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77221 Hotels/Accommodations

Cliù Luxury Boutique Condo Hotel in Houston
+1-888-389-4121
3144 Southmore Blvd. Unit 10, Houston, TX 77004 ~1.13 miles northwest of 77221
  • 4-star Downtown property
  • Check in time: 4:00pm CST
From$100
Average 3.0 /5 Hotel Reviews Call BookMore Details
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Extended Stay America Suites Houston Med Ctr Greenway Plaza
+1-888-675-2083
2330 Southwest Frwy, Houston, TX 77098 ~1.17 miles west of 77221
  • Cheap Downtown property
  • Free comp. breakfast
From$61
Average 3.0 /5 Recent Reviews Call BookMore Details
Summit Inn - Houston Medical Center
+1-800-716-8490
3138 Old Spanish Trail, Houston, TX 77054 ~1.37 miles west of 77221
  • Cheap property
  • Check in: 11:00
From$60
Average 3.0 /5 Read Reviews Call BookMore Details
MainStay Suites Texas Medical Center/Reliant Park in Houston
+1-800-805-5223
3134 Old Spanish Trail, Houston, TX 77054 ~1.41 miles west of 77221
  • Cheap Convention Center hotel
  • Check-in: 11:00
From$60
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Hilton University of Houston : 4800 Calhoun Rd.
+1-888-965-1860
4800 Calhoun Rd., Houston, TX 77004 ~1.54 miles northeast of 77221
  • Four-star Downtown property
  • 8 floors in property
From$125
Average 3.0 /5 Reviews Call BookMore Details
Americas Best Value Inn Medical Center Downtown : 2419 Riverside Dr.
+1-888-788-5576
2419 Riverside Dr., Houston, TX 77004 ~1.65 miles northwest of 77221
  • Two star property
  • Complimentary breakfast is offered
From$60
Very Good 4.0 /5 Reviews Call BookMore Details
Home2 Suites : 6840 Almeda Rd.
+1-888-897-9207
6840 Almeda Rd., Houston, TX 77030 ~1.82 miles west of 77221
  • 3 star Suburban hotel
  • Hotel has 143 rooms
From$99
Excellent 5.0 /5 Reviews Call BookMore Details
Hilton Garden Inn - Houston
+1-888-311-4278
6840b Almeda Rd., Houston, TX 77030 ~1.82 miles west of 77221
  • 3 star Suburban hotel
  • Access to gym on-site
From$109
Average 3.0 /5 Read Reviews Call BookMore Details
Hilton Garden - Houston
+1-888-469-4795
6840 B Almeda Rd., Houston, TX 77030 ~1.82 miles west of 77221
  • 3-star hotel
From$80
Average 3.0 /5 Reviews Call BookMore Details
Medical District
+1-888-734-9421
2700 Old Spanish Trail, Houston, TX 77021 ~1.92 miles west of 77221
  • Four-star property
From$75
Average 3.0 /5 Review Score Call BookMore Details
Sonder The Hampstead - Houston
+1-888-841-5292
1508 Blodgett, Houston, TX 77004 ~2.33 miles northwest of 77221
  • Mid-scale Downtown hotel
  • 36 rooms in hotel
From$80
Average 3.0 /5 Guest Reviews Call BookMore Details
Scott Inn Suites Downtown Houston - Houston
+1-888-455-5160
1933 Scott St., Houston, TX 77003 ~2.34 miles north of 77221
  • 3-star property
  • Check-in time: 15:00
From$90
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Best Way Inn Houston - Medical Center in Houston
+1-888-965-8297
3100 Holmes Rd., Houston, TX 77051 ~2.49 miles southwest of 77221
  • Cheap property
  • 42 sleeping rooms in hotel
From$60
Average 3.0 /5 Read Reviews Call BookMore Details
Extended Stay America Suites Houston Med Ctr Braeswood Bl
+1-888-906-6358
1301 Braeswood Blvd., Houston, TX 77030 ~2.52 miles west of 77221
  • 3 star Convention Center property
  • Fitness / Gym is on-site
From$64
Average 3.0 /5 Latest Reviews Call BookMore Details
Hotel Zaza Houston Museum District : 5701 Main St.
+1-888-749-6785
5701 Main St., Houston, TX 77005 ~2.57 miles northwest of 77221
  • High-end Downtown property
  • 315 rooms in hotel
From$159
Very Good 4.5 /5 Read Reviews Call BookMore Details
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Blossom Houston Medical Center in Houston
+1-888-878-9982
7114 Bertner Ave., Houston, TX 77030 ~2.68 miles west of 77221
  • Midscale hotel
  • Check in: 16:00
From$90
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Blossom Hotel Houston in Houston
+1-888-389-4485
7118 Bertner Ave., Houston, TX 77030 ~2.69 miles west of 77221
  • 4 star Convention Center hotel
  • 16 floors in hotel
From$99
Average 3.0 /5 Latest Reviews Call BookMore Details
Days Inn & Suites by Wyndham Downtown / University of Houston
+1-888-389-4121
6190 Gulf Freeway, Houston, TX 77023 ~2.73 miles east of 77221
  • Mid-scale Downtown hotel
  • 52 rooms in property
From$55
Average 3.0 /5 Read Reviews Call BookMore Details
Lexington Hotel Houston Medical Center in Houston
+1-888-675-2083
1025 Swanson St., Houston, TX 77030 ~2.78 miles west of 77221
  • Low Cost Downtown hotel
  • Fitness center on property
From$60
Average 3.5 /5 Latest Reviews Call BookMore Details
Hyatt Place - Houston
+1-800-716-8490
7329a Fannin St., Houston, TX 77030 ~2.79 miles west of 77221
  • 3 star property
From$80
Average 3.0 /5 Read Reviews Call BookMore Details
Hyatt Place Hyatt House Houston Medical Center in Houston
+1-800-805-5223
7329 Fannin St., Houston, TX 77030 ~2.79 miles west of 77221
  • Midscale Suburban hotel
  • 3 meeting rooms in property
From$99
Average 3.0 /5 Guest Reviews Call BookMore Details
Houston Marriott Medical Center/Museum District
+1-888-965-1860
6580 Fannin St., Houston, TX 77030 ~2.80 miles west of 77221
  • 4-star Downtown hotel
  • Hotel has 22 suites
From$75
Very Good 4.5 /5 Hotel Reviews Call BookMore Details
The Westin Hou Medical Center in Houston
+1-888-788-5576
1709 Dryden Rd., Houston, TX 77030 ~2.81 miles west of 77221
  • Affordable property
  • 273 rooms in property
From$90
Very Good 4.0 /5 Reviews Call BookMore Details
Sonder at Mid Main
+1-888-897-9207
3550 Main St., Houston, TX 77002 ~2.87 miles northwest of 77221
  • Mid-scale Downtown hotel
  • Check in: 4:00 pm
From$75
Average 3.0 /5 Hotel Reviews Call BookMore Details
Hampton Inn & Suites Houston Medical Center Nrg Park - Houston
+1-888-311-4278
1715 Old Spanish Trail, Houston, TX 77054 ~2.92 miles west of 77221
  • Affordable Convention Center property
  • Check-in time: 3:00PM
From$69
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Houston Medical Center Hotel
+1-888-469-4795
6700 Main St., Houston, TX 77030 ~2.94 miles west of 77221
  • 3-star Downtown property
  • Hotel has 6 floors
From$115
Average 3.5 /5 Latest Reviews Call BookMore Details
InterContinental Houston by IHG
+1-888-734-9421
6750 Main St., Houston, TX 77030 ~2.98 miles west of 77221
  • 4 star Downtown property
  • Gym / Fitness Center Available
From$75
Average 3.0 /5 Reviews Call BookMore Details
Doubletree by Hilton Houston Medical Center Hotel & Suites
+1-888-841-5292
6800 Main St., Houston, TX 77030 ~3.01 miles west of 77221
  • Expensive Downtown property
  • Fitness center on property
From$125
Average 3.0 /5 Guest Reviews Call BookMore Details
Extended Stay America - Houston - Med Ctr-NRG Park-Fannin - Houston
+1-888-455-5160
7979 Fannin, Houston, TX 77054 ~3.02 miles west of 77221
  • Low-priced Convention Center property
  • Check-in: 3pm
From$49
Poor 2.5 /5 Reviews Call BookMore Details
Holiday Inn Express Hotel & Suites Houston-Downtown Conv Ctr by I - Houston
+1-888-965-8297
1810 Bell St., Houston, TX 77003 ~3.11 miles north of 77221
  • Affordable Downtown property
  • Gym / Fitness Center Available
From$108
Very Good 4.0 /5 Reviews Call BookMore Details
Wanderstay Boutique Hotel
+1-888-906-6358
520 Sampson St., Houston, TX 77003 ~3.16 miles north of 77221
  • Expensive property
  • Check-in: 2:00PM CST
From$125
Average 3.0 /5 Guest Reviews Call BookMore Details
Springhill Suites Marriott Medical Center Nrg Park
+1-888-749-6785
1400 Old Spanish Trl, Houston, TX 77054 ~3.33 miles west of 77221
  • 3-star Downtown property
  • Hotel has 190 suites
From$80
Average 3.0 /5 Review Score Call BookMore Details
Whyhotel Houston Downtown
+1-888-878-9982
1515 Austin St., Houston, TX 77002 ~3.33 miles north of 77221
  • Affordable hotel
  • Hotel has 103 rooms
From$90
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Athens Hotel Suites
+1-888-389-4485
1308 Clay St., Houston, TX 77002 ~3.39 miles north of 77221
  • 3 star Downtown hotel
  • Check-in time: 3PM
From$89
Average 3.0 /5 Guest Reviews Call BookMore Details
La Colombe D Or Hotel in Houston
+1-888-389-4121
3410 Montrose Blvd., Houston, TX 77006 ~3.41 miles northwest of 77221
  • 3 star property
  • 15 rooms in hotel
From$90
Average 3.0 /5 Read Reviews Call BookMore Details
Hilton Americas Houston
+1-888-675-2083
1600 Lamar St., Houston, TX 77010 ~3.41 miles north of 77221
  • Four-star Downtown property
  • Fitness center on property
From$101
Very Good 4.5 /5 Read Reviews Call BookMore Details
Hotel Saint Augustine in Houston
+1-800-716-8490
4110 Loretto Dr., Houston, TX 77006 ~3.41 miles northwest of 77221
  • High end Downtown hotel
  • 2 floors in property
From$401
Average 3.0 /5 Review Score Call BookMore Details
Embassy Suites Houston Downtown in Houston
+1-800-805-5223
1515 Dallas, Houston, TX 77010 ~3.43 miles north of 77221
  • Mid-scale Downtown property
  • 262 suites in hotel
From$135
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Sonder Midtown : 306 Mcgowen St.
+1-888-965-1860
306 Mcgowen St., Houston, TX 77006 ~3.44 miles northwest of 77221
  • Midscale Downtown hotel
  • Access to gym on-site
From$75
Average 3.0 /5 Hotel Reviews Call BookMore Details
Holiday Inn Houston Downtown by IHG
+1-888-788-5576
1616 Main St., Houston, TX 77002 ~3.46 miles north of 77221
  • Midscale Downtown property
  • 16 floors in hotel
Marriott Marquis Houston
+1-888-897-9207
1777 Walker St., Houston, TX 77010 ~3.47 miles north of 77221
  • High-end property
  • 76 conference rooms in property
From$375
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Courtyard by Marriott Houston Medical Center/NRG Park
+1-888-311-4278
Houston Medical Center 7702 Main St., Houston, TX 77030 ~3.48 miles west of 77221
  • Three Star Suburban property
  • Hotel has 8 floors
From$69
Very Good 4.0 /5 Review Score Call BookMore Details
Sonder Lofts at Ballpark - Houston
+1-888-469-4795
610 St. Emanuel St. Houston Tx 77003, Houston, TX 77003 ~3.48 miles north of 77221
  • Midscale Downtown property
  • Check-in time: 4:00 PM
From$100
Average 3.0 /5 Latest Reviews Call BookMore Details
The Reside : 7755 South Main St.
+1-888-734-9421
7755 South Main St., Houston, TX 77054 ~3.51 miles west of 77221
  • Three Star Downtown property
  • Hotel has 3 floors
From$55
Very Good 4.0 /5 Read Reviews Call BookMore Details
Holiday Inn Houston S - Nrg Area - Medical Center by IHG
+1-888-841-5292
8111 Kirby Dr., Houston, TX 77054 ~3.51 miles west of 77221
  • 3 star Suburban property
  • Check-in: 3:00 PM
From$126
Average 3.5 /5 Review Score Call BookMore Details
Four Seasons Hotel Houston
+1-888-455-5160
1300 Lamar St., Houston, TX 77010 ~3.51 miles north of 77221
  • Luxury 5-star Downtown property
  • 115 suites in hotel
From$275
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Extended Stay America Suites Houston Med Ctr NRG Park Kirby in Houston
+1-888-965-8297
1303 La Concha Ln, Houston, TX 77054 ~3.52 miles west of 77221
  • 2 star Convention Center hotel
  • 45 suites in property
From$41
Average 3.0 /5 Hotel Reviews Call BookMore Details
Courtyard Houston Medical Center / Nrg Park : 7702 Main St.
+1-888-906-6358
7702 Main St., Houston, TX 77030 ~3.55 miles west of 77221
  • 3-star Downtown property
  • 3 conference rooms in property
From$80
Average 3.0 /5 Recent Reviews Call BookMore Details
Bayou City Event Center in Houston
+1-888-749-6785
9401 Knight Rd., Houston, TX 77045 ~3.56 miles southwest of 77221
  • Inexpensive hotel
From$60
Average 3.0 /5 Latest Reviews Call BookMore Details
Residence Inn Houston Medical Center / Nrg Park in Houston
+1-888-878-9982
7807 Kirby Dr., Houston, TX 77030 ~3.56 miles west of 77221
  • Three Star Downtown property
  • Hotel has 16 floors
From$109
Very Good 4.0 /5 Reviews Call BookMore Details

Next: Show All Available 77221 Hotels with Pricing

Graph: Upcoming 20 Days of Houston Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Houston, TX discounts available. The chart reflects the cheapest Houston hotel for each day and each star rating category.

FAQs about hotels near 77221

What are the most favored hotels near 77221?

Home2 Suites, Hotel Zaza Houston Museum District and Houston Marriott Medical Center are the best rated hotels based on customer reviews in the last 365 days.

What are the most luxurious hotels near 77221?

Four Seasons Hotel Houston, Cliù Luxury Boutique Condo Hotel and Hilton University of Houston are the top 3 luxury hotels near 77221.

What hotels are closest to the area of 77221?

Cliù Luxury Boutique Condo Hotel, Extended Stay America Suites Houston Med Ctr Greenway Plaza, and Summit Inn - Houston Medical Center are the properties closest to 77221.

How much does a cheap hotel near 77221 cost per night?

In the last year, a 2 star hotel near 77221 can be as cheap as $63.37 per night. (based on HotelPlanner prices)

How much does a 3 star hotel near 77221 cost per night?

In the last year, the average 3 star hotel near 77221 has been $85.49 per night. (based on HotelPlanner prices)

How much does a 4-5 star hotel near 77221 cost?

In the last year, the average 4 star hotel near 77221 has been $111.54 per night. (based on HotelPlanner prices)

What are the best independent hotels near 77221?

Hotel Zaza Houston Museum District, Scott Inn Suites Downtown Houston and Blossom Houston Medical Center are the best rated independent hotels (not part of a big brand).

What are the most popular Marriott hotels near 77221?

Houston Marriott Medical Center, The Westin Hou Medical Center and Marriott Marquis Houston are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the best IHG hotels near 77221?

Holiday Inn Express Hotel & Suites Houston-Downtown Conv Ctr by I, Holiday Inn Houston S - Nrg Area - Medical Center by IHG and Holiday Inn Houston Downtown by IHG are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

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