Kirksville Missouri Accommodations

Find the perfect hotel in Kirksville using our hotel guide provided below. Search for cheap and discounted hotel and motel rates in or close to Kirksville, MO for your personal leisure or group travel. Discover the most favored Kirksville Missouri hotel/motel rooms. Review the Kirksville hotel list below to find the perfect lodging. We also have a map of the Kirksville hotels. Coordinating a group? Get Kirksville Group Hotel Deals

The Kirksville center point is approximately the area of Matthews Kirksville College and the area of Northeast Regional Medical Center.

Nestled in the corner of northeast Missouri, Kirksville is a university town that's home to a long list of historic places, cultural attractions, and outdoor destinations. Whether you're in town to tour one of the campuses or you want to explore the area's history and natural beauty, you're in for a pleasant surprise. Discover the best things to do and find the perfect place to stay in Kirksville. More from this guide...

Kirksville Hotels/Accommodations

Holiday Inn Express & Suites Kirksville - University Area by IHG 2523 South Franklin St., Kirksville, MO 63501 +1-888-389-4121
  • Three Star property
  • Free breakfast
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Excellent 9.2 /10 Read Reviews Call BookMore Details
Hampton Inn Kirksville 2604 North Baltimore Street, Kirksville, MO 63501 +1-888-675-2083
  • Three Star hotel
  • Free breakfast
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Excellent 9.2 /10 Hotel Reviews Call BookMore Details
Depot Inn and Suites 1245 North Brown St., La Plata, MO 63549 +1-800-716-8490 ~11.90 miles southeast of Kirksville
  • 3-star hotel
  • Pets are OK
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Excellent 9.8 /10 Recent Reviews Call BookMore Details
Baymont by Wyndham Kirksville University Area 2702 South Franklin, Kirksville, MO 63501 +1-800-805-5223
  • Midscale property
  • Check in time: 4:00 PM - midnight
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Average 7.6 /10 Hotel Reviews Call BookMore Details
Quality Inn Kirksville 2209 North Baltimore Street, Kirksville, MO 63501 +1-888-965-1860
  • Three Star hotel
  • Gym / Fitness Center Available
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Average 7.6 /10 Guest Reviews Call BookMore Details
Cobblestone Inn & Suites - Bloomfield 509 South Washington St, Bloomfield, IA 52537 +1-888-788-5576 ~39.40 miles north of Kirksville
  • Three Star property
  • 2 floors in property
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Excellent 9.0 /10 Reviews Call BookMore Details
Super 8 by Wyndham Macon 203 East Briggs Dr, Macon, MO 63552 +1-888-897-9207 ~30.84 miles south of Kirksville
  • Two star Motel property
  • Free comp. breakfast
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Average 7.8 /10 Review Score Call BookMore Details
The Continental Hotel 217 North 13th Street, Centerville, IA 52544 +1-888-311-4278 ~40.43 miles north of Kirksville
  • Three Star hotel
  • Hotel has 28 rooms
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Excellent 9.4 /10 Latest Reviews Call BookMore Details
Travelier Motel 201 East Briggs Dr, Macon, MO 63552 +1-888-469-4795 ~30.89 miles south of Kirksville
  • Three Star hotel
  • Check-in time: 2:00 PM - 11:00 PM
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Average 7.6 /10 Read Reviews Call BookMore Details
Days Inn by Wyndham Kirksville 3805 South Baltimore St, Kirksville, MO 63501 +1-888-734-9421
  • Economy hotel
  • Check-in time: 3:00 PM - 11:00 PM
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Average 6.6 /10 Guest Reviews Call BookMore Details
Super 8 by Wyndham Kirksville-University Area 1101 Country Club Dr, Kirksville, MO 63501 +1-888-841-5292
  • Mid-scale property
  • 61 rooms in hotel
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Very Good 8.8 /10 Review Score Call BookMore Details
Best Western Brookfield 28622 Highway 11, Brookfield, MO 64628 +1-888-455-5160 ~38.97 miles southwest of Kirksville
  • Three Star hotel
  • 3 suites in property
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Excellent 9.0 /10 Guest Reviews Call BookMore Details
Hotel Marceline 101 West Ira Street, Marceline, MO 64658 +1-888-965-8297 ~37.12 miles southwest of Kirksville
  • Midscale hotel
  • Check in: 12:00 PM - anytime
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Very Good 8.6 /10 Guest Reviews Call BookMore Details
Thousand Hills 20431 Missouri 157, Kirksville, MO 63501 +1-888-906-6358
  • Cheap hotel
  • 14 rooms in property
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Excellent 9.2 /10 Hotel Reviews Call BookMore Details
Knights Inn Kirksville 2521 South Franklin Street, Kirksville, MO 63501 +1-888-749-6785
  • Inexpensive Motel property
  • Check in: 3:00 PM - 11:00 PM
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Average 7.2 /10 Review Score Call BookMore Details
Budget Host Village Inn 1304 South Baltimore, Kirksville, MO 63501 +1-888-878-9982
  • 2 star Motel property
  • Pet Friendly
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Average 6.2 /10 Hotel Reviews Call BookMore Details
Southfork Motel and Grill 905 South Washington Street, Bloomfield, IA 52537 +1-888-389-4485 ~39.06 miles north of Kirksville
  • Two-star Motel property
  • Check in: 2:00 PM - anytime
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Average 7.7 /10 Review Score Call BookMore Details
Super 8 by Wyndham Centerville 1021 North 18th Highway 5 N, Centerville, IA 52544 +1-888-389-4121 ~40.97 miles north of Kirksville
  • Inexpensive Motel property
  • Pets Allowed
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Average 7.6 /10 Recent Reviews Call BookMore Details
Comfort Inn & Suites Macon 1821 North Missouri St, Macon, MO 63552 +1-888-675-2083 ~30.53 miles south of Kirksville
  • Midscale property
  • Check-in time: 15:00:00
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Excellent 9.5 /10 Read Reviews Call BookMore Details
Martin House Motel 731 South Main St, Brookfield, MO 64628 +1-800-716-8490 ~38.54 miles southwest of Kirksville
  • Economical Motel property
  • Pets are OK
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Average 7.2 /10 Guest Reviews Call BookMore Details
Simple Rewards Inn Shelbina 711 North Highway 15, Shelbina, MO 63468 +1-800-805-5223 ~44.47 miles southeast of Kirksville
  • High end hotel
  • Check in: 2:00 PM - 5:00 AM
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Very Good 8.9 /10 Reviews Call BookMore Details
Americas Best Value Inn & Suites Macon at Sunset Dr 28933 Sunset Drive, Macon, MO 63552 +1-888-965-1860 ~30.92 miles south of Kirksville
  • Inexpensive Motel property
  • Free comp. breakfast
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Westbridge Inn & Suites 117 North 18th St, Centerville, IA 52544 +1-888-788-5576 ~40.31 miles north of Kirksville
  • Economical Motel property
  • Pets are Allowed
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Maple Street Inn 406 West Maple St. CentervilleIowa 52544, Centerville, 52544 +1-888-897-9207 ~40.40 miles northwest of Kirksville
  • Affordable property
  • Check-in: 15:00:00
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Motel 60 & Villa 117 North 18th St. IA, Centerville, Iowa 52544 +1-888-311-4278 ~40.31 miles north of Kirksville
  • Low-priced Motel hotel
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When is the best time to visit Kirksville, Missouri?

You're likely to enjoy Kirksville, Missouri, most if you plan your visit around one of the city's major annual events. Visit around Independence Day to experience the Red, White, and Blue Festival, which features an apple pie contest, a community bike ride, a parade, a pancake breakfast, and fireworks. In mid-July, enjoy the NEMO Fair, a weeklong event with livestock shows, agricultural exhibits, tractor pulls, pageants, and fair food. In late September, don't miss the Red Barn Arts & Crafts Festival, which features regional artists, live music, dance performances, and local food.

What are the top hotels in Kirksville, MO for group discounts?

Want to grab a great deal in the Kirksville area? Browse the best hotel discounts and group rates in town.

Senior travelers can get discounts at Americas Best Value Inn Shelbina. Its 20 guest rooms offer affordable room rates and basics like free Wi-Fi, but you'll also get plenty of extras when you stay here. Take advantage of the free breakfast each morning of your stay, and enjoy the outdoor pool during the summer months. Need to freshen up or catch up on work during your stay? Stop by the guest laundry facilities or use the hotel's guest computer.

AAA members can get low rates at Americas Best Value Inn & Suites Macon at Sunset Drive. This budget-friendly property has 46 guest rooms equipped with money-saving essentials like microwaves, mini fridges, and coffee makers. Watch some movies on the premium channels, use the free Wi-Fi to plan your route, and bring your pets along for your stay at this pet-friendly hotel. Traveling with a group? Take advantage of generous group discounts, which total an average of 11%.

Government employees can save at the Super 8 Macon. Whether you choose a queen or king room, you can look forward to in-room amenities like mini fridges, microwaves, desks, and free Wi-Fi. Wake up to a quick cup of coffee in the hotel lobby or help yourself to the free SuperStart breakfast buffet. Traveling with kids? This Super 8 welcomes kids under 18 to stay free with parents.

What are the best value options in Kirksville, MO?

Need to get as much value as possible from your stay in Kirksville? Take a look at the area's best midrange accommodations.

Whether you're planning to stay for a night or for a week, the Quality Inn in Kirksville has you covered. Choose from queen or king rooms, and get comfy with pillowtop mattresses, free Wi-Fi, and a long list of hotel features. Visit the business center to catch up on work, or hit the fitness center for a workout. Set your alarm to make sure you don't miss the complimentary breakfast buffet, which includes waffles, eggs, sausage, oatmeal, and fresh fruit.

Stay at the Hampton Inn by Hilton Kirksville, and you'll be in the center of the action. Stop by the business center to send some emails, or make your way to the fitness center for a cardio session. After a great night's sleep, help yourself to the free breakfast buffet, which includes hot options, or grab a free cup of coffee in the lobby. In a rush to get your day started? Pick up a complimentary On the Run breakfast bag so you can fuel up on the go.

Located a short drive away in Brookfield, Missouri, the Best Western Brookfield offers tons of value. Guest rooms include essentials like mini fridges, microwaves, and coffee makers, and some upgraded rooms include Jacuzzis, too. Log in to the free Wi-Fi to book excursions or map out your route, and start your day on a bright note with the hotel's free full breakfast. In the afternoon, cool down beside the outdoor pool or head out to explore the best of Kirksville.

Which attractions should you visit in Kirksville, MO?

Whether you love learning about the past or you'd rather explore the great outdoors, Kirksville has what you're looking for. Start your visit with a tour of the Adair County Historical Society, where you can see local artifacts and photographs in a 100-year-old building. Next, tour the Museum of Osteopathic Medicine on the campus of A.T. Still University. Here, you'll find photos, artifacts, and displays that tell the story of the osteopathic profession.

If you're a science buff or if you're looking for a unique activity, head to the Del and Norma Robison Planetarium. Many of the planetarium and laser shows are open to the public for a nominal fee.

If you want to get outside and explore Kirksville's natural beauty, head to Big Creek Conservation Area. This 1,000-acre preserve is packed with a variety of habitats, including forests, woodlands, and savannas, and visitors can go hiking, fishing, hunting, and bird-watching. Next door to the conservation area, Thousand Hills State Park is home to tranquil Forest Lake and welcomes visitors to hike, mountain bike, swim, fish, and boat. Choose from a handful of hiking trails, fish for bass or walleye, and spot over 200 species of birds.

Why wait to book your trip to Kirksville? Reserve your room and get a great deal on travel today.

Recent traveler reviews of Kirksville, MO

Below are reviews of the city of Kirksville, MO from an actual visitor's perspective.

"Plenty of places to eat"
Score 4.0 / 5

Denita E., from 30-Sep-2026
"My step daughter n grandkids"
Score 5.0 / 5

My step daughter n grandkids live here come to see them.

Denise A., from 04-Apr-2026
"Downtown"
Score 4.0 / 5

Downtown

Lisa R., from 30-Mar-2026
"Football game and gasoline prices"
Score 5.0 / 5

George A., from 09-Nov-2025
"Nice City"
Score 5.0 / 5

Love 1000 hills state park.

Garry L., from 07-Nov-2025
"Friends"
Score 4.0 / 5

Had a great visit with old friends and fun driving around seeing all the changes in town.

Sue L., from 11-Oct-2025
"It’s my hometown"
Score 5.0 / 5

Nathan S., from 11-Oct-2025
"Didn't get to see, but did eat at "Coltons*. Great place."
Score 5.0 / 5

Nancy M., from 14-Sep-2025
"Family"
Score 4.0 / 5

My kids

Martin M., from 05-Sep-2025
"Shopping and food were convenient."
Score 5.0 / 5

Stacy S., from 01-Sep-2025
"Great Location"
Score 5.0 / 5

Great town. Good food ... especially the Wooden Nickel.

Gregory O., from 23-Jul-2025
"The room was clean and comfortable. The staff was extremely friendly and helpful. "
Score 5.0 / 5

The room was clean and comfortable. The staff was extremely friendly and helpful. Enjoyed Wooden Nickel & hospitality of 1st Baptist Church hosting our statewide WMU Missouri Missions Celebration

Jean P., from 15-Apr-2025
"Great location"
Score 4.0 / 5

Lots of things to do

Jack S., from 18-Feb-2025
"The room was clean and comfortable."
Score 5.0 / 5

The room was clean and comfortable. Kirksville was great. Small college town, friendly people. Great bar & restaurant called the Duku Inn.

John C., from 14-Dec-2024
"Great small college town, bars and restaurants."
Score 5.0 / 5

Kirksville was great. Small college town, friendly people. Great bar and restaurant called the Dukum Inn.

John C., from 14-Dec-2024
"Love Kirksville & Truman"
Score 5.0 / 5

Love Kirksville. I'm a Truman alumni. Wife and I travel to Kirksville about every three years. Great memories.

Patrick W., from 16-Oct-2024
"Love Kirksville!"
Score 4.0 / 5

we loved Kirksville, we've stayed there in the past.

Kathleen M., from 13-Jul-2024
"Small college town with every store I needed for supplies!"
Score 5.0 / 5

Small college town with every store I needed for supplies!

Kim N., from 01-Jul-2024
"Great Small Town With Good Amenities"
Score 5.0 / 5

I think Kirksville has a great small town feel but with several activities and dining experiences for guests.

Samantha C., from 07-Jun-2024
"Lots of Food!"
Score 5.0 / 5

Has lots of food availability.

Todd R., from 04-Mar-2024
"Very Friendly"
Score 5.0 / 5

Everybody was very, very friendly

Jim W., from 04-Feb-2024
"Forest Lake"
Score 4.0 / 5

Forest Lake

Tim G., from 03-Oct-2023
"Good"
Score 5.0 / 5

Good

Ronnie A., from 22-Aug-2023
"Ideal Location"
Score 4.0 / 5

Located near several good shopping centers and near gas stations, ideal for travelers and vacationers.

Shawn B., from 12-Jun-2023
"Great Restaurants Near Hotel"
Score 4.0 / 5

Two great restaurants near hotel.

Mary P., from 20-Feb-2023
"Convenient Location"
Score 5.0 / 5

Close to shopping, gas and food locations.

Charles B., from 14-Feb-2023
"Very Good Restaurant off the Square called Wooden Nickel!"
Score 4.0 / 5

We ate at the Wooden Nickel restaurant, just off the square. Very good!

Robert E., from 10-Jan-2023
"Very Nice"
Score 5.0 / 5

Very nice with plenty of businesses.

Gene L., from 16-Dec-2022
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