Hotels in 77221 - Houston TX

Only hotels in 77221 zip code are listed below. Search for cheap and discount hotel rates in Houston, TX for your upcoming leisure or conference / group travel. We list the best 77221 hotels and motels so you can review the Houston hotel list below to find the perfect lodging. Hotels in Harris county and area code 713 are also listed.

77221 Hotels, Motels & Accommodations

Cliù Luxury Boutique Condo Hotel
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
3144 Southmore Blvd. Unit 10, Houston, TX 77004 +1-888-389-4121 ~1.13 miles northwest of 77221
  • High end Downtown property
  • Hotel has 8 suites
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From$100
Average 3.0 /5 Recent Reviews Call BookMore Details
Extended Stay America Suites Houston Med Ctr Greenway Plaza
+1-888-675-2083

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New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
2330 Southwest Frwy, Houston, TX 77098 +1-888-675-2083 ~1.16 miles west of 77221
  • Inexpensive Downtown property
  • 3 floors in hotel
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From$61
Average 3.0 /5 Reviews Call BookMore Details
Summit Inn - Houston Medical Center : 3138 Old Spanish Trail
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
3138 Old Spanish Trail, Houston, TX 77054 +1-800-716-8490 ~1.37 miles west of 77221
  • Low Cost hotel
  • Hotel has 33 rooms
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From$60
Average 3.0 /5 Hotel Reviews Call BookMore Details
Mainstay Suites Texas Medical Center / Reliant Park
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
3134 Old Spanish Trail, Houston, TX 77054 +1-800-805-5223 ~1.41 miles west of 77221
  • Low priced Convention Center property
  • Access to gym on-site
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From$60
Very Good 4.0 /5 Review Score Call BookMore Details
Hilton University of Houston
+1-888-965-1860

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New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
4800 Calhoun Rd., Houston, TX 77004 +1-888-965-1860 ~1.54 miles northeast of 77221
  • Four-star Downtown hotel
  • Check in: 3:00PM
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From$125
Average 3.0 /5 Read Reviews Call BookMore Details
Americas Best Value Inn Medical Center Downtown in Houston
+1-888-788-5576

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New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
2419 Riverside Dr., Houston, TX 77004 +1-888-788-5576 ~1.64 miles northwest of 77221
  • Low priced hotel
  • Hotel has 2 floors
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From$60
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Home2 Suites
+1-888-897-9207

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New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
6840 Almeda Rd., Houston, TX 77030 +1-888-897-9207 ~1.81 miles west of 77221
  • Midscale Suburban hotel
  • Check in: 4:00 PM
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From$99
Excellent 5.0 /5 Review Score Call BookMore Details
Hilton Garden Inn
+1-888-311-4278

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New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
6840b Almeda Rd., Houston, TX 77030 +1-888-311-4278 ~1.81 miles west of 77221
  • 3 star Suburban hotel
  • 10 floors in hotel
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From$109
Average 3.0 /5 Reviews Call BookMore Details
Hilton Garden : 6840 B Almeda Rd.
+1-888-469-4795

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New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
6840 B Almeda Rd., Houston, TX 77030 +1-888-469-4795 ~1.82 miles west of 77221
  • 3-star property
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From$80
Average 3.0 /5 Review Score Call BookMore Details
Medical District
+1-888-734-9421

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New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
2700 Old Spanish Trail, Houston, TX 77021 +1-888-734-9421 ~1.92 miles west of 77221
  • 4 star property
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From$75
Average 3.0 /5 Reviews Call BookMore Details
Sonder The Hampstead
+1-888-841-5292

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New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
1508 Blodgett, Houston, TX 77004 +1-888-841-5292 ~2.32 miles northwest of 77221
  • 3 star Downtown hotel
  • 36 rooms in property
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From$80
Average 3.0 /5 Read Reviews Call BookMore Details
Scott Inn Suites Downtown Houston in Houston
+1-888-455-5160

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New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
1933 Scott St., Houston, TX 77003 +1-888-455-5160 ~2.34 miles north of 77221
  • 3-star property
  • Hotel has 18 rooms
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From$90
Very Good 4.0 /5 Reviews Call BookMore Details
Best Way Inn Houston - Medical Center : 3100 Holmes Rd.
+1-888-965-8297

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New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
3100 Holmes Rd., Houston, TX 77051 +1-888-965-8297 ~2.49 miles southwest of 77221
  • Cheap property
  • Hotel has 42 rooms
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From$60
Average 3.0 /5 Hotel Reviews Call BookMore Details
Extended Stay America Suites Houston Med Ctr Braeswood Bl : 1301 Braeswood Blvd.
+1-888-906-6358

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New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
1301 Braeswood Blvd., Houston, TX 77030 +1-888-906-6358 ~2.52 miles west of 77221
  • 3 star Convention Center hotel
  • 130 rooms in property
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From$64
Average 3.0 /5 Guest Reviews Call BookMore Details
Hotel Zaza Houston Museum District
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
5701 Main St., Houston, TX 77005 +1-888-749-6785 ~2.57 miles northwest of 77221
  • Four-star Downtown hotel
  • Fitness center on property
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From$159
Very Good 4.5 /5 Read Reviews Call BookMore Details
Blossom Houston Medical Center
+1-888-878-9982

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New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
7114 Bertner Ave., Houston, TX 77030 +1-888-878-9982 ~2.68 miles west of 77221
  • Three Star property
  • Check-in: 16:00
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From$90
Very Good 4.0 /5 Reviews Call BookMore Details
Blossom Hotel Houston - Houston
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
7118 Bertner Ave., Houston, TX 77030 +1-888-389-4485 ~2.68 miles west of 77221
  • High end Convention Center hotel
  • 16 floors in hotel
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From$169
Average 3.0 /5 Reviews Call BookMore Details
Days Inn & Suites by Wyndham Downtown / University of Houston
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
6190 Gulf Freeway, Houston, TX 77023 +1-888-389-4121 ~2.72 miles east of 77221
  • 3-star Downtown property
  • Fitness + Health Center
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From$55
Average 3.0 /5 Reviews Call BookMore Details
Lexington Hotel Houston Medical Center
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
1025 Swanson St., Houston, TX 77030 +1-888-675-2083 ~2.78 miles west of 77221
  • Economical Downtown property
  • Fitness / Gym is on-site
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From$60
Average 3.5 /5 Hotel Reviews Call BookMore Details
Hyatt Place
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
7329a Fannin St., Houston, TX 77030 +1-800-716-8490 ~2.78 miles west of 77221
  • 3-star hotel
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From$80
Average 3.0 /5 Latest Reviews Call BookMore Details
Hyatt Place Hyatt House Houston Medical Center - Houston
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
7329 Fannin St., Houston, TX 77030 +1-800-805-5223 ~2.78 miles west of 77221
  • Mid-scale Suburban hotel
  • 298 sleeping rooms in hotel
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From$99
Average 3.0 /5 Review Score Call BookMore Details
Houston Marriott Medical Center/Museum District in Houston
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
6580 Fannin St., Houston, TX 77030 +1-888-965-1860 ~2.80 miles west of 77221
  • High end Downtown hotel
  • Hotel has 22 suites
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From$75
Very Good 4.5 /5 Recent Reviews Call BookMore Details
The Westin Hou Medical Center
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
1709 Dryden Rd., Houston, TX 77030 +1-888-788-5576 ~2.81 miles west of 77221
  • 3-star hotel
  • Gym is available on property
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From$90
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Sonder at Mid Main
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
3550 Main St., Houston, TX 77002 +1-888-897-9207 ~2.86 miles northwest of 77221
  • Midscale Downtown property
  • Access to gym on-site
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From$75
Average 3.0 /5 Recent Reviews Call BookMore Details
Hampton Inn & Suites Houston Medical Center Nrg Park in Houston
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
1715 Old Spanish Trail, Houston, TX 77054 +1-888-311-4278 ~2.91 miles west of 77221
  • Midscale Convention Center hotel
  • 3 meeting rooms in property
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From$69
Very Good 4.0 /5 Read Reviews Call BookMore Details
Houston Medical Center Hotel in Houston
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
6700 Main St., Houston, TX 77030 +1-888-469-4795 ~2.94 miles west of 77221
  • Affordable Downtown property
  • 25 suites in property
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From$115
Average 3.5 /5 Hotel Reviews Call BookMore Details
InterContinental Houston by IHG
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
6750 Main St., Houston, TX 77030 +1-888-734-9421 ~2.98 miles west of 77221
  • High-end Downtown hotel
  • Fitness + Health Center
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From$75
Average 3.0 /5 Review Score Call BookMore Details
Doubletree by Hilton Houston Medical Center Hotel & Suites
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
6800 Main St., Houston, TX 77030 +1-888-841-5292 ~3.01 miles west of 77221
  • High end Downtown hotel
  • Check-in time: 3:00PM
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From$125
Average 3.0 /5 Read Reviews Call BookMore Details
Extended Stay America - Houston - Med Ctr-NRG Park-Fannin - Houston
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
7979 Fannin, Houston, TX 77054 +1-888-455-5160 ~3.01 miles west of 77221
  • Low Cost Convention Center property
  • Check-in: 3pm
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From$49
Poor 2.5 /5 Latest Reviews Call BookMore Details
BW Premier Houston Downtown / Convention Center Hotel
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
1810 Bell St., Houston, TX 77003 +1-888-965-8297 ~3.12 miles north of 77221
  • Mid-scale Downtown hotel
  • 22 suites in hotel
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From$80
Average 3.0 /5 Read Reviews Call BookMore Details
Wanderstay Boutique Hotel
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
520 Sampson St., Houston, TX 77003 +1-888-906-6358 ~3.15 miles north of 77221
  • 4 star property
  • 10 sleeping rooms in hotel
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From$125
Average 3.0 /5 Review Score Call BookMore Details
SpringHill Suites Houston Medical Center/NRG Park : 1400 Old Spanish Trl
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
1400 Old Spanish Trl, Houston, TX 77054 +1-888-749-6785 ~3.32 miles west of 77221
  • 3 star Downtown property
  • Check-in time: 3.00 pm
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From$80
Average 3.0 /5 Review Score Call BookMore Details
Whyhotel Houston Downtown in Houston
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
1515 Austin St., Houston, TX 77002 +1-888-878-9982 ~3.33 miles north of 77221
  • 3-star hotel
  • Check in: 15:00
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From$90
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Athens Hotel Suites
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
1308 Clay St., Houston, TX 77002 +1-888-389-4485 ~3.39 miles north of 77221
  • 3 star Downtown property
  • Free breakfast available
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From$89
Average 3.0 /5 Read Reviews Call BookMore Details
Hilton Americas Houston
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
1600 Lamar St., Houston, TX 77010 +1-888-389-4121 ~3.40 miles north of 77221
  • Four star Downtown property
  • Has environment-friendly policy Learn more
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From$101
Very Good 4.5 /5 Latest Reviews Call BookMore Details
La Colombe D Or Hotel in Houston
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
3410 Montrose Blvd., Houston, TX 77006 +1-888-675-2083 ~3.40 miles northwest of 77221
  • 3-star hotel
  • 15 sleeping rooms in hotel
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From$90
Average 3.0 /5 Latest Reviews Call BookMore Details
Hotel Saint Augustine in Houston
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
4110 Loretto Dr., Houston, TX 77006 +1-800-716-8490 ~3.41 miles northwest of 77221
  • Four-star Downtown hotel
  • Check-in: 3:00 PM
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From$401
Average 3.0 /5 Recent Reviews Call BookMore Details
Embassy Suites by Hilton Houston Downtown Convention Center in Houston
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
1515 Dallas, Houston, TX 77010 +1-800-805-5223 ~3.42 miles north of 77221
  • Affordable Downtown property
  • 5 conference rooms in property
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From$135
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Embassy Suites Houston Downtown in Houston
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
1515 Dallas St., Houston, TX 77002 +1-888-965-1860 ~3.42 miles north of 77221
  • 3-star Downtown property
  • Fitness / Gym is on-site
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From$199
Average 3.0 /5 Read Reviews Call BookMore Details
Sonder Midtown
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
306 Mcgowen St., Houston, TX 77006 +1-888-788-5576 ~3.44 miles northwest of 77221
  • Mid-scale Downtown property
  • Gym / Fitness Center Available
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From$75
Average 3.0 /5 Recent Reviews Call BookMore Details
Holiday Inn Houston Downtown by IHG
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
1616 Main St., Houston, TX 77002 +1-888-897-9207 ~3.46 miles north of 77221
  • 3-star Downtown hotel
  • Check-in time: 3:00 PM
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From$79
Poor 2.0 /5 Review Score Call BookMore Details
Marriott Marquis Houston - Houston
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
1777 Walker St., Houston, TX 77010 +1-888-311-4278 ~3.46 miles north of 77221
  • Four-star property
  • Check-in: 16:00
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From$375
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Courtyard By Marriott Houston Medical Center Reliant Park
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
Houston Medical Center 7702 Main St., Houston, TX 77030 +1-888-469-4795 ~3.47 miles west of 77221
  • Affordable Suburban hotel
  • Fitness center on property
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From$69
Very Good 4.0 /5 Read Reviews Call BookMore Details
Sonder Lofts at Ballpark - Houston
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
610 St. Emanuel St. Houston Tx 77003, Houston, TX 77003 +1-888-734-9421 ~3.47 miles north of 77221
  • Mid-scale Downtown hotel
  • 22 rooms in property
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From$100
Average 3.0 /5 Hotel Reviews Call BookMore Details
The Reside
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
7755 South Main St., Houston, TX 77054 +1-888-841-5292 ~3.50 miles west of 77221
  • 3-star Downtown hotel
  • Check-in: 2:00PM
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From$55
Very Good 4.0 /5 Read Reviews Call BookMore Details
Holiday Inn Houston S - Nrg Area - Medical Center by IHG in Houston
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
8111 Kirby Dr., Houston, TX 77054 +1-888-455-5160 ~3.50 miles west of 77221
  • Midscale Suburban property
  • Fitness + Health Center
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From$126
Average 3.5 /5 Reviews Call BookMore Details
Four Seasons Hotel Houston
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
1300 Lamar St., Houston, TX 77010 +1-888-965-8297 ~3.51 miles north of 77221
  • Luxurious 5 Star Downtown hotel
  • 12 meeting rooms in property
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From$275
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Extended Stay America Suites Houston Med Ctr NRG Park Kirby - Houston
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
1303 La Concha Ln, Houston, TX 77054 +1-888-906-6358 ~3.52 miles west of 77221
  • Low-priced Convention Center hotel
  • Hotel has 45 suites
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From$41
Average 3.0 /5 Reviews Call BookMore Details
Courtyard Houston Medical Center / Nrg Park in Houston
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
7702 Main St., Houston, TX 77030 +1-888-749-6785 ~3.55 miles west of 77221
  • 3 star Downtown property
  • Hotel has an eco-friendly policy Learn more
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From$80
Average 3.0 /5 Latest Reviews Call BookMore Details
Bayou City Event Center in Houston
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
9401 Knight Rd., Houston, TX 77045 +1-888-878-9982 ~3.55 miles southwest of 77221
  • 2-star property
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From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
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