Santee South Carolina Accommodations

Find the perfect hotel in Santee using our hotel guide provided below. Search for the cheapest discounted hotel and motel rates in or near Santee, SC for your upcoming personal or group trip. Discover the most favored Santee South Carolina hotel/motel rooms. Review the Santee hotel list below to find the perfect lodging. We also have a map of the Santee hotels. Coordinating a group? Get Santee Group Hotel Discounts

The Santee center point is around 2 miles from Lake Marion Resort and Marina and 18 miles from Edisto Memorial Gardens.

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Santee Hotels, Motels & Accommodations

Days Inn
+1-800-230-4134Check Rates
9074 Old Highway Six, Santee, SC 29142
  • Cheap property
Photo of Holiday Inn SanteeHoliday Inn Santee
+1-800-997-5148Check Rates
139 Bradford Blvd., Santee, SC 29142
  • 3.0/5, Average Hotel Reviews
  • 3-star Highway property
  • Hotel has 4 floors
Photo of Comfort Inn & SuitesComfort Inn & Suites : 221 Britain St.
+1-800-997-5149Check Rates
221 Britain St., Santee, SC 29142
  • 3.5/5, Average Guest Reviews
  • Inexpensive Lake property
  • 20 suites in property
Image of Quality Inn & SuitesQuality Inn & Suites
+1-800-230-4134Check Rates
8929 Old Number Six Highway, Santee, SC 29142
  • 3.0/5, Average Review Score
  • Economical Highway property
  • 2 meeting rooms in hotel
Photo of Howard Johnson SanteeHoward Johnson Santee - Santee
+1-800-997-5148Check Rates
249 Britain St., Santee, SC 29142
  • 3.0/5, Average Latest Reviews
  • Economical Golf Course property
  • Check in time: 03:00pm
Exterior of Whitten InnWhitten Inn
+1-800-997-5149Check Rates
123 Mall St., Santee, SC 29142
  • 2.5/5, Poor Read Reviews
  • Cheap Highway hotel
  • Check in time: 2:00 pm
Hampton Inn Santee I 95
+1-800-230-4134Check Rates
9060 Old #6 Highway, Santee, SC 29142
  • 4.5/5, Very Good Guest Reviews
  • Midscale Highway property
  • Check-in: 3:00 pm
Best Western Plus Santee Inn - Santee
+1-800-997-5148Check Rates
9059 Old Number Six Highway, Santee, SC 29142
  • Midscale hotel
Rodeway Inn Santee : 9117 Old Number 6 Highway
+1-800-997-5149Check Rates
9117 Old Number 6 Highway, Santee, SC 29142
Travelodge
+1-800-230-4134Check Rates
9091 Old Highway 6, Santee, SC 29142
  • 2.5/5, Poor Hotel Reviews
  • Economical Golf Course property
  • Check in: 1.00
Econo Lodge - Santee
+1-800-997-5148Check Rates
9112 Old Number 6 Hww., Santee, SC 29142
  • Low Cost Highway hotel
  • 37 rooms in property
Peachtree Inn : 111 Conners Dr.
+1-800-997-5149Check Rates
111 Conners Dr., Saint George, SC 29477
  • 4.5/5, Very Good Latest Reviews
  • 3-star Highway property
  • Complimentary breakfast is offered
~15.51 Miles from Santee
Sunset Inn Manning in Manning
+1-800-230-4134Check Rates
5932 Alex Highway, Manning, SC 29102~16.27 Miles from Santee
Hampton Inn
+1-800-997-5148Check Rates
2822 Paxville Highway, Manning, SC 29102
  • 4.5/5, Very Good Review Score
  • 3-star Highway property
  • 3 floors in hotel
~19.30 Miles from Santee
Quality Inn : 3031 Paxville Highway
+1-800-997-5149Check Rates
3031 Paxville Highway, Manning, SC 29102~19.32 Miles from Santee
Country Inn & Suites : 731 Citadel Rd.
+1-800-230-4134Check Rates
731 Citadel Rd., Orangeburg, SC 29118
  • 3.5/5, Average Read Reviews
  • Two star property
  • Hotel has 4 floors
~19.66 Miles from Santee
Fairfield Inn Orangeburg
+1-800-997-5148Check Rates
663 Citadel, Orangeburg, SC 29118
  • 3.5/5, Average Latest Reviews
  • Affordable hotel
  • Free complimentary breakfast
~20.28 Miles from Santee
Comfort Inn & Suites
+1-800-997-5149Check Rates
746 Citadel Rd., Orangeburg, SC 29118
  • 4.0/5, Very Good Latest Reviews
  • Two-star Rural hotel
  • Hotel has 14 suites
~20.37 Miles from Santee
Days Inn in Manning
+1-800-230-4134Check Rates
2825 Paxville Highway, Manning, SC 29102~20.47 Miles from Santee
Image of Southern LodgeSouthern Lodge in Orangeburg
+1-800-997-5148Check Rates
3616 St. Matthews Rd., Orangeburg, SC 29118 Website
  • Low Cost Highway hotel
  • Hotel has 43 rooms
~20.48 Miles from Santee

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