Hotels in 77221 - Houston TX

Only hotels in 77221 zip code are listed below. Search for cheap and discount hotel rates in Houston, TX for your upcoming leisure or conference / group travel. We list the best 77221 hotels and motels so you can review the Houston hotel list below to find the perfect lodging. Hotels in Harris county and area code 713 are also listed.

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77221 Hotels & Accommodations

Cliù Luxury Boutique Condo Hotel 3144 Southmore Blvd. Unit 10, Houston, TX 77004
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~1.13 miles northwest of 77221
  • High end Downtown hotel
  • 8 suites in property
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From$100
Average 3.0 /5 Recent Reviews Call BookMore Details
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Extended Stay America Suites Houston Med Ctr Greenway Plaza : 2330 Southwest Frwy 2330 Southwest Frwy, Houston, TX 77098
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~1.16 miles west of 77221
  • Economy Downtown property
  • Hotel has 3 floors
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From$61
Average 3.0 /5 Recent Reviews Call BookMore Details
Summit Inn - Houston Medical Center - Houston 3138 Old Spanish Trail, Houston, TX 77054
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~1.37 miles west of 77221
  • Two star hotel
  • Check in time: 11:00
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From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
Mainstay Suites Texas Medical Center / Reliant Park 3134 Old Spanish Trail, Houston, TX 77054
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~1.41 miles west of 77221
  • Inexpensive Convention Center property
  • Fitness / Gym is on-site
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From$60
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Hilton University of Houston 4800 Calhoun Rd., Houston, TX 77004
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~1.54 miles northeast of 77221
  • 4-star Downtown property
  • Check-in: 3:00PM
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From$125
Average 3.0 /5 Read Reviews Call BookMore Details
Americas Best Value Inn Medical Center Downtown in Houston 2419 Riverside Dr., Houston, TX 77004
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~1.64 miles northwest of 77221
  • Two star hotel
  • Hotel has 40 rooms
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From$60
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Home2 Suites 6840 Almeda Rd., Houston, TX 77030
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~1.81 miles west of 77221
  • 3 star Suburban property
  • Gym / Fitness Center Available
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From$99
Excellent 5.0 /5 Guest Reviews Call BookMore Details
Hilton Garden Inn : 6840b Almeda Rd. 6840b Almeda Rd., Houston, TX 77030
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~1.81 miles west of 77221
  • Affordable Suburban hotel
  • 157 sleeping rooms in hotel
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From$109
Average 3.0 /5 Recent Reviews Call BookMore Details
Hilton Garden 6840 B Almeda Rd., Houston, TX 77030
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~1.82 miles west of 77221
  • 3-star hotel
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From$80
Average 3.0 /5 Review Score Call BookMore Details
Medical District : 2700 Old Spanish Trail 2700 Old Spanish Trail, Houston, TX 77021
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~1.92 miles west of 77221
  • High-end hotel
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From$75
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Sonder The Hampstead 1508 Blodgett, Houston, TX 77004
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~2.32 miles northwest of 77221
  • 3-star Downtown property
  • 36 suites in hotel
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From$80
Average 3.0 /5 Hotel Reviews Call BookMore Details
Scott Inn Suites Downtown Houston : 1933 Scott St. 1933 Scott St., Houston, TX 77003
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~2.34 miles north of 77221
  • 3-star hotel
  • 18 rooms in property
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From$90
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Best Way Inn Houston - Medical Center - Houston 3100 Holmes Rd., Houston, TX 77051
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~2.49 miles southwest of 77221
  • 2-star hotel
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From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
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Extended Stay America Suites Houston Med Ctr Braeswood Bl : 1301 Braeswood Blvd. 1301 Braeswood Blvd., Houston, TX 77030
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~2.52 miles west of 77221
  • Affordable Convention Center property
  • Hotel has 4 suites
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From$64
Average 3.0 /5 Reviews Call BookMore Details
Hotel Zaza Houston Museum District 5701 Main St., Houston, TX 77005
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~2.57 miles northwest of 77221
  • 4 star Downtown hotel
  • Check in: 4:00 PM
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From$159
Very Good 4.5 /5 Read Reviews Call BookMore Details
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Blossom Houston Medical Center : 7114 Bertner Ave. 7114 Bertner Ave., Houston, TX 77030
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~2.68 miles west of 77221
  • 3 star property
  • 230 sleeping rooms in hotel
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From$90
Very Good 4.0 /5 Reviews Call BookMore Details
Blossom Hotel Houston 7118 Bertner Ave., Houston, TX 77030
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~2.68 miles west of 77221
  • 4-star Convention Center property
  • 267 rooms in hotel
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From$169
Average 3.0 /5 Reviews Call BookMore Details
Days Inn & Suites by Wyndham Downtown / University of Houston - Houston 6190 Gulf Freeway, Houston, TX 77023
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~2.72 miles east of 77221
  • 3-star Downtown hotel
  • Check in: 2:00pm
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From$55
Average 3.0 /5 Hotel Reviews Call BookMore Details
Lexington Hotel Houston Medical Center 1025 Swanson St., Houston, TX 77030
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~2.78 miles west of 77221
  • Two-star Downtown property
  • Check-in: 3:00 PM
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From$60
Average 3.5 /5 Read Reviews Call BookMore Details
Hyatt Place 7329a Fannin St., Houston, TX 77030
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~2.78 miles west of 77221
  • 3 star hotel
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From$80
Average 3.0 /5 Recent Reviews Call BookMore Details
Hyatt Place Hyatt House Houston Medical Center 7329 Fannin St., Houston, TX 77030
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~2.78 miles west of 77221
  • 3 star Suburban property
  • Hotel has 129 suites
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From$99
Average 3.0 /5 Latest Reviews Call BookMore Details
Houston Marriott Medical Center/Museum District : 6580 Fannin St. 6580 Fannin St., Houston, TX 77030
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~2.80 miles west of 77221
  • Expensive Downtown property
  • Check in time: 1pm
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From$75
Very Good 4.5 /5 Latest Reviews Call BookMore Details
The Westin Hou Medical Center - Houston 1709 Dryden Rd., Houston, TX 77030
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~2.81 miles west of 77221
  • Affordable hotel
  • Check in: 15:00
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From$90
Very Good 4.0 /5 Read Reviews Call BookMore Details
Sonder at Mid Main - Houston 3550 Main St., Houston, TX 77002
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~2.86 miles northwest of 77221
  • 3-star Downtown property
  • 2 meeting rooms in property
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From$75
Average 3.0 /5 Review Score Call BookMore Details
Hampton Inn & Suites Houston Medical Center Nrg Park in Houston 1715 Old Spanish Trail, Houston, TX 77054
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~2.91 miles west of 77221
  • Three Star Convention Center property
  • Complimentary breakfast is offered
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From$69
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Houston Medical Center Hotel 6700 Main St., Houston, TX 77030
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~2.94 miles west of 77221
  • Affordable Downtown property
  • Hotel has an eco-friendly policy Read more
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From$115
Average 3.5 /5 Recent Reviews Call BookMore Details
InterContinental Houston by IHG in Houston 6750 Main St., Houston, TX 77030
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~2.98 miles west of 77221
  • High-end Downtown hotel
  • 37 suites in hotel
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From$75
Average 3.0 /5 Review Score Call BookMore Details
Doubletree by Hilton Houston Medical Center Hotel & Suites 6800 Main St., Houston, TX 77030
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~3.01 miles west of 77221
  • Four star Downtown hotel
  • Hotel has 297 rooms
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From$125
Average 3.0 /5 Guest Reviews Call BookMore Details
Extended Stay America - Houston - Med Ctr-NRG Park-Fannin : 7979 Fannin 7979 Fannin, Houston, TX 77054
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~3.01 miles west of 77221
  • Cheap Convention Center property
  • 153 rooms in hotel
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From$49
Poor 2.5 /5 Guest Reviews Call BookMore Details
Holiday Inn Express Houston Downtown 1810 Bell St., Houston, TX 77003
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~3.10 miles north of 77221
  • 3-star Downtown hotel
  • Fitness center on property
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From$80
Average 3.0 /5 Guest Reviews Call BookMore Details
Wanderstay Boutique Hotel 520 Sampson St., Houston, TX 77003
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~3.15 miles north of 77221
  • Expensive property
  • Check in time: 2:00PM CST
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From$125
Average 3.0 /5 Guest Reviews Call BookMore Details
SpringHill Suites Houston Medical Center/NRG Park in Houston 1400 Old Spanish Trl, Houston, TX 77054
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~3.32 miles west of 77221
  • Affordable Downtown hotel
  • Hotel has 190 suites
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From$80
Average 3.0 /5 Recent Reviews Call BookMore Details
Whyhotel Houston Downtown 1515 Austin St., Houston, TX 77002
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~3.33 miles north of 77221
  • 3 star property
  • 103 rooms in hotel
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From$90
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Athens Hotel Suites : 1308 Clay St. 1308 Clay St., Houston, TX 77002
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~3.39 miles north of 77221
  • 3-star Downtown property
  • Check in time: 3PM
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From$89
Average 3.0 /5 Hotel Reviews Call BookMore Details
La Colombe D Or Hotel 3410 Montrose Blvd., Houston, TX 77006
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~3.40 miles northwest of 77221
  • Affordable property
  • 2 floors in hotel
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From$90
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Hilton Americas Houston 1600 Lamar St., Houston, TX 77010
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~3.40 miles north of 77221
  • High end Downtown property
  • Access to gym on-site
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From$101
Very Good 4.5 /5 Latest Reviews Call BookMore Details
Hotel Saint Augustine : 4110 Loretto Dr. 4110 Loretto Dr., Houston, TX 77006
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~3.41 miles northwest of 77221
  • 4 star Downtown hotel
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From$401
Average 3.0 /5 Read Reviews Call BookMore Details
Embassy Suites Houston Downtown in Houston 1515 Dallas, Houston, TX 77010
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~3.42 miles north of 77221
  • 3 star Downtown property
  • Gym / Fitness Center Available
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From$135
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Sonder Midtown 306 Mcgowen St., Houston, TX 77006
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~3.44 miles northwest of 77221
  • Midscale Downtown hotel
  • Fitness / Gym is on-site
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From$75
Average 3.0 /5 Latest Reviews Call BookMore Details
Holiday Inn Houston Downtown by IHG : 1616 Main St. 1616 Main St., Houston, TX 77002
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~3.46 miles north of 77221
  • Three Star Downtown hotel
  • Hotel has 20 suites
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From$79
Poor 2.0 /5 Read Reviews Call BookMore Details
Marriott Marquis Houston 1777 Walker St., Houston, TX 77010
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~3.46 miles north of 77221
  • Expensive hotel
  • Check in: 16:00
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From$375
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Courtyard by Marriott Houston Medical Center/NRG Park Houston Medical Center 7702 Main St., Houston, TX 77030
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~3.47 miles west of 77221
  • Affordable Suburban property
  • Gym is available on property
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From$69
Very Good 4.0 /5 Read Reviews Call BookMore Details
Sonder Lofts at Ballpark : 610 St. Emanuel St. Houston Tx 77003 610 St. Emanuel St. Houston Tx 77003, Houston, TX 77003
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~3.47 miles north of 77221
  • 3-star Downtown hotel
  • 22 rooms in hotel
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From$100
Average 3.0 /5 Reviews Call BookMore Details
The Reside 7755 South Main St., Houston, TX 77054
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~3.50 miles west of 77221
  • Affordable Downtown hotel
  • Hotel has 36 rooms
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From$55
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Holiday Inn Houston S - Nrg Area - Medical Center by IHG - Houston 8111 Kirby Dr., Houston, TX 77054
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~3.50 miles west of 77221
  • Midscale Suburban hotel
  • 6 suites in property
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From$126
Average 3.5 /5 Review Score Call BookMore Details
Four Seasons Hotel Houston : 1300 Lamar St. 1300 Lamar St., Houston, TX 77010
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~3.51 miles north of 77221
  • Luxurious 5 Star Downtown hotel
  • Access to gym on-site
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From$275
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Extended Stay America Suites Houston Med Ctr NRG Park Kirby 1303 La Concha Ln, Houston, TX 77054
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~3.52 miles west of 77221
  • Cheap Convention Center hotel
  • Gym / Fitness Center Available
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From$41
Average 3.0 /5 Read Reviews Call BookMore Details
Courtyard Houston Medical Center / Nrg Park 7702 Main St., Houston, TX 77030
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~3.55 miles west of 77221
  • Three Star Downtown hotel
  • 197 sleeping rooms in hotel
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From$80
Average 3.0 /5 Hotel Reviews Call BookMore Details
Bayou City Event Center : 9401 Knight Rd. 9401 Knight Rd., Houston, TX 77045
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~3.55 miles southwest of 77221
  • Low-priced property
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From$60
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Residence Inn Houston Medical Center / Nrg Park : 7807 Kirby Dr. 7807 Kirby Dr., Houston, TX 77030
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~3.56 miles west of 77221
  • Midscale Downtown hotel
  • 182 rooms in hotel
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From$109
Very Good 4.0 /5 Hotel Reviews Call BookMore Details

Next: Show All Available 77221 Hotels with Pricing

Graph: Upcoming 20 Days of Houston Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Houston, TX discounts available. The chart reflects the cheapest Houston hotel for each day and each star rating category.

FAQs about hotels near 77221

What are the most favored hotels near 77221?

Home2 Suites, Hotel Zaza Houston Museum District and Houston Marriott Medical Center are the best rated hotels based on customer reviews in the last 365 days.

What are the most luxurious hotels near 77221?

Four Seasons Hotel Houston, Cliù Luxury Boutique Condo Hotel and Hilton University of Houston are the top 3 luxury hotels near 77221.

What hotels are closest to the area of 77221?

Cliù Luxury Boutique Condo Hotel, Extended Stay America Suites Houston Med Ctr Greenway Plaza, and Summit Inn - Houston Medical Center are the properties closest to 77221.

How much does a cheap hotel near 77221 cost per night?

In the last year, a 2 star hotel near 77221 can be as cheap as $63.37 per night. (based on HotelPlanner prices)

How much does a 3 star hotel near 77221 cost per night?

In the last year, the average 3 star hotel near 77221 has been $85.49 per night. (based on HotelPlanner prices)

How much does a 4-5 star hotel near 77221 cost?

In the last year, the average 4 star hotel near 77221 has been $111.54 per night. (based on HotelPlanner prices)

What are the best independent hotels near 77221?

Hotel Zaza Houston Museum District, Scott Inn Suites Downtown Houston and Blossom Houston Medical Center are the best rated independent hotels (not part of a big brand).

What are the most popular Marriott hotels near 77221?

Houston Marriott Medical Center, The Westin Hou Medical Center and Marriott Marquis Houston are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the best IHG hotels near 77221?

Holiday Inn Houston S - Nrg Area - Medical Center by IHG, Holiday Inn Houston Downtown by IHG and InterContinental Houston by IHG are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

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