Hotels in 77221 - Houston TX

Only hotels in 77221 zip code are listed below. Search for cheap and discount hotel rates in Houston, TX for your upcoming leisure or conference / group travel. We list the best 77221 hotels and motels so you can review the Houston hotel list below to find the perfect lodging. Hotels in Harris county and area code 713 are also listed.


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77221 Hotels & Accommodations

Image of Extended Stay America Houston Greenway PlazaExtended Stay America Houston Greenway Plaza in Houston
+1-800-230-4134
$50+

2330 SW Frwy, Houston, TX 77098
  • 3.5/5, Average Reviews
  • Inexpensive Downtown hotel
  • Hotel has 2 suites
~1.17 Miles from 77221
Image of Hilton University of HoustonHilton University of Houston
+1-800-997-5148
$91+

4800 Calhoun Rd., Houston, TX 77004
  • 4.0/5, Very Good Reviews
  • Expensive Downtown property
  • Hotel has 12 suites
~1.41 Miles from 77221
Image of Mainstay SuitesMainstay Suites
+1-800-997-5149
$54+

3134 Old Spanish Trail, Houston, TX 77054
  • 4.0/5, Very Good Review Score
  • Cheap Convention Center hotel
  • 92 suites in hotel
~1.49 Miles from 77221
Extended Stay Deluxe Houston Medical Center
+1-800-230-4134
$64+

1301 Braeswood Blvd., Houston, TX 77030
  • 3.0/5, Average Read Reviews
  • 3-star Convention Center property
  • Fitness / Gym is on-site
~2.52 Miles from 77221
Photo of Hotel Zaza HoustonHotel Zaza Houston
+1-800-997-5148
$179+

5701 Main St., Houston, TX 77005
  • 4.5/5, Very Good Read Reviews
  • 4-star Downtown property
  • 75 suites in hotel
~2.57 Miles from 77221
Exterior of Lexington Hotel Houston Medical CenterLexington Hotel Houston Medical Center : 1025 Swanson St.
+1-800-997-5149
$75+

1025 Swanson St., Houston, TX 77030
  • 3 star Downtown hotel
  • Hotel has 38 rooms
~2.75 Miles from 77221
Image of Hotel IconHotel Icon in Houston
+1-800-230-4134
$109+

220 Main St., Houston, TX 77002
  • 4-star Downtown property
  • Hotel has 6 meeting rooms
~2.79 Miles from 77221
Photo of Houston Marriott Medical CenterHouston Marriott Medical Center in Houston
+1-800-997-5148
$89+

6580 Fannin St., Houston, TX 77030
  • High-end Downtown property
  • 26 floors in hotel
~2.80 Miles from 77221
Hampton Inn & Suites Houston Medical Center : 1715 Old Spanish Trail
+1-800-997-5149
$69+

1715 Old Spanish Trail, Houston, TX 77054
  • 4.5/5, Very Good Latest Reviews
  • Mid-scale Convention Center hotel
  • 5 floors in property
~2.92 Miles from 77221
Hilton Houston Plaza Medical Center - Houston
+1-800-230-4134
$209+

6633 Travis, Houston, TX 77030
  • 4.0/5, Very Good Latest Reviews
  • Mid-scale Downtown property
  • 145 suites in property
~2.93 Miles from 77221
Robin's Nest Bed & Breakfast Inn in Houston
+1-800-997-5148
$195+

4104 Greeley St., Houston, TX 77006
  • 3 star Downtown property
  • 10 rooms in property
~2.99 Miles from 77221
Wyndham Houston Medical Center Hotel & Suite in Houston
+1-800-997-5149
$85+

6800 Main St., Houston, TX 77030
  • 4.0/5, Very Good Hotel Reviews
  • 3 star Downtown hotel
  • 215 suites in property
~2.99 Miles from 77221
Holiday Inn Express & Suites Downtown - Houston
+1-800-230-4134
$79+

1810 Bell St., Houston, TX 77003
  • 4.0/5, Very Good Guest Reviews
  • 3 star Downtown property
  • Check in: 3:00pm
~3.14 Miles from 77221
Hilton Americas Houston
+1-800-997-5148
$119+

1600 Lamar, Houston, TX 77010
  • 4.5/5, Very Good Read Reviews
  • Four star Downtown property
  • Fitness / Gym is on-site
~3.32 Miles from 77221
Springhill Suites by Marriott Houston Nrg Park
+1-800-997-5149
$79+

1400 Old Spanish Trail, Houston, TX 77054
  • Three Star Downtown hotel
  • 190 rooms in hotel
~3.33 Miles from 77221
Athens Hotel
+1-800-230-4134
$49+

1308 Clay St., Houston, TX 77002
  • 3.0/5, Average Latest Reviews
  • Two star Downtown hotel
  • Check-in time: 2PM
~3.41 Miles from 77221
Holiday Inn Houston Downtown - Houston
+1-800-997-5148
$129+

1616 Main St., Houston, TX 77002
  • 3 star Downtown property
  • 213 rooms in property
~3.46 Miles from 77221
Courtyard by Marriott Houston Medical Center - Houston
+1-800-997-5149
$179+

Houston Medical Center 7702 Main St., Houston, TX 77030
  • 4.0/5, Very Good Review Score
  • 3-star Suburban property
  • 8 floors in hotel
~3.48 Miles from 77221
Holiday Inn Houston N R G Park Area - Houston
+1-800-230-4134
$89+

8111 Kirby Dr., Houston, TX 77054
  • 3.5/5, Average Hotel Reviews
  • Midscale Suburban hotel
  • 3 meeting rooms in property
~3.51 Miles from 77221
Extended Stay America Houston Reliant Pk. La Conch
+1-800-997-5148
$54+

1303 La Concha Ln, Houston, TX 77054
  • 3.0/5, Average Read Reviews
  • Affordable Convention Center hotel
  • Hotel has 3 floors
~3.52 Miles from 77221
Four Seasons Hotel Houston - Houston
+1-800-997-5149
$175+

1300 Lamar St., Houston, TX 77010
  • 4.5/5, Very Good Review Score
  • Luxury Five Star Downtown property
  • Airport shuttle provided
~3.52 Miles from 77221
Moody Manor at the Houston Medical Center in Houston
+1-800-230-4134
$79+

7706 South Main, Houston, TX 77030
  • Cheap Downtown hotel
  • 14 suites in property
~3.53 Miles from 77221
Residence Inn by Marriott Medical Center / Reliant - Houston
+1-800-997-5148
$90+

7710 Main St., Houston, TX 77030
  • 3.5/5, Average Read Reviews
  • Midscale Highway property
  • Hotel has 287 suites
~3.60 Miles from 77221
Crowne Plaza Houston Downtown : 1700 Smith St.
+1-800-997-5149
$76+

1700 Smith St., Houston, TX 77002
  • Expensive Downtown property
  • 13 meeting rooms in hotel
~3.62 Miles from 77221
Rodeway Inn Suites
+1-800-230-4134
$75+

6712 Morningside Dr., Houston, TX 77030
  • Low-priced Downtown hotel
  • Free breakfast available
~3.63 Miles from 77221
Courtyard Houston Downtown
+1-800-997-5148
$89+

916 Dallas St., Houston, TX 77002
  • 3.5/5, Average Hotel Reviews
  • Affordable Downtown property
  • 9 floors in hotel
~3.64 Miles from 77221
Residence Inn Houston Downtown in Houston
+1-800-997-5149
$79+

904 Dallas St., Houston, TX 77002
  • 4.0/5, Very Good Guest Reviews
  • Midscale Downtown property
  • Free comp. breakfast
~3.64 Miles from 77221
The Westin Houston Downtown - Houston
+1-800-230-4134
$149+

1520 Texas Ave., Houston, TX 77002
  • 4.0/5, Very Good Hotel Reviews
  • High-end Downtown hotel
  • Hotel has 12 floors
~3.71 Miles from 77221
Holiday Inn Express Suites Medical Center
+1-800-997-5148
$104+

8080 South Main St., Houston, TX 77025
  • 4.0/5, Very Good Hotel Reviews
  • Midscale Downtown property
  • Check-in: 3:pm
~3.72 Miles from 77221
Hyatt Regency Houston
+1-800-997-5149
$99+

1200 Louisiana St., Houston, TX 77002
  • 4.0/5, Very Good Reviews
  • Four star Downtown property
  • Check-in: 3:00 pm
~3.78 Miles from 77221
Comfort Suites - Houston
+1-800-230-4134
$65+

1055 Mcnee Rd., Houston, TX 77054
  • 3.5/5, Average Hotel Reviews
  • Low priced Convention Center hotel
  • Check in time: 3pm
~3.82 Miles from 77221
JW Marriott Houston Downtown
+1-800-997-5148
$219+

806 Main, Houston, TX 77002
  • Luxury 5 star hotel
  • 22 floors in hotel
~3.82 Miles from 77221
Magnolia Hotel
+1-800-997-5149
$120+

1100 Texas Ave., Houston, TX 77002
  • 4.5/5, Very Good Reviews
  • Four-star Downtown hotel
  • Check-in: 3:00 PM
~3.84 Miles from 77221
Crowne Plaza Houston Near Reliant Medical - Houston
+1-800-230-4134
$99+

8686 Kirby Dr., Houston, TX 77054
  • 3-star Convention Center property
  • Hotel has 70 suites
~3.86 Miles from 77221
Doubletree Houston Downtown : 400 Dallas St.
+1-800-997-5148
$124+

400 Dallas St., Houston, TX 77002
  • 4.0/5, Very Good Latest Reviews
  • Three Star Downtown property
  • Fitness center on property
~3.89 Miles from 77221
The Sam Houston Hotel : 1117 Prairie St.
+1-800-997-5149
$119+

1117 Prairie St., Houston, TX 77002~3.91 Miles from 77221
Best Western Downtown Inn & Suites
+1-800-230-4134
$115+

915 West Dallas, Houston, TX 77019~3.97 Miles from 77221
The Quality Inn & Suites Reliant Park
+1-800-997-5148
$72+

2364 South Loop West, Houston, TX 77054
  • 3.0/5, Average Recent Reviews
  • Mid-scale Convention Center property
  • 106 sleeping rooms in hotel
~3.99 Miles from 77221
The Lancaster Hotel Houston : 701 Texas Ave.
+1-800-997-5149
$119+

701 Texas Ave., Houston, TX 77002
  • 4-star Downtown property
  • 93 sleeping rooms in hotel
~4.04 Miles from 77221
Crowne Plaza Houston River Oaks - Houston
+1-800-230-4134
$39+

2712 Southwest Fwy, Houston, TX 77098
  • 4.5/5, Very Good Recent Reviews
  • High-end Downtown property
  • 11 meeting rooms in hotel
~4.38 Miles from 77221
Residence Inn
+1-800-997-5148
$99+

2939 Westpark Dr., Houston, TX 77005
  • 4.0/5, Very Good Recent Reviews
  • Midscale Downtown property
  • Check in time: 03:00pm
~4.48 Miles from 77221
Courtyard by Marriott Houston West University : 2929 Westpark Dr.
+1-800-997-5149
$89+

2929 Westpark Dr., Houston, TX 77005
  • 4.0/5, Very Good Latest Reviews
  • 3 star Suburban hotel
  • Fitness + Health Center
~4.49 Miles from 77221
Four Points by Sheraton Houston Greenaway Plaza
+1-800-230-4134
$59+

2828 Southwest Freeway, Houston, TX 77098
  • 3-star Downtown hotel
  • Access to gym on-site
~4.50 Miles from 77221
Greenway Inn & Suites - Houston
+1-800-997-5148
$25+

2929 Southwest Freeway, Houston, TX 77098
  • 1.5/5, Terrible Recent Reviews
  • 2 star Suburban hotel
  • 4 floors in property
~4.50 Miles from 77221
La Quinta Inn Reliant / Medical Center
+1-800-997-5149
$49+

9911 Buffalo Speedway, Houston, TX 77054
  • 3.0/5, Average Hotel Reviews
  • 2-star Downtown hotel
  • Complimentary breakfast is offered
~4.54 Miles from 77221
Americas Best Value Inn : 9604 South Main
+1-800-230-4134
$48+

9604 South Main, Houston, TX 77025
  • 3.5/5, Average Guest Reviews
  • Inexpensive Convention Center hotel
  • 2 suites in property
~4.68 Miles from 77221
Candlewood Suites Extended Stay in Houston
+1-800-997-5148
$85+

10025 South Main St., Houston, TX 77025
  • Cheap Highway hotel
  • Access to gym on-site
~4.70 Miles from 77221
Executive Inn & Suites
+1-800-997-5149
$40+

6711 Telephone Rd., Houston, TX 77061~4.75 Miles from 77221
Carefree Inn at the Medical Center - Houston
+1-800-230-4134
$40+

10015 South Main St., Houston, TX 77025
  • 4.0/5, Very Good Read Reviews
  • Low priced Downtown hotel
  • 2 floors in property
~4.76 Miles from 77221
Motel 6 Houston Reliant Park #1126
+1-800-997-5148
$45+

3223 South Loop West, Houston, TX 77025
  • Low Cost hotel
  • 3 floors in property
~4.77 Miles from 77221



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