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Hotels Near Mayo Clinic Florida

Accommodations close to Mayo Clinic are shown in the list below sorted in the order of their distance (closest first). Browse our hotels to find accommodations near Mayo Clinic (Mayo Clinic) for your leisure or corporate trips. Mayo Clinic is located at 4500 San Pablo Rd S. We show the best lodging close to Mayo Clinic so you can review the available Mayo Clinic lodging below and securely book your ideal hotel.

Lodging & Accommodations close to Mayo Clinic

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches - Jacksonville
+1-888-389-4121
14390 Mayo Blvd., Jacksonville, FL 32224 ~0.08 miles southwest of Mayo Clinic
~1 minute walk
  • Affordable Beach property
  • 3 floors in hotel
From$50
Very Good 4.0 /5 Guest Reviews Call BookMore Details
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The Inn at Mayo Clinic - Jacksonville
+1-888-675-2083
4420 Mary Brigh Dr., Jacksonville, FL 32224 ~0.24 miles north of Mayo Clinic
~4 minute walk
  • Three Star Beach property
  • Hotel has 3 floors
From$99
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Residence Inn Jacksonville East in Jacksonville
+1-800-716-8490
4905 San Pablo Rd. South, Jacksonville, FL 32224 ~0.51 miles south of Mayo Clinic
~9 minute walk
  • Three Star property
From$90
Excellent 5.0 /5 Hotel Reviews Call BookMore Details
Enso
+1-800-805-5223
3650 Enso Wy, Jacksonville, FL 32224 ~1.24 miles north of Mayo Clinic
~22 minute walk
  • Luxury 5-star Beach property
  • 4 suites in hotel
From$225
Average 3.0 /5 Recent Reviews Call BookMore Details
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area, an IH - Jacksonville
+1-888-965-1860
4791 Windsor Commons Court Jacksonville Fl 3222, Jacksonville, FL 32224 ~1.71 miles west of Mayo Clinic
  • Mid-scale Golf Course hotel
  • Hotel has 104 rooms
From$97
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Towneplace Suites & Hampton Inn Beach Blvd. Jacksonville in Jacksonville
+1-888-788-5576
13741 Beach Blvd. Jacksonville Fl 32224, Jacksonville, FL 32224 ~2.13 miles northwest of Mayo Clinic
  • Mid-scale property
From$80
Average 3.0 /5 Review Score Call BookMore Details
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic : 13733 Beach Blvd.
+1-888-897-9207
13733 Beach Blvd., Jacksonville, FL 32224 ~2.13 miles northwest of Mayo Clinic
  • Midscale Suburban hotel
  • Comp. Breakfast
From$80
Average 3.0 /5 Read Reviews Call BookMore Details
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area : 1220 Marsh Landing Pkwy.
+1-888-311-4278
1220 Marsh Landing Pkwy., Jacksonville Beach, FL 32250 ~2.43 miles east of Mayo Clinic
  • Midscale Beach property
  • Fitness center on property
From$99
Very Good 4.0 /5 Review Score Call BookMore Details
Holiday Inn Express Jacksonville Beach, an IHG Hotel in Jacksonville Beach
+1-888-469-4795
1101 Beach Blvd., Jacksonville Beach, FL 32250 ~2.84 miles northeast of Mayo Clinic
  • 3-star Beach hotel
  • Fitness center on property
From$80
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Four Points by Sheraton Jacksonville Beachfront
+1-888-734-9421
11 1st St. North, Jacksonville Beach, FL 32250 ~3.40 miles northeast of Mayo Clinic
  • Midscale Beach property
  • 72 suites in property
From$130
Very Good 4.0 /5 Read Reviews Call BookMore Details
Best Western Oceanfront
+1-888-841-5292
305 1st St. North, Jacksonville Beach, FL 32250 ~3.49 miles northeast of Mayo Clinic
  • Affordable Beach property
  • Check-in: 03:00
From$69
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Casa Marina Hotel
+1-888-455-5160
691 1st St. North, Jacksonville Beach, FL 32250 ~3.60 miles northeast of Mayo Clinic
  • 3-star Oceanfront property
  • 23 rooms in hotel
From$110
Average 3.5 /5 Latest Reviews Call BookMore Details
Margaritaville Jacksonville in Jacksonville
+1-888-965-8297
715 1st St. North, Jacksonville, FL 32250 ~3.63 miles northeast of Mayo Clinic
  • High-end hotel
  • 172 sleeping rooms in hotel
From$200
Very Good 4.0 /5 Read Reviews Call BookMore Details
Ponte Vedra Beach Resorts : 200 Ponte Vedra Blvd.
+1-888-906-6358
200 Ponte Vedra Blvd., Ponte Vedra Beach, FL 32082 ~3.78 miles east of Mayo Clinic
  • Luxury 5 star Beach hotel
  • Fitness center on property
From$179
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Hampton Inn Jacksonville Beach/Oceanfront
+1-888-749-6785
1515 1st St. North, Jacksonville Beach, FL 32250 ~3.92 miles northeast of Mayo Clinic
  • 3 star Oceanfront property
  • 7 floors in property
From$150
Average 3.0 /5 Recent Reviews Call BookMore Details
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Fairfield Inn & Suites by Marriott Jacksonville Be : 1616 1st St. North
+1-888-878-9982
1616 1st St. North, Jacksonville Beach, FL 32250 ~3.92 miles northeast of Mayo Clinic
  • Affordable Beach hotel
  • 2 meeting rooms in hotel
From$129
Very Good 4.0 /5 Read Reviews Call BookMore Details
Courtyard by Marriott Oceanfront Jacksonville Beac
+1-888-389-4485
1617 1st St. North, Jacksonville Beach, FL 32250 ~3.93 miles northeast of Mayo Clinic
  • Affordable Beach property
  • 150 rooms in property
From$159
Very Good 4.5 /5 Reviews Call BookMore Details
Red Roof Inn PLUS+ Neptune Beach - Jacksonville Beach - Neptune Beach
+1-888-389-4121
1401 Atlantic Blvd., Neptune Beach, FL 32266 ~4.50 miles north of Mayo Clinic
  • 3 star Beach hotel
  • Check in: 03:00 PM
From$53
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Holiday Inn Express & Suites Jacksonville Town Center
+1-888-675-2083
10573 Brightman Blvd., Jacksonville, FL 32246 ~4.96 miles west of Mayo Clinic
  • Midscale Downtown hotel
  • Hotel has an eco-friendly policy See more
From$89
Very Good 4.0 /5 Read Reviews Call BookMore Details
The Lodge and Club at Ponte Vedra Beach : 607 Ponte Vedra Blvd.
+1-800-716-8490
607 Ponte Vedra Blvd., Ponte Vedra Beach, FL 32082 ~4.96 miles southeast of Mayo Clinic
  • Luxury Five Star property
  • Hotel has 2 floors
From$250
Very Good 4.0 /5 Read Reviews Call BookMore Details
One Ocean Resort and Spa in Atlantic Beach
+1-800-805-5223
1 Ocean Blvd., Atlantic Beach, FL 32233 ~5.01 miles northeast of Mayo Clinic
  • Four-star Beach hotel
  • Check in time: 3:00pm
From$131
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
+1-888-965-1860
45 Tournament Players Club Blvd., Ponte Vedra Beach, FL 32082 ~5.10 miles southeast of Mayo Clinic
  • Three Star Resort property
  • Check in: 03:00 PM
From$129
Very Good 4.5 /5 Review Score Call BookMore Details
Sawgrass Marriott Golf Resort & Spa - Ponte Vedra Beach
+1-888-788-5576
1000 Pga Tour Blvd., Ponte Vedra Beach, FL 32082 ~5.15 miles southeast of Mayo Clinic
  • High end Beach hotel
  • 36 conference rooms in property
From$129
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Holiday Inn Jacksonville E 295 Baymeadows, an IHG Hotel : 11083 Nursery Fields Dr.
+1-888-897-9207
11083 Nursery Fields Dr., Jacksonville, FL 32256 ~5.34 miles southwest of Mayo Clinic
  • Three Star Suburban property
  • Hotel has a green policy See more
From$109
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Homewood Suites by Hilton Jacksonville-South/St. Johns Ctr. in Jacksonville
+1-888-311-4278
10434 Midtown Pkwy., Jacksonville, FL 32246 ~5.41 miles west of Mayo Clinic
  • Mid-scale Suburban hotel
  • Check-in: 4:00 pm
From$129
Very Good 4.0 /5 Recent Reviews Call BookMore Details

Next: Show All Available Mayo Clinic Hotels with Pricing

Bar Chart: Upcoming 20 Days of Mayo Clinic Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Pablo Keys, FL discounts available. The chart reflects the cheapest Pablo Keys hotel for each day and each star rating category.

What are the best hotels near Mayo Clinic?

HotelDescriptionLink
1. Courtyard by Marriott Jacksonville at Mayo Clinic Campus The Courtyard by Marriott Jacksonville at Mayo Clinic Campus is a popular 3-Star hotel located approx. 0.1 miles southwest of Mayo Clinic and roughly a 1 minute stroll by foot. Recent hotel guests gave this hotel a verified guest score of 4/5. Get the latest price
2. Inn at Mayo Clinic The Inn at Mayo Clinic is a favored 3-Star hotel located ~0.2 mi. north of Mayo Clinic and approx. a 3 minute walk by foot. With a verified guest score of 4/5, this makes it one of the most desirable hotels nearby Mayo Clinic. Get the latest price
3. Residence Inn Jacksonville East The Residence Inn Jacksonville East is an in demand 3-Star hotel located approx. 0.5 miles south of Mayo Clinic and roughly a 9 minute stroll by foot. Recent hotel guests gave this hotel a verified guest score of 5/5. Get the latest price
4. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area, an IH The Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area, an IH is a popular 3 star hotel located approx. 1.7 miles west of Mayo Clinic and about a 3 min. drive. Recent guests gave this hotel an avg. guest review rating of 4 out of 5. Get the latest price
5. Hampton Inn Jacksonville The Hampton Inn Jacksonville is a popular 3 star hotel located approx. 2.4 miles east of Mayo Clinic and about a 4 min. drive. With a guest review score of 4 out of 5, this makes it one of the first-class hotel options close to Mayo Clinic. Get the latest price

5 Best Hotels near Mayo Clinic

FAQs about hotels near Mayo Clinic

What are the most favored hotels near Mayo Clinic?

Residence Inn Jacksonville East, Courtyard by Marriott Oceanfront Jacksonville Beac and Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass are the best rated hotels based on customer reviews in the last 365 days.

What are the most up-scale hotels near Mayo Clinic?

Enso, Ponte Vedra Beach Resorts and The Lodge and Club at Ponte Vedra Beach are the top 3 luxury hotels near Mayo Clinic.

What hotels are closest to the area of Mayo Clinic?

Courtyard by Marriott Jacksonville at Mayo Clinic Campus, The Inn at Mayo Clinic, and Residence Inn Jacksonville East are the properties closest to Mayo Clinic.

What are the most popular independent hotels near Mayo Clinic?

The Inn at Mayo Clinic, Margaritaville Jacksonville and Ponte Vedra Beach Resorts are the best rated independent hotels (not part of a big brand).

What are the best Marriott hotels near Mayo Clinic?

Residence Inn Jacksonville East, Courtyard by Marriott Oceanfront Jacksonville Beac and Courtyard by Marriott Jacksonville at Mayo Clinic Campus are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the best IHG hotels near Mayo Clinic?

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area, an IH, Holiday Inn Express Jacksonville Beach, an IHG Hotel and Holiday Inn Express & Suites Jacksonville Town Center are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

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