Santee South Carolina Accommodations

Find the perfect hotel in Santee using our hotel guide provided below. Search for the cheapest discounted hotel and motel rates in or near Santee, SC for your upcoming personal or group trip. Discover the most favored Santee South Carolina hotel/motel rooms. Review the Santee hotel list below to find the perfect lodging. We also have a map of the Santee hotels. Coordinating a group? Get Santee Group Hotel Discounts

The Santee center point is around 2 miles from Lake Marion Resort and Marina and 18 miles from Edisto Memorial Gardens.

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Santee Hotels & Accommodations

Days Inn - Santee
+1-800-230-4134Check Rates
9074 Old Highway Six, Santee, SC 29142
  • 2-star hotel
Exterior of Holiday Inn SanteeHoliday Inn Santee
+1-800-997-5148Check Rates
139 Bradford Blvd., Santee, SC 29142
  • 3.0/5, Average Latest Reviews
  • Affordable Highway hotel
  • Gym is available on property
Photo of Comfort Inn & SuitesComfort Inn & Suites - Santee
+1-800-997-5149Check Rates
221 Britain St., Santee, SC 29142
  • 3.5/5, Average Recent Reviews
  • Cheap Lake property
  • Check in time: 3:00 PM
Photo of Quality Inn & SuitesQuality Inn & Suites
+1-800-230-4134Check Rates
8929 Old Number Six Highway, Santee, SC 29142
  • 3.0/5, Average Review Score
  • Low-priced Highway property
  • Free comp. breakfast
Photo of Howard Johnson SanteeHoward Johnson Santee in Santee
+1-800-997-5148Check Rates
249 Britain St., Santee, SC 29142
  • 3.0/5, Average Read Reviews
  • Two star Golf Course property
  • 60 rooms in hotel
Photo of Whitten InnWhitten Inn
+1-800-997-5149Check Rates
123 Mall St., Santee, SC 29142
  • 2.5/5, Poor Recent Reviews
  • Low priced Highway hotel
  • Hotel has 3 meeting rooms
Hampton Inn Santee I 95 - Santee
+1-800-230-4134Check Rates
9060 Old #6 Highway, Santee, SC 29142
  • 4.5/5, Very Good Reviews
  • Mid-scale Highway property
  • Hotel has 7 suites
Photo of Rodeway Inn SanteeRodeway Inn Santee
+1-800-997-5148Check Rates
9117 Old Number 6 Highway, Santee, SC 29142
  • 3.0/5, Average Reviews
  • Low Cost Highway hotel
  • Check-in time: 02:00 PM
Best Western Plus Santee Inn
+1-800-997-5149Check Rates
9059 Old Number Six Highway, Santee, SC 29142
  • Midscale property
Travelodge
+1-800-230-4134Check Rates
9091 Old Highway 6, Santee, SC 29142
  • 2.5/5, Poor Review Score
  • Two-star Golf Course hotel
  • Hotel has 40 rooms
Econo Lodge
+1-800-997-5148Check Rates
9112 Old Number 6 Hww., Santee, SC 29142
  • Two star Highway hotel
  • Hotel has 37 rooms
Peachtree Inn : 111 Conners Dr.
+1-800-997-5149Check Rates
111 Conners Dr., Saint George, SC 29477~15.51 Miles from Santee
Sunset Inn Manning - Manning
+1-800-230-4134Check Rates
5932 Alex Highway, Manning, SC 29102~16.27 Miles from Santee
Hampton Inn
+1-800-997-5148Check Rates
2822 Paxville Highway, Manning, SC 29102
  • 4.5/5, Very Good Hotel Reviews
  • Midscale Highway hotel
  • Free breakfast available
~19.30 Miles from Santee
Quality Inn in Manning
+1-800-997-5149Check Rates
3031 Paxville Highway, Manning, SC 29102~19.32 Miles from Santee
Country Inn & Suites - Orangeburg
+1-800-230-4134Check Rates
731 Citadel Rd., Orangeburg, SC 29118
  • 3.5/5, Average Recent Reviews
  • Low priced property
  • Free complimentary breakfast
~19.66 Miles from Santee
Fairfield Inn Orangeburg
+1-800-997-5148Check Rates
663 Citadel, Orangeburg, SC 29118
  • 3.5/5, Average Hotel Reviews
  • Affordable property
  • Hotel has 3 floors
~20.28 Miles from Santee
Comfort Inn & Suites - Orangeburg
+1-800-997-5149Check Rates
746 Citadel Rd., Orangeburg, SC 29118
  • 4.0/5, Very Good Review Score
  • Cheap Rural property
  • 14 suites in property
~20.37 Miles from Santee
Days Inn - Manning
+1-800-230-4134Check Rates
2825 Paxville Highway, Manning, SC 29102~20.47 Miles from Santee
Exterior of Southern LodgeSouthern Lodge - Orangeburg
+1-800-997-5148Check Rates
3616 St. Matthews Rd., Orangeburg, SC 29118 Website
  • Two-star Highway hotel
  • Has environment-friendly policy See policy
~20.48 Miles from Santee

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