Hotels in 77221 - Houston TX

Only hotels in 77221 zip code are listed below. Search for cheap and discount hotel rates in Houston, TX for your upcoming leisure or conference / group travel. We list the best 77221 hotels and motels so you can review the Houston hotel list below to find the perfect lodging. Hotels in Harris county and area code 713 are also listed.

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77221 Hotels/Accommodations

Cliù Luxury Boutique Condo Hotel - Houston
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
3144 Southmore Blvd. Unit 10, Houston, TX 77004 ~1.13 miles northwest of 77221
  • 4-star Downtown property
  • 16 rooms in property
More Photos Photo of Cliù Luxury Boutique Condo Hotel
From$100
Average 3.0 /5 Reviews Call BookMore Details
Tired of clicking around? Talk to an expert Hotel Planner: (855) 276-7561 or say...
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Extended Stay America Suites Houston Med Ctr Greenway Plaza in Houston
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
2330 Southwest Frwy, Houston, TX 77098 ~1.16 miles west of 77221
  • Economical Downtown property
  • Complimentary breakfast is offered
More Photos Image of Extended Stay America Suites Houston Med Ctr Greenway Plaza
From$61
Average 3.0 /5 Hotel Reviews Call BookMore Details
Summit Inn - Houston Medical Center - Houston
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
3138 Old Spanish Trail, Houston, TX 77054 ~1.37 miles west of 77221
  • Cheap hotel
  • 33 rooms in property
More Photos Photo of Summit Inn - Houston Medical Center
From$60
Average 3.0 /5 Read Reviews Call BookMore Details
MainStay Suites Texas Medical Center/Reliant Park - Houston
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
3134 Old Spanish Trail, Houston, TX 77054 ~1.41 miles west of 77221
  • Cheap Convention Center hotel
  • Fitness / Gym is on-site
More Photos Photo of MainStay Suites Texas Medical Center/Reliant Park
From$60
Very Good 4.0 /5 Reviews Call BookMore Details
Hilton University of Houston
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
4800 Calhoun Rd., Houston, TX 77004 ~1.54 miles northeast of 77221
  • Four star Downtown property
  • Check-in time: 3:00PM
More Photos Exterior of Hilton University of Houston
From$125
Average 3.0 /5 Hotel Reviews Call BookMore Details
Americas Best Value Inn Medical Center Downtown - Houston
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
2419 Riverside Dr., Houston, TX 77004 ~1.64 miles northwest of 77221
  • Low priced property
  • Comp. Breakfast
More Photos Photo of Americas Best Value Inn Medical Center Downtown
From$60
Very Good 4.0 /5 Reviews Call BookMore Details
Home2 Suites
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
6840 Almeda Rd., Houston, TX 77030 ~1.81 miles west of 77221
  • 3 star Suburban hotel
  • Check in time: 4:00 PM
More Photos Exterior of Home2 Suites
From$99
Excellent 5.0 /5 Guest Reviews Call BookMore Details
Hilton Garden Inn
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
6840b Almeda Rd., Houston, TX 77030 ~1.81 miles west of 77221
  • Mid-scale Suburban hotel
  • Access to gym on-site
More Photos Photo of Hilton Garden Inn
From$109
Average 3.0 /5 Review Score Call BookMore Details
Hilton Garden in Houston
+1-888-469-4795

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New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
6840 B Almeda Rd., Houston, TX 77030 ~1.82 miles west of 77221
  • 3-star hotel
More Photos hotel room
From$80
Average 3.0 /5 Read Reviews Call BookMore Details
Medical District : 2700 Old Spanish Trail
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
2700 Old Spanish Trail, Houston, TX 77021 ~1.92 miles west of 77221
  • Four star property
More Photos hotel room
From$75
Average 3.0 /5 Read Reviews Call BookMore Details
Sonder The Hampstead - Houston
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
1508 Blodgett, Houston, TX 77004 ~2.32 miles northwest of 77221
  • 3-star Downtown property
  • 4 floors in hotel
More Photos Photo of Sonder The Hampstead
From$80
Average 3.0 /5 Recent Reviews Call BookMore Details
Scott Inn Suites Downtown Houston
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
1933 Scott St., Houston, TX 77003 ~2.34 miles north of 77221
  • Three Star property
  • 18 rooms in hotel
More Photos hotel room
From$90
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Best Way Inn Houston - Medical Center : 3100 Holmes Rd.
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
3100 Holmes Rd., Houston, TX 77051 ~2.49 miles southwest of 77221
  • Low-priced property
  • Check in: 13:00
More Photos Exterior of Best Way Inn Houston - Medical Center
From$60
Average 3.0 /5 Hotel Reviews Call BookMore Details
More Homes & Apts at Booking.com

Book online or call +1-800-219-2797

Booking for Homes and Apartments
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Extended Stay America Suites Houston Med Ctr Braeswood Bl : 1301 Braeswood Blvd.
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
1301 Braeswood Blvd., Houston, TX 77030 ~2.52 miles west of 77221
  • Affordable Convention Center property
  • 130 rooms in property
More Photos Image of Extended Stay America Suites Houston Med Ctr Braeswood Bl
From$64
Average 3.0 /5 Reviews Call BookMore Details
Hotel Zaza Houston Museum District - Houston
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
5701 Main St., Houston, TX 77005 ~2.57 miles northwest of 77221
  • Four star Downtown hotel
  • Check in: 4:00 PM
More Photos Image of Hotel Zaza Houston Museum District
From$159
Very Good 4.5 /5 Guest Reviews Call BookMore Details
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Blossom Houston Medical Center in Houston
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
7114 Bertner Ave., Houston, TX 77030 ~2.68 miles west of 77221
  • Three Star hotel
  • Hotel has 230 rooms
More Photos hotel room
From$90
Very Good 4.0 /5 Read Reviews Call BookMore Details
Blossom Hotel Houston - Houston
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
7118 Bertner Ave., Houston, TX 77030 ~2.68 miles west of 77221
  • Expensive Convention Center hotel
  • Hotel has 267 rooms
More Photos Exterior of Blossom Hotel Houston
From$159
Average 3.0 /5 Hotel Reviews Call BookMore Details
Days Inn & Suites by Wyndham Downtown / University of Houston - Houston
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
6190 Gulf Freeway, Houston, TX 77023 ~2.72 miles east of 77221
  • Midscale Downtown hotel
  • Complimentary breakfast is offered
More Photos Photo of Days Inn & Suites by Wyndham Downtown / University of Houston
From$55
Average 3.0 /5 Recent Reviews Call BookMore Details
Lexington Hotel Houston Medical Center in Houston
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
1025 Swanson St., Houston, TX 77030 ~2.78 miles west of 77221
  • 2 star Downtown hotel
  • Free complimentary breakfast
More Photos Photo of Lexington Hotel Houston Medical Center
From$60
Average 3.5 /5 Latest Reviews Call BookMore Details
Hyatt Place
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
7329a Fannin St., Houston, TX 77030 ~2.78 miles west of 77221
  • Mid-scale property
More Photos hotel room
From$80
Average 3.0 /5 Guest Reviews Call BookMore Details
Hyatt Place Hyatt House Houston Medical Center
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
7329 Fannin St., Houston, TX 77030 ~2.78 miles west of 77221
  • Midscale Suburban property
  • Hotel has 298 rooms
More Photos Exterior of Hyatt Place Hyatt House Houston Medical Center
From$99
Average 3.0 /5 Reviews Call BookMore Details
Houston Marriott Medical Center/Museum District
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
6580 Fannin St., Houston, TX 77030 ~2.80 miles west of 77221
  • Expensive Downtown hotel
  • 26 floors in property
More Photos Image of Houston Marriott Medical Center/Museum District
From$75
Very Good 4.5 /5 Latest Reviews Call BookMore Details
The Westin Hou Medical Center
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
1709 Dryden Rd., Houston, TX 77030 ~2.81 miles west of 77221
  • 3-star hotel
  • Gym / Fitness Center Available
More Photos Image of The Westin Hou Medical Center
From$90
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Sonder at Mid Main in Houston
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
3550 Main St., Houston, TX 77002 ~2.86 miles northwest of 77221
  • Three Star Downtown property
  • Hotel has 4 floors
More Photos Image of Sonder at Mid Main
From$75
Average 3.0 /5 Reviews Call BookMore Details
Hampton Inn & Suites Houston Medical Center Nrg Park : 1715 Old Spanish Trail
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
1715 Old Spanish Trail, Houston, TX 77054 ~2.91 miles west of 77221
  • 3-star Convention Center hotel
  • Complimentary breakfast is offered
More Photos Exterior of Hampton Inn & Suites Houston Medical Center Nrg Park
From$69
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Houston Medical Center Hotel
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
6700 Main St., Houston, TX 77030 ~2.94 miles west of 77221
  • Midscale Downtown property
  • Check in: 03:00
More Photos Exterior of Houston Medical Center Hotel
From$115
Average 3.5 /5 Recent Reviews Call BookMore Details
InterContinental Houston by IHG : 6750 Main St.
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
6750 Main St., Houston, TX 77030 ~2.98 miles west of 77221
  • Four-star Downtown hotel
  • Hotel has 21 floors
More Photos Image of InterContinental Houston by IHG
From$75
Average 3.0 /5 Hotel Reviews Call BookMore Details
Doubletree by Hilton Houston Medical Center Hotel & Suites : 6800 Main St.
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
6800 Main St., Houston, TX 77030 ~3.01 miles west of 77221
  • Expensive Downtown hotel
  • Hotel has 12 floors
More Photos Photo of Doubletree by Hilton Houston Medical Center Hotel & Suites
From$125
Average 3.0 /5 Guest Reviews Call BookMore Details
Extended Stay America - Houston - Med Ctr-NRG Park-Fannin : 7979 Fannin
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
7979 Fannin, Houston, TX 77054 ~3.01 miles west of 77221
  • Low Cost Convention Center hotel
  • 12 suites in hotel
More Photos Exterior of Extended Stay America - Houston - Med Ctr-NRG Park-Fannin
From$49
Poor 2.5 /5 Recent Reviews Call BookMore Details
Holiday Inn Express Houston Downtown
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
1810 Bell St., Houston, TX 77003 ~3.10 miles north of 77221
  • Mid-scale Downtown hotel
  • Hotel has an eco-friendly policy Read more
More Photos hotel room
From$80
Average 3.0 /5 Review Score Call BookMore Details
Wanderstay Boutique Hotel - Houston
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
520 Sampson St., Houston, TX 77003 ~3.15 miles north of 77221
  • High-end property
  • Hotel has 10 rooms
More Photos Photo of Wanderstay Boutique Hotel
From$125
Average 3.0 /5 Review Score Call BookMore Details
SpringHill Suites Houston Medical Center/NRG Park
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
1400 Old Spanish Trl, Houston, TX 77054 ~3.32 miles west of 77221
  • 3 star Downtown property
  • 190 suites in property
More Photos Image of SpringHill Suites Houston Medical Center/NRG Park
From$80
Average 3.0 /5 Recent Reviews Call BookMore Details
Whyhotel Houston Downtown
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
1515 Austin St., Houston, TX 77002 ~3.33 miles north of 77221
  • 3-star property
  • Hotel has 103 rooms
More Photos hotel room
From$90
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Athens Hotel Suites in Houston
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
1308 Clay St., Houston, TX 77002 ~3.39 miles north of 77221
  • 3 star Downtown property
  • 21 sleeping rooms in hotel
More Photos Exterior of Athens Hotel Suites
From$89
Average 3.0 /5 Hotel Reviews Call BookMore Details
La Colombe D Or Hotel - Houston
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
3410 Montrose Blvd., Houston, TX 77006 ~3.40 miles northwest of 77221
  • 3 star property
  • Hotel has 15 rooms
More Photos hotel room
From$90
Average 3.0 /5 Read Reviews Call BookMore Details
Hilton Americas Houston : 1600 Lamar St.
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
1600 Lamar St., Houston, TX 77010 ~3.40 miles north of 77221
  • Four star Downtown hotel
  • Access to gym on-site
More Photos Photo of Hilton Americas Houston
From$101
Very Good 4.5 /5 Reviews Call BookMore Details
Hotel Saint Augustine
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
4110 Loretto Dr., Houston, TX 77006 ~3.41 miles northwest of 77221
  • Expensive Downtown hotel
  • Check-in: 3:00 PM
More Photos Exterior of Hotel Saint Augustine
From$401
Average 3.0 /5 Latest Reviews Call BookMore Details
Embassy Suites Houston Downtown - Houston
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
1515 Dallas, Houston, TX 77010 ~3.42 miles north of 77221
  • Midscale Downtown property
  • Hotel has 262 rooms
More Photos Exterior of Embassy Suites Houston Downtown
From$135
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Sonder Midtown - Houston
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
306 Mcgowen St., Houston, TX 77006 ~3.44 miles northwest of 77221
  • 3-star Downtown property
  • Check-in time: 4:00 PM
More Photos Photo of Sonder Midtown
From$75
Average 3.0 /5 Review Score Call BookMore Details
Holiday Inn Houston Downtown by IHG in Houston
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
1616 Main St., Houston, TX 77002 ~3.46 miles north of 77221
  • Midscale Downtown property
  • 16 floors in property
More Photos Photo of Holiday Inn Houston Downtown by IHG
From$79
Poor 2.0 /5 Hotel Reviews Call BookMore Details
Marriott Marquis Houston
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
1777 Walker St., Houston, TX 77010 ~3.46 miles north of 77221
  • Expensive hotel
  • Gym is available on property
More Photos Photo of Marriott Marquis Houston
From$375
Very Good 4.0 /5 Reviews Call BookMore Details
Courtyard by Marriott Houston Medical Center/NRG Park
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
Houston Medical Center 7702 Main St., Houston, TX 77030 ~3.47 miles west of 77221
  • Mid-scale Suburban property
  • Hotel has an eco-friendly policy See policy
More Photos Photo of Courtyard by Marriott Houston Medical Center/NRG Park
From$69
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Sonder Lofts at Ballpark - Houston
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
610 St. Emanuel St. Houston Tx 77003, Houston, TX 77003 ~3.47 miles north of 77221
  • Three Star Downtown property
  • 22 rooms in hotel
More Photos Photo of Sonder Lofts at Ballpark
From$100
Average 3.0 /5 Guest Reviews Call BookMore Details
The Reside
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
7755 South Main St., Houston, TX 77054 ~3.50 miles west of 77221
  • Midscale Downtown hotel
  • Hotel has 36 suites
More Photos Photo of The Reside
From$55
Very Good 4.0 /5 Read Reviews Call BookMore Details
Holiday Inn Houston S - Nrg Area - Medical Center by IHG in Houston
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
8111 Kirby Dr., Houston, TX 77054 ~3.50 miles west of 77221
  • Three Star Suburban property
  • 238 sleeping rooms in hotel
More Photos Exterior of Holiday Inn Houston S - Nrg Area - Medical Center by IHG
From$126
Average 3.5 /5 Review Score Call BookMore Details
Four Seasons Hotel Houston
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
1300 Lamar St., Houston, TX 77010 ~3.51 miles north of 77221
  • Luxury 5-star Downtown property
  • Check in time: 3:00 p.m.
More Photos Photo of Four Seasons Hotel Houston
From$275
Very Good 4.0 /5 Read Reviews Call BookMore Details
Extended Stay America Suites Houston Med Ctr NRG Park Kirby
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
1303 La Concha Ln, Houston, TX 77054 ~3.52 miles west of 77221
  • 2-star Convention Center hotel
  • Check in: 3pm
More Photos Photo of Extended Stay America Suites Houston Med Ctr NRG Park Kirby
From$41
Average 3.0 /5 Recent Reviews Call BookMore Details
Courtyard Houston Medical Center / Nrg Park
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
7702 Main St., Houston, TX 77030 ~3.55 miles west of 77221
  • Affordable Downtown hotel
  • Has environment-friendly policy Read more
More Photos Exterior of Courtyard Houston Medical Center / Nrg Park
From$80
Average 3.0 /5 Guest Reviews Call BookMore Details
Bayou City Event Center - Houston
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
9401 Knight Rd., Houston, TX 77045 ~3.55 miles southwest of 77221
  • Cheap hotel
More Photos hotel room
From$60
Average 3.0 /5 Latest Reviews Call BookMore Details
Residence Inn Houston Medical Center / Nrg Park in Houston
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
7807 Kirby Dr., Houston, TX 77030 ~3.56 miles west of 77221
  • Mid-scale Downtown hotel
  • Hotel has 16 floors
More Photos Image of Residence Inn Houston Medical Center / Nrg Park
From$109
Very Good 4.0 /5 Reviews Call BookMore Details

Next: Show All Available 77221 Hotels with Pricing

Graph: Upcoming 20 Days of Houston Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Houston, TX discounts available. The chart reflects the cheapest Houston hotel for each day and each star rating category.

FAQs about hotels near 77221

What are the most favored hotels near 77221?

Home2 Suites, Hotel Zaza Houston Museum District and Houston Marriott Medical Center are the best rated hotels based on customer reviews in the last 365 days.

What are the most luxurious hotels near 77221?

Four Seasons Hotel Houston, Cliù Luxury Boutique Condo Hotel and Hilton University of Houston are the top 3 luxury hotels near 77221.

What hotels are closest to the area of 77221?

Cliù Luxury Boutique Condo Hotel, Extended Stay America Suites Houston Med Ctr Greenway Plaza, and Summit Inn - Houston Medical Center are the properties closest to 77221.

How much does a cheap hotel near 77221 cost per night?

In the last year, a 2 star hotel near 77221 can be as cheap as $63.37 per night. (based on HotelPlanner prices)

How much does a 3 star hotel near 77221 cost per night?

In the last year, the average 3 star hotel near 77221 has been $85.49 per night. (based on HotelPlanner prices)

How much does a 4-5 star hotel near 77221 cost?

In the last year, the average 4 star hotel near 77221 has been $111.54 per night. (based on HotelPlanner prices)

What are the best independent hotels near 77221?

Hotel Zaza Houston Museum District, Scott Inn Suites Downtown Houston and Blossom Houston Medical Center are the best rated independent hotels (not part of a big brand).

What are the most popular Marriott hotels near 77221?

Houston Marriott Medical Center, The Westin Hou Medical Center and Marriott Marquis Houston are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the best IHG hotels near 77221?

Holiday Inn Houston S - Nrg Area - Medical Center by IHG, Holiday Inn Houston Downtown by IHG and InterContinental Houston by IHG are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

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