Hotels in 77221 - Houston TX

Only hotels in 77221 zip code are listed below. Search for cheap and discount hotel rates in Houston, TX for your upcoming leisure or conference / group travel. We list the best 77221 hotels and motels so you can review the Houston hotel list below to find the perfect lodging. Hotels in Harris county and area code 713 are also listed.

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77221 Hotels/Motels & Accommodations

Cliù Luxury Boutique Condo Hotel : 3144 Southmore Blvd. Unit 10 3144 Southmore Blvd. Unit 10, Houston, TX 77004
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~1.13 miles northwest of 77221
  • High end Downtown hotel
  • Check-in: 4:00pm CST
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From$100
Average 3.0 /5 Guest Reviews Call BookMore Details
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Extended Stay America Suites Houston Med Ctr Greenway Plaza : 2330 Southwest Frwy 2330 Southwest Frwy, Houston, TX 77098
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~1.16 miles west of 77221
  • Economy Downtown hotel
  • Check in time: 3:00 PM
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From$61
Average 3.0 /5 Review Score Call BookMore Details
Summit Inn - Houston Medical Center 3138 Old Spanish Trail, Houston, TX 77054
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~1.37 miles west of 77221
  • 2-star property
  • Check-in: 11:00
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From$60
Average 3.0 /5 Review Score Call BookMore Details
Mainstay Suites Texas Medical Center / Reliant Park 3134 Old Spanish Trail, Houston, TX 77054
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~1.41 miles west of 77221
  • Low-priced Convention Center property
  • Check in: 11:00
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From$60
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Hilton University of Houston : 4800 Calhoun Rd. 4800 Calhoun Rd., Houston, TX 77004
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~1.54 miles northeast of 77221
  • 4-star Downtown property
  • Gym / Fitness Center Available
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From$125
Average 3.0 /5 Hotel Reviews Call BookMore Details
Americas Best Value Inn Medical Center Downtown 2419 Riverside Dr., Houston, TX 77004
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~1.64 miles northwest of 77221
  • 2 star hotel
  • Free breakfast available
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From$60
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Home2 Suites 6840 Almeda Rd., Houston, TX 77030
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~1.81 miles west of 77221
  • Three Star Suburban hotel
  • Fitness / Gym is on-site
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From$99
Excellent 5.0 /5 Latest Reviews Call BookMore Details
Hilton Garden Inn 6840b Almeda Rd., Houston, TX 77030
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~1.81 miles west of 77221
  • Three Star Suburban property
  • Check in: 3:00 PM
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From$109
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Hilton Garden : 6840 B Almeda Rd. 6840 B Almeda Rd., Houston, TX 77030
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~1.82 miles west of 77221
  • Three Star property
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From$80
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Medical District : 2700 Old Spanish Trail 2700 Old Spanish Trail, Houston, TX 77021
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~1.92 miles west of 77221
  • High end property
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From$75
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Sonder The Hampstead 1508 Blodgett, Houston, TX 77004
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~2.32 miles northwest of 77221
  • 3 star Downtown property
  • 36 suites in property
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From$80
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Scott Inn Suites Downtown Houston 1933 Scott St., Houston, TX 77003
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~2.34 miles north of 77221
  • Affordable property
  • 2 floors in property
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From$90
Very Good 4.0 /5 Review Score Call BookMore Details
Best Way Inn Houston - Medical Center - Houston 3100 Holmes Rd., Houston, TX 77051
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~2.49 miles southwest of 77221
  • Inexpensive property
  • 42 sleeping rooms in hotel
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From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
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Extended Stay America Suites Houston Med Ctr Braeswood Bl 1301 Braeswood Blvd., Houston, TX 77030
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~2.52 miles west of 77221
  • Mid-scale Convention Center hotel
  • 3 floors in hotel
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From$64
Average 3.0 /5 Review Score Call BookMore Details
Hotel Zaza Houston Museum District 5701 Main St., Houston, TX 77005
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~2.57 miles northwest of 77221
  • High-end Downtown hotel
  • Hotel has 315 rooms
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From$159
Very Good 4.5 /5 Review Score Call BookMore Details
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Blossom Houston Medical Center - Houston 7114 Bertner Ave., Houston, TX 77030
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~2.68 miles west of 77221
  • Affordable hotel
  • Check in: 16:00
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From$90
Very Good 4.0 /5 Reviews Call BookMore Details
Blossom Hotel Houston 7118 Bertner Ave., Houston, TX 77030
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~2.68 miles west of 77221
  • High-end Convention Center property
  • Check in: 3:00PM
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From$169
Average 3.0 /5 Read Reviews Call BookMore Details
Days Inn & Suites by Wyndham Downtown / University of Houston - Houston 6190 Gulf Freeway, Houston, TX 77023
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~2.72 miles east of 77221
  • 3-star Downtown hotel
  • Check-in: 2:00pm
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From$55
Average 3.0 /5 Guest Reviews Call BookMore Details
Lexington Hotel Houston Medical Center - Houston 1025 Swanson St., Houston, TX 77030
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~2.78 miles west of 77221
  • Economy Downtown property
  • Gym is available on property
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From$60
Average 3.5 /5 Latest Reviews Call BookMore Details
Hyatt Place 7329a Fannin St., Houston, TX 77030
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~2.78 miles west of 77221
  • Midscale property
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From$80
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Hyatt Place Hyatt House Houston Medical Center 7329 Fannin St., Houston, TX 77030
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~2.78 miles west of 77221
  • Three Star Suburban property
  • 3 meeting rooms in hotel
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From$99
Average 3.0 /5 Reviews Call BookMore Details
Houston Marriott Medical Center/Museum District in Houston 6580 Fannin St., Houston, TX 77030
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~2.80 miles west of 77221
  • High-end Downtown hotel
  • Hotel has 386 rooms
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From$75
Very Good 4.5 /5 Read Reviews Call BookMore Details
The Westin Hou Medical Center : 1709 Dryden Rd. 1709 Dryden Rd., Houston, TX 77030
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~2.81 miles west of 77221
  • Mid-scale hotel
  • Check in: 15:00
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From$90
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Sonder at Mid Main 3550 Main St., Houston, TX 77002
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~2.86 miles northwest of 77221
  • Three Star Downtown property
  • Hotel has 4 floors
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From$75
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Hampton Inn & Suites Houston Medical Center Nrg Park 1715 Old Spanish Trail, Houston, TX 77054
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~2.91 miles west of 77221
  • 3 star Convention Center property
  • 3 meeting rooms in property
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From$69
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Houston Medical Center Hotel - Houston 6700 Main St., Houston, TX 77030
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~2.94 miles west of 77221
  • Three Star Downtown property
  • 6 floors in property
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From$115
Average 3.5 /5 Latest Reviews Call BookMore Details
InterContinental Houston by IHG 6750 Main St., Houston, TX 77030
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~2.98 miles west of 77221
  • High end Downtown property
  • 354 rooms in property
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From$75
Average 3.0 /5 Recent Reviews Call BookMore Details
Doubletree by Hilton Houston Medical Center Hotel & Suites in Houston 6800 Main St., Houston, TX 77030
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~3.01 miles west of 77221
  • 4-star Downtown property
  • Fitness + Health Center
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From$125
Average 3.0 /5 Recent Reviews Call BookMore Details
Extended Stay America - Houston - Med Ctr-NRG Park-Fannin 7979 Fannin, Houston, TX 77054
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~3.01 miles west of 77221
  • Low priced Convention Center property
  • 3 floors in property
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From$49
Poor 2.5 /5 Guest Reviews Call BookMore Details
Holiday Inn Express Houston Downtown in Houston 1810 Bell St., Houston, TX 77003
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~3.10 miles north of 77221
  • Midscale Downtown property
  • 22 suites in hotel
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From$80
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Wanderstay Boutique Hotel : 520 Sampson St. 520 Sampson St., Houston, TX 77003
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~3.15 miles north of 77221
  • 4 star property
  • Check in time: 2:00PM CST
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From$125
Average 3.0 /5 Recent Reviews Call BookMore Details
SpringHill Suites Houston Medical Center/NRG Park - Houston 1400 Old Spanish Trl, Houston, TX 77054
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~3.32 miles west of 77221
  • Three Star Downtown property
  • Comp. Breakfast
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From$80
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Whyhotel Houston Downtown - Houston 1515 Austin St., Houston, TX 77002
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~3.33 miles north of 77221
  • Midscale property
  • 103 rooms in hotel
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From$90
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Athens Hotel Suites 1308 Clay St., Houston, TX 77002
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~3.39 miles north of 77221
  • 3-star Downtown hotel
  • Free breakfast
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From$89
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La Colombe D Or Hotel in Houston 3410 Montrose Blvd., Houston, TX 77006
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~3.40 miles northwest of 77221
  • 3 star hotel
  • 2 floors in property
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From$90
Average 3.0 /5 Review Score Call BookMore Details
Hilton Americas Houston 1600 Lamar St., Houston, TX 77010
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~3.40 miles north of 77221
  • Four star Downtown hotel
  • Check in: 3:00 PM
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From$101
Very Good 4.5 /5 Read Reviews Call BookMore Details
Hotel Saint Augustine in Houston 4110 Loretto Dr., Houston, TX 77006
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~3.41 miles northwest of 77221
  • Expensive Downtown hotel
  • Check in time: 3:00 PM
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From$401
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Embassy Suites Houston Downtown 1515 Dallas, Houston, TX 77010
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~3.42 miles north of 77221
  • Three Star Downtown property
  • 262 suites in property
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From$135
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Sonder Midtown - Houston 306 Mcgowen St., Houston, TX 77006
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~3.44 miles northwest of 77221
  • Three Star Downtown property
  • 11 rooms in hotel
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From$75
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Holiday Inn Houston Downtown by IHG 1616 Main St., Houston, TX 77002
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~3.46 miles north of 77221
  • Midscale Downtown hotel
  • Fitness center on property
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From$79
Poor 2.0 /5 Reviews Call BookMore Details
Marriott Marquis Houston 1777 Walker St., Houston, TX 77010
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~3.46 miles north of 77221
  • Four star property
  • Check in: 16:00
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From$375
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Courtyard by Marriott Houston Medical Center/NRG Park : Houston Medical Center 7702 Main St. Houston Medical Center 7702 Main St., Houston, TX 77030
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~3.47 miles west of 77221
  • Midscale Suburban hotel
  • Fitness + Health Center
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From$69
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Sonder Lofts at Ballpark - Houston 610 St. Emanuel St. Houston Tx 77003, Houston, TX 77003
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~3.47 miles north of 77221
  • Mid-scale Downtown property
  • Hotel has 22 suites
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From$100
Average 3.0 /5 Reviews Call BookMore Details
The Reside - Houston 7755 South Main St., Houston, TX 77054
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~3.50 miles west of 77221
  • 3 star Downtown property
  • 36 sleeping rooms in hotel
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From$55
Very Good 4.0 /5 Review Score Call BookMore Details
Holiday Inn Houston S - Nrg Area - Medical Center by IHG 8111 Kirby Dr., Houston, TX 77054
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~3.50 miles west of 77221
  • Affordable Suburban property
  • Check-in time: 3:00 PM
More Photos Photo of Holiday Inn Houston S - Nrg Area - Medical Center by IHG
From$126
Average 3.5 /5 Review Score Call BookMore Details
Four Seasons Hotel Houston 1300 Lamar St., Houston, TX 77010
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~3.51 miles north of 77221
  • Luxury 5-star Downtown hotel
  • Airport shuttle available
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From$275
Very Good 4.0 /5 Review Score Call BookMore Details
Extended Stay America Suites Houston Med Ctr NRG Park Kirby : 1303 La Concha Ln 1303 La Concha Ln, Houston, TX 77054
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~3.52 miles west of 77221
  • Inexpensive Convention Center property
  • Fitness + Health Center
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From$41
Average 3.0 /5 Read Reviews Call BookMore Details
Courtyard Houston Medical Center / Nrg Park 7702 Main St., Houston, TX 77030
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~3.55 miles west of 77221
  • Affordable Downtown property
  • 6 suites in property
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From$80
Average 3.0 /5 Recent Reviews Call BookMore Details
Bayou City Event Center : 9401 Knight Rd. 9401 Knight Rd., Houston, TX 77045
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~3.55 miles southwest of 77221
  • Low-priced property
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From$60
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Residence Inn Houston Medical Center / Nrg Park : 7807 Kirby Dr. 7807 Kirby Dr., Houston, TX 77030
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~3.56 miles west of 77221
  • Affordable Downtown hotel
  • 182 suites in hotel
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From$109
Very Good 4.0 /5 Reviews Call BookMore Details

Next: Show All Available 77221 Hotels with Pricing

Graph: Upcoming 20 Days of Houston Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Houston, TX discounts available. The chart reflects the cheapest Houston hotel for each day and each star rating category.

FAQs about hotels near 77221

What are the most favored hotels near 77221?

Home2 Suites, Hotel Zaza Houston Museum District and Houston Marriott Medical Center are the best rated hotels based on customer reviews in the last 365 days.

What are the most luxurious hotels near 77221?

Four Seasons Hotel Houston, Cliù Luxury Boutique Condo Hotel and Hilton University of Houston are the top 3 luxury hotels near 77221.

What hotels are closest to the area of 77221?

Cliù Luxury Boutique Condo Hotel, Extended Stay America Suites Houston Med Ctr Greenway Plaza, and Summit Inn - Houston Medical Center are the properties closest to 77221.

How much does a cheap hotel near 77221 cost per night?

In the last year, a 2 star hotel near 77221 can be as cheap as $63.37 per night. (based on HotelPlanner prices)

How much does a 3 star hotel near 77221 cost per night?

In the last year, the average 3 star hotel near 77221 has been $85.49 per night. (based on HotelPlanner prices)

How much does a 4-5 star hotel near 77221 cost?

In the last year, the average 4 star hotel near 77221 has been $111.54 per night. (based on HotelPlanner prices)

What are the best independent hotels near 77221?

Hotel Zaza Houston Museum District, Scott Inn Suites Downtown Houston and Blossom Houston Medical Center are the best rated independent hotels (not part of a big brand).

What are the most popular Marriott hotels near 77221?

Houston Marriott Medical Center, The Westin Hou Medical Center and Marriott Marquis Houston are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the best IHG hotels near 77221?

Holiday Inn Houston S - Nrg Area - Medical Center by IHG, Holiday Inn Houston Downtown by IHG and InterContinental Houston by IHG are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

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