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Greenville Illinois Hotels & Motels

Find hotels in Greenville using the list and search tools below. Find cheap and discounted hotel/motel rates in or nearby Greenville, IL for your upcoming personal or group travel. Discover the most popular Greenville, Illinois hotel and motel rooms. Browse the Greenville area hotels to find the perfect lodging! Please use the provided map of the Greenville hotels.

The Greenville center is around the area of Edward A Utlaut Hospital and 17 miles west of Fayette County Museum.

Greenville Hotels/Accommodations

Super 8 by Wyndham Greenville 1700 State Route 127, Greenville, IL 62246
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  • Economy Rural property
  • Check-in: 12:00 PM
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From$72 total
Average 3.0 /5 Guest Reviews Call BookMore Details
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SureStay by Best Western Greenville 1731 South State Route 127, Greenville, IL 62246
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  • Low priced Highway property
  • 2 floors in property
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From$49 total
Average 3.0 /5 Recent Reviews Call BookMore Details
Comfort Inn & Suites Greenville I-70 in Greenville 2265 South State Route 127, Greenville, IL 62246 Website
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  • Cheap Rural hotel
  • 2 meeting rooms in property
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From$63 total
Very Good 4.0 /5 Read Reviews Call BookMore Details
Holiday Inn Express & Suites Vandalia Il 21 Mattes Ave., Vandalia, IL 62471
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~15.52 miles east of Greenville
  • 3 star Highway hotel
  • Hotel has 15 suites
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From$96 total
Average 3.0 /5 Recent Reviews Call BookMore Details
Ramada by Wyndham Vandalia - Vandalia 2707 Veterans Ave., Vandalia, IL 62471
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~15.77 miles east of Greenville
  • Two-star property
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From$72 total
Average 3.0 /5 Reviews Call BookMore Details
Americas Best Value Inn Vandalia : 1500 North 6th St. 1500 North 6th St., Vandalia, IL 62471
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~17.45 miles east of Greenville
  • Two star Lake hotel
  • Check in: 3.00
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From$60 total
Average 3.0 /5 Latest Reviews Call BookMore Details
Quality Inn & Suites Vandalia near I-70 and Hwy 51 1920 North Kennedy Blvd., Vandalia, IL 62471 Website
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~17.57 miles east of Greenville
  • Cheap Highway hotel
  • 8 suites in property
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From$72 total
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Quality Inn & Suites Vandalia near I-70 and Hwy 51 1920 Kennedy Blvd., Vandalia, IL 62471
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~17.59 miles east of Greenville
  • Low Cost Rural hotel
  • Hotel has a green policy See policy
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From$68 total
Very Good 4.5 /5 Review Score Call BookMore Details
Seasons Inn & Suites Highland 20 Central Blvd., Highland, IL 62249
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~17.74 miles southwest of Greenville
  • Low-priced property
  • Check in: 3:00 PM
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From$78 total
Average 3.0 /5 Reviews Call BookMore Details
Mariner's Village Resort & Inn 1 Resort Dr., Carlyle, IL 62231
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~18.34 miles south of Greenville
  • 2-star Lake hotel
  • Free comp. breakfast
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From$70 total
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Centerstone Inn & Suites 1371 William Rd., Carlyle, IL 62231
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~18.46 miles south of Greenville
  • Cheap property
  • 2 floors in hotel
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From$72 total
Average 3.0 /5 Review Score Call BookMore Details
Super 8 by Wyndham Staunton - Staunton 1527 Herman Rd., Staunton, IL 62088
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~21.09 miles west of Greenville
  • Inexpensive property
  • Hotel has 50 rooms
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From$60 total
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Innkeeper Motel : 401 East State St. 401 East State St., Hamel, IL 62046
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~23.07 miles west of Greenville
  • Mid-scale Lake hotel
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From$96 total
Average 3.0 /5 Read Reviews Call BookMore Details
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Americas Best Value Inn Litchfield - Litchfield 224 North Ohren Lane, Litchfield, IL 62056
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~24.10 miles northwest of Greenville
  • 2-star hotel
  • 2 floors in hotel
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From$72 total
Poor 2.0 /5 Review Score Call BookMore Details
Motel 6 Litchfield, IL in Litchfield 211 Ohren Ln, Litchfield, IL 62056
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~24.16 miles northwest of Greenville
  • Economical Highway hotel
  • Check-in time: 11:00 AM
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From$72 total
Average 3.0 /5 Hotel Reviews Call BookMore Details
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Baymont by Wyndham Litchfield : 1405 West Hudson Dr. 1405 West Hudson Dr., Litchfield, IL 62056
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~24.16 miles northwest of Greenville
  • Economy Highway hotel
  • 3 floors in hotel
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From$72 total
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Quality Inn Litchfield Route 66 1010 East Columbian Blvd. North, Litchfield, IL 62056 Website
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~24.37 miles northwest of Greenville
  • Two-star Downtown property
  • Check in: 3:00 PM
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From$84 total
Very Good 4.5 /5 Hotel Reviews Call BookMore Details
Hampton Inn Litchfield 11 Thunderbird Cir, Litchfield, IL 62056
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~24.48 miles northwest of Greenville
  • Midscale Highway property
  • 64 rooms in hotel
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From$96 total
Average 3.0 /5 Reviews Call BookMore Details
Holiday Inn Express & Suites Litchfield West by IHG in Litchfield 4 Thunderbird Circle, Litchfield, IL 62056
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~24.49 miles northwest of Greenville
  • Midscale Rural property
  • 79 rooms in property
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From$94 total
Very Good 4.0 /5 Reviews Call BookMore Details
Best Western Plus Centralia Hotel & Suites 8145 Jolliff Bridge Rd., Centralia, IL 62801
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~28.09 miles southeast of Greenville
  • Midscale hotel
  • 17 suites in hotel
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From$93 total
Very Good 4.0 /5 Review Score Call BookMore Details
Americas Best Value Inn in Centralia 200 East Noleman, Centralia, IL 62801
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~29.09 miles southeast of Greenville
  • 2 star property
  • Free complimentary breakfast
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From$72 total
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Motel 6 Troy Il : 909 Edwardsville Rd. 909 Edwardsville Rd., Troy, IL 62294
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~29.31 miles west of Greenville
  • Economical property
  • Hotel has 2 floors
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From$60 total
Average 3.0 /5 Review Score Call BookMore Details
Quality Inn & Suites Salem near I-57 1800 West Main St., Salem, IL 62881 Website
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~29.38 miles southeast of Greenville
  • Cheap Rural hotel
  • Comp. Breakfast
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From$82 total
Very Good 4.0 /5 Review Score Call BookMore Details
Best Western Troy Hotel 2020 Formosa Rd., Troy, IL 62294
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~29.44 miles west of Greenville
  • Midscale Rural hotel
  • Free breakfast
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From$72 total
Average 3.5 /5 Guest Reviews Call BookMore Details
Holiday Inn Express Troy by IHG : 2011 Formosa Rd. 2011 Formosa Rd., Troy, IL 62294
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~29.51 miles west of Greenville
  • Mid-scale Highway hotel
  • Hotel has 4 floors
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From$100 total
Very Good 4.5 /5 Review Score Call BookMore Details
Red Roof Inn St Louis - Troy, IL in Troy 2030 Formosa Rd., Troy, IL 62294
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~29.55 miles west of Greenville
  • Two-star property
  • Hotel has 8 suites
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From$63 total
Very Good 4.0 /5 Reviews Call BookMore Details
Days Inn by Wyndham Salem, Illinois : 1812 West Main St. 1812 West Main St., Salem, IL 62881
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~29.55 miles southeast of Greenville
  • Cheap hotel
  • Fitness / Gym is on-site
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From$56 total
Very Good 4.0 /5 Review Score Call BookMore Details
Super 8 by Wyndham Troy IL/St. Louis Area 910 Edwardsville Rd., Troy, IL 62294
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~29.60 miles west of Greenville
  • Inexpensive Highway property
  • Check-in time: 03:00 PM
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From$75 total
Average 3.0 /5 Reviews Call BookMore Details
Super 8 by Wyndham Salem 118 Woods Ln, Salem, IL 62881
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~29.63 miles southeast of Greenville
  • Cheap Highway property
  • 58 rooms in hotel
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From$72 total
Average 3.0 /5 Recent Reviews Call BookMore Details
Magnuson Grand Hotel And Conference Center 19067 West Frontage Rd., Raymond, IL 62560
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~29.70 miles northwest of Greenville
  • Affordable Rural hotel
  • 97 rooms in property
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From$58 total
Very Good 4.0 /5 Read Reviews Call BookMore Details
Holiday Inn Express & Suites Salem by IHG : 102 Holiday Lane 102 Holiday Lane, Salem, IL 62881
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~29.89 miles southeast of Greenville
  • Affordable Highway hotel
  • 86 sleeping rooms in hotel
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From$104 total
Excellent 5.0 /5 Guest Reviews Call BookMore Details
Holiday Inn Express & Suites Edwardsville by IHG in Edwardsville 1000 Plummer Dr., Edwardsville, IL 62025
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~31.59 miles west of Greenville
  • Three Star Suburban hotel
  • Hotel has 2 meeting rooms
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From$112 total
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Country Hearth Inn & Suites Edwardsville St. Louis in Edwardsville 1013 Plummer Dr., Edwardsville, IL 62025
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~31.66 miles west of Greenville
  • 3-star Rural property
  • Check in time: 15:00
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From$80 total
Very Good 4.0 /5 Reviews Call BookMore Details
TownePlace Suites by Marriott St. Louis Edwardsville, IL 6101 Center Grove Rd., Edwardsville, IL 62025
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~31.67 miles west of Greenville
  • 3-star Suburban property
  • 5 floors in hotel
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From$108 total
Very Good 4.0 /5 Read Reviews Call BookMore Details
Best Western Plus MidAmerica Hotel - Mascoutah 9730 Hayden Dr., Mascoutah, IL 62258
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~32.05 miles southwest of Greenville
  • Three Star Suburban hotel
  • Hotel has an eco-friendly policy See more
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From$82 total
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Super 8 by Wyndham Okawville - Okawville 812 North Henhouse Rd., Okawville, IL 62271
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~32.28 miles south of Greenville
  • Economy Rural hotel
  • 2 suites in hotel
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From$76 total
Average 3.0 /5 Guest Reviews Call BookMore Details
Super 8 by Wyndham Okawville 812 North Hen House Rd., Okawville, IL 62271
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~32.28 miles south of Greenville
  • Low-priced property
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From$72 total
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Super 8 by Wyndham O'fallon - Ofallon 1100 Eastgate Dr., Ofallon, IL 62269
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~33.41 miles southwest of Greenville
  • Economical Suburban property
  • 8 suites in property
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From$48 total
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Comfort Inn Edwardsville - St. Louis - Edwardsville 3080 South State Rte 157, Edwardsville, IL 62025
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~33.44 miles west of Greenville
  • Low-priced Highway hotel
  • 4 suites in property
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From$72 total
Average 3.0 /5 Guest Reviews Call BookMore Details
Comfort Inn Edwardsville : 3080 Il 157 3080 Il 157, Edwardsville, IL 62025
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~33.44 miles west of Greenville
  • 3 star Highway property
  • Fitness center on property
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From$96 total
Average 3.0 /5 Recent Reviews Call BookMore Details
Hampton Inn & Suites St. Louis Edwardsville : 5723 Heritage Crossing Dr. 5723 Heritage Crossing Dr., Glen Carbon, IL 62034
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~33.74 miles west of Greenville
  • Mid-scale Suburban hotel
  • 72 sleeping rooms in hotel
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From$118 total
Very Good 4.0 /5 Reviews Call BookMore Details
Best Western U. S. Inn : 11640 State Route 127 11640 State Route 127, Nashville, IL 62263
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~35.22 miles south of Greenville
  • Three Star Highway property
  • Free breakfast available
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From$73 total
Very Good 4.0 /5 Review Score Call BookMore Details
Sleep Inn O Fallon Il - O'fallon 140 Venita Dr., O'fallon, IL 62269
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~35.35 miles southwest of Greenville
  • Midscale Suburban property
  • Free complimentary breakfast
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From$96 total
Average 3.0 /5 Hotel Reviews Call BookMore Details
Holiday Inn Express & Suites O'fallon / Shiloh An Ihg Hotel : 3396 Green Mount Crossing 3396 Green Mount Crossing, Shiloh, IL 62269
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~35.48 miles southwest of Greenville
  • 3-star Highway property
  • Check-in time: 3:00
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From$118 total
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Comfort Inn & Suites Ofallon St. Louis Area 116 Regency Park, O'fallon, IL 62269
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~35.51 miles southwest of Greenville
  • Inexpensive Suburban hotel
  • Check in: 3:00 PM
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From$72 total
Average 3.0 /5 Read Reviews Call BookMore Details
Hampton Inn O'fallon Il 430 Regency Park, O'fallon, IL 62269
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~35.57 miles southwest of Greenville
  • Three Star Suburban hotel
  • Hotel has 100 rooms
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From$96 total
Very Good 4.0 /5 Latest Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham O'fallon Il St. Louis - O'fallon 136 Regency Park, O'fallon, IL 62269
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~35.59 miles southwest of Greenville
  • Cheap Suburban hotel
  • Check-in: 3:00 PM
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From$72 total
Average 3.0 /5 Latest Reviews Call BookMore Details
Hilton Garden Inn St. Louis Shiloh / O'fallon Il in O'fallon 360 Regency Park, O'fallon, IL 62269
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~35.65 miles southwest of Greenville
  • 3 star Suburban hotel
  • 3 meeting rooms in property
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From$96 total
Average 3.0 /5 Review Score Call BookMore Details
Extended Stay America Select Suites - St. Louis - O' Fallon, IL 154 Regency Park, O'fallon, IL 62269
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~35.68 miles southwest of Greenville
  • Cheap Highway property
  • 3 floors in property
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From$46 total
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Welcome Suites in O'fallon 148 Regency Park, O'fallon, IL 62269
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~35.68 miles southwest of Greenville
  • Cheap Suburban property
  • Access to gym on-site
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From$48 total
Very Good 4.0 /5 Reviews Call BookMore Details

Next: See My Greenville Hotels with Pricing

Graph: Upcoming 20 Days of Greenville Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Greenville, IL discounts available. The chart reflects the cheapest Greenville hotel for each day and each star rating category.

FAQs about hotels in Greenville

What are the top reviewed hotels in Greenville?

Holiday Inn Express & Suites Salem by IHG, Quality Inn & Suites Vandalia near I-70 and Hwy 51 and Quality Inn Litchfield Route 66 are the best rated hotels based on customer reviews in the last 365 days.

What are the upper-end hotels in Greenville?

Holiday Inn Express & Suites Vandalia Il, Innkeeper Motel and Hampton Inn Litchfield are the top 3 luxury hotels near Greenville city center.

What hotels are closest to the city center of Greenville?

Super 8 by Wyndham Greenville, SureStay by Best Western Greenville, and Comfort Inn & Suites Greenville I-70 are the properties closest to Greenville city center.

What are the best independent hotels in Greenville?

Mariner's Village Resort & Inn, Magnuson Grand Hotel And Conference Center and Welcome Suites are the best rated independent hotels (not part of a big brand).

What are the most popular Choice Hotels branded hotels in Greenville?

Quality Inn & Suites Vandalia near I-70 and Hwy 51, Quality Inn Litchfield Route 66 and Comfort Inn & Suites Greenville I-70 are the best rated Choice Hotels branded hotels (based on HotelPlanner reviews score).

What are the most popular Best Western hotels in Greenville?

Best Western Plus Centralia Hotel & Suites, Best Western Plus MidAmerica Hotel and Best Western U. S. Inn are the best rated Best Western branded hotels (based on user reviews score).

What are the most popular IHG hotels in Greenville?

Holiday Inn Express & Suites Salem by IHG, Holiday Inn Express Troy by IHG and Holiday Inn Express & Suites Litchfield West by IHG are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

Verified reviews of the city of Greenville

Below are reviews of the city of Greenville, IL from an actual visitor's perspective.

"Pizza slices at Casey's was very good"
Score 5.0 / 5

Akia S., from 12-Jul-2026
"Quiet town"
Score 4.0 / 5

Quiet town and my Son plays Basketball for Greenville university.

Newton A., from 26-Feb-2026
"Great Diner!"
Score 4.0 / 5

Vicky's Cafe was awesome!! Very helpful and polite staff! Clean diner with great food!

Amy S., from 24-Aug-2025
"Dressed up Strip area."
Score 4.0 / 5

They have dressed up the hotel strip area since our last visit.

Phillip D., from 22-Jun-2025
"Quiet Area"
Score 5.0 / 5

Quietness compared to the big city.

Marien C., from 09-Jul-2024
"Proximity to Carlyle"
Score 4.0 / 5

I was visiting family in Carlyle and this is the best location to stay.

Robin S., from 09-Jul-2024
"Greenville has some excellent museums!"
Score 5.0 / 5

Greenville has some excellent museums!

Hh K., from 17-Sep-2023
"Great Aquarium"
Score 4.0 / 5

I went to the aquarium which I thought was great!

Augustino P., from 26-Jun-2023
"College Campus"
Score 4.0 / 5

Visited the college campus.

Kelly M., from 13-Mar-2023
"Loved It!"
Score 5.0 / 5

Loved it all!

Tom W., from 28-Dec-2022
The average traveler rating of the city of Greenville, IL shown above is 4.4 out of 5 based on 10 reviews
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