Hotels in 77221 - Houston TX

Only hotels in 77221 zip code are listed below. Search for cheap and discount hotel rates in Houston, TX for your upcoming leisure or conference / group travel. We list the best 77221 hotels and motels so you can review the Houston hotel list below to find the perfect lodging. Hotels in Harris county and area code 713 are also listed.


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77221 Hotels/Motels & Accommodations

Photo of Extended Stay America Houston Greenway PlazaExtended Stay America Houston Greenway Plaza : 2330 SW Frwy
+1-800-230-4134Check Rates
2330 SW Frwy, Houston, TX 77098
  • 3.5/5, Average Latest Reviews
  • 2 star Downtown property
  • 2 suites in property
~1.17 Miles from 77221
Image of Hilton University of HoustonHilton University of Houston - Houston
+1-800-997-5148Check Rates
4800 Calhoun Rd., Houston, TX 77004
  • 4.0/5, Very Good Review Score
  • High-end Downtown property
  • Hotel has 12 suites
~1.41 Miles from 77221
Photo of Mainstay SuitesMainstay Suites : 3134 Old Spanish Trail
+1-800-997-5149Check Rates
3134 Old Spanish Trail, Houston, TX 77054
  • 4.0/5, Very Good Read Reviews
  • Inexpensive Convention Center property
  • Shuttle from airport available
~1.49 Miles from 77221
Extended Stay Deluxe Houston Medical Center
+1-800-230-4134Check Rates
1301 Braeswood Blvd., Houston, TX 77030
  • 3.0/5, Average Review Score
  • Midscale Convention Center property
  • Complimentary breakfast is offered
~2.52 Miles from 77221
Photo of Hotel Zaza HoustonHotel Zaza Houston
+1-800-997-5148Check Rates
5701 Main St., Houston, TX 77005
  • 4.5/5, Very Good Guest Reviews
  • High-end Downtown property
  • Fitness + Health Center
~2.57 Miles from 77221
Exterior of Lexington Hotel Houston Medical CenterLexington Hotel Houston Medical Center : 1025 Swanson St.
+1-800-997-5149Check Rates
1025 Swanson St., Houston, TX 77030
  • 4.0/5, Very Good Recent Reviews
  • Midscale Downtown property
  • Check-in time: 3:00 PM
~2.74 Miles from 77221
Image of Houston Marriott Medical Center HotelHouston Marriott Medical Center Hotel in Houston
+1-800-230-4134Check Rates
6580 Fannin, Houston, TX 77030
  • 4.0/5, Very Good Hotel Reviews
  • Four-star Downtown hotel
  • 386 rooms in property
~2.77 Miles from 77221
Exterior of Hotel IconHotel Icon in Houston
+1-800-997-5148Check Rates
220 Main St., Houston, TX 77002
  • Four-star Downtown property
  • Hotel has 15 suites
~2.79 Miles from 77221
Houston Marriott at the Texas Medical Center
+1-800-997-5149Check Rates
6580 Fannin Steet, Houston, TX 77030~2.80 Miles from 77221
Hampton Inn & Suites Houston Medical Center : 1715 Old Spanish Trail
+1-800-230-4134Check Rates
1715 Old Spanish Trail, Houston, TX 77054
  • 4.5/5, Very Good Latest Reviews
  • 3 star Convention Center hotel
  • 37 suites in hotel
~2.92 Miles from 77221
Hilton Houston Plaza Medical Center - Houston
+1-800-997-5148Check Rates
6633 Travis, Houston, TX 77030
  • 4.0/5, Very Good Guest Reviews
  • 3-star Downtown hotel
  • 19 floors in property
~2.93 Miles from 77221
Robin's Nest Bed & Breakfast Inn - Houston
+1-800-997-5149Check Rates
4104 Greeley St., Houston, TX 77006
  • 4.5/5, Very Good Hotel Reviews
  • Low Cost Downtown property
  • Airport shuttle available
~2.99 Miles from 77221
Wyndham Houston Medical Center Hotel & Suite
+1-800-230-4134Check Rates
6800 Main St., Houston, TX 77030
  • 4.0/5, Very Good Latest Reviews
  • Affordable Downtown property
  • Check in time: 3:00PM
~2.99 Miles from 77221
Homestead Studio Suites
+1-800-997-5148Check Rates
7979 Fannin, Houston, TX 77054
  • Economical Downtown property
  • 3 floors in property
~3.02 Miles from 77221
Holiday Inn Express & Suites Downtown in Houston
+1-800-997-5149Check Rates
1810 Bell St., Houston, TX 77003
  • 4.0/5, Very Good Latest Reviews
  • Mid-scale Downtown hotel
  • Free comp. breakfast
~3.14 Miles from 77221
Hilton Americas Houston
+1-800-230-4134Check Rates
1600 Lamar, Houston, TX 77010
  • 4.5/5, Very Good Hotel Reviews
  • Four-star Downtown hotel
  • 1200 rooms in property
~3.32 Miles from 77221
Springhill Suites Houston Medical Center / Reliant - Houston
+1-800-997-5148Check Rates
1400 Old Spanish Trail, Houston, TX 77054
  • 4.0/5, Very Good Recent Reviews
  • Midscale Downtown property
  • Check-in time: 3:00PM
~3.33 Miles from 77221
Athens Hotel - Houston
+1-800-997-5149Check Rates
1308 Clay St., Houston, TX 77002
  • 3.5/5, Average Recent Reviews
  • Low priced Downtown property
  • 2 floors in hotel
~3.41 Miles from 77221
Courtyard by Marriott Houston Medical Center
+1-800-230-4134Check Rates
Houston Medical Center 7702 Main St., Houston, TX 77030
  • 4.0/5, Very Good Read Reviews
  • 3 star Suburban hotel
  • Hotel has 8 floors
~3.48 Miles from 77221
Holiday Inn Houston Reliant Park Area - Houston
+1-800-997-5148Check Rates
8111 Kirby Dr., Houston, TX 77054
  • 3.5/5, Average Hotel Reviews
  • Mid-scale Suburban property
  • Check-in: 4:00 PM
~3.51 Miles from 77221
Extended Stay America Houston Reliant Pk. La Conch
+1-800-997-5149Check Rates
1303 La Concha Ln, Houston, TX 77054
  • 3.0/5, Average Hotel Reviews
  • Mid-scale Convention Center property
  • 84 rooms in hotel
~3.52 Miles from 77221
Four Seasons Hotel Houston
+1-800-230-4134Check Rates
1300 Lamar St., Houston, TX 77010
  • 4.5/5, Very Good Read Reviews
  • Luxurious Five Star Downtown hotel
  • Airport shuttle available
~3.52 Miles from 77221
Moody Manor at the Houston Medical Center - Houston
+1-800-997-5148Check Rates
7706 South Main, Houston, TX 77030
  • Economy Downtown hotel
  • 54 sleeping rooms in hotel
~3.53 Miles from 77221
Residence Inn by Marriott Medical Center / Reliant
+1-800-997-5149Check Rates
7710 Main St., Houston, TX 77030
  • 3.5/5, Average Review Score
  • 3 star Highway property
  • 287 suites in property
~3.60 Miles from 77221
Crowne Plaza Houston Downtown in Houston
+1-800-230-4134Check Rates
1700 Smith St., Houston, TX 77002
  • Expensive Downtown property
  • 259 rooms in hotel
~3.62 Miles from 77221
Rodeway Inn Suites : 6712 Morningside Dr.
+1-800-997-5148Check Rates
6712 Morningside Dr., Houston, TX 77030
  • Economical Downtown property
  • Complimentary breakfast is offered
~3.63 Miles from 77221
Residence Inn Houston Downtown - Houston
+1-800-997-5149Check Rates
904 Dallas St., Houston, TX 77002
  • 4.0/5, Very Good Review Score
  • Midscale Downtown property
  • Access to gym on-site
~3.64 Miles from 77221
Courtyard Houston Downtown : 916 Dallas St.
+1-800-230-4134Check Rates
916 Dallas St., Houston, TX 77002
  • 3.5/5, Average Read Reviews
  • Three Star Downtown property
  • 9 floors in property
~3.64 Miles from 77221
Parkview Inn & Suites - Houston
+1-800-997-5148Check Rates
9000 South Main, Houston, TX 77025
  • Low Cost property
~3.68 Miles from 77221
The Westin Houston Downtown - Houston
+1-800-997-5149Check Rates
1520 Texas Ave., Houston, TX 77002
  • 4.5/5, Very Good Guest Reviews
  • 4 star Downtown property
  • Hotel has 200 rooms
~3.71 Miles from 77221
Holiday Inn Express Suites Medical Center
+1-800-230-4134Check Rates
8080 South Main St., Houston, TX 77025
  • 4.0/5, Very Good Reviews
  • 3-star Downtown property
  • Hotel has 79 rooms
~3.72 Miles from 77221
Hyatt Regency Houston : 1200 Louisiana St.
+1-800-997-5148Check Rates
1200 Louisiana St., Houston, TX 77002
  • 4.0/5, Very Good Latest Reviews
  • 4 star Downtown hotel
  • Hotel has 947 rooms
~3.78 Miles from 77221
Comfort Suites in Houston
+1-800-997-5149Check Rates
1055 Mcnee Rd., Houston, TX 77054
  • 3.5/5, Average Latest Reviews
  • Economical Convention Center property
  • Hotel has 50 suites
~3.82 Miles from 77221
Magnolia Hotel
+1-800-230-4134Check Rates
1100 Texas Ave., Houston, TX 77002
  • 4.5/5, Very Good Read Reviews
  • Four-star Downtown hotel
  • 23 floors in hotel
~3.84 Miles from 77221
Crowne Plaza Houston Near Reliant Medical
+1-800-997-5148Check Rates
8686 Kirby Dr., Houston, TX 77054
  • 3.0/5, Average Recent Reviews
  • Three Star Convention Center property
  • 8 floors in property
~3.86 Miles from 77221
Doubletree Houston Downtown - Houston
+1-800-997-5149Check Rates
400 Dallas St., Houston, TX 77002
  • 4.0/5, Very Good Review Score
  • Three Star Downtown property
  • Hotel has 350 rooms
~3.89 Miles from 77221
The Sam Houston Hotel : 1117 Prairie St.
+1-800-230-4134Check Rates
1117 Prairie St., Houston, TX 77002
  • 4.0/5, Very Good Review Score
  • 3 star Downtown hotel
  • Hotel has 100 rooms
~3.91 Miles from 77221
Best Western Downtown Inn & Suites : 915 West Dallas
+1-800-997-5148Check Rates
915 West Dallas, Houston, TX 77019
  • 4.5/5, Very Good Hotel Reviews
  • 3 star Downtown hotel
  • Access to gym on-site
~3.97 Miles from 77221
The Quality Inn & Suites Reliant Park - Houston
+1-800-997-5149Check Rates
2364 South Loop West, Houston, TX 77054
  • 3.5/5, Average Review Score
  • 3 star Convention Center property
  • Check in: 3:00 pm
~3.99 Miles from 77221
The Lancaster Hotel Houston : 701 Texas Ave.
+1-800-230-4134Check Rates
701 Texas Ave., Houston, TX 77002
  • Four-star Downtown property
  • 9 suites in property
~4.04 Miles from 77221
Crowne Plaza Houston River Oaks - Houston
+1-800-997-5148Check Rates
2712 Southwest Fwy, Houston, TX 77098
  • 4.5/5, Very Good Read Reviews
  • High end Downtown hotel
  • Check in: 3:00 PM
~4.38 Miles from 77221
Four Points by Sheraton Houston Southwest - Houston
+1-800-997-5149Check Rates
2828 Southwest Fwy, Houston, TX 77098
  • 3.0/5, Average Latest Reviews
  • Three Star Downtown property
  • Hotel has 216 rooms
~4.48 Miles from 77221
Residence Inn - Houston
+1-800-230-4134Check Rates
2939 Westpark Dr., Houston, TX 77005
  • 4.0/5, Very Good Latest Reviews
  • 3 star Downtown hotel
  • Fitness + Health Center
~4.48 Miles from 77221
Courtyard by Marriott Houston West University
+1-800-997-5148Check Rates
2929 Westpark Dr., Houston, TX 77005
  • 4.0/5, Very Good Reviews
  • Affordable Suburban property
  • 3 floors in property
~4.49 Miles from 77221
Greenway Inn & Suites
+1-800-997-5149Check Rates
2929 Southwest Freeway, Houston, TX 77098
  • 1.5/5, Terrible Hotel Reviews
  • Inexpensive Suburban property
  • Hotel has 160 rooms
~4.50 Miles from 77221
La Quinta Inn Reliant / Medical Center
+1-800-230-4134Check Rates
9911 Buffalo Speedway, Houston, TX 77054
  • 3.5/5, Average Read Reviews
  • Cheap Downtown property
  • Complimentary breakfast is offered
~4.54 Miles from 77221
Americas Best Value Inn in Houston
+1-800-997-5148Check Rates
9604 South Main, Houston, TX 77025
  • 3.5/5, Average Guest Reviews
  • Economy Convention Center property
  • 2 floors in property
~4.68 Miles from 77221
Executive Inn & Suites
+1-800-997-5149Check Rates
6711 Telephone Rd., Houston, TX 77061~4.75 Miles from 77221
Carefree Inn at the Medical Center
+1-800-230-4134Check Rates
10015 South Main St., Houston, TX 77025
  • 4.0/5, Very Good Recent Reviews
  • Low priced Downtown hotel
  • 53 rooms in hotel
~4.76 Miles from 77221
Motel 6 Houston Reliant Park #1126
+1-800-997-5148Check Rates
3223 South Loop West, Houston, TX 77025
  • Cheap hotel
  • Check in: 3:00 PM
~4.77 Miles from 77221



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