Hotels in 77221 - Houston TX

Only hotels in 77221 zip code are listed below. Search for cheap and discount hotel rates in Houston, TX for your upcoming leisure or conference / group travel. We list the best 77221 hotels and motels so you can review the Houston hotel list below to find the perfect lodging. Hotels in Harris county and area code 713 are also listed.

77221 Hotels, Motels & Accommodations

Cliù Luxury Boutique Condo Hotel : 3144 Southmore Blvd. Unit 10
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
3144 Southmore Blvd. Unit 10, Houston, TX 77004 +1-888-389-4121 ~1.13 miles northwest of 77221
  • Four-star Downtown hotel
  • Check in time: 4:00pm CST
More Photos
From$100
Average 3.0 /5 Read Reviews Call BookMore Details
Extended Stay America Suites Houston Med Ctr Greenway Plaza : 2330 Southwest Frwy
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
2330 Southwest Frwy, Houston, TX 77098 +1-888-675-2083 ~1.16 miles west of 77221
  • Two star Downtown property
  • Check in time: 3:00 PM
More Photos
From$61
Average 3.0 /5 Latest Reviews Call BookMore Details
Summit Inn - Houston Medical Center in Houston
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
3138 Old Spanish Trail, Houston, TX 77054 +1-800-716-8490 ~1.37 miles west of 77221
  • Cheap property
  • Check in time: 11:00
More Photos
From$60
Average 3.0 /5 Recent Reviews Call BookMore Details
MainStay Suites Texas Medical Center/Reliant Park
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
3134 Old Spanish Trail, Houston, TX 77054 +1-800-805-5223 ~1.41 miles west of 77221
  • Economical Convention Center hotel
  • Gym / Fitness Center Available
More Photos
From$60
Very good 4.0 /5 Recent Reviews Call BookMore Details
Hilton University of Houston
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
4800 Calhoun Rd., Houston, TX 77004 +1-888-965-1860 ~1.54 miles northeast of 77221
  • 4 star Downtown hotel
  • Comp. Breakfast
More Photos
From$125
Average 3.0 /5 Recent Reviews Call BookMore Details
Americas Best Value Inn Medical Center Downtown : 2419 Riverside Dr.
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
2419 Riverside Dr., Houston, TX 77004 +1-888-788-5576 ~1.64 miles northwest of 77221
  • Low-priced hotel
  • Hotel has 2 floors
More Photos
From$60
Very good 4.0 /5 Recent Reviews Call BookMore Details
Home2 Suites : 6840 Almeda Rd.
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
6840 Almeda Rd., Houston, TX 77030 +1-888-897-9207 ~1.81 miles west of 77221
  • Three Star Suburban property
  • Has environment-friendly policy Read more
More Photos
From$99
Excellent 5.0 /5 Recent Reviews Call BookMore Details
Hilton Garden Inn - Houston
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
6840b Almeda Rd., Houston, TX 77030 +1-888-311-4278 ~1.81 miles west of 77221
  • Midscale Suburban property
  • Gym / Fitness Center Available
More Photos
From$109
Average 3.0 /5 Latest Reviews Call BookMore Details
Hilton Garden in Houston
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
6840 B Almeda Rd., Houston, TX 77030 +1-888-469-4795 ~1.82 miles west of 77221
  • Affordable hotel
More Photos
From$80
Average 3.0 /5 Guest Reviews Call BookMore Details
Medical District
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
2700 Old Spanish Trail, Houston, TX 77021 +1-888-734-9421 ~1.92 miles west of 77221
  • Expensive property
More Photos
From$75
Average 3.0 /5 Hotel Reviews Call BookMore Details
Sonder The Hampstead
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
1508 Blodgett, Houston, TX 77004 +1-888-841-5292 ~2.32 miles northwest of 77221
  • Three Star Downtown property
  • 36 suites in property
More Photos
From$80
Average 3.0 /5 Read Reviews Call BookMore Details
Scott Inn Suites Downtown Houston in Houston
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
1933 Scott St., Houston, TX 77003 +1-888-455-5160 ~2.34 miles north of 77221
  • Affordable hotel
  • Check-in: 15:00
More Photos
From$90
Very good 4.0 /5 Reviews Call BookMore Details
Best Way Inn Houston - Medical Center
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
3100 Holmes Rd., Houston, TX 77051 +1-888-965-8297 ~2.49 miles southwest of 77221
  • Economical property
  • Check-in time: 13:00
More Photos
From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
Extended Stay America Suites Houston Med Ctr Braeswood Bl - Houston
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
1301 Braeswood Blvd., Houston, TX 77030 +1-888-906-6358 ~2.52 miles west of 77221
  • Midscale Convention Center property
  • Hotel has 130 rooms
More Photos
From$64
Average 3.0 /5 Guest Reviews Call BookMore Details
Hotel Zaza Houston Museum District in Houston
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
5701 Main St., Houston, TX 77005 +1-888-749-6785 ~2.57 miles northwest of 77221
  • Four-star Downtown hotel
  • 12 floors in property
More Photos
From$159
Very good 4.5 /5 Reviews Call BookMore Details
Blossom Houston Medical Center - Houston
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
7114 Bertner Ave., Houston, TX 77030 +1-888-878-9982 ~2.68 miles west of 77221
  • 3 star property
  • Check in time: 16:00
More Photos
From$90
Very good 4.0 /5 Guest Reviews Call BookMore Details
Blossom Hotel Houston in Houston
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
7118 Bertner Ave., Houston, TX 77030 +1-888-389-4485 ~2.68 miles west of 77221
  • High end Convention Center property
  • Hotel has 267 rooms
More Photos
From$159
Average 3.0 /5 Hotel Reviews Call BookMore Details
Days Inn & Suites by Wyndham Downtown / University of Houston in Houston
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
6190 Gulf Freeway, Houston, TX 77023 +1-888-389-4121 ~2.72 miles east of 77221
  • Midscale Downtown hotel
  • Free breakfast available
More Photos
From$55
Average 3.0 /5 Recent Reviews Call BookMore Details
Lexington Hotel Houston Medical Center - Houston
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
1025 Swanson St., Houston, TX 77030 +1-888-675-2083 ~2.78 miles west of 77221
  • Low priced Downtown property
  • Check in: 3:00 PM
More Photos
From$60
Average 3.5 /5 Review Score Call BookMore Details
Hyatt Place
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
7329a Fannin St., Houston, TX 77030 +1-800-716-8490 ~2.78 miles west of 77221
  • 3-star property
More Photos
From$80
Average 3.0 /5 Latest Reviews Call BookMore Details
Hyatt Place Hyatt House Houston Medical Center
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
7329 Fannin St., Houston, TX 77030 +1-800-805-5223 ~2.78 miles west of 77221
  • Affordable Suburban hotel
  • Check in time: 3PM
More Photos
From$99
Average 3.0 /5 Hotel Reviews Call BookMore Details
Houston Marriott Medical Center/Museum District
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
6580 Fannin St., Houston, TX 77030 +1-888-965-1860 ~2.80 miles west of 77221
  • Expensive Downtown hotel
  • 26 floors in property
More Photos
From$75
Very good 4.5 /5 Hotel Reviews Call BookMore Details
The Westin Hou Medical Center - Houston
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
1709 Dryden Rd., Houston, TX 77030 +1-888-788-5576 ~2.81 miles west of 77221
  • Midscale property
  • Fitness + Health Center
More Photos
From$90
Very good 4.0 /5 Reviews Call BookMore Details
Sonder at Mid Main
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
3550 Main St., Houston, TX 77002 +1-888-897-9207 ~2.86 miles northwest of 77221
  • Affordable Downtown property
  • Hotel has 26 rooms
More Photos
From$75
Average 3.0 /5 Latest Reviews Call BookMore Details
Hampton Inn & Suites Houston Medical Center Nrg Park - Houston
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
1715 Old Spanish Trail, Houston, TX 77054 +1-888-311-4278 ~2.91 miles west of 77221
  • 3-star Convention Center property
  • Check in: 3:00PM
More Photos
From$69
Very good 4.0 /5 Review Score Call BookMore Details
Houston Medical Center Hotel : 6700 Main St.
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
6700 Main St., Houston, TX 77030 +1-888-469-4795 ~2.94 miles west of 77221
  • Affordable Downtown property
  • Hotel has 125 rooms
More Photos
From$115
Average 3.5 /5 Hotel Reviews Call BookMore Details
InterContinental Houston by IHG : 6750 Main St.
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
6750 Main St., Houston, TX 77030 +1-888-734-9421 ~2.98 miles west of 77221
  • 4-star Downtown property
  • Check-in: 15:00
More Photos
From$75
Average 3.0 /5 Guest Reviews Call BookMore Details
Doubletree by Hilton Houston Medical Center Hotel & Suites
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
6800 Main St., Houston, TX 77030 +1-888-841-5292 ~3.01 miles west of 77221
  • High end Downtown hotel
  • 12 floors in property
More Photos
From$125
Average 3.0 /5 Review Score Call BookMore Details
Extended Stay America - Houston - Med Ctr-NRG Park-Fannin
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
7979 Fannin, Houston, TX 77054 +1-888-455-5160 ~3.01 miles west of 77221
  • Cheap Convention Center property
  • Check in time: 3pm
More Photos
From$49
Poor 2.5 /5 Hotel Reviews Call BookMore Details
Holiday Inn Express Houston Downtown
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
1810 Bell St., Houston, TX 77003 +1-888-965-8297 ~3.10 miles north of 77221
  • Affordable Downtown property
  • Hotel has 22 suites
More Photos
From$80
Average 3.0 /5 Guest Reviews Call BookMore Details
Wanderstay Boutique Hotel - Houston
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
520 Sampson St., Houston, TX 77003 +1-888-906-6358 ~3.15 miles north of 77221
  • Expensive property
  • 2 suites in property
More Photos
From$125
Average 3.0 /5 Reviews Call BookMore Details
SpringHill Suites Houston Medical Center/NRG Park
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
1400 Old Spanish Trl, Houston, TX 77054 +1-888-749-6785 ~3.32 miles west of 77221
  • Three Star Downtown property
  • Fitness center on property
More Photos
From$80
Average 3.0 /5 Hotel Reviews Call BookMore Details
Whyhotel Houston Downtown : 1515 Austin St.
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
1515 Austin St., Houston, TX 77002 +1-888-878-9982 ~3.33 miles north of 77221
  • 3 star property
  • 103 sleeping rooms in hotel
More Photos
From$90
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Athens Hotel Suites : 1308 Clay St.
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
1308 Clay St., Houston, TX 77002 +1-888-389-4485 ~3.39 miles north of 77221
  • Affordable Downtown hotel
  • Fitness / Gym is on-site
More Photos
From$89
Average 3.0 /5 Guest Reviews Call BookMore Details
La Colombe D Or Hotel
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
3410 Montrose Blvd., Houston, TX 77006 +1-888-389-4121 ~3.40 miles northwest of 77221
  • Mid-scale property
  • 2 floors in hotel
More Photos
From$90
Average 3.0 /5 Read Reviews Call BookMore Details
Hilton Americas Houston in Houston
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
1600 Lamar St., Houston, TX 77010 +1-888-675-2083 ~3.40 miles north of 77221
  • Four star Downtown property
  • Check in time: 3:00 PM
More Photos
From$101
Very good 4.5 /5 Read Reviews Call BookMore Details
Hotel Saint Augustine - Houston
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
4110 Loretto Dr., Houston, TX 77006 +1-800-716-8490 ~3.41 miles northwest of 77221
  • 4-star Downtown property
More Photos
From$401
Average 3.0 /5 Recent Reviews Call BookMore Details
Embassy Suites Houston Downtown : 1515 Dallas
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
1515 Dallas, Houston, TX 77010 +1-800-805-5223 ~3.42 miles north of 77221
  • 3-star Downtown hotel
  • Hotel has 5 meeting rooms
More Photos
From$135
Very good 4.0 /5 Recent Reviews Call BookMore Details
Sonder Midtown
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
306 Mcgowen St., Houston, TX 77006 +1-888-965-1860 ~3.44 miles northwest of 77221
  • Mid-scale Downtown property
  • 6 floors in hotel
More Photos
From$75
Average 3.0 /5 Guest Reviews Call BookMore Details
Holiday Inn Houston Downtown by IHG in Houston
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
1616 Main St., Houston, TX 77002 +1-888-788-5576 ~3.46 miles north of 77221
  • Mid-scale Downtown hotel
  • 16 floors in property
More Photos
From$79
Poor 2.0 /5 Review Score Call BookMore Details
Marriott Marquis Houston
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
1777 Walker St., Houston, TX 77010 +1-888-897-9207 ~3.46 miles north of 77221
  • 4-star property
  • Check in time: 16:00
More Photos
From$375
Very good 4.0 /5 Guest Reviews Call BookMore Details
Courtyard by Marriott Houston Medical Center/NRG Park : Houston Medical Center 7702 Main St.
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
Houston Medical Center 7702 Main St., Houston, TX 77030 +1-888-311-4278 ~3.47 miles west of 77221
  • Mid-scale Suburban property
  • 3 meeting rooms in hotel
More Photos
From$69
Very good 4.0 /5 Guest Reviews Call BookMore Details
Sonder Lofts at Ballpark
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
610 St. Emanuel St. Houston Tx 77003, Houston, TX 77003 +1-888-469-4795 ~3.47 miles north of 77221
  • Midscale Downtown property
  • 6 floors in property
More Photos
From$100
Average 3.0 /5 Recent Reviews Call BookMore Details
The Reside
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
7755 South Main St., Houston, TX 77054 +1-888-734-9421 ~3.50 miles west of 77221
  • 3 star Downtown property
  • Hotel has an eco-friendly policy Learn more
More Photos
From$55
Very good 4.0 /5 Reviews Call BookMore Details
Holiday Inn Houston S - Nrg Area - Medical Center by IHG - Houston
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
8111 Kirby Dr., Houston, TX 77054 +1-888-841-5292 ~3.50 miles west of 77221
  • Mid-scale Suburban hotel
  • 6 suites in hotel
More Photos
From$126
Average 3.5 /5 Guest Reviews Call BookMore Details
Four Seasons Hotel Houston : 1300 Lamar St.
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
1300 Lamar St., Houston, TX 77010 +1-888-455-5160 ~3.51 miles north of 77221
  • Luxury 5-star Downtown property
  • Gym / Fitness Center Available
More Photos
From$275
Very good 4.0 /5 Guest Reviews Call BookMore Details
Extended Stay America Suites Houston Med Ctr NRG Park Kirby
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
1303 La Concha Ln, Houston, TX 77054 +1-888-965-8297 ~3.52 miles west of 77221
  • Cheap Convention Center property
  • Check in: 3pm
More Photos
From$41
Average 3.0 /5 Recent Reviews Call BookMore Details
Courtyard Houston Medical Center / Nrg Park
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
7702 Main St., Houston, TX 77030 +1-888-906-6358 ~3.55 miles west of 77221
  • 3 star Downtown property
  • 6 suites in property
More Photos
From$80
Average 3.0 /5 Review Score Call BookMore Details
Bayou City Event Center - Houston
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
9401 Knight Rd., Houston, TX 77045 +1-888-749-6785 ~3.55 miles southwest of 77221
  • Low Cost hotel
More Photos
From$60
Average 3.0 /5 Review Score Call BookMore Details
Residence Inn Houston Medical Center / Nrg Park in Houston
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
7807 Kirby Dr., Houston, TX 77030 +1-888-878-9982 ~3.56 miles west of 77221
  • Mid-scale Downtown hotel
  • Hotel has 4 meeting rooms
More Photos
From$109
Very good 4.0 /5 Latest Reviews Call BookMore Details
Back to Top