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Greenville Illinois Hotels & Motels

Find hotels in Greenville using the list and search tools below. Find cheap and discounted hotel/motel rates in or nearby Greenville, IL for your upcoming personal or group travel. Discover the most popular Greenville, Illinois hotel and motel rooms. Browse the Greenville area hotels to find the perfect lodging! Please use the provided map of the Greenville hotels.

The Greenville center is around the area of Edward A Utlaut Hospital and 17 miles west of Fayette County Museum.

Greenville Hotels, Motels & Accommodations

Super 8 by Wyndham Greenville - Greenville 1700 State Route 127, Greenville, IL 62246
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  • 2-star Rural hotel
  • Free comp. breakfast
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From$60
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SureStay by Best Western Greenville - Greenville 1731 South State Route 127, Greenville, IL 62246
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  • 2-star Highway property
  • Free breakfast available
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From$41
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Comfort Inn & Suites Greenville I-70 : 2265 South State Route 127 2265 South State Route 127, Greenville, IL 62246 Website
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  • Inexpensive Rural hotel
  • 16 suites in hotel
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From$53
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Holiday Inn Express & Suites Vandalia Il 21 Mattes Ave., Vandalia, IL 62471
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~15.52 miles east of Greenville
  • Midscale Highway property
  • 70 sleeping rooms in hotel
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From$80
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Ramada by Wyndham Vandalia 2707 Veterans Ave., Vandalia, IL 62471
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~15.77 miles east of Greenville
  • Two-star hotel
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From$60
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Americas Best Value Inn Vandalia 1500 North 6th St., Vandalia, IL 62471
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~17.45 miles east of Greenville
  • Two star Lake hotel
  • 44 sleeping rooms in hotel
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From$50
Average 3.0 /5 Recent Reviews Call BookMore Details
Quality Inn & Suites Vandalia near I-70 and Hwy 51 1920 North Kennedy Blvd., Vandalia, IL 62471 Website
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~17.57 miles east of Greenville
  • Two-star Highway property
  • Hotel has 79 rooms
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From$60
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Quality Inn & Suites Vandalia near I-70 and Hwy 51 1920 Kennedy Blvd., Vandalia, IL 62471
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~17.59 miles east of Greenville
  • Two-star Rural property
  • Check in: 2:00 p.m.
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From$57
Very Good 4.5 /5 Latest Reviews Call BookMore Details
Seasons Inn & Suites Highland : 20 Central Blvd. 20 Central Blvd., Highland, IL 62249
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~17.74 miles southwest of Greenville
  • Cheap property
  • Check in: 3:00 PM
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From$65
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Mariner's Village Resort & Inn in Carlyle 1 Resort Dr., Carlyle, IL 62231
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~18.34 miles south of Greenville
  • Cheap Lake property
  • Hotel has 65 rooms
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From$59
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Centerstone Inn & Suites 1371 William Rd., Carlyle, IL 62231
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~18.46 miles south of Greenville
  • Economical hotel
  • 41 rooms in property
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From$60
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Super 8 by Wyndham Staunton 1527 Herman Rd., Staunton, IL 62088
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~21.09 miles west of Greenville
  • Inexpensive hotel
  • Free breakfast
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From$50
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Innkeeper Motel 401 East State St., Hamel, IL 62046
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~23.07 miles west of Greenville
  • Three Star Lake hotel
  • Check-in: 2:00 PM
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From$80
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Americas Best Value Inn Litchfield 224 North Ohren Lane, Litchfield, IL 62056
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~24.10 miles northwest of Greenville
  • Low-priced property
  • 2 floors in hotel
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From$60
Poor 2.0 /5 Guest Reviews Call BookMore Details
Motel 6 Litchfield, IL 211 Ohren Ln, Litchfield, IL 62056
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~24.16 miles northwest of Greenville
  • Low-priced Highway hotel
  • Check in time: 11:00 AM
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From$60
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Baymont by Wyndham Litchfield 1405 West Hudson Dr., Litchfield, IL 62056
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~24.16 miles northwest of Greenville
  • Low priced Highway hotel
  • Free complimentary breakfast
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From$60
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Quality Inn Litchfield Route 66 in Litchfield 1010 East Columbian Blvd. North, Litchfield, IL 62056 Website
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~24.37 miles northwest of Greenville
  • Low Cost Downtown hotel
  • Gym is available on property
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From$70
Very Good 4.5 /5 Review Score Call BookMore Details
Hampton Inn Litchfield in Litchfield 11 Thunderbird Cir, Litchfield, IL 62056
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~24.48 miles northwest of Greenville
  • Mid-scale Highway property
  • Check in time: 3:00pm
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From$80
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Holiday Inn Express & Suites Litchfield West by IHG 4 Thunderbird Circle, Litchfield, IL 62056
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~24.49 miles northwest of Greenville
  • Mid-scale Rural hotel
  • Gym is available on property
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From$79
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Best Western Plus Centralia Hotel & Suites in Centralia 8145 Jolliff Bridge Rd., Centralia, IL 62801
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~28.09 miles southeast of Greenville
  • Affordable property
  • Check in time: 03:00
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From$78
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Americas Best Value Inn in Centralia 200 East Noleman, Centralia, IL 62801
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~29.09 miles southeast of Greenville
  • Two star property
  • 4 floors in property
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From$60
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Motel 6 Troy Il in Troy 909 Edwardsville Rd., Troy, IL 62294
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~29.31 miles west of Greenville
  • Two star property
  • 2 floors in property
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From$50
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Quality Inn & Suites Salem near I-57 in Salem 1800 West Main St., Salem, IL 62881 Website
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~29.38 miles southeast of Greenville
  • Cheap Rural hotel
  • Free comp. breakfast
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From$69
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Best Western Troy Hotel : 2020 Formosa Rd. 2020 Formosa Rd., Troy, IL 62294
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~29.44 miles west of Greenville
  • 3 star Rural hotel
  • Comp. Breakfast
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From$60
Average 3.5 /5 Recent Reviews Call BookMore Details
Holiday Inn Express Troy by IHG : 2011 Formosa Rd. 2011 Formosa Rd., Troy, IL 62294
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~29.51 miles west of Greenville
  • Midscale Highway hotel
  • Check in time: 3:00 PM
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From$84
Very Good 4.5 /5 Latest Reviews Call BookMore Details
Red Roof Inn St Louis - Troy, IL in Troy 2030 Formosa Rd., Troy, IL 62294
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~29.55 miles west of Greenville
  • Low-priced hotel
  • Check in time: 3:00pm
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From$53
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Days Inn by Wyndham Salem, Illinois - Salem 1812 West Main St., Salem, IL 62881
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~29.55 miles southeast of Greenville
  • Two-star property
  • Hotel has 2 floors
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From$47
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Super 8 by Wyndham Troy IL/St. Louis Area 910 Edwardsville Rd., Troy, IL 62294
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~29.60 miles west of Greenville
  • Economical Highway hotel
  • 61 rooms in property
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From$63
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Super 8 by Wyndham Salem : 118 Woods Ln 118 Woods Ln, Salem, IL 62881
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~29.63 miles southeast of Greenville
  • Cheap Highway hotel
  • 58 rooms in property
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From$60
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Magnuson Grand Hotel And Conference Center : 19067 West Frontage Rd. 19067 West Frontage Rd., Raymond, IL 62560
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~29.70 miles northwest of Greenville
  • Affordable Rural hotel
  • Gym / Fitness Center Available
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From$49
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Holiday Inn Express & Suites Salem by IHG : 102 Holiday Lane 102 Holiday Lane, Salem, IL 62881
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~29.89 miles southeast of Greenville
  • Affordable Highway hotel
  • Gym / Fitness Center Available
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From$87
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Holiday Inn Express & Suites Edwardsville by IHG 1000 Plummer Dr., Edwardsville, IL 62025
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~31.59 miles west of Greenville
  • 3 star Suburban property
  • 2 meeting rooms in hotel
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From$94
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Country Hearth Inn & Suites Edwardsville St. Louis in Edwardsville 1013 Plummer Dr., Edwardsville, IL 62025
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~31.66 miles west of Greenville
  • Affordable Rural property
  • Free complimentary breakfast
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From$67
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Towneplace Suites by Marriott St. Louis Edwardsville Il 6101 Center Grove Rd., Edwardsville, IL 62025
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~31.67 miles west of Greenville
  • 3-star Suburban hotel
  • Fitness center on property
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From$90
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Best Western Plus MidAmerica Hotel 9730 Hayden Dr., Mascoutah, IL 62258
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~32.05 miles southwest of Greenville
  • Affordable Suburban hotel
  • Check in: 3:00PM
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From$69
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Super 8 by Wyndham Okawville 812 North Henhouse Rd., Okawville, IL 62271
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~32.28 miles south of Greenville
  • Two-star Rural hotel
  • Check-in: 2pm
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From$64
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Super 8 by Wyndham Okawville 812 North Hen House Rd., Okawville, IL 62271
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~32.28 miles south of Greenville
  • Economical hotel
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From$60
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Super 8 by Wyndham O'fallon - Ofallon 1100 Eastgate Dr., Ofallon, IL 62269
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~33.41 miles southwest of Greenville
  • 2 star Suburban property
  • Hotel has an eco-friendly policy See more
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From$40
Average 3.0 /5 Review Score Call BookMore Details
Comfort Inn Edwardsville - St. Louis in Edwardsville 3080 South State Rte 157, Edwardsville, IL 62025 Website
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~33.44 miles west of Greenville
  • 2 star Highway property
  • 4 floors in property
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From$60
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Hampton Inn & Suites St. Louis Edwardsville - Glen Carbon 5723 Heritage Crossing Dr., Glen Carbon, IL 62034
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~33.74 miles west of Greenville
  • 3-star Suburban property
  • Access to gym on-site
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From$99
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Best Western U. S. Inn 11640 State Route 127, Nashville, IL 62263
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~35.22 miles south of Greenville
  • Midscale Highway property
  • 48 rooms in property
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From$62
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Sleep Inn O Fallon Il 140 Venita Dr., O'fallon, IL 62269
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~35.35 miles southwest of Greenville
  • Affordable Suburban hotel
  • 71 sleeping rooms in hotel
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From$80
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Holiday Inn Express & Suites O'fallon / Shiloh An Ihg Hotel 3396 Green Mount Crossing, Shiloh, IL 62269
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~35.48 miles southwest of Greenville
  • Midscale Highway hotel
  • Gym is available on property
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From$99
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Comfort Inn & Suites Ofallon St. Louis Area 116 Regency Park, O'fallon, IL 62269
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~35.51 miles southwest of Greenville
  • Cheap Suburban property
  • 19 suites in property
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From$60
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Hampton Inn O'fallon Il 430 Regency Park, O'fallon, IL 62269
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~35.57 miles southwest of Greenville
  • Mid-scale Suburban hotel
  • 4 floors in property
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From$80
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La Quinta Inn & Suites by Wyndham O'fallon Il St. Louis in O'fallon 136 Regency Park, O'fallon, IL 62269
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~35.59 miles southwest of Greenville
  • Cheap Suburban property
  • 2 floors in property
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From$60
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Hilton Garden Inn St. Louis Shiloh / O'fallon Il : 360 Regency Park 360 Regency Park, O'fallon, IL 62269
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~35.65 miles southwest of Greenville
  • Affordable Suburban hotel
  • 3 conference rooms in property
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From$80
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Extended Stay America Select Suites - St. Louis - O' Fallon, IL : 154 Regency Park 154 Regency Park, O'fallon, IL 62269
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~35.68 miles southwest of Greenville
  • Cheap Highway property
  • 89 rooms in hotel
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From$39
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Welcome Suites 148 Regency Park, O'fallon, IL 62269
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~35.68 miles southwest of Greenville
  • Two-star Suburban hotel
  • Gym / Fitness Center Available
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From$40
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Towneplace Place Suites by Marriott St. Louis O Fallon Illinois 445 Regency Park Dr., Ofallon, IL 62269
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~35.68 miles southwest of Greenville
  • Midscale property
  • Hotel has 89 suites
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From$90
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Next: See My Greenville Hotels with Pricing

Graph: Upcoming 20 Days of Greenville Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Greenville, IL discounts available. The chart reflects the cheapest Greenville hotel for each day and each star rating category.

FAQs about hotels in Greenville

What are the top reviewed hotels in Greenville?

Holiday Inn Express & Suites Salem by IHG, Quality Inn & Suites Vandalia near I-70 and Hwy 51 and Quality Inn Litchfield Route 66 are the best rated hotels based on customer reviews in the last 365 days.

What are the upper-end hotels in Greenville?

Holiday Inn Express & Suites Vandalia Il, Innkeeper Motel and Hampton Inn Litchfield are the top 3 luxury hotels near Greenville city center.

What hotels are closest to the city center of Greenville?

Super 8 by Wyndham Greenville, SureStay by Best Western Greenville, and Comfort Inn & Suites Greenville I-70 are the properties closest to Greenville city center.

What are the best independent hotels in Greenville?

Mariner's Village Resort & Inn, Magnuson Grand Hotel And Conference Center and Welcome Suites are the best rated independent hotels (not part of a big brand).

What are the most popular Marriott hotels in Greenville?

Towneplace Suites by Marriott St. Louis Edwardsville Il and Towneplace Place Suites by Marriott St. Louis O Fallon Illinois are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the most popular Choice Hotels branded hotels in Greenville?

Quality Inn & Suites Vandalia near I-70 and Hwy 51, Quality Inn Litchfield Route 66 and Comfort Inn & Suites Greenville I-70 are the best rated Choice Hotels branded hotels (based on HotelPlanner reviews score).

What are the most popular Best Western hotels in Greenville?

Best Western Plus Centralia Hotel & Suites, Best Western Plus MidAmerica Hotel and Best Western U. S. Inn are the best rated Best Western branded hotels (based on user reviews score).

What are the most popular IHG hotels in Greenville?

Holiday Inn Express & Suites Salem by IHG, Holiday Inn Express Troy by IHG and Holiday Inn Express & Suites Litchfield West by IHG are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

Verified reviews of the city of Greenville

Below are reviews of the city of Greenville, IL from an actual visitor's perspective.

"Quiet town"
Score 4.0 / 5

Quiet town and my Son plays Basketball for Greenville university.

Newton A., from 26-Feb-2026
"Great Diner!"
Score 4.0 / 5

Vicky's Cafe was awesome!! Very helpful and polite staff! Clean diner with great food!

Amy S., from 24-Aug-2025
"Dressed up Strip area."
Score 4.0 / 5

They have dressed up the hotel strip area since our last visit.

Phillip D., from 22-Jun-2025
"Quiet Area"
Score 5.0 / 5

Quietness compared to the big city.

Marien C., from 09-Jul-2024
"Proximity to Carlyle"
Score 4.0 / 5

I was visiting family in Carlyle and this is the best location to stay.

Robin S., from 09-Jul-2024
"Greenville has some excellent museums!"
Score 5.0 / 5

Greenville has some excellent museums!

Hh K., from 17-Sep-2023
"Great Aquarium"
Score 4.0 / 5

I went to the aquarium which I thought was great!

Augustino P., from 26-Jun-2023
"College Campus"
Score 4.0 / 5

Visited the college campus.

Kelly M., from 13-Mar-2023
"Loved It!"
Score 5.0 / 5

Loved it all!

Tom W., from 28-Dec-2022
The average traveler rating of the city of Greenville, IL shown above is 4.3 out of 5 based on 9 reviews
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