Hotels in 77221 Houston (Texas)

Hotels in 77221 - Houston TX

Only hotels in 77221 zip code are listed below. Search for cheap and discount hotel rates in Houston, TX for your upcoming leisure or conference / group travel. We list the best 77221 hotels and motels so you can review the Houston hotel list below to find the perfect lodging. Hotels in Harris county and area code 713 are also listed.


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77221 Hotels & Accommodations

Photo of Extended Stay America Houston Greenway PlazaExtended Stay America Houston Greenway Plaza
+1-800-230-4134Check Rates
2330 SW Frwy, Houston, TX 77098
  • 3.5/5, Average Guest Reviews
  • Low Cost Downtown property
  • 122 sleeping rooms in hotel
~1.17 Miles from 77221
Photo of Hilton University of HoustonHilton University of Houston
+1-800-997-5148Check Rates
4800 Calhoun Rd., Houston, TX 77004
  • 4.0/5, Very Good Reviews
  • High end Downtown hotel
  • Fitness + Health Center
~1.41 Miles from 77221
Image of Mainstay SuitesMainstay Suites
+1-800-997-5149Check Rates
3134 Old Spanish Trail, Houston, TX 77054
  • 4.0/5, Very Good Recent Reviews
  • Low-priced Convention Center property
  • Fitness / Gym is on-site
~1.49 Miles from 77221
Extended Stay Deluxe Houston Medical Center
+1-800-230-4134Check Rates
1301 Braeswood Blvd., Houston, TX 77030
  • 3.0/5, Average Recent Reviews
  • 3 star Convention Center hotel
  • Free comp. breakfast
~2.52 Miles from 77221
Photo of Hotel Zaza HoustonHotel Zaza Houston
+1-800-997-5148Check Rates
5701 Main St., Houston, TX 77005
  • 4.5/5, Very Good Latest Reviews
  • Expensive Downtown property
  • Fitness / Gym is on-site
~2.57 Miles from 77221
Photo of Lexington Hotel Houston Medical CenterLexington Hotel Houston Medical Center - Houston
+1-800-997-5149Check Rates
1025 Swanson St., Houston, TX 77030
  • 4.0/5, Very Good Recent Reviews
  • Affordable Downtown hotel
  • 38 rooms in hotel
~2.74 Miles from 77221
Photo of Houston Marriott Medical Center HotelHouston Marriott Medical Center Hotel
+1-800-230-4134Check Rates
6580 Fannin, Houston, TX 77030
  • 4.0/5, Very Good Read Reviews
  • Four-star Downtown hotel
  • 386 sleeping rooms in hotel
~2.77 Miles from 77221
Photo of Hotel IconHotel Icon
+1-800-997-5148Check Rates
220 Main St., Houston, TX 77002
  • Expensive Downtown property
  • Check in: 03:00 PM
~2.79 Miles from 77221
Houston Marriott at the Texas Medical Center
+1-800-997-5149Check Rates
6580 Fannin Steet, Houston, TX 77030
  • 4.0/5, Very Good Reviews
  • High end property
~2.80 Miles from 77221
Hampton Inn & Suites Houston Medical Center - Houston
+1-800-230-4134Check Rates
1715 Old Spanish Trail, Houston, TX 77054
  • 4.5/5, Very Good Reviews
  • Affordable Convention Center hotel
  • 120 rooms in property
~2.92 Miles from 77221
Hilton Houston Plaza Medical Center : 6633 Travis
+1-800-997-5148Check Rates
6633 Travis, Houston, TX 77030
  • 4.0/5, Very Good Guest Reviews
  • Three Star Downtown property
  • Hotel has 185 rooms
~2.93 Miles from 77221
Robin's Nest Bed & Breakfast Inn : 4104 Greeley St.
+1-800-997-5149Check Rates
4104 Greeley St., Houston, TX 77006
  • 4.5/5, Very Good Guest Reviews
  • Inexpensive Downtown property
  • 3 suites in hotel
~2.99 Miles from 77221
Wyndham Houston Medical Center Hotel & Suite : 6800 Main St.
+1-800-230-4134Check Rates
6800 Main St., Houston, TX 77030
  • 4.0/5, Very Good Latest Reviews
  • Affordable Downtown property
  • 215 suites in property
~2.99 Miles from 77221
Homestead Studio Suites - Houston
+1-800-997-5148Check Rates
7979 Fannin, Houston, TX 77054
  • 2 star Downtown hotel
  • 12 suites in property
~3.02 Miles from 77221
Holiday Inn Express & Suites Downtown
+1-800-997-5149Check Rates
1810 Bell St., Houston, TX 77003
  • 4.0/5, Very Good Read Reviews
  • Midscale Downtown property
  • 112 rooms in hotel
~3.14 Miles from 77221
Hilton Americas Houston in Houston
+1-800-230-4134Check Rates
1600 Lamar, Houston, TX 77010~3.32 Miles from 77221
Springhill Suites Houston Medical Center / Reliant in Houston
+1-800-997-5148Check Rates
1400 Old Spanish Trail, Houston, TX 77054
  • 4.0/5, Very Good Latest Reviews
  • Three Star Downtown property
  • Check in time: 3:00PM
~3.33 Miles from 77221
Athens Hotel in Houston
+1-800-997-5149Check Rates
1308 Clay St., Houston, TX 77002
  • 3.5/5, Average Review Score
  • 2 star Downtown hotel
  • 2 floors in hotel
~3.41 Miles from 77221
Courtyard by Marriott Houston Medical Center : Houston Medical Center 7702 Main St.
+1-800-230-4134Check Rates
Houston Medical Center 7702 Main St., Houston, TX 77030
  • 4.0/5, Very Good Hotel Reviews
  • 3 star Suburban hotel
  • Check-in: 3:00 PM
~3.48 Miles from 77221
Holiday Inn Houston Reliant Park Area - Houston
+1-800-997-5148Check Rates
8111 Kirby Dr., Houston, TX 77054
  • 3.5/5, Average Latest Reviews
  • Three Star Suburban property
  • Hotel has 6 suites
~3.51 Miles from 77221
Extended Stay America Houston Reliant Pk. La Conch - Houston
+1-800-997-5149Check Rates
1303 La Concha Ln, Houston, TX 77054
  • 3.0/5, Average Latest Reviews
  • Mid-scale Convention Center property
  • 84 rooms in property
~3.52 Miles from 77221
Four Seasons Hotel Houston
+1-800-230-4134Check Rates
1300 Lamar St., Houston, TX 77010
  • 4.5/5, Very Good Reviews
  • Luxury 5 star Downtown hotel
  • 404 rooms in hotel
~3.52 Miles from 77221
Moody Manor at the Houston Medical Center : 7706 South Main
+1-800-997-5148Check Rates
7706 South Main, Houston, TX 77030
  • Low-priced Downtown property
  • Check-in time: 3:00pm
~3.53 Miles from 77221
Residence Inn by Marriott Medical Center / Reliant in Houston
+1-800-997-5149Check Rates
7710 Main St., Houston, TX 77030
  • 3.5/5, Average Hotel Reviews
  • Affordable Highway hotel
  • Check-in: 3:00pm
~3.60 Miles from 77221
Photo of Crowne Plaza Houston DowntownCrowne Plaza Houston Downtown - Houston
+1-800-230-4134Check Rates
1700 Smith St., Houston, TX 77002 Website
  • Expensive Downtown hotel
  • 259 rooms in hotel
~3.62 Miles from 77221
Rodeway Inn Suites
+1-800-997-5148Check Rates
6712 Morningside Dr., Houston, TX 77030
  • Two-star Downtown hotel
  • 33 rooms in property
~3.63 Miles from 77221
Residence Inn Houston Downtown
+1-800-997-5149Check Rates
904 Dallas St., Houston, TX 77002
  • 4.0/5, Very Good Reviews
  • Mid-scale Downtown property
  • Check in: 300PM
~3.64 Miles from 77221
Courtyard Houston Downtown
+1-800-230-4134Check Rates
916 Dallas St., Houston, TX 77002
  • 3.5/5, Average Read Reviews
  • 3-star Downtown hotel
  • 191 sleeping rooms in hotel
~3.64 Miles from 77221
Parkview Inn & Suites in Houston
+1-800-997-5148Check Rates
9000 South Main, Houston, TX 77025
  • Low-priced property
~3.68 Miles from 77221
The Westin Houston Downtown : 1520 Texas Ave.
+1-800-997-5149Check Rates
1520 Texas Ave., Houston, TX 77002
  • 4.5/5, Very Good Guest Reviews
  • High end Downtown property
  • Gym is available on property
~3.71 Miles from 77221
Holiday Inn Express Suites Medical Center : 8080 South Main St.
+1-800-230-4134Check Rates
8080 South Main St., Houston, TX 77025~3.72 Miles from 77221
Hyatt Regency Houston
+1-800-997-5148Check Rates
1200 Louisiana St., Houston, TX 77002
  • 4.0/5, Very Good Review Score
  • High end Downtown property
  • Hotel has 30 meeting rooms
~3.78 Miles from 77221
Comfort Suites
+1-800-997-5149Check Rates
1055 Mcnee Rd., Houston, TX 77054
  • 3.5/5, Average Guest Reviews
  • Cheap Convention Center hotel
  • 50 suites in hotel
~3.82 Miles from 77221
Magnolia Hotel : 1100 Texas Ave.
+1-800-230-4134Check Rates
1100 Texas Ave., Houston, TX 77002
  • 4.5/5, Very Good Guest Reviews
  • High end Downtown hotel
  • Check-in: 3:00 PM
~3.84 Miles from 77221
Crowne Plaza Houston Near Reliant Medical in Houston
+1-800-997-5148Check Rates
8686 Kirby Dr., Houston, TX 77054
  • 3.0/5, Average Recent Reviews
  • 3-star Convention Center property
  • Hotel has 8 floors
~3.86 Miles from 77221
Doubletree Houston Downtown : 400 Dallas St.
+1-800-997-5149Check Rates
400 Dallas St., Houston, TX 77002
  • 4.0/5, Very Good Recent Reviews
  • Midscale Downtown property
  • Access to gym on-site
~3.89 Miles from 77221
The Sam Houston Hotel in Houston
+1-800-230-4134Check Rates
1117 Prairie St., Houston, TX 77002
  • 4.0/5, Very Good Reviews
  • 3 star Downtown property
  • Fitness center on property
~3.91 Miles from 77221
Best Western Downtown Inn & Suites
+1-800-997-5148Check Rates
915 West Dallas, Houston, TX 77019
  • 4.5/5, Very Good Read Reviews
  • Mid-scale Downtown hotel
  • Access to gym on-site
~3.97 Miles from 77221
The Quality Inn & Suites Reliant Park in Houston
+1-800-997-5149Check Rates
2364 South Loop West, Houston, TX 77054
  • 3.5/5, Average Reviews
  • Affordable Convention Center property
  • 21 suites in property
~3.99 Miles from 77221
The Lancaster Hotel Houston in Houston
+1-800-230-4134Check Rates
701 Texas Ave., Houston, TX 77002
  • Expensive Downtown hotel
  • 12 floors in hotel
~4.04 Miles from 77221
Crowne Plaza Houston River Oaks in Houston
+1-800-997-5148Check Rates
2712 Southwest Fwy, Houston, TX 77098
  • 4.5/5, Very Good Guest Reviews
  • 4-star Downtown property
  • 36 suites in property
~4.38 Miles from 77221
Four Points by Sheraton Houston Southwest
+1-800-997-5149Check Rates
2828 Southwest Fwy, Houston, TX 77098
  • 3.0/5, Average Guest Reviews
  • Affordable Downtown property
  • 9 floors in property
~4.48 Miles from 77221
Residence Inn - Houston
+1-800-230-4134Check Rates
2939 Westpark Dr., Houston, TX 77005
  • 4.0/5, Very Good Review Score
  • Midscale Downtown property
  • Comp. Breakfast
~4.48 Miles from 77221
Courtyard by Marriott Houston West University
+1-800-997-5148Check Rates
2929 Westpark Dr., Houston, TX 77005
  • 4.0/5, Very Good Review Score
  • Three Star Suburban hotel
  • 2 suites in hotel
~4.49 Miles from 77221
Greenway Inn & Suites
+1-800-997-5149Check Rates
2929 Southwest Freeway, Houston, TX 77098
  • 1.5/5, Terrible Read Reviews
  • Low priced Suburban hotel
  • Check in time: 1:00 PM
~4.50 Miles from 77221
La Quinta Inn Reliant / Medical Center
+1-800-230-4134Check Rates
9911 Buffalo Speedway, Houston, TX 77054
  • 3.5/5, Average Reviews
  • Cheap Downtown property
  • Hotel has 113 rooms
~4.54 Miles from 77221
Americas Best Value Inn
+1-800-997-5148Check Rates
9604 South Main, Houston, TX 77025
  • 3.5/5, Average Latest Reviews
  • 2 star Convention Center property
  • 2 suites in property
~4.68 Miles from 77221
Executive Inn & Suites in Houston
+1-800-997-5149Check Rates
6711 Telephone Rd., Houston, TX 77061~4.75 Miles from 77221
Carefree Inn at the Medical Center in Houston
+1-800-230-4134Check Rates
10015 South Main St., Houston, TX 77025
  • 4.0/5, Very Good Guest Reviews
  • Two star Downtown property
  • Shuttle to airport available
~4.76 Miles from 77221
Motel 6 Houston Reliant Park #1126 in Houston
+1-800-997-5148Check Rates
3223 South Loop West, Houston, TX 77025
  • 2-star property
  • Hotel has 111 rooms
~4.77 Miles from 77221



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