Hotels in 77221 - Houston TX

Only hotels in 77221 zip code are listed below. Search for cheap and discount hotel rates in Houston, TX for your upcoming leisure or conference / group travel. We list the best 77221 hotels and motels so you can review the Houston hotel list below to find the perfect lodging. Hotels in Harris county and area code 713 are also listed.

77221 Hotels & Accommodations

Cliù Luxury Boutique Condo Hotel - Houston
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
3144 Southmore Blvd. Unit 10, Houston, TX 77004 +1-888-389-4121 ~1.13 miles northwest of 77221
  • 4-star Downtown hotel
  • Check in time: 4:00pm CST
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From$100
Average 3.0 /5 Guest Reviews Call BookMore Details
Extended Stay America Suites Houston Med Ctr Greenway Plaza : 2330 Southwest Frwy
+1-888-675-2083

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New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
2330 Southwest Frwy, Houston, TX 77098 +1-888-675-2083 ~1.17 miles west of 77221
  • Two-star Downtown hotel
  • Free breakfast
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From$61
Average 3.0 /5 Latest Reviews Call BookMore Details
Summit Inn - Houston Medical Center
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
3138 Old Spanish Trail, Houston, TX 77054 +1-800-716-8490 ~1.37 miles west of 77221
  • Low priced property
  • Check in time: 11:00
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From$60
Average 3.0 /5 Recent Reviews Call BookMore Details
Mainstay Suites Medical Center / Reliant Park - Houston
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
3134 Old Spanish Trail, Houston, TX 77054 +1-800-805-5223 ~1.41 miles west of 77221
  • Cheap Convention Center property
  • 89 rooms in hotel
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From$60
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Hilton University of Houston - Houston
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
4800 Calhoun Rd., Houston, TX 77004 +1-888-965-1860 ~1.54 miles northeast of 77221
  • High-end Downtown property
  • Hotel has 12 suites
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From$125
Average 3.0 /5 Recent Reviews Call BookMore Details
Americas Best Value Inn Medical Center Downtown
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
2419 Riverside Dr., Houston, TX 77004 +1-888-788-5576 ~1.65 miles northwest of 77221
  • Economical property
  • Complimentary breakfast is offered
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From$60
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Home2 Suites
+1-888-897-9207

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New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
6840 Almeda Rd., Houston, TX 77030 +1-888-897-9207 ~1.82 miles west of 77221
  • Midscale Suburban hotel
  • Check-in: 3:00 PM
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From$99
Excellent 5.0 /5 Hotel Reviews Call BookMore Details
Hilton Garden Inn
+1-888-311-4278

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New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
6840b Almeda Rd., Houston, TX 77030 +1-888-311-4278 ~1.82 miles west of 77221
  • Affordable Suburban hotel
  • Check in: 3:00 PM
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From$109
Average 3.0 /5 Recent Reviews Call BookMore Details
Hilton Garden
+1-888-469-4795

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New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
6840 B Almeda Rd., Houston, TX 77030 +1-888-469-4795 ~1.82 miles west of 77221
  • Three Star property
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From$80
Average 3.0 /5 Hotel Reviews Call BookMore Details
Medical District
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
2700 Old Spanish Trail, Houston, TX 77021 +1-888-734-9421 ~1.92 miles west of 77221
  • Expensive property
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From$75
Average 3.0 /5 Reviews Call BookMore Details
Sonder The Hampstead in Houston
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
1508 Blodgett, Houston, TX 77004 +1-888-841-5292 ~2.33 miles northwest of 77221
  • 3-star Downtown property
  • 36 rooms in hotel
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From$80
Average 3.0 /5 Recent Reviews Call BookMore Details
Scott Inn Suites Downtown Houston
+1-888-455-5160

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New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
1933 Scott St., Houston, TX 77003 +1-888-455-5160 ~2.34 miles north of 77221
  • Mid-scale hotel
  • 18 rooms in hotel
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From$90
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Best Way Inn Houston - Medical Center - Houston
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
3100 Holmes Rd., Houston, TX 77051 +1-888-965-8297 ~2.49 miles southwest of 77221
  • Cheap property
  • Check-in time: 13:00
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From$60
Average 3.0 /5 Hotel Reviews Call BookMore Details
Extended Stay America Suites Houston Med Ctr Braeswood Bl
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
1301 Braeswood Blvd., Houston, TX 77030 +1-888-906-6358 ~2.52 miles west of 77221
  • Mid-scale Convention Center property
  • Hotel has 4 suites
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From$64
Average 3.0 /5 Guest Reviews Call BookMore Details
Hotel Zaza Houston Museum District
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
5701 Main St., Houston, TX 77005 +1-888-749-6785 ~2.57 miles northwest of 77221
  • 4-star Downtown hotel
  • Gym is available on property
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From$159
Very Good 4.5 /5 Latest Reviews Call BookMore Details
Blossom Houston Medical Center - Houston
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
7114 Bertner Ave., Houston, TX 77030 +1-888-878-9982 ~2.68 miles west of 77221
  • 3-star hotel
  • Check-in time: 16:00
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From$90
Very Good 4.0 /5 Read Reviews Call BookMore Details
Blossom Hotel Houston : 7118 Bertner Ave.
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
7118 Bertner Ave., Houston, TX 77030 +1-888-389-4485 ~2.69 miles west of 77221
  • Expensive Convention Center hotel
  • 267 rooms in hotel
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From$99
Average 3.0 /5 Guest Reviews Call BookMore Details
Days Inn & Suites by Wyndham Downtown / University of Houston in Houston
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
6190 Gulf Freeway, Houston, TX 77023 +1-888-389-4121 ~2.73 miles east of 77221
  • 3-star Downtown hotel
  • Check-in: 2:00pm
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From$55
Average 3.0 /5 Guest Reviews Call BookMore Details
Lexington Hotel Houston Medical Center
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
1025 Swanson St., Houston, TX 77030 +1-888-675-2083 ~2.78 miles west of 77221
  • Cheap Downtown hotel
  • Fitness + Health Center
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From$60
Average 3.5 /5 Hotel Reviews Call BookMore Details
Hyatt Place - Houston
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
7329a Fannin St., Houston, TX 77030 +1-800-716-8490 ~2.79 miles west of 77221
  • 3-star hotel
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From$80
Average 3.0 /5 Review Score Call BookMore Details
Hyatt Place Hyatt House Houston Medical Center
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
7329 Fannin St., Houston, TX 77030 +1-800-805-5223 ~2.79 miles west of 77221
  • Affordable Suburban hotel
  • Comp. Breakfast
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From$99
Average 3.0 /5 Recent Reviews Call BookMore Details
Houston Marriott Medical Center/Museum District in Houston
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
6580 Fannin St., Houston, TX 77030 +1-888-965-1860 ~2.80 miles west of 77221
  • Four-star Downtown property
  • Hotel has 386 rooms
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From$75
Very Good 4.5 /5 Guest Reviews Call BookMore Details
The Westin Hou Medical Center : 1709 Dryden Rd.
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
1709 Dryden Rd., Houston, TX 77030 +1-888-788-5576 ~2.81 miles west of 77221
  • Midscale hotel
  • Fitness center on property
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From$90
Very Good 4.0 /5 Read Reviews Call BookMore Details
Sonder at Mid Main
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
3550 Main St., Houston, TX 77002 +1-888-897-9207 ~2.87 miles northwest of 77221
  • 3-star Downtown hotel
  • Check in: 4:00 pm
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From$75
Average 3.0 /5 Latest Reviews Call BookMore Details
Hampton Inn & Suites Houston Medical Center Nrg Park
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
1715 Old Spanish Trail, Houston, TX 77054 +1-888-311-4278 ~2.92 miles west of 77221
  • Affordable Convention Center hotel
  • 120 rooms in property
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From$69
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Houston Medical Center Hotel : 6700 Main St.
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
6700 Main St., Houston, TX 77030 +1-888-469-4795 ~2.94 miles west of 77221
  • Midscale Downtown property
  • 25 suites in hotel
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From$115
Average 3.5 /5 Read Reviews Call BookMore Details
InterContinental Houston by IHG - Houston
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
6750 Main St., Houston, TX 77030 +1-888-734-9421 ~2.98 miles west of 77221
  • Expensive Downtown hotel
  • Access to gym on-site
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From$75
Average 3.0 /5 Hotel Reviews Call BookMore Details
Doubletree by Hilton Houston Medical Center Hotel & Suites
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
6800 Main St., Houston, TX 77030 +1-888-841-5292 ~3.01 miles west of 77221
  • Three Star Downtown property
  • 10 floors in property
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From$80
Average 3.0 /5 Read Reviews Call BookMore Details
Extended Stay America - Houston - Med Ctr-NRG Park-Fannin in Houston
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
7979 Fannin, Houston, TX 77054 +1-888-455-5160 ~3.02 miles west of 77221
  • Low-priced Convention Center hotel
  • Hotel has 12 suites
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From$49
Poor 2.5 /5 Read Reviews Call BookMore Details
Holiday Inn Express Hotel & Suites Houston-Downtown Conv Ctr by I : 1810 Bell St.
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
1810 Bell St., Houston, TX 77003 +1-888-965-8297 ~3.11 miles north of 77221
  • 3 star Downtown hotel
  • Gym is available on property
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From$108
Very Good 4.0 /5 Review Score Call BookMore Details
Wanderstay Boutique Hotel : 520 Sampson St.
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
520 Sampson St., Houston, TX 77003 +1-888-906-6358 ~3.16 miles north of 77221
  • Expensive property
  • Check-in: 2:00PM CST
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From$125
Average 3.0 /5 Review Score Call BookMore Details
Springhill Suites Marriott Medical Center Nrg Park in Houston
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
1400 Old Spanish Trl, Houston, TX 77054 +1-888-749-6785 ~3.33 miles west of 77221
  • Mid-scale Downtown property
  • Check-in time: 3.00 pm
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From$80
Average 3.0 /5 Review Score Call BookMore Details
Whyhotel Houston Downtown in Houston
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
1515 Austin St., Houston, TX 77002 +1-888-878-9982 ~3.33 miles north of 77221
  • Three Star hotel
  • Check-in time: 15:00
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From$90
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Athens Hotel Suites in Houston
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
1308 Clay St., Houston, TX 77002 +1-888-389-4485 ~3.39 miles north of 77221
  • Affordable Downtown property
  • 2 floors in property
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From$89
Average 3.0 /5 Recent Reviews Call BookMore Details
La Colombe D Or Hotel : 3410 Montrose Blvd.
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
3410 Montrose Blvd., Houston, TX 77006 +1-888-389-4121 ~3.41 miles northwest of 77221
  • 3-star hotel
  • Check in time: 16:00
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From$90
Average 3.0 /5 Read Reviews Call BookMore Details
Hilton Americas Houston : 1600 Lamar St.
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
1600 Lamar St., Houston, TX 77010 +1-888-675-2083 ~3.41 miles north of 77221
  • 4-star Downtown property
  • 27 meeting rooms in property
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From$101
Very Good 4.5 /5 Recent Reviews Call BookMore Details
Hotel Saint Augustine : 4110 Loretto Dr.
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
4110 Loretto Dr., Houston, TX 77006 +1-800-716-8490 ~3.41 miles northwest of 77221
  • High-end Downtown property
  • 2 floors in hotel
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From$401
Average 3.0 /5 Recent Reviews Call BookMore Details
Embassy Suites Houston Downtown
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
1515 Dallas, Houston, TX 77010 +1-800-805-5223 ~3.43 miles north of 77221
  • Three Star Downtown hotel
  • Hotel has 5 meeting rooms
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From$135
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Sonder Midtown in Houston
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
306 Mcgowen St., Houston, TX 77006 +1-888-965-1860 ~3.44 miles northwest of 77221
  • Three Star Downtown property
  • 11 rooms in hotel
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From$75
Average 3.0 /5 Hotel Reviews Call BookMore Details
Holiday Inn Houston Downtown by IHG
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
1616 Main St., Houston, TX 77002 +1-888-788-5576 ~3.46 miles north of 77221
  • Three Star Downtown hotel
  • 213 sleeping rooms in hotel
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From$79
Poor 2.0 /5 Read Reviews Call BookMore Details
Marriott Marquis Houston in Houston
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
1777 Walker St., Houston, TX 77010 +1-888-897-9207 ~3.47 miles north of 77221
  • 4 star hotel
  • Check-in: 16:00
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From$375
Very Good 4.0 /5 Read Reviews Call BookMore Details
Courtyard by Marriott Houston Medical Center/NRG Park in Houston
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
Houston Medical Center 7702 Main St., Houston, TX 77030 +1-888-311-4278 ~3.48 miles west of 77221
  • Affordable Suburban hotel
  • Gym is available on property
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From$69
Very Good 4.0 /5 Read Reviews Call BookMore Details
Sonder Lofts at Ballpark : 610 St. Emanuel St. Houston Tx 77003
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
610 St. Emanuel St. Houston Tx 77003, Houston, TX 77003 +1-888-469-4795 ~3.48 miles north of 77221
  • Mid-scale Downtown hotel
  • Hotel has 22 suites
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From$100
Average 3.0 /5 Read Reviews Call BookMore Details
The Reside
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
7755 South Main St., Houston, TX 77054 +1-888-734-9421 ~3.51 miles west of 77221
  • Midscale Downtown hotel
  • 3 floors in hotel
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From$55
Very Good 4.0 /5 Review Score Call BookMore Details
Holiday Inn Houston S - Nrg Area - Medical Center by IHG
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
8111 Kirby Dr., Houston, TX 77054 +1-888-841-5292 ~3.51 miles west of 77221
  • 3 star Suburban property
  • 11 floors in property
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From$126
Average 3.5 /5 Latest Reviews Call BookMore Details
Four Seasons Hotel Houston
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
1300 Lamar St., Houston, TX 77010 +1-888-455-5160 ~3.51 miles north of 77221
  • Luxurious 5-star Downtown property
  • Check-in: 3:00 p.m.
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From$275
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Extended Stay America Suites Houston Med Ctr NRG Park Kirby in Houston
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
1303 La Concha Ln, Houston, TX 77054 +1-888-965-8297 ~3.52 miles west of 77221
  • Economical Convention Center property
  • 84 sleeping rooms in hotel
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From$41
Average 3.0 /5 Read Reviews Call BookMore Details
Courtyard Houston Medical Center / Nrg Park
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
7702 Main St., Houston, TX 77030 +1-888-906-6358 ~3.55 miles west of 77221
  • 3 star Downtown hotel
  • Check-in time: 03:00 PM
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From$80
Average 3.0 /5 Guest Reviews Call BookMore Details
Bayou City Event Center - Houston
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
9401 Knight Rd., Houston, TX 77045 +1-888-749-6785 ~3.56 miles southwest of 77221
  • Economical hotel
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From$60
Average 3.0 /5 Reviews Call BookMore Details
Residence Inn Houston Medical Center / Nrg Park : 7807 Kirby Dr.
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
7807 Kirby Dr., Houston, TX 77030 +1-888-878-9982 ~3.56 miles west of 77221
  • Three Star Downtown hotel
  • Free complimentary breakfast
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From$109
Very Good 4.0 /5 Review Score Call BookMore Details
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