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Hotels Near Mayo Clinic Florida

Accommodations close to Mayo Clinic are shown in the list below sorted in the order of their distance (closest first). Browse our hotels to find accommodations near Mayo Clinic (Mayo Clinic) for your leisure or corporate trips. Mayo Clinic is located at 4500 San Pablo Rd S. We show the best lodging close to Mayo Clinic so you can review the available Mayo Clinic lodging below and securely book your ideal hotel.

Lodging & Accommodations close by Mayo Clinic

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
14390 Mayo Blvd., Jacksonville, FL 32224 +1-888-389-4121 ~0.08 miles southwest of Mayo Clinic
~1 minute walk
  • Mid-scale Beach property
  • 2 meeting rooms in hotel
  • Most guests criticized the unstylish hotel
  • Great location
More Photos Exterior of Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
From$50
Very Good 4.0 /5 Latest Reviews Call BookMore Details
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The Inn at Mayo Clinic
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
4420 Mary Brigh Dr., Jacksonville, FL 32224 +1-888-675-2083 ~0.24 miles north of Mayo Clinic
~4 minute walk
  • Mid-scale Beach hotel
  • Complimentary breakfast is offered
More Photos Image of The Inn at Mayo Clinic
From$99
Very Good 4.0 /5 Read Reviews Call BookMore Details
Residence Inn Jacksonville East
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
4905 San Pablo Rd. South, Jacksonville, FL 32224 +1-800-716-8490 ~0.51 miles south of Mayo Clinic
~9 minute walk
  • Three Star property
  • Check in time: 15:00
More Photos hotel room
From$90
Excellent 5.0 /5 Review Score Call BookMore Details
Holiday Inn Express & Suites Jacksonville Se Med Center Area An I
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
4791 Windsor Commons Court Jacksonville Fl 3222, Jacksonville, FL 32224 +1-800-805-5223 ~1.71 miles west of Mayo Clinic
  • Midscale Golf Course property
  • 4 conference rooms in property
  • Close to restaurants, bars and shopping areas
  • Bathroom could be optimized
More Photos Image of Holiday Inn Express & Suites Jacksonville Se Med Center Area An I
From$97
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Towneplace Stes East Marriott - Jacksonville
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
13741 Beach Blvd., Jacksonville, FL 32224 +1-888-965-1860 ~2.09 miles northwest of Mayo Clinic
  • 3-star property
  • Check-in: 15:00
More Photos hotel room
From$90
Average 3.0 /5 Recent Reviews Call BookMore Details
Hampton Inn & Suites Jacksonville Beach Blvd / Mayo Clinic - Jacksonville
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
13733 Beach Blvd., Jacksonville, FL 32224 +1-888-788-5576 ~2.13 miles northwest of Mayo Clinic
  • Affordable Suburban hotel
  • Check-in: 3:00 pm
More Photos Image of Hampton Inn & Suites Jacksonville Beach Blvd / Mayo Clinic
From$83
Very Good 4.0 /5 Review Score Call BookMore Details
Hampton Inn Jacksonville / Ponte Vedra Beach Mayo Clinic Area in Jacksonville Beach
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
1220 Marsh Landing Pkwy., Jacksonville Beach, FL 32250 +1-888-897-9207 ~2.43 miles east of Mayo Clinic
  • Three Star Beach property
  • 5 floors in property
More Photos Photo of Hampton Inn Jacksonville / Ponte Vedra Beach Mayo Clinic Area
From$99
Very Good 4.0 /5 Review Score Call BookMore Details
Holiday Inn Express Jacksonville Beach An Ihg Hotel in Jacksonville Beach
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
1101 Beach Blvd., Jacksonville Beach, FL 32250 +1-888-311-4278 ~2.84 miles northeast of Mayo Clinic
  • 3 star Beach hotel
  • 82 rooms in property
More Photos Photo of Holiday Inn Express Jacksonville Beach An Ihg Hotel
From$80
Very Good 4.0 /5 Review Score Call BookMore Details
Four Points by Sheraton Jacksonville Beachfront - Jacksonville Beach
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
11 1st St. North, Jacksonville Beach, FL 32250 +1-888-469-4795 ~3.40 miles northeast of Mayo Clinic
  • Affordable Beach property
  • 2 conference rooms in property
  • Great design
  • Rather comfortable
More Photos Photo of Four Points by Sheraton Jacksonville Beachfront
From$130
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Best Western Oceanfront : 305 1st St. North
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
305 1st St. North, Jacksonville Beach, FL 32250 +1-888-734-9421 ~3.49 miles northeast of Mayo Clinic
  • 3 star Beach hotel
  • Has environment-friendly policy Read more
More Photos Photo of Best Western Oceanfront
From$68
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Casa Marina Hotel
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
691 1st St. North, Jacksonville Beach, FL 32250 +1-888-841-5292 ~3.60 miles northeast of Mayo Clinic
  • Three Star Oceanfront hotel
  • Hotel has 3 meeting rooms
  • Most guests thought the view was good
  • Parking is rare
More Photos Image of Casa Marina Hotel
From$110
Average 3.5 /5 Latest Reviews Call BookMore Details
Margaritaville Jacksonville
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
715 1st St. North, Jacksonville, FL 32250 +1-888-455-5160 ~3.63 miles northeast of Mayo Clinic
  • Four-star property
  • Hotel has 172 rooms
More Photos hotel room
From$200
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Ponte Vedra Beach Resorts - Ponte Vedra Beach
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
200 Ponte Vedra Blvd., Ponte Vedra Beach, FL 32082 +1-888-965-8297 ~3.78 miles east of Mayo Clinic
  • Luxury 5 star Beach property
  • Check-in: 4:00 PM
  • Rather comfortable
  • Only complaint was that pool
More Photos Photo of Ponte Vedra Beach Resorts
From$179
Very Good 4.0 /5 Guest Reviews Call BookMore Details
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Hampton Inn Oceanfront Jax Beach : 1515 1st St. North
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
1515 1st St. North, Jacksonville Beach, FL 32250 +1-888-906-6358 ~3.91 miles northeast of Mayo Clinic
  • Affordable Oceanfront property
  • Hotel has 2 meeting rooms
  • Tasty breakfast
  • Shower can be a problem
More Photos Photo of Hampton Inn Oceanfront Jax Beach
From$119
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Fairfield Inn & Suites by Marriott Jacksonville Be
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
1616 1st St. North, Jacksonville Beach, FL 32250 +1-888-749-6785 ~3.92 miles northeast of Mayo Clinic
  • 3 star Beach property
  • 76 sleeping rooms in hotel
  • Awesome vibe
  • Great service
More Photos Image of Fairfield Inn & Suites by Marriott Jacksonville Be
From$129
Very Good 4.0 /5 Reviews Call BookMore Details
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Courtyard by Marriott Oceanfront Jacksonville Beac in Jacksonville Beach
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
1617 1st St. North, Jacksonville Beach, FL 32250 +1-888-878-9982 ~3.93 miles northeast of Mayo Clinic
  • Three Star Beach hotel
  • 7 floors in property
  • Great shower
  • Most guests found the staff to be very friendly
More Photos Photo of Courtyard by Marriott Oceanfront Jacksonville Beac
From$159
Very Good 4.5 /5 Review Score Call BookMore Details
Red Roof Inn PLUS+ Neptune Beach - Jacksonville Beach
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
1401 Atlantic Blvd., Neptune Beach, FL 32266 +1-888-389-4485 ~4.50 miles north of Mayo Clinic
  • 3-star Beach property
  • 129 rooms in hotel
More Photos Photo of Red Roof Inn PLUS+ Neptune Beach - Jacksonville Beach
From$53
Very Good 4.0 /5 Read Reviews Call BookMore Details
Holiday Inn Express & Suites Jacksonville Town Center
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
10573 Brightman Blvd., Jacksonville, FL 32246 +1-888-389-4121 ~4.96 miles west of Mayo Clinic
  • Three Star Downtown hotel
  • Check-in time: 3:00 PM
More Photos Photo of Holiday Inn Express & Suites Jacksonville Town Center
From$89
Very Good 4.0 /5 Latest Reviews Call BookMore Details
The Lodge and Club at Ponte Vedra Beach
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
607 Ponte Vedra Blvd., Ponte Vedra Beach, FL 32082 +1-888-675-2083 ~4.96 miles southeast of Mayo Clinic
  • Luxury 5-star property
  • Check-in time: 16:00
More Photos Exterior of The Lodge and Club at Ponte Vedra Beach
From$250
Very Good 4.0 /5 Recent Reviews Call BookMore Details
One Ocean Resort and Spa in Atlantic Beach
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
1 Ocean Blvd., Atlantic Beach, FL 32233 +1-800-716-8490 ~5.01 miles northeast of Mayo Clinic
  • High-end Beach hotel
  • 3 suites in hotel
  • Great view
  • Great menu
More Photos Image of One Ocean Resort and Spa
From$131
Very Good 4.0 /5 Read Reviews Call BookMore Details
Hilton Garden Inn Jacksonville / Ponte Vedra : 45 Pga Tour Blvd.
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
45 Pga Tour Blvd., Ponte Vedra Beach, FL 32082 +1-800-805-5223 ~5.10 miles southeast of Mayo Clinic
  • 3 star Resort hotel
  • Fitness / Gym is on-site
More Photos Exterior of Hilton Garden Inn Jacksonville / Ponte Vedra
From$129
Very Good 4.5 /5 Reviews Call BookMore Details
Sawgrass Marriott Golf Resort & Spa
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
1000 Pga Tour Blvd., Ponte Vedra Beach, FL 32082 +1-888-965-1860 ~5.15 miles southeast of Mayo Clinic
  • Expensive Beach hotel
  • Gym / Fitness Center Available
  • AC needs updating
  • Bar is ok
More Photos Exterior of Sawgrass Marriott Golf Resort & Spa
From$129
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Holiday Inn Jacksonville E 295 Baymeadows, an IHG Hotel
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
11083 Nursery Fields Dr., Jacksonville, FL 32256 +1-888-788-5576 ~5.34 miles southwest of Mayo Clinic
  • 3-star Suburban property
  • 98 rooms in hotel
  • Amenities are good
  • The majority of guests found the staff to be very friendly
More Photos Exterior of Holiday Inn Jacksonville E 295 Baymeadows, an IHG Hotel
From$109
Very Good 4.0 /5 Read Reviews Call BookMore Details
Homewood Suites by Hilton Jacksonville South / St. Johns Center - Jacksonville
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
10434 Midtown Pkwy., Jacksonville, FL 32246 +1-888-897-9207 ~5.41 miles west of Mayo Clinic
  • 3 star Suburban property
  • Hotel has 119 suites
More Photos Photo of Homewood Suites by Hilton Jacksonville South / St. Johns Center
From$129
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Hyatt Place Jacksonville / St. Johns Town Center
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
4742 Town Center Pkwy., Jacksonville, FL 32246 +1-888-311-4278 ~5.52 miles west of Mayo Clinic
  • Affordable hotel
  • Hotel has 160 suites
More Photos Exterior of Hyatt Place Jacksonville / St. Johns Town Center
From$115
Very Good 4.0 /5 Read Reviews Call BookMore Details

Next: Show All Available Mayo Clinic Hotels with Pricing

Bar Chart: Upcoming 20 Days of Mayo Clinic Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Pablo Keys, FL discounts available. The chart reflects the cheapest Pablo Keys hotel for each day and each star rating category.

What are the best hotels near Mayo Clinic?

HotelDescriptionLink
1. Courtyard by Marriott Jacksonville at Mayo Clinic Campus The Courtyard by Marriott Jacksonville at Mayo Clinic Campus is a popular 3-Star hotel located approx. 0.1 miles southwest of Mayo Clinic and roughly a 1 minute stroll by foot. Recent hotel guests gave this hotel a verified guest score of 4/5. Get the latest price
2. Inn at Mayo Clinic The Inn at Mayo Clinic is a favored 3-Star hotel located ~0.2 mi. north of Mayo Clinic and approx. a 3 minute walk by foot. With a verified guest score of 4/5, this makes it one of the most desirable hotels nearby Mayo Clinic. Get the latest price
3. Residence Inn Jacksonville East The Residence Inn Jacksonville East is an in demand 3-Star hotel located approx. 0.5 miles south of Mayo Clinic and roughly a 9 minute stroll by foot. Recent hotel guests gave this hotel a verified guest score of 5/5. Get the latest price
4. Holiday Inn Express & Suites Jacksonville Se Med Center Area An I The Holiday Inn Express & Suites Jacksonville Se Med Center Area An I is a popular 3 star hotel located approx. 1.7 miles west of Mayo Clinic and about a 3 min. drive. With a guest review score of 4 out of 5, this makes it one of the finest hotels close to Mayo Clinic. Get the latest price
5. Hampton Inn & Suites Jacksonville Beach Blvd The Hampton Inn & Suites Jacksonville Beach Blvd is an in demand 3 star hotel located approx. 2.1 miles northwest of Mayo Clinic and approximately a 4 min. car ride. With a aggregate guest review score of 4 out of 5, this makes it one of the terrific hotels close to Mayo Clinic. Get the latest price

5 Best Hotels near Mayo Clinic

FAQs about hotels near Mayo Clinic

What are the most favored hotels near Mayo Clinic?

Residence Inn Jacksonville East, Courtyard by Marriott Oceanfront Jacksonville Beac and Hilton Garden Inn Jacksonville are the best rated hotels based on customer reviews in the last 365 days.

What are the most high-end hotels near Mayo Clinic?

Ponte Vedra Beach Resorts, The Lodge and Club at Ponte Vedra Beach and Margaritaville Jacksonville are the top 3 luxury hotels near Mayo Clinic.

What hotels are closest to the area of Mayo Clinic?

Courtyard by Marriott Jacksonville at Mayo Clinic Campus, The Inn at Mayo Clinic, and Residence Inn Jacksonville East are the properties closest to Mayo Clinic.

What are the most popular independent hotels near Mayo Clinic?

The Inn at Mayo Clinic, Margaritaville Jacksonville and Ponte Vedra Beach Resorts are the best rated independent hotels (not part of a big brand).

What are the best Marriott hotels near Mayo Clinic?

Residence Inn Jacksonville East, Courtyard by Marriott Oceanfront Jacksonville Beac and Courtyard by Marriott Jacksonville at Mayo Clinic Campus are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the best IHG hotels near Mayo Clinic?

Holiday Inn Express & Suites Jacksonville Se Med Center Area An I, Holiday Inn Express Jacksonville Beach An Ihg Hotel and Holiday Inn Express & Suites Jacksonville Town Center are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

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