Hotels in 77221 - Houston TX

Only hotels in 77221 zip code are listed below. Search for cheap and discount hotel rates in Houston, TX for your upcoming leisure or conference / group travel. We list the best 77221 hotels and motels so you can review the Houston hotel list below to find the perfect lodging. Hotels in Harris county and area code 713 are also listed.


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77221 Hotels & Accommodations

Image of Extended Stay America Houston Greenway PlazaExtended Stay America Houston Greenway Plaza : 2330 SW Frwy
+1-800-230-4134Check Rates
2330 SW Frwy, Houston, TX 77098
  • 3.5/5, Average Recent Reviews
  • Low-priced Downtown hotel
  • Hotel has 2 suites
~1.17 Miles from 77221
Exterior of Hilton University of HoustonHilton University of Houston
+1-800-997-5148Check Rates
4800 Calhoun Rd., Houston, TX 77004
  • 4.0/5, Very Good Recent Reviews
  • Four-star Downtown property
  • Free breakfast available
~1.41 Miles from 77221
Image of Mainstay SuitesMainstay Suites in Houston
+1-800-997-5149Check Rates
3134 Old Spanish Trail, Houston, TX 77054
  • 4.0/5, Very Good Reviews
  • Low priced Convention Center hotel
  • Complimentary breakfast is offered
~1.49 Miles from 77221
Extended Stay Deluxe Houston Medical Center : 1301 Braeswood Blvd.
+1-800-230-4134Check Rates
1301 Braeswood Blvd., Houston, TX 77030
  • 3.0/5, Average Hotel Reviews
  • 3-star Convention Center hotel
  • Hotel has 4 suites
~2.52 Miles from 77221
Photo of Hotel Zaza HoustonHotel Zaza Houston : 5701 Main St.
+1-800-997-5148Check Rates
5701 Main St., Houston, TX 77005
  • 4.5/5, Very Good Read Reviews
  • 4-star Downtown hotel
  • Hotel has 12 floors
~2.57 Miles from 77221
Image of Lexington Hotel Houston Medical CenterLexington Hotel Houston Medical Center : 1025 Swanson St.
+1-800-997-5149Check Rates
1025 Swanson St., Houston, TX 77030
  • 4.0/5, Very Good Read Reviews
  • 3 star Downtown property
  • Complimentary breakfast is offered
~2.74 Miles from 77221
Exterior of Hotel IconHotel Icon in Houston
+1-800-230-4134Check Rates
220 Main St., Houston, TX 77002
  • 4 star Downtown hotel
  • 12 floors in hotel
~2.79 Miles from 77221
Exterior of Houston Marriott Medical CenterHouston Marriott Medical Center
+1-800-997-5148Check Rates
6580 Fannin St., Houston, TX 77030
  • High-end Downtown property
  • 22 suites in hotel
~2.80 Miles from 77221
Hampton Inn & Suites Houston Medical Center : 1715 Old Spanish Trail
+1-800-997-5149Check Rates
1715 Old Spanish Trail, Houston, TX 77054
  • 4.5/5, Very Good Guest Reviews
  • 3 star Convention Center hotel
  • Free breakfast available
~2.92 Miles from 77221
Hilton Houston Plaza Medical Center
+1-800-230-4134Check Rates
6633 Travis, Houston, TX 77030
  • 4.0/5, Very Good Review Score
  • Midscale Downtown hotel
  • Check in time: 03:00 PM
~2.93 Miles from 77221
Robin's Nest Bed & Breakfast Inn
+1-800-997-5148Check Rates
4104 Greeley St., Houston, TX 77006
  • 3 star Downtown hotel
  • Hotel has 2 floors
~2.99 Miles from 77221
Wyndham Houston Medical Center Hotel & Suite
+1-800-997-5149Check Rates
6800 Main St., Houston, TX 77030
  • 4.0/5, Very Good Latest Reviews
  • 3-star Downtown hotel
  • 12 floors in hotel
~2.99 Miles from 77221
Holiday Inn Express & Suites Downtown : 1810 Bell St.
+1-800-230-4134Check Rates
1810 Bell St., Houston, TX 77003
  • 4.0/5, Very Good Review Score
  • Affordable Downtown hotel
  • Hotel has 112 rooms
~3.14 Miles from 77221
Hilton Americas Houston
+1-800-997-5148Check Rates
1600 Lamar, Houston, TX 77010
  • 4.5/5, Very Good Recent Reviews
  • High end Downtown hotel
  • Check in time: 3:00 PM
~3.32 Miles from 77221
Springhill Suites by Marriott Houston Nrg Park
+1-800-997-5149Check Rates
1400 Old Spanish Trail, Houston, TX 77054
  • Affordable Downtown hotel
  • Comp. Breakfast
~3.33 Miles from 77221
Athens Hotel
+1-800-230-4134Check Rates
1308 Clay St., Houston, TX 77002
  • 3.0/5, Average Review Score
  • Low-priced Downtown property
  • Hotel has 23 rooms
~3.41 Miles from 77221
Courtyard by Marriott Houston Medical Center in Houston
+1-800-997-5148Check Rates
Houston Medical Center 7702 Main St., Houston, TX 77030
  • 4.0/5, Very Good Guest Reviews
  • Midscale Suburban property
  • 8 suites in property
~3.48 Miles from 77221
Holiday Inn Houston Reliant Park Area - Houston
+1-800-997-5149Check Rates
8111 Kirby Dr., Houston, TX 77054
  • 3.5/5, Average Recent Reviews
  • Three Star Suburban hotel
  • Check-in: 4:00 PM
~3.51 Miles from 77221
Extended Stay America Houston Reliant Pk. La Conch - Houston
+1-800-230-4134Check Rates
1303 La Concha Ln, Houston, TX 77054
  • 3.0/5, Average Hotel Reviews
  • 3-star Convention Center hotel
  • Hotel has 45 suites
~3.52 Miles from 77221
Four Seasons Hotel Houston : 1300 Lamar St.
+1-800-997-5148Check Rates
1300 Lamar St., Houston, TX 77010
  • 4.5/5, Very Good Latest Reviews
  • Luxurious 5 Star Downtown hotel
  • Check in: 3:00 p.m.
~3.52 Miles from 77221
Moody Manor at the Houston Medical Center
+1-800-997-5149Check Rates
7706 South Main, Houston, TX 77030
  • 2 star Downtown property
  • Check in: 3:00pm
~3.53 Miles from 77221
Residence Inn by Marriott Medical Center / Reliant - Houston
+1-800-230-4134Check Rates
7710 Main St., Houston, TX 77030
  • 3.5/5, Average Reviews
  • Mid-scale Highway hotel
  • 2 floors in hotel
~3.60 Miles from 77221
Crowne Plaza Houston Downtown : 1700 Smith St.
+1-800-997-5148Check Rates
1700 Smith St., Houston, TX 77002
  • Four star Downtown property
  • Check in: 12 Noon
~3.62 Miles from 77221
Rodeway Inn Suites
+1-800-997-5149Check Rates
6712 Morningside Dr., Houston, TX 77030
  • Cheap Downtown hotel
  • Free breakfast available
~3.63 Miles from 77221
Residence Inn Houston Downtown : 904 Dallas St.
+1-800-230-4134Check Rates
904 Dallas St., Houston, TX 77002
  • 4.0/5, Very Good Recent Reviews
  • 3 star Downtown hotel
  • Fitness + Health Center
~3.64 Miles from 77221
Courtyard Houston Downtown - Houston
+1-800-997-5148Check Rates
916 Dallas St., Houston, TX 77002
  • 3.5/5, Average Hotel Reviews
  • 3 star Downtown property
  • 191 sleeping rooms in hotel
~3.64 Miles from 77221
The Westin Houston Downtown - Houston
+1-800-997-5149Check Rates
1520 Texas Ave., Houston, TX 77002~3.71 Miles from 77221
Holiday Inn Express Suites Medical Center
+1-800-230-4134Check Rates
8080 South Main St., Houston, TX 77025
  • 4.0/5, Very Good Review Score
  • 3 star Downtown hotel
  • Hotel has 35 suites
~3.72 Miles from 77221
Hyatt Regency Houston
+1-800-997-5148Check Rates
1200 Louisiana St., Houston, TX 77002
  • 4.0/5, Very Good Hotel Reviews
  • 4 star Downtown hotel
  • Check in time: 3:00 pm
~3.78 Miles from 77221
Comfort Suites
+1-800-997-5149Check Rates
1055 Mcnee Rd., Houston, TX 77054
  • 3.5/5, Average Review Score
  • 2 star Convention Center hotel
  • Check-in time: 3pm
~3.82 Miles from 77221
JW Marriott Houston Downtown
+1-800-230-4134Check Rates
806 Main, Houston, TX 77002
  • Luxury 5 star hotel
~3.82 Miles from 77221
Magnolia Hotel in Houston
+1-800-997-5148Check Rates
1100 Texas Ave., Houston, TX 77002
  • 4.5/5, Very Good Hotel Reviews
  • 4-star Downtown property
  • Fitness center on property
~3.84 Miles from 77221
Crowne Plaza Houston Near Reliant Medical in Houston
+1-800-997-5149Check Rates
8686 Kirby Dr., Houston, TX 77054
  • Mid-scale Convention Center property
  • 652 sleeping rooms in hotel
~3.86 Miles from 77221
Doubletree Houston Downtown
+1-800-230-4134Check Rates
400 Dallas St., Houston, TX 77002
  • 4.0/5, Very Good Guest Reviews
  • 3-star Downtown property
  • Hotel has 20 floors
~3.89 Miles from 77221
The Sam Houston Hotel
+1-800-997-5148Check Rates
1117 Prairie St., Houston, TX 77002
  • 4.0/5, Very Good Hotel Reviews
  • High-end Downtown hotel
  • Hotel has 100 rooms
~3.91 Miles from 77221
Best Western Downtown Inn & Suites - Houston
+1-800-997-5149Check Rates
915 West Dallas, Houston, TX 77019
  • 4.5/5, Very Good Review Score
  • Mid-scale Downtown hotel
  • Complimentary breakfast is offered
~3.97 Miles from 77221
The Quality Inn & Suites Reliant Park
+1-800-230-4134Check Rates
2364 South Loop West, Houston, TX 77054
  • 3.5/5, Average Reviews
  • 3 star Convention Center hotel
  • 2 floors in hotel
~3.99 Miles from 77221
The Lancaster Hotel Houston in Houston
+1-800-997-5148Check Rates
701 Texas Ave., Houston, TX 77002
  • Expensive Downtown hotel
  • Check in time: 3:00 pm
~4.04 Miles from 77221
Crowne Plaza Houston River Oaks in Houston
+1-800-997-5149Check Rates
2712 Southwest Fwy, Houston, TX 77098
  • 4.5/5, Very Good Latest Reviews
  • Four star Downtown property
  • Check in: 3:00 PM
~4.38 Miles from 77221
Residence Inn
+1-800-230-4134Check Rates
2939 Westpark Dr., Houston, TX 77005
  • 4.0/5, Very Good Hotel Reviews
  • Midscale Downtown property
  • Check-in: 03:00pm
~4.48 Miles from 77221
Courtyard by Marriott Houston West University - Houston
+1-800-997-5148Check Rates
2929 Westpark Dr., Houston, TX 77005
  • 4.0/5, Very Good Latest Reviews
  • 3 star Suburban property
  • Gym / Fitness Center Available
~4.49 Miles from 77221
Four Points by Sheraton Houston Southwest
+1-800-997-5149Check Rates
2828 Southwest Freeway, Houston, TX 77098
  • 3-star Downtown hotel
  • Check in: 3:00 PM
~4.50 Miles from 77221
Greenway Inn & Suites - Houston
+1-800-230-4134Check Rates
2929 Southwest Freeway, Houston, TX 77098
  • 1.5/5, Terrible Hotel Reviews
  • 2-star Suburban hotel
  • 4 floors in property
~4.50 Miles from 77221
La Quinta Inn Reliant / Medical Center : 9911 Buffalo Speedway
+1-800-997-5148Check Rates
9911 Buffalo Speedway, Houston, TX 77054~4.54 Miles from 77221
Americas Best Value Inn - Houston
+1-800-997-5149Check Rates
9604 South Main, Houston, TX 77025
  • 3.5/5, Average Hotel Reviews
  • Economical Convention Center hotel
  • Hotel has 135 rooms
~4.68 Miles from 77221
Executive Inn & Suites
+1-800-230-4134Check Rates
6711 Telephone Rd., Houston, TX 77061~4.75 Miles from 77221
Carefree Inn at the Medical Center - Houston
+1-800-997-5148Check Rates
10015 South Main St., Houston, TX 77025
  • 4.0/5, Very Good Review Score
  • Cheap Downtown hotel
  • Free breakfast
~4.76 Miles from 77221
Motel 6 Houston Reliant Park #1126 : 3223 South Loop West
+1-800-997-5149Check Rates
3223 South Loop West, Houston, TX 77025
  • Cheap hotel
  • Hotel has 3 floors
~4.77 Miles from 77221
Candlewood Suites Houston Medical Center
+1-800-230-4134Check Rates
10025 South Main St., Houston, TX 77025
  • 4.0/5, Very Good Recent Reviews
  • 2-star Highway property
  • 80 rooms in property
~4.83 Miles from 77221
Doubletree by Hilton Houston Greenway Plaza - Houston
+1-800-997-5148Check Rates
6 Greenway Plaza, Houston, TX 77046
  • High end Highway property
  • 388 sleeping rooms in hotel
~5.01 Miles from 77221



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