Hotels in 77221 - Houston TX

Only hotels in 77221 zip code are listed below. Search for cheap and discount hotel rates in Houston, TX for your upcoming leisure or conference / group travel. We list the best 77221 hotels and motels so you can review the Houston hotel list below to find the perfect lodging. Hotels in Harris county and area code 713 are also listed.

Star Rating
Hotel Name
Price Range (USD)to
Amenities

77221 Hotels/Motels & Accommodations

Extended Stay America Houston Greenway Plaza
+1-888-690-5247

How should we direct your call?

New Reservations: +1-888-690-5247 Group Sales: +1-888-494-8863 Front Desk: 7135210060
2330 Southwest Frwy, Houston, TX 77098 ~1.17 miles west of 77221
  • Cheap Downtown hotel
  • Check in time: 3:00 PM
  • No Wifi
  • Staff was very friendly
More PhotosPhoto of Extended Stay America Houston Greenway Plaza
From$61
Average 3.5 /5Review Score CallBookMore Details
Econo Lodge - Houston
+1-888-305-3366

How should we direct your call?

New Reservations: +1-888-305-3366 Group Sales: +1-888-494-8863
3138 Old Spanish Trail, Houston, TX 77054 ~1.37 miles west of 77221
  • Cheap property
More Photos hotel room
From$60
Not Good 1.5 /5Read Reviews CallBookMore Details
Hilton University of Houston
+1-800-881-1523

How should we direct your call?

New Reservations: +1-800-881-1523 Group Sales: +1-888-494-8863 Front Desk: 18325316300
4800 Calhoun Rd., Houston, TX 77004 ~1.39 miles northeast of 77221
  • 4 star Downtown hotel
  • 8 floors in hotel
  • Good for sightseeing and close to the city center
  • Rooms are ok
More Photos Image of Hilton University of Houston
From$91
Very Good 4.0 /5Read Reviews CallBookMore Details
Mainstay Suites
+1-888-283-3404

How should we direct your call?

New Reservations: +1-888-283-3404 Group Sales: +1-888-494-8863
3134 Old Spanish Trail, Houston, TX 77054 ~1.41 miles west of 77221
  • 2-star Convention Center property
  • 89 rooms in hotel
  • Close to university
  • Average parking
More Photos Exterior of Mainstay Suites
From$60
Very Good 4.0 /5Guest Reviews CallBookMore Details
Americas Best Value Inn Medical Center Downtown in Houston
+1-866-221-8581

How should we direct your call?

New Reservations: +1-866-221-8581 Group Sales: +1-888-494-8863 Front Desk: 12819744432
2419 Riverside Dr., Houston, TX 77004 ~1.65 miles northwest of 77221
  • Economy hotel
  • Free breakfast
More Photos Exterior of Americas Best Value Inn Medical Center Downtown
From$60
Average 3.0 /5Guest Reviews CallBookMore Details
Best Way Inn Houston Medical Center in Houston
+1-866-429-5787

How should we direct your call?

New Reservations: +1-866-429-5787 Group Sales: +1-888-494-8863 Front Desk: 17137382222
3100 Holmes Rd., Houston, TX 77051 ~2.49 miles southwest of 77221
  • Inexpensive hotel
More Photos Photo of Best Way Inn Houston Medical Center
From$60
Poor 2.5 /5Reviews CallBookMore Details
Extended Stay Deluxe Houston Medical Center
+1-888-690-5281

How should we direct your call?

New Reservations: +1-888-690-5281 Group Sales: +1-888-494-8863
1301 Braeswood Blvd., Houston, TX 77030 ~2.52 miles west of 77221
  • Affordable Convention Center hotel
  • Check-in: 3:00pm
  • Loud music
  • Refrigerator did not work
More Photos hotel room
From$64
Average 3.0 /5Reviews CallBookMore Details
Hotel Zaza Houston
+1-888-690-5247

How should we direct your call?

New Reservations: +1-888-690-5247 Group Sales: +1-888-494-8863 Front Desk: 17135261991
5701 Main St., Houston, TX 77005 ~2.57 miles northwest of 77221
  • Four-star Downtown hotel
  • Fitness + Health Center
  • Great amenities
  • Restaurant staff excellent
More Photos Photo of Hotel Zaza Houston
From$159
Very Good 4.5 /5Guest Reviews CallBookMore Details
Lexington Hotel Houston Medical Center : 1025 Swanson St.
+1-888-305-3366

How should we direct your call?

New Reservations: +1-888-305-3366 Group Sales: +1-888-494-8863 Front Desk: 17137901617
1025 Swanson St., Houston, TX 77030 ~2.78 miles west of 77221
  • Low priced Downtown property
  • Free comp. breakfast
  • Less expensive place to stay
  • Office doesn't open
More Photos Image of Lexington Hotel Houston Medical Center
From$60
Average 3.5 /5Recent Reviews CallBookMore Details
Houston Marriott Medical Center
+1-800-881-1523

How should we direct your call?

New Reservations: +1-800-881-1523 Group Sales: +1-888-494-8863 Front Desk: 17137960080
6580 Fannin St., Houston, TX 77030 ~2.80 miles west of 77221
  • 4 star Downtown property
  • Check-in time: 1pm
More Photos Exterior of Houston Marriott Medical Center
From$75
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Hampton Inn & Suites Medical Center
+1-888-283-3404

How should we direct your call?

New Reservations: +1-888-283-3404 Group Sales: +1-888-494-8863 Front Desk: 17137970040
1715 Old Spanish Trail, Houston, TX 77054 ~2.92 miles west of 77221
  • Mid-scale Convention Center property
  • Fitness center on property
More Photos Photo of Hampton Inn & Suites Medical Center
From$75
Very Good 4.0 /5Recent Reviews CallBookMore Details
Hilton Houston Medical Plaza - Houston
+1-866-221-8581

How should we direct your call?

New Reservations: +1-866-221-8581 Group Sales: +1-888-494-8863 Front Desk: 17133137600
6633 Travis St., Houston, TX 77030 ~2.93 miles west of 77221
  • Three Star Downtown property
  • Hotel has 144 suites
More Photos Image of Hilton Houston Medical Plaza
From$109
Average 3.5 /5Review Score CallBookMore Details
SureStay Plus Hotel by Best Western Houston Medical Center - Houston
+1-866-429-5787

How should we direct your call?

New Reservations: +1-866-429-5787 Group Sales: +1-888-494-8863 Front Desk: 17135222811
6700 South Main St., Houston, TX 77030 ~2.94 miles west of 77221
  • Midscale Downtown property
  • Check-in: 03:00
More Photos Exterior of SureStay Plus Hotel by Best Western Houston Medical Center
From$110
Average 3.5 /5Guest Reviews CallBookMore Details
Robin's Nest Bed & Breakfast Inn : 4104 Greeley St.
+1-888-690-5281

How should we direct your call?

New Reservations: +1-888-690-5281 Group Sales: +1-888-494-8863
4104 Greeley St., Houston, TX 77006 ~2.99 miles northwest of 77221
  • 3-star Downtown property
  • Hotel has 2 floors
More Photos Photo of Robin's Nest Bed & Breakfast Inn
From$195
Very Good 4.5 /5Recent Reviews CallBookMore Details
Wyndham Houston Medical Center
+1-888-690-5247

How should we direct your call?

New Reservations: +1-888-690-5247 Group Sales: +1-888-494-8863 Front Desk: 17135287777
6800 Main St., Houston, TX 77030 ~3.01 miles west of 77221
  • Affordable Downtown property
  • 287 sleeping rooms in hotel
More Photos Photo of Wyndham Houston Medical Center
From$89
Very Good 4.0 /5Read Reviews CallBookMore Details
Extended Houston Med. Center Ngr Pk. Fannin S (Med in Houston
+1-888-305-3366

How should we direct your call?

New Reservations: +1-888-305-3366 Group Sales: +1-888-494-8863 Front Desk: 7137970000
7979 Fannin, Houston, TX 77054 ~3.02 miles west of 77221
  • Inexpensive Convention Center property
  • Hotel has 153 rooms
  • Almost all guests said rooms were small
  • Bathroom could be optimized
More Photos Photo of Extended Houston Med. Center Ngr Pk. Fannin S (Med
From$49
Poor 2.5 /5Reviews CallBookMore Details
Holiday Inn Express Downtown Convention Center in Houston
+1-800-881-1523

How should we direct your call?

New Reservations: +1-800-881-1523 Group Sales: +1-888-494-8863 Front Desk: 17136529400
1810 Bell St., Houston, TX 77003 ~3.11 miles north of 77221
  • 3-star Downtown hotel
  • 112 rooms in hotel
  • Accessible parking
  • The majority of guests thought they were poorly maintained
More Photos hotel room
From$108
Very Good 4.0 /5Hotel Reviews CallBookMore Details
Springhill Suites by Marriott Houston Nrg Park : 1400 Old Spanish Trail
+1-888-283-3404

How should we direct your call?

New Reservations: +1-888-283-3404 Group Sales: +1-888-494-8863 Front Desk: 17137961000
1400 Old Spanish Trail, Houston, TX 77054 ~3.33 miles west of 77221
  • 3 star Downtown property
  • 7 floors in hotel
  • Don't have Internet access
  • Check in were very nice and helpful
More Photos Image of Springhill Suites by Marriott Houston Nrg Park
From$99
Very Good 4.0 /5Hotel Reviews CallBookMore Details
Athens Hotel & Suites : 1308 Clay St.
+1-866-221-8581

How should we direct your call?

New Reservations: +1-866-221-8581 Group Sales: +1-888-494-8863 Front Desk: 17137391960
1308 Clay St., Houston, TX 77002 ~3.39 miles north of 77221
  • Midscale Downtown hotel
  • Gym is available on property
  • Breakfast can be improved
  • Rooms are ok
More Photos Photo of Athens Hotel & Suites
From$89
Average 3.5 /5Guest Reviews CallBookMore Details
La Colombe D Or Hotel
+1-866-429-5787

How should we direct your call?

New Reservations: +1-866-429-5787 Group Sales: +1-888-494-8863 Front Desk: 17135247999
3410 Montrose Blvd., Houston, TX 77006 ~3.41 miles northwest of 77221
  • Affordable property
  • 15 sleeping rooms in hotel
More Photos hotel room
From$90
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Embassy Suites Houston Downtown - Houston
+1-888-690-5281

How should we direct your call?

New Reservations: +1-888-690-5281 Group Sales: +1-888-494-8863 Front Desk: 17137399100
1515 Dallas, Houston, TX 77010 ~3.43 miles north of 77221
  • Three Star Downtown property
  • 5 meeting rooms in hotel
More Photos Image of Embassy Suites Houston Downtown
From$135
Very Good 4.5 /5Read Reviews CallBookMore Details
Holiday Inn Houston Downtown
+1-888-690-5247

How should we direct your call?

New Reservations: +1-888-690-5247 Group Sales: +1-888-494-8863 Front Desk: 17136588888
1616 Main St., Houston, TX 77002 ~3.44 miles north of 77221
  • Midscale Downtown hotel
  • 213 rooms in property
More Photos Image of Holiday Inn Houston Downtown
From$88
Very Good 4.0 /5Latest Reviews CallBookMore Details
Marriott Marquis Houston - Houston
+1-888-305-3366

How should we direct your call?

New Reservations: +1-888-305-3366 Group Sales: +1-888-494-8863 Front Desk: 7136541777
1777 Walker St., Houston, TX 77010 ~3.47 miles north of 77221
  • Four-star hotel
  • Check in time: 16:00
More Photos Photo of Marriott Marquis Houston
From$150
Very Good 4.5 /5Read Reviews CallBookMore Details
The Reside : 7755 South Main St.
+1-800-881-1523

How should we direct your call?

New Reservations: +1-800-881-1523 Group Sales: +1-888-494-8863 Front Desk: 17137919454
7755 South Main St., Houston, TX 77054 ~3.51 miles west of 77221
  • 4-star Downtown hotel
  • 36 rooms in hotel
More Photos Image of The Reside
From$55
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Holiday Inn Houston N R G Park Area in Houston
+1-888-283-3404

How should we direct your call?

New Reservations: +1-888-283-3404 Group Sales: +1-888-494-8863 Front Desk: 17137901900
8111 Kirby Dr., Houston, TX 77054 ~3.51 miles west of 77221
  • Three Star Suburban property
  • Check-in time: 3:00 PM
  • Average comfort
  • Housekeeping can be a problem
More Photos Exterior of Holiday Inn Houston N R G Park Area
From$126
Average 3.5 /5Review Score CallBookMore Details
Extended Stay Deluxe Houston Medical Center La Con
+1-866-221-8581

How should we direct your call?

New Reservations: +1-866-221-8581 Group Sales: +1-888-494-8863 Front Desk: 17139609660
1303 La Concha Ln, Houston, TX 77054 ~3.52 miles west of 77221
  • Economy Convention Center hotel
  • Hotel has 3 floors
  • Rooms are not good
  • Couch dirty
More Photos Exterior of Extended Stay Deluxe Houston Medical Center La Con
From$41
Very Good 4.0 /5Reviews CallBookMore Details
Four Seasons Hotel Houston : 1300 Lamar St.
+1-866-429-5787

How should we direct your call?

New Reservations: +1-866-429-5787 Group Sales: +1-888-494-8863 Front Desk: 17136501300
1300 Lamar St., Houston, TX 77010 ~3.52 miles north of 77221
  • Luxurious Five Star Downtown hotel
  • Fitness + Health Center
  • Delicious food
  • Popular among business travelers
More Photos Image of Four Seasons Hotel Houston
From$150
Very Good 4.5 /5Read Reviews CallBookMore Details
Residence Inn by Marriott Medical Center / Reliant
+1-888-690-5281

How should we direct your call?

New Reservations: +1-888-690-5281 Group Sales: +1-888-494-8863 Front Desk: 17136607993
7710 Main St., Houston, TX 77030 ~3.54 miles west of 77221
  • 3 star Highway property
  • Fitness center on property
  • Room is all right
  • Wonderful sightseeing
More Photos Photo of Residence Inn by Marriott Medical Center / Reliant
From$69
Average 3.5 /5Hotel Reviews CallBookMore Details
Courtyard by Marriott Houston Medical Center - Houston
+1-888-690-5247

How should we direct your call?

New Reservations: +1-888-690-5247 Group Sales: +1-888-494-8863 Front Desk: 17136684500
Houston Medical Center, Houston, TX 77030 ~3.55 miles west of 77221
  • 3-star Downtown property
  • Gym is available on property
More Photos Image of Courtyard by Marriott Houston Medical Center
From$109
Very Good 4.0 /5Review Score CallBookMore Details
Residence Inn Houston Medical Center
+1-888-305-3366

How should we direct your call?

New Reservations: +1-888-305-3366 Group Sales: +1-888-494-8863 Front Desk: 17136607993
7807 Kirby Dr., Houston, TX 77030 ~3.56 miles west of 77221
  • Four star Convention Center hotel
  • Gym / Fitness Center Available
More Photos hotel room
From$109
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Moody Manor : 7706 Main St.
+1-800-881-1523

How should we direct your call?

New Reservations: +1-800-881-1523 Group Sales: +1-888-494-8863 Front Desk: 17136607993
7706 Main St., Houston, TX 77030 ~3.58 miles west of 77221
  • 3 star Downtown property
  • Hotel has 2 floors
More Photos Exterior of Moody Manor
From$69
Average 3.5 /5Reviews CallBookMore Details
Hampton Inn Houston Downtown - Houston
+1-888-283-3404

How should we direct your call?

New Reservations: +1-888-283-3404 Group Sales: +1-888-494-8863 Front Desk: 17132240011
710 Crawford St., Houston, TX 77002 ~3.58 miles north of 77221
  • Mid-scale Convention Center hotel
  • 14 floors in hotel
More Photos Image of Hampton Inn Houston Downtown
From$89
Very Good 4.5 /5Latest Reviews CallBookMore Details
Oakwood at Midtown Arbor Place
+1-866-221-8581

How should we direct your call?

New Reservations: +1-866-221-8581 Group Sales: +1-888-494-8863 Front Desk: 18003193303
10 Oak Court, Houston, TX 77006 ~3.58 miles north of 77221
  • Three Star hotel
  • Check-in time: 15:30
More Photos hotel room
From$90
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Hotel Alessandra
+1-866-429-5787

How should we direct your call?

New Reservations: +1-866-429-5787 Group Sales: +1-888-494-8863 Front Desk: 17132426017
1070 Dallas St., Houston, TX 77002 ~3.59 miles north of 77221
  • Luxurious Five Star hotel
More Photos Photo of Hotel Alessandra
From$139
Excellent 5.0 /5Reviews CallBookMore Details
Rodeway Inn & Suites Medical Center in Houston
+1-888-690-5281

How should we direct your call?

New Reservations: +1-888-690-5281 Group Sales: +1-888-494-8863
6712 Morningside Dr., Houston, TX 77030 ~3.60 miles west of 77221
  • Low priced Downtown property
  • Check-in time: 11:00
  • Average value
  • The majority of guests thought the air conditioning was adequate
More Photos Image of Rodeway Inn & Suites Medical Center
From$60
Not Good 1.5 /5Read Reviews CallBookMore Details
The Whitehall Houston in Houston
+1-888-690-5247

How should we direct your call?

New Reservations: +1-888-690-5247 Group Sales: +1-888-494-8863 Front Desk: 17137398800
1700 Smith St., Houston, TX 77002 ~3.62 miles north of 77221
  • Expensive Downtown property
  • 13 meeting rooms in property
More Photos Image of The Whitehall Houston
From$109
Very Good 4.5 /5Hotel Reviews CallBookMore Details
Americas Best Value Inn Near Nrg Park / Medical Center
+1-888-305-3366

How should we direct your call?

New Reservations: +1-888-305-3366 Group Sales: +1-888-494-8863 Front Desk: 17136678200
7905 South Main St., Houston, TX 77025 ~3.63 miles west of 77221
  • Two star property
  • 70 rooms in property
More Photos Photo of Americas Best Value Inn Near Nrg Park / Medical Center
From$72
Average 3.0 /5Recent Reviews CallBookMore Details
Residence Inn Houston Downtown : 904 Dallas St.
+1-800-881-1523

How should we direct your call?

New Reservations: +1-800-881-1523 Group Sales: +1-888-494-8863 Front Desk: 18323661000
904 Dallas St., Houston, TX 77002 ~3.64 miles north of 77221
  • 3 star Downtown property
  • Hotel has 10 floors
  • Close to parking areas
  • Every guests reviewed thought rooms were spacious
More Photos Image of Residence Inn Houston Downtown
From$75
Very Good 4.0 /5Latest Reviews CallBookMore Details
Courtyard Houston Downtown - Houston
+1-888-283-3404

How should we direct your call?

New Reservations: +1-888-283-3404 Group Sales: +1-888-494-8863 Front Desk: 8323661600
916 Dallas St., Houston, TX 77002 ~3.64 miles north of 77221
  • Three Star Downtown property
  • 6 suites in property
More Photos Photo of Courtyard Houston Downtown
From$75
Very Good 4.0 /5Hotel Reviews CallBookMore Details
Springhill Suites Houston Downtown / Convention Center
+1-866-221-8581

How should we direct your call?

New Reservations: +1-866-221-8581 Group Sales: +1-888-494-8863 Front Desk: 17136550002
914 Dallas St., Houston, TX 77002 ~3.65 miles north of 77221
  • 3 star property
  • The majority of guests said the reception staff was great
  • The majority of guests said rooms were clean
More Photos Photo of Springhill Suites Houston Downtown / Convention Center
From$64
Very Good 4.0 /5Hotel Reviews CallBookMore Details
The Westin Houston Downtown
+1-866-429-5787

How should we direct your call?

New Reservations: +1-866-429-5787 Group Sales: +1-888-494-8863 Front Desk: 17132281520
1520 Texas Ave., Houston, TX 77002 ~3.71 miles north of 77221
  • Four star Downtown property
  • 4 meeting rooms in property
  • Close to business sites
  • Awesome dinner
More Photos Photo of The Westin Houston Downtown
From$99
Very Good 4.5 /5Read Reviews CallBookMore Details
Hotel Ylem : 8080 South Main
+1-888-690-5281

How should we direct your call?

New Reservations: +1-888-690-5281 Group Sales: +1-888-494-8863 Front Desk: 17136654439
8080 South Main, Houston, TX 77025 ~3.71 miles west of 77221
  • 3 star Downtown property
  • Check-in: 3:00pm
More Photos Exterior of Hotel Ylem
From$80
Average 3.5 /5Read Reviews CallBookMore Details
Aloft Houston Downtown - Houston
+1-888-690-5247

How should we direct your call?

New Reservations: +1-888-690-5247 Group Sales: +1-888-494-8863 Front Desk: 17132250200
820 Fannin St., Houston, TX 77002 ~3.76 miles north of 77221
  • Midscale Downtown hotel
  • 168 rooms in property
More Photos Exterior of Aloft Houston Downtown
From$109
Average 3.5 /5Reviews CallBookMore Details
Hyatt Regency Houston
+1-888-305-3366

How should we direct your call?

New Reservations: +1-888-305-3366 Group Sales: +1-888-494-8863 Front Desk: 17136541234
1200 Louisiana St., Houston, TX 77002 ~3.76 miles north of 77221
  • High end Downtown property
  • Fitness center on property
More Photos Image of Hyatt Regency Houston
From$179
Very Good 4.0 /5Recent Reviews CallBookMore Details
Club Quarters Hotel Houston
+1-800-881-1523

How should we direct your call?

New Reservations: +1-800-881-1523 Group Sales: +1-888-494-8863 Front Desk: 18322144444
720 Fannin St., Houston, TX 77002 ~3.80 miles north of 77221
  • Four star Downtown property
  • Hotel has 3 meeting rooms
More Photos Image of Club Quarters Hotel Houston
From$70
Very Good 4.0 /5Read Reviews CallBookMore Details
JW Marriott Houston Downtown
+1-888-283-3404

How should we direct your call?

New Reservations: +1-888-283-3404 Group Sales: +1-888-494-8863 Front Desk: 17132371111
806 Main, Houston, TX 77002 ~3.82 miles north of 77221
  • Luxurious 5-star Downtown property
  • Hotel has an eco-friendly policy See more
More Photos Exterior of JW Marriott Houston Downtown
From$139
Very Good 4.5 /5Latest Reviews CallBookMore Details
Comfort Suites
+1-866-221-8581

How should we direct your call?

New Reservations: +1-866-221-8581 Group Sales: +1-888-494-8863 Front Desk: 7136681436
1055 Mcnee Rd., Houston, TX 77054 ~3.85 miles west of 77221
  • Affordable Convention Center hotel
  • Check-in time: 12:00
More Photos Image of Comfort Suites
From$65
CallBookMore Details
Magnolia Hotel - Houston
+1-866-429-5787

How should we direct your call?

New Reservations: +1-866-429-5787 Group Sales: +1-888-494-8863 Front Desk: 12816572600
1100 Texas Ave., Houston, TX 77002 ~3.85 miles north of 77221
  • 4 star Downtown hotel
  • Check-in time: 3:00 PM
  • Most guests were happy with the price of the breakfast
  • Good restaurants & bars in the area
More Photos Photo of Magnolia Hotel
From$109
Very Good 4.5 /5Review Score CallBookMore Details
Doubletree by Hilton Houston Downtown : 400 Dallas St.
+1-888-690-5281

How should we direct your call?

New Reservations: +1-888-690-5281 Group Sales: +1-888-494-8863 Front Desk: 17137590202
400 Dallas St., Houston, TX 77002 ~3.86 miles north of 77221
  • 3-star Downtown property
  • Check-in: 3:00pm
  • Moderately clean hotel facilities
  • All guests thought it was a great value
More Photos Image of Doubletree by Hilton Houston Downtown
From$69
Average 3.5 /5Read Reviews CallBookMore Details
The Sam Houston Hotel Curio a Collection by Hilton
+1-888-690-5247

How should we direct your call?

New Reservations: +1-888-690-5247 Group Sales: +1-888-494-8863 Front Desk: 18322008800
1117 Prairie St., Houston, TX 77002 ~3.91 miles north of 77221
  • Four star Downtown property
  • Fitness + Health Center
More Photos Exterior of The Sam Houston Hotel Curio a Collection by Hilton
From$99
Very Good 4.0 /5Recent Reviews CallBookMore Details

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