Santee South Carolina Accommodations

Find the perfect hotel in Santee using our hotel guide provided below. Search for the cheapest discounted hotel and motel rates in or near Santee, SC for your upcoming personal or group trip. Discover the most favored Santee South Carolina hotel/motel rooms. Review the Santee hotel list below to find the perfect lodging. We also have a map of the Santee hotels. Coordinating a group? Get Santee Group Hotel Discounts

The Santee center point is around 2 miles from Lake Marion Resort and Marina and 18 miles from Edisto Memorial Gardens.

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Santee Hotels/Accommodations

Days Inn
+1-800-230-4134Check Rates
9074 Old Highway Six, Santee, SC 29142
  • Economical hotel
Exterior of Holiday Inn Santee Holiday Inn Santee
+1-800-997-5148Check Rates
139 Bradford Blvd., Santee, SC 29142
  • 3.0/5, Average Recent Reviews
  • Midscale Highway property
  • 84 rooms in hotel
Photo of Comfort Inn & Suites Comfort Inn & Suites
+1-800-997-5149Check Rates
221 Britain St., Santee, SC 29142
  • 4.0/5, Very Good Latest Reviews
  • Economical Lake property
  • 3 floors in hotel
Image of Quality Inn & Suites Quality Inn & Suites in Santee
+1-800-230-4134Check Rates
8929 Old Number Six Highway, Santee, SC 29142
  • 3.0/5, Average Latest Reviews
  • Economy Highway hotel
  • Free breakfast available
Photo of Howard Johnson Santee Howard Johnson Santee : 249 Britain St.
+1-800-997-5148Check Rates
249 Britain St., Santee, SC 29142
  • 3.5/5, Average Reviews
  • Inexpensive Golf Course hotel
  • Check-in: 03:00pm
Exterior of Whitten Inn Whitten Inn
+1-800-997-5149Check Rates
123 Mall St., Santee, SC 29142
  • 2.5/5, Poor Guest Reviews
  • Cheap Highway property
  • 3 conference rooms in property
Hampton Inn Santee I 95 in Santee
+1-800-230-4134Check Rates
9060 Old #6 Highway, Santee, SC 29142
  • 4.5/5, Very Good Latest Reviews
  • 3 star Highway hotel
  • Free breakfast available
Best Western Plus Santee Inn in Santee
+1-800-997-5148Check Rates
9059 Old Number Six Highway, Santee, SC 29142
  • Mid-scale hotel
Econo Lodge Santee
+1-800-997-5149Check Rates
9112 Old Number 6 Highway, Santee, SC 29142
  • 3.5/5, Average Reviews
  • 2-star Highway hotel
  • Complimentary breakfast is offered
Rodeway Inn Santee - Santee
+1-800-230-4134Check Rates
9117 Old Number 6 Highway, Santee, SC 29142
  • 3.0/5, Average Guest Reviews
  • Two star Highway hotel
  • Check-in time: 02:00 PM
Travelodge : 9091 Old Highway 6
+1-800-997-5148Check Rates
9091 Old Highway 6, Santee, SC 29142
  • 3.0/5, Average Recent Reviews
  • Cheap Golf Course hotel
  • 40 sleeping rooms in hotel
Peachtree Inn : 111 Conners Dr.
+1-800-997-5149Check Rates
111 Conners Dr., Saint George, SC 29477
  • 4.5/5, Very Good Guest Reviews
  • Mid-scale Highway property
  • 39 sleeping rooms in hotel
~15.51 Miles from Santee
Sunset Inn Manning
+1-800-230-4134Check Rates
5932 Alex Highway, Manning, SC 29102 ~16.27 Miles from Santee
Hampton Inn in Manning
+1-800-997-5148Check Rates
2822 Paxville Highway, Manning, SC 29102
  • 4.5/5, Very Good Hotel Reviews
  • 3-star Highway hotel
  • Hotel has 3 floors
~19.30 Miles from Santee
Quality Inn in Manning
+1-800-997-5149Check Rates
3031 Paxville Highway, Manning, SC 29102 ~19.32 Miles from Santee
Country Inn & Suites : 731 Citadel Rd.
+1-800-230-4134Check Rates
731 Citadel Rd., Orangeburg, SC 29118 ~19.66 Miles from Santee
Fairfield Inn Orangeburg - Orangeburg
+1-800-997-5148Check Rates
663 Citadel, Orangeburg, SC 29118
  • 3.5/5, Average Review Score
  • Affordable property
  • Hotel has 60 rooms
~20.28 Miles from Santee
Comfort Inn & Suites - Orangeburg
+1-800-997-5149Check Rates
746 Citadel Rd., Orangeburg, SC 29118 Website
  • 4.0/5, Very Good Read Reviews
  • 2 star Rural property
  • 69 rooms in property
~20.37 Miles from Santee
Days Inn - Manning
+1-800-230-4134Check Rates
2825 Paxville Highway, Manning, SC 29102 ~20.47 Miles from Santee
Sleep Inn Orangeburg in Orangeburg
+1-800-997-5148Check Rates
3689 Saint Matthews Rd., Orangeburg, SC 29118
  • 3.5/5, Average Reviews
  • Low-priced Suburban hotel
  • Check-in time: 2:00 PM
~20.49 Miles from Santee

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