Hotels in 77221 - Houston TX

Only hotels in 77221 zip code are listed below. Search for cheap and discount hotel rates in Houston, TX for your upcoming leisure or conference / group travel. We list the best 77221 hotels and motels so you can review the Houston hotel list below to find the perfect lodging. Hotels in Harris county and area code 713 are also listed.

77221 Hotels/Motels & Accommodations

Cliù Luxury Boutique Condo Hotel : 3144 Southmore Blvd. Unit 10 3144 Southmore Blvd. Unit 10, Houston, TX 77004 Call ~1.13 miles northwest of 77221
  • High end Downtown property
  • 16 rooms in property
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Extended Stay America Suites Houston Med Ctr Greenway Plaza - Houston 2330 Southwest Frwy, Houston, TX 77098 Call ~1.16 miles west of 77221
  • Cheap Downtown property
  • 3 floors in property
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From$61
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Summit Inn - Houston Medical Center in Houston 3138 Old Spanish Trail, Houston, TX 77054 Call ~1.37 miles west of 77221
  • Two-star hotel
  • Hotel has 33 rooms
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From$60
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Mainstay Suites Texas Medical Center / Reliant Park 3134 Old Spanish Trail, Houston, TX 77054 Call ~1.41 miles west of 77221
  • Inexpensive Convention Center hotel
  • Access to gym on-site
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From$60
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Hilton University of Houston 4800 Calhoun Rd., Houston, TX 77004 Call ~1.54 miles northeast of 77221
  • 4-star Downtown hotel
  • 8 floors in hotel
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From$125
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Americas Best Value Inn Medical Center Downtown 2419 Riverside Dr., Houston, TX 77004 Call ~1.64 miles northwest of 77221
  • Cheap property
  • Comp. Breakfast
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From$60
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Home2 Suites in Houston 6840 Almeda Rd., Houston, TX 77030 Call ~1.81 miles west of 77221
  • 3 star Suburban property
  • Complimentary breakfast is offered
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From$99
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Hilton Garden Inn - Houston 6840b Almeda Rd., Houston, TX 77030 Call ~1.81 miles west of 77221
  • 3 star Suburban property
  • Fitness center on property
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From$109
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Hilton Garden : 6840 B Almeda Rd. 6840 B Almeda Rd., Houston, TX 77030 Call ~1.82 miles west of 77221
  • Three Star hotel
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From$80
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Medical District : 2700 Old Spanish Trail 2700 Old Spanish Trail, Houston, TX 77021 Call ~1.92 miles west of 77221
  • Expensive hotel
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Sonder The Hampstead 1508 Blodgett, Houston, TX 77004 Call ~2.32 miles northwest of 77221
  • Three Star Downtown property
  • Hotel has 36 rooms
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From$80
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Scott Inn Suites Downtown Houston 1933 Scott St., Houston, TX 77003 Call ~2.34 miles north of 77221
  • Midscale property
  • 2 floors in hotel
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From$90
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Best Way Inn Houston - Medical Center 3100 Holmes Rd., Houston, TX 77051 Call ~2.49 miles southwest of 77221
  • Two-star property
  • Check in time: 13:00
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Extended Stay America Suites Houston Med Ctr Braeswood Bl 1301 Braeswood Blvd., Houston, TX 77030 Call ~2.52 miles west of 77221
  • 3 star Convention Center property
  • Hotel has 3 floors
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From$64
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Hotel Zaza Houston Museum District 5701 Main St., Houston, TX 77005 Call ~2.57 miles northwest of 77221
  • 4-star Downtown property
  • 75 suites in property
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From$159
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Blossom Houston Medical Center 7114 Bertner Ave., Houston, TX 77030 Call ~2.68 miles west of 77221
  • Three Star property
  • Check in time: 16:00
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From$90
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Blossom Hotel Houston in Houston 7118 Bertner Ave., Houston, TX 77030 Call ~2.68 miles west of 77221
  • Four star Convention Center hotel
  • 37 suites in property
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Days Inn & Suites by Wyndham Downtown / University of Houston : 6190 Gulf Freeway 6190 Gulf Freeway, Houston, TX 77023 Call ~2.72 miles east of 77221
  • Three Star Downtown hotel
  • Check-in: 2:00pm
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Lexington Hotel Houston Medical Center in Houston 1025 Swanson St., Houston, TX 77030 Call ~2.78 miles west of 77221
  • Low-priced Downtown hotel
  • Gym is available on property
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Hyatt Place in Houston 7329a Fannin St., Houston, TX 77030 Call ~2.78 miles west of 77221
  • 3 star property
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From$80
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Hyatt Place Hyatt House Houston Medical Center : 7329 Fannin St. 7329 Fannin St., Houston, TX 77030 Call ~2.78 miles west of 77221
  • 3 star Suburban property
  • 14 floors in hotel
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Houston Marriott Medical Center/Museum District : 6580 Fannin St. 6580 Fannin St., Houston, TX 77030 Call ~2.80 miles west of 77221
  • 4-star Downtown hotel
  • Hotel has 14 meeting rooms
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The Westin Hou Medical Center - Houston 1709 Dryden Rd., Houston, TX 77030 Call ~2.81 miles west of 77221
  • Affordable property
  • Check in: 15:00
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Sonder at Mid Main - Houston 3550 Main St., Houston, TX 77002 Call ~2.86 miles northwest of 77221
  • Three Star Downtown hotel
  • 4 floors in hotel
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Hampton Inn & Suites Houston Medical Center Nrg Park 1715 Old Spanish Trail, Houston, TX 77054 Call ~2.91 miles west of 77221
  • Three Star Convention Center hotel
  • Check in time: 3:00PM
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From$69
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Houston Medical Center Hotel 6700 Main St., Houston, TX 77030 Call ~2.94 miles west of 77221
  • Midscale Downtown property
  • Check-in: 03:00
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From$115
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InterContinental Houston by IHG : 6750 Main St. 6750 Main St., Houston, TX 77030 Call ~2.98 miles west of 77221
  • Expensive Downtown hotel
  • 21 floors in hotel
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Doubletree by Hilton Houston Medical Center Hotel & Suites 6800 Main St., Houston, TX 77030 Call ~3.01 miles west of 77221
  • Four-star Downtown property
  • Hotel has 297 rooms
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Extended Stay America - Houston - Med Ctr-NRG Park-Fannin - Houston 7979 Fannin, Houston, TX 77054 Call ~3.01 miles west of 77221
  • Economy Convention Center property
  • Hotel has 12 suites
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Holiday Inn Express Houston Downtown 1810 Bell St., Houston, TX 77003 Call ~3.10 miles north of 77221
  • Mid-scale Downtown hotel
  • 112 rooms in hotel
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Wanderstay Boutique Hotel in Houston 520 Sampson St., Houston, TX 77003 Call ~3.15 miles north of 77221
  • 4 star hotel
  • Check-in time: 2:00PM CST
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SpringHill Suites Houston Medical Center/NRG Park - Houston 1400 Old Spanish Trl, Houston, TX 77054 Call ~3.32 miles west of 77221
  • Midscale Downtown hotel
  • Check-in time: 3.00 pm
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Whyhotel Houston Downtown 1515 Austin St., Houston, TX 77002 Call ~3.33 miles north of 77221
  • Midscale property
  • 103 rooms in property
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Athens Hotel Suites : 1308 Clay St. 1308 Clay St., Houston, TX 77002 Call ~3.39 miles north of 77221
  • Mid-scale Downtown hotel
  • 21 sleeping rooms in hotel
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La Colombe D Or Hotel in Houston 3410 Montrose Blvd., Houston, TX 77006 Call ~3.40 miles northwest of 77221
  • Three Star property
  • Check-in time: 16:00
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Hilton Americas Houston - Houston 1600 Lamar St., Houston, TX 77010 Call ~3.40 miles north of 77221
  • High end Downtown property
  • 24 floors in hotel
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Hotel Saint Augustine : 4110 Loretto Dr. 4110 Loretto Dr., Houston, TX 77006 Call ~3.41 miles northwest of 77221
  • Expensive Downtown property
  • 2 floors in property
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From$401
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Embassy Suites Houston Downtown 1515 Dallas, Houston, TX 77010 Call ~3.42 miles north of 77221
  • Affordable Downtown property
  • Hotel has 262 suites
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From$135
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Sonder Midtown - Houston 306 Mcgowen St., Houston, TX 77006 Call ~3.44 miles northwest of 77221
  • Affordable Downtown hotel
  • 6 floors in hotel
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Holiday Inn Houston Downtown by IHG 1616 Main St., Houston, TX 77002 Call ~3.46 miles north of 77221
  • 3-star Downtown property
  • 20 suites in property
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Marriott Marquis Houston : 1777 Walker St. 1777 Walker St., Houston, TX 77010 Call ~3.46 miles north of 77221
  • Four star property
  • Hotel has 29 floors
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From$375
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Courtyard by Marriott Houston Medical Center/NRG Park in Houston Houston Medical Center 7702 Main St., Houston, TX 77030 Call ~3.47 miles west of 77221
  • Affordable Suburban hotel
  • Check in: 3:00 PM
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From$69
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Sonder Lofts at Ballpark in Houston 610 St. Emanuel St. Houston Tx 77003, Houston, TX 77003 Call ~3.47 miles north of 77221
  • 3-star Downtown hotel
  • Check in time: 4:00 PM
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The Reside 7755 South Main St., Houston, TX 77054 Call ~3.50 miles west of 77221
  • Three Star Downtown hotel
  • 36 rooms in property
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Holiday Inn Houston S - Nrg Area - Medical Center by IHG - Houston 8111 Kirby Dr., Houston, TX 77054 Call ~3.50 miles west of 77221
  • 3 star Suburban property
  • 6 suites in property
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Four Seasons Hotel Houston 1300 Lamar St., Houston, TX 77010 Call ~3.51 miles north of 77221
  • Luxury Five Star Downtown property
  • 115 suites in hotel
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From$275
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Extended Stay America Suites Houston Med Ctr NRG Park Kirby 1303 La Concha Ln, Houston, TX 77054 Call ~3.52 miles west of 77221
  • 2-star Convention Center property
  • Check in: 3pm
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From$41
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Courtyard Houston Medical Center / Nrg Park 7702 Main St., Houston, TX 77030 Call ~3.55 miles west of 77221
  • Mid-scale Downtown property
  • Fitness + Health Center
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Bayou City Event Center - Houston 9401 Knight Rd., Houston, TX 77045 Call ~3.55 miles southwest of 77221
  • Low Cost hotel
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From$60
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Residence Inn Houston Medical Center / Nrg Park 7807 Kirby Dr., Houston, TX 77030 Call ~3.56 miles west of 77221
  • Affordable Downtown hotel
  • Hotel has 182 suites
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From$109
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