Hotels in 77221

Hotels in 77221 - Houston TX

Only hotels in 77221 zip code are listed below. Search for cheap and discount hotel rates in Houston, TX for your upcoming leisure or conference / group travel. We list the best 77221 hotels and motels so you can review the Houston hotel list below to find the perfect lodging. Hotels in Harris county and area code 713 are also listed.


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77221 Hotels/Accommodations

Photo of Extended Stay America Houston Greenway Plaza Extended Stay America Houston Greenway Plaza
+1-800-230-4134Check Rates
2330 SW Frwy, Houston, TX 77098
  • 3.5/5, Average Recent Reviews
  • Economical Downtown property
  • 3 floors in hotel
~1.17 Miles from 77221
Photo of Hilton University of Houston Hilton University of Houston
+1-800-997-5148Check Rates
4800 Calhoun Rd., Houston, TX 77004
  • 4.0/5, Very Good Hotel Reviews
  • High-end Downtown hotel
  • Hotel has 10 meeting rooms
~1.41 Miles from 77221
Exterior of Mainstay Suites Mainstay Suites : 3134 Old Spanish Trail
+1-800-997-5149Check Rates
3134 Old Spanish Trail, Houston, TX 77054
  • 4.0/5, Very Good Guest Reviews
  • Cheap Convention Center property
  • Fitness + Health Center
~1.49 Miles from 77221
Extended Stay Deluxe Houston Medical Center in Houston
+1-800-230-4134Check Rates
1301 Braeswood Blvd., Houston, TX 77030
  • 3.0/5, Average Latest Reviews
  • Three Star Convention Center property
  • Check-in: 3:00pm
~2.52 Miles from 77221
Exterior of Hotel Zaza Houston Hotel Zaza Houston - Houston
+1-800-997-5148Check Rates
5701 Main St., Houston, TX 77005
  • 4.5/5, Very Good Hotel Reviews
  • 4-star Downtown hotel
  • Hotel has 75 suites
~2.57 Miles from 77221
Photo of Lexington Hotel Houston Medical Center Lexington Hotel Houston Medical Center
+1-800-997-5149Check Rates
1025 Swanson St., Houston, TX 77030
  • 4.0/5, Very Good Read Reviews
  • Affordable Downtown hotel
  • 38 sleeping rooms in hotel
~2.74 Miles from 77221
Image of Houston Marriott Medical Center Hotel Houston Marriott Medical Center Hotel
+1-800-230-4134Check Rates
6580 Fannin, Houston, TX 77030
  • 4.0/5, Very Good Latest Reviews
  • High end Downtown hotel
  • Hotel has 26 floors
~2.77 Miles from 77221
Image of Hotel Icon Hotel Icon - Houston
+1-800-997-5148Check Rates
200 Main St., Houston, TX 77002
  • Four star Downtown hotel
  • 12 floors in hotel
~2.79 Miles from 77221
Houston Marriott at the Texas Medical Center
+1-800-997-5149Check Rates
6580 Fannin Steet, Houston, TX 77030 ~2.80 Miles from 77221
Hampton Inn & Suites Houston Medical Center in Houston
+1-800-230-4134Check Rates
1715 Old Spanish Trail, Houston, TX 77054
  • 4.5/5, Very Good Recent Reviews
  • Midscale Convention Center property
  • Gym is available on property
~2.92 Miles from 77221
Best Western Plaza Hotel & Suites Medical Center
+1-800-997-5148Check Rates
6700 South Main St., Houston, TX 77030
  • 3.5/5, Average Review Score
  • Affordable Downtown hotel
  • 25 suites in property
~2.92 Miles from 77221
Hilton Houston Plaza / Medical Center - Houston
+1-800-997-5149Check Rates
6633 Travis, Houston, TX 77030
  • 4.0/5, Very Good Latest Reviews
  • 4 star Downtown property
  • 184 rooms in property
~2.93 Miles from 77221
Robin's Nest Bed & Breakfast Inn - Houston
+1-800-230-4134Check Rates
4104 Greeley St., Houston, TX 77006
  • 4.5/5, Very Good Latest Reviews
  • 2-star Downtown property
  • 2 meeting rooms in hotel
~2.99 Miles from 77221
Wyndham Hotel & Suites Houston Medical Center
+1-800-997-5148Check Rates
6800 Main St., Houston, TX 77030
  • 4.0/5, Very Good Reviews
  • Midscale Downtown hotel
  • Hotel has an eco-friendly policy Learn more
~2.99 Miles from 77221
Homestead Studio Suites - Houston
+1-800-997-5149Check Rates
7979 Fannin, Houston, TX 77054
  • Low priced Downtown hotel
  • 3 floors in hotel
~3.02 Miles from 77221
Holiday Inn Express & Suites Downtown - Houston
+1-800-230-4134Check Rates
1810 Bell St., Houston, TX 77003
  • 4.0/5, Very Good Reviews
  • Affordable Downtown hotel
  • 22 suites in property
~3.14 Miles from 77221
Hilton Americas Houston - Houston
+1-800-997-5148Check Rates
1600 Lamar, Houston, TX 77010
  • 4.5/5, Very Good Read Reviews
  • 4 star Downtown property
  • Gym is available on property
~3.32 Miles from 77221
Springhill Suites Houston Medical Center / Reliant
+1-800-997-5149Check Rates
1400 Old Spanish Trail, Houston, TX 77054
  • 4.0/5, Very Good Recent Reviews
  • 3-star Downtown property
  • Free breakfast available
~3.33 Miles from 77221
Athens Hotel - Houston
+1-800-230-4134Check Rates
1308 Clay St., Houston, TX 77002
  • 3.5/5, Average Recent Reviews
  • Low-priced Downtown property
  • Free breakfast available
~3.41 Miles from 77221
Courtyard by Marriott Houston Medical Center : Houston Medical Center 7702 Main St.
+1-800-997-5148Check Rates
Houston Medical Center 7702 Main St., Houston, TX 77030
  • 4.0/5, Very Good Hotel Reviews
  • Mid-scale Suburban hotel
  • 8 suites in hotel
~3.48 Miles from 77221
Holiday Inn Houston Reliant Park Area - Houston
+1-800-997-5149Check Rates
8111 Kirby Dr., Houston, TX 77054
  • 3.5/5, Average Guest Reviews
  • Midscale Suburban property
  • Hotel has 3 meeting rooms
~3.51 Miles from 77221
Extended Stay America Houston Reliant Pk. La Conch : 1303 La Concha Ln
+1-800-230-4134Check Rates
1303 La Concha Ln, Houston, TX 77054
  • 3.0/5, Average Hotel Reviews
  • Midscale Convention Center property
  • 45 suites in property
~3.52 Miles from 77221
Four Seasons Hotel Houston in Houston
+1-800-997-5148Check Rates
1300 Lamar St., Houston, TX 77010
  • 4.5/5, Very Good Guest Reviews
  • Luxurious 5-star Downtown hotel
  • 404 sleeping rooms in hotel
~3.52 Miles from 77221
Moody Manor at the Houston Medical Center
+1-800-997-5149Check Rates
7706 South Main, Houston, TX 77030
  • Low priced Downtown property
  • 14 suites in property
~3.53 Miles from 77221
Residence Inn by Marriott Medical Center / Reliant
+1-800-230-4134Check Rates
7710 Main St., Houston, TX 77030
  • 3.5/5, Average Recent Reviews
  • Three Star Highway hotel
  • Free comp. breakfast
~3.60 Miles from 77221
Residence Inn by Marriott : 7710 Main St.
+1-800-997-5148Check Rates
7710 Main St., Houston, TX 77030
  • Three Star Highway hotel
  • Shuttle from airport available
~3.60 Miles from 77221
Rodeway Inn & Suites
+1-800-997-5149Check Rates
6712 Morningside Dr., Houston, TX 77030
  • 1.5/5, Terrible Read Reviews
  • Low-priced Downtown hotel
  • 31 suites in hotel
~3.61 Miles from 77221
Image of Crowne Plaza Houston Downtown Crowne Plaza Houston Downtown in Houston
+1-800-230-4134Check Rates
1700 Smith St., Houston, TX 77002
  • 4.0/5, Very Good Hotel Reviews
  • Expensive Downtown property
  • 259 sleeping rooms in hotel
~3.62 Miles from 77221
Residence Inn Houston Downtown
+1-800-997-5148Check Rates
904 Dallas St., Houston, TX 77002
  • 4.0/5, Very Good Read Reviews
  • Midscale Downtown hotel
  • 171 rooms in hotel
~3.64 Miles from 77221
Courtyard Houston Downtown in Houston
+1-800-997-5149Check Rates
916 Dallas St., Houston, TX 77002
  • 3.5/5, Average Read Reviews
  • 3-star Downtown hotel
  • Hotel has 9 floors
~3.64 Miles from 77221
Parkview Inn & Suites
+1-800-230-4134Check Rates
9000 South Main, Houston, TX 77025
  • 2 star hotel
~3.68 Miles from 77221
The Westin Houston Downtown : 1520 Texas Ave.
+1-800-997-5148Check Rates
1520 Texas Ave., Houston, TX 77002
  • 4.0/5, Very Good Latest Reviews
  • Four-star Downtown hotel
  • 200 sleeping rooms in hotel
~3.71 Miles from 77221
Holiday Inn Express Suites Medical Center in Houston
+1-800-997-5149Check Rates
8080 South Main St., Houston, TX 77025
  • 4.0/5, Very Good Reviews
  • 3-star Downtown hotel
  • Comp. Breakfast
~3.72 Miles from 77221
Hyatt Regency Houston - Houston
+1-800-230-4134Check Rates
1200 Louisiana St., Houston, TX 77002
  • 4.0/5, Very Good Latest Reviews
  • 4-star Downtown property
  • 947 rooms in property
~3.78 Miles from 77221
Comfort Suites in Houston
+1-800-997-5148Check Rates
1055 Mcnee Rd., Houston, TX 77054
  • 3.5/5, Average Guest Reviews
  • Low-priced Convention Center hotel
  • Gym / Fitness Center Available
~3.82 Miles from 77221
Magnolia Hotel in Houston
+1-800-997-5149Check Rates
1100 Texas Ave., Houston, TX 77002
  • 4.5/5, Very Good Reviews
  • Four-star Downtown hotel
  • Fitness / Gym is on-site
~3.84 Miles from 77221
Crowne Plaza Houston Near Reliant Medical
+1-800-230-4134Check Rates
8686 Kirby Dr., Houston, TX 77054
  • 3.0/5, Average Guest Reviews
  • Midscale Convention Center property
  • Check-in: 12pm
~3.86 Miles from 77221
Doubletree Houston Downtown : 400 Dallas St.
+1-800-997-5148Check Rates
400 Dallas St., Houston, TX 77002
  • 4.0/5, Very Good Reviews
  • Mid-scale Downtown property
  • Check in: 3:00pm
~3.89 Miles from 77221
The Sam Houston Hotel in Houston
+1-800-997-5149Check Rates
1117 Prairie St., Houston, TX 77002
  • 4.0/5, Very Good Review Score
  • 4-star Downtown hotel
  • 3 meeting rooms in property
~3.91 Miles from 77221
Best Western Downtown Inn & Suites : 915 West Dallas
+1-800-230-4134Check Rates
915 West Dallas, Houston, TX 77019
  • 4.5/5, Very Good Reviews
  • Midscale Downtown property
  • Check-in: 2:00PM
~3.97 Miles from 77221
The Quality Inn & Suites Reliant Park : 2364 South Loop West
+1-800-997-5148Check Rates
2364 South Loop West, Houston, TX 77054
  • 3.5/5, Average Recent Reviews
  • Mid-scale Convention Center hotel
  • Hotel has 21 suites
~3.99 Miles from 77221
The Lancaster Hotel Houston : 701 Texas Ave.
+1-800-997-5149Check Rates
701 Texas Ave., Houston, TX 77002
  • Expensive Downtown property
  • 93 rooms in hotel
~4.04 Miles from 77221
Crowne Plaza Houston River Oaks in Houston
+1-800-230-4134Check Rates
2712 Southwest Fwy, Houston, TX 77098
  • 4.5/5, Very Good Review Score
  • 4-star Downtown hotel
  • Hotel has 18 floors
~4.38 Miles from 77221
Four Points by Sheraton Houston Southwest : 2828 Southwest Fwy
+1-800-997-5148Check Rates
2828 Southwest Fwy, Houston, TX 77098
  • 3.0/5, Average Review Score
  • 3-star Downtown hotel
  • Access to gym on-site
~4.48 Miles from 77221
Residence Inn
+1-800-997-5149Check Rates
2939 Westpark Dr., Houston, TX 77005
  • 4.0/5, Very Good Hotel Reviews
  • Mid-scale Downtown hotel
  • 120 rooms in property
~4.48 Miles from 77221
Courtyard by Marriott Houston West University
+1-800-230-4134Check Rates
2929 Westpark Dr., Houston, TX 77005
  • 4.0/5, Very Good Review Score
  • Midscale Suburban hotel
  • Hotel has 100 rooms
~4.49 Miles from 77221
Greenway Inn & Suites : 2929 Southwest Freeway
+1-800-997-5148Check Rates
2929 Southwest Freeway, Houston, TX 77098
  • 1.5/5, Terrible Recent Reviews
  • Low-priced Suburban hotel
  • 160 rooms in property
~4.50 Miles from 77221
La Quinta Inn Reliant / Medical Center - Houston
+1-800-997-5149Check Rates
9911 Buffalo Speedway, Houston, TX 77054
  • 3.5/5, Average Read Reviews
  • Cheap Downtown hotel
  • 113 sleeping rooms in hotel
~4.54 Miles from 77221
Americas Best Value Inn : 9604 South Main
+1-800-230-4134Check Rates
9604 South Main, Houston, TX 77025
  • 3.5/5, Average Read Reviews
  • Economy Convention Center hotel
  • 2 floors in hotel
~4.68 Miles from 77221
Executive Inn & Suites - Houston
+1-800-997-5148Check Rates
6711 Telephone Rd., Houston, TX 77061 ~4.75 Miles from 77221



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