Hotels in 77221 - Houston TX

Only hotels in 77221 zip code are listed below. Search for cheap and discount hotel rates in Houston, TX for your upcoming leisure or conference / group travel. We list the best 77221 hotels and motels so you can review the Houston hotel list below to find the perfect lodging. Hotels in Harris county and area code 713 are also listed.

77221 Hotels/Motels & Accommodations

Cliù Luxury Boutique Condo Hotel in Houston 3144 Southmore Blvd. Unit 10, Houston, TX 77004 Call ~1.13 miles northwest of 77221
  • 4 star Downtown hotel
  • Check-in: 4:00pm CST
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From$120 total
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Extended Stay America Suites Houston Med Ctr Greenway Plaza : 2330 Southwest Frwy 2330 Southwest Frwy, Houston, TX 77098 Call ~1.16 miles west of 77221
  • 2-star Downtown hotel
  • Access to gym on-site
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From$73 total
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Summit Inn - Houston Medical Center 3138 Old Spanish Trail, Houston, TX 77054 Call ~1.37 miles west of 77221
  • Low-priced property
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From$72 total
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Mainstay Suites Texas Medical Center / Reliant Park - Houston 3134 Old Spanish Trail, Houston, TX 77054 Call ~1.41 miles west of 77221
  • Inexpensive Convention Center hotel
  • Gym is available on property
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From$72 total
Very good 4.0 /5 Read Reviews Call BookMore Details
Hilton University of Houston : 4800 Calhoun Rd. 4800 Calhoun Rd., Houston, TX 77004 Call ~1.54 miles northeast of 77221
  • High-end Downtown hotel
  • 86 rooms in hotel
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From$150 total
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Americas Best Value Inn Medical Center Downtown in Houston 2419 Riverside Dr., Houston, TX 77004 Call ~1.64 miles northwest of 77221
  • Two star hotel
  • 2 floors in property
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From$72 total
Very good 4.0 /5 Reviews Call BookMore Details
Home2 Suites - Houston 6840 Almeda Rd., Houston, TX 77030 Call ~1.81 miles west of 77221
  • Midscale Suburban property
  • Free comp. breakfast
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From$118 total
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Hilton Garden Inn 6840b Almeda Rd., Houston, TX 77030 Call ~1.81 miles west of 77221
  • 3-star Suburban hotel
  • 36 suites in property
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From$130 total
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Hilton Garden 6840 B Almeda Rd., Houston, TX 77030 Call ~1.82 miles west of 77221
  • Three Star hotel
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From$96 total
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Medical District - Houston 2700 Old Spanish Trail, Houston, TX 77021 Call ~1.92 miles west of 77221
  • 4 star property
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From$90 total
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Sonder The Hampstead - Houston 1508 Blodgett, Houston, TX 77004 Call ~2.32 miles northwest of 77221
  • Affordable Downtown property
  • 36 sleeping rooms in hotel
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From$96 total
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Scott Inn Suites Downtown Houston 1933 Scott St., Houston, TX 77003 Call ~2.34 miles north of 77221
  • Midscale property
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From$108 total
Very good 4.0 /5 Read Reviews Call BookMore Details
Best Way Inn Houston - Medical Center in Houston 3100 Holmes Rd., Houston, TX 77051 Call ~2.49 miles southwest of 77221
  • Cheap property
  • Hotel has 42 rooms
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From$72 total
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Extended Stay America Suites Houston Med Ctr Braeswood Bl 1301 Braeswood Blvd., Houston, TX 77030 Call ~2.52 miles west of 77221
  • 3-star Convention Center hotel
  • Check-in: 3:00pm
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From$76 total
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Hotel Zaza Houston Museum District - Houston 5701 Main St., Houston, TX 77005 Call ~2.57 miles northwest of 77221
  • Expensive Downtown hotel
  • 12 floors in hotel
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From$190 total
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Blossom Houston Medical Center 7114 Bertner Ave., Houston, TX 77030 Call ~2.68 miles west of 77221
  • 3 star hotel
  • Hotel has 230 rooms
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From$108 total
Very good 4.0 /5 Review Score Call BookMore Details
Blossom Hotel Houston 7118 Bertner Ave., Houston, TX 77030 Call ~2.68 miles west of 77221
  • 4 star Convention Center property
  • 12 meeting rooms in hotel
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From$202 total
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Days Inn & Suites by Wyndham Downtown / University of Houston : 6190 Gulf Freeway 6190 Gulf Freeway, Houston, TX 77023 Call ~2.72 miles east of 77221
  • 3 star Downtown hotel
  • Check in time: 2:00pm
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From$66 total
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Lexington Hotel Houston Medical Center in Houston 1025 Swanson St., Houston, TX 77030 Call ~2.78 miles west of 77221
  • Two star Downtown property
  • Check in: 3:00 PM
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From$72 total
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Hyatt Place : 7329a Fannin St. 7329a Fannin St., Houston, TX 77030 Call ~2.78 miles west of 77221
  • 3-star property
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From$96 total
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Hyatt Place Hyatt House Houston Medical Center - Houston 7329 Fannin St., Houston, TX 77030 Call ~2.78 miles west of 77221
  • 3 star Suburban hotel
  • Check-in time: 3PM
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From$118 total
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Houston Marriott Medical Center/Museum District 6580 Fannin St., Houston, TX 77030 Call ~2.80 miles west of 77221
  • High end Downtown hotel
  • Access to gym on-site
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From$90 total
Very good 4.5 /5 Recent Reviews Call BookMore Details
The Westin Hou Medical Center - Houston 1709 Dryden Rd., Houston, TX 77030 Call ~2.81 miles west of 77221
  • Mid-scale property
  • Check-in: 15:00
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From$108 total
Very good 4.0 /5 Recent Reviews Call BookMore Details
Sonder at Mid Main 3550 Main St., Houston, TX 77002 Call ~2.86 miles northwest of 77221
  • Midscale Downtown hotel
  • Check-in time: 4:00 pm
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From$90 total
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Hampton Inn & Suites Houston Medical Center Nrg Park 1715 Old Spanish Trail, Houston, TX 77054 Call ~2.91 miles west of 77221
  • Three Star Convention Center property
  • Check in time: 3:00PM
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From$82 total
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Houston Medical Center Hotel 6700 Main St., Houston, TX 77030 Call ~2.94 miles west of 77221
  • 3 star Downtown hotel
  • 25 suites in hotel
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From$138 total
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InterContinental Houston by IHG in Houston 6750 Main St., Houston, TX 77030 Call ~2.98 miles west of 77221
  • Expensive Downtown property
  • Check-in: 15:00
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From$90 total
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Doubletree by Hilton Houston Medical Center Hotel & Suites - Houston 6800 Main St., Houston, TX 77030 Call ~3.01 miles west of 77221
  • High-end Downtown property
  • Gym / Fitness Center Available
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From$150 total
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Extended Stay America - Houston - Med Ctr-NRG Park-Fannin in Houston 7979 Fannin, Houston, TX 77054 Call ~3.01 miles west of 77221
  • Low Cost Convention Center property
  • 153 rooms in hotel
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From$58 total
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Best Western Premier Houston Downtown/Convention Center Hotel in Houston 1810 Bell St., Houston, TX 77003 Call ~3.12 miles north of 77221
  • Affordable Downtown hotel
  • Hotel has an eco-friendly policy See policy
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From$96 total
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Wanderstay Boutique Hotel 520 Sampson St., Houston, TX 77003 Call ~3.15 miles north of 77221
  • High-end hotel
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From$150 total
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SpringHill Suites Houston Medical Center/NRG Park 1400 Old Spanish Trl, Houston, TX 77054 Call ~3.32 miles west of 77221
  • Midscale Downtown hotel
  • 190 suites in hotel
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From$96 total
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Whyhotel Houston Downtown : 1515 Austin St. 1515 Austin St., Houston, TX 77002 Call ~3.33 miles north of 77221
  • 3-star hotel
  • Check in time: 15:00
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From$108 total
Very good 4.0 /5 Guest Reviews Call BookMore Details
Athens Hotel Suites in Houston 1308 Clay St., Houston, TX 77002 Call ~3.39 miles north of 77221
  • Midscale Downtown hotel
  • 21 sleeping rooms in hotel
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From$106 total
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La Colombe D Or Hotel : 3410 Montrose Blvd. 3410 Montrose Blvd., Houston, TX 77006 Call ~3.40 miles northwest of 77221
  • 3 star property
  • 2 floors in property
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From$108 total
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Hilton Americas Houston 1600 Lamar St., Houston, TX 77010 Call ~3.40 miles north of 77221
  • High end Downtown property
  • 27 meeting rooms in hotel
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From$121 total
Very good 4.5 /5 Recent Reviews Call BookMore Details
Hotel Saint Augustine 4110 Loretto Dr., Houston, TX 77006 Call ~3.41 miles northwest of 77221
  • 4-star Downtown hotel
  • 2 floors in hotel
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From$481 total
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Embassy Suites Houston Downtown - Houston 1515 Dallas St., Houston, TX 77002 Call ~3.42 miles north of 77221
  • Mid-scale Downtown hotel
  • 262 sleeping rooms in hotel
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From$238 total
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Embassy Suites Houston Downtown 1515 Dallas, Houston, TX 77010 Call ~3.42 miles north of 77221
  • Three Star Downtown property
  • Gym / Fitness Center Available
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From$162 total
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Sonder Midtown 306 Mcgowen St., Houston, TX 77006 Call ~3.44 miles northwest of 77221
  • Three Star Downtown property
  • Access to gym on-site
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From$90 total
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Holiday Inn Houston Downtown by IHG in Houston 1616 Main St., Houston, TX 77002 Call ~3.46 miles north of 77221
  • Affordable Downtown property
  • Hotel has 213 rooms
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From$94 total
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Marriott Marquis Houston 1777 Walker St., Houston, TX 77010 Call ~3.46 miles north of 77221
  • High end hotel
  • 40 suites in hotel
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From$450 total
Very good 4.0 /5 Recent Reviews Call BookMore Details
Courtyard by Marriott Houston Medical Center/NRG Park Houston Medical Center 7702 Main St., Houston, TX 77030 Call ~3.47 miles west of 77221
  • Affordable Suburban property
  • Check in time: 3:00 PM
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From$82 total
Very good 4.0 /5 Reviews Call BookMore Details
Sonder Lofts at Ballpark in Houston 610 St. Emanuel St. Houston Tx 77003, Houston, TX 77003 Call ~3.47 miles north of 77221
  • Mid-scale Downtown hotel
  • Hotel has 22 rooms
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From$120 total
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The Reside 7755 South Main St., Houston, TX 77054 Call ~3.50 miles west of 77221
  • Affordable Downtown hotel
  • 36 suites in hotel
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From$66 total
Very good 4.0 /5 Recent Reviews Call BookMore Details
Holiday Inn Houston S - Nrg Area - Medical Center by IHG 8111 Kirby Dr., Houston, TX 77054 Call ~3.50 miles west of 77221
  • 3 star Suburban property
  • 6 suites in property
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From$151 total
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Four Seasons Hotel Houston in Houston 1300 Lamar St., Houston, TX 77010 Call ~3.51 miles north of 77221
  • Luxury 5 star Downtown property
  • 12 meeting rooms in hotel
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From$330 total
Very good 4.0 /5 Recent Reviews Call BookMore Details
Extended Stay America Suites Houston Med Ctr NRG Park Kirby 1303 La Concha Ln, Houston, TX 77054 Call ~3.52 miles west of 77221
  • Low Cost Convention Center property
  • 3 floors in hotel
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From$49 total
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Courtyard Houston Medical Center / Nrg Park - Houston 7702 Main St., Houston, TX 77030 Call ~3.55 miles west of 77221
  • Mid-scale Downtown property
  • 3 meeting rooms in hotel
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From$96 total
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Bayou City Event Center 9401 Knight Rd., Houston, TX 77045 Call ~3.55 miles southwest of 77221
  • Cheap property
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From$72 total
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