Star Rating
Hotel Name
Price Range (USD)to
Amenities

77221 Hotels & Accommodations

Extended Stay America Houston Greenway Plaza - Houston +1-800-230-4134 2330 SW Frwy, Houston, TX 77098 ~1.17 miles west of 77221
  • Economical Downtown property
  • 2 suites in property
From$50
Average 3.5 /5Reviews
Hilton University of Houston +1-800-997-5148 4800 Calhoun Rd., Houston, TX 77004 ~1.41 miles northeast of 77221
  • 4-star Downtown hotel
  • Check in time: 3:00PM
From$91
Very Good 4.0 /5Reviews
Mainstay Suites in Houston +1-888-205-8144 3134 Old Spanish Trail, Houston, TX 77054 ~1.49 miles west of 77221
  • Two-star Convention Center hotel
  • Airport shuttle provided
From$54
Very Good 4.0 /5Read Reviews
Extended Stay Deluxe Houston Medical Center +1-800-997-5149 1301 Braeswood Blvd., Houston, TX 77030 ~2.52 miles west of 77221
  • Three Star Convention Center property
  • Gym is available on property
From$64
Average 3.0 /5Review Score
Hotel Zaza Houston +1-800-230-4134 5701 Main St., Houston, TX 77005 ~2.57 miles northwest of 77221
  • High end Downtown property
  • Check in time: 4:00 PM
From$179
Very Good 4.5 /5Reviews
Lexington Hotel Houston Medical Center - Houston +1-800-997-5148 1025 Swanson St., Houston, TX 77030 ~2.75 miles west of 77221
  • 3-star Downtown hotel
  • Free breakfast
From$75
Very Good 4.0 /5Hotel Reviews
Hotel Icon in Houston +1-888-205-8144 220 Main St., Houston, TX 77002 ~2.79 miles northwest of 77221
  • Four-star Downtown hotel
  • Hotel has 15 suites
From$109
Very Good 4.5 /5Hotel Reviews
Houston Marriott Medical Center +1-800-997-5149 6580 Fannin St., Houston, TX 77030 ~2.80 miles west of 77221
  • Expensive Downtown hotel
  • 26 floors in hotel
From$89
Very Good 4.0 /5Latest Reviews
Hampton Inn & Suites Houston Medical Center +1-800-230-4134 1715 Old Spanish Trail, Houston, TX 77054 ~2.92 miles west of 77221
  • 3 star Convention Center property
  • 37 suites in property
From$69
Very Good 4.5 /5Guest Reviews
Hilton Houston Plaza Medical Center +1-800-997-5148 6633 Travis, Houston, TX 77030 ~2.93 miles west of 77221
  • Three Star Downtown property
  • 145 suites in property
From$209
Very Good 4.0 /5Recent Reviews
Robin's Nest Bed & Breakfast Inn in Houston +1-888-205-8144 4104 Greeley St., Houston, TX 77006 ~2.99 miles northwest of 77221
  • Midscale Downtown hotel
  • Free breakfast available
From$195
Very Good 4.5 /5Guest Reviews
Wyndham Houston Medical Center Hotel & Suite +1-800-997-5149 6800 Main St., Houston, TX 77030 ~2.99 miles west of 77221
  • 3-star Downtown hotel
  • Access to gym on-site
From$85
Very Good 4.0 /5Latest Reviews
Holiday Inn Express & Suites Downtown - Houston +1-800-230-4134 1810 Bell St., Houston, TX 77003 ~3.14 miles north of 77221
  • Affordable Downtown property
  • Hotel has 112 rooms
From$79
Very Good 4.0 /5Recent Reviews
Hilton Americas Houston in Houston +1-800-997-5148 1600 Lamar, Houston, TX 77010 ~3.32 miles north of 77221
  • Four-star Downtown property
  • Hotel has 1200 rooms
From$119
Very Good 4.5 /5Latest Reviews
Springhill Suites by Marriott Houston Nrg Park in Houston +1-888-205-8144 1400 Old Spanish Trail, Houston, TX 77054 ~3.33 miles west of 77221
  • 3 star Downtown hotel
  • 190 rooms in property
From$79
Very Good 4.0 /5Guest Reviews
Athens Hotel +1-800-997-5149 1308 Clay St., Houston, TX 77002 ~3.41 miles north of 77221
  • Economical Downtown property
  • Free breakfast available
From$49
Average 3.0 /5Recent Reviews
Holiday Inn Houston Downtown : 1616 Main St. +1-800-230-4134 1616 Main St., Houston, TX 77002 ~3.46 miles north of 77221
  • Affordable Downtown property
  • Check-in time: 3:00 PM
From$119
Very Good 4.0 /5Guest Reviews
Courtyard by Marriott Houston Medical Center : Houston Medical Center 7702 Main St. +1-800-997-5148 Houston Medical Center 7702 Main St., Houston, TX 77030 ~3.48 miles west of 77221
  • 3-star Suburban hotel
  • Hotel has 3 meeting rooms
From$179
Very Good 4.0 /5Hotel Reviews
Holiday Inn Houston N R G Park Area +1-888-205-8144 8111 Kirby Dr., Houston, TX 77054 ~3.51 miles west of 77221
  • 3 star Suburban hotel
  • 238 sleeping rooms in hotel
From$89
Average 3.5 /5Recent Reviews
Extended Stay America Houston Reliant Pk. La Conch in Houston +1-800-997-5149 1303 La Concha Ln, Houston, TX 77054 ~3.52 miles west of 77221
  • Mid-scale Convention Center property
  • Hotel has 45 suites
From$54
Average 3.0 /5Read Reviews
Four Seasons Hotel Houston +1-800-230-4134 1300 Lamar St., Houston, TX 77010 ~3.52 miles north of 77221
  • Luxury 5 star Downtown property
  • 179 suites in hotel
From$160
Very Good 4.5 /5Hotel Reviews
Moody Manor at the Houston Medical Center in Houston +1-800-997-5148 7706 South Main, Houston, TX 77030 ~3.53 miles west of 77221
  • Cheap Downtown hotel
  • Hotel has 14 suites
From$79
Residence Inn by Marriott Medical Center / Reliant +1-888-205-8144 7710 Main St., Houston, TX 77030 ~3.60 miles west of 77221
  • 3-star Highway hotel
  • Free comp. breakfast
From$75
Average 3.5 /5Review Score
Crowne Plaza Houston Downtown +1-800-997-5149 1700 Smith St., Houston, TX 77002 ~3.62 miles north of 77221
  • 4-star Downtown property
  • Check-in: 12 Noon
From$76
Very Good 4.0 /5Reviews
Rodeway Inn Suites +1-800-230-4134 6712 Morningside Dr., Houston, TX 77030 ~3.63 miles west of 77221
  • 2-star Downtown property
  • Complimentary breakfast is offered
From$75
Terrible 1.5 /5Review Score
Residence Inn Houston Downtown - Houston +1-800-997-5148 904 Dallas St., Houston, TX 77002 ~3.64 miles north of 77221
  • Affordable Downtown hotel
  • Free complimentary breakfast
From$79
Very Good 4.0 /5Reviews
Courtyard Houston Downtown - Houston +1-888-205-8144 916 Dallas St., Houston, TX 77002 ~3.64 miles north of 77221
  • Midscale Downtown property
  • Hotel has 191 rooms
From$89
Average 3.5 /5Hotel Reviews
The Westin Houston Downtown : 1520 Texas Ave. +1-800-997-5149 1520 Texas Ave., Houston, TX 77002 ~3.71 miles north of 77221
  • Expensive Downtown property
  • 4 meeting rooms in hotel
From$149
Very Good 4.0 /5Reviews
Holiday Inn Express Suites Medical Center : 8080 South Main St. +1-800-230-4134 8080 South Main St., Houston, TX 77025 ~3.72 miles west of 77221
  • Affordable Downtown property
  • Check in time: 3:pm
From$104
Very Good 4.0 /5Review Score
Hyatt Regency Houston +1-800-997-5148 1200 Louisiana St., Houston, TX 77002 ~3.78 miles north of 77221
  • Expensive Downtown property
  • 30 meeting rooms in hotel
From$99
Very Good 4.0 /5Guest Reviews
Comfort Suites - Houston +1-888-205-8144 1055 Mcnee Rd., Houston, TX 77054 ~3.82 miles west of 77221
  • Economical Convention Center hotel
  • 50 suites in property
From$65
Average 3.5 /5Reviews
JW Marriott Houston Downtown +1-800-997-5149 806 Main, Houston, TX 77002 ~3.82 miles north of 77221
  • Luxury Five Star property
  • 12 rooms in property
From$219
Very Good 4.5 /5Hotel Reviews
Magnolia Hotel - Houston +1-800-230-4134 1100 Texas Ave., Houston, TX 77002 ~3.84 miles north of 77221
  • Four-star Downtown property
  • 7 conference rooms in property
From$129
Very Good 4.5 /5Reviews
Crowne Plaza Houston Near Reliant Medical : 8686 Kirby Dr. +1-800-997-5148 8686 Kirby Dr., Houston, TX 77054 ~3.86 miles west of 77221
  • Affordable Convention Center property
  • 652 rooms in property
From$99
Average 3.0 /5Recent Reviews
Doubletree Houston Downtown +1-888-205-8144 400 Dallas St., Houston, TX 77002 ~3.89 miles north of 77221
  • Midscale Downtown property
  • 15 meeting rooms in property
From$124
Very Good 4.0 /5Hotel Reviews
The Sam Houston Hotel - Houston +1-800-997-5149 1117 Prairie St., Houston, TX 77002 ~3.91 miles north of 77221
  • High end Downtown property
  • Check-in time: 3:00 PM
From$119
Very Good 4.0 /5Recent Reviews
Best Western Downtown Inn & Suites in Houston +1-800-230-4134 915 West Dallas, Houston, TX 77019 ~3.97 miles north of 77221
  • Affordable Downtown hotel
  • 4 floors in property
From$115
Very Good 4.5 /5Read Reviews
The Quality Inn & Suites Reliant Park - Houston +1-800-997-5148 2364 South Loop West, Houston, TX 77054 ~3.99 miles west of 77221
  • Mid-scale Convention Center hotel
  • Access to gym on-site
From$72
Average 3.0 /5Review Score
The Lancaster Hotel Houston +1-888-205-8144 701 Texas Ave., Houston, TX 77002 ~4.04 miles north of 77221
  • High-end Downtown hotel
  • Hotel has 9 suites
From$119
Very Good 4.5 /5Latest Reviews
Crowne Plaza Houston River Oaks +1-800-997-5149 2712 Southwest Fwy, Houston, TX 77098 ~4.38 miles west of 77221
  • High end Downtown property
  • 355 rooms in property
From$39
Very Good 4.5 /5Hotel Reviews
Residence Inn +1-800-230-4134 2939 Westpark Dr., Houston, TX 77005 ~4.48 miles west of 77221
  • Three Star Downtown hotel
  • Hotel has 4 floors
From$99
Very Good 4.0 /5Reviews
Courtyard by Marriott Houston West University - Houston +1-800-997-5148 2929 Westpark Dr., Houston, TX 77005 ~4.49 miles west of 77221
  • Affordable Suburban hotel
  • Fitness center on property
From$89
Very Good 4.0 /5Latest Reviews
Four Points by Sheraton Houston Greenaway Plaza +1-888-205-8144 2828 Southwest Freeway, Houston, TX 77098 ~4.50 miles west of 77221
  • Affordable Downtown property
  • 9 floors in hotel
From$59
Average 3.0 /5Latest Reviews
Greenway Inn & Suites +1-800-997-5149 2929 Southwest Freeway, Houston, TX 77098 ~4.50 miles west of 77221
  • 2-star Suburban property
  • Hotel has 10 suites
From$25
Terrible 1.5 /5Reviews
La Quinta Inn Reliant / Medical Center +1-800-230-4134 9911 Buffalo Speedway, Houston, TX 77054 ~4.54 miles west of 77221
  • Cheap Downtown property
  • 113 sleeping rooms in hotel
From$49
Average 3.0 /5Recent Reviews
Americas Best Value Inn - Houston +1-800-997-5148 9604 South Main, Houston, TX 77025 ~4.68 miles west of 77221
  • Cheap Convention Center hotel
  • 2 suites in property
From$48
Average 3.5 /5Latest Reviews
Candlewood Suites Extended Stay : 10025 South Main St. +1-888-205-8144 10025 South Main St., Houston, TX 77025 ~4.70 miles west of 77221
  • Cheap Highway property
  • Hotel has 80 suites
From$85
Very Good 4.0 /5Latest Reviews
Carefree Inn at the Medical Center in Houston +1-800-997-5149 10015 South Main St., Houston, TX 77025 ~4.76 miles west of 77221
  • 2-star Downtown property
  • Hotel has 2 floors
From$40
Very Good 4.0 /5Guest Reviews
Motel 6 Houston Reliant Park #1126 in Houston +1-800-230-4134 3223 South Loop West, Houston, TX 77025 ~4.77 miles west of 77221
  • 2-star hotel
  • 3 floors in property
From$45
Poor 2.5 /5Hotel Reviews
Doubletree by Hilton Houston Greenway Plaza +1-800-997-5148 6 Greenway Plaza, Houston, TX 77046 ~5.01 miles west of 77221
  • Four star Highway hotel
  • Gym / Fitness Center Available
From$84
Very Good 4.0 /5Hotel Reviews

Next: Show All Available 77221 Hotels with Pricing
Back to Top