Hotels in 77221 - Houston TX

Only hotels in 77221 zip code are listed below. Search for cheap and discount hotel rates in Houston, TX for your upcoming leisure or conference / group travel. We list the best 77221 hotels and motels so you can review the Houston hotel list below to find the perfect lodging. Hotels in Harris county and area code 713 are also listed.

77221 Hotels/Accommodations

Cliù Luxury Boutique Condo Hotel 3144 Southmore Blvd. Unit 10, Houston, TX 77004 Call ~1.13 miles northwest of 77221
  • 4-star Downtown property
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From$100
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Extended Stay America Suites Houston Med Ctr Greenway Plaza - Houston 2330 Southwest Frwy, Houston, TX 77098 Call ~1.16 miles west of 77221
  • Low priced Downtown property
  • Hotel has 2 suites
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From$61
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Summit Inn - Houston Medical Center in Houston 3138 Old Spanish Trail, Houston, TX 77054 Call ~1.37 miles west of 77221
  • Cheap hotel
  • Check-in: 11:00
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From$60
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Mainstay Suites Texas Medical Center / Reliant Park 3134 Old Spanish Trail, Houston, TX 77054 Call ~1.41 miles west of 77221
  • 2 star Convention Center hotel
  • 89 rooms in hotel
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From$60
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Hilton University of Houston in Houston 4800 Calhoun Rd., Houston, TX 77004 Call ~1.54 miles northeast of 77221
  • High-end Downtown property
  • Hotel has 12 suites
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From$125
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Americas Best Value Inn Medical Center Downtown 2419 Riverside Dr., Houston, TX 77004 Call ~1.64 miles northwest of 77221
  • 2 star hotel
  • Check in time: 15:00
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From$60
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Home2 Suites : 6840 Almeda Rd. 6840 Almeda Rd., Houston, TX 77030 Call ~1.81 miles west of 77221
  • Three Star Suburban property
  • Hotel has a green policy Read more
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From$99
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Hilton Garden Inn - Houston 6840b Almeda Rd., Houston, TX 77030 Call ~1.81 miles west of 77221
  • Mid-scale Suburban property
  • Hotel has 36 suites
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From$109
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Hilton Garden in Houston 6840 B Almeda Rd., Houston, TX 77030 Call ~1.82 miles west of 77221
  • 3 star hotel
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From$80
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Medical District in Houston 2700 Old Spanish Trail, Houston, TX 77021 Call ~1.92 miles west of 77221
  • 4 star hotel
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Sonder The Hampstead in Houston 1508 Blodgett, Houston, TX 77004 Call ~2.32 miles northwest of 77221
  • 3 star Downtown hotel
  • Hotel has 36 rooms
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From$80
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Scott Inn Suites Downtown Houston : 1933 Scott St. 1933 Scott St., Houston, TX 77003 Call ~2.34 miles north of 77221
  • Three Star hotel
  • Hotel has 2 floors
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From$90
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Best Way Inn Houston - Medical Center 3100 Holmes Rd., Houston, TX 77051 Call ~2.49 miles southwest of 77221
  • 2 star hotel
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From$60
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Extended Stay America Suites Houston Med Ctr Braeswood Bl in Houston 1301 Braeswood Blvd., Houston, TX 77030 Call ~2.52 miles west of 77221
  • 3-star Convention Center property
  • 3 floors in hotel
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From$64
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Hotel Zaza Houston Museum District in Houston 5701 Main St., Houston, TX 77005 Call ~2.57 miles northwest of 77221
  • High-end Downtown hotel
  • Fitness / Gym is on-site
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From$159
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Blossom Houston Medical Center 7114 Bertner Ave., Houston, TX 77030 Call ~2.68 miles west of 77221
  • 3-star property
  • 230 sleeping rooms in hotel
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From$90
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Blossom Hotel Houston in Houston 7118 Bertner Ave., Houston, TX 77030 Call ~2.68 miles west of 77221
  • Four star Convention Center hotel
  • Check in time: 3:00PM
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From$169
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Days Inn & Suites by Wyndham Downtown / University of Houston 6190 Gulf Freeway, Houston, TX 77023 Call ~2.72 miles east of 77221
  • Three Star Downtown hotel
  • Access to gym on-site
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From$55
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Lexington Hotel Houston Medical Center 1025 Swanson St., Houston, TX 77030 Call ~2.78 miles west of 77221
  • Low Cost Downtown property
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From$60
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Hyatt Place - Houston 7329a Fannin St., Houston, TX 77030 Call ~2.78 miles west of 77221
  • 3 star hotel
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From$80
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Hyatt Place Hyatt House Houston Medical Center : 7329 Fannin St. 7329 Fannin St., Houston, TX 77030 Call ~2.78 miles west of 77221
  • Midscale Suburban hotel
  • Hotel has 298 rooms
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From$99
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Houston Marriott Medical Center/Museum District 6580 Fannin St., Houston, TX 77030 Call ~2.80 miles west of 77221
  • Four star Downtown hotel
  • Hotel has 386 rooms
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The Westin Hou Medical Center in Houston 1709 Dryden Rd., Houston, TX 77030 Call ~2.81 miles west of 77221
  • 3 star hotel
  • Check-in: 15:00
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Sonder at Mid Main : 3550 Main St. 3550 Main St., Houston, TX 77002 Call ~2.86 miles northwest of 77221
  • 3-star Downtown hotel
  • Fitness center on property
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Hampton Inn & Suites Houston Medical Center Nrg Park : 1715 Old Spanish Trail 1715 Old Spanish Trail, Houston, TX 77054 Call ~2.91 miles west of 77221
  • 3 star Convention Center hotel
  • Gym is available on property
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From$69
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Houston Medical Center Hotel in Houston 6700 Main St., Houston, TX 77030 Call ~2.94 miles west of 77221
  • Affordable Downtown hotel
  • Free comp. breakfast
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From$115
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InterContinental Houston by IHG 6750 Main St., Houston, TX 77030 Call ~2.98 miles west of 77221
  • 4-star Downtown property
  • Hotel has 354 rooms
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Doubletree by Hilton Houston Medical Center Hotel & Suites 6800 Main St., Houston, TX 77030 Call ~3.01 miles west of 77221
  • Four star Downtown hotel
  • Shuttle from airport available
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From$125
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Extended Stay America - Houston - Med Ctr-NRG Park-Fannin 7979 Fannin, Houston, TX 77054 Call ~3.01 miles west of 77221
  • Cheap Convention Center hotel
  • 3 floors in hotel
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From$49
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Holiday Inn Express Houston Downtown 1810 Bell St., Houston, TX 77003 Call ~3.10 miles north of 77221
  • Affordable Downtown hotel
  • 22 suites in hotel
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Wanderstay Boutique Hotel in Houston 520 Sampson St., Houston, TX 77003 Call ~3.15 miles north of 77221
  • 4-star hotel
  • 10 rooms in property
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From$125
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SpringHill Suites Houston Medical Center/NRG Park - Houston 1400 Old Spanish Trl, Houston, TX 77054 Call ~3.32 miles west of 77221
  • Mid-scale Downtown hotel
  • 7 floors in property
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From$80
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Whyhotel Houston Downtown 1515 Austin St., Houston, TX 77002 Call ~3.33 miles north of 77221
  • Affordable property
  • Hotel has 103 rooms
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From$90
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Athens Hotel Suites 1308 Clay St., Houston, TX 77002 Call ~3.39 miles north of 77221
  • Midscale Downtown hotel
  • 2 floors in hotel
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From$89
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La Colombe D Or Hotel 3410 Montrose Blvd., Houston, TX 77006 Call ~3.40 miles northwest of 77221
  • Three Star property
  • 15 rooms in hotel
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From$90
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Hilton Americas Houston - Houston 1600 Lamar St., Houston, TX 77010 Call ~3.40 miles north of 77221
  • High-end Downtown property
  • Check-in time: 3:00 PM
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From$101
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Hotel Saint Augustine 4110 Loretto Dr., Houston, TX 77006 Call ~3.41 miles northwest of 77221
  • Expensive Downtown property
  • 2 floors in property
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From$401
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Embassy Suites Houston Downtown in Houston 1515 Dallas, Houston, TX 77010 Call ~3.42 miles north of 77221
  • 3-star Downtown hotel
  • 5 conference rooms in property
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From$135
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Sonder Midtown 306 Mcgowen St., Houston, TX 77006 Call ~3.44 miles northwest of 77221
  • 3 star Downtown property
  • 11 suites in property
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Holiday Inn Houston Downtown by IHG : 1616 Main St. 1616 Main St., Houston, TX 77002 Call ~3.46 miles north of 77221
  • Three Star Downtown hotel
  • Check-in: 3:00 PM
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From$79
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Marriott Marquis Houston in Houston 1777 Walker St., Houston, TX 77010 Call ~3.46 miles north of 77221
  • High end hotel
  • Check-in time: 16:00
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From$375
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Courtyard by Marriott Houston Medical Center/NRG Park - Houston Houston Medical Center 7702 Main St., Houston, TX 77030 Call ~3.47 miles west of 77221
  • Three Star Suburban hotel
  • Check in: 3:00 PM
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From$69
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Sonder Lofts at Ballpark 610 St. Emanuel St. Houston Tx 77003, Houston, TX 77003 Call ~3.47 miles north of 77221
  • Midscale Downtown property
  • Hotel has 6 floors
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From$100
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The Reside 7755 South Main St., Houston, TX 77054 Call ~3.50 miles west of 77221
  • Affordable Downtown hotel
  • Fitness center on property
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From$55
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Holiday Inn Houston S - Nrg Area - Medical Center by IHG : 8111 Kirby Dr. 8111 Kirby Dr., Houston, TX 77054 Call ~3.50 miles west of 77221
  • Three Star Suburban property
  • 11 floors in hotel
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From$126
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Four Seasons Hotel Houston : 1300 Lamar St. 1300 Lamar St., Houston, TX 77010 Call ~3.51 miles north of 77221
  • Luxurious Five Star Downtown property
  • Fitness / Gym is on-site
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From$275
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Extended Stay America Suites Houston Med Ctr NRG Park Kirby 1303 La Concha Ln, Houston, TX 77054 Call ~3.52 miles west of 77221
  • Two star Convention Center property
  • 45 suites in property
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From$41
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Courtyard Houston Medical Center / Nrg Park 7702 Main St., Houston, TX 77030 Call ~3.55 miles west of 77221
  • Affordable Downtown property
  • Hotel has 8 floors
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From$80
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Bayou City Event Center in Houston 9401 Knight Rd., Houston, TX 77045 Call ~3.55 miles southwest of 77221
  • Two star hotel
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From$60
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Residence Inn Houston Medical Center / Nrg Park - Houston 7807 Kirby Dr., Houston, TX 77030 Call ~3.56 miles west of 77221
  • Affordable Downtown property
  • Check in time: 4:00 PM
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From$109
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