Hotels in 77221 - Houston TX

Only hotels in 77221 zip code are listed below. Search for cheap and discount hotel rates in Houston, TX for your upcoming leisure or conference / group travel. We list the best 77221 hotels and motels so you can review the Houston hotel list below to find the perfect lodging. Hotels in Harris county and area code 713 are also listed.


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77221 Hotels, Motels & Accommodations

Photo of Extended Stay America Houston Greenway PlazaExtended Stay America Houston Greenway Plaza - Houston
+1-800-230-4134Check Rates
2330 SW Frwy, Houston, TX 77098
  • 3.5/5, Average Recent Reviews
  • Low priced Downtown property
  • Hotel has 2 suites
~1.17 Miles from 77221
Image of Hilton University of HoustonHilton University of Houston in Houston
+1-800-997-5148Check Rates
4800 Calhoun Rd., Houston, TX 77004
  • 4.0/5, Very Good Guest Reviews
  • Four-star Downtown hotel
  • 12 suites in hotel
~1.41 Miles from 77221
Image of Mainstay SuitesMainstay Suites in Houston
+1-800-997-5149Check Rates
3134 Old Spanish Trail, Houston, TX 77054
  • 4.0/5, Very Good Guest Reviews
  • Cheap Convention Center hotel
  • 92 suites in hotel
~1.49 Miles from 77221
Extended Stay Deluxe Houston Medical Center in Houston
+1-800-230-4134Check Rates
1301 Braeswood Blvd., Houston, TX 77030
  • 3.0/5, Average Review Score
  • Mid-scale Convention Center property
  • Check in: 3:00pm
~2.52 Miles from 77221
Exterior of Hotel Zaza HoustonHotel Zaza Houston
+1-800-997-5148Check Rates
5701 Main St., Houston, TX 77005
  • 4.5/5, Very Good Guest Reviews
  • High-end Downtown hotel
  • 315 sleeping rooms in hotel
~2.57 Miles from 77221
Image of Lexington Hotel Houston Medical CenterLexington Hotel Houston Medical Center
+1-800-997-5149Check Rates
1025 Swanson St., Houston, TX 77030
  • 3 star Downtown hotel
  • 38 rooms in property
~2.75 Miles from 77221
Image of Hotel IconHotel Icon
+1-800-230-4134Check Rates
220 Main St., Houston, TX 77002
  • 4 star Downtown property
  • 135 sleeping rooms in hotel
~2.79 Miles from 77221
Photo of Houston Marriott Medical CenterHouston Marriott Medical Center
+1-800-997-5148Check Rates
6580 Fannin St., Houston, TX 77030
  • 4-star Downtown hotel
  • 386 rooms in property
~2.80 Miles from 77221
Hampton Inn & Suites Houston Medical Center
+1-800-997-5149Check Rates
1715 Old Spanish Trail, Houston, TX 77054
  • 4.5/5, Very Good Hotel Reviews
  • 3 star Convention Center hotel
  • 120 rooms in hotel
~2.92 Miles from 77221
Hilton Houston Plaza Medical Center - Houston
+1-800-230-4134Check Rates
6633 Travis, Houston, TX 77030
  • 4.0/5, Very Good Latest Reviews
  • Midscale Downtown hotel
  • 9 meeting rooms in hotel
~2.93 Miles from 77221
Robin's Nest Bed & Breakfast Inn
+1-800-997-5148Check Rates
4104 Greeley St., Houston, TX 77006
  • Affordable Downtown hotel
  • 10 sleeping rooms in hotel
~2.99 Miles from 77221
Wyndham Houston Medical Center Hotel & Suite in Houston
+1-800-997-5149Check Rates
6800 Main St., Houston, TX 77030~2.99 Miles from 77221
Holiday Inn Express & Suites Downtown
+1-800-230-4134Check Rates
1810 Bell St., Houston, TX 77003
  • 4.0/5, Very Good Read Reviews
  • Midscale Downtown hotel
  • 4 floors in hotel
~3.14 Miles from 77221
Hilton Americas Houston
+1-800-997-5148Check Rates
1600 Lamar, Houston, TX 77010
  • 4.5/5, Very Good Review Score
  • High-end Downtown hotel
  • 24 floors in hotel
~3.32 Miles from 77221
Springhill Suites by Marriott Houston Nrg Park in Houston
+1-800-997-5149Check Rates
1400 Old Spanish Trail, Houston, TX 77054
  • Affordable Downtown hotel
  • Check in time: 3:00PM
~3.33 Miles from 77221
Athens Hotel
+1-800-230-4134Check Rates
1308 Clay St., Houston, TX 77002
  • 3.0/5, Average Read Reviews
  • Two-star Downtown hotel
  • Check-in time: 2PM
~3.41 Miles from 77221
Courtyard by Marriott Houston Medical Center - Houston
+1-800-997-5148Check Rates
Houston Medical Center 7702 Main St., Houston, TX 77030
  • 4.0/5, Very Good Recent Reviews
  • Affordable Suburban hotel
  • 8 suites in hotel
~3.48 Miles from 77221
Holiday Inn Houston N R G Park Area : 8111 Kirby Dr.
+1-800-997-5149Check Rates
8111 Kirby Dr., Houston, TX 77054
  • 3.5/5, Average Guest Reviews
  • Affordable Suburban property
  • 3 conference rooms in property
~3.51 Miles from 77221
Extended Stay America Houston Reliant Pk. La Conch : 1303 La Concha Ln
+1-800-230-4134Check Rates
1303 La Concha Ln, Houston, TX 77054
  • 3.0/5, Average Read Reviews
  • Midscale Convention Center hotel
  • Check-in time: 3pm
~3.52 Miles from 77221
Four Seasons Hotel Houston : 1300 Lamar St.
+1-800-997-5148Check Rates
1300 Lamar St., Houston, TX 77010
  • 4.5/5, Very Good Reviews
  • Luxurious 5-star Downtown hotel
  • Check-in time: 3:00 p.m.
~3.52 Miles from 77221
Moody Manor at the Houston Medical Center - Houston
+1-800-997-5149Check Rates
7706 South Main, Houston, TX 77030
  • 2-star Downtown property
  • Check in: 3:00pm
~3.53 Miles from 77221
Residence Inn by Marriott Medical Center / Reliant
+1-800-230-4134Check Rates
7710 Main St., Houston, TX 77030
  • 3.5/5, Average Reviews
  • Affordable Highway property
  • Free complimentary breakfast
~3.60 Miles from 77221
Crowne Plaza Houston Downtown
+1-800-997-5148Check Rates
1700 Smith St., Houston, TX 77002
  • Expensive Downtown hotel
  • Gym / Fitness Center Available
~3.62 Miles from 77221
Rodeway Inn Suites
+1-800-997-5149Check Rates
6712 Morningside Dr., Houston, TX 77030
  • Two-star Downtown hotel
  • 33 rooms in property
~3.63 Miles from 77221
Residence Inn Houston Downtown - Houston
+1-800-230-4134Check Rates
904 Dallas St., Houston, TX 77002
  • 4.0/5, Very Good Hotel Reviews
  • Affordable Downtown property
  • 171 rooms in hotel
~3.64 Miles from 77221
Courtyard Houston Downtown
+1-800-997-5148Check Rates
916 Dallas St., Houston, TX 77002
  • 3.5/5, Average Latest Reviews
  • Three Star Downtown property
  • 9 floors in property
~3.64 Miles from 77221
The Westin Houston Downtown : 1520 Texas Ave.
+1-800-997-5149Check Rates
1520 Texas Ave., Houston, TX 77002
  • 4.0/5, Very Good Guest Reviews
  • 4-star Downtown property
  • 4 meeting rooms in hotel
~3.71 Miles from 77221
Holiday Inn Express Suites Medical Center in Houston
+1-800-230-4134Check Rates
8080 South Main St., Houston, TX 77025
  • 4.0/5, Very Good Read Reviews
  • Mid-scale Downtown property
  • 79 rooms in hotel
~3.72 Miles from 77221
Hyatt Regency Houston - Houston
+1-800-997-5148Check Rates
1200 Louisiana St., Houston, TX 77002
  • 4.0/5, Very Good Recent Reviews
  • 4-star Downtown hotel
  • Hotel has 30 meeting rooms
~3.78 Miles from 77221
Comfort Suites
+1-800-997-5149Check Rates
1055 Mcnee Rd., Houston, TX 77054
  • 3.5/5, Average Recent Reviews
  • 2-star Convention Center hotel
  • Hotel has 50 suites
~3.82 Miles from 77221
JW Marriott Houston Downtown in Houston
+1-800-230-4134Check Rates
806 Main, Houston, TX 77002
  • Luxurious 5-star property
~3.82 Miles from 77221
Magnolia Hotel - Houston
+1-800-997-5148Check Rates
1100 Texas Ave., Houston, TX 77002
  • 4.5/5, Very Good Latest Reviews
  • Expensive Downtown property
  • 7 meeting rooms in hotel
~3.84 Miles from 77221
Crowne Plaza Houston Near Reliant Medical
+1-800-997-5149Check Rates
8686 Kirby Dr., Houston, TX 77054
  • Midscale Convention Center property
  • Fitness / Gym is on-site
~3.86 Miles from 77221
Doubletree Houston Downtown - Houston
+1-800-230-4134Check Rates
400 Dallas St., Houston, TX 77002
  • 4.0/5, Very Good Guest Reviews
  • Midscale Downtown hotel
  • 20 floors in hotel
~3.89 Miles from 77221
The Sam Houston Hotel - Houston
+1-800-997-5148Check Rates
1117 Prairie St., Houston, TX 77002
  • 4.0/5, Very Good Hotel Reviews
  • 4 star Downtown hotel
  • Hotel has 10 floors
~3.91 Miles from 77221
Best Western Downtown Inn & Suites in Houston
+1-800-997-5149Check Rates
915 West Dallas, Houston, TX 77019
  • 4.5/5, Very Good Hotel Reviews
  • 3 star Downtown property
  • Check-in: 2:00PM
~3.97 Miles from 77221
The Quality Inn & Suites Reliant Park - Houston
+1-800-230-4134Check Rates
2364 South Loop West, Houston, TX 77054
  • 3.5/5, Average Read Reviews
  • Midscale Convention Center property
  • 106 sleeping rooms in hotel
~3.99 Miles from 77221
The Lancaster Hotel Houston - Houston
+1-800-997-5148Check Rates
701 Texas Ave., Houston, TX 77002
  • 4 star Downtown hotel
  • 9 suites in hotel
~4.04 Miles from 77221
Crowne Plaza Houston River Oaks in Houston
+1-800-997-5149Check Rates
2712 Southwest Fwy, Houston, TX 77098
  • 4.5/5, Very Good Guest Reviews
  • High end Downtown hotel
  • Check-in time: 3:00 PM
~4.38 Miles from 77221
Residence Inn
+1-800-230-4134Check Rates
2939 Westpark Dr., Houston, TX 77005
  • 4.0/5, Very Good Guest Reviews
  • Midscale Downtown property
  • Access to gym on-site
~4.48 Miles from 77221
Courtyard by Marriott Houston West University in Houston
+1-800-997-5148Check Rates
2929 Westpark Dr., Houston, TX 77005
  • 4.0/5, Very Good Reviews
  • Mid-scale Suburban hotel
  • Hotel has 100 rooms
~4.49 Miles from 77221
Four Points by Sheraton Houston Greenaway Plaza
+1-800-997-5149Check Rates
2828 Southwest Freeway, Houston, TX 77098
  • Three Star Downtown hotel
  • 216 rooms in hotel
~4.50 Miles from 77221
Greenway Inn & Suites
+1-800-230-4134Check Rates
2929 Southwest Freeway, Houston, TX 77098
  • 1.5/5, Terrible Hotel Reviews
  • Economical Suburban property
  • Check in time: 1:00 PM
~4.50 Miles from 77221
La Quinta Inn Reliant / Medical Center : 9911 Buffalo Speedway
+1-800-997-5148Check Rates
9911 Buffalo Speedway, Houston, TX 77054
  • 3.0/5, Average Guest Reviews
  • Inexpensive Downtown property
  • Free complimentary breakfast
~4.54 Miles from 77221
Americas Best Value Inn - Houston
+1-800-997-5149Check Rates
9604 South Main, Houston, TX 77025
  • 3.5/5, Average Guest Reviews
  • Economy Convention Center hotel
  • Check in time: 1:00 PM
~4.68 Miles from 77221
Candlewood Suites Extended Stay
+1-800-230-4134Check Rates
10025 South Main St., Houston, TX 77025
  • 3 star Highway hotel
  • 4 floors in hotel
~4.70 Miles from 77221
Executive Inn & Suites
+1-800-997-5148Check Rates
6711 Telephone Rd., Houston, TX 77061~4.75 Miles from 77221
Carefree Inn at the Medical Center - Houston
+1-800-997-5149Check Rates
10015 South Main St., Houston, TX 77025
  • 4.0/5, Very Good Guest Reviews
  • Economy Downtown hotel
  • 2 floors in hotel
~4.76 Miles from 77221
Motel 6 Houston Reliant Park #1126 in Houston
+1-800-230-4134Check Rates
3223 South Loop West, Houston, TX 77025
  • Low priced hotel
  • 3 floors in hotel
~4.77 Miles from 77221
Doubletree by Hilton Houston Greenway Plaza
+1-800-997-5148Check Rates
6 Greenway Plaza, Houston, TX 77046
  • High end Highway property
  • 26 meeting rooms in hotel
~5.01 Miles from 77221



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