Hotels in 77221 - Houston TX

Only hotels in 77221 zip code are listed below. Search for cheap and discount hotel rates in Houston, TX for your upcoming leisure or conference / group travel. We list the best 77221 hotels and motels so you can review the Houston hotel list below to find the perfect lodging. Hotels in Harris county and area code 713 are also listed.

Star Rating
Hotel Name
Price Range (USD)to
Amenities

77221 Hotels, Motels & Accommodations

Extended Stay America Houston Greenway Plaza in Houston
+1-888-690-5247

How should we direct your call?

New Reservations: +1-888-690-5247 Group Sales: +1-888-494-8863 Front Desk: 7135210060
2330 SW Frwy, Houston, TX 77098 ~1.17 miles west of 77221
  • 2-star Downtown hotel
  • 3 floors in hotel
  • About half of guests said rooms were clean enough
  • Friendly front desk staff
More PhotosPhoto of Extended Stay America Houston Greenway Plaza
From$61
Average 3.5 /5Recent Reviews CallBookMore Details
Hilton University of Houston
+1-888-305-3366

How should we direct your call?

New Reservations: +1-888-305-3366 Group Sales: +1-888-494-8863 Front Desk: 18325316300
4800 Calhoun Rd., Houston, TX 77004 ~1.39 miles northeast of 77221
  • 4 star Downtown property
  • 86 rooms in hotel
  • Great staff
  • Value for money could be better
More Photos Photo of Hilton University of Houston
From$91
Very Good 4.0 /5Review Score CallBookMore Details
Mainstay Suites
+1-800-881-1523

How should we direct your call?

New Reservations: +1-800-881-1523 Group Sales: +1-888-494-8863 Front Desk: 18322013131
3134 Old Spanish Trail, Houston, TX 77054 ~1.49 miles west of 77221
  • Cheap Convention Center property
  • Fitness + Health Center
  • Clean rooms
  • Great value for the price
More Photos Photo of Mainstay Suites
From$54
Very Good 4.0 /5Reviews CallBookMore Details
Americas Best Value Inn Medical Center Downtown
+1-888-283-3404

How should we direct your call?

New Reservations: +1-888-283-3404 Group Sales: +1-888-494-8863 Front Desk: 12819744432
2419 Riverside Dr., Houston, TX 77004 ~1.65 miles northwest of 77221
  • 2 star property
More Photos hotel room
From$60
Average 3.0 /5Review Score CallBookMore Details
Extended Stay Deluxe Houston Medical Center in Houston
+1-866-221-8581

How should we direct your call?

New Reservations: +1-866-221-8581 Group Sales: +1-888-494-8863
1301 Braeswood Blvd., Houston, TX 77030 ~2.52 miles west of 77221
  • 3 star Convention Center property
  • 4 suites in hotel
  • Most guests had problems with the shower
  • Bathrooms and rooms are untidy
More Photos hotel room
From$64
Average 3.0 /5Read Reviews CallBookMore Details
Hotel Zaza Houston
+1-866-429-5787

How should we direct your call?

New Reservations: +1-866-429-5787 Group Sales: +1-888-494-8863 Front Desk: 17135261991
5701 Main St., Houston, TX 77005 ~2.57 miles northwest of 77221
  • High-end Downtown hotel
  • Check-in: 4:00 PM
  • Most guests thought, the hotel was modern
  • For 70%, parking prices were too high
More Photos Exterior of Hotel Zaza Houston
From$179
Very Good 4.5 /5Read Reviews CallBookMore Details
Lexington Hotel Houston Medical Center - Houston
+1-888-690-5281

How should we direct your call?

New Reservations: +1-888-690-5281 Group Sales: +1-888-494-8863 Front Desk: 17137901617
1025 Swanson St., Houston, TX 77030 ~2.78 miles west of 77221
  • Low priced Downtown property
  • Free complimentary breakfast
  • Nice pool outside
  • Hospital all day
More Photos Exterior of Lexington Hotel Houston Medical Center
From$60
Average 3.5 /5Guest Reviews CallBookMore Details
Houston Marriott Medical Center
+1-888-690-5247

How should we direct your call?

New Reservations: +1-888-690-5247 Group Sales: +1-888-494-8863 Front Desk: 469.443.9502
6580 Fannin St., Houston, TX 77030 ~2.80 miles west of 77221
  • Expensive Downtown hotel
  • 14 conference rooms in property
More Photos Image of Houston Marriott Medical Center
From$89
Very Good 4.0 /5Review Score CallBookMore Details
Hampton Inn & Suites Medical Center
+1-888-305-3366

How should we direct your call?

New Reservations: +1-888-305-3366 Group Sales: +1-888-494-8863 Front Desk: 17137970040
1715 Old Spanish Trail, Houston, TX 77054 ~2.92 miles west of 77221
  • 3 star Convention Center property
  • 37 suites in property
More Photos Exterior of Hampton Inn & Suites Medical Center
From$75
Very Good 4.0 /5Hotel Reviews CallBookMore Details
Best Western Plaza Hotel & Suites at Medical Center : 6700 South Main St.
+1-800-881-1523

How should we direct your call?

New Reservations: +1-800-881-1523 Group Sales: +1-888-494-8863 Front Desk: 713/5222811
6700 South Main St., Houston, TX 77030 ~2.94 miles west of 77221
  • Mid-scale Downtown property
  • 125 sleeping rooms in hotel
More Photos Image of Best Western Plaza Hotel & Suites at Medical Center
From$115
Average 3.5 /5Review Score CallBookMore Details
Hilton Houston Plaza / Medical Center : 6633 Travis St.
+1-888-283-3404

How should we direct your call?

New Reservations: +1-888-283-3404 Group Sales: +1-888-494-8863 Front Desk: 17133134000
6633 Travis St., Houston, TX 77030 ~2.94 miles west of 77221
  • 4-star Downtown hotel
  • 186 rooms in hotel
  • Average beds
  • All guests were happy with the room service
More Photos Exterior of Hilton Houston Plaza / Medical Center
From$75
Average 3.5 /5Recent Reviews CallBookMore Details
Robin's Nest Bed & Breakfast Inn
+1-866-221-8581

How should we direct your call?

New Reservations: +1-866-221-8581 Group Sales: +1-888-494-8863
4104 Greeley St., Houston, TX 77006 ~2.99 miles northwest of 77221
  • 3 star Downtown property
  • Shuttle to airport available
More Photos Exterior of Robin's Nest Bed & Breakfast Inn
From$195
Very Good 4.5 /5Review Score CallBookMore Details
Wyndham Houston Medical Center Hotel & Suite
+1-866-429-5787

How should we direct your call?

New Reservations: +1-866-429-5787 Group Sales: +1-888-494-8863 Front Desk: 17135287744
6800 Main St., Houston, TX 77030 ~2.99 miles west of 77221
  • Affordable Downtown hotel
  • 287 sleeping rooms in hotel
  • The majority of guests thought the atmosphere was somewhat friendly
  • Rooms are ok
More Photos Image of Wyndham Houston Medical Center Hotel & Suite
From$89
Very Good 4.0 /5Review Score CallBookMore Details
Extended Houston Med. Center Ngr Pk. Fannin S (Med - Houston
+1-888-690-5281

How should we direct your call?

New Reservations: +1-888-690-5281 Group Sales: +1-888-494-8863 Front Desk: 7137970000
7979 Fannin, Houston, TX 77054 ~3.02 miles west of 77221
  • Cheap Convention Center property
  • Check-in: 3pm
  • Service is below average
  • Almost all guests didn't like the uncomfortable beds
More Photos Exterior of Extended Houston Med. Center Ngr Pk. Fannin S (Med
From$49
Poor 2.5 /5Reviews CallBookMore Details
Holiday Inn Express & Suites Downtown
+1-888-690-5247

How should we direct your call?

New Reservations: +1-888-690-5247 Group Sales: +1-888-494-8863 Front Desk: 17136529400
1810 Bell St., Houston, TX 77003 ~3.14 miles north of 77221
  • Midscale Downtown property
  • 4 floors in hotel
More Photos Exterior of Holiday Inn Express & Suites Downtown
From$79
Very Good 4.0 /5Recent Reviews CallBookMore Details
Springhill Suites by Marriott Houston Nrg Park in Houston
+1-888-305-3366

How should we direct your call?

New Reservations: +1-888-305-3366 Group Sales: +1-888-494-8863 Front Desk: 17137961000
1400 Old Spanish Trail, Houston, TX 77054 ~3.33 miles west of 77221
  • Three Star Downtown property
  • Fitness + Health Center
  • Affordable parking
  • About half of guests didn't like the unstylish hotel
More Photos Exterior of Springhill Suites by Marriott Houston Nrg Park
From$81
Very Good 4.0 /5Review Score CallBookMore Details
Athens Hotel in Houston
+1-800-881-1523

How should we direct your call?

New Reservations: +1-800-881-1523 Group Sales: +1-888-494-8863 Front Desk: 17137191960
1308 Clay St., Houston, TX 77002 ~3.41 miles north of 77221
  • Two star Downtown hotel
  • Fitness + Health Center
  • About half of guests said the wifi quality was bad
  • Good minibar
More Photos Photo of Athens Hotel
From$49
Average 3.5 /5Reviews CallBookMore Details
Embassy Suites Houston Downtown - Houston
+1-888-283-3404

How should we direct your call?

New Reservations: +1-888-283-3404 Group Sales: +1-888-494-8863 Front Desk: 17137399100
1515 Dallas, Houston, TX 77010 ~3.43 miles north of 77221
  • 3-star Downtown hotel
  • Free breakfast available
More Photos Exterior of Embassy Suites Houston Downtown
From$135
Very Good 4.5 /5Reviews CallBookMore Details
Holiday Inn Houston Downtown
+1-866-221-8581

How should we direct your call?

New Reservations: +1-866-221-8581 Group Sales: +1-888-494-8863 Front Desk: 17136588888
1616 Main St., Houston, TX 77002 ~3.44 miles north of 77221
  • Affordable Downtown hotel
  • Check in: 3:00 PM
More Photos Photo of Holiday Inn Houston Downtown
From$79
Very Good 4.0 /5Hotel Reviews CallBookMore Details
Holiday Inn Houston N R G Park Area in Houston
+1-866-429-5787

How should we direct your call?

New Reservations: +1-866-429-5787 Group Sales: +1-888-494-8863 Front Desk: 17137901900
8111 Kirby Dr., Houston, TX 77054 ~3.51 miles west of 77221
  • Three Star Suburban property
  • Check-in time: 4:00 PM
  • Room service could have been improved
  • Manager comped
More Photos Exterior of Holiday Inn Houston N R G Park Area
From$79
Average 3.5 /5Latest Reviews CallBookMore Details
Extended Stay Deluxe Houston Medical Center La Con in Houston
+1-888-690-5281

How should we direct your call?

New Reservations: +1-888-690-5281 Group Sales: +1-888-494-8863 Front Desk: 17139609660
1303 La Concha Ln, Houston, TX 77054 ~3.52 miles west of 77221
  • Economy Convention Center property
  • Check-in time: 3pm
  • Friendly service
  • Rooms weren't completely clean
More Photos Exterior of Extended Stay Deluxe Houston Medical Center La Con
From$41
Very Good 4.5 /5Guest Reviews CallBookMore Details
Four Seasons Hotel Houston
+1-888-690-5247

How should we direct your call?

New Reservations: +1-888-690-5247 Group Sales: +1-888-494-8863 Front Desk: 17136501300
1300 Lamar St., Houston, TX 77010 ~3.52 miles north of 77221
  • Luxury 5 star Downtown property
  • Check in time: 3:00 p.m.
  • The majority of guests were happy with the room service
  • Popular among business travelers
More Photos Image of Four Seasons Hotel Houston
From$120
Very Good 4.5 /5Hotel Reviews CallBookMore Details
Moody Manor at the Houston Medical Center - Houston
+1-888-305-3366

How should we direct your call?

New Reservations: +1-888-305-3366 Group Sales: +1-888-494-8863 Front Desk: 17133511400
7706 South Main St., Houston, TX 77030 ~3.53 miles west of 77221
  • Cheap Downtown hotel
  • 54 rooms in property
  • Very good hotel
  • Good service
More Photos Photo of Moody Manor at the Houston Medical Center
From$79
Average 3.0 /5Reviews CallBookMore Details
Residence Inn by Marriott Medical Center / Reliant
+1-800-881-1523

How should we direct your call?

New Reservations: +1-800-881-1523 Group Sales: +1-888-494-8863 Front Desk: 17136607993
7710 Main St., Houston, TX 77030 ~3.54 miles west of 77221
  • Midscale Highway property
  • Fitness center on property
  • Staff were pleasant and helpful
  • Great location
More Photos Image of Residence Inn by Marriott Medical Center / Reliant
From$69
Average 3.5 /5Recent Reviews CallBookMore Details
Courtyard by Marriott Houston Medical Center : Houston Medical Center 7702 Main St.
+1-888-283-3404

How should we direct your call?

New Reservations: +1-888-283-3404 Group Sales: +1-888-494-8863 Front Desk: 17136684500
Houston Medical Center 7702 Main St., Houston, TX 77030 ~3.56 miles west of 77221
  • Three Star Suburban property
  • Access to gym on-site
  • Nice patio furniture
  • Affordable parking
More Photos Image of Courtyard by Marriott Houston Medical Center
From$159
Very Good 4.0 /5Review Score CallBookMore Details
Moody Manor - Houston
+1-866-221-8581

How should we direct your call?

New Reservations: +1-866-221-8581 Group Sales: +1-888-494-8863 Front Desk: 17136607993
7706 Main St., Houston, TX 77030 ~3.58 miles west of 77221
  • 3 star Downtown hotel
  • 2 floors in property
More Photos Exterior of Moody Manor
From$49
Average 3.0 /5Recent Reviews CallBookMore Details
Hampton Inn Houston Downtown in Houston
+1-866-429-5787

How should we direct your call?

New Reservations: +1-866-429-5787 Group Sales: +1-888-494-8863 Front Desk: 17132240011
710 Crawford St., Houston, TX 77002 ~3.58 miles north of 77221
  • Mid-scale Convention Center hotel
  • 2 conference rooms in property
More Photos Image of Hampton Inn Houston Downtown
From$95
Very Good 4.5 /5Latest Reviews CallBookMore Details
The Whitehall Houston : 1700 Smith St.
+1-888-690-5281

How should we direct your call?

New Reservations: +1-888-690-5281 Group Sales: +1-888-494-8863 Front Desk: 17137398800
1700 Smith St., Houston, TX 77002 ~3.62 miles north of 77221
  • Expensive Downtown property
  • Check in time: 12 Noon
  • Desserts were ok, said 50%
  • Great location
More Photos Photo of The Whitehall Houston
From$89
Very Good 4.5 /5Read Reviews CallBookMore Details
Rodeway Inn Suites
+1-888-690-5247

How should we direct your call?

New Reservations: +1-888-690-5247 Group Sales: +1-888-494-8863
6712 Morningside Dr., Houston, TX 77030 ~3.63 miles west of 77221
  • Two-star Downtown property
  • 33 rooms in property
  • Room needs to be redecorated
  • Older property
More Photos Photo of Rodeway Inn Suites
From$60
Not Good 1.5 /5Review Score CallBookMore Details
Americas Best Value Inn Near Nrg Park / Medical Center
+1-888-305-3366

How should we direct your call?

New Reservations: +1-888-305-3366 Group Sales: +1-888-494-8863 Front Desk: 17136678200
7905 South Main St., Houston, TX 77025 ~3.63 miles west of 77221
  • Economy property
  • 2 floors in property
More Photos hotel room
From$72
Average 3.0 /5Latest Reviews CallBookMore Details
Courtyard Houston Downtown
+1-800-881-1523

How should we direct your call?

New Reservations: +1-800-881-1523 Group Sales: +1-888-494-8863 Front Desk: 8323661600
916 Dallas St., Houston, TX 77002 ~3.64 miles north of 77221
  • 3 star Downtown hotel
  • 5 meeting rooms in hotel
More Photos Photo of Courtyard Houston Downtown
From$89
Average 3.5 /5Hotel Reviews CallBookMore Details
Residence Inn Houston Downtown - Houston
+1-888-283-3404

How should we direct your call?

New Reservations: +1-888-283-3404 Group Sales: +1-888-494-8863 Front Desk: 18323661000
904 Dallas St., Houston, TX 77002 ~3.64 miles north of 77221
  • 3-star Downtown hotel
  • Gym / Fitness Center Available
More Photos Image of Residence Inn Houston Downtown
From$79
Very Good 4.0 /5Recent Reviews CallBookMore Details
Springhill Suites Houston Downtown / Convention Ce - Houston
+1-866-221-8581

How should we direct your call?

New Reservations: +1-866-221-8581 Group Sales: +1-888-494-8863 Front Desk: 17136550002
914 Dallas St., Houston, TX 77002 ~3.65 miles north of 77221
  • 3 star hotel
More Photos Image of Springhill Suites Houston Downtown / Convention Ce
From$80
Very Good 4.0 /5Reviews CallBookMore Details
The Westin Houston Downtown in Houston
+1-866-429-5787

How should we direct your call?

New Reservations: +1-866-429-5787 Group Sales: +1-888-494-8863 Front Desk: 17132281520
1520 Texas Ave., Houston, TX 77002 ~3.71 miles north of 77221
  • High-end Downtown hotel
  • 200 rooms in hotel
  • Good bar and breakfast
  • Great view
More Photos Image of The Westin Houston Downtown
From$99
Very Good 4.5 /5Recent Reviews CallBookMore Details
Hotel Ylem
+1-888-690-5281

How should we direct your call?

New Reservations: +1-888-690-5281 Group Sales: +1-888-494-8863 Front Desk: 17136654439
8080 South Main St., Houston, TX 77025 ~3.72 miles west of 77221
  • Midscale Downtown hotel
  • Free comp. breakfast
  • Almost all guests said the beds were comfortable
  • Most guests said the beds were comfortable
More Photos Image of Hotel Ylem
From$69
Very Good 4.0 /5Reviews CallBookMore Details
Aloft Houston Downtown : 820 Fannin St.
+1-888-690-5247

How should we direct your call?

New Reservations: +1-888-690-5247 Group Sales: +1-888-494-8863 Front Desk: 17132250200
820 Fannin St., Houston, TX 77002 ~3.76 miles north of 77221
  • 3 star Downtown hotel
  • 10 floors in hotel
More Photos Image of Aloft Houston Downtown
From$92
Average 3.5 /5Read Reviews CallBookMore Details
Hyatt Regency Houston - Houston
+1-888-305-3366

How should we direct your call?

New Reservations: +1-888-305-3366 Group Sales: +1-888-494-8863 Front Desk: 17136541234
1200 Louisiana St., Houston, TX 77002 ~3.76 miles north of 77221
  • Four star Downtown hotel
  • Gym / Fitness Center Available
More Photos Photo of Hyatt Regency Houston
From$179
Very Good 4.0 /5Guest Reviews CallBookMore Details
Club Quarters Hotel Houston
+1-800-881-1523

How should we direct your call?

New Reservations: +1-800-881-1523 Group Sales: +1-888-494-8863 Front Desk: 12039052071
720 Fannin St., Houston, TX 77002 ~3.80 miles north of 77221
  • Four star hotel
  • 100 sleeping rooms in hotel
More Photos Photo of Club Quarters Hotel Houston
From$125
Very Good 4.0 /5Latest Reviews CallBookMore Details
JW Marriott Houston Downtown in Houston
+1-888-283-3404

How should we direct your call?

New Reservations: +1-888-283-3404 Group Sales: +1-888-494-8863 Front Desk: 17132371111
806 Main, Houston, TX 77002 ~3.82 miles north of 77221
  • Luxurious 5 Star Downtown hotel
  • Check in: 3:00 PM
More Photos Image of JW Marriott Houston Downtown
From$139
Very Good 4.5 /5Reviews CallBookMore Details
Magnolia Hotel in Houston
+1-866-221-8581

How should we direct your call?

New Reservations: +1-866-221-8581 Group Sales: +1-888-494-8863 Front Desk: 17132210011
1100 Texas Ave., Houston, TX 77002 ~3.84 miles north of 77221
  • 4-star Downtown hotel
  • 314 rooms in hotel
  • Delicious food
  • Great desserts & fruits
More Photos Photo of Magnolia Hotel
From$94
Very Good 4.5 /5Guest Reviews CallBookMore Details
Comfort Suites : 1055 Mcnee Rd.
+1-866-429-5787

How should we direct your call?

New Reservations: +1-866-429-5787 Group Sales: +1-888-494-8863 Front Desk: 7136681436
1055 Mcnee Rd., Houston, TX 77054 ~3.85 miles west of 77221
  • 3 star Convention Center property
  • Complimentary breakfast is offered
More Photos Photo of Comfort Suites
From$65
CallBookMore Details
Crowne Plaza Houston Near Reliant Medical
+1-888-690-5281

How should we direct your call?

New Reservations: +1-888-690-5281 Group Sales: +1-888-494-8863
8686 Kirby Dr., Houston, TX 77054 ~3.86 miles west of 77221
  • Three Star Convention Center property
  • Check in: 12pm
More Photos Photo of Crowne Plaza Houston Near Reliant Medical
From$99
Average 3.0 /5Reviews CallBookMore Details
Doubletree by Hilton Houston Downtown - Houston
+1-888-690-5247

How should we direct your call?

New Reservations: +1-888-690-5247 Group Sales: +1-888-494-8863 Front Desk: 17137590202
400 Dallas St., Houston, TX 77002 ~3.86 miles north of 77221
  • Three Star Downtown property
  • 350 rooms in property
  • The majority of guests enjoyed the friendly atmosphere
  • Good bar
More Photos Photo of Doubletree by Hilton Houston Downtown
From$80
Very Good 4.0 /5Read Reviews CallBookMore Details
The Sam Houston Hotel Curio a Collection by Hilton : 1117 Prairie St.
+1-888-305-3366

How should we direct your call?

New Reservations: +1-888-305-3366 Group Sales: +1-888-494-8863 Front Desk: 18322008800
1117 Prairie St., Houston, TX 77002 ~3.91 miles north of 77221
  • 4-star Downtown property
  • 3 meeting rooms in hotel
More Photos Image of The Sam Houston Hotel Curio a Collection by Hilton
From$99
Very Good 4.0 /5Latest Reviews CallBookMore Details
Best Western Plus Downtown Inn & Suites
+1-800-881-1523

How should we direct your call?

New Reservations: +1-800-881-1523 Group Sales: +1-888-494-8863 Front Desk: 17135717733
915 West Dallas St., Houston, TX 77019 ~3.96 miles north of 77221
  • Affordable Downtown property
  • 4 floors in property
  • Affordable beverage prices
  • Most guests found problems with the furniture
More Photos Exterior of Best Western Plus Downtown Inn & Suites
From$115
Very Good 4.5 /5Guest Reviews CallBookMore Details
The Quality Inn & Suites Reliant Park - Houston
+1-888-283-3404

How should we direct your call?

New Reservations: +1-888-283-3404 Group Sales: +1-888-494-8863 Front Desk: 17137992436
2364 South Loop West, Houston, TX 77054 ~3.99 miles west of 77221
  • 3-star Convention Center hotel
  • 106 rooms in property
  • Most guests thought they were poorly maintained
  • Most guests said rooms were big enough
More Photos Image of The Quality Inn & Suites Reliant Park
From$72
Average 3.0 /5Read Reviews CallBookMore Details
Staybridge Suites Houston Medical Center in Houston
+1-866-221-8581

How should we direct your call?

New Reservations: +1-866-221-8581 Group Sales: +1-888-494-8863 Front Desk: 3463196461
9000 South Main St., Houston, TX 77025 ~4.02 miles west of 77221
  • Three Star Downtown hotel
  • Hotel has an eco-friendly policy See policy
More Photos Photo of Staybridge Suites Houston Medical Center
From$109
Very Good 4.0 /5Guest Reviews CallBookMore Details
The Lancaster Hotel in Houston
+1-866-429-5787

How should we direct your call?

New Reservations: +1-866-429-5787 Group Sales: +1-888-494-8863 Front Desk: 17132289500
701 Texas Ave., Houston, TX 77002 ~4.03 miles north of 77221
  • Four star Downtown property
  • Gym is available on property
More Photos Exterior of The Lancaster Hotel
From$125
Very Good 4.5 /5Latest Reviews CallBookMore Details
Hotel Icon Houston
+1-888-690-5281

How should we direct your call?

New Reservations: +1-888-690-5281 Group Sales: +1-888-494-8863 Front Desk: 17132244266
220 Main St., Houston, TX 77002 ~4.08 miles north of 77221
  • High end Downtown hotel
  • 6 meeting rooms in hotel
More Photos Photo of Hotel Icon Houston
From$109
Very Good 4.5 /5Reviews CallBookMore Details
Holiday Inn Express & Suites Houston S Medical Center Area - Houston
+1-888-690-5247

How should we direct your call?

New Reservations: +1-888-690-5247 Group Sales: +1-888-494-8863 Front Desk: +18323719300
9300 South Main St., Houston, TX 77025 ~4.31 miles west of 77221
  • Two star Downtown hotel
  • 30 suites in hotel
More Photos Image of Holiday Inn Express & Suites Houston S Medical Center Area
From$89
Excellent 5.0 /5Review Score CallBookMore Details

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