Hotels in 77221 Houston (Texas)

Hotels in 77221 - Houston TX

Only hotels in 77221 zip code are listed below. Search for cheap and discount hotel rates in Houston, TX for your upcoming leisure or conference / group travel. We list the best 77221 hotels and motels so you can review the Houston hotel list below to find the perfect lodging. Hotels in Harris county and area code 713 are also listed.


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77221 Hotels, Motels & Accommodations

Image of Extended Stay America Houston Greenway PlazaExtended Stay America Houston Greenway Plaza
+1-800-230-4134Check Rates
2330 SW Frwy, Houston, TX 77098
  • 3.5/5, Average Hotel Reviews
  • Low priced Downtown hotel
  • Fitness center on property
~1.17 Miles from 77221
Exterior of Hilton University of HoustonHilton University of Houston : 4800 Calhoun Rd.
+1-800-997-5148Check Rates
4800 Calhoun Rd., Houston, TX 77004
  • 4.0/5, Very Good Latest Reviews
  • Expensive Downtown hotel
  • 86 rooms in property
~1.41 Miles from 77221
Image of Mainstay SuitesMainstay Suites : 3134 Old Spanish Trail
+1-800-997-5149Check Rates
3134 Old Spanish Trail, Houston, TX 77054
  • 4.0/5, Very Good Recent Reviews
  • Two-star Convention Center hotel
  • 92 suites in property
~1.49 Miles from 77221
Extended Stay Deluxe Houston Medical Center in Houston
+1-800-230-4134Check Rates
1301 Braeswood Blvd., Houston, TX 77030
  • 3.0/5, Average Guest Reviews
  • Three Star Convention Center property
  • 3 floors in property
~2.52 Miles from 77221
Image of Hotel Zaza HoustonHotel Zaza Houston - Houston
+1-800-997-5148Check Rates
5701 Main St., Houston, TX 77005
  • 4.5/5, Very Good Review Score
  • High-end Downtown property
  • Check in time: 4:00 PM
~2.57 Miles from 77221
Photo of Lexington Hotel Houston Medical CenterLexington Hotel Houston Medical Center
+1-800-997-5149Check Rates
1025 Swanson St., Houston, TX 77030
  • 4.0/5, Very Good Read Reviews
  • Three Star Downtown hotel
  • Free breakfast
~2.74 Miles from 77221
Photo of Houston Marriott Medical Center HotelHouston Marriott Medical Center Hotel
+1-800-230-4134Check Rates
6580 Fannin, Houston, TX 77030
  • 4.0/5, Very Good Read Reviews
  • 4 star Downtown property
  • 14 meeting rooms in hotel
~2.77 Miles from 77221
Image of Hotel IconHotel Icon
+1-800-997-5148Check Rates
220 Main St., Houston, TX 77002
  • High-end Downtown hotel
  • 6 meeting rooms in property
~2.79 Miles from 77221
Houston Marriott at the Texas Medical Center
+1-800-997-5149Check Rates
6580 Fannin Steet, Houston, TX 77030~2.80 Miles from 77221
Hampton Inn & Suites Houston Medical Center : 1715 Old Spanish Trail
+1-800-230-4134Check Rates
1715 Old Spanish Trail, Houston, TX 77054
  • 4.5/5, Very Good Latest Reviews
  • 3-star Convention Center hotel
  • 120 sleeping rooms in hotel
~2.92 Miles from 77221
Best Western Plaza Hotel & Suites Medical Center
+1-800-997-5148Check Rates
6700 South Main St., Houston, TX 77030
  • 3.5/5, Average Hotel Reviews
  • 3-star Downtown hotel
  • 125 rooms in property
~2.92 Miles from 77221
Hilton Houston Plaza / Medical Center - Houston
+1-800-997-5149Check Rates
6633 Travis, Houston, TX 77030
  • 4.0/5, Very Good Read Reviews
  • 4-star Downtown property
  • 9 meeting rooms in hotel
~2.93 Miles from 77221
Robin's Nest Bed & Breakfast Inn - Houston
+1-800-230-4134Check Rates
4104 Greeley St., Houston, TX 77006
  • 4.5/5, Very Good Review Score
  • Low priced Downtown property
  • Hotel has 3 suites
~2.99 Miles from 77221
Wyndham Houston Medical Center Hotel & Suite in Houston
+1-800-997-5148Check Rates
6800 Main St., Houston, TX 77030
  • 4.0/5, Very Good Recent Reviews
  • Midscale Downtown hotel
  • Check in: 3:00PM
~2.99 Miles from 77221
Homestead Studio Suites in Houston
+1-800-997-5149Check Rates
7979 Fannin, Houston, TX 77054
  • Two-star Downtown hotel
  • 153 rooms in property
~3.02 Miles from 77221
Holiday Inn Express & Suites Downtown in Houston
+1-800-230-4134Check Rates
1810 Bell St., Houston, TX 77003
  • 4.0/5, Very Good Latest Reviews
  • 3 star Downtown property
  • Check in: 3:00pm
~3.14 Miles from 77221
Hilton Americas Houston
+1-800-997-5148Check Rates
1600 Lamar, Houston, TX 77010
  • 4.5/5, Very Good Guest Reviews
  • Four-star Downtown hotel
  • 24 floors in hotel
~3.32 Miles from 77221
Springhill Suites Houston Medical Center / Reliant in Houston
+1-800-997-5149Check Rates
1400 Old Spanish Trail, Houston, TX 77054
  • 4.0/5, Very Good Guest Reviews
  • Affordable Downtown hotel
  • Hotel has 190 suites
~3.33 Miles from 77221
Athens Hotel
+1-800-230-4134Check Rates
1308 Clay St., Houston, TX 77002~3.41 Miles from 77221
Courtyard by Marriott Houston Medical Center
+1-800-997-5148Check Rates
Houston Medical Center 7702 Main St., Houston, TX 77030
  • 4.0/5, Very Good Recent Reviews
  • 3 star Suburban property
  • 197 rooms in property
~3.48 Miles from 77221
Holiday Inn Houston Reliant Park Area - Houston
+1-800-997-5149Check Rates
8111 Kirby Dr., Houston, TX 77054
  • 3.5/5, Average Guest Reviews
  • Affordable Suburban hotel
  • 11 floors in hotel
~3.51 Miles from 77221
Extended Stay America Houston Reliant Pk. La Conch
+1-800-230-4134Check Rates
1303 La Concha Ln, Houston, TX 77054
  • 3.0/5, Average Hotel Reviews
  • Affordable Convention Center hotel
  • 45 suites in hotel
~3.52 Miles from 77221
Four Seasons Hotel Houston
+1-800-997-5148Check Rates
1300 Lamar St., Houston, TX 77010
  • 4.5/5, Very Good Reviews
  • Luxurious 5 Star Downtown hotel
  • 14 meeting rooms in hotel
~3.52 Miles from 77221
Moody Manor at the Houston Medical Center
+1-800-997-5149Check Rates
7706 South Main, Houston, TX 77030
  • Economical Downtown property
  • 54 rooms in hotel
~3.53 Miles from 77221
Residence Inn by Marriott Medical Center / Reliant - Houston
+1-800-230-4134Check Rates
7710 Main St., Houston, TX 77030
  • 3.5/5, Average Latest Reviews
  • Mid-scale Highway hotel
  • 2 floors in property
~3.60 Miles from 77221
Rodeway Inn & Suites - Houston
+1-800-997-5148Check Rates
6712 Morningside Dr., Houston, TX 77030
  • 2.0/5, Poor Read Reviews
  • Cheap Downtown property
  • Hotel has 33 rooms
~3.61 Miles from 77221
Photo of Crowne Plaza Houston DowntownCrowne Plaza Houston Downtown - Houston
+1-800-997-5149Check Rates
1700 Smith St., Houston, TX 77002
  • 4.0/5, Very Good Latest Reviews
  • Expensive Downtown hotel
  • 13 meeting rooms in hotel
~3.62 Miles from 77221
Courtyard Houston Downtown in Houston
+1-800-230-4134Check Rates
916 Dallas St., Houston, TX 77002
  • 3.5/5, Average Recent Reviews
  • Affordable Downtown property
  • Check-in: 3:00 PM
~3.64 Miles from 77221
Residence Inn Houston Downtown : 904 Dallas St.
+1-800-997-5148Check Rates
904 Dallas St., Houston, TX 77002
  • 4.0/5, Very Good Read Reviews
  • Affordable Downtown property
  • Fitness / Gym is on-site
~3.64 Miles from 77221
Parkview Inn & Suites
+1-800-997-5149Check Rates
9000 South Main, Houston, TX 77025
  • 2 star hotel
~3.68 Miles from 77221
The Westin Houston Downtown in Houston
+1-800-230-4134Check Rates
1520 Texas Ave., Houston, TX 77002
  • 4.5/5, Very Good Guest Reviews
  • 4-star Downtown property
  • 20 suites in property
~3.71 Miles from 77221
Holiday Inn Express Suites Medical Center
+1-800-997-5148Check Rates
8080 South Main St., Houston, TX 77025
  • 4.0/5, Very Good Reviews
  • Affordable Downtown property
  • 35 suites in hotel
~3.72 Miles from 77221
Hyatt Regency Houston - Houston
+1-800-997-5149Check Rates
1200 Louisiana St., Houston, TX 77002
  • 4.0/5, Very Good Guest Reviews
  • Expensive Downtown property
  • Hotel has 947 rooms
~3.78 Miles from 77221
Comfort Suites
+1-800-230-4134Check Rates
1055 Mcnee Rd., Houston, TX 77054
  • 3.5/5, Average Recent Reviews
  • Two-star Convention Center hotel
  • 50 rooms in property
~3.82 Miles from 77221
Magnolia Hotel - Houston
+1-800-997-5148Check Rates
1100 Texas Ave., Houston, TX 77002
  • 4.5/5, Very Good Hotel Reviews
  • High end Downtown property
  • Hotel has 7 meeting rooms
~3.84 Miles from 77221
Crowne Plaza Houston Near Reliant Medical
+1-800-997-5149Check Rates
8686 Kirby Dr., Houston, TX 77054
  • 3.0/5, Average Latest Reviews
  • Midscale Convention Center property
  • Airport shuttle provided
~3.86 Miles from 77221
Doubletree Houston Downtown
+1-800-230-4134Check Rates
400 Dallas St., Houston, TX 77002
  • 4.0/5, Very Good Guest Reviews
  • Affordable Downtown property
  • 350 sleeping rooms in hotel
~3.89 Miles from 77221
The Sam Houston Hotel - Houston
+1-800-997-5148Check Rates
1117 Prairie St., Houston, TX 77002
  • 4.0/5, Very Good Read Reviews
  • 3 star Downtown property
  • 9 suites in property
~3.91 Miles from 77221
Best Western Downtown Inn & Suites - Houston
+1-800-997-5149Check Rates
915 West Dallas, Houston, TX 77019
  • 4.5/5, Very Good Hotel Reviews
  • 3 star Downtown hotel
  • 50 suites in property
~3.97 Miles from 77221
The Quality Inn & Suites Reliant Park
+1-800-230-4134Check Rates
2364 South Loop West, Houston, TX 77054
  • 3.5/5, Average Read Reviews
  • Mid-scale Convention Center property
  • 106 rooms in property
~3.99 Miles from 77221
The Lancaster Hotel Houston
+1-800-997-5148Check Rates
701 Texas Ave., Houston, TX 77002
  • Expensive Downtown hotel
  • Check in: 3:00 pm
~4.04 Miles from 77221
Crowne Plaza Houston River Oaks
+1-800-997-5149Check Rates
2712 Southwest Fwy, Houston, TX 77098
  • 4.5/5, Very Good Guest Reviews
  • High end Downtown property
  • 18 floors in property
~4.38 Miles from 77221
Four Points by Sheraton Houston Southwest : 2828 Southwest Fwy
+1-800-230-4134Check Rates
2828 Southwest Fwy, Houston, TX 77098
  • 3.0/5, Average Read Reviews
  • 3-star Downtown hotel
  • 4 meeting rooms in property
~4.48 Miles from 77221
Residence Inn : 2939 Westpark Dr.
+1-800-997-5148Check Rates
2939 Westpark Dr., Houston, TX 77005
  • 4.0/5, Very Good Read Reviews
  • Affordable Downtown hotel
  • 4 floors in property
~4.48 Miles from 77221
Courtyard by Marriott Houston West University in Houston
+1-800-997-5149Check Rates
2929 Westpark Dr., Houston, TX 77005
  • 4.0/5, Very Good Latest Reviews
  • Affordable Suburban hotel
  • 2 suites in property
~4.49 Miles from 77221
Greenway Inn & Suites
+1-800-230-4134Check Rates
2929 Southwest Freeway, Houston, TX 77098
  • 1.5/5, Terrible Recent Reviews
  • Low Cost Suburban property
  • 4 floors in property
~4.50 Miles from 77221
La Quinta Inn Reliant / Medical Center - Houston
+1-800-997-5148Check Rates
9911 Buffalo Speedway, Houston, TX 77054
  • 3.5/5, Average Recent Reviews
  • 2-star Downtown hotel
  • 113 rooms in property
~4.54 Miles from 77221
Americas Best Value Inn : 9604 South Main
+1-800-997-5149Check Rates
9604 South Main, Houston, TX 77025
  • 3.5/5, Average Reviews
  • Inexpensive Convention Center property
  • Free comp. breakfast
~4.68 Miles from 77221
Executive Inn & Suites : 6711 Telephone Rd.
+1-800-230-4134Check Rates
6711 Telephone Rd., Houston, TX 77061~4.75 Miles from 77221
Carefree Inn at the Medical Center
+1-800-997-5148Check Rates
10015 South Main St., Houston, TX 77025
  • 4.0/5, Very Good Reviews
  • 2-star Downtown property
  • Shuttle from airport available
~4.76 Miles from 77221



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