Hotels in 77221 - Houston TX

Only hotels in 77221 zip code are listed below. Search for cheap and discount hotel rates in Houston, TX for your upcoming leisure or conference / group travel. We list the best 77221 hotels and motels so you can review the Houston hotel list below to find the perfect lodging. Hotels in Harris county and area code 713 are also listed.

77221 Hotels & Accommodations

Cliù Luxury Boutique Condo Hotel
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
3144 Southmore Blvd. Unit 10, Houston, TX 77004 +1-888-389-4121 ~1.13 miles northwest of 77221
  • Four-star Downtown property
  • Hotel has 8 suites
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From$100
Average 3.0 /5 Guest Reviews Call BookMore Details
Extended Stay America Suites Houston Med Ctr Greenway Plaza : 2330 Southwest Frwy
+1-888-675-2083

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New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
2330 Southwest Frwy, Houston, TX 77098 +1-888-675-2083 ~1.17 miles west of 77221
  • 2 star Downtown hotel
  • Check in time: 3:00 PM
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From$61
Average 3.0 /5 Review Score Call BookMore Details
Summit Inn - Houston Medical Center
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
3138 Old Spanish Trail, Houston, TX 77054 +1-800-716-8490 ~1.37 miles west of 77221
  • Economy property
  • 33 rooms in property
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From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
Mainstay Suites Medical Center / Reliant Park
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
3134 Old Spanish Trail, Houston, TX 77054 +1-800-805-5223 ~1.41 miles west of 77221
  • Low priced Convention Center property
  • Fitness + Health Center
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From$60
Very Good 4.0 /5 Review Score Call BookMore Details
Hiton University of Houston
+1-888-965-1860

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New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
4800 Calhoun Rd., Houston, TX 77004 +1-888-965-1860 ~1.54 miles northeast of 77221
  • Expensive Downtown property
  • 12 suites in hotel
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From$125
Average 3.0 /5 Hotel Reviews Call BookMore Details
Americas Best Value Inn Medical Center Downtown in Houston
+1-888-788-5576

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New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
2419 Riverside Dr., Houston, TX 77004 +1-888-788-5576 ~1.65 miles northwest of 77221
  • Low Cost property
  • Free comp. breakfast
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From$60
Very Good 4.0 /5 Review Score Call BookMore Details
Home2 Suites : 6840 Almeda Rd.
+1-888-897-9207

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New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
6840 Almeda Rd., Houston, TX 77030 +1-888-897-9207 ~1.82 miles west of 77221
  • Affordable Suburban hotel
  • 143 sleeping rooms in hotel
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From$99
Excellent 5.0 /5 Guest Reviews Call BookMore Details
Hilton Garden Inn
+1-888-311-4278

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New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
6840b Almeda Rd., Houston, TX 77030 +1-888-311-4278 ~1.82 miles west of 77221
  • 3-star Suburban hotel
  • Hotel has an eco-friendly policy Read more
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From$109
Average 3.0 /5 Read Reviews Call BookMore Details
Hilton Garden - Houston
+1-888-469-4795

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New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
6840 B Almeda Rd., Houston, TX 77030 +1-888-469-4795 ~1.82 miles west of 77221
  • Mid-scale property
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From$80
Average 3.0 /5 Reviews Call BookMore Details
Medical District - Houston
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
2700 Old Spanish Trail, Houston, TX 77021 +1-888-734-9421 ~1.92 miles west of 77221
  • 4 star hotel
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From$75
Average 3.0 /5 Hotel Reviews Call BookMore Details
Sonder The Hampstead - Houston
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
1508 Blodgett, Houston, TX 77004 +1-888-841-5292 ~2.33 miles northwest of 77221
  • Midscale Downtown hotel
  • 36 rooms in property
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From$80
Average 3.0 /5 Read Reviews Call BookMore Details
Scott Inn Suites Downtown Houston in Houston
+1-888-455-5160

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New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
1933 Scott St., Houston, TX 77003 +1-888-455-5160 ~2.34 miles north of 77221
  • Affordable hotel
  • 18 rooms in hotel
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From$90
Very Good 4.0 /5 Review Score Call BookMore Details
Best Way Inn Houston - Medical Center
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
3100 Holmes Rd., Houston, TX 77051 +1-888-965-8297 ~2.49 miles southwest of 77221
  • Two-star property
  • Check in time: 13:00
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From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
Extended Stay America Suites Houston Med Ctr Braeswood Bl : 1301 Braeswood Blvd.
+1-888-906-6358

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New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
1301 Braeswood Blvd., Houston, TX 77030 +1-888-906-6358 ~2.52 miles west of 77221
  • Midscale Convention Center property
  • Check in time: 3:00pm
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From$64
Average 3.0 /5 Recent Reviews Call BookMore Details
Hotel Zaza Houston Museum District - Houston
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
5701 Main St., Houston, TX 77005 +1-888-749-6785 ~2.57 miles northwest of 77221
  • Expensive Downtown hotel
  • Hotel has 15 meeting rooms
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From$159
Very Good 4.5 /5 Recent Reviews Call BookMore Details
Blossom Houston Medical Center : 7114 Bertner Ave.
+1-888-878-9982

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New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
7114 Bertner Ave., Houston, TX 77030 +1-888-878-9982 ~2.68 miles west of 77221
  • Midscale hotel
  • Check in time: 16:00
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From$90
Very Good 4.0 /5 Review Score Call BookMore Details
Blossom Hotel Houston
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
7118 Bertner Ave., Houston, TX 77030 +1-888-389-4485 ~2.69 miles west of 77221
  • Expensive Convention Center hotel
  • 37 suites in hotel
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From$125
Average 3.0 /5 Latest Reviews Call BookMore Details
Days Inn & Suites by Wyndham Downtown / University of Houston : 6190 Gulf Freeway
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
6190 Gulf Freeway, Houston, TX 77023 +1-888-389-4121 ~2.73 miles east of 77221
  • Midscale Downtown hotel
  • Comp. Breakfast
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From$55
Average 3.0 /5 Reviews Call BookMore Details
Lexington Hotel Houston Medical Center : 1025 Swanson St.
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
1025 Swanson St., Houston, TX 77030 +1-888-675-2083 ~2.78 miles west of 77221
  • Two-star Downtown hotel
  • Fitness + Health Center
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From$60
Average 3.5 /5 Review Score Call BookMore Details
Hyatt Place in Houston
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
7329a Fannin St., Houston, TX 77030 +1-800-716-8490 ~2.79 miles west of 77221
  • 3 star hotel
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From$80
Average 3.0 /5 Latest Reviews Call BookMore Details
Hyatt Place Hyatt House Houston Medical Center - Houston
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
7329 Fannin St., Houston, TX 77030 +1-800-805-5223 ~2.79 miles west of 77221
  • Midscale Suburban property
  • Hotel has 3 meeting rooms
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From$99
Average 3.0 /5 Hotel Reviews Call BookMore Details
Houston Marriott Medical Center/Museum District
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
6580 Fannin St., Houston, TX 77030 +1-888-965-1860 ~2.80 miles west of 77221
  • High-end Downtown property
  • Hotel has 386 rooms
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From$75
Very Good 4.5 /5 Read Reviews Call BookMore Details
The Westin Hou Medical Center : 1709 Dryden Rd.
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
1709 Dryden Rd., Houston, TX 77030 +1-888-788-5576 ~2.81 miles west of 77221
  • Mid-scale hotel
  • Fitness / Gym is on-site
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From$90
Very Good 4.0 /5 Read Reviews Call BookMore Details
Sonder at Mid Main in Houston
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
3550 Main St., Houston, TX 77002 +1-888-897-9207 ~2.87 miles northwest of 77221
  • Midscale Downtown property
  • 12 suites in property
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From$75
Average 3.0 /5 Latest Reviews Call BookMore Details
Hampton Inn & Suites Houston Medical Center Nrg Park
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
1715 Old Spanish Trail, Houston, TX 77054 +1-888-311-4278 ~2.92 miles west of 77221
  • 3-star Convention Center hotel
  • Free comp. breakfast
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From$69
Very Good 4.0 /5 Latest Reviews Call BookMore Details
SureStay Plus by Best Western Houston Medical Center - Houston
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
6700 Main St., Houston, TX 77030 +1-888-469-4795 ~2.94 miles west of 77221
  • Affordable Downtown hotel
  • 25 suites in hotel
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From$56
Average 3.5 /5 Reviews Call BookMore Details
InterContinental Houston, an IHG Hotel in Houston
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
6750 Main St., Houston, TX 77030 +1-888-734-9421 ~2.98 miles west of 77221
  • High-end Downtown hotel
  • Check-in time: 15:00
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From$75
Average 3.0 /5 Latest Reviews Call BookMore Details
Doubletree by Hilton Houston Medical Center Hotel & Suites
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
6800 Main St., Houston, TX 77030 +1-888-841-5292 ~3.01 miles west of 77221
  • 3 star Downtown property
  • Airport shuttle provided
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From$80
Average 3.0 /5 Guest Reviews Call BookMore Details
Extended Stay America - Houston - Med Ctr-NRG Park-Fannin - Houston
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
7979 Fannin, Houston, TX 77054 +1-888-455-5160 ~3.02 miles west of 77221
  • Economical Convention Center property
  • Check-in: 3pm
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From$49
Poor 2.5 /5 Review Score Call BookMore Details
Holiday Inn Express Hotel & Suites Houston-Downtown Conv Ctr, an - Houston
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
1810 Bell St., Houston, TX 77003 +1-888-965-8297 ~3.11 miles north of 77221
  • Mid-scale Downtown property
  • Free comp. breakfast
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From$108
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Springhill Suites Marriott Medical Center Nrg Park - Houston
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
1400 Old Spanish Trail, Houston, TX 77054 +1-888-906-6358 ~3.33 miles west of 77221
  • Mid-scale Downtown hotel
  • Comp. Breakfast
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From$80
Average 3.0 /5 Hotel Reviews Call BookMore Details
Whyhotel Houston Downtown - Houston
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
1515 Austin St., Houston, TX 77002 +1-888-749-6785 ~3.33 miles north of 77221
  • Mid-scale hotel
  • 103 rooms in hotel
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From$90
Very Good 4.0 /5 Review Score Call BookMore Details
Athens Hotel Suites
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
1308 Clay St., Houston, TX 77002 +1-888-878-9982 ~3.39 miles north of 77221
  • 3-star Downtown property
  • 21 sleeping rooms in hotel
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From$89
Average 3.0 /5 Guest Reviews Call BookMore Details
Hilton Americas Houston - Houston
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
1600 Lamar St., Houston, TX 77010 +1-888-389-4485 ~3.41 miles north of 77221
  • Four star Downtown hotel
  • Hotel has 66 suites
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From$101
Very Good 4.5 /5 Hotel Reviews Call BookMore Details
La Colombe D Or Hotel in Houston
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
3410 Montrose Blvd., Houston, TX 77006 +1-888-389-4121 ~3.41 miles northwest of 77221
  • Three Star property
  • Check-in: 16:00
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From$90
Average 3.0 /5 Reviews Call BookMore Details
Hotel Saint Augustine
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
4110 Loretto Dr., Houston, TX 77006 +1-888-675-2083 ~3.41 miles northwest of 77221
  • High-end Downtown property
  • 71 rooms in hotel
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From$250
Average 3.0 /5 Guest Reviews Call BookMore Details
Embassy Suites Houston Downtown - Houston
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
1515 Dallas, Houston, TX 77010 +1-800-716-8490 ~3.43 miles north of 77221
  • Three Star Downtown property
  • 5 conference rooms in property
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From$135
Very Good 4.0 /5 Review Score Call BookMore Details
Sonder Midtown
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
306 Mcgowen St., Houston, TX 77006 +1-800-805-5223 ~3.44 miles northwest of 77221
  • Affordable Downtown hotel
  • Hotel has 6 floors
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From$75
Average 3.0 /5 Read Reviews Call BookMore Details
Holiday Inn Houston Downtown, an IHG Hotel
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
1616 Main St., Houston, TX 77002 +1-888-965-1860 ~3.46 miles north of 77221
  • Mid-scale Downtown hotel
  • 213 rooms in property
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From$79
Poor 2.0 /5 Latest Reviews Call BookMore Details
Marriott Marquis Houston in Houston
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
1777 Walker St., Houston, TX 77010 +1-888-788-5576 ~3.47 miles north of 77221
  • 4 star hotel
  • 1000 rooms in property
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From$375
Very Good 4.0 /5 Read Reviews Call BookMore Details
Courtyard by Marriott Houston Medical Center/NRG Park in Houston
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
Houston Medical Center 7702 Main St., Houston, TX 77030 +1-888-897-9207 ~3.48 miles west of 77221
  • Affordable Suburban hotel
  • Hotel has a green policy See more
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From$69
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Sonder Lofts at Ballpark - Houston
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
610 St. Emanuel St. Houston Tx 77003, Houston, TX 77003 +1-888-311-4278 ~3.48 miles north of 77221
  • Midscale Downtown hotel
  • Fitness + Health Center
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From$100
Average 3.0 /5 Recent Reviews Call BookMore Details
The Reside in Houston
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
7755 South Main St., Houston, TX 77054 +1-888-469-4795 ~3.51 miles west of 77221
  • 3-star Downtown property
  • Fitness / Gym is on-site
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From$55
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Holiday Inn Houston S - Nrg Area - Medical Center, an IHG Hotel in Houston
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
8111 Kirby Dr., Houston, TX 77054 +1-888-734-9421 ~3.51 miles west of 77221
  • Affordable Suburban hotel
  • Fitness + Health Center
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From$126
Average 3.5 /5 Hotel Reviews Call BookMore Details
Four Seasons Hotel Houston - Houston
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
1300 Lamar St., Houston, TX 77010 +1-888-841-5292 ~3.51 miles north of 77221
  • Luxury 5-star Downtown property
  • Check-in: 3:00 p.m.
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From$275
Very Good 4.0 /5 Review Score Call BookMore Details
Extended Stay America Suites Houston Med Ctr NRG Park Kirby in Houston
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
1303 La Concha Ln, Houston, TX 77054 +1-888-455-5160 ~3.52 miles west of 77221
  • Cheap Convention Center hotel
  • Fitness / Gym is on-site
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From$41
Average 3.0 /5 Read Reviews Call BookMore Details
Courtyard Houston Medical Center / Nrg Park
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
7702 Main St., Houston, TX 77030 +1-888-965-8297 ~3.55 miles west of 77221
  • Midscale Downtown hotel
  • 197 sleeping rooms in hotel
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From$80
Average 3.0 /5 Recent Reviews Call BookMore Details
Bayou City Event Center - Houston
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
9401 Knight Rd., Houston, TX 77045 +1-888-906-6358 ~3.56 miles southwest of 77221
  • Two star property
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From$60
Average 3.0 /5 Review Score Call BookMore Details
Residence Inn Houston Medical Center / Nrg Park in Houston
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
7807 Kirby Dr., Houston, TX 77030 +1-888-749-6785 ~3.56 miles west of 77221
  • 3 star Downtown hotel
  • Check in time: 4:00 PM
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From$109
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Moody Manor - Houston
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
7706 Main St., Houston, TX 77030 +1-888-878-9982 ~3.58 miles west of 77221
  • Affordable Downtown hotel
  • Check-in time: 3:00pm
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From$69
Average 3.5 /5 Guest Reviews Call BookMore Details
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