Hotels in 77221 - Houston TX

Only hotels in 77221 zip code are listed below. Search for cheap and discount hotel rates in Houston, TX for your upcoming leisure or conference / group travel. We list the best 77221 hotels and motels so you can review the Houston hotel list below to find the perfect lodging. Hotels in Harris county and area code 713 are also listed.

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77221 Hotels & Accommodations

Cliù Luxury Boutique Condo Hotel - Houston 3144 Southmore Blvd. Unit 10, Houston, TX 77004
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~1.13 miles northwest of 77221
  • High-end Downtown property
  • 16 rooms in hotel
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From$120 total
Average 3.0 /5 Latest Reviews Call BookMore Details
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Extended Stay America Suites Houston Med Ctr Greenway Plaza - Houston 2330 Southwest Frwy, Houston, TX 77098
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~1.16 miles west of 77221
  • Low-priced Downtown hotel
  • 2 suites in property
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From$73 total
Average 3.0 /5 Latest Reviews Call BookMore Details
Summit Inn - Houston Medical Center - Houston 3138 Old Spanish Trail, Houston, TX 77054
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~1.37 miles west of 77221
  • Cheap property
  • Check in time: 11:00
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From$72 total
Average 3.0 /5 Guest Reviews Call BookMore Details
Mainstay Suites Texas Medical Center / Reliant Park 3134 Old Spanish Trail, Houston, TX 77054
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~1.41 miles west of 77221
  • Economy Convention Center property
  • Check-in time: 11:00
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From$72 total
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Hilton University of Houston 4800 Calhoun Rd., Houston, TX 77004
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~1.54 miles northeast of 77221
  • 4-star Downtown property
  • Check-in: 3:00PM
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From$150 total
Average 3.0 /5 Reviews Call BookMore Details
Americas Best Value Inn Medical Center Downtown - Houston 2419 Riverside Dr., Houston, TX 77004
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~1.64 miles northwest of 77221
  • Low Cost hotel
  • 40 rooms in hotel
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From$72 total
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Hilton Garden Inn 6840b Almeda Rd., Houston, TX 77030
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~1.81 miles west of 77221
  • Midscale Suburban property
  • Hotel has an eco-friendly policy See more
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From$130 total
Average 3.0 /5 Latest Reviews Call BookMore Details
Home2 Suites in Houston 6840 Almeda Rd., Houston, TX 77030
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~1.81 miles west of 77221
  • 3-star Suburban hotel
  • Hotel has an eco-friendly policy See policy
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From$118 total
Excellent 5.0 /5 Read Reviews Call BookMore Details
Hilton Garden 6840 B Almeda Rd., Houston, TX 77030
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~1.82 miles west of 77221
  • Three Star property
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From$96 total
Average 3.0 /5 Recent Reviews Call BookMore Details
Medical District 2700 Old Spanish Trail, Houston, TX 77021
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~1.92 miles west of 77221
  • 4-star hotel
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From$90 total
Average 3.0 /5 Reviews Call BookMore Details
Sonder The Hampstead 1508 Blodgett, Houston, TX 77004
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~2.32 miles northwest of 77221
  • Mid-scale Downtown property
  • 36 rooms in hotel
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From$96 total
Average 3.0 /5 Hotel Reviews Call BookMore Details
Scott Inn Suites Downtown Houston : 1933 Scott St. 1933 Scott St., Houston, TX 77003
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~2.34 miles north of 77221
  • 3 star hotel
  • 2 floors in hotel
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From$108 total
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Best Way Inn Houston - Medical Center - Houston 3100 Holmes Rd., Houston, TX 77051
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~2.49 miles southwest of 77221
  • Low-priced property
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From$72 total
Average 3.0 /5 Reviews Call BookMore Details
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Extended Stay America Suites Houston Med Ctr Braeswood Bl in Houston 1301 Braeswood Blvd., Houston, TX 77030
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~2.52 miles west of 77221
  • 3-star Convention Center property
  • Hotel has 3 floors
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From$76 total
Average 3.0 /5 Guest Reviews Call BookMore Details
Hotel Zaza Houston Museum District 5701 Main St., Houston, TX 77005
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~2.57 miles northwest of 77221
  • Expensive Downtown hotel
  • Gym is available on property
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From$190 total
Very Good 4.5 /5 Recent Reviews Call BookMore Details
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Blossom Houston Medical Center 7114 Bertner Ave., Houston, TX 77030
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~2.68 miles west of 77221
  • Mid-scale hotel
  • Check in: 16:00
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From$108 total
Very Good 4.0 /5 Read Reviews Call BookMore Details
Blossom Hotel Houston 7118 Bertner Ave., Houston, TX 77030
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~2.68 miles west of 77221
  • High end Convention Center property
  • 37 suites in property
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From$202 total
Average 3.0 /5 Guest Reviews Call BookMore Details
Days Inn & Suites by Wyndham Downtown / University of Houston - Houston 6190 Gulf Freeway, Houston, TX 77023
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~2.72 miles east of 77221
  • Midscale Downtown property
  • Complimentary breakfast is offered
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From$66 total
Average 3.0 /5 Guest Reviews Call BookMore Details
Lexington Hotel Houston Medical Center 1025 Swanson St., Houston, TX 77030
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~2.78 miles west of 77221
  • Low priced Downtown hotel
  • Free comp. breakfast
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From$72 total
Average 3.5 /5 Review Score Call BookMore Details
Hyatt Place : 7329a Fannin St. 7329a Fannin St., Houston, TX 77030
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~2.78 miles west of 77221
  • 3 star hotel
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From$96 total
Average 3.0 /5 Read Reviews Call BookMore Details
Hyatt Place Hyatt House Houston Medical Center - Houston 7329 Fannin St., Houston, TX 77030
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~2.78 miles west of 77221
  • Affordable Suburban property
  • 3 conference rooms in property
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From$118 total
Average 3.0 /5 Hotel Reviews Call BookMore Details
Houston Marriott Medical Center/Museum District 6580 Fannin St., Houston, TX 77030
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~2.80 miles west of 77221
  • Four star Downtown property
  • 26 floors in hotel
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From$90 total
Very Good 4.5 /5 Read Reviews Call BookMore Details
The Westin Hou Medical Center 1709 Dryden Rd., Houston, TX 77030
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~2.81 miles west of 77221
  • Mid-scale property
  • Access to gym on-site
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From$108 total
Very Good 4.0 /5 Reviews Call BookMore Details
Sonder at Mid Main : 3550 Main St. 3550 Main St., Houston, TX 77002
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~2.86 miles northwest of 77221
  • Affordable Downtown property
  • Hotel has 12 suites
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From$90 total
Average 3.0 /5 Read Reviews Call BookMore Details
Hampton Inn & Suites Houston Medical Center Nrg Park 1715 Old Spanish Trail, Houston, TX 77054
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~2.91 miles west of 77221
  • Mid-scale Convention Center hotel
  • 3 conference rooms in property
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From$82 total
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Houston Medical Center Hotel in Houston 6700 Main St., Houston, TX 77030
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~2.94 miles west of 77221
  • Midscale Downtown hotel
  • 6 floors in property
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From$138 total
Average 3.5 /5 Read Reviews Call BookMore Details
InterContinental Houston by IHG - Houston 6750 Main St., Houston, TX 77030
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~2.98 miles west of 77221
  • Expensive Downtown property
  • Has environment-friendly policy Read more
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From$90 total
Average 3.0 /5 Review Score Call BookMore Details
Doubletree by Hilton Houston Medical Center Hotel & Suites in Houston 6800 Main St., Houston, TX 77030
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~3.01 miles west of 77221
  • High-end Downtown hotel
  • Has environment-friendly policy Learn more
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From$150 total
Average 3.0 /5 Hotel Reviews Call BookMore Details
Extended Stay America - Houston - Med Ctr-NRG Park-Fannin 7979 Fannin, Houston, TX 77054
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~3.01 miles west of 77221
  • Inexpensive Convention Center property
  • 153 rooms in property
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From$58 total
Poor 2.5 /5 Review Score Call BookMore Details
Best Western Premier Houston Downtown/Convention Center Hotel 1810 Bell St., Houston, TX 77003
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~3.12 miles north of 77221
  • 3 star Downtown hotel
  • Check in: 3:00pm
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From$96 total
Average 3.0 /5 Review Score Call BookMore Details
Wanderstay Boutique Hotel 520 Sampson St., Houston, TX 77003
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~3.15 miles north of 77221
  • Expensive property
  • Check-in time: 2:00PM CST
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From$150 total
Average 3.0 /5 Read Reviews Call BookMore Details
SpringHill Suites Houston Medical Center/NRG Park : 1400 Old Spanish Trl 1400 Old Spanish Trl, Houston, TX 77054
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~3.32 miles west of 77221
  • 3 star Downtown property
  • 190 suites in hotel
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From$96 total
Average 3.0 /5 Recent Reviews Call BookMore Details
Whyhotel Houston Downtown 1515 Austin St., Houston, TX 77002
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~3.33 miles north of 77221
  • Affordable property
  • 103 rooms in hotel
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From$108 total
Very Good 4.0 /5 Reviews Call BookMore Details
Athens Hotel Suites 1308 Clay St., Houston, TX 77002
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~3.39 miles north of 77221
  • Midscale Downtown hotel
  • Fitness / Gym is on-site
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From$106 total
Average 3.0 /5 Hotel Reviews Call BookMore Details
La Colombe D Or Hotel 3410 Montrose Blvd., Houston, TX 77006
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~3.40 miles northwest of 77221
  • Three Star hotel
  • 15 sleeping rooms in hotel
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From$108 total
Average 3.0 /5 Read Reviews Call BookMore Details
Hilton Americas Houston 1600 Lamar St., Houston, TX 77010
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~3.40 miles north of 77221
  • High-end Downtown hotel
  • Check-in: 3:00 PM
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From$121 total
Very Good 4.5 /5 Recent Reviews Call BookMore Details
Hotel Saint Augustine - Houston 4110 Loretto Dr., Houston, TX 77006
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~3.41 miles northwest of 77221
  • Four-star Downtown hotel
  • Check in: 3:00 PM
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From$481 total
Average 3.0 /5 Review Score Call BookMore Details
Embassy Suites Houston Downtown : 1515 Dallas St. 1515 Dallas St., Houston, TX 77002
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~3.42 miles north of 77221
  • Three Star Downtown property
  • 262 suites in property
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From$238 total
Average 3.0 /5 Guest Reviews Call BookMore Details
Embassy Suites by Hilton Houston Downtown Convention Center 1515 Dallas, Houston, TX 77010
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~3.42 miles north of 77221
  • 3 star Downtown hotel
  • 5 meeting rooms in hotel
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From$162 total
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Sonder Midtown 306 Mcgowen St., Houston, TX 77006
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~3.44 miles northwest of 77221
  • 3 star Downtown property
  • Check in: 4:00 PM
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From$90 total
Average 3.0 /5 Guest Reviews Call BookMore Details
Holiday Inn Houston Downtown by IHG - Houston 1616 Main St., Houston, TX 77002
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~3.46 miles north of 77221
  • Affordable Downtown hotel
  • Check-in: 3:00 PM
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From$94 total
Poor 2.0 /5 Guest Reviews Call BookMore Details
Marriott Marquis Houston 1777 Walker St., Houston, TX 77010
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~3.46 miles north of 77221
  • 4 star property
  • Check-in: 16:00
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From$450 total
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Courtyard by Marriott Houston Medical Center/NRG Park : Houston Medical Center 7702 Main St. Houston Medical Center 7702 Main St., Houston, TX 77030
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~3.47 miles west of 77221
  • 3 star Suburban property
  • Fitness center on property
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From$82 total
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Sonder Lofts at Ballpark : 610 St. Emanuel St. Houston Tx 77003 610 St. Emanuel St. Houston Tx 77003, Houston, TX 77003
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~3.47 miles north of 77221
  • Affordable Downtown property
  • Hotel has 6 floors
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From$120 total
Average 3.0 /5 Guest Reviews Call BookMore Details
The Reside 7755 South Main St., Houston, TX 77054
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~3.50 miles west of 77221
  • Midscale Downtown hotel
  • 3 floors in hotel
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From$66 total
Very Good 4.0 /5 Reviews Call BookMore Details
Holiday Inn Houston S - Nrg Area - Medical Center by IHG 8111 Kirby Dr., Houston, TX 77054
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~3.50 miles west of 77221
  • 3 star Suburban property
  • Check-in time: 3:00 PM
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From$151 total
Average 3.5 /5 Recent Reviews Call BookMore Details
Four Seasons Hotel Houston in Houston 1300 Lamar St., Houston, TX 77010
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~3.51 miles north of 77221
  • Luxury 5 star Downtown hotel
  • Check in time: 3:00 p.m.
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From$330 total
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Extended Stay America Suites Houston Med Ctr NRG Park Kirby in Houston 1303 La Concha Ln, Houston, TX 77054
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~3.52 miles west of 77221
  • 2 star Convention Center property
  • Comp. Breakfast
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From$49 total
Average 3.0 /5 Latest Reviews Call BookMore Details
Courtyard Houston Medical Center / Nrg Park in Houston 7702 Main St., Houston, TX 77030
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~3.55 miles west of 77221
  • Affordable Downtown property
  • Hotel has an eco-friendly policy See more
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From$96 total
Average 3.0 /5 Latest Reviews Call BookMore Details
Bayou City Event Center in Houston 9401 Knight Rd., Houston, TX 77045
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~3.55 miles southwest of 77221
  • Cheap property
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From$72 total
Average 3.0 /5 Recent Reviews Call BookMore Details

Next: Show All Available 77221 Hotels with Pricing

Graph: Upcoming 20 Days of Houston Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Houston, TX discounts available. The chart reflects the cheapest Houston hotel for each day and each star rating category.

FAQs about hotels near 77221

What are the most favored hotels near 77221?

Home2 Suites, Hotel Zaza Houston Museum District and Houston Marriott Medical Center are the best rated hotels based on customer reviews in the last 365 days.

What are the most luxurious hotels near 77221?

Four Seasons Hotel Houston, Cliù Luxury Boutique Condo Hotel and Hilton University of Houston are the top 3 luxury hotels near 77221.

What hotels are closest to the area of 77221?

Cliù Luxury Boutique Condo Hotel, Extended Stay America Suites Houston Med Ctr Greenway Plaza, and Summit Inn - Houston Medical Center are the properties closest to 77221.

How much does a cheap hotel near 77221 cost per night?

In the last year, a 2 star hotel near 77221 can be as cheap as $63.37 per night. (based on HotelPlanner prices)

How much does a 3 star hotel near 77221 cost per night?

In the last year, the average 3 star hotel near 77221 has been $85.49 per night. (based on HotelPlanner prices)

How much does a 4-5 star hotel near 77221 cost?

In the last year, the average 4 star hotel near 77221 has been $111.54 per night. (based on HotelPlanner prices)

What are the best independent hotels near 77221?

Hotel Zaza Houston Museum District, Scott Inn Suites Downtown Houston and Blossom Houston Medical Center are the best rated independent hotels (not part of a big brand).

What are the most popular Marriott hotels near 77221?

Houston Marriott Medical Center, The Westin Hou Medical Center and Marriott Marquis Houston are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the best IHG hotels near 77221?

Holiday Inn Houston S - Nrg Area - Medical Center by IHG, Holiday Inn Houston Downtown by IHG and InterContinental Houston by IHG are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

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