Hotels in 77221 Houston (Texas)

Hotels in 77221 - Houston TX

Only hotels in 77221 zip code are listed below. Search for cheap and discount hotel rates in Houston, TX for your upcoming leisure or conference / group travel. We list the best 77221 hotels and motels so you can review the Houston hotel list below to find the perfect lodging. Hotels in Harris county and area code 713 are also listed.


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77221 Hotels, Motels & Accommodations

Photo of Extended Stay America Houston Greenway PlazaExtended Stay America Houston Greenway Plaza - Houston
+1-800-230-4134Check Rates
2330 SW Frwy, Houston, TX 77098
  • 3.5/5, Average Review Score
  • 2-star Downtown hotel
  • Access to gym on-site
~1.17 Miles from 77221
Photo of Hilton University of HoustonHilton University of Houston
+1-800-997-5148Check Rates
4800 Calhoun Rd., Houston, TX 77004
  • 4.0/5, Very Good Hotel Reviews
  • 4-star Downtown property
  • Check-in time: 3:00PM
~1.41 Miles from 77221
Exterior of Mainstay SuitesMainstay Suites
+1-800-997-5149Check Rates
3134 Old Spanish Trail, Houston, TX 77054
  • 4.0/5, Very Good Hotel Reviews
  • Inexpensive Convention Center property
  • Access to gym on-site
~1.49 Miles from 77221
Extended Stay Deluxe Houston Medical Center : 1301 Braeswood Blvd.
+1-800-230-4134Check Rates
1301 Braeswood Blvd., Houston, TX 77030
  • 3.0/5, Average Latest Reviews
  • Affordable Convention Center property
  • Check in time: 3:00pm
~2.52 Miles from 77221
Image of Hotel Zaza HoustonHotel Zaza Houston
+1-800-997-5148Check Rates
5701 Main St., Houston, TX 77005
  • 4.5/5, Very Good Latest Reviews
  • High end Downtown property
  • Gym / Fitness Center Available
~2.57 Miles from 77221
Exterior of Lexington Hotel Houston Medical CenterLexington Hotel Houston Medical Center in Houston
+1-800-997-5149Check Rates
1025 Swanson St., Houston, TX 77030
  • 4.0/5, Very Good Hotel Reviews
  • 3-star Downtown hotel
  • Free breakfast
~2.74 Miles from 77221
Image of Houston Marriott Medical Center HotelHouston Marriott Medical Center Hotel : 6580 Fannin
+1-800-230-4134Check Rates
6580 Fannin, Houston, TX 77030
  • 4.0/5, Very Good Guest Reviews
  • 4 star Downtown hotel
  • 26 floors in property
~2.77 Miles from 77221
Image of Hotel IconHotel Icon
+1-800-997-5148Check Rates
220 Main St., Houston, TX 77002
  • 4 star Downtown property
  • Hotel has 15 suites
~2.79 Miles from 77221
Houston Marriott at the Texas Medical Center
+1-800-997-5149Check Rates
6580 Fannin Steet, Houston, TX 77030~2.80 Miles from 77221
Hampton Inn & Suites Houston Medical Center : 1715 Old Spanish Trail
+1-800-230-4134Check Rates
1715 Old Spanish Trail, Houston, TX 77054
  • 4.5/5, Very Good Hotel Reviews
  • 3 star Convention Center property
  • Gym / Fitness Center Available
~2.92 Miles from 77221
Best Western Plaza Hotel & Suites Medical Center : 6700 South Main St.
+1-800-997-5148Check Rates
6700 South Main St., Houston, TX 77030
  • 3.5/5, Average Read Reviews
  • 3-star Downtown property
  • Check in: 03:00 pm
~2.92 Miles from 77221
Hilton Houston Plaza Medical Center in Houston
+1-800-997-5149Check Rates
6633 Travis, Houston, TX 77030
  • 4.0/5, Very Good Reviews
  • 3-star Downtown hotel
  • Hotel has 19 floors
~2.93 Miles from 77221
Robin's Nest Bed & Breakfast Inn
+1-800-230-4134Check Rates
4104 Greeley St., Houston, TX 77006
  • 4.5/5, Very Good Review Score
  • 2-star Downtown property
  • Hotel has 9 rooms
~2.99 Miles from 77221
Wyndham Houston Medical Center Hotel & Suite
+1-800-997-5148Check Rates
6800 Main St., Houston, TX 77030
  • 4.0/5, Very Good Recent Reviews
  • Midscale Downtown property
  • Hotel has 215 suites
~2.99 Miles from 77221
Homestead Studio Suites : 7979 Fannin
+1-800-997-5149Check Rates
7979 Fannin, Houston, TX 77054
  • Economical Downtown hotel
  • 153 sleeping rooms in hotel
~3.02 Miles from 77221
Holiday Inn Express & Suites Downtown
+1-800-230-4134Check Rates
1810 Bell St., Houston, TX 77003
  • 4.0/5, Very Good Read Reviews
  • Affordable Downtown hotel
  • 22 suites in property
~3.14 Miles from 77221
Hilton Americas Houston : 1600 Lamar
+1-800-997-5148Check Rates
1600 Lamar, Houston, TX 77010
  • 4.5/5, Very Good Guest Reviews
  • Four-star Downtown property
  • Gym / Fitness Center Available
~3.32 Miles from 77221
Springhill Suites Houston Medical Center / Reliant - Houston
+1-800-997-5149Check Rates
1400 Old Spanish Trail, Houston, TX 77054
  • 4.0/5, Very Good Latest Reviews
  • Affordable Downtown hotel
  • 190 rooms in property
~3.33 Miles from 77221
Athens Hotel in Houston
+1-800-230-4134Check Rates
1308 Clay St., Houston, TX 77002
  • 3.5/5, Average Reviews
  • Two-star Downtown hotel
  • Check in: 2PM
~3.41 Miles from 77221
Courtyard by Marriott Houston Medical Center
+1-800-997-5148Check Rates
Houston Medical Center 7702 Main St., Houston, TX 77030
  • 4.0/5, Very Good Latest Reviews
  • 3-star Suburban hotel
  • Fitness / Gym is on-site
~3.48 Miles from 77221
Holiday Inn Houston Reliant Park Area
+1-800-997-5149Check Rates
8111 Kirby Dr., Houston, TX 77054
  • 3.5/5, Average Hotel Reviews
  • Three Star Suburban property
  • 11 floors in hotel
~3.51 Miles from 77221
Extended Stay America Houston Reliant Pk. La Conch
+1-800-230-4134Check Rates
1303 La Concha Ln, Houston, TX 77054
  • 3.0/5, Average Read Reviews
  • 3-star Convention Center hotel
  • Hotel has 84 rooms
~3.52 Miles from 77221
Four Seasons Hotel Houston : 1300 Lamar St.
+1-800-997-5148Check Rates
1300 Lamar St., Houston, TX 77010
  • 4.5/5, Very Good Latest Reviews
  • Luxurious 5-star Downtown property
  • 115 suites in hotel
~3.52 Miles from 77221
Moody Manor at the Houston Medical Center - Houston
+1-800-997-5149Check Rates
7706 South Main, Houston, TX 77030
  • 2 star Downtown property
  • Check-in time: 3:00pm
~3.53 Miles from 77221
Residence Inn by Marriott Medical Center / Reliant - Houston
+1-800-230-4134Check Rates
7710 Main St., Houston, TX 77030
  • 3.5/5, Average Hotel Reviews
  • Midscale Highway hotel
  • Complimentary breakfast is offered
~3.60 Miles from 77221
Image of Crowne Plaza Houston DowntownCrowne Plaza Houston Downtown
+1-800-997-5148Check Rates
1700 Smith St., Houston, TX 77002
  • 4.0/5, Very Good Reviews
  • 4 star Downtown hotel
  • 13 conference rooms in property
~3.62 Miles from 77221
Rodeway Inn Suites
+1-800-997-5149Check Rates
6712 Morningside Dr., Houston, TX 77030
  • Low Cost Downtown property
  • Hotel has 31 suites
~3.63 Miles from 77221
Residence Inn Houston Downtown - Houston
+1-800-230-4134Check Rates
904 Dallas St., Houston, TX 77002
  • 4.0/5, Very Good Guest Reviews
  • 3 star Downtown hotel
  • Access to gym on-site
~3.64 Miles from 77221
Courtyard Houston Downtown : 916 Dallas St.
+1-800-997-5148Check Rates
916 Dallas St., Houston, TX 77002
  • 3.5/5, Average Hotel Reviews
  • 3-star Downtown property
  • 6 suites in property
~3.64 Miles from 77221
Parkview Inn & Suites - Houston
+1-800-997-5149Check Rates
9000 South Main, Houston, TX 77025
  • Economical hotel
~3.68 Miles from 77221
The Westin Houston Downtown - Houston
+1-800-230-4134Check Rates
1520 Texas Ave., Houston, TX 77002
  • 4.5/5, Very Good Hotel Reviews
  • Four-star Downtown property
  • Gym / Fitness Center Available
~3.71 Miles from 77221
Holiday Inn Express Suites Medical Center
+1-800-997-5148Check Rates
8080 South Main St., Houston, TX 77025
  • 4.0/5, Very Good Hotel Reviews
  • Midscale Downtown hotel
  • Check in: 3:pm
~3.72 Miles from 77221
Hyatt Regency Houston in Houston
+1-800-997-5149Check Rates
1200 Louisiana St., Houston, TX 77002
  • 4.0/5, Very Good Latest Reviews
  • Four-star Downtown hotel
  • 947 rooms in hotel
~3.78 Miles from 77221
Comfort Suites
+1-800-230-4134Check Rates
1055 Mcnee Rd., Houston, TX 77054
  • 3.5/5, Average Reviews
  • Two-star Convention Center hotel
  • Hotel has 50 rooms
~3.82 Miles from 77221
Magnolia Hotel
+1-800-997-5148Check Rates
1100 Texas Ave., Houston, TX 77002
  • 4.5/5, Very Good Read Reviews
  • Expensive Downtown property
  • Hotel has 7 meeting rooms
~3.84 Miles from 77221
Crowne Plaza Houston Near Reliant Medical in Houston
+1-800-997-5149Check Rates
8686 Kirby Dr., Houston, TX 77054
  • 3.0/5, Average Read Reviews
  • Mid-scale Convention Center property
  • Check-in: 12pm
~3.86 Miles from 77221
Doubletree Houston Downtown
+1-800-230-4134Check Rates
400 Dallas St., Houston, TX 77002
  • 4.0/5, Very Good Read Reviews
  • 3-star Downtown hotel
  • Airport shuttle available
~3.89 Miles from 77221
The Sam Houston Hotel : 1117 Prairie St.
+1-800-997-5148Check Rates
1117 Prairie St., Houston, TX 77002
  • 4.0/5, Very Good Hotel Reviews
  • Affordable Downtown property
  • Hotel has 10 floors
~3.91 Miles from 77221
Best Western Downtown Inn & Suites - Houston
+1-800-997-5149Check Rates
915 West Dallas, Houston, TX 77019
  • 4.5/5, Very Good Recent Reviews
  • Three Star Downtown hotel
  • Comp. Breakfast
~3.97 Miles from 77221
The Quality Inn & Suites Reliant Park
+1-800-230-4134Check Rates
2364 South Loop West, Houston, TX 77054
  • 3.5/5, Average Guest Reviews
  • 3 star Convention Center property
  • Hotel has 2 floors
~3.99 Miles from 77221
The Lancaster Hotel Houston
+1-800-997-5148Check Rates
701 Texas Ave., Houston, TX 77002
  • Four-star Downtown property
  • Gym / Fitness Center Available
~4.04 Miles from 77221
Crowne Plaza Houston River Oaks
+1-800-997-5149Check Rates
2712 Southwest Fwy, Houston, TX 77098
  • 4.5/5, Very Good Review Score
  • High end Downtown hotel
  • Hotel has 8 meeting rooms
~4.38 Miles from 77221
Four Points by Sheraton Houston Southwest in Houston
+1-800-230-4134Check Rates
2828 Southwest Fwy, Houston, TX 77098
  • 3.0/5, Average Reviews
  • Three Star Downtown hotel
  • 4 meeting rooms in hotel
~4.48 Miles from 77221
Residence Inn : 2939 Westpark Dr.
+1-800-997-5148Check Rates
2939 Westpark Dr., Houston, TX 77005
  • 4.0/5, Very Good Hotel Reviews
  • Affordable Downtown hotel
  • 120 sleeping rooms in hotel
~4.48 Miles from 77221
Courtyard by Marriott Houston West University
+1-800-997-5149Check Rates
2929 Westpark Dr., Houston, TX 77005
  • 4.0/5, Very Good Recent Reviews
  • 3-star Suburban property
  • Check-in time: 3:00
~4.49 Miles from 77221
Greenway Inn & Suites
+1-800-230-4134Check Rates
2929 Southwest Freeway, Houston, TX 77098~4.50 Miles from 77221
La Quinta Inn Reliant / Medical Center - Houston
+1-800-997-5148Check Rates
9911 Buffalo Speedway, Houston, TX 77054
  • 3.5/5, Average Hotel Reviews
  • Economy Downtown property
  • 113 rooms in hotel
~4.54 Miles from 77221
Americas Best Value Inn in Houston
+1-800-997-5149Check Rates
9604 South Main, Houston, TX 77025
  • 3.5/5, Average Recent Reviews
  • Two-star Convention Center property
  • 2 floors in property
~4.68 Miles from 77221
Executive Inn & Suites - Houston
+1-800-230-4134Check Rates
6711 Telephone Rd., Houston, TX 77061~4.75 Miles from 77221
Carefree Inn at the Medical Center in Houston
+1-800-997-5148Check Rates
10015 South Main St., Houston, TX 77025
  • 4.0/5, Very Good Reviews
  • Cheap Downtown hotel
  • 53 rooms in hotel
~4.76 Miles from 77221



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