HOTELS in Santee

Hotels in Santee SC & Motels in Santee South Carolina

Find the perfect hotel in Santee using our hotel guide provided below. Search for the cheapest discounted hotel and motel rates in or near Santee, SC for your upcoming personal or group trip. Discover the most favored Santee South Carolina hotel/motel rooms. Review the Santee hotel list below to find the perfect lodging. We also have a map of the Santee hotels. Coordinating a group? Get Santee Group Hotel Discounts

The Santee center point is around 2 miles from Lake Marion Resort and Marina and 18 miles from Edisto Memorial Gardens.

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Santee Hotels, Motels & Accommodations

Days Inn
+1-800-230-4134Check Rates
9074 Old Highway Six, Santee, SC 29142
  • Cheap hotel
Image of Holiday Inn SanteeHoliday Inn Santee
+1-800-997-5148Check Rates
139 Bradford Blvd., Santee, SC 29142
Photo of Comfort Inn & SuitesComfort Inn & Suites : 221 Britain St.
+1-800-997-5149Check Rates
221 Britain St., Santee, SC 29142
  • 4.0/5, Very Good Guest Reviews
  • Two star Lake property
  • 20 suites in hotel
Photo of Quality Inn & SuitesQuality Inn & Suites : 8929 Old Number Six Highway
+1-800-230-4134Check Rates
8929 Old Number Six Highway, Santee, SC 29142
  • 3.0/5, Average Review Score
  • Low Cost Highway property
  • 2 floors in property
Exterior of Howard Johnson SanteeHoward Johnson Santee : 249 Britain St.
+1-800-997-5148Check Rates
249 Britain St., Santee, SC 29142
  • 3.5/5, Average Guest Reviews
  • Economical Golf Course hotel
  • Check in: 03:00pm
Image of Whitten InnWhitten Inn
+1-800-997-5149Check Rates
123 Mall St., Santee, SC 29142
  • 2.5/5, Poor Recent Reviews
  • Inexpensive Highway hotel
  • 3 meeting rooms in property
Hampton Inn Santee I 95 - Santee
+1-800-230-4134Check Rates
9060 Old #6 Highway, Santee, SC 29142
  • 4.5/5, Very Good Hotel Reviews
  • 3-star Highway hotel
  • Check-in time: 3:00 pm
Photo of Rodeway Inn SanteeRodeway Inn Santee - Santee
+1-800-997-5148Check Rates
9117 Old Number 6 Highway, Santee, SC 29142
  • 3.0/5, Average Reviews
  • Two-star Highway property
  • Check in time: 02:00 PM
Econo Lodge Santee - Santee
+1-800-997-5149Check Rates
9112 Old Number 6 Highway, Santee, SC 29142
  • 3.5/5, Average Review Score
  • Cheap Highway property
  • Comp. Breakfast
Best Western Plus Santee Inn
+1-800-230-4134Check Rates
9059 Old Number Six Highway, Santee, SC 29142
  • Three Star property
Travelodge
+1-800-997-5148Check Rates
9091 Old Highway 6, Santee, SC 29142
  • 3.0/5, Average Recent Reviews
  • Inexpensive Golf Course property
  • 40 rooms in property
Peachtree Inn : 111 Conners Dr.
+1-800-997-5149Check Rates
111 Conners Dr., Saint George, SC 29477
  • 4.5/5, Very Good Reviews
  • 3-star Highway property
  • Check in: 3.00
~15.51 Miles from Santee
Sunset Inn Manning in Manning
+1-800-230-4134Check Rates
5932 Alex Highway, Manning, SC 29102~16.27 Miles from Santee
Hampton Inn : 2822 Paxville Highway
+1-800-997-5148Check Rates
2822 Paxville Highway, Manning, SC 29102
  • 4.5/5, Very Good Guest Reviews
  • Affordable Highway hotel
  • Hotel has 3 floors
~19.30 Miles from Santee
Quality Inn - Manning
+1-800-997-5149Check Rates
3031 Paxville Highway, Manning, SC 29102~19.32 Miles from Santee
Country Inn & Suites
+1-800-230-4134Check Rates
731 Citadel Rd., Orangeburg, SC 29118~19.66 Miles from Santee
Fairfield Inn Orangeburg in Orangeburg
+1-800-997-5148Check Rates
663 Citadel, Orangeburg, SC 29118
  • 3.5/5, Average Read Reviews
  • Three Star property
  • 3 floors in hotel
~20.28 Miles from Santee
Comfort Inn & Suites
+1-800-997-5149Check Rates
746 Citadel Rd., Orangeburg, SC 29118 Website
  • 4.0/5, Very Good Read Reviews
  • Low-priced Rural hotel
  • Check-in time: 3 pm
~20.37 Miles from Santee
Days Inn
+1-800-230-4134Check Rates
2825 Paxville Highway, Manning, SC 29102
  • 2.5/5, Poor Reviews
  • Inexpensive property
~20.47 Miles from Santee
Sleep Inn Orangeburg
+1-800-997-5148Check Rates
3689 Saint Matthews Rd., Orangeburg, SC 29118
  • 3.5/5, Average Read Reviews
  • 2-star Suburban hotel
  • Check in: 2:00 PM
~20.49 Miles from Santee

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