Hotels in 77221 - Houston TX

Only hotels in 77221 zip code are listed below. Search for cheap and discount hotel rates in Houston, TX for your upcoming leisure or conference / group travel. We list the best 77221 hotels and motels so you can review the Houston hotel list below to find the perfect lodging. Hotels in Harris county and area code 713 are also listed.


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77221 Hotels/Motels & Accommodations

Exterior of Extended Stay America Houston Greenway PlazaExtended Stay America Houston Greenway Plaza in Houston
+1-800-230-4134Check Rates
2330 SW Frwy, Houston, TX 77098
  • 3.5/5, Average Review Score
  • Low Cost Downtown hotel
  • 122 rooms in hotel
~1.17 Miles from 77221
Image of Hilton University of HoustonHilton University of Houston : 4800 Calhoun Rd.
+1-800-997-5148Check Rates
4800 Calhoun Rd., Houston, TX 77004
  • 4.0/5, Very Good Recent Reviews
  • High-end Downtown property
  • Hotel has 8 floors
~1.41 Miles from 77221
Photo of Mainstay SuitesMainstay Suites
+1-800-997-5149Check Rates
3134 Old Spanish Trail, Houston, TX 77054
  • 4.0/5, Very Good Latest Reviews
  • Cheap Convention Center property
  • 92 suites in hotel
~1.49 Miles from 77221
Extended Stay Deluxe Houston Medical Center - Houston
+1-800-230-4134Check Rates
1301 Braeswood Blvd., Houston, TX 77030
  • 3.0/5, Average Latest Reviews
  • Mid-scale Convention Center property
  • Hotel has 130 rooms
~2.52 Miles from 77221
Exterior of Hotel Zaza HoustonHotel Zaza Houston in Houston
+1-800-997-5148Check Rates
5701 Main St., Houston, TX 77005
  • 4.5/5, Very Good Review Score
  • Four star Downtown hotel
  • Check-in time: 4:00 PM
~2.57 Miles from 77221
Photo of Lexington Hotel Houston Medical CenterLexington Hotel Houston Medical Center : 1025 Swanson St.
+1-800-997-5149Check Rates
1025 Swanson St., Houston, TX 77030
  • 4.0/5, Very Good Hotel Reviews
  • 3-star Downtown property
  • 3 floors in property
~2.74 Miles from 77221
Exterior of Houston Marriott Medical Center HotelHouston Marriott Medical Center Hotel : 6580 Fannin
+1-800-230-4134Check Rates
6580 Fannin, Houston, TX 77030
  • 4.0/5, Very Good Review Score
  • High end Downtown property
  • 386 sleeping rooms in hotel
~2.77 Miles from 77221
Exterior of Hotel IconHotel Icon
+1-800-997-5148Check Rates
220 Main St., Houston, TX 77002
  • Four-star Downtown property
  • Check-in time: 03:00 PM
~2.79 Miles from 77221
Houston Marriott at the Texas Medical Center in Houston
+1-800-997-5149Check Rates
6580 Fannin Steet, Houston, TX 77030~2.80 Miles from 77221
Hampton Inn & Suites Houston Medical Center : 1715 Old Spanish Trail
+1-800-230-4134Check Rates
1715 Old Spanish Trail, Houston, TX 77054
  • 4.5/5, Very Good Reviews
  • Three Star Convention Center property
  • Gym / Fitness Center Available
~2.92 Miles from 77221
Hilton Houston Plaza Medical Center in Houston
+1-800-997-5148Check Rates
6633 Travis, Houston, TX 77030
  • 4.0/5, Very Good Reviews
  • Affordable Downtown property
  • Check in: 03:00 PM
~2.93 Miles from 77221
Robin's Nest Bed & Breakfast Inn
+1-800-997-5149Check Rates
4104 Greeley St., Houston, TX 77006
  • Three Star Downtown property
  • 2 meeting rooms in hotel
~2.99 Miles from 77221
Wyndham Houston Medical Center Hotel & Suite : 6800 Main St.
+1-800-230-4134Check Rates
6800 Main St., Houston, TX 77030
  • 4.0/5, Very Good Recent Reviews
  • Affordable Downtown property
  • Check in time: 3:00PM
~2.99 Miles from 77221
Holiday Inn Express & Suites Downtown - Houston
+1-800-997-5148Check Rates
1810 Bell St., Houston, TX 77003
  • 4.0/5, Very Good Latest Reviews
  • 3 star Downtown property
  • Check-in: 3:00pm
~3.14 Miles from 77221
Hilton Americas Houston
+1-800-997-5149Check Rates
1600 Lamar, Houston, TX 77010
  • 4.5/5, Very Good Guest Reviews
  • High-end Downtown property
  • 31 suites in hotel
~3.32 Miles from 77221
Springhill Suites by Marriott Houston Nrg Park
+1-800-230-4134Check Rates
1400 Old Spanish Trail, Houston, TX 77054
  • 3 star Downtown property
  • Free comp. breakfast
~3.33 Miles from 77221
Athens Hotel
+1-800-997-5148Check Rates
1308 Clay St., Houston, TX 77002
  • 3.5/5, Average Hotel Reviews
  • Economical Downtown hotel
  • 23 rooms in property
~3.41 Miles from 77221
Courtyard by Marriott Houston Medical Center in Houston
+1-800-997-5149Check Rates
Houston Medical Center 7702 Main St., Houston, TX 77030
  • 4.0/5, Very Good Recent Reviews
  • Mid-scale Suburban hotel
  • Access to gym on-site
~3.48 Miles from 77221
Holiday Inn Houston Reliant Park Area
+1-800-230-4134Check Rates
8111 Kirby Dr., Houston, TX 77054
  • 3.5/5, Average Reviews
  • Three Star Suburban property
  • 238 sleeping rooms in hotel
~3.51 Miles from 77221
Extended Stay America Houston Reliant Pk. La Conch
+1-800-997-5148Check Rates
1303 La Concha Ln, Houston, TX 77054
  • 3.0/5, Average Hotel Reviews
  • Midscale Convention Center property
  • Hotel has 84 rooms
~3.52 Miles from 77221
Four Seasons Hotel Houston - Houston
+1-800-997-5149Check Rates
1300 Lamar St., Houston, TX 77010
  • 4.5/5, Very Good Reviews
  • Luxurious Five Star Downtown property
  • Hotel has 179 suites
~3.52 Miles from 77221
Moody Manor at the Houston Medical Center in Houston
+1-800-230-4134Check Rates
7706 South Main, Houston, TX 77030
  • Cheap Downtown property
  • Check-in time: 3:00pm
~3.53 Miles from 77221
Residence Inn by Marriott Medical Center / Reliant - Houston
+1-800-997-5148Check Rates
7710 Main St., Houston, TX 77030
  • 3.5/5, Average Guest Reviews
  • 3-star Highway hotel
  • 2 floors in hotel
~3.60 Miles from 77221
Crowne Plaza Houston Downtown
+1-800-997-5149Check Rates
1700 Smith St., Houston, TX 77002
  • 4-star Downtown property
  • Hotel has 19 suites
~3.62 Miles from 77221
Rodeway Inn Suites
+1-800-230-4134Check Rates
6712 Morningside Dr., Houston, TX 77030
  • 2 star Downtown hotel
  • 33 rooms in property
~3.63 Miles from 77221
Courtyard Houston Downtown - Houston
+1-800-997-5148Check Rates
916 Dallas St., Houston, TX 77002
  • 3.5/5, Average Read Reviews
  • 3-star Downtown property
  • Check-in: 3:00 PM
~3.64 Miles from 77221
Residence Inn Houston Downtown in Houston
+1-800-997-5149Check Rates
904 Dallas St., Houston, TX 77002
  • 4.0/5, Very Good Review Score
  • Midscale Downtown property
  • Hotel has 171 suites
~3.64 Miles from 77221
The Westin Houston Downtown - Houston
+1-800-230-4134Check Rates
1520 Texas Ave., Houston, TX 77002
  • 4.5/5, Very Good Read Reviews
  • High-end Downtown hotel
  • Fitness + Health Center
~3.71 Miles from 77221
Holiday Inn Express Suites Medical Center in Houston
+1-800-997-5148Check Rates
8080 South Main St., Houston, TX 77025
  • 4.0/5, Very Good Reviews
  • 3 star Downtown property
  • Hotel has 35 suites
~3.72 Miles from 77221
Hyatt Regency Houston : 1200 Louisiana St.
+1-800-997-5149Check Rates
1200 Louisiana St., Houston, TX 77002
  • 4.0/5, Very Good Guest Reviews
  • High-end Downtown property
  • 22 suites in hotel
~3.78 Miles from 77221
Comfort Suites - Houston
+1-800-230-4134Check Rates
1055 Mcnee Rd., Houston, TX 77054
  • 3.5/5, Average Review Score
  • Two star Convention Center hotel
  • Check in: 3pm
~3.82 Miles from 77221
JW Marriott Houston Downtown in Houston
+1-800-997-5148Check Rates
806 Main, Houston, TX 77002
  • Luxury 5 star hotel
~3.82 Miles from 77221
Magnolia Hotel in Houston
+1-800-997-5149Check Rates
1100 Texas Ave., Houston, TX 77002
  • 4.5/5, Very Good Guest Reviews
  • Four-star Downtown hotel
  • 23 floors in property
~3.84 Miles from 77221
Crowne Plaza Houston Near Reliant Medical in Houston
+1-800-230-4134Check Rates
8686 Kirby Dr., Houston, TX 77054
  • 3.0/5, Average Read Reviews
  • Three Star Convention Center hotel
  • Gym / Fitness Center Available
~3.86 Miles from 77221
Doubletree Houston Downtown
+1-800-997-5148Check Rates
400 Dallas St., Houston, TX 77002
  • 4.0/5, Very Good Reviews
  • Midscale Downtown hotel
  • Hotel has 350 rooms
~3.89 Miles from 77221
The Sam Houston Hotel
+1-800-997-5149Check Rates
1117 Prairie St., Houston, TX 77002
  • 4.0/5, Very Good Review Score
  • High end Downtown hotel
  • Check-in time: 3:00 PM
~3.91 Miles from 77221
Best Western Downtown Inn & Suites in Houston
+1-800-230-4134Check Rates
915 West Dallas, Houston, TX 77019
  • 4.5/5, Very Good Hotel Reviews
  • Midscale Downtown hotel
  • 50 suites in property
~3.97 Miles from 77221
The Quality Inn & Suites Reliant Park in Houston
+1-800-997-5148Check Rates
2364 South Loop West, Houston, TX 77054
  • 3.5/5, Average Recent Reviews
  • Three Star Convention Center hotel
  • Access to gym on-site
~3.99 Miles from 77221
The Lancaster Hotel Houston
+1-800-997-5149Check Rates
701 Texas Ave., Houston, TX 77002
  • Four-star Downtown property
  • 12 floors in property
~4.04 Miles from 77221
Crowne Plaza Houston River Oaks - Houston
+1-800-230-4134Check Rates
2712 Southwest Fwy, Houston, TX 77098
  • 4.5/5, Very Good Guest Reviews
  • Expensive Downtown hotel
  • Fitness / Gym is on-site
~4.38 Miles from 77221
Four Points by Sheraton Houston Southwest in Houston
+1-800-997-5148Check Rates
2828 Southwest Fwy, Houston, TX 77098
  • 3.0/5, Average Guest Reviews
  • Mid-scale Downtown property
  • Gym is available on property
~4.48 Miles from 77221
Residence Inn - Houston
+1-800-997-5149Check Rates
2939 Westpark Dr., Houston, TX 77005
  • 4.0/5, Very Good Review Score
  • 3-star Downtown hotel
  • 120 rooms in hotel
~4.48 Miles from 77221
Courtyard by Marriott Houston West University in Houston
+1-800-230-4134Check Rates
2929 Westpark Dr., Houston, TX 77005
  • 4.0/5, Very Good Latest Reviews
  • 3 star Suburban property
  • 3 floors in hotel
~4.49 Miles from 77221
Greenway Inn & Suites : 2929 Southwest Freeway
+1-800-997-5148Check Rates
2929 Southwest Freeway, Houston, TX 77098
  • 1.5/5, Terrible Latest Reviews
  • Economical Suburban hotel
  • 160 rooms in hotel
~4.50 Miles from 77221
La Quinta Inn Reliant / Medical Center : 9911 Buffalo Speedway
+1-800-997-5149Check Rates
9911 Buffalo Speedway, Houston, TX 77054
  • 3.0/5, Average Reviews
  • Economy Downtown property
  • 113 rooms in hotel
~4.54 Miles from 77221
Americas Best Value Inn : 9604 South Main
+1-800-230-4134Check Rates
9604 South Main, Houston, TX 77025
  • 3.5/5, Average Latest Reviews
  • Economy Convention Center property
  • Free breakfast
~4.68 Miles from 77221
Executive Inn & Suites
+1-800-997-5148Check Rates
6711 Telephone Rd., Houston, TX 77061~4.75 Miles from 77221
Carefree Inn at the Medical Center
+1-800-997-5149Check Rates
10015 South Main St., Houston, TX 77025
  • 4.0/5, Very Good Hotel Reviews
  • Cheap Downtown property
  • Free breakfast available
~4.76 Miles from 77221
Motel 6 Houston Reliant Park #1126
+1-800-230-4134Check Rates
3223 South Loop West, Houston, TX 77025
  • Economy hotel
  • 3 floors in hotel
~4.77 Miles from 77221
Candlewood Suites Houston Medical Center - Houston
+1-800-997-5148Check Rates
10025 South Main St., Houston, TX 77025
  • 4.0/5, Very Good Guest Reviews
  • Cheap Highway hotel
  • 80 rooms in hotel
~4.83 Miles from 77221



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