 2-star Golf Course hotel
  • Free comp. breakfast
Peachtree Inn
+1-800-997-5149Check Rates
111 Conners Dr., Saint George, SC 29477
  • 4.5/5, Very Good Read Reviews
  • Three Star Highway property
  • Hotel has 39 rooms
~15.51 Miles from Santee
Sunset Inn Manning : 5932 Alex Highway
+1-800-230-4134Check Rates
5932 Alex Highway, Manning, SC 29102~16.27 Miles from Santee
Hampton Inn in Manning
+1-800-997-5148Check Rates
2822 Paxville Highway, Manning, SC 29102
  • 4.5/5, Very Good Guest Reviews
  • 3 star Highway property
  • 3 floors in hotel
~19.30 Miles from Santee
Quality Inn in Manning
+1-800-997-5149Check Rates
3031 Paxville Highway, Manning, SC 29102~19.32 Miles from Santee
Country Inn & Suites - Orangeburg
+1-800-230-4134Check Rates
731 Citadel Rd., Orangeburg, SC 29118
  • 3.5/5, Average Hotel Reviews
  • Two-star property
  • 81 sleeping rooms in hotel
~19.66 Miles from Santee
Fairfield Inn Orangeburg
+1-800-997-5148Check Rates
663 Citadel, Orangeburg, SC 29118~20.28 Miles from Santee
Comfort Inn & Suites
+1-800-997-5149Check Rates
746 Citadel Rd., Orangeburg, SC 29118 Website
  • 4.0/5, Very Good Latest Reviews
  • Low Cost Rural property
  • 14 suites in property
~20.37 Miles from Santee
Days Inn
+1-800-230-4134Check Rates
2825 Paxville Highway, Manning, SC 29102~20.47 Miles from Santee
Photo of Southern LodgeSouthern Lodge : 3616 St. Matthews Rd.
+1-800-997-5148Check Rates
3616 St. Matthews Rd., Orangeburg, SC 29118 Website
  • Inexpensive Highway property
  • Hotel has a green policy Learn more
~20.48 Miles from Santee

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