Hotels in 77221 - Houston TX

Only hotels in 77221 zip code are listed below. Search for cheap and discount hotel rates in Houston, TX for your upcoming leisure or conference / group travel. We list the best 77221 hotels and motels so you can review the Houston hotel list below to find the perfect lodging. Hotels in Harris county and area code 713 are also listed.

77221 Hotels & Accommodations

Cliù Luxury Boutique Condo Hotel in Houston 3144 Southmore Blvd. Unit 10, Houston, TX 77004 Call ~1.13 miles northwest of 77221
  • High end Downtown hotel
  • 16 rooms in property
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From$100
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Extended Stay America Suites Houston Med Ctr Greenway Plaza : 2330 Southwest Frwy 2330 Southwest Frwy, Houston, TX 77098 Call ~1.16 miles west of 77221
  • 2 star Downtown hotel
  • Check-in: 3:00 PM
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From$61
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Summit Inn - Houston Medical Center 3138 Old Spanish Trail, Houston, TX 77054 Call ~1.37 miles west of 77221
  • Low priced hotel
  • Check in: 11:00
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From$60
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Mainstay Suites Texas Medical Center / Reliant Park : 3134 Old Spanish Trail 3134 Old Spanish Trail, Houston, TX 77054 Call ~1.41 miles west of 77221
  • Low-priced Convention Center hotel
  • Check in: 11:00
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From$60
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Hilton University of Houston : 4800 Calhoun Rd. 4800 Calhoun Rd., Houston, TX 77004 Call ~1.54 miles northeast of 77221
  • High-end Downtown hotel
  • Hotel has 86 rooms
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From$125
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Americas Best Value Inn Medical Center Downtown in Houston 2419 Riverside Dr., Houston, TX 77004 Call ~1.64 miles northwest of 77221
  • Low priced property
  • 40 rooms in hotel
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From$60
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Home2 Suites 6840 Almeda Rd., Houston, TX 77030 Call ~1.81 miles west of 77221
  • Midscale Suburban hotel
  • Hotel has an eco-friendly policy Read more
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From$99
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Hilton Garden Inn in Houston 6840b Almeda Rd., Houston, TX 77030 Call ~1.81 miles west of 77221
  • 3-star Suburban hotel
  • Gym / Fitness Center Available
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From$109
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Hilton Garden - Houston 6840 B Almeda Rd., Houston, TX 77030 Call ~1.82 miles west of 77221
  • Midscale hotel
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From$80
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Medical District 2700 Old Spanish Trail, Houston, TX 77021 Call ~1.92 miles west of 77221
  • Four-star property
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From$75
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Sonder The Hampstead in Houston 1508 Blodgett, Houston, TX 77004 Call ~2.32 miles northwest of 77221
  • 3-star Downtown hotel
  • 4 floors in property
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From$80
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Scott Inn Suites Downtown Houston - Houston 1933 Scott St., Houston, TX 77003 Call ~2.34 miles north of 77221
  • 3-star hotel
  • Hotel has 18 rooms
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From$90
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Best Way Inn Houston - Medical Center - Houston 3100 Holmes Rd., Houston, TX 77051 Call ~2.49 miles southwest of 77221
  • Low-priced hotel
  • Check in time: 13:00
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From$60
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Extended Stay America Suites Houston Med Ctr Braeswood Bl : 1301 Braeswood Blvd. 1301 Braeswood Blvd., Houston, TX 77030 Call ~2.52 miles west of 77221
  • 3 star Convention Center property
  • Check-in time: 3:00pm
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From$64
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Hotel Zaza Houston Museum District 5701 Main St., Houston, TX 77005 Call ~2.57 miles northwest of 77221
  • Four-star Downtown property
  • Check in time: 4:00 PM
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From$159
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Blossom Houston Medical Center 7114 Bertner Ave., Houston, TX 77030 Call ~2.68 miles west of 77221
  • Three Star property
  • 230 sleeping rooms in hotel
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From$90
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Blossom Hotel Houston - Houston 7118 Bertner Ave., Houston, TX 77030 Call ~2.68 miles west of 77221
  • High-end Convention Center property
  • 267 rooms in property
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From$169
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Days Inn & Suites by Wyndham Downtown / University of Houston : 6190 Gulf Freeway 6190 Gulf Freeway, Houston, TX 77023 Call ~2.72 miles east of 77221
  • Midscale Downtown hotel
  • Check-in time: 2:00pm
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From$55
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Lexington Hotel Houston Medical Center in Houston 1025 Swanson St., Houston, TX 77030 Call ~2.78 miles west of 77221
  • 2-star Downtown hotel
  • Check-in: 3:00 PM
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From$60
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Hyatt Place : 7329a Fannin St. 7329a Fannin St., Houston, TX 77030 Call ~2.78 miles west of 77221
  • Affordable hotel
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From$80
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Hyatt Place Hyatt House Houston Medical Center 7329 Fannin St., Houston, TX 77030 Call ~2.78 miles west of 77221
  • Mid-scale Suburban hotel
  • Check in time: 3PM
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From$99
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Houston Marriott Medical Center/Museum District in Houston 6580 Fannin St., Houston, TX 77030 Call ~2.80 miles west of 77221
  • 4-star Downtown hotel
  • 22 suites in property
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The Westin Hou Medical Center 1709 Dryden Rd., Houston, TX 77030 Call ~2.81 miles west of 77221
  • Midscale hotel
  • 273 sleeping rooms in hotel
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From$90
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Sonder at Mid Main - Houston 3550 Main St., Houston, TX 77002 Call ~2.86 miles northwest of 77221
  • Affordable Downtown property
  • 26 sleeping rooms in hotel
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From$75
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Hampton Inn & Suites Houston Medical Center Nrg Park in Houston 1715 Old Spanish Trail, Houston, TX 77054 Call ~2.91 miles west of 77221
  • Mid-scale Convention Center hotel
  • Hotel has 5 floors
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From$69
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Houston Medical Center Hotel : 6700 Main St. 6700 Main St., Houston, TX 77030 Call ~2.94 miles west of 77221
  • Midscale Downtown hotel
  • 125 rooms in hotel
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From$115
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InterContinental Houston by IHG 6750 Main St., Houston, TX 77030 Call ~2.98 miles west of 77221
  • High-end Downtown property
  • 37 suites in hotel
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From$75
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Doubletree by Hilton Houston Medical Center Hotel & Suites in Houston 6800 Main St., Houston, TX 77030 Call ~3.01 miles west of 77221
  • Four-star Downtown hotel
  • Airport shuttle provided
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From$125
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Extended Stay America - Houston - Med Ctr-NRG Park-Fannin 7979 Fannin, Houston, TX 77054 Call ~3.01 miles west of 77221
  • Two-star Convention Center hotel
  • Check-in time: 3pm
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From$49
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Best Western Premier Houston Downtown/Convention Center Hotel 1810 Bell St., Houston, TX 77003 Call ~3.12 miles north of 77221
  • Affordable Downtown hotel
  • 112 rooms in property
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Wanderstay Boutique Hotel in Houston 520 Sampson St., Houston, TX 77003 Call ~3.15 miles north of 77221
  • High end hotel
  • 2 suites in hotel
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From$125
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SpringHill Suites Houston Medical Center/NRG Park - Houston 1400 Old Spanish Trl, Houston, TX 77054 Call ~3.32 miles west of 77221
  • Midscale Downtown property
  • 7 floors in hotel
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From$80
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Whyhotel Houston Downtown : 1515 Austin St. 1515 Austin St., Houston, TX 77002 Call ~3.33 miles north of 77221
  • Affordable property
  • 103 rooms in property
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From$90
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Athens Hotel Suites in Houston 1308 Clay St., Houston, TX 77002 Call ~3.39 miles north of 77221
  • Mid-scale Downtown property
  • Check in: 3PM
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From$89
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La Colombe D Or Hotel : 3410 Montrose Blvd. 3410 Montrose Blvd., Houston, TX 77006 Call ~3.40 miles northwest of 77221
  • Affordable hotel
  • 15 rooms in property
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From$90
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Hilton Americas Houston in Houston 1600 Lamar St., Houston, TX 77010 Call ~3.40 miles north of 77221
  • Expensive Downtown property
  • Has environment-friendly policy Learn more
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From$101
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Hotel Saint Augustine 4110 Loretto Dr., Houston, TX 77006 Call ~3.41 miles northwest of 77221
  • High end Downtown hotel
  • 71 rooms in hotel
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From$401
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Embassy Suites Houston Downtown - Houston 1515 Dallas, Houston, TX 77010 Call ~3.42 miles north of 77221
  • Three Star Downtown property
  • 5 conference rooms in property
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From$135
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Sonder Midtown - Houston 306 Mcgowen St., Houston, TX 77006 Call ~3.44 miles northwest of 77221
  • 3 star Downtown hotel
  • Check-in time: 4:00 PM
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From$75
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Holiday Inn Houston Downtown by IHG 1616 Main St., Houston, TX 77002 Call ~3.46 miles north of 77221
  • Three Star Downtown property
  • 213 sleeping rooms in hotel
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From$79
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Marriott Marquis Houston 1777 Walker St., Houston, TX 77010 Call ~3.46 miles north of 77221
  • Four star property
  • Fitness / Gym is on-site
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From$375
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Courtyard by Marriott Houston Medical Center/NRG Park : Houston Medical Center 7702 Main St. Houston Medical Center 7702 Main St., Houston, TX 77030 Call ~3.47 miles west of 77221
  • 3-star Suburban hotel
  • Hotel has an eco-friendly policy See more
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From$69
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Sonder Lofts at Ballpark in Houston 610 St. Emanuel St. Houston Tx 77003, Houston, TX 77003 Call ~3.47 miles north of 77221
  • Mid-scale Downtown property
  • Check-in: 4:00 PM
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From$100
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The Reside 7755 South Main St., Houston, TX 77054 Call ~3.50 miles west of 77221
  • Mid-scale Downtown property
  • Check in: 2:00PM
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From$55
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Holiday Inn Houston S Nrg Area Medical Center by IHG - Houston 8111 Kirby Dr., Houston, TX 77054 Call ~3.50 miles west of 77221
  • 3 star Suburban hotel
  • Gym / Fitness Center Available
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From$126
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Four Seasons Hotel Houston - Houston 1300 Lamar St., Houston, TX 77010 Call ~3.51 miles north of 77221
  • Luxury 5 star Downtown hotel
  • Check-in: 3:00 p.m.
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From$275
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Extended Stay America Suites Houston Med Ctr NRG Park Kirby in Houston 1303 La Concha Ln, Houston, TX 77054 Call ~3.52 miles west of 77221
  • Low Cost Convention Center property
  • 84 sleeping rooms in hotel
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From$41
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Courtyard Houston Medical Center / Nrg Park - Houston 7702 Main St., Houston, TX 77030 Call ~3.55 miles west of 77221
  • Mid-scale Downtown property
  • Gym is available on property
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From$80
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Bayou City Event Center : 9401 Knight Rd. 9401 Knight Rd., Houston, TX 77045 Call ~3.55 miles southwest of 77221
  • 2 star property
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From$60
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Residence Inn Houston Medical Center / Nrg Park in Houston 7807 Kirby Dr., Houston, TX 77030 Call ~3.56 miles west of 77221
  • Midscale Downtown hotel
  • 182 suites in hotel
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From$109
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