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Greenville Illinois Hotels & Motels

Find hotels in Greenville using the list and search tools below. Find cheap and discounted hotel/motel rates in or nearby Greenville, IL for your upcoming personal or group travel. Discover the most popular Greenville, Illinois hotel and motel rooms. Browse the Greenville area hotels to find the perfect lodging! Please use the provided map of the Greenville hotels.

The Greenville center is around the area of Edward A Utlaut Hospital and 17 miles west of Fayette County Museum.

Greenville Hotels, Motels & Accommodations

Super 8 by Wyndham Greenville : 1700 State Route 127 1700 State Route 127, Greenville, IL 62246
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  • Economy Rural property
  • Free comp. breakfast
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From£45
Average 3.0 /5 Hotel Reviews Call BookMore Details
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SureStay by Best Western Greenville 1731 South State Route 127, Greenville, IL 62246
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  • Low priced Highway property
  • Free complimentary breakfast
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From£31
Average 3.0 /5 Review Score Call BookMore Details
Comfort Inn & Suites Greenville I-70 in Greenville 2265 South State Route 127, Greenville, IL 62246 Website
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  • 2-star Rural hotel
  • Hotel has 3 floors
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From£40
Very good 4.0 /5 Latest Reviews Call BookMore Details
Holiday Inn Express & Suites Vandalia Il 21 Mattes Ave., Vandalia, IL 62471
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~15.52 miles east of Greenville
  • Three Star Highway property
  • Has environment-friendly policy See policy
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From£60
Average 3.0 /5 Hotel Reviews Call BookMore Details
Ramada by Wyndham Vandalia : 2707 Veterans Ave. 2707 Veterans Ave., Vandalia, IL 62471
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~15.77 miles east of Greenville
  • Low Cost hotel
  • Check in time: 11:00 AM
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From£45
Average 3.0 /5 Read Reviews Call BookMore Details
Americas Best Value Inn Vandalia 1500 North 6th St., Vandalia, IL 62471
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~17.45 miles east of Greenville
  • Two-star Lake hotel
  • Check-in time: 3.00
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From£37
Average 3.0 /5 Reviews Call BookMore Details
Quality Inn & Suites Vandalia near I-70 and Hwy 51 in Vandalia 1920 North Kennedy Blvd., Vandalia, IL 62471 Website
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~17.57 miles east of Greenville
  • Cheap Highway hotel
  • Hotel has 2 floors
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From£45
Very good 4.0 /5 Latest Reviews Call BookMore Details
Quality Inn & Suites Vandalia near I-70 and Hwy 51 - Vandalia 1920 Kennedy Blvd., Vandalia, IL 62471
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~17.59 miles east of Greenville
  • Economical Rural property
  • 85 rooms in property
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From£43
Very good 4.5 /5 Guest Reviews Call BookMore Details
Seasons Inn & Suites Highland - Highland 20 Central Blvd., Highland, IL 62249
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~17.74 miles southwest of Greenville
  • Cheap property
  • Check in: 3:00 PM
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From£49
Average 3.0 /5 Read Reviews Call BookMore Details
Mariner's Village Resort & Inn 1 Resort Dr., Carlyle, IL 62231
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~18.34 miles south of Greenville
  • Two star Lake hotel
  • Free comp. breakfast
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From£44
Very good 4.0 /5 Review Score Call BookMore Details
Centerstone Inn & Suites - Carlyle 1371 William Rd., Carlyle, IL 62231
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~18.46 miles south of Greenville
  • Two-star hotel
  • Check in: 3:00 PM
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From£45
Average 3.0 /5 Reviews Call BookMore Details
Super 8 by Wyndham Staunton 1527 Herman Rd., Staunton, IL 62088
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~21.09 miles west of Greenville
  • Inexpensive property
  • Free breakfast available
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From£37
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Innkeeper Motel 401 East State St., Hamel, IL 62046
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~23.07 miles west of Greenville
  • Affordable Lake hotel
  • Hotel has 2 floors
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From£60
Average 3.0 /5 Read Reviews Call BookMore Details
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Americas Best Value Inn Litchfield 224 North Ohren Lane, Litchfield, IL 62056
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~24.10 miles northwest of Greenville
  • Two-star hotel
  • Hotel has 65 rooms
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From£45
Poor 2.0 /5 Recent Reviews Call BookMore Details
Motel 6 Litchfield, IL 211 Ohren Ln, Litchfield, IL 62056
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~24.16 miles northwest of Greenville
  • Cheap Highway property
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From£45
Average 3.0 /5 Recent Reviews Call BookMore Details
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Baymont by Wyndham Litchfield in Litchfield 1405 West Hudson Dr., Litchfield, IL 62056
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~24.16 miles northwest of Greenville
  • Low Cost Highway property
  • 5 suites in property
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From£45
Very good 4.0 /5 Guest Reviews Call BookMore Details
Quality Inn Litchfield Route 66 in Litchfield 1010 East Columbian Blvd. North, Litchfield, IL 62056 Website
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~24.37 miles northwest of Greenville
  • 2-star Downtown hotel
  • Hotel has 3 floors
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From£53
Very good 4.5 /5 Guest Reviews Call BookMore Details
Hampton Inn Litchfield 11 Thunderbird Cir, Litchfield, IL 62056
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~24.48 miles northwest of Greenville
  • Midscale Highway property
  • 64 sleeping rooms in hotel
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From£60
Average 3.0 /5 Review Score Call BookMore Details
Holiday Inn Express & Suites Litchfield West by IHG - Litchfield 4 Thunderbird Circle, Litchfield, IL 62056
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~24.49 miles northwest of Greenville
  • Affordable Rural hotel
  • Check-in: 15:00
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From£59
Very good 4.0 /5 Read Reviews Call BookMore Details
Best Western Plus Centralia Hotel & Suites in Centralia 8145 Jolliff Bridge Rd., Centralia, IL 62801
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~28.09 miles southeast of Greenville
  • Mid-scale hotel
  • Complimentary breakfast is offered
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From£59
Very good 4.0 /5 Guest Reviews Call BookMore Details
Americas Best Value Inn in Centralia 200 East Noleman, Centralia, IL 62801
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~29.09 miles southeast of Greenville
  • Low priced property
  • 57 rooms in hotel
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From£45
Very good 4.0 /5 Read Reviews Call BookMore Details
Motel 6 Troy Il 909 Edwardsville Rd., Troy, IL 62294
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~29.31 miles west of Greenville
  • Two star property
  • 2 floors in hotel
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From£37
Average 3.0 /5 Recent Reviews Call BookMore Details
Quality Inn & Suites Salem near I-57 in Salem 1800 West Main St., Salem, IL 62881 Website
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~29.38 miles southeast of Greenville
  • Low priced Rural hotel
  • 3 floors in property
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From£52
Very good 4.0 /5 Guest Reviews Call BookMore Details
Best Western Troy Hotel : 2020 Formosa Rd. 2020 Formosa Rd., Troy, IL 62294
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~29.44 miles west of Greenville
  • Affordable Rural property
  • Gym / Fitness Center Available
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From£45
Average 3.5 /5 Recent Reviews Call BookMore Details
Holiday Inn Express Troy by IHG 2011 Formosa Rd., Troy, IL 62294
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~29.51 miles west of Greenville
  • Mid-scale Highway hotel
  • 2 meeting rooms in hotel
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From£63
Very good 4.5 /5 Guest Reviews Call BookMore Details
Red Roof Inn St Louis - Troy, IL 2030 Formosa Rd., Troy, IL 62294
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~29.55 miles west of Greenville
  • Economical hotel
  • 8 suites in hotel
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From£40
Very good 4.0 /5 Review Score Call BookMore Details
Days Inn by Wyndham Salem, Illinois - Salem 1812 West Main St., Salem, IL 62881
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~29.55 miles southeast of Greenville
  • Low-priced property
  • Hotel has 94 rooms
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From£35
Very good 4.0 /5 Review Score Call BookMore Details
Super 8 by Wyndham Troy IL/St. Louis Area 910 Edwardsville Rd., Troy, IL 62294
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~29.60 miles west of Greenville
  • Two-star Highway hotel
  • 2 floors in property
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From£47
Average 3.0 /5 Latest Reviews Call BookMore Details
Super 8 by Wyndham Salem - Salem 118 Woods Ln, Salem, IL 62881
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~29.63 miles southeast of Greenville
  • Economy Highway property
  • Free breakfast
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From£45
Average 3.0 /5 Guest Reviews Call BookMore Details
Magnuson Grand Hotel And Conference Center in Raymond 19067 West Frontage Rd., Raymond, IL 62560
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~29.70 miles northwest of Greenville
  • Three Star Rural property
  • 97 rooms in hotel
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From£37
Very good 4.0 /5 Recent Reviews Call BookMore Details
Holiday Inn Express & Suites Salem by IHG : 102 Holiday Lane 102 Holiday Lane, Salem, IL 62881
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~29.89 miles southeast of Greenville
  • Mid-scale Highway property
  • Hotel has an eco-friendly policy See more
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From£65
Excellent 5.0 /5 Guest Reviews Call BookMore Details
Holiday Inn Express & Suites Edwardsville by IHG 1000 Plummer Dr., Edwardsville, IL 62025
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~31.59 miles west of Greenville
  • Midscale Suburban hotel
  • 101 sleeping rooms in hotel
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From£71
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Country Hearth Inn & Suites Edwardsville St. Louis 1013 Plummer Dr., Edwardsville, IL 62025
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~31.66 miles west of Greenville
  • Mid-scale Rural property
  • Check-in: 15:00
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From£50
Very good 4.0 /5 Guest Reviews Call BookMore Details
Towneplace Suites by Marriott St. Louis Edwardsville Il in Edwardsville 6101 Center Grove Rd., Edwardsville, IL 62025
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~31.67 miles west of Greenville
  • Mid-scale Suburban property
  • Check-in time: 15:00
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From£68
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Best Western Plus MidAmerica Hotel : 9730 Hayden Dr. 9730 Hayden Dr., Mascoutah, IL 62258
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~32.05 miles southwest of Greenville
  • Mid-scale Suburban hotel
  • Free comp. breakfast
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From£52
Very good 4.0 /5 Read Reviews Call BookMore Details
Super 8 by Wyndham Okawville - Okawville 812 North Henhouse Rd., Okawville, IL 62271
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~32.28 miles south of Greenville
  • Cheap Rural property
  • 2 suites in hotel
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From£48
Average 3.0 /5 Latest Reviews Call BookMore Details
Super 8 by Wyndham Okawville 812 North Hen House Rd., Okawville, IL 62271
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~32.28 miles south of Greenville
  • Low-priced property
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From£45
Average 3.0 /5 Latest Reviews Call BookMore Details
Super 8 by Wyndham O'fallon 1100 Eastgate Dr., Ofallon, IL 62269
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~33.41 miles southwest of Greenville
  • Two-star Suburban hotel
  • Comp. Breakfast
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From£30
Average 3.0 /5 Latest Reviews Call BookMore Details
Comfort Inn Edwardsville - St. Louis - Edwardsville 3080 South State Rte 157, Edwardsville, IL 62025 Website
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~33.44 miles west of Greenville
  • Economical Highway property
  • Hotel has 4 suites
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From£45
Average 3.0 /5 Guest Reviews Call BookMore Details
Hampton Inn & Suites St. Louis Edwardsville : 5723 Heritage Crossing Dr. 5723 Heritage Crossing Dr., Glen Carbon, IL 62034
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~33.74 miles west of Greenville
  • Mid-scale Suburban hotel
  • Hotel has 72 rooms
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From£75
Very good 4.0 /5 Guest Reviews Call BookMore Details
Best Western U. S. Inn : 11640 State Route 127 11640 State Route 127, Nashville, IL 62263
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~35.22 miles south of Greenville
  • Three Star Highway hotel
  • 48 rooms in hotel
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From£46
Very good 4.0 /5 Reviews Call BookMore Details
Sleep Inn O Fallon Il in O'fallon 140 Venita Dr., O'fallon, IL 62269
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~35.35 miles southwest of Greenville
  • 3 star Suburban property
  • Hotel has 3 floors
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From£60
Average 3.0 /5 Guest Reviews Call BookMore Details
Holiday Inn Express & Suites O'fallon / Shiloh An Ihg Hotel in Shiloh 3396 Green Mount Crossing, Shiloh, IL 62269
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~35.48 miles southwest of Greenville
  • Affordable Highway property
  • 2 meeting rooms in property
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From£75
Very good 4.0 /5 Recent Reviews Call BookMore Details
Comfort Inn & Suites Ofallon St. Louis Area : 116 Regency Park 116 Regency Park, O'fallon, IL 62269
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~35.51 miles southwest of Greenville
  • Two star Suburban hotel
  • 3 floors in hotel
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From£45
Average 3.0 /5 Latest Reviews Call BookMore Details
Hampton Inn O'fallon Il 430 Regency Park, O'fallon, IL 62269
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~35.57 miles southwest of Greenville
  • Affordable Suburban property
  • 100 rooms in hotel
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From£60
Very good 4.0 /5 Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham O'fallon Il St. Louis in O'fallon 136 Regency Park, O'fallon, IL 62269
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~35.59 miles southwest of Greenville
  • 2-star Suburban hotel
  • Free comp. breakfast
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From£45
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Hilton Garden Inn St. Louis Shiloh / O'fallon Il in O'fallon 360 Regency Park, O'fallon, IL 62269
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~35.65 miles southwest of Greenville
  • Affordable Suburban property
  • 20 suites in hotel
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From£60
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Extended Stay America Select Suites - St. Louis - O' Fallon, IL : 154 Regency Park 154 Regency Park, O'fallon, IL 62269
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~35.68 miles southwest of Greenville
  • Low Cost Highway hotel
  • Hotel has 89 rooms
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From£29
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Welcome Suites in O'fallon 148 Regency Park, O'fallon, IL 62269
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~35.68 miles southwest of Greenville
  • 2 star Suburban property
  • 3 floors in property
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From£30
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Towneplace Place Suites by Marriott St. Louis O Fallon Illinois - Ofallon 445 Regency Park Dr., Ofallon, IL 62269
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~35.68 miles southwest of Greenville
  • 3 star hotel
  • 89 suites in property
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From£68
Very good 4.0 /5 Review Score Call BookMore Details

Next: See My Greenville Hotels with Pricing

Graph: Upcoming 20 Days of Greenville Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Greenville, IL discounts available. The chart reflects the cheapest Greenville hotel for each day and each star rating category.

FAQs about hotels in Greenville

What are the top reviewed hotels in Greenville?

Holiday Inn Express & Suites Salem by IHG, Quality Inn & Suites Vandalia near I-70 and Hwy 51 and Quality Inn Litchfield Route 66 are the best rated hotels based on customer reviews in the last 365 days.

What are the upper-end hotels in Greenville?

Holiday Inn Express & Suites Vandalia Il, Innkeeper Motel and Hampton Inn Litchfield are the top 3 luxury hotels near Greenville city center.

What hotels are closest to the city center of Greenville?

Super 8 by Wyndham Greenville, SureStay by Best Western Greenville, and Comfort Inn & Suites Greenville I-70 are the properties closest to Greenville city center.

What are the best independent hotels in Greenville?

Mariner's Village Resort & Inn, Magnuson Grand Hotel And Conference Center and Welcome Suites are the best rated independent hotels (not part of a big brand).

What are the most popular Marriott hotels in Greenville?

Towneplace Suites by Marriott St. Louis Edwardsville Il and Towneplace Place Suites by Marriott St. Louis O Fallon Illinois are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the most popular Choice Hotels branded hotels in Greenville?

Quality Inn & Suites Vandalia near I-70 and Hwy 51, Quality Inn Litchfield Route 66 and Comfort Inn & Suites Greenville I-70 are the best rated Choice Hotels branded hotels (based on HotelPlanner reviews score).

What are the most popular Best Western hotels in Greenville?

Best Western Plus Centralia Hotel & Suites, Best Western Plus MidAmerica Hotel and Best Western U. S. Inn are the best rated Best Western branded hotels (based on user reviews score).

What are the most popular IHG hotels in Greenville?

Holiday Inn Express & Suites Salem by IHG, Holiday Inn Express Troy by IHG and Holiday Inn Express & Suites Litchfield West by IHG are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

Verified reviews of the city of Greenville

Below are reviews of the city of Greenville, IL from an actual visitor's perspective.

"Quiet town"
Score 4.0 / 5

Quiet town and my Son plays Basketball for Greenville university.

Newton A., from 26-Feb-2026
"Great Diner!"
Score 4.0 / 5

Vicky's Cafe was awesome!! Very helpful and polite staff! Clean diner with great food!

Amy S., from 24-Aug-2025
"Dressed up Strip area."
Score 4.0 / 5

They have dressed up the hotel strip area since our last visit.

Phillip D., from 22-Jun-2025
"Quiet Area"
Score 5.0 / 5

Quietness compared to the big city.

Marien C., from 09-Jul-2024
"Proximity to Carlyle"
Score 4.0 / 5

I was visiting family in Carlyle and this is the best location to stay.

Robin S., from 09-Jul-2024
"Greenville has some excellent museums!"
Score 5.0 / 5

Greenville has some excellent museums!

Hh K., from 17-Sep-2023
"Great Aquarium"
Score 4.0 / 5

I went to the aquarium which I thought was great!

Augustino P., from 26-Jun-2023
"College Campus"
Score 4.0 / 5

Visited the college campus.

Kelly M., from 13-Mar-2023
"Loved It!"
Score 5.0 / 5

Loved it all!

Tom W., from 28-Dec-2022
The average traveler rating of the city of Greenville, IL shown above is 4.3 out of 5 based on 9 reviews
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