Santee South Carolina Accommodations

Find the perfect hotel in Santee using our hotel guide provided below. Search for the cheapest discounted hotel and motel rates in or near Santee, SC for your upcoming personal or group trip. Discover the most favored Santee South Carolina hotel/motel rooms. Review the Santee hotel list below to find the perfect lodging. We also have a map of the Santee hotels. Coordinating a group? Get Santee Group Hotel Discounts

The Santee center point is around 2 miles from Lake Marion Resort and Marina and 18 miles from Edisto Memorial Gardens.

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Santee Hotels/Motels & Accommodations

Days Inn : 9074 Old Highway Six
+1-800-230-4134Check Rates
9074 Old Highway Six, Santee, SC 29142
  • 2 star hotel
Photo of Holiday Inn SanteeHoliday Inn Santee - Santee
+1-800-997-5148Check Rates
139 Bradford Blvd., Santee, SC 29142
  • 3.0/5, Average Guest Reviews
  • Mid-scale Highway property
  • Hotel has 4 floors
Image of Comfort Inn & SuitesComfort Inn & Suites in Santee
+1-800-997-5149Check Rates
221 Britain St., Santee, SC 29142
  • 4.0/5, Very Good Review Score
  • Economy Lake property
  • 61 rooms in hotel
Photo of Quality Inn & SuitesQuality Inn & Suites : 8929 Old Number Six Highway
+1-800-230-4134Check Rates
8929 Old Number Six Highway, Santee, SC 29142
  • 3.0/5, Average Read Reviews
  • Cheap Highway property
  • 153 sleeping rooms in hotel
Exterior of Howard Johnson SanteeHoward Johnson Santee - Santee
+1-800-997-5148Check Rates
249 Britain St., Santee, SC 29142
  • 3.0/5, Average Review Score
  • Two star Golf Course hotel
  • Check-in time: 03:00pm
Exterior of Whitten InnWhitten Inn
+1-800-997-5149Check Rates
123 Mall St., Santee, SC 29142
Hampton Inn Santee I 95
+1-800-230-4134Check Rates
9060 Old #6 Highway, Santee, SC 29142
  • 4.5/5, Very Good Review Score
  • 3-star Highway property
  • Free breakfast
Exterior of Rodeway Inn SanteeRodeway Inn Santee : 9117 Old Number 6 Highway
+1-800-997-5148Check Rates
9117 Old Number 6 Highway, Santee, SC 29142
  • 3.0/5, Average Reviews
  • 2-star Highway property
  • Check-in: 02:00 PM
Best Western Plus Santee Inn : 9059 Old Number Six Highway
+1-800-997-5149Check Rates
9059 Old Number Six Highway, Santee, SC 29142
  • Three Star hotel
Travelodge - Santee
+1-800-230-4134Check Rates
9091 Old Highway 6, Santee, SC 29142
  • 3.0/5, Average Latest Reviews
  • Economy Golf Course property
  • Free breakfast
Econo Lodge in Santee
+1-800-997-5148Check Rates
9112 Old Number 6 Hww., Santee, SC 29142
  • Two-star Highway hotel
  • Check-in time: 02:00 PM
Peachtree Inn - Saint George
+1-800-997-5149Check Rates
111 Conners Dr., Saint George, SC 29477
  • 4.5/5, Very Good Reviews
  • Midscale Highway hotel
  • 39 rooms in property
~15.51 Miles from Santee
Sunset Inn Manning
+1-800-230-4134Check Rates
5932 Alex Highway, Manning, SC 29102~16.27 Miles from Santee
Hampton Inn in Manning
+1-800-997-5148Check Rates
2822 Paxville Highway, Manning, SC 29102
  • 4.5/5, Very Good Latest Reviews
  • Three Star Highway property
  • Gym is available on property
~19.30 Miles from Santee
Quality Inn - Manning
+1-800-997-5149Check Rates
3031 Paxville Highway, Manning, SC 29102~19.32 Miles from Santee
Country Inn & Suites : 731 Citadel Rd.
+1-800-230-4134Check Rates
731 Citadel Rd., Orangeburg, SC 29118
  • 3.5/5, Average Read Reviews
  • Economical property
  • 81 rooms in hotel
~19.66 Miles from Santee
Fairfield Inn Orangeburg - Orangeburg
+1-800-997-5148Check Rates
663 Citadel, Orangeburg, SC 29118
  • 3.0/5, Average Review Score
  • Mid-scale property
  • 60 sleeping rooms in hotel
~20.28 Miles from Santee
Comfort Inn & Suites : 746 Citadel Rd.
+1-800-997-5149Check Rates
746 Citadel Rd., Orangeburg, SC 29118 Website
  • 4.0/5, Very Good Latest Reviews
  • Economy Rural property
  • Gym is available on property
~20.37 Miles from Santee
Days Inn : 2825 Paxville Highway
+1-800-230-4134Check Rates
2825 Paxville Highway, Manning, SC 29102~20.47 Miles from Santee
Exterior of Southern LodgeSouthern Lodge
+1-800-997-5148Check Rates
3616 St. Matthews Rd., Orangeburg, SC 29118 Website
  • 2-star Highway hotel
  • 43 rooms in hotel
~20.48 Miles from Santee

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