Hotels in 77221 - Houston TX

Only hotels in 77221 zip code are listed below. Search for cheap and discount hotel rates in Houston, TX for your upcoming leisure or conference / group travel. We list the best 77221 hotels and motels so you can review the Houston hotel list below to find the perfect lodging. Hotels in Harris county and area code 713 are also listed.

77221 Hotels/Motels & Accommodations

Cliù Luxury Boutique Condo Hotel in Houston
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
3144 Southmore Blvd. Unit 10, Houston, TX 77004 +1-888-389-4121 ~1.13 miles northwest of 77221
  • Four star Downtown hotel
  • Hotel has 2 floors
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From$100
Average 3.0 /5 Read Reviews Call BookMore Details
Extended Stay America Suites Houston Med Ctr Greenway Plaza
+1-888-675-2083

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New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
2330 Southwest Frwy, Houston, TX 77098 +1-888-675-2083 ~1.16 miles west of 77221
  • 2 star Downtown property
  • Gym / Fitness Center Available
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From$61
Average 3.0 /5 Latest Reviews Call BookMore Details
Summit Inn - Houston Medical Center
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
3138 Old Spanish Trail, Houston, TX 77054 +1-800-716-8490 ~1.37 miles west of 77221
  • 2-star hotel
  • 33 sleeping rooms in hotel
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From$60
Average 3.0 /5 Recent Reviews Call BookMore Details
MainStay Suites Texas Medical Center/Reliant Park
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
3134 Old Spanish Trail, Houston, TX 77054 +1-800-805-5223 ~1.41 miles west of 77221
  • Cheap Convention Center hotel
  • 89 sleeping rooms in hotel
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From$60
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Hilton University of Houston in Houston
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
4800 Calhoun Rd., Houston, TX 77004 +1-888-965-1860 ~1.54 miles northeast of 77221
  • 4-star Downtown hotel
  • 8 floors in property
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From$125
Average 3.0 /5 Review Score Call BookMore Details
Americas Best Value Inn Medical Center Downtown - Houston
+1-888-788-5576

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New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
2419 Riverside Dr., Houston, TX 77004 +1-888-788-5576 ~1.64 miles northwest of 77221
  • Low-priced hotel
  • Check in time: 15:00
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From$60
Very Good 4.0 /5 Reviews Call BookMore Details
Home2 Suites in Houston
+1-888-897-9207

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New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
6840 Almeda Rd., Houston, TX 77030 +1-888-897-9207 ~1.81 miles west of 77221
  • Mid-scale Suburban property
  • 143 rooms in property
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From$99
Excellent 5.0 /5 Hotel Reviews Call BookMore Details
Hilton Garden Inn
+1-888-311-4278

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New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
6840b Almeda Rd., Houston, TX 77030 +1-888-311-4278 ~1.81 miles west of 77221
  • 3 star Suburban property
  • 157 sleeping rooms in hotel
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From$109
Average 3.0 /5 Hotel Reviews Call BookMore Details
Hilton Garden : 6840 B Almeda Rd.
+1-888-469-4795

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New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
6840 B Almeda Rd., Houston, TX 77030 +1-888-469-4795 ~1.82 miles west of 77221
  • 3 star property
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From$80
Average 3.0 /5 Reviews Call BookMore Details
Medical District - Houston
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
2700 Old Spanish Trail, Houston, TX 77021 +1-888-734-9421 ~1.92 miles west of 77221
  • 4 star property
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From$75
Average 3.0 /5 Guest Reviews Call BookMore Details
Sonder The Hampstead : 1508 Blodgett
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
1508 Blodgett, Houston, TX 77004 +1-888-841-5292 ~2.32 miles northwest of 77221
  • Affordable Downtown property
  • 36 rooms in property
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From$80
Average 3.0 /5 Reviews Call BookMore Details
Scott Inn Suites Downtown Houston
+1-888-455-5160

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New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
1933 Scott St., Houston, TX 77003 +1-888-455-5160 ~2.34 miles north of 77221
  • Mid-scale property
  • 2 floors in hotel
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From$90
Very Good 4.0 /5 Review Score Call BookMore Details
Best Way Inn Houston - Medical Center
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
3100 Holmes Rd., Houston, TX 77051 +1-888-965-8297 ~2.49 miles southwest of 77221
  • Inexpensive property
  • Check in time: 13:00
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From$60
Average 3.0 /5 Reviews Call BookMore Details
Extended Stay America Suites Houston Med Ctr Braeswood Bl in Houston
+1-888-906-6358

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New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
1301 Braeswood Blvd., Houston, TX 77030 +1-888-906-6358 ~2.52 miles west of 77221
  • Three Star Convention Center hotel
  • 130 rooms in property
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From$64
Average 3.0 /5 Review Score Call BookMore Details
Hotel Zaza Houston Museum District : 5701 Main St.
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
5701 Main St., Houston, TX 77005 +1-888-749-6785 ~2.57 miles northwest of 77221
  • Four-star Downtown hotel
  • 12 floors in property
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From$159
Very Good 4.5 /5 Reviews Call BookMore Details
Blossom Houston Medical Center : 7114 Bertner Ave.
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
7114 Bertner Ave., Houston, TX 77030 +1-888-878-9982 ~2.68 miles west of 77221
  • Three Star property
  • 230 rooms in property
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From$90
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Blossom Hotel Houston : 7118 Bertner Ave.
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
7118 Bertner Ave., Houston, TX 77030 +1-888-389-4485 ~2.68 miles west of 77221
  • High-end Convention Center property
  • Check-in time: 3:00PM
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From$169
Average 3.0 /5 Read Reviews Call BookMore Details
Days Inn & Suites by Wyndham Downtown / University of Houston in Houston
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
6190 Gulf Freeway, Houston, TX 77023 +1-888-389-4121 ~2.72 miles east of 77221
  • Midscale Downtown hotel
  • 2 floors in hotel
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From$55
Average 3.0 /5 Hotel Reviews Call BookMore Details
Lexington Hotel Houston Medical Center
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
1025 Swanson St., Houston, TX 77030 +1-888-675-2083 ~2.78 miles west of 77221
  • Two-star Downtown property
  • Check in: 3:00 PM
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From$60
Average 3.5 /5 Guest Reviews Call BookMore Details
Hyatt Place : 7329a Fannin St.
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
7329a Fannin St., Houston, TX 77030 +1-800-716-8490 ~2.78 miles west of 77221
  • Affordable hotel
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From$80
Average 3.0 /5 Recent Reviews Call BookMore Details
Hyatt Place Hyatt House Houston Medical Center
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
7329 Fannin St., Houston, TX 77030 +1-800-805-5223 ~2.78 miles west of 77221
  • Mid-scale Suburban hotel
  • Free comp. breakfast
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From$99
Average 3.0 /5 Latest Reviews Call BookMore Details
Houston Marriott Medical Center/Museum District
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
6580 Fannin St., Houston, TX 77030 +1-888-965-1860 ~2.80 miles west of 77221
  • Four-star Downtown hotel
  • Hotel has 386 rooms
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From$75
Very Good 4.5 /5 Recent Reviews Call BookMore Details
The Westin Hou Medical Center
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
1709 Dryden Rd., Houston, TX 77030 +1-888-788-5576 ~2.81 miles west of 77221
  • Midscale property
  • Gym / Fitness Center Available
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From$90
Very Good 4.0 /5 Reviews Call BookMore Details
Sonder at Mid Main : 3550 Main St.
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
3550 Main St., Houston, TX 77002 +1-888-897-9207 ~2.86 miles northwest of 77221
  • Midscale Downtown hotel
  • Check in: 4:00 pm
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From$75
Average 3.0 /5 Recent Reviews Call BookMore Details
Hampton Inn & Suites Houston Medical Center Nrg Park
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
1715 Old Spanish Trail, Houston, TX 77054 +1-888-311-4278 ~2.91 miles west of 77221
  • Affordable Convention Center hotel
  • 3 meeting rooms in property
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From$69
Very Good 4.0 /5 Reviews Call BookMore Details
Houston Medical Center Hotel
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
6700 Main St., Houston, TX 77030 +1-888-469-4795 ~2.94 miles west of 77221
  • Three Star Downtown hotel
  • 6 floors in hotel
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From$115
Average 3.5 /5 Review Score Call BookMore Details
InterContinental Houston by IHG
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
6750 Main St., Houston, TX 77030 +1-888-734-9421 ~2.98 miles west of 77221
  • Four-star Downtown property
  • 21 floors in property
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From$75
Average 3.0 /5 Read Reviews Call BookMore Details
Doubletree by Hilton Houston Medical Center Hotel & Suites
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
6800 Main St., Houston, TX 77030 +1-888-841-5292 ~3.01 miles west of 77221
  • High-end Downtown hotel
  • Gym / Fitness Center Available
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From$125
Average 3.0 /5 Read Reviews Call BookMore Details
Extended Stay America - Houston - Med Ctr-NRG Park-Fannin
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
7979 Fannin, Houston, TX 77054 +1-888-455-5160 ~3.01 miles west of 77221
  • Low Cost Convention Center hotel
  • Check-in: 3pm
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From$49
Poor 2.5 /5 Guest Reviews Call BookMore Details
Holiday Inn Express Houston Downtown in Houston
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
1810 Bell St., Houston, TX 77003 +1-888-965-8297 ~3.10 miles north of 77221
  • 3-star Downtown property
  • Fitness center on property
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From$80
Average 3.0 /5 Hotel Reviews Call BookMore Details
Wanderstay Boutique Hotel : 520 Sampson St.
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
520 Sampson St., Houston, TX 77003 +1-888-906-6358 ~3.15 miles north of 77221
  • Four star property
  • 2 suites in hotel
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From$125
Average 3.0 /5 Recent Reviews Call BookMore Details
SpringHill Suites Houston Medical Center/NRG Park - Houston
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
1400 Old Spanish Trl, Houston, TX 77054 +1-888-749-6785 ~3.32 miles west of 77221
  • Affordable Downtown property
  • Check-in time: 3.00 pm
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From$80
Average 3.0 /5 Read Reviews Call BookMore Details
Whyhotel Houston Downtown in Houston
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
1515 Austin St., Houston, TX 77002 +1-888-878-9982 ~3.33 miles north of 77221
  • Three Star hotel
  • Check in: 15:00
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From$90
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Athens Hotel Suites - Houston
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
1308 Clay St., Houston, TX 77002 +1-888-389-4485 ~3.39 miles north of 77221
  • Midscale Downtown property
  • Check in time: 3PM
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From$89
Average 3.0 /5 Hotel Reviews Call BookMore Details
La Colombe D Or Hotel
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
3410 Montrose Blvd., Houston, TX 77006 +1-888-389-4121 ~3.40 miles northwest of 77221
  • Affordable hotel
  • Check-in time: 16:00
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From$90
Average 3.0 /5 Guest Reviews Call BookMore Details
Hilton Americas Houston
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
1600 Lamar St., Houston, TX 77010 +1-888-675-2083 ~3.40 miles north of 77221
  • 4-star Downtown hotel
  • Hotel has 24 floors
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From$101
Very Good 4.5 /5 Reviews Call BookMore Details
Hotel Saint Augustine in Houston
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
4110 Loretto Dr., Houston, TX 77006 +1-800-716-8490 ~3.41 miles northwest of 77221
  • Expensive Downtown property
  • Hotel has 71 rooms
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From$401
Average 3.0 /5 Hotel Reviews Call BookMore Details
Embassy Suites Houston Downtown : 1515 Dallas
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
1515 Dallas, Houston, TX 77010 +1-800-805-5223 ~3.42 miles north of 77221
  • 3-star Downtown property
  • 5 meeting rooms in property
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From$135
Very Good 4.0 /5 Review Score Call BookMore Details
Sonder Midtown in Houston
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
306 Mcgowen St., Houston, TX 77006 +1-888-965-1860 ~3.44 miles northwest of 77221
  • Mid-scale Downtown hotel
  • Check-in: 4:00 PM
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From$75
Average 3.0 /5 Read Reviews Call BookMore Details
Holiday Inn Houston Downtown by IHG
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
1616 Main St., Houston, TX 77002 +1-888-788-5576 ~3.46 miles north of 77221
  • Three Star Downtown hotel
  • 16 floors in property
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From$79
Poor 2.0 /5 Review Score Call BookMore Details
Marriott Marquis Houston
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
1777 Walker St., Houston, TX 77010 +1-888-897-9207 ~3.46 miles north of 77221
  • Four-star hotel
  • Hotel has 29 floors
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From$375
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Courtyard by Marriott Houston Medical Center/NRG Park in Houston
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
Houston Medical Center 7702 Main St., Houston, TX 77030 +1-888-311-4278 ~3.47 miles west of 77221
  • Mid-scale Suburban property
  • Fitness / Gym is on-site
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From$69
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Sonder Lofts at Ballpark - Houston
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
610 St. Emanuel St. Houston Tx 77003, Houston, TX 77003 +1-888-469-4795 ~3.47 miles north of 77221
  • 3 star Downtown property
  • Check in time: 4:00 PM
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From$100
Average 3.0 /5 Latest Reviews Call BookMore Details
The Reside in Houston
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
7755 South Main St., Houston, TX 77054 +1-888-734-9421 ~3.50 miles west of 77221
  • 3 star Downtown hotel
  • Hotel has 3 floors
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From$55
Very Good 4.0 /5 Reviews Call BookMore Details
Holiday Inn Houston S - Nrg Area - Medical Center by IHG
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
8111 Kirby Dr., Houston, TX 77054 +1-888-841-5292 ~3.50 miles west of 77221
  • Affordable Suburban property
  • Hotel has 6 suites
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From$126
Average 3.5 /5 Read Reviews Call BookMore Details
Four Seasons Hotel Houston
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
1300 Lamar St., Houston, TX 77010 +1-888-455-5160 ~3.51 miles north of 77221
  • Luxurious 5 Star Downtown hotel
  • Airport shuttle available
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From$275
Very Good 4.0 /5 Review Score Call BookMore Details
Extended Stay America Suites Houston Med Ctr NRG Park Kirby - Houston
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
1303 La Concha Ln, Houston, TX 77054 +1-888-965-8297 ~3.52 miles west of 77221
  • Economy Convention Center property
  • Free comp. breakfast
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From$41
Average 3.0 /5 Read Reviews Call BookMore Details
Courtyard Houston Medical Center / Nrg Park - Houston
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
7702 Main St., Houston, TX 77030 +1-888-906-6358 ~3.55 miles west of 77221
  • 3 star Downtown property
  • Hotel has 6 suites
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From$80
Average 3.0 /5 Review Score Call BookMore Details
Bayou City Event Center : 9401 Knight Rd.
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
9401 Knight Rd., Houston, TX 77045 +1-888-749-6785 ~3.55 miles southwest of 77221
  • Two star hotel
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From$60
Average 3.0 /5 Recent Reviews Call BookMore Details
Residence Inn Houston Medical Center / Nrg Park
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
7807 Kirby Dr., Houston, TX 77030 +1-888-878-9982 ~3.56 miles west of 77221
  • Affordable Downtown property
  • Hotel has 182 rooms
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From$109
Very Good 4.0 /5 Read Reviews Call BookMore Details
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