Hotels in 77221 - Houston TX

Only hotels in 77221 zip code are listed below. Search for cheap and discount hotel rates in Houston, TX for your upcoming leisure or conference / group travel. We list the best 77221 hotels and motels so you can review the Houston hotel list below to find the perfect lodging. Hotels in Harris county and area code 713 are also listed.


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77221 Hotels & Accommodations

Exterior of Extended Stay America Houston Greenway PlazaExtended Stay America Houston Greenway Plaza
+1-800-230-4134Check Rates
2330 SW Frwy, Houston, TX 77098
  • 3.5/5, Average Recent Reviews
  • 2-star Downtown hotel
  • 122 sleeping rooms in hotel
~1.17 Miles from 77221
Photo of Hilton University of HoustonHilton University of Houston : 4800 Calhoun Rd.
+1-800-997-5148Check Rates
4800 Calhoun Rd., Houston, TX 77004
  • 4.0/5, Very Good Guest Reviews
  • Four star Downtown hotel
  • Fitness / Gym is on-site
~1.41 Miles from 77221
Image of Mainstay SuitesMainstay Suites
+1-800-997-5149Check Rates
3134 Old Spanish Trail, Houston, TX 77054
  • 4.0/5, Very Good Guest Reviews
  • Two star Convention Center property
  • Hotel has 92 suites
~1.49 Miles from 77221
Extended Stay Deluxe Houston Medical Center
+1-800-230-4134Check Rates
1301 Braeswood Blvd., Houston, TX 77030
  • 3.0/5, Average Latest Reviews
  • Mid-scale Convention Center property
  • Check in time: 3:00pm
~2.52 Miles from 77221
Exterior of Hotel Zaza HoustonHotel Zaza Houston
+1-800-997-5148Check Rates
5701 Main St., Houston, TX 77005
  • 4.5/5, Very Good Read Reviews
  • 4 star Downtown property
  • Fitness center on property
~2.57 Miles from 77221
Photo of Lexington Hotel Houston Medical CenterLexington Hotel Houston Medical Center : 1025 Swanson St.
+1-800-997-5149Check Rates
1025 Swanson St., Houston, TX 77030
  • 4.0/5, Very Good Hotel Reviews
  • Midscale Downtown hotel
  • Check in time: 3:00 PM
~2.74 Miles from 77221
Image of Houston Marriott Medical Center HotelHouston Marriott Medical Center Hotel
+1-800-230-4134Check Rates
6580 Fannin, Houston, TX 77030
  • 4.0/5, Very Good Guest Reviews
  • Four star Downtown property
  • 21 suites in property
~2.77 Miles from 77221
Image of Hotel IconHotel Icon in Houston
+1-800-997-5148Check Rates
220 Main St., Houston, TX 77002
  • 4 star Downtown hotel
  • Gym is available on property
~2.79 Miles from 77221
Houston Marriott at the Texas Medical Center
+1-800-997-5149Check Rates
6580 Fannin Steet, Houston, TX 77030~2.80 Miles from 77221
Hampton Inn & Suites Houston Medical Center in Houston
+1-800-230-4134Check Rates
1715 Old Spanish Trail, Houston, TX 77054
  • 4.5/5, Very Good Reviews
  • Three Star Convention Center hotel
  • Free breakfast
~2.92 Miles from 77221
Hilton Houston Plaza Medical Center : 6633 Travis
+1-800-997-5148Check Rates
6633 Travis, Houston, TX 77030
  • 4.0/5, Very Good Guest Reviews
  • Midscale Downtown hotel
  • 145 suites in hotel
~2.93 Miles from 77221
Robin's Nest Bed & Breakfast Inn : 4104 Greeley St.
+1-800-997-5149Check Rates
4104 Greeley St., Houston, TX 77006
  • 4.5/5, Very Good Reviews
  • Cheap Downtown property
  • 2 conference rooms in property
~2.99 Miles from 77221
Wyndham Houston Medical Center Hotel & Suite - Houston
+1-800-230-4134Check Rates
6800 Main St., Houston, TX 77030
  • 4.0/5, Very Good Latest Reviews
  • Midscale Downtown hotel
  • Check-in: 3:00PM
~2.99 Miles from 77221
Homestead Studio Suites
+1-800-997-5148Check Rates
7979 Fannin, Houston, TX 77054
  • Inexpensive Downtown hotel
  • 153 rooms in hotel
~3.02 Miles from 77221
Holiday Inn Express & Suites Downtown : 1810 Bell St.
+1-800-997-5149Check Rates
1810 Bell St., Houston, TX 77003
  • 4.0/5, Very Good Hotel Reviews
  • Mid-scale Downtown property
  • Hotel has 112 rooms
~3.14 Miles from 77221
Hilton Americas Houston in Houston
+1-800-230-4134Check Rates
1600 Lamar, Houston, TX 77010~3.32 Miles from 77221
Springhill Suites by Marriott Houston Nrg Park : 1400 Old Spanish Trail
+1-800-997-5148Check Rates
1400 Old Spanish Trail, Houston, TX 77054
  • 3 star Downtown hotel
  • 7 floors in property
~3.33 Miles from 77221
Athens Hotel : 1308 Clay St.
+1-800-997-5149Check Rates
1308 Clay St., Houston, TX 77002
  • 3.0/5, Average Read Reviews
  • 2 star Downtown property
  • Fitness + Health Center
~3.41 Miles from 77221
Courtyard by Marriott Houston Medical Center in Houston
+1-800-230-4134Check Rates
Houston Medical Center 7702 Main St., Houston, TX 77030
  • 4.0/5, Very Good Read Reviews
  • Affordable Suburban hotel
  • Check-in time: 3:00 PM
~3.48 Miles from 77221
Holiday Inn Houston Reliant Park Area in Houston
+1-800-997-5148Check Rates
8111 Kirby Dr., Houston, TX 77054
  • 3.5/5, Average Hotel Reviews
  • Three Star Suburban property
  • Hotel has 238 rooms
~3.51 Miles from 77221
Extended Stay America Houston Reliant Pk. La Conch in Houston
+1-800-997-5149Check Rates
1303 La Concha Ln, Houston, TX 77054
  • 3.0/5, Average Reviews
  • Midscale Convention Center property
  • Check in time: 3pm
~3.52 Miles from 77221
Four Seasons Hotel Houston
+1-800-230-4134Check Rates
1300 Lamar St., Houston, TX 77010
  • 4.5/5, Very Good Review Score
  • Luxury 5-star Downtown hotel
  • 25 floors in property
~3.52 Miles from 77221
Moody Manor at the Houston Medical Center : 7706 South Main
+1-800-997-5148Check Rates
7706 South Main, Houston, TX 77030
  • 2 star Downtown hotel
  • 14 suites in hotel
~3.53 Miles from 77221
Residence Inn by Marriott Medical Center / Reliant
+1-800-997-5149Check Rates
7710 Main St., Houston, TX 77030
  • 3.5/5, Average Reviews
  • Mid-scale Highway property
  • Hotel has 2 floors
~3.60 Miles from 77221
Crowne Plaza Houston Downtown - Houston
+1-800-230-4134Check Rates
1700 Smith St., Houston, TX 77002
  • Expensive Downtown hotel
  • 12 floors in property
~3.62 Miles from 77221
Rodeway Inn Suites - Houston
+1-800-997-5148Check Rates
6712 Morningside Dr., Houston, TX 77030
  • Cheap Downtown hotel
  • 2 floors in hotel
~3.63 Miles from 77221
Courtyard Houston Downtown in Houston
+1-800-997-5149Check Rates
916 Dallas St., Houston, TX 77002
  • 3.5/5, Average Review Score
  • 3-star Downtown property
  • 9 floors in property
~3.64 Miles from 77221
Residence Inn Houston Downtown - Houston
+1-800-230-4134Check Rates
904 Dallas St., Houston, TX 77002
  • 4.0/5, Very Good Recent Reviews
  • 3-star Downtown property
  • Hotel has 10 floors
~3.64 Miles from 77221
Parkview Inn & Suites in Houston
+1-800-997-5148Check Rates
9000 South Main, Houston, TX 77025
  • Cheap property
~3.68 Miles from 77221
The Westin Houston Downtown
+1-800-997-5149Check Rates
1520 Texas Ave., Houston, TX 77002~3.71 Miles from 77221
Holiday Inn Express Suites Medical Center
+1-800-230-4134Check Rates
8080 South Main St., Houston, TX 77025
  • 4.0/5, Very Good Review Score
  • 3 star Downtown hotel
  • Comp. Breakfast
~3.72 Miles from 77221
Hyatt Regency Houston : 1200 Louisiana St.
+1-800-997-5148Check Rates
1200 Louisiana St., Houston, TX 77002
  • 4.0/5, Very Good Latest Reviews
  • High-end Downtown property
  • 947 rooms in hotel
~3.78 Miles from 77221
Comfort Suites - Houston
+1-800-997-5149Check Rates
1055 Mcnee Rd., Houston, TX 77054
  • 3.5/5, Average Review Score
  • Low Cost Convention Center property
  • Check-in: 3pm
~3.82 Miles from 77221
JW Marriott Houston Downtown
+1-800-230-4134Check Rates
806 Main, Houston, TX 77002
  • Luxurious 5 Star hotel
~3.82 Miles from 77221
Magnolia Hotel - Houston
+1-800-997-5148Check Rates
1100 Texas Ave., Houston, TX 77002
  • 4.5/5, Very Good Hotel Reviews
  • High-end Downtown hotel
  • Check-in: 3:00 PM
~3.84 Miles from 77221
Crowne Plaza Houston Near Reliant Medical : 8686 Kirby Dr.
+1-800-997-5149Check Rates
8686 Kirby Dr., Houston, TX 77054
  • 3.0/5, Average Read Reviews
  • Midscale Convention Center property
  • Hotel has 70 suites
~3.86 Miles from 77221
Doubletree Houston Downtown
+1-800-230-4134Check Rates
400 Dallas St., Houston, TX 77002
  • 4.0/5, Very Good Guest Reviews
  • Mid-scale Downtown property
  • Hotel has 20 floors
~3.89 Miles from 77221
The Sam Houston Hotel in Houston
+1-800-997-5148Check Rates
1117 Prairie St., Houston, TX 77002
  • 4.0/5, Very Good Recent Reviews
  • Mid-scale Downtown hotel
  • Hotel has 10 floors
~3.91 Miles from 77221
Best Western Downtown Inn & Suites : 915 West Dallas
+1-800-997-5149Check Rates
915 West Dallas, Houston, TX 77019
  • 4.5/5, Very Good Reviews
  • Mid-scale Downtown hotel
  • Check in: 2:00PM
~3.97 Miles from 77221
The Quality Inn & Suites Reliant Park - Houston
+1-800-230-4134Check Rates
2364 South Loop West, Houston, TX 77054
  • 3.5/5, Average Read Reviews
  • Midscale Convention Center property
  • 106 rooms in property
~3.99 Miles from 77221
The Lancaster Hotel Houston
+1-800-997-5148Check Rates
701 Texas Ave., Houston, TX 77002
  • Four-star Downtown property
  • Hotel has 3 meeting rooms
~4.04 Miles from 77221
Crowne Plaza Houston River Oaks : 2712 Southwest Fwy
+1-800-997-5149Check Rates
2712 Southwest Fwy, Houston, TX 77098
  • 4.5/5, Very Good Hotel Reviews
  • Four-star Downtown hotel
  • Hotel has 36 suites
~4.38 Miles from 77221
Four Points by Sheraton Houston Southwest
+1-800-230-4134Check Rates
2828 Southwest Fwy, Houston, TX 77098
  • 3.0/5, Average Latest Reviews
  • Affordable Downtown hotel
  • Check in time: 3:00 PM
~4.48 Miles from 77221
Residence Inn : 2939 Westpark Dr.
+1-800-997-5148Check Rates
2939 Westpark Dr., Houston, TX 77005
  • 4.0/5, Very Good Recent Reviews
  • Mid-scale Downtown property
  • Access to gym on-site
~4.48 Miles from 77221
Courtyard by Marriott Houston West University
+1-800-997-5149Check Rates
2929 Westpark Dr., Houston, TX 77005
  • 4.0/5, Very Good Review Score
  • Midscale Suburban property
  • 100 sleeping rooms in hotel
~4.49 Miles from 77221
Greenway Inn & Suites : 2929 Southwest Freeway
+1-800-230-4134Check Rates
2929 Southwest Freeway, Houston, TX 77098
  • 1.5/5, Terrible Latest Reviews
  • Cheap Suburban property
  • 10 suites in hotel
~4.50 Miles from 77221
La Quinta Inn Reliant / Medical Center - Houston
+1-800-997-5148Check Rates
9911 Buffalo Speedway, Houston, TX 77054
  • 3.5/5, Average Guest Reviews
  • Low-priced Downtown property
  • 113 rooms in hotel
~4.54 Miles from 77221
Americas Best Value Inn
+1-800-997-5149Check Rates
9604 South Main, Houston, TX 77025
  • 3.5/5, Average Latest Reviews
  • Low-priced Convention Center hotel
  • 2 floors in hotel
~4.68 Miles from 77221
Executive Inn & Suites - Houston
+1-800-230-4134Check Rates
6711 Telephone Rd., Houston, TX 77061~4.75 Miles from 77221
Carefree Inn at the Medical Center : 10015 South Main St.
+1-800-997-5148Check Rates
10015 South Main St., Houston, TX 77025
  • 4.0/5, Very Good Guest Reviews
  • Low priced Downtown property
  • 2 meeting rooms in hotel
~4.76 Miles from 77221



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