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Desoto Missouri Accommodations

Find hotels in Desoto using the list and search tools below. Search for the cheapest discounted hotel and motel rates in or near Desoto, MO for your corporate or personal leisure travel. We show the best Desoto Missouri hotel rooms. Review the Desoto hotel list below to find the perfect lodging. We also have a map of the Desoto hotels.

Desoto Hotels/Accommodations

Holiday Inn Club Vac Timber Creek
+1-888-389-4121
4800 Us Highway 67, Desoto, MO 63020
  • Three Star hotel
  • Check-in time: 16:00
From$90
Very Good 4.5 /5 Review Score Call BookMore Details
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Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS, an I
+1-888-675-2083
1802 Gamel Cemetery Rd., Festus, MO 63028 ~9.29 miles northeast of Desoto
  • 2 star Highway property
  • Check in time: 3:00pm
From$90
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Comfort Inn Festus - St Louis South
+1-800-716-8490
1303 Veterans Blvd., Festus, MO 63028 Website ~9.49 miles northeast of Desoto
  • Three Star Suburban property
  • Comp. Breakfast
From$45
Very Good 4.0 /5 Reviews Call BookMore Details
Quality Inn Festus in Festus
+1-800-805-5223
1200 West Gannon Dr., Festus, MO 63028 Website ~9.52 miles northeast of Desoto
  • 3 star Suburban hotel
  • Fitness + Health Center
From$72
Average 3.0 /5 Guest Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham Festus - St. Louis South in Festus
+1-888-965-1860
1001 Veterans Blvd., Festus, MO 63028 ~9.71 miles northeast of Desoto
  • 3 star Suburban property
  • Fitness / Gym is on-site
From$80
Average 3.0 /5 Review Score Call BookMore Details
Super 8 by Wyndham Pevely in Pevely
+1-888-788-5576
1711 Highway Z, Pevely, MO 63070 ~13.04 miles northeast of Desoto
  • Two star property
From$35
Very Good 4.0 /5 Review Score Call BookMore Details
Super 8 by Wyndham Bonne Terre
+1-888-897-9207
8 Northwood Dr., Bonne Terre, MO 63628 ~14.95 miles south of Desoto
  • 2 star hotel
  • Check-in time: 11:00 AM
From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
Motel 6 Bonne Terre Mo : 1017 Highway K
+1-888-311-4278
1017 Highway K, Bonne Terre, MO 63628 ~15.14 miles south of Desoto
  • Cheap hotel
From$60
Average 3.0 /5 Hotel Reviews Call BookMore Details
Super 8 by Wyndham Potosi - Potosi
+1-888-469-4795
820 East High St., Potosi, MO 63664 ~18.93 miles southwest of Desoto
  • Economical Highway property
  • 3 suites in property
From$49
Average 3.0 /5 Guest Reviews Call BookMore Details
Quality Inn & Suites - Arnold
+1-888-734-9421
3610 West Outer Rd., Arnold, MO 63010 ~20.99 miles northeast of Desoto
  • 2 star Suburban property
  • Complimentary breakfast is offered
From$60
Average 3.0 /5 Hotel Reviews Call BookMore Details
Woodspring Suites St. Louis Arnold
+1-888-841-5292
888 Arnold Commons Dr., Arnold, MO 63010 ~22.48 miles northeast of Desoto
  • Low priced Highway hotel
  • Hotel has 124 rooms
From$32
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Drury Inn & Suites St. Louis Arnold
+1-888-455-5160
3800 State Rt 141, Arnold, MO 63010 ~22.60 miles northeast of Desoto
  • Midscale Suburban hotel
  • Check-in: 3:00 pm
From$123
Excellent 5.0 /5 Read Reviews Call BookMore Details
Pear Tree Inn St. Louis Arnold in Arnold
+1-888-965-8297
1201 Drury Lane, Arnold, MO 63010 ~23.18 miles northeast of Desoto
  • 3-star Suburban property
  • Free complimentary breakfast
From$80
Very Good 4.0 /5 Read Reviews Call BookMore Details
Crown Pointe Lodge, BW Signature Collection
+1-888-906-6358
4245 Hunt Rd., Farmington, MO 63640 ~23.30 miles south of Desoto
  • 3-star Golf Course property
  • Hotel has 48 rooms
From$65
Very Good 4.0 /5 Review Score Call BookMore Details
Best Western St. Louis Inn
+1-888-749-6785
6224 Heimos Industrial Park Dr., Saint Louis, MO 63129 ~24.45 miles northeast of Desoto
  • Economy Suburban hotel
  • Free breakfast
From$41
Average 3.0 /5 Reviews Call BookMore Details
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Hampton Inn Farmington - Farmington
+1-888-878-9982
850 Valley Creek Dr., Farmington, MO 63640 ~24.74 miles south of Desoto
  • Affordable Highway property
  • Hotel has 6 meeting rooms
From$80
Average 3.0 /5 Hotel Reviews Call BookMore Details
Super 8 by Wyndham Farmington in Farmington
+1-888-389-4485
930 Valley Creek Dr., Farmington, MO 63640 ~24.81 miles south of Desoto
  • Inexpensive hotel
  • 2 floors in property
From$49
Average 3.0 /5 Latest Reviews Call BookMore Details
Holiday Inn Express & Suites Farmington, an IHG Hotel
+1-888-389-4121
820 Market St., Farmington, MO 63640 ~24.84 miles south of Desoto
  • 3 star Rural hotel
  • 20 suites in hotel
From$99
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Fairfield by Marriott : 1680 Fenton Business Park Court
+1-888-675-2083
1680 Fenton Business Park Court, Fenton, MO 63026 ~25.52 miles north of Desoto
  • Affordable Suburban hotel
  • Gym / Fitness Center Available
From$80
Average 3.0 /5 Read Reviews Call BookMore Details
Quality Inn Farmington - Farmington
+1-800-716-8490
1400 West Liberty St., Farmington, MO 63640 ~25.67 miles south of Desoto
  • Three Star Rural property
  • 48 rooms in property
From$80
Average 3.0 /5 Hotel Reviews Call BookMore Details
America's Best Inn Eureka in Eureka
+1-800-805-5223
1725 West 5th St., Eureka, MO 63025 ~25.91 miles north of Desoto
  • Economical Highway property
  • Check-in: 11.00am
Super 8 by Wyndham Eureka/Six Flags Nearby : 1733 West 5th St.
+1-888-965-1860
1733 West 5th St., Eureka, MO 63025 ~25.97 miles north of Desoto
  • Low-priced Highway hotel
  • Check-in time: ex. 3:00 PM
From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
Baymont Inn and Suites by Wyndham Farmington, MO - Farmington
+1-888-788-5576
1625 West Columbia St., Farmington, MO 63640 ~26.01 miles south of Desoto
  • Affordable Highway hotel
  • 94 rooms in property
From$80
Average 3.0 /5 Recent Reviews Call BookMore Details
Fairfield Inn N Ste St. Louis South : 4318 Butler Hill Rd.
+1-888-897-9207
4318 Butler Hill Rd., St Louis, MO 63128 ~26.12 miles northeast of Desoto
  • 3 star property
From$90
Average 3.0 /5 Recent Reviews Call BookMore Details
Holiday Inn Express & Suites St. Louis South - I-55, an IHG Hotel - St. Louis
+1-888-311-4278
4250 Midamerica Ln, St. Louis, MO 63129 ~26.15 miles northeast of Desoto
  • Mid-scale Suburban hotel
  • Hotel has an eco-friendly policy Learn more
From$80
Average 3.0 /5 Review Score Call BookMore Details
Quality Inn Near Six Flags St. Louis in Pacific
+1-888-469-4795
1400 West Osage St., Pacific, MO 63069 ~26.20 miles northwest of Desoto
  • Midscale Rural property
  • Free comp. breakfast
From$80
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Hampton Inn & Suites St. Louis/South I-55 in St. Louis
+1-888-734-9421
4200 Midamerica Ln, St. Louis, MO 63129 ~26.21 miles northeast of Desoto
  • Three Star Suburban property
  • Check-in time: 3:00pm
From$80
Very Good 4.0 /5 Read Reviews Call BookMore Details
Comfort Inn Near Six Flags St. Louis in Pacific
+1-888-841-5292
1320 Thornton St., Pacific, MO 63069 Website ~26.31 miles northwest of Desoto
  • Mid-scale Highway hotel
  • Free breakfast
From$88
Average 3.0 /5 Latest Reviews Call BookMore Details
Holiday Inn St. Louis West Six Flags, an IHG Hotel : 4901 Six Flags Rd.
+1-888-455-5160
4901 Six Flags Rd., Eureka, MO 63025 ~26.44 miles north of Desoto
  • Mid-scale Suburban property
  • 179 sleeping rooms in hotel
From$129
Average 3.0 /5 Latest Reviews Call BookMore Details
Super 8 by Wyndham Waterloo in Waterloo
+1-888-965-8297
112 Warren Dr., Waterloo, IL 62298 ~26.69 miles northeast of Desoto
  • Cheap Rural hotel
  • Free comp. breakfast
From$60
Average 3.5 /5 Read Reviews Call BookMore Details
Super 8 by Wyndham St. Clair MO in Saint Clair
+1-888-906-6358
1010 South Outer Rd., Saint Clair, MO 63077 ~27.54 miles northwest of Desoto
  • Economy Highway property
  • 3 floors in property
From$60
Average 3.0 /5 Hotel Reviews Call BookMore Details
Pinemark Inn & Suites
+1-888-749-6785
866 South Outer Rd., St. Clair, MO 63077 ~27.61 miles northwest of Desoto
  • 2-star Highway hotel
  • Free complimentary breakfast
From$61
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Drury Inn & Suites St. Louis Southwest - St. Louis
+1-888-878-9982
5 Lambert Drury Place (I 44 & 141), St. Louis, MO 63088 ~27.70 miles north of Desoto
  • Midscale Suburban hotel
  • Hotel has 2 meeting rooms
From$84
Very Good 4.5 /5 Hotel Reviews Call BookMore Details
Hampton Inn by Hilton : 165 Admiral Trost Dr.
+1-888-389-4485
165 Admiral Trost Dr., Columbia, IL 62236 ~27.78 miles northeast of Desoto
  • Midscale Suburban hotel
  • 2 meeting rooms in hotel
From$79
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Holiday Inn Express St. Louis West Fenton
+1-888-389-4121
1848 Bowles Ave., Fenton, MO 63026 ~28.01 miles north of Desoto
  • 3 star Suburban hotel
  • Fitness + Health Center
From$80
Very Good 4.0 /5 Review Score Call BookMore Details
Motel 6 Fenton Mo
+1-888-675-2083
1860 Bowles Ave., Fenton, MO 63026 ~28.03 miles north of Desoto
  • Two star property
From$60
Average 3.0 /5 Recent Reviews Call BookMore Details
Pear Tree Inn St. Louis Fenton
+1-800-716-8490
1100 South Highway Dr., Fenton, MO 63026 ~28.25 miles north of Desoto
  • 2 star Suburban property
  • Check-in time: 3:00 PM
From$75
Average 3.5 /5 Recent Reviews Call BookMore Details
Drury Inn & Suites St. Louis Fenton - Fenton
+1-800-805-5223
1088 South Highway Dr., Fenton, MO 63026 ~28.26 miles north of Desoto
  • Mid-scale Suburban property
  • Fitness center on property
From$94
Very Good 4.0 /5 Review Score Call BookMore Details
Extended Stay America Suites St. Louis Fenton
+1-888-965-1860
1662 Fenton Business Park Court, Fenton, MO 63026 ~28.29 miles north of Desoto
  • Affordable Suburban property
  • 94 suites in property
From$80
Average 3.0 /5 Latest Reviews Call BookMore Details
Americas Best Value Inn St. Louis South : 6602 South Lindbergh Blvd.
+1-888-788-5576
6602 South Lindbergh Blvd., St. Louis, MO 63123 ~28.30 miles northeast of Desoto
  • Two-star Suburban hotel
  • Check-in time: 3:00 PM
Super 8 by Wyndham Fenton/St. Louis Area : 650 South Highway Dr.
+1-888-897-9207
650 South Highway Dr., Fenton, MO 63026 ~28.38 miles north of Desoto
  • Inexpensive property
Microtel Inn & Suites by Wyndham Sainte Genevieve
+1-888-311-4278
21958 Highway 32, Sainte Genevieve, MO 63670 ~29.61 miles east of Desoto
  • Two-star Highway property
  • Free complimentary breakfast
From$75
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Days Inn by Wyndham St. Louis Lindbergh Boulevard
+1-888-469-4795
3660 South Lindbergh Blvd., St Louis, MO 63127 ~29.65 miles north of Desoto
  • Three Star Suburban hotel
  • Free complimentary breakfast
From$69
Average 3.0 /5 Hotel Reviews Call BookMore Details
Holiday Inn St. Louis Sw Route 66 An Ihg Hotel
+1-888-734-9421
10709 Watson Rd., St. Louis, MO 63127 ~29.82 miles north of Desoto
  • Midscale Suburban property
  • 12 suites in property
From$79
Average 3.0 /5 Hotel Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham
+1-888-841-5292
1580 South Kirkwood Rd., Saint Louis, MO 63127 ~29.89 miles north of Desoto
  • 3 star Suburban property
  • Hotel has 84 rooms
From$100
Average 3.0 /5 Read Reviews Call BookMore Details
Best Western St. Louis-Kirkwood Route 66
+1-888-455-5160
1200 South Kirkwood Rd., Saint Louis, MO 63122 ~30.33 miles north of Desoto
  • 3 star Suburban property
  • Fitness + Health Center
From$70
Very Good 4.0 /5 Guest Reviews Call BookMore Details
The Wildwood Hotel : 2801 Fountain Place
+1-888-965-8297
2801 Fountain Place, Wildwood, MO 63040 ~30.80 miles north of Desoto
  • Expensive Suburban hotel
  • Check in: 04:00 PM
From$100
Very Good 4.0 /5 Review Score Call BookMore Details
Super 8 by Wyndham Union
+1-888-906-6358
1015 East Main St., Union, MO 63084 ~31.93 miles northwest of Desoto
  • Two-star Rural property
  • Free breakfast available
From$67
Average 3.0 /5 Recent Reviews Call BookMore Details
Courtyard by Marriott St. Louis West County : 12815a Daylight Dr.
+1-888-749-6785
12815a Daylight Dr., Town And Country, MO 63131 Website ~32.74 miles north of Desoto
  • Three Star Suburban property
  • Hotel has 4 floors
From$79
Very Good 4.0 /5 Read Reviews Call BookMore Details
Residence Inn by Marriott St. Louis West County - Town And Country
+1-888-878-9982
12815 Daylight Dr., Town And Country, MO 63131 Website ~32.74 miles north of Desoto
  • 3-star Suburban property
  • Check in time: 3pm
From$40
Very Good 4.0 /5 Read Reviews Call BookMore Details

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Graph: Upcoming 20 Days of Desoto Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Desoto, MO discounts available. The chart reflects the cheapest Desoto hotel for each day and each star rating category.

FAQs about hotels in Desoto

What are the top reviewed hotels in Desoto?

Drury Inn & Suites St. Louis Arnold, Holiday Inn Club Vac Timber Creek and Drury Inn & Suites St. Louis Southwest are the best rated hotels based on customer reviews in the last 365 days.

What are the most high-end hotels in Desoto?

The Wildwood Hotel, Holiday Inn Club Vac Timber Creek and Comfort Inn Festus - St Louis South are the top 3 luxury hotels near Desoto city center.

What hotels are closest to the city center of Desoto?

Holiday Inn Club Vac Timber Creek, Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS, an I, and Comfort Inn Festus - St Louis South are the properties closest to Desoto city center.

What are the most popular independent hotels in Desoto?

Pinemark Inn & Suites, The Wildwood Hotel and America's Best Inn Eureka are the best rated independent hotels (not part of a big brand).

What are the most popular Marriott hotels in Desoto?

Courtyard by Marriott St. Louis West County, Residence Inn by Marriott St. Louis West County and Fairfield Inn N Ste St. Louis South are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the most popular Choice Hotels branded hotels in Desoto?

Comfort Inn Festus - St Louis South, Woodspring Suites St. Louis Arnold and Quality Inn Near Six Flags St. Louis are the best rated Choice Hotels branded hotels (based on HotelPlanner reviews score).

What are the most popular Best Western hotels in Desoto?

Crown Pointe Lodge, BW Signature Collection, Best Western St. Louis-Kirkwood Route 66 and Best Western St. Louis Inn are the best rated Best Western branded hotels (based on user reviews score).

What are the most popular IHG hotels in Desoto?

Holiday Inn Club Vac Timber Creek, Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS, an I and Holiday Inn Express & Suites Farmington, an IHG Hotel are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

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