Hotels in 77221 - Houston TX

Only hotels in 77221 zip code are listed below. Search for cheap and discount hotel rates in Houston, TX for your upcoming leisure or conference / group travel. We list the best 77221 hotels and motels so you can review the Houston hotel list below to find the perfect lodging. Hotels in Harris county and area code 713 are also listed.

Star Rating
Hotel Name
Price Range (USD)to
Amenities

77221 Hotels/Accommodations

Extended Stay America Houston Greenway Plaza - Houston
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
2330 Southwest Frwy, Houston, TX 77098 ~1.17 miles west of 77221
  • Two star Downtown property
  • Free breakfast
  • Service is adequate
  • Vibe is not too good
More PhotosExterior of Extended Stay America Houston Greenway Plaza
From$61
Average 3.5 /5Latest Reviews CallBookMore Details
Econo Lodge - Houston
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
3138 Old Spanish Trail, Houston, TX 77054 ~1.37 miles west of 77221
  • Low priced hotel
More Photoshotel room
From$60
Not Good 1.5 /5Read Reviews CallBookMore Details
Hilton University of Houston
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
4800 Calhoun Rd., Houston, TX 77004 ~1.39 miles northeast of 77221
  • High end Downtown hotel
  • Check-in time: 3:00PM
  • Room cleanliness is acceptable
  • Service should be more professional
More PhotosPhoto of Hilton University of Houston
From$91
Very Good 4.0 /5Hotel Reviews CallBookMore Details
Mainstay Suites
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
3134 Old Spanish Trail, Houston, TX 77054 ~1.41 miles west of 77221
  • Low-priced Convention Center hotel
  • 89 rooms in property
  • All guests liked the proximity to shopping
  • Very close to the Medical Center
More PhotosImage of Mainstay Suites
From$60
Very Good 4.0 /5Reviews CallBookMore Details
Americas Best Value Inn Medical Center Downtown
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
2419 Riverside Dr., Houston, TX 77004 ~1.65 miles northwest of 77221
  • Cheap hotel
  • Free complimentary breakfast
More PhotosImage of Americas Best Value Inn Medical Center Downtown
From$60
Average 3.0 /5Latest Reviews CallBookMore Details
Sonder The Hampstead : 1508 Blodgett
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
1508 Blodgett, Houston, TX 77004 ~2.33 miles northwest of 77221
  • Three Star Downtown property
  • 36 rooms in hotel
More PhotosImage of Sonder The Hampstead
From$80
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Scottish Inns & Suites Scott
+1-888-897-9207

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New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
1933 Scott St., Houston, TX 77003 ~2.34 miles north of 77221
  • 3 star hotel
  • 18 sleeping rooms in hotel
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From$90
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Best Way Inn Houston Medical Center
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
3100 Holmes Rd., Houston, TX 77051 ~2.49 miles southwest of 77221
  • Low priced hotel
  • Hotel has 42 rooms
More PhotosPhoto of Best Way Inn Houston Medical Center
From$60
Poor 2.5 /5Recent Reviews CallBookMore Details
Extended Stay Deluxe Houston Medical Center - Houston
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
1301 Braeswood Blvd., Houston, TX 77030 ~2.52 miles west of 77221
  • Mid-scale Convention Center hotel
  • 3 floors in hotel
  • TV needs to be updated
  • Horrible vibe
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From$64
Average 3.0 /5Recent Reviews CallBookMore Details
Hotel Zaza Houston
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
5701 Main St., Houston, TX 77005 ~2.57 miles northwest of 77221
  • Four-star Downtown property
  • Fitness / Gym is on-site
  • Rooms could be larger
  • Desserts & fruits are ok
More PhotosPhoto of Hotel Zaza Houston
From$159
Very Good 4.5 /5Read Reviews CallBookMore Details
Days Inn Univ. of Houston / Downtown : 6190 Gulf Fwy
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
6190 Gulf Fwy, Houston, TX 77023 ~2.73 miles east of 77221
  • Three Star Downtown property
  • 2 floors in hotel
More PhotosExterior of Days Inn Univ. of Houston / Downtown
From$55
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Lexington Hotel Houston Medical Center : 1025 Swanson St.
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
1025 Swanson St., Houston, TX 77030 ~2.78 miles west of 77221
  • Low-priced Downtown property
  • Complimentary breakfast is offered
  • Great parking, according to 100%
  • Great location
More PhotosImage of Lexington Hotel Houston Medical Center
From$60
Average 3.5 /5Review Score CallBookMore Details
Houston Marriott Medical Center in Houston
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
6580 Fannin St., Houston, TX 77030 ~2.80 miles west of 77221
  • Four star Downtown hotel
  • Fitness + Health Center
More PhotosPhoto of Houston Marriott Medical Center
From$75
Very Good 4.5 /5Reviews CallBookMore Details
The Westin Hou Medical Center : 1709 Dryden Rd.
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
1709 Dryden Rd., Houston, TX 77030 ~2.81 miles west of 77221
  • 3 star hotel
  • Gym is available on property
More PhotosImage of The Westin Hou Medical Center
From$90
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Sonder at Mid Main
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
3550 Main St., Houston, TX 77002 ~2.87 miles northwest of 77221
  • 3 star Downtown hotel
  • Check-in: 4:00 pm
More PhotosImage of Sonder at Mid Main
From$75
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Hampton Inn & Suites Houston Medical Center
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
1715 Old Spanish Trail, Houston, TX 77054 ~2.92 miles west of 77221
  • Affordable Convention Center hotel
  • 3 meeting rooms in hotel
More PhotosImage of Hampton Inn & Suites Houston Medical Center
From$69
Very Good 4.0 /5Review Score CallBookMore Details
Hilton Houston Medical Plaza in Houston
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
6633 Travis St., Houston, TX 77030 ~2.93 miles west of 77221
  • Three Star Downtown hotel
  • Hotel has an eco-friendly policy Read more
More PhotosExterior of Hilton Houston Medical Plaza
From$109
Average 3.5 /5Hotel Reviews CallBookMore Details
SureStay Plus Hotel by Best Western Houston Medical Center
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
6700 Main St., Houston, TX 77030-2202 ~2.94 miles west of 77221
  • Three Star Downtown hotel
  • 25 suites in property
More PhotosImage of SureStay Plus Hotel by Best Western Houston Medical Center
From$110
Average 3.5 /5Reviews CallBookMore Details
Intercontinental Houston Medical Ce in Houston
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
6750 Main St., Houston, TX 77030 ~2.95 miles west of 77221
  • Four-star hotel
  • Hotel has 21 floors
More PhotosExterior of Intercontinental Houston Medical Ce
From$160
Very Good 4.5 /5Review Score CallBookMore Details
Robin's Nest Bed & Breakfast Inn : 4104 Greeley St.
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
4104 Greeley St., Houston, TX 77006 ~2.99 miles northwest of 77221
  • Three Star Downtown hotel
  • 2 meeting rooms in hotel
More PhotosExterior of Robin's Nest Bed & Breakfast Inn
From$195
Very Good 4.5 /5Read Reviews CallBookMore Details
Wyndham Houston Medical Center : 6800 Main St.
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
6800 Main St., Houston, TX 77030 ~3.01 miles west of 77221
  • Affordable Downtown property
  • Has environment-friendly policy See more
More PhotosImage of Wyndham Houston Medical Center
From$87
Very Good 4.0 /5Read Reviews CallBookMore Details
Extended Houston Med. Center Ngr Pk. Fannin S (Med
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
7979 Fannin, Houston, TX 77054 ~3.02 miles west of 77221
  • Two-star Convention Center property
  • Check-in: 3pm
  • Service is below average
  • Most guests said rooms were dirty
More PhotosPhoto of Extended Houston Med. Center Ngr Pk. Fannin S (Med
From$49
Poor 2.5 /5Recent Reviews CallBookMore Details
Holiday Inn Express Downtown Convention Center in Houston
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
1810 Bell St., Houston, TX 77003 ~3.11 miles north of 77221
  • Mid-scale Downtown hotel
  • 112 rooms in hotel
  • Bathroom could be optimized
  • Entrance area is ok
More PhotosImage of Holiday Inn Express Downtown Convention Center
From$108
Very Good 4.0 /5Guest Reviews CallBookMore Details
Springhill Suites by Marriott Houston Nrg Park in Houston
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
1400 Old Spanish Trail, Houston, TX 77054 ~3.33 miles west of 77221
  • 3 star Downtown property
  • Free comp. breakfast
  • Good accessibility by car
  • For 67%, the rooms looked old
More PhotosExterior of Springhill Suites by Marriott Houston Nrg Park
From$99
Very Good 4.0 /5Read Reviews CallBookMore Details
Whyhotel Houston Downtown
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
1515 Austin St., Houston, TX 77002 ~3.33 miles north of 77221
  • Mid-scale hotel
  • 103 sleeping rooms in hotel
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From$90
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Athens Hotel & Suites
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
1308 Clay St., Houston, TX 77002 ~3.39 miles north of 77221
  • 3-star Downtown property
  • Free complimentary breakfast
  • Rooms are small
  • Standard TV
More PhotosExterior of Athens Hotel & Suites
From$89
Average 3.0 /5Latest Reviews CallBookMore Details
La Colombe D Or Hotel : 3410 Montrose Blvd.
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
3410 Montrose Blvd., Houston, TX 77006 ~3.41 miles northwest of 77221
  • 3-star hotel
  • Check-in: 16:00
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From$90
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Embassy Suites Houston Downtown
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
1515 Dallas, Houston, TX 77010 ~3.43 miles north of 77221
  • 3-star Downtown property
  • Fitness center on property
More PhotosExterior of Embassy Suites Houston Downtown
From$135
Very Good 4.5 /5Hotel Reviews CallBookMore Details
Sonder Midtown : 306 Mcgowen St.
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
306 Mcgowen St., Houston, TX 77006 ~3.44 miles northwest of 77221
  • Affordable Downtown property
  • Hotel has 11 suites
More PhotosPhoto of Sonder Midtown
From$75
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Holiday Inn Houston Downtown in Houston
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
1616 Main St., Houston, TX 77002 ~3.46 miles north of 77221
  • Affordable Downtown property
  • Hotel has 16 floors
More PhotosPhoto of Holiday Inn Houston Downtown
From$79
Very Good 4.5 /5Review Score CallBookMore Details
Marriott Marquis Houston : 1777 Walker St.
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
1777 Walker St., Houston, TX 77010 ~3.47 miles north of 77221
  • 4-star hotel
  • 40 suites in hotel
More PhotosPhoto of Marriott Marquis Houston
From$150
Very Good 4.5 /5Recent Reviews CallBookMore Details
Sonder Lofts at Ballpark - Houston
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
610 St. Emanuel St. Houston Tx 77003, Houston, TX 77003 ~3.48 miles north of 77221
  • Affordable Downtown hotel
  • Gym / Fitness Center Available
More PhotosExterior of Sonder Lofts at Ballpark
From$100
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Four Seasons Hotel
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
1300 Lamar St., Houston, TX 77010 ~3.51 miles north of 77221
  • Luxury 5 star Downtown hotel
  • 115 suites in property
More PhotosImage of Four Seasons Hotel
From$145
Very Good 4.5 /5Reviews CallBookMore Details
The Reside : 7755 South Main St.
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
7755 South Main St., Houston, TX 77054 ~3.51 miles west of 77221
  • Midscale Downtown hotel
  • Hotel has 3 floors
More PhotosPhoto of The Reside
From$55
Very Good 4.0 /5Hotel Reviews CallBookMore Details
Holiday Inn Houston N R G Park Area
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
8111 Kirby Dr., Houston, TX 77054 ~3.51 miles west of 77221
  • 3 star Suburban hotel
  • Fitness + Health Center
  • Shower can be a problem
  • Breakfast can be improved
More PhotosExterior of Holiday Inn Houston N R G Park Area
From$126
Average 3.5 /5Latest Reviews CallBookMore Details
Extended Stay Deluxe Houston Medical Center La Con : 1303 La Concha Ln
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
1303 La Concha Ln, Houston, TX 77054 ~3.52 miles west of 77221
  • Economy Convention Center hotel
  • 3 floors in hotel
  • Horrible vibe
  • Great shopping
More PhotosPhoto of Extended Stay Deluxe Houston Medical Center La Con
From$41
Very Good 4.0 /5Recent Reviews CallBookMore Details
Residence Inn by Marriott Medical Center / Reliant in Houston
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
7710 Main St., Houston, TX 77030 ~3.54 miles west of 77221
  • Mid-scale Highway hotel
  • Check-in: 3:00pm
  • Rather comfortable
  • Tasty breakfast
More PhotosExterior of Residence Inn by Marriott Medical Center / Reliant
From$69
Average 3.5 /5Hotel Reviews CallBookMore Details
Courtyard by Marriott Houston Medical Center : Houston Medical Center
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
Houston Medical Center, Houston, TX 77030 ~3.55 miles west of 77221
  • 3 star Downtown property
  • 197 rooms in property
More PhotosExterior of Courtyard by Marriott Houston Medical Center
From$109
Very Good 4.0 /5Reviews CallBookMore Details
Bayou City Event Center in Houston
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
9401 Knight Rd., Houston, TX 77045 ~3.56 miles southwest of 77221
  • 2-star hotel
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From$60
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Residence Inn Houston Medical Center
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
7807 Kirby Dr., Houston, TX 77030 ~3.56 miles west of 77221
  • 3 star Downtown hotel
  • Hotel has 182 suites
More PhotosExterior of Residence Inn Houston Medical Center
From$109
Excellent 5.0 /5Hotel Reviews CallBookMore Details
Moody Manor - Houston
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
7706 Main St., Houston, TX 77030 ~3.58 miles west of 77221
  • 3-star Downtown hotel
  • Hotel has 197 suites
More PhotosExterior of Moody Manor
From$69
Average 3.5 /5Read Reviews CallBookMore Details
Hampton Inn Houston Downtown - Houston
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
710 Crawford St., Houston, TX 77002 ~3.58 miles north of 77221
  • 3 star Convention Center hotel
  • 300 rooms in hotel
More PhotosExterior of Hampton Inn Houston Downtown
From$89
Very Good 4.5 /5Reviews CallBookMore Details
Oakwood at Midtown Arbor Place - Houston
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
10 Oak Court, Houston, TX 77006 ~3.58 miles north of 77221
  • Midscale hotel
  • Gym is available on property
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From$90
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Hotel Alessandra - Houston
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
1070 Dallas St., Houston, TX 77002 ~3.59 miles north of 77221
  • Luxurious Five Star Downtown property
  • 4 suites in property
More PhotosImage of Hotel Alessandra
From$150
Excellent 5.0 /5Hotel Reviews CallBookMore Details
Rodeway Inn & Suites Medical Center : 6712 Morningside Dr.
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
6712 Morningside Dr., Houston, TX 77030 ~3.60 miles west of 77221
  • Low priced Downtown property
  • 33 rooms in hotel
  • Almost all guests found problems with the furniture
  • Furniture needs more attention
More PhotosImage of Rodeway Inn & Suites Medical Center
From$60
Average 3.5 /5Guest Reviews CallBookMore Details
The Whitehall Houston
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
1700 Smith St., Houston, TX 77002 ~3.62 miles north of 77221
  • Four star Downtown property
  • Check in time: 12 Noon
More PhotosPhoto of The Whitehall Houston
From$109
Very Good 4.5 /5Latest Reviews CallBookMore Details
Americas Best Value Inn Near Nrg Park / Medical Center in Houston
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
7905 South Main St., Houston, TX 77025 ~3.63 miles west of 77221
  • Low priced hotel
  • 2 floors in property
More PhotosPhoto of Americas Best Value Inn Near Nrg Park / Medical Center
From$72
Average 3.0 /5Recent Reviews CallBookMore Details
Residence Inn Houston Downtown / Convention Center - Houston
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
904 Dallas St., Houston, TX 77002 ~3.64 miles north of 77221
  • Midscale Downtown hotel
  • Hotel has 171 rooms
More PhotosImage of Residence Inn Houston Downtown / Convention Center
From$99
Very Good 4.0 /5Review Score CallBookMore Details
Courtyard Houston Downtown / Convention Center : 916 Dallas St.
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
916 Dallas St., Houston, TX 77002 ~3.64 miles north of 77221
  • Three Star Downtown property
  • Hotel has 191 rooms
More PhotosExterior of Courtyard Houston Downtown / Convention Center
From$99
Very Good 4.0 /5Reviews CallBookMore Details
Springhill Suites Houston Downtown - Houston
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
914 Dallas St., Houston, TX 77002 ~3.65 miles north of 77221
  • Midscale Downtown hotel
  • Hotel has 167 suites
More PhotosExterior of Springhill Suites Houston Downtown
From$99
Very Good 4.0 /5Recent Reviews CallBookMore Details

Next: Show All Available 77221 Hotels with Pricing

Graph: Upcoming 20 Days of Houston Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Houston, TX discounts available. The chart reflects the cheapest Houston hotel for each day and each star rating category.

FAQs about hotels near 77221

What are the best rated hotels near 77221?

Residence Inn Houston Medical Center, Hotel Alessandra and Hotel Zaza Houston are the best rated hotels based on customer reviews in the last 365 days.

What are the top luxurious hotels near 77221?

Four Seasons Hotel, Hotel Alessandra and Hilton University of Houston are the top 3 luxury hotels near 77221.

What hotels are closest to the area of 77221?

Extended Stay America Houston Greenway Plaza, Econo Lodge, and Hilton University of Houston are the properties closest to 77221.

How much does a cheap hotel near 77221 cost per night?

In the last year, a 2 star hotel near 77221 can be as cheap as $63.37 per night. (based on HotelPlanner prices)

How much does a 3 star hotel near 77221 cost per night?

In the last year, the average 3 star hotel near 77221 has been $85.49 per night. (based on HotelPlanner prices)

How much does a 4-5 star hotel near 77221 cost?

In the last year, the average 4 star hotel near 77221 has been $111.54 per night. (based on HotelPlanner prices)

What are the best independent hotels near 77221?

Hotel Alessandra, Hotel Zaza Houston and Robin's Nest Bed & Breakfast Inn are the best rated independent hotels (not part of a big brand).

What are the best Marriott hotels near 77221?

Residence Inn Houston Medical Center, Houston Marriott Medical Center and Marriott Marquis Houston are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the best Choice Hotels branded hotels near 77221?

Mainstay Suites, Rodeway Inn & Suites Medical Center and Econo Lodge are the best rated Choice Hotels branded hotels (based on HotelPlanner reviews score).

What are the most popular IHG hotels near 77221?

Intercontinental Houston Medical Ce, Holiday Inn Houston Downtown and Holiday Inn Express Downtown Convention Center are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

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