Hotels in 77221 Houston (Texas)

Hotels in 77221 - Houston TX

Only hotels in 77221 zip code are listed below. Search for cheap and discount hotel rates in Houston, TX for your upcoming leisure or conference / group travel. We list the best 77221 hotels and motels so you can review the Houston hotel list below to find the perfect lodging. Hotels in Harris county and area code 713 are also listed.


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77221 Hotels, Motels & Accommodations

Exterior of Extended Stay America Houston Greenway Plaza Extended Stay America Houston Greenway Plaza - Houston
+1-800-230-4134Check Rates
2330 SW Frwy, Houston, TX 77098
  • 3.5/5, Average Read Reviews
  • Economical Downtown hotel
  • 122 sleeping rooms in hotel
~1.17 Miles from 77221
Photo of Hilton University of Houston Hilton University of Houston in Houston
+1-800-997-5148Check Rates
4800 Calhoun Rd., Houston, TX 77004
  • 4.0/5, Very Good Reviews
  • 4-star Downtown property
  • Hotel has 8 floors
~1.41 Miles from 77221
Photo of Mainstay Suites Mainstay Suites : 3134 Old Spanish Trail
+1-800-997-5149Check Rates
3134 Old Spanish Trail, Houston, TX 77054
  • 4.0/5, Very Good Reviews
  • Economical Convention Center property
  • Fitness / Gym is on-site
~1.49 Miles from 77221
Extended Stay Deluxe Houston Medical Center
+1-800-230-4134Check Rates
1301 Braeswood Blvd., Houston, TX 77030
  • 3.0/5, Average Recent Reviews
  • 3-star Convention Center property
  • Hotel has 3 floors
~2.52 Miles from 77221
Exterior of Hotel Zaza Houston Hotel Zaza Houston - Houston
+1-800-997-5148Check Rates
5701 Main St., Houston, TX 77005
  • 4.5/5, Very Good Guest Reviews
  • Four-star Downtown hotel
  • Access to gym on-site
~2.57 Miles from 77221
Exterior of Lexington Hotel Houston Medical Center Lexington Hotel Houston Medical Center - Houston
+1-800-997-5149Check Rates
1025 Swanson St., Houston, TX 77030
  • 4.0/5, Very Good Latest Reviews
  • 3-star Downtown property
  • Check in: 3:00 PM
~2.74 Miles from 77221
Image of Houston Marriott Medical Center Hotel Houston Marriott Medical Center Hotel in Houston
+1-800-230-4134Check Rates
6580 Fannin, Houston, TX 77030
  • 4.0/5, Very Good Reviews
  • 4-star Downtown property
  • Check in: 4PM
~2.77 Miles from 77221
Exterior of Hotel Icon Hotel Icon : 220 Main St.
+1-800-997-5148Check Rates
220 Main St., Houston, TX 77002
  • Expensive Downtown property
  • 135 rooms in hotel
~2.79 Miles from 77221
Houston Marriott at the Texas Medical Center
+1-800-997-5149Check Rates
6580 Fannin Steet, Houston, TX 77030 ~2.80 Miles from 77221
Hampton Inn & Suites Houston Medical Center
+1-800-230-4134Check Rates
1715 Old Spanish Trail, Houston, TX 77054
  • 4.5/5, Very Good Read Reviews
  • 3-star Convention Center hotel
  • Check in: 3:00PM
~2.92 Miles from 77221
Best Western Plaza Hotel & Suites Medical Center
+1-800-997-5148Check Rates
6700 South Main St., Houston, TX 77030
  • 3.5/5, Average Reviews
  • 3-star Downtown hotel
  • 125 sleeping rooms in hotel
~2.92 Miles from 77221
Hilton Houston Plaza / Medical Center
+1-800-997-5149Check Rates
6633 Travis, Houston, TX 77030
  • 4.0/5, Very Good Reviews
  • 4 star Downtown property
  • Hotel has 184 rooms
~2.93 Miles from 77221
Robin's Nest Bed & Breakfast Inn
+1-800-230-4134Check Rates
4104 Greeley St., Houston, TX 77006
  • 4.5/5, Very Good Recent Reviews
  • Inexpensive Downtown property
  • Airport shuttle available
~2.99 Miles from 77221
Wyndham Houston Medical Center Hotel & Suite
+1-800-997-5148Check Rates
6800 Main St., Houston, TX 77030
  • 4.0/5, Very Good Hotel Reviews
  • Affordable Downtown hotel
  • Hotel has 215 suites
~2.99 Miles from 77221
Homestead Studio Suites in Houston
+1-800-997-5149Check Rates
7979 Fannin, Houston, TX 77054
  • Cheap Downtown hotel
  • 153 rooms in property
~3.02 Miles from 77221
Holiday Inn Express & Suites Downtown
+1-800-230-4134Check Rates
1810 Bell St., Houston, TX 77003
  • 4.0/5, Very Good Latest Reviews
  • 3-star Downtown property
  • Hotel has 22 suites
~3.14 Miles from 77221
Hilton Americas Houston : 1600 Lamar
+1-800-997-5148Check Rates
1600 Lamar, Houston, TX 77010
  • 4.5/5, Very Good Latest Reviews
  • Expensive Downtown hotel
  • 27 conference rooms in property
~3.32 Miles from 77221
Springhill Suites Houston Medical Center / Reliant
+1-800-997-5149Check Rates
1400 Old Spanish Trail, Houston, TX 77054
  • 4.0/5, Very Good Latest Reviews
  • Affordable Downtown hotel
  • Check-in: 3:00PM
~3.33 Miles from 77221
Athens Hotel - Houston
+1-800-230-4134Check Rates
1308 Clay St., Houston, TX 77002
  • 3.5/5, Average Read Reviews
  • Cheap Downtown property
  • Check in: 2PM
~3.41 Miles from 77221
Courtyard by Marriott Houston Medical Center : Houston Medical Center 7702 Main St.
+1-800-997-5148Check Rates
Houston Medical Center 7702 Main St., Houston, TX 77030
  • 4.0/5, Very Good Guest Reviews
  • Three Star Suburban hotel
  • 3 meeting rooms in hotel
~3.48 Miles from 77221
Holiday Inn Houston Reliant Park Area
+1-800-997-5149Check Rates
8111 Kirby Dr., Houston, TX 77054
  • 3.5/5, Average Latest Reviews
  • Affordable Suburban hotel
  • 3 meeting rooms in property
~3.51 Miles from 77221
Extended Stay America Houston Reliant Pk. La Conch - Houston
+1-800-230-4134Check Rates
1303 La Concha Ln, Houston, TX 77054
  • 3.0/5, Average Guest Reviews
  • Midscale Convention Center hotel
  • Hotel has 84 rooms
~3.52 Miles from 77221
Four Seasons Hotel Houston in Houston
+1-800-997-5148Check Rates
1300 Lamar St., Houston, TX 77010
  • 4.5/5, Very Good Review Score
  • Luxury Five Star Downtown hotel
  • Check in time: 3:00 p.m.
~3.52 Miles from 77221
Moody Manor at the Houston Medical Center
+1-800-997-5149Check Rates
7706 South Main, Houston, TX 77030
  • 2 star Downtown property
~3.53 Miles from 77221
Residence Inn by Marriott Medical Center / Reliant in Houston
+1-800-230-4134Check Rates
7710 Main St., Houston, TX 77030
  • 3.5/5, Average Reviews
  • Midscale Highway property
  • Free breakfast
~3.60 Miles from 77221
Rodeway Inn & Suites : 6712 Morningside Dr.
+1-800-997-5148Check Rates
6712 Morningside Dr., Houston, TX 77030
  • 2.0/5, Poor Recent Reviews
  • Economy Downtown property
  • 2 floors in property
~3.61 Miles from 77221
Photo of Crowne Plaza Houston Downtown Crowne Plaza Houston Downtown : 1700 Smith St.
+1-800-997-5149Check Rates
1700 Smith St., Houston, TX 77002
  • 4.0/5, Very Good Guest Reviews
  • High-end Downtown hotel
  • 259 sleeping rooms in hotel
~3.62 Miles from 77221
Residence Inn Houston Downtown - Houston
+1-800-230-4134Check Rates
904 Dallas St., Houston, TX 77002
  • 4.0/5, Very Good Reviews
  • 3 star Downtown property
  • Fitness / Gym is on-site
~3.64 Miles from 77221
Courtyard Houston Downtown in Houston
+1-800-997-5148Check Rates
916 Dallas St., Houston, TX 77002
  • 3.5/5, Average Recent Reviews
  • Three Star Downtown property
  • 191 sleeping rooms in hotel
~3.64 Miles from 77221
Parkview Inn & Suites
+1-800-997-5149Check Rates
9000 South Main, Houston, TX 77025
  • Low Cost property
~3.68 Miles from 77221
The Westin Houston Downtown : 1520 Texas Ave.
+1-800-230-4134Check Rates
1520 Texas Ave., Houston, TX 77002 ~3.71 Miles from 77221
Holiday Inn Express Suites Medical Center - Houston
+1-800-997-5148Check Rates
8080 South Main St., Houston, TX 77025
  • 4.0/5, Very Good Read Reviews
  • Three Star Downtown property
  • 79 sleeping rooms in hotel
~3.72 Miles from 77221
Hyatt Regency Houston - Houston
+1-800-997-5149Check Rates
1200 Louisiana St., Houston, TX 77002
  • 4.0/5, Very Good Hotel Reviews
  • High-end Downtown property
  • 30 floors in property
~3.78 Miles from 77221
Comfort Suites
+1-800-230-4134Check Rates
1055 Mcnee Rd., Houston, TX 77054
  • 3.5/5, Average Reviews
  • Economical Convention Center hotel
  • 50 sleeping rooms in hotel
~3.82 Miles from 77221
Magnolia Hotel : 1100 Texas Ave.
+1-800-997-5148Check Rates
1100 Texas Ave., Houston, TX 77002
  • 4.5/5, Very Good Read Reviews
  • 4-star Downtown hotel
  • 7 meeting rooms in hotel
~3.84 Miles from 77221
Crowne Plaza Houston Near Reliant Medical : 8686 Kirby Dr.
+1-800-997-5149Check Rates
8686 Kirby Dr., Houston, TX 77054
  • 3.0/5, Average Guest Reviews
  • Three Star Convention Center property
  • Fitness + Health Center
~3.86 Miles from 77221
Doubletree Houston Downtown : 400 Dallas St.
+1-800-230-4134Check Rates
400 Dallas St., Houston, TX 77002
  • 4.0/5, Very Good Read Reviews
  • Midscale Downtown hotel
  • Airport shuttle available
~3.89 Miles from 77221
The Sam Houston Hotel
+1-800-997-5148Check Rates
1117 Prairie St., Houston, TX 77002
  • 4.0/5, Very Good Latest Reviews
  • Mid-scale Downtown hotel
  • Access to gym on-site
~3.91 Miles from 77221
Best Western Downtown Inn & Suites
+1-800-997-5149Check Rates
915 West Dallas, Houston, TX 77019
  • 4.5/5, Very Good Guest Reviews
  • Mid-scale Downtown hotel
  • Hotel has 76 rooms
~3.97 Miles from 77221
The Quality Inn & Suites Reliant Park : 2364 South Loop West
+1-800-230-4134Check Rates
2364 South Loop West, Houston, TX 77054
  • 3.5/5, Average Guest Reviews
  • Midscale Convention Center property
  • Hotel has 21 suites
~3.99 Miles from 77221
The Lancaster Hotel Houston
+1-800-997-5148Check Rates
701 Texas Ave., Houston, TX 77002
  • 4 star Downtown hotel
  • Fitness / Gym is on-site
~4.04 Miles from 77221
Crowne Plaza Houston River Oaks
+1-800-997-5149Check Rates
2712 Southwest Fwy, Houston, TX 77098
  • 4.5/5, Very Good Latest Reviews
  • 4 star Downtown property
  • Hotel has 18 floors
~4.38 Miles from 77221
Four Points by Sheraton Houston Southwest
+1-800-230-4134Check Rates
2828 Southwest Fwy, Houston, TX 77098
  • 3.0/5, Average Reviews
  • 3-star Downtown property
  • Check-in: 3:00 PM
~4.48 Miles from 77221
Residence Inn
+1-800-997-5148Check Rates
2939 Westpark Dr., Houston, TX 77005
  • 4.0/5, Very Good Hotel Reviews
  • 3-star Downtown property
  • Free breakfast available
~4.48 Miles from 77221
Courtyard by Marriott Houston West University
+1-800-997-5149Check Rates
2929 Westpark Dr., Houston, TX 77005
  • 4.0/5, Very Good Hotel Reviews
  • Affordable Suburban property
  • 100 rooms in hotel
~4.49 Miles from 77221
Greenway Inn & Suites
+1-800-230-4134Check Rates
2929 Southwest Freeway, Houston, TX 77098
  • 1.5/5, Terrible Guest Reviews
  • Cheap Suburban property
  • 10 suites in hotel
~4.50 Miles from 77221
La Quinta Inn Reliant / Medical Center - Houston
+1-800-997-5148Check Rates
9911 Buffalo Speedway, Houston, TX 77054
  • 3.5/5, Average Read Reviews
  • Two star Downtown hotel
  • Hotel has 113 rooms
~4.54 Miles from 77221
Americas Best Value Inn - Houston
+1-800-997-5149Check Rates
9604 South Main, Houston, TX 77025
  • 3.5/5, Average Latest Reviews
  • Low-priced Convention Center hotel
  • Hotel has 2 suites
~4.68 Miles from 77221
Executive Inn & Suites : 6711 Telephone Rd.
+1-800-230-4134Check Rates
6711 Telephone Rd., Houston, TX 77061 ~4.75 Miles from 77221
Carefree Inn at the Medical Center : 10015 South Main St.
+1-800-997-5148Check Rates
10015 South Main St., Houston, TX 77025
  • 4.0/5, Very Good Reviews
  • Two-star Downtown property
  • Check-in: 2:00 PM
~4.76 Miles from 77221



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