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Hotels Near Mayo Clinic Florida

Accommodations close to Mayo Clinic are shown in the list below sorted in the order of their distance (closest first). Browse our hotels to find accommodations near Mayo Clinic (Mayo Clinic) for your leisure or corporate trips. Mayo Clinic is located at 4500 San Pablo Rd S. We show the best lodging close to Mayo Clinic so you can review the available Mayo Clinic lodging below and securely book your ideal hotel.

Lodging & Accommodations close to Mayo Clinic

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches in Jacksonville
+1-888-389-4121
14390 Mayo Blvd., Jacksonville, FL 32224 ~0.08 miles southwest of Mayo Clinic
~1 minute walk
  • 3 star Beach property
  • Hotel has 2 meeting rooms
From$50
Very Good 4.0 /5 Reviews Call BookMore Details
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The Inn at Mayo Clinic - Jacksonville
+1-888-675-2083
4420 Mary Brigh Dr., Jacksonville, FL 32224 ~0.24 miles north of Mayo Clinic
~4 minute walk
  • Three Star Beach property
  • Check in: 3:00 PM
From$99
Very Good 4.0 /5 Reviews Call BookMore Details
Hilton Jacksonville at Mayo Clinic : 4745 Transformation Wy
+1-800-716-8490
4745 Transformation Wy, Jacksonville, FL 32224 ~0.45 miles southwest of Mayo Clinic
~8 minute walk
  • 4-star property
  • Hotel has 252 rooms
From$169
Average 3.0 /5 Reviews Call BookMore Details
Residence Inn Jacksonville East - Jacksonville
+1-800-805-5223
4905 San Pablo Rd. South, Jacksonville, FL 32224 ~0.51 miles south of Mayo Clinic
~9 minute walk
  • Midscale property
  • Check in time: 15:00
From$90
Excellent 5.0 /5 Hotel Reviews Call BookMore Details
Enso in Jacksonville
+1-888-965-1860
3650 Enso Wy, Jacksonville, FL 32224 ~1.24 miles north of Mayo Clinic
~22 minute walk
  • Luxurious 5-star Beach property
  • Hotel has 4 floors
From$225
Average 3.0 /5 Hotel Reviews Call BookMore Details
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG in Jacksonville
+1-888-788-5576
4791 Windsor Commons Court Jacksonville Fl 3222, Jacksonville, FL 32224 ~1.71 miles west of Mayo Clinic
  • Affordable Golf Course property
  • Free breakfast available
From$97
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Towneplace Suites & Hampton Inn Beach Blvd. Jacksonville in Jacksonville
+1-888-897-9207
13741 Beach Blvd. Jacksonville Fl 32224, Jacksonville, FL 32224 ~2.13 miles northwest of Mayo Clinic
  • Three Star property
From$80
Average 3.0 /5 Recent Reviews Call BookMore Details
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic in Jacksonville
+1-888-311-4278
13733 Beach Blvd., Jacksonville, FL 32224 ~2.13 miles northwest of Mayo Clinic
  • Affordable Suburban hotel
  • Hotel has 19 suites
From$80
Average 3.0 /5 Latest Reviews Call BookMore Details
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area in Jacksonville Beach
+1-888-469-4795
1220 Marsh Landing Pkwy., Jacksonville Beach, FL 32250 ~2.43 miles east of Mayo Clinic
  • Affordable Beach hotel
  • Free breakfast
From$99
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Holiday Inn Express Jacksonville Beach by IHG in Jacksonville Beach
+1-888-734-9421
1101 Beach Blvd., Jacksonville Beach, FL 32250 ~2.84 miles northeast of Mayo Clinic
  • Affordable Beach hotel
  • 3 floors in hotel
From$80
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Four Points by Sheraton Jacksonville Beachfront
+1-888-841-5292
11 1st St. North, Jacksonville Beach, FL 32250 ~3.40 miles northeast of Mayo Clinic
  • Affordable Beach property
  • Hotel has an eco-friendly policy Read more
From$130
Very Good 4.0 /5 Review Score Call BookMore Details
Best Western Oceanfront
+1-888-455-5160
305 1st St. North, Jacksonville Beach, FL 32250 ~3.49 miles northeast of Mayo Clinic
  • Mid-scale Beach hotel
  • 3 floors in property
From$80
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Casa Marina Hotel - Jacksonville Beach
+1-888-965-8297
691 1st St. North, Jacksonville Beach, FL 32250 ~3.60 miles northeast of Mayo Clinic
  • Mid-scale Oceanfront property
  • 3 meeting rooms in property
From$110
Average 3.5 /5 Recent Reviews Call BookMore Details
Margaritaville Jacksonville : 715 1st St. North
+1-888-906-6358
715 1st St. North, Jacksonville, FL 32250 ~3.63 miles northeast of Mayo Clinic
  • High-end hotel
From$200
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Ponte Vedra Inn & Club : 200 Ponte Vedra Blvd.
+1-888-749-6785
200 Ponte Vedra Blvd., Ponte Vedra Beach, FL 32082 ~3.78 miles east of Mayo Clinic
  • Luxurious 5 Star Beach property
  • Check-in: 4:00 PM
From$179
Very Good 4.0 /5 Reviews Call BookMore Details
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Hampton Inn Jacksonville Beach / Oceanfront
+1-888-878-9982
1515 1st St. North, Jacksonville Beach, FL 32250 ~3.91 miles northeast of Mayo Clinic
  • Mid-scale Beach hotel
  • Fitness center on property
From$79
Very Good 4.5 /5 Recent Reviews Call BookMore Details
Fairfield Inn & Suites by Marriott Jacksonville Beach - Jacksonville Beach
+1-888-389-4485
1616 1st St. North, Jacksonville Beach, FL 32250 ~3.92 miles northeast of Mayo Clinic
  • Three Star Beach hotel
  • Hotel has 3 floors
From$129
Very Good 4.0 /5 Review Score Call BookMore Details
Courtyard by Marriott Jacksonville Beach Oceanfront
+1-888-389-4121
1617 1st St. North, Jacksonville Beach, FL 32250 ~3.93 miles northeast of Mayo Clinic
  • 3 star Beach property
  • Access to gym on-site
From$159
Very Good 4.5 /5 Hotel Reviews Call BookMore Details
Courtyard by Marriott Oceanfront Jacksonville Beach : 1617 North 1st St.
+1-888-675-2083
1617 North 1st St., Jacksonville Beach, FL 32250 ~3.94 miles northeast of Mayo Clinic
  • 3-star Beach property
  • 150 rooms in hotel
From$199
Very Good 4.5 /5 Reviews Call BookMore Details
Red Roof Inn PLUS+ Neptune Beach - Jacksonville Beach
+1-800-716-8490
1401 Atlantic Blvd., Neptune Beach, FL 32266 ~4.50 miles north of Mayo Clinic
  • Midscale Beach hotel
  • Complimentary breakfast is offered
From$53
Very Good 4.0 /5 Read Reviews Call BookMore Details
Holiday Inn Express & Suites Jacksonville Town Center : 10573 Brightman Blvd.
+1-800-805-5223
10573 Brightman Blvd., Jacksonville, FL 32246 ~4.96 miles west of Mayo Clinic
  • Mid-scale Downtown property
  • Free breakfast
From$89
Very Good 4.0 /5 Guest Reviews Call BookMore Details
The Lodge and Club at Ponte Vedra Beach
+1-888-965-1860
607 Ponte Vedra Blvd., Ponte Vedra Beach, FL 32082 ~4.96 miles southeast of Mayo Clinic
  • Luxury 5-star hotel
  • 66 rooms in hotel
From$250
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
One Ocean Resort and Spa
+1-888-788-5576
1 Ocean Blvd., Atlantic Beach, FL 32233 ~5.01 miles northeast of Mayo Clinic
  • Expensive Beach hotel
  • 9 meeting rooms in property
From$131
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass : 45 Tournament Players Club Blvd.
+1-888-897-9207
45 Tournament Players Club Blvd., Ponte Vedra Beach, FL 32082 ~5.10 miles southeast of Mayo Clinic
  • 3-star Resort hotel
  • Hotel has 2 meeting rooms
From$129
Very Good 4.5 /5 Reviews Call BookMore Details
Sawgrass Marriott Golf Resort & Spa - Ponte Vedra Beach
+1-888-311-4278
1000 Pga Tour Blvd., Ponte Vedra Beach, FL 32082 ~5.15 miles southeast of Mayo Clinic
  • Four star Beach hotel
  • Fitness center on property
From$129
Very Good 4.0 /5 Latest Reviews Call BookMore Details

Next: Show All Available Mayo Clinic Hotels with Pricing

Bar Chart: Upcoming 20 Days of Mayo Clinic Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Pablo Keys, FL discounts available. The chart reflects the cheapest Pablo Keys hotel for each day and each star rating category.

What are the best hotels near Mayo Clinic?

HotelDescriptionLink
1. Courtyard by Marriott Jacksonville at Mayo Clinic Campus The Courtyard by Marriott Jacksonville at Mayo Clinic Campus is a popular 3-Star hotel located approx. 0.1 miles southwest of Mayo Clinic and roughly a 1 minute stroll by foot. Recent hotel guests gave this hotel a verified guest score of 4/5. Get the latest price
2. Inn at Mayo Clinic The Inn at Mayo Clinic is a favored 3-Star hotel located ~0.2 mi. north of Mayo Clinic and approx. a 3 minute walk by foot. With a verified guest score of 4/5, this makes it one of the most desirable hotels nearby Mayo Clinic. Get the latest price
3. Residence Inn Jacksonville East The Residence Inn Jacksonville East is an in demand 3-Star hotel located approx. 0.5 miles south of Mayo Clinic and roughly a 9 minute stroll by foot. With a average guest review rating of 5/5, this makes it one of the most desirable lodging options close to Mayo Clinic. Get the latest price
4. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG The Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG is a popular 3 star hotel located approx. 1.7 miles west of Mayo Clinic and about a 3 min. drive. With a guest review score of 4 out of 5, this makes it one of the premium properties close to Mayo Clinic. Get the latest price
5. Hampton Inn Jacksonville The Hampton Inn Jacksonville is a popular 3 star hotel located approx. 2.4 miles east of Mayo Clinic and about a 4 min. drive. Recent guests gave this hotel an avg. guest review rating of 4 out of 5. Get the latest price

5 Best Hotels near Mayo Clinic

FAQs about hotels near Mayo Clinic

What are the most favored hotels near Mayo Clinic?

Residence Inn Jacksonville East, Hampton Inn Jacksonville Beach and Courtyard by Marriott Jacksonville Beach Oceanfront are the best rated hotels based on customer reviews in the last 365 days.

What are the most up-scale hotels near Mayo Clinic?

Enso, Ponte Vedra Inn & Club and The Lodge and Club at Ponte Vedra Beach are the top 3 luxury hotels near Mayo Clinic.

What hotels are closest to the area of Mayo Clinic?

Courtyard by Marriott Jacksonville at Mayo Clinic Campus, The Inn at Mayo Clinic, and Hilton Jacksonville at Mayo Clinic are the properties closest to Mayo Clinic.

What are the most popular independent hotels near Mayo Clinic?

The Inn at Mayo Clinic, Margaritaville Jacksonville and Ponte Vedra Inn & Club are the best rated independent hotels (not part of a big brand).

What are the best Marriott hotels near Mayo Clinic?

Residence Inn Jacksonville East, Courtyard by Marriott Jacksonville Beach Oceanfront and Courtyard by Marriott Oceanfront Jacksonville Beach are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the best IHG hotels near Mayo Clinic?

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG, Holiday Inn Express Jacksonville Beach by IHG and Holiday Inn Express & Suites Jacksonville Town Center are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

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