Santee South Carolina Accommodations

Find the perfect hotel in Santee using our hotel guide provided below. Search for the cheapest discounted hotel and motel rates in or near Santee, SC for your upcoming personal or group trip. Discover the most favored Santee South Carolina hotel/motel rooms. Review the Santee hotel list below to find the perfect lodging. We also have a map of the Santee hotels. Coordinating a group? Get Santee Group Hotel Discounts

The Santee center point is around 2 miles from Lake Marion Resort and Marina and 18 miles from Edisto Memorial Gardens.

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Santee Hotels & Accommodations

Days Inn - Santee
+1-800-230-4134Check Rates
9074 Old Highway Six, Santee, SC 29142
  • Cheap property
Photo of Holiday Inn SanteeHoliday Inn Santee
+1-800-997-5148Check Rates
139 Bradford Blvd., Santee, SC 29142
  • 3.0/5, Average Review Score
  • Midscale Highway hotel
  • 4 floors in hotel
Image of Comfort Inn & SuitesComfort Inn & Suites : 221 Britain St.
+1-800-997-5149Check Rates
221 Britain St., Santee, SC 29142
  • 3.5/5, Average Reviews
  • Economical Lake hotel
  • Hotel has 20 suites
Photo of Quality Inn & SuitesQuality Inn & Suites in Santee
+1-800-230-4134Check Rates
8929 Old Number Six Highway, Santee, SC 29142
  • 3.0/5, Average Guest Reviews
  • 2 star Highway property
  • Check-in: 3:00PM
Image of Howard Johnson SanteeHoward Johnson Santee
+1-800-997-5148Check Rates
249 Britain St., Santee, SC 29142
  • 3.0/5, Average Review Score
  • Two-star Golf Course hotel
  • Check-in: 03:00pm
Image of Whitten InnWhitten Inn - Santee
+1-800-997-5149Check Rates
123 Mall St., Santee, SC 29142
  • 2.5/5, Poor Read Reviews
  • 2-star Highway hotel
  • 117 sleeping rooms in hotel
Hampton Inn Santee I 95 - Santee
+1-800-230-4134Check Rates
9060 Old #6 Highway, Santee, SC 29142
  • 4.5/5, Very Good Latest Reviews
  • Affordable Highway hotel
  • 81 sleeping rooms in hotel
Best Western Plus Santee Inn
+1-800-997-5148Check Rates
9059 Old Number Six Highway, Santee, SC 29142
  • 3-star hotel
Rodeway Inn Santee
+1-800-997-5149Check Rates
9117 Old Number 6 Highway, Santee, SC 29142
  • 3.0/5, Average Reviews
  • Cheap Highway property
  • Complimentary breakfast is offered
Travelodge
+1-800-230-4134Check Rates
9091 Old Highway 6, Santee, SC 29142
  • 2.5/5, Poor Hotel Reviews
  • Two-star Golf Course hotel
  • Free breakfast
Econo Lodge
+1-800-997-5148Check Rates
9112 Old Number 6 Hww., Santee, SC 29142
  • Low-priced Highway property
  • Comp. Breakfast
Peachtree Inn in Saint George
+1-800-997-5149Check Rates
111 Conners Dr., Saint George, SC 29477
  • 4.5/5, Very Good Reviews
  • Three Star Highway property
  • Hotel has 39 rooms
~15.51 Miles from Santee
Sunset Inn Manning in Manning
+1-800-230-4134Check Rates
5932 Alex Highway, Manning, SC 29102~16.27 Miles from Santee
Hampton Inn in Manning
+1-800-997-5148Check Rates
2822 Paxville Highway, Manning, SC 29102
  • 4.5/5, Very Good Review Score
  • Midscale Highway property
  • 3 floors in hotel
~19.30 Miles from Santee
Quality Inn : 3031 Paxville Highway
+1-800-997-5149Check Rates
3031 Paxville Highway, Manning, SC 29102~19.32 Miles from Santee
Country Inn & Suites : 731 Citadel Rd.
+1-800-230-4134Check Rates
731 Citadel Rd., Orangeburg, SC 29118~19.66 Miles from Santee
Fairfield Inn Orangeburg
+1-800-997-5148Check Rates
663 Citadel, Orangeburg, SC 29118~20.28 Miles from Santee
Comfort Inn & Suites in Orangeburg
+1-800-997-5149Check Rates
746 Citadel Rd., Orangeburg, SC 29118
  • 4.0/5, Very Good Review Score
  • Economy Rural property
  • 69 rooms in hotel
~20.37 Miles from Santee
Days Inn in Manning
+1-800-230-4134Check Rates
2825 Paxville Highway, Manning, SC 29102~20.47 Miles from Santee
Photo of Southern LodgeSouthern Lodge
+1-800-997-5148Check Rates
3616 St. Matthews Rd., Orangeburg, SC 29118 Website
  • 2 star Highway property
  • Hotel has 43 rooms
~20.48 Miles from Santee

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