Seneca South Carolina Hotels & Motels

Only hotels in Seneca are listed below. Search for cheap and discounted hotel and motel rates in or near Seneca, SC for your upcoming personal or group trip. We provide the best Seneca, South Carolina motel and hotel rooms. Browse the Seneca area hotels to find the perfect lodging! Please use the provided map of the Seneca hotels. Group booking? Search Seneca Group Hotel Discounts

The Seneca center point is about 6 miles west of Memorial Stadium and 6 miles west of Clemson Amtrak Station.

Known for its friendly atmosphere and small-town charm, Seneca, South Carolina, is just 10 miles west of Clemson. Whether you're visiting for work or fun, you'll appreciate the city's welcoming vibe, historic district, and beautiful setting. Get to know the City of Smiles and find out where to stay in Seneca. More from this guide...

Seneca Hotels/Motels & Accommodations

Grand Bohemian Lodge Greenville Autograph Collection 44 EAST CAMPERDOWN WAY, Greenville, SC 29601 +1-888-389-4121 ~33.33 miles east of Seneca
  • High-end hotel
  • 187 rooms in hotel
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Excellent 9.6 /10 Review Score Call BookMore Details
AC Hotel by Marriott Greenville 315 SOUTH MAIN STREET, Greenville, SC 29601 +1-888-675-2083 ~33.34 miles east of Seneca
  • Three Star hotel
  • 8 floors in hotel
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Excellent 9.2 /10 Recent Reviews Call BookMore Details
The Westin Poinsett Greenville 120 South Main St, Greenville, SC 296012711 +1-800-716-8490 ~33.44 miles east of Seneca
  • High-end property
  • Fitness + Health Center
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Excellent 9.4 /10 Recent Reviews Call BookMore Details
SpringHill Suites by Marriott Greenville Downtown 200 East Washington Street, Greenville, SC 29601 +1-800-805-5223 ~33.60 miles east of Seneca
  • Midscale property
  • 166 rooms in hotel
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Excellent 9.6 /10 Hotel Reviews Call BookMore Details
Embassy Suites by Hilton Greenville Downtown Riverplace 250 Riverplace, Greenville, SC 29601 +1-888-965-1860 ~33.20 miles east of Seneca
  • 3-star hotel
  • Check-in time: 4:00 PM - 1:00 AM
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Excellent 9.2 /10 Latest Reviews Call BookMore Details
Hyatt Place Greenville Downtown 128 East Broad Street, Greenville, SC 29601 +1-888-788-5576 ~33.49 miles east of Seneca
  • Three Star property
  • 130 sleeping rooms in hotel
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Very Good 8.8 /10 Reviews Call BookMore Details
Embassy Suites Greenville Golf Resort & Conference Center 670 Verdae Blvd, Greenville, SC 296074022 +1-888-897-9207 ~37.06 miles east of Seneca
  • Mid-scale Resort hotel
  • Pets are OK
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Very Good 8.7 /10 Review Score Call BookMore Details
Residence Inn by Marriott Greenville Downtown 200 East Washington Street, Greenville, SC 29601 +1-888-311-4278 ~33.60 miles east of Seneca
  • Mid-scale hotel
  • 120 rooms in hotel
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Excellent 9.4 /10 Reviews Call BookMore Details
Hyatt Regency Greenville 220 North Main St, Greenville, SC 296012129 +1-888-469-4795 ~33.63 miles east of Seneca
  • Midscale hotel
  • Hotel has 327 rooms
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Very Good 8.7 /10 Reviews Call BookMore Details
Courtyard by Marriott Greenville Downtown 50 West Broad St, Greenville, SC 296012610 +1-888-734-9421 ~33.33 miles east of Seneca
  • Mid-scale hotel
  • 9 suites in hotel
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Excellent 9.4 /10 Hotel Reviews Call BookMore Details
Home2 Suites by Hilton Greenville Downtown 350 North Main Street, Greenville, SC 29601 +1-888-841-5292 ~33.74 miles east of Seneca
  • Midscale property
  • Pets/Animals Allowed
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Excellent 9.2 /10 Reviews Call BookMore Details
Homewood Suites by Hilton Greenville Downtown 950 South Main Street, Greenville, SC 29601 +1-888-455-5160 ~32.82 miles east of Seneca
  • Mid-scale property
  • Access to gym on-site
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Excellent 9.6 /10 Hotel Reviews Call BookMore Details
Hampton Inn & Suites Greenville-Downtown-RiverPlace 171 Riverplace, Greenville, SC 29601 +1-888-965-8297 ~33.22 miles east of Seneca
  • Three Star property
  • 115 rooms in hotel
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Excellent 9.4 /10 Recent Reviews Call BookMore Details
Aloft by Marriott Greenville Downtown 5 North Laurens Street, Greenville, SC 29601 +1-888-906-6358 ~33.48 miles east of Seneca
  • Three Star hotel
  • Fitness center on property
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Excellent 9.2 /10 Latest Reviews Call BookMore Details
Holiday Inn Express & Suites Greenville - Downtown by IHG 407 North Main Street, Greenville, SC 29601 +1-888-749-6785 ~33.72 miles east of Seneca
  • Three Star property
  • Hotel has 5 floors
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Very Good 8.8 /10 Read Reviews Call BookMore Details
Hilton Greenville 45 West Orchard Park Dr, Greenville, SC 296153538 +1-888-878-9982 ~36.98 miles east of Seneca
  • Affordable hotel
  • 13 suites in hotel
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Very Good 8.4 /10 Reviews Call BookMore Details
DoubleTree by Hilton Greenville Woodruff Road 135 Carolina Point Parkway, Greenville, SC 29607 +1-888-389-4485 ~37.95 miles east of Seneca
  • Midscale hotel
  • Airport shuttle provided
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Excellent 9.2 /10 Guest Reviews Call BookMore Details
Holiday Inn Express Helen by IHG 8100 South Main Street, Helen, GA 30545 +1-888-389-4121 ~43.76 miles west of Seneca
  • Three Star property
  • 4 floors in property
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Very Good 8.8 /10 Latest Reviews Call BookMore Details
Greenville Marriott One Pkwy. E, Greenville, SC 29615 +1-888-675-2083 ~41.37 miles east of Seneca
  • Four star hotel
  • Pets are Allowed
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Very Good 8.6 /10 Read Reviews Call BookMore Details
Fairfield Inn & Suites by Marriott Helen 8035 South Main Street, Helen, GA 30545 +1-800-716-8490 ~43.68 miles west of Seneca
  • Midscale property
  • Hotel has 77 rooms
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Excellent 9.4 /10 Hotel Reviews Call BookMore Details
Residence Inn by Marriott Greenville 80 Carolina Point Parkway, Greenville, SC 29607 +1-800-805-5223 ~38.12 miles east of Seneca
  • 3-star property
  • Fitness center on property
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Excellent 9.2 /10 Latest Reviews Call BookMore Details
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG 851 Congaree Rd, Greenville, SC 296073521 +1-888-965-1860 ~37.78 miles east of Seneca
  • Midscale hotel
  • 2 suites in hotel
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Very Good 8.6 /10 Read Reviews Call BookMore Details
Courtyard Greenville-Spartanburg by Marriott 115 The Pkwy, Greer, SC 296155051 +1-888-788-5576 ~41.23 miles east of Seneca
  • Affordable hotel
  • Hotel has 5 floors
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Very Good 8.8 /10 Review Score Call BookMore Details
Courtyard by Marriott Greenville Haywood Mall 70 Orchard Park Dr, Greenville, SC 296153529 +1-888-897-9207 ~37.31 miles east of Seneca
  • 3-star property
  • 3 floors in hotel
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Very Good 8.8 /10 Recent Reviews Call BookMore Details
Greystone Inn 220 Greystone Ln, Lake Toxaway, NC 28747 +1-888-311-4278 ~31.35 miles north of Seneca
  • Three Star hotel
  • Gym / Fitness Center Available
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Excellent 9.4 /10 Review Score Call BookMore Details
Hampton Inn Helen 147 Unicoi Street, Helen, GA 30545 +1-888-469-4795 ~44.42 miles west of Seneca
  • Midscale property
  • Free complimentary breakfast
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Excellent 9.0 /10 Latest Reviews Call BookMore Details
Staybridge Suites Greenville I-85 Woodruff Road by IHG 31 Market Point Dr, Greenville, SC 296075768 +1-888-734-9421 ~38.28 miles east of Seneca
  • Mid-scale hotel
  • 3 floors in hotel
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Very Good 8.7 /10 Hotel Reviews Call BookMore Details
Hilton Garden Inn Greenville 108 Carolina Point Pkwy, Greenville, SC 296075765 +1-888-841-5292 ~38.32 miles east of Seneca
  • Mid-scale hotel
  • Pets Allowed
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Very Good 8.8 /10 Review Score Call BookMore Details
Hyatt Place Greenville / Haywood 40 West Orchard Park Dr, Greenville, SC 296153539 +1-888-455-5160 ~37.02 miles east of Seneca
  • Midscale property
  • 126 sleeping rooms in hotel
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Very Good 8.1 /10 Latest Reviews Call BookMore Details
Courtyard by Marriott Greenville Mauldin 100 MILLPORT CIRCLE, Greenville, SC 29607 +1-888-965-8297 ~38.95 miles east of Seneca
  • 3 star hotel
  • Check-in: 3:00 PM
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Excellent 9.1 /10 Hotel Reviews Call BookMore Details
Holiday Inn Greenville - Woodruff Road by IHG 25 OLD COUNTRY ROAD, Greenville, SC 29607 +1-888-906-6358 ~38.32 miles east of Seneca
  • Mid-scale property
  • Hotel has 100 rooms
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Very Good 8.6 /10 Read Reviews Call BookMore Details
Comfort Suites Greenville Airport 1371 Garlington Road, Greenville, SC 29615 +1-888-749-6785 ~41.23 miles east of Seneca
  • Midscale property
  • Hotel has an eco-friendly policy See more
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Very Good 8.9 /10 Reviews Call BookMore Details
Homewood Suites by Hilton Greenville 102 Carolina Point Pkwy, Greenville, SC 296075765 +1-888-878-9982 ~38.32 miles east of Seneca
  • Three Star property
  • Free comp. breakfast
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Excellent 9.0 /10 Reviews Call BookMore Details
The Abernathy of Clemson 157 Old Greenville Hwy, Clemson, SC 29631 +1-888-389-4485 ~6.27 miles east of Seneca
  • Four star hotel
  • 41 sleeping rooms in hotel
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Excellent 9.6 /10 Reviews Call BookMore Details
Hampton Inn Greenville I-385 - Woodruff Rd. 15 Park Woodruff Dr, Greenville, SC 296075728 +1-888-389-4121 ~38.73 miles east of Seneca
  • Affordable hotel
  • Check in time: 3:00 PM - 2:00 AM
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Very Good 8.8 /10 Latest Reviews Call BookMore Details
Hampton Inn Greer Greenville SC 112 North Main Street, Greer, SC 29650 +1-888-675-2083 ~44.90 miles east of Seneca
  • Affordable hotel
  • Check in: 3:00 PM - anytime
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Excellent 9.4 /10 Hotel Reviews Call BookMore Details
Residence Inn by Marriott Greenville-Spartanburg Airport 120 Milestone Way, Greenville, SC 296155065 +1-800-716-8490 ~40.69 miles east of Seneca
  • 3 star property
  • Hotel has 3 floors
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Very Good 8.6 /10 Reviews Call BookMore Details
The Inn at Patrick Square 115 Market Street, Clemson, SC 29631 +1-800-805-5223 ~9.46 miles east of Seneca
  • Affordable property
  • 45 rooms in property
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Excellent 9.8 /10 Read Reviews Call BookMore Details
Holiday Inn Express & Suites Greenville-I-85 & Woodruff Rd by IHG 1036 Woodruff Rd, Greenville, SC 29607 +1-888-965-1860 ~37.84 miles east of Seneca
  • 3-star property
  • Free complimentary breakfast
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Excellent 9.0 /10 Reviews Call BookMore Details
Hampton Inn Greenville / I-385 Haywood Mall 255 Congaree Road, Greenville, SC 29607 +1-888-788-5576 ~36.95 miles east of Seneca
  • 3 star property
  • Pets are Allowed
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Excellent 9.0 /10 Guest Reviews Call BookMore Details
Courtyard Marriott Clemson 201 Canoy Ln, Clemson, SC 296313160 +1-888-897-9207 ~7.99 miles east of Seneca
  • Affordable hotel
  • Hotel has 6 floors
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Excellent 9.0 /10 Review Score Call BookMore Details
Home2 Suites by Hilton Greenville Airport 20 Beacon Drive, Greenville, SC 29615 +1-888-311-4278 ~40.63 miles east of Seneca
  • Mid-scale property
  • 102 suites in property
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Excellent 9.2 /10 Recent Reviews Call BookMore Details
Hotel Hartness 120 Halston Avenue, Greenville, SC 29615 +1-888-469-4795 ~41.26 miles east of Seneca
  • 4 star hotel
  • Check-in: 3:00 PM - 2:00 AM
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Excellent 9.8 /10 Reviews Call BookMore Details
Hampton Inn & Suites Greenville Airport SC 128 The Parkway, Greenville, SC 29615 +1-888-734-9421 ~41.33 miles east of Seneca
  • Affordable hotel
  • Fitness / Gym is on-site
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Excellent 9.2 /10 Read Reviews Call BookMore Details
The Shepherd Hotel Downtown Clemson 110 Sloan St, Clemson, SC 29631 +1-888-841-5292 ~6.58 miles east of Seneca
  • Expensive hotel
  • Pet Friendly
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Excellent 9.8 /10 Read Reviews Call BookMore Details
Helendorf River Inn Suites & Conference Center 33 Munich Strasse, Helen, GA 30545 +1-888-455-5160 ~44.12 miles west of Seneca
  • 3-star property
  • 98 sleeping rooms in hotel
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Excellent 9.2 /10 Latest Reviews Call BookMore Details
Holiday Inn Express & Suites Greenville - Taylors by IHG 2025 Wade Hampton Blvd, Greenville, SC 29615 +1-888-965-8297 ~36.61 miles east of Seneca
  • Midscale property
  • Hotel has 25 rooms
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SureStay Hotel by Best Western Helen Downtown 8396 South Main St, Helen, GA 30545 +1-888-906-6358 ~44.04 miles west of Seneca
  • Three Star hotel
  • 57 rooms in hotel
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Very Good 8.3 /10 Latest Reviews Call BookMore Details
Holiday Inn Express & Suites Clemson by IHG 1381 Tiger Blvd, Clemson, SC 296311119 +1-888-749-6785 ~7.69 miles east of Seneca
  • Midscale hotel
  • Check in: 3:00 PM - anytime
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Very Good 8.8 /10 Review Score Call BookMore Details
Residence Inn by Marriott Anderson Clemson 109 INTERSTATE BLVD, Anderson, SC 29621 +1-888-878-9982 ~15.68 miles east of Seneca
  • 3 star property
  • 3 floors in property
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Excellent 9.5 /10 Recent Reviews Call BookMore Details

Next: See My Seneca Hotels with Pricing

When should you visit Seneca, SC?

To experience the city at its liveliest, don't miss Seneca Fest. This annual event takes place at the end of May and features a full lineup of musical performances, action-packed wrestling matches, and family-friendly activities.

To plan your trip around the area's best weather, consider visiting during the spring or fall when high temperatures usually top out in the low 80s or high 70s. Summers can get very hot in Seneca, with highs in the 90s, and winters can get chilly, with lows around 30. Although August tends to be the wettest month of the year, winter is rainy season in Seneca. If you visit during the winter, bundle up and wear a waterproof jacket to stay warm and dry.

Winter is low season in Seneca, and you're most likely to find great discounts on hotels in January or February. For low rates on accommodations during high season, start planning in advance, and look for group rates.

What hotels in Seneca, SC offer the best discounts?

Looking for the best deals and discounts on Seneca hotels? Browse some of the best group rates in the area.

Senior travelers and AARP members can get discounts at the Best Western Executive Inn in Seneca. This centrally located hotel has both suites and standard rooms, and you'll appreciate the outdoor pool and the complimentary breakfast served each morning.

AAA members can get low rates at the Baymont Inn & Suites in Anderson. This mid-range hotel has a long list of extras, including free breakfast, a fitness center, an outdoor pool, and a meeting room available for reservation.

Government employees and members of the military can save at the Rodeway Inn in nearby Anderson. This budget-friendly hotel has 50 affordable rooms with basics like mini-fridges, microwaves, and coffee makers, and the hotel offers easy access to Interstate 85.

Where are the hotels with the most value in Seneca, South Carolina

It's easy to balance price with amenities when you book one of the best value options in Seneca. Take a look at the area's best mid-range hotels.

When you want to stay in the heart of Seneca, the Quality Inn offers plenty of value in a convenient location. This mid-range hotel has over 60 well-equipped guest rooms, along with a fitness center, an outdoor pool, and free Wi-Fi. You'll love the signature Q Beds, and after a great night's sleep, you'll be ready to dig into the complimentary breakfast spread. This Quality Inn welcomes up to two pets per room, making it easy to travel with your furry family members.

Nestled in nearby Clemson, the Best Western Plus University Inn & Conference Center is a smart choice for both leisure and business travelers. Settle into your modern guest room, grab a bite to eat at the full-service restaurant, and catch up on work in the business center. This Best Western also has six available conference rooms and an average group discount of over 20 percent, making this mid-range hotel excellent for groups visiting the Seneca area.

Also located in Clemson, Comfort Inn Clemson SC (Clemson University & Seneca Area) features three meeting rooms and an average group discount of over 15 percent. This mid-range hotel has guest rooms equipped with microwaves, coffee makers, and mini-fridges as well as an outdoor pool that's ideal for cooling off on a hot summer day. In the morning, don't miss the free breakfast bar, which includes biscuits and gravy, fresh waffles, pastries, and coffee.

What can't-miss attractions should you see in Seneca, SC?

With its equal doses of historical charm and natural beauty, Seneca has a little something for every visitor. Take a stroll through the Seneca Historic District to enjoy this South Carolina gem's small-town appeal and marvel at the many homes and churches that date back to the 19th century.

Located in the heart of the Seneca Historic District, the Lunney House Museum is an essential stop for history buffs. A stunning example of the architecture that defined the New South in the early 20th century, this home features impressive details like a sparkling chandelier, an intricately carved oak mantel, a 19th-century grand piano, and art glass windows. Take a self-guided tour of the house museum or check the museum's calendar for special events.

To gain a more comprehensive picture of Seneca's history, you'll also want to visit the Bertha Lee Strickland Cultural Museum. This fascinating museum explores the history of African-American culture and Oconee County residents through a variety of permanent and temporary exhibitions.

If you're traveling with kids in tow, you'll also want to visit the World of Energy at Oconee Nuclear. This interactive museum is a fun place for kids of all ages to learn about electricity, energy, and local nature and wildlife.

Next, experience Seneca's natural beauty firsthand with a visit to South Cove County Park. Located on the shores of Lake Keowee, this park is perfect for swimming, sunbathing, boating, and fishing. You can also take advantage of the tennis courts, picnic areas, and playgrounds all year round. If you didn't bring your own boat, you'll find canoe, kayak, and pontoon boat rentals at Lake Keowee Marina and many other local spots.

Why wait to book your trip? Find the ideal place to stay and start designing your Seneca itinerary.

What did travelers think of the city of Seneca?

Below are reviews of the city of Seneca, SC from an actual visitor's perspective.

"Easy to get around"
Score 4.0 / 5

Michelle W., from 11-Oct-2026
"Plenty of places to eat and more coming"
Score 4.0 / 5

Micheal C., from 09-Oct-2026
"I reside in the area"
Score 5.0 / 5

John A., from 18-Sep-2026
"Worked For Me"
Score 5.0 / 5

I live in Seneca, I needed to vacate my house due to a pest control treatment for one night

Richard H., from 01-Nov-2025
"Great Restaurants"
Score 5.0 / 5

Great restaurants

Lauren F., from 07-Oct-2025
"Beautiful town with lots to offer."
Score 5.0 / 5

Beautiful town with lots to offer.

Jessica D., from 12-Jul-2025
"Great Location!"
Score 4.0 / 5

Seneca has a little bit of everything that larger cities have with the small town feel.

Tara L., from 22-Jun-2025
"Beautiful Area and Excellent Cherokee Museum"
Score 5.0 / 5

The Cherokee Museum in Walhalla. Excellent! And the landscape and look of the hills and lush vegetation in the county. Who knew about all the water, waterfalls, great hikes.

Delia O., from 27-Apr-2025
"Loved it!"
Score 5.0 / 5

I loved it!

Vivian B., from 18-Mar-2025
"Good Location"
Score 5.0 / 5

Good location.

Sylvia M., from 10-Feb-2025
"The View!"
Score 4.0 / 5

The view!

Tammy S., from 25-Jun-2024
"Beautiful Water Views!"
Score 5.0 / 5

Beautiful views of water!

Tammy S., from 25-Jun-2024
"Convenient to Shops & Restaurants"
Score 5.0 / 5

The shops and restaurants being close to the hotel was very convenient.

Kristin M., from 23-Jun-2024
"Nostalgic Drive-In and Jazz"
Score 5.0 / 5

We were given a recommendation for a great burger joint. Time Drive-In! Suggest y'all check it out. It was a throw back to when burgers were good and service meant something! Seneca is a fun town to walk in the downtown area, lots to see. Thursday night jazz was fun.

Kelly J., from 16-Jun-2024
"Nice City"
Score 5.0 / 5

It's a nice city.

Richard S., from 17-Dec-2023
"Nice town and great restaurant!"
Score 5.0 / 5

Nice and clean little town and a great restaurant, Seneca family restaurant.

Warren C., from 14-Oct-2023
"Good Location"
Score 5.0 / 5

The hotel was easy to find.

Dwight H., from 29-Sep-2023
"Great Places to Eat!"
Score 4.0 / 5

Friendly people and great places to eat. Example, Blue Marble Deli and Tipsy Taco.

Andrew S., from 14-May-2023
"Very Pretty Area"
Score 5.0 / 5

Very pretty area!

Debora L., from 15-Apr-2023
"Nice Place & Good Restaurants"
Score 5.0 / 5

Nice place to visit. Good restaurants.

Barry P., from 27-Mar-2023
"Nice Small Town "
Score 5.0 / 5

Seneca is a very nice small town. It has what you need for a short visit.

Jerry A., from 21-Mar-2023
"Nice Place"
Score 4.0 / 5

Nice place and good place to visit.

Peter B., from 15-Oct-2022
"Central to Lake Hartwell, Lake Jocassee & Lake Keowee"
Score 4.0 / 5

The main reason I like Seneca is the city's central proximity to Lake Hartwell, Lake Jocassee, and Lake Keowee.

John M., from 26-Jun-2022
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