Hotels in 77221 - Houston TX

Only hotels in 77221 zip code are listed below. Search for cheap and discount hotel rates in Houston, TX for your upcoming leisure or conference / group travel. We list the best 77221 hotels and motels so you can review the Houston hotel list below to find the perfect lodging. Hotels in Harris county and area code 713 are also listed.


Find availability nearby Rooms Check-In Check-Out  
Show Calendar Show Calendar Start My Search >
(select the discounts you qualify for)
Star Rating




Hotel Name

Price Range (USD)
to
Amenities







Set My Filter

77221 Hotels/Accommodations

Image of Extended Stay America Houston Greenway Plaza Extended Stay America Houston Greenway Plaza
+1-800-230-4134Check Rates
2330 SW Frwy, Houston, TX 77098
  • 3.5/5, Average Guest Reviews
  • Cheap Downtown property
  • 3 floors in hotel
~1.17 Miles from 77221
Photo of Hilton University of Houston Hilton University of Houston : 4800 Calhoun Rd.
+1-800-997-5148Check Rates
4800 Calhoun Rd., Houston, TX 77004
  • 4.0/5, Very Good Review Score
  • 4-star Downtown property
  • Fitness / Gym is on-site
~1.41 Miles from 77221
Photo of Mainstay Suites Mainstay Suites in Houston
+1-800-997-5149Check Rates
3134 Old Spanish Trail, Houston, TX 77054
  • 4.0/5, Very Good Recent Reviews
  • 2-star Convention Center hotel
  • Free breakfast
~1.49 Miles from 77221
Extended Stay Deluxe Houston Medical Center - Houston
+1-800-230-4134Check Rates
1301 Braeswood Blvd., Houston, TX 77030
  • 3.0/5, Average Recent Reviews
  • Midscale Convention Center hotel
  • Access to gym on-site
~2.52 Miles from 77221
Exterior of Hotel Zaza Houston Hotel Zaza Houston
+1-800-997-5148Check Rates
5701 Main St., Houston, TX 77005
  • 4.5/5, Very Good Read Reviews
  • Four star Downtown property
  • Check in time: 4:00 PM
~2.57 Miles from 77221
Image of Lexington Hotel Houston Medical Center Lexington Hotel Houston Medical Center : 1025 Swanson St.
+1-800-997-5149Check Rates
1025 Swanson St., Houston, TX 77030
  • 4.0/5, Very Good Review Score
  • 3 star Downtown property
  • Free comp. breakfast
~2.74 Miles from 77221
Exterior of Houston Marriott Medical Center Hotel Houston Marriott Medical Center Hotel in Houston
+1-800-230-4134Check Rates
6580 Fannin, Houston, TX 77030
  • 4.0/5, Very Good Review Score
  • Expensive Downtown hotel
  • Check in time: 4PM
~2.77 Miles from 77221
Image of Hotel Icon Hotel Icon in Houston
+1-800-997-5148Check Rates
220 Main St., Houston, TX 77002
  • 4 star Downtown hotel
  • 15 suites in hotel
~2.79 Miles from 77221
Houston Marriott at the Texas Medical Center in Houston
+1-800-997-5149Check Rates
6580 Fannin Steet, Houston, TX 77030 ~2.80 Miles from 77221
Hampton Inn & Suites Houston Medical Center : 1715 Old Spanish Trail
+1-800-230-4134Check Rates
1715 Old Spanish Trail, Houston, TX 77054
  • 4.5/5, Very Good Hotel Reviews
  • Affordable Convention Center hotel
  • 5 floors in hotel
~2.92 Miles from 77221
Hilton Houston Plaza Medical Center
+1-800-997-5148Check Rates
6633 Travis, Houston, TX 77030
  • 4.0/5, Very Good Read Reviews
  • Midscale Downtown property
  • 185 sleeping rooms in hotel
~2.93 Miles from 77221
Robin's Nest Bed & Breakfast Inn : 4104 Greeley St.
+1-800-997-5149Check Rates
4104 Greeley St., Houston, TX 77006
  • 4.5/5, Very Good Review Score
  • 2 star Downtown property
  • 3 suites in property
~2.99 Miles from 77221
Wyndham Houston Medical Center Hotel & Suite : 6800 Main St.
+1-800-230-4134Check Rates
6800 Main St., Houston, TX 77030 ~2.99 Miles from 77221
Homestead Studio Suites : 7979 Fannin
+1-800-997-5148Check Rates
7979 Fannin, Houston, TX 77054
  • Low priced Downtown property
  • 3 floors in hotel
~3.02 Miles from 77221
Holiday Inn Express & Suites Downtown - Houston
+1-800-997-5149Check Rates
1810 Bell St., Houston, TX 77003
  • 4.0/5, Very Good Review Score
  • 3-star Downtown hotel
  • Check in: 3:00pm
~3.14 Miles from 77221
Hilton Americas Houston : 1600 Lamar
+1-800-230-4134Check Rates
1600 Lamar, Houston, TX 77010
  • 4.5/5, Very Good Read Reviews
  • 4-star Downtown hotel
  • 27 meeting rooms in property
~3.32 Miles from 77221
Springhill Suites Houston Medical Center / Reliant : 1400 Old Spanish Trail
+1-800-997-5148Check Rates
1400 Old Spanish Trail, Houston, TX 77054
  • 4.0/5, Very Good Guest Reviews
  • Three Star Downtown hotel
  • Fitness center on property
~3.33 Miles from 77221
Athens Hotel
+1-800-997-5149Check Rates
1308 Clay St., Houston, TX 77002
  • 3.5/5, Average Hotel Reviews
  • Low-priced Downtown property
  • Check-in: 2PM
~3.41 Miles from 77221
Courtyard by Marriott Houston Medical Center
+1-800-230-4134Check Rates
Houston Medical Center 7702 Main St., Houston, TX 77030
  • 4.0/5, Very Good Reviews
  • 3 star Suburban property
  • 197 rooms in property
~3.48 Miles from 77221
Holiday Inn Houston Reliant Park Area
+1-800-997-5148Check Rates
8111 Kirby Dr., Houston, TX 77054
  • 3.5/5, Average Guest Reviews
  • Mid-scale Suburban hotel
  • Hotel has 11 floors
~3.51 Miles from 77221
Extended Stay America Houston Reliant Pk. La Conch : 1303 La Concha Ln
+1-800-997-5149Check Rates
1303 La Concha Ln, Houston, TX 77054
  • 3.0/5, Average Review Score
  • 3-star Convention Center hotel
  • Hotel has 84 rooms
~3.52 Miles from 77221
Four Seasons Hotel Houston
+1-800-230-4134Check Rates
1300 Lamar St., Houston, TX 77010
  • 4.5/5, Very Good Latest Reviews
  • Luxurious Five Star Downtown property
  • Fitness center on property
~3.52 Miles from 77221
Moody Manor at the Houston Medical Center - Houston
+1-800-997-5148Check Rates
7706 South Main, Houston, TX 77030
  • 2 star Downtown hotel
  • 14 suites in hotel
~3.53 Miles from 77221
Residence Inn by Marriott Medical Center / Reliant in Houston
+1-800-997-5149Check Rates
7710 Main St., Houston, TX 77030
  • 3.5/5, Average Hotel Reviews
  • Three Star Highway property
  • Hotel has 2 floors
~3.60 Miles from 77221
Crowne Plaza Houston Downtown : 1700 Smith St.
+1-800-230-4134Check Rates
1700 Smith St., Houston, TX 77002
  • 4 star Downtown hotel
  • Shuttle from airport available
~3.62 Miles from 77221
Rodeway Inn Suites in Houston
+1-800-997-5148Check Rates
6712 Morningside Dr., Houston, TX 77030
  • Economical Downtown hotel
  • Free breakfast
~3.63 Miles from 77221
Residence Inn Houston Downtown : 904 Dallas St.
+1-800-997-5149Check Rates
904 Dallas St., Houston, TX 77002
  • 4.0/5, Very Good Read Reviews
  • Three Star Downtown property
  • Check in: 300PM
~3.64 Miles from 77221
Courtyard Houston Downtown in Houston
+1-800-230-4134Check Rates
916 Dallas St., Houston, TX 77002
  • 3.5/5, Average Reviews
  • Mid-scale Downtown property
  • 9 floors in property
~3.64 Miles from 77221
Parkview Inn & Suites
+1-800-997-5148Check Rates
9000 South Main, Houston, TX 77025
  • Inexpensive property
~3.68 Miles from 77221
The Westin Houston Downtown - Houston
+1-800-997-5149Check Rates
1520 Texas Ave., Houston, TX 77002
  • 4.5/5, Very Good Hotel Reviews
  • 4-star Downtown property
  • 20 suites in property
~3.71 Miles from 77221
Holiday Inn Express Suites Medical Center in Houston
+1-800-230-4134Check Rates
8080 South Main St., Houston, TX 77025
  • 4.0/5, Very Good Latest Reviews
  • 3 star Downtown hotel
  • Fitness / Gym is on-site
~3.72 Miles from 77221
Hyatt Regency Houston - Houston
+1-800-997-5148Check Rates
1200 Louisiana St., Houston, TX 77002
  • 4.0/5, Very Good Latest Reviews
  • 4 star Downtown property
  • 30 floors in hotel
~3.78 Miles from 77221
Comfort Suites - Houston
+1-800-997-5149Check Rates
1055 Mcnee Rd., Houston, TX 77054
  • 3.5/5, Average Recent Reviews
  • 2-star Convention Center hotel
  • 50 suites in property
~3.82 Miles from 77221
JW Marriott Houston Downtown in Houston
+1-800-230-4134Check Rates
806 Main, Houston, TX 77002
  • 4-star property
~3.82 Miles from 77221
Magnolia Hotel : 1100 Texas Ave.
+1-800-997-5148Check Rates
1100 Texas Ave., Houston, TX 77002
  • 4.5/5, Very Good Guest Reviews
  • Expensive Downtown property
  • 23 floors in property
~3.84 Miles from 77221
Crowne Plaza Houston Near Reliant Medical - Houston
+1-800-997-5149Check Rates
8686 Kirby Dr., Houston, TX 77054
  • 3.0/5, Average Read Reviews
  • 3 star Convention Center property
  • Fitness + Health Center
~3.86 Miles from 77221
Doubletree Houston Downtown
+1-800-230-4134Check Rates
400 Dallas St., Houston, TX 77002
  • 4.0/5, Very Good Read Reviews
  • Affordable Downtown hotel
  • Check-in time: 3:00pm
~3.89 Miles from 77221
The Sam Houston Hotel
+1-800-997-5148Check Rates
1117 Prairie St., Houston, TX 77002
  • 4.0/5, Very Good Read Reviews
  • Mid-scale Downtown hotel
  • 10 floors in hotel
~3.91 Miles from 77221
Best Western Downtown Inn & Suites in Houston
+1-800-997-5149Check Rates
915 West Dallas, Houston, TX 77019
  • 4.5/5, Very Good Read Reviews
  • Mid-scale Downtown hotel
  • Check in time: 2:00PM
~3.97 Miles from 77221
The Quality Inn & Suites Reliant Park in Houston
+1-800-230-4134Check Rates
2364 South Loop West, Houston, TX 77054
  • 3.5/5, Average Recent Reviews
  • 3 star Convention Center property
  • Fitness + Health Center
~3.99 Miles from 77221
The Lancaster Hotel Houston in Houston
+1-800-997-5148Check Rates
701 Texas Ave., Houston, TX 77002
  • Four-star Downtown hotel
  • 9 suites in property
~4.04 Miles from 77221
Crowne Plaza Houston River Oaks : 2712 Southwest Fwy
+1-800-997-5149Check Rates
2712 Southwest Fwy, Houston, TX 77098
  • 4.5/5, Very Good Recent Reviews
  • Expensive Downtown property
  • Hotel has 355 rooms
~4.38 Miles from 77221
Four Points by Sheraton Houston Southwest
+1-800-230-4134Check Rates
2828 Southwest Fwy, Houston, TX 77098
  • 3.0/5, Average Review Score
  • Midscale Downtown property
  • 4 meeting rooms in hotel
~4.48 Miles from 77221
Residence Inn : 2939 Westpark Dr.
+1-800-997-5148Check Rates
2939 Westpark Dr., Houston, TX 77005
  • 4.0/5, Very Good Review Score
  • Mid-scale Downtown hotel
  • Hotel has 120 suites
~4.48 Miles from 77221
Courtyard by Marriott Houston West University : 2929 Westpark Dr.
+1-800-997-5149Check Rates
2929 Westpark Dr., Houston, TX 77005
  • 4.0/5, Very Good Hotel Reviews
  • Three Star Suburban property
  • 3 floors in property
~4.49 Miles from 77221
Greenway Inn & Suites : 2929 Southwest Freeway
+1-800-230-4134Check Rates
2929 Southwest Freeway, Houston, TX 77098
  • 1.5/5, Terrible Recent Reviews
  • Inexpensive Suburban hotel
  • 10 suites in hotel
~4.50 Miles from 77221
La Quinta Inn Reliant / Medical Center
+1-800-997-5148Check Rates
9911 Buffalo Speedway, Houston, TX 77054
  • 3.5/5, Average Reviews
  • 2-star Downtown hotel
  • 3 floors in property
~4.54 Miles from 77221
Americas Best Value Inn - Houston
+1-800-997-5149Check Rates
9604 South Main, Houston, TX 77025
  • 3.5/5, Average Hotel Reviews
  • Cheap Convention Center property
  • 2 floors in hotel
~4.68 Miles from 77221
Executive Inn & Suites
+1-800-230-4134Check Rates
6711 Telephone Rd., Houston, TX 77061 ~4.75 Miles from 77221
Carefree Inn at the Medical Center in Houston
+1-800-997-5148Check Rates
10015 South Main St., Houston, TX 77025
  • 4.0/5, Very Good Review Score
  • Low Cost Downtown hotel
  • 2 meeting rooms in hotel
~4.76 Miles from 77221



Next: Show All Available 77221 Hotels with Pricing >