Hotels in 77221 - Houston TX

Only hotels in 77221 zip code are listed below. Search for cheap and discount hotel rates in Houston, TX for your upcoming leisure or conference / group travel. We list the best 77221 hotels and motels so you can review the Houston hotel list below to find the perfect lodging. Hotels in Harris county and area code 713 are also listed.


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77221 Hotels & Accommodations

Exterior of Extended Stay America Houston Greenway PlazaExtended Stay America Houston Greenway Plaza in Houston
+1-800-230-4134Check Rates
2330 SW Frwy, Houston, TX 77098
  • 3.5/5, Average Read Reviews
  • 2-star Downtown hotel
  • 2 suites in property
~1.17 Miles from 77221
Exterior of Hilton University of HoustonHilton University of Houston
+1-800-997-5148Check Rates
4800 Calhoun Rd., Houston, TX 77004
  • 4.0/5, Very Good Latest Reviews
  • High end Downtown property
  • 8 floors in hotel
~1.41 Miles from 77221
Photo of Mainstay SuitesMainstay Suites : 3134 Old Spanish Trail
+1-800-997-5149Check Rates
3134 Old Spanish Trail, Houston, TX 77054
  • 4.0/5, Very Good Read Reviews
  • Cheap Convention Center hotel
  • Airport shuttle provided
~1.49 Miles from 77221
Extended Stay Deluxe Houston Medical Center - Houston
+1-800-230-4134Check Rates
1301 Braeswood Blvd., Houston, TX 77030
  • 3.0/5, Average Hotel Reviews
  • Three Star Convention Center property
  • Gym / Fitness Center Available
~2.52 Miles from 77221
Exterior of Hotel Zaza HoustonHotel Zaza Houston
+1-800-997-5148Check Rates
5701 Main St., Houston, TX 77005
  • 4.5/5, Very Good Recent Reviews
  • Four-star Downtown hotel
  • Check-in: 4:00 PM
~2.57 Miles from 77221
Exterior of Lexington Hotel Houston Medical CenterLexington Hotel Houston Medical Center
+1-800-997-5149Check Rates
1025 Swanson St., Houston, TX 77030
  • 4.0/5, Very Good Latest Reviews
  • Midscale Downtown hotel
  • Free comp. breakfast
~2.74 Miles from 77221
Image of Houston Marriott Medical Center HotelHouston Marriott Medical Center Hotel in Houston
+1-800-230-4134Check Rates
6580 Fannin, Houston, TX 77030
  • 4.0/5, Very Good Hotel Reviews
  • High-end Downtown hotel
  • 386 rooms in hotel
~2.77 Miles from 77221
Image of Hotel IconHotel Icon : 220 Main St.
+1-800-997-5148Check Rates
220 Main St., Houston, TX 77002
  • Expensive Downtown property
  • Check in time: 03:00 PM
~2.79 Miles from 77221
Houston Marriott at the Texas Medical Center
+1-800-997-5149Check Rates
6580 Fannin Steet, Houston, TX 77030~2.80 Miles from 77221
Hampton Inn & Suites Houston Medical Center
+1-800-230-4134Check Rates
1715 Old Spanish Trail, Houston, TX 77054
  • 4.5/5, Very Good Hotel Reviews
  • Affordable Convention Center hotel
  • Free breakfast
~2.92 Miles from 77221
Hilton Houston Plaza Medical Center in Houston
+1-800-997-5148Check Rates
6633 Travis, Houston, TX 77030
  • 4.0/5, Very Good Review Score
  • Three Star Downtown property
  • Check in time: 03:00 PM
~2.93 Miles from 77221
Robin's Nest Bed & Breakfast Inn in Houston
+1-800-997-5149Check Rates
4104 Greeley St., Houston, TX 77006
  • 4.5/5, Very Good Review Score
  • Cheap Downtown hotel
  • 3 suites in hotel
~2.99 Miles from 77221
Wyndham Houston Medical Center Hotel & Suite in Houston
+1-800-230-4134Check Rates
6800 Main St., Houston, TX 77030
  • 4.0/5, Very Good Reviews
  • Midscale Downtown hotel
  • Airport shuttle available
~2.99 Miles from 77221
Homestead Studio Suites : 7979 Fannin
+1-800-997-5148Check Rates
7979 Fannin, Houston, TX 77054
  • 2 star Downtown property
  • 153 rooms in property
~3.02 Miles from 77221
Holiday Inn Express & Suites Downtown
+1-800-997-5149Check Rates
1810 Bell St., Houston, TX 77003
  • 4.0/5, Very Good Reviews
  • Midscale Downtown hotel
  • Free complimentary breakfast
~3.14 Miles from 77221
Hilton Americas Houston in Houston
+1-800-230-4134Check Rates
1600 Lamar, Houston, TX 77010~3.32 Miles from 77221
Springhill Suites Houston Medical Center / Reliant in Houston
+1-800-997-5148Check Rates
1400 Old Spanish Trail, Houston, TX 77054
  • 4.0/5, Very Good Review Score
  • Affordable Downtown hotel
  • Free comp. breakfast
~3.33 Miles from 77221
Athens Hotel in Houston
+1-800-997-5149Check Rates
1308 Clay St., Houston, TX 77002
  • 3.5/5, Average Hotel Reviews
  • Two-star Downtown property
  • Gym / Fitness Center Available
~3.41 Miles from 77221
Courtyard by Marriott Houston Medical Center
+1-800-230-4134Check Rates
Houston Medical Center 7702 Main St., Houston, TX 77030
  • 4.0/5, Very Good Recent Reviews
  • Affordable Suburban property
  • Fitness / Gym is on-site
~3.48 Miles from 77221
Holiday Inn Houston Reliant Park Area - Houston
+1-800-997-5148Check Rates
8111 Kirby Dr., Houston, TX 77054
  • 3.5/5, Average Read Reviews
  • Midscale Suburban hotel
  • Gym is available on property
~3.51 Miles from 77221
Extended Stay America Houston Reliant Pk. La Conch
+1-800-997-5149Check Rates
1303 La Concha Ln, Houston, TX 77054
  • 3.0/5, Average Recent Reviews
  • Three Star Convention Center hotel
  • Check in: 3pm
~3.52 Miles from 77221
Four Seasons Hotel Houston
+1-800-230-4134Check Rates
1300 Lamar St., Houston, TX 77010
  • 4.5/5, Very Good Reviews
  • Luxurious 5 Star Downtown hotel
  • Hotel has 14 meeting rooms
~3.52 Miles from 77221
Moody Manor at the Houston Medical Center
+1-800-997-5148Check Rates
7706 South Main, Houston, TX 77030
  • Two-star Downtown property
  • Hotel has 14 suites
~3.53 Miles from 77221
Residence Inn by Marriott Medical Center / Reliant
+1-800-997-5149Check Rates
7710 Main St., Houston, TX 77030
  • 3.5/5, Average Guest Reviews
  • Mid-scale Highway property
  • Shuttle from airport available
~3.60 Miles from 77221
Crowne Plaza Houston Downtown
+1-800-230-4134Check Rates
1700 Smith St., Houston, TX 77002
  • Four star Downtown hotel
  • 12 floors in property
~3.62 Miles from 77221
Rodeway Inn Suites : 6712 Morningside Dr.
+1-800-997-5148Check Rates
6712 Morningside Dr., Houston, TX 77030
  • Low-priced Downtown property
  • Hotel has 31 suites
~3.63 Miles from 77221
Residence Inn Houston Downtown
+1-800-997-5149Check Rates
904 Dallas St., Houston, TX 77002
  • 4.0/5, Very Good Hotel Reviews
  • Midscale Downtown property
  • Complimentary breakfast is offered
~3.64 Miles from 77221
Courtyard Houston Downtown
+1-800-230-4134Check Rates
916 Dallas St., Houston, TX 77002
  • 3.5/5, Average Hotel Reviews
  • Three Star Downtown property
  • 191 sleeping rooms in hotel
~3.64 Miles from 77221
Parkview Inn & Suites : 9000 South Main
+1-800-997-5148Check Rates
9000 South Main, Houston, TX 77025
  • Low-priced property
~3.68 Miles from 77221
The Westin Houston Downtown - Houston
+1-800-997-5149Check Rates
1520 Texas Ave., Houston, TX 77002~3.71 Miles from 77221
Holiday Inn Express Suites Medical Center in Houston
+1-800-230-4134Check Rates
8080 South Main St., Houston, TX 77025
  • 4.0/5, Very Good Latest Reviews
  • Mid-scale Downtown property
  • Free comp. breakfast
~3.72 Miles from 77221
Hyatt Regency Houston : 1200 Louisiana St.
+1-800-997-5148Check Rates
1200 Louisiana St., Houston, TX 77002
  • 4.0/5, Very Good Latest Reviews
  • 4-star Downtown property
  • 30 floors in hotel
~3.78 Miles from 77221
Comfort Suites - Houston
+1-800-997-5149Check Rates
1055 Mcnee Rd., Houston, TX 77054
  • 3.5/5, Average Review Score
  • Two-star Convention Center hotel
  • Hotel has 4 floors
~3.82 Miles from 77221
JW Marriott Houston Downtown in Houston
+1-800-230-4134Check Rates
806 Main, Houston, TX 77002
  • Luxury 5 star property
~3.82 Miles from 77221
Magnolia Hotel - Houston
+1-800-997-5148Check Rates
1100 Texas Ave., Houston, TX 77002
  • 4.5/5, Very Good Reviews
  • High end Downtown property
  • 314 rooms in property
~3.84 Miles from 77221
Crowne Plaza Houston Near Reliant Medical : 8686 Kirby Dr.
+1-800-997-5149Check Rates
8686 Kirby Dr., Houston, TX 77054
  • 3.0/5, Average Guest Reviews
  • Mid-scale Convention Center property
  • Gym is available on property
~3.86 Miles from 77221
Doubletree Houston Downtown : 400 Dallas St.
+1-800-230-4134Check Rates
400 Dallas St., Houston, TX 77002
  • 4.0/5, Very Good Review Score
  • Three Star Downtown hotel
  • Fitness center on property
~3.89 Miles from 77221
The Sam Houston Hotel in Houston
+1-800-997-5148Check Rates
1117 Prairie St., Houston, TX 77002
  • 4.0/5, Very Good Reviews
  • 3-star Downtown property
  • Hotel has 10 floors
~3.91 Miles from 77221
Best Western Downtown Inn & Suites in Houston
+1-800-997-5149Check Rates
915 West Dallas, Houston, TX 77019
  • 4.5/5, Very Good Reviews
  • Three Star Downtown property
  • Check-in time: 2:00PM
~3.97 Miles from 77221
The Quality Inn & Suites Reliant Park - Houston
+1-800-230-4134Check Rates
2364 South Loop West, Houston, TX 77054
  • 3.5/5, Average Latest Reviews
  • 3 star Convention Center hotel
  • Free breakfast
~3.99 Miles from 77221
The Lancaster Hotel Houston
+1-800-997-5148Check Rates
701 Texas Ave., Houston, TX 77002
  • 4-star Downtown property
  • 3 meeting rooms in property
~4.04 Miles from 77221
Crowne Plaza Houston River Oaks
+1-800-997-5149Check Rates
2712 Southwest Fwy, Houston, TX 77098
  • 4.5/5, Very Good Reviews
  • Four-star Downtown property
  • Access to gym on-site
~4.38 Miles from 77221
Four Points by Sheraton Houston Southwest - Houston
+1-800-230-4134Check Rates
2828 Southwest Fwy, Houston, TX 77098
  • 3.0/5, Average Hotel Reviews
  • Three Star Downtown hotel
  • Check-in time: 3:00 PM
~4.48 Miles from 77221
Residence Inn : 2939 Westpark Dr.
+1-800-997-5148Check Rates
2939 Westpark Dr., Houston, TX 77005
  • 4.0/5, Very Good Recent Reviews
  • 3-star Downtown property
  • Complimentary breakfast is offered
~4.48 Miles from 77221
Courtyard by Marriott Houston West University in Houston
+1-800-997-5149Check Rates
2929 Westpark Dr., Houston, TX 77005
  • 4.0/5, Very Good Latest Reviews
  • Affordable Suburban hotel
  • Access to gym on-site
~4.49 Miles from 77221
Greenway Inn & Suites
+1-800-230-4134Check Rates
2929 Southwest Freeway, Houston, TX 77098
  • 1.5/5, Terrible Review Score
  • Inexpensive Suburban property
  • Hotel has 10 suites
~4.50 Miles from 77221
La Quinta Inn Reliant / Medical Center
+1-800-997-5148Check Rates
9911 Buffalo Speedway, Houston, TX 77054
  • 3.5/5, Average Guest Reviews
  • Inexpensive Downtown property
  • Complimentary breakfast is offered
~4.54 Miles from 77221
Americas Best Value Inn - Houston
+1-800-997-5149Check Rates
9604 South Main, Houston, TX 77025
  • 3.5/5, Average Reviews
  • Low priced Convention Center hotel
  • 2 floors in hotel
~4.68 Miles from 77221
Executive Inn & Suites in Houston
+1-800-230-4134Check Rates
6711 Telephone Rd., Houston, TX 77061~4.75 Miles from 77221
Carefree Inn at the Medical Center in Houston
+1-800-997-5148Check Rates
10015 South Main St., Houston, TX 77025
  • 4.0/5, Very Good Recent Reviews
  • Low-priced Downtown hotel
  • Airport shuttle available
~4.76 Miles from 77221



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