Hotels in 77221 - Houston TX

Only hotels in 77221 zip code are listed below. Search for cheap and discount hotel rates in Houston, TX for your upcoming leisure or conference / group travel. We list the best 77221 hotels and motels so you can review the Houston hotel list below to find the perfect lodging. Hotels in Harris county and area code 713 are also listed.

Star Rating
Hotel Name
Price Range (USD) to
Amenities
+ More

77221 Hotels/Motels & Accommodations

Cliù Luxury Boutique Condo Hotel - Houston 3144 Southmore Blvd. Unit 10, Houston, TX 77004
Call Us
~1.13 miles northwest of 77221
  • Four star Downtown hotel
  • Hotel has 2 floors
More Photos Image of Cliù Luxury Boutique Condo Hotel
From$120 total
Average 3.0 /5 Latest Reviews Call BookMore Details
Tired of clicking around? Talk to an expert Hotel Planner: (855) 276-7561 or say...
alexa hotel planner skill"Alexa, ask Hotel Planner to make a new reservation in 77221" Get Alexa Skill →
Extended Stay America Suites Houston Med Ctr Greenway Plaza : 2330 Southwest Frwy 2330 Southwest Frwy, Houston, TX 77098
Call Us
~1.16 miles west of 77221
  • Cheap Downtown hotel
  • 122 sleeping rooms in hotel
More Photos Exterior of Extended Stay America Suites Houston Med Ctr Greenway Plaza
From$73 total
Average 3.0 /5 Hotel Reviews Call BookMore Details
Summit Inn - Houston Medical Center 3138 Old Spanish Trail, Houston, TX 77054
Call Us
~1.37 miles west of 77221
  • 2 star property
  • 33 sleeping rooms in hotel
More Photos Exterior of Summit Inn - Houston Medical Center
From$72 total
Average 3.0 /5 Review Score Call BookMore Details
Mainstay Suites Texas Medical Center / Reliant Park 3134 Old Spanish Trail, Houston, TX 77054
Call Us
~1.41 miles west of 77221
  • Two star Convention Center property
  • Fitness + Health Center
More Photos Photo of Mainstay Suites Texas Medical Center / Reliant Park
From$72 total
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Hilton University of Houston in Houston 4800 Calhoun Rd., Houston, TX 77004
Call Us
~1.54 miles northeast of 77221
  • 4 star Downtown hotel
  • 12 suites in hotel
More Photos Photo of Hilton University of Houston
From$150 total
Average 3.0 /5 Recent Reviews Call BookMore Details
Americas Best Value Inn Medical Center Downtown 2419 Riverside Dr., Houston, TX 77004
Call Us
~1.64 miles northwest of 77221
  • Cheap property
  • 40 sleeping rooms in hotel
More Photos Exterior of Americas Best Value Inn Medical Center Downtown
From$72 total
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Home2 Suites 6840 Almeda Rd., Houston, TX 77030
Call Us
~1.81 miles west of 77221
  • Affordable Suburban hotel
  • Hotel has 10 floors
More Photos Image of Home2 Suites
From$118 total
Excellent 5.0 /5 Review Score Call BookMore Details
Hilton Garden Inn : 6840b Almeda Rd. 6840b Almeda Rd., Houston, TX 77030
Call Us
~1.81 miles west of 77221
  • 3-star Suburban property
  • Check-in: 3:00 PM
More Photos Exterior of Hilton Garden Inn
From$130 total
Average 3.0 /5 Review Score Call BookMore Details
Hilton Garden in Houston 6840 B Almeda Rd., Houston, TX 77030
Call Us
~1.82 miles west of 77221
  • Three Star property
More Photos hotel room
From$96 total
Average 3.0 /5 Recent Reviews Call BookMore Details
Medical District in Houston 2700 Old Spanish Trail, Houston, TX 77021
Call Us
~1.92 miles west of 77221
  • High-end property
More Photos hotel room
From$90 total
Average 3.0 /5 Hotel Reviews Call BookMore Details
Sonder The Hampstead - Houston 1508 Blodgett, Houston, TX 77004
Call Us
~2.32 miles northwest of 77221
  • Three Star Downtown property
  • 36 rooms in property
More Photos Photo of Sonder The Hampstead
From$96 total
Average 3.0 /5 Reviews Call BookMore Details
Scott Inn Suites Downtown Houston 1933 Scott St., Houston, TX 77003
Call Us
~2.34 miles north of 77221
  • Midscale property
  • 2 floors in hotel
More Photos hotel room
From$108 total
Very Good 4.0 /5 Reviews Call BookMore Details
Best Way Inn Houston - Medical Center 3100 Holmes Rd., Houston, TX 77051
Call Us
~2.49 miles southwest of 77221
  • Cheap property
  • 42 rooms in property
More Photos Exterior of Best Way Inn Houston - Medical Center
From$72 total
Average 3.0 /5 Recent Reviews Call BookMore Details
More Homes & Apts at Booking.com

Book online or call +1-800-219-2797

Booking for Homes and Apartments
Go to BookingGo to Booking
Extended Stay America Suites Houston Med Ctr Braeswood Bl in Houston 1301 Braeswood Blvd., Houston, TX 77030
Call Us
~2.52 miles west of 77221
  • 3-star Convention Center hotel
  • 3 floors in property
More Photos Exterior of Extended Stay America Suites Houston Med Ctr Braeswood Bl
From$76 total
Average 3.0 /5 Review Score Call BookMore Details
Hotel Zaza Houston Museum District - Houston 5701 Main St., Houston, TX 77005
Call Us
~2.57 miles northwest of 77221
  • Four star Downtown hotel
  • Hotel has 75 suites
More Photos Exterior of Hotel Zaza Houston Museum District
From$190 total
Very Good 4.5 /5 Latest Reviews Call BookMore Details
Need some questions answered? Talk to an expert Hotel Planner: (855) 276-7561 or say...
alexa hotel planner skill"Alexa, ask Hotel Planner to make a new reservation in 77221" Get Alexa Skill →
Blossom Houston Medical Center - Houston 7114 Bertner Ave., Houston, TX 77030
Call Us
~2.68 miles west of 77221
  • Mid-scale hotel
  • Check-in time: 16:00
More Photos hotel room
From$108 total
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Blossom Hotel Houston : 7118 Bertner Ave. 7118 Bertner Ave., Houston, TX 77030
Call Us
~2.68 miles west of 77221
  • Four star Convention Center hotel
  • Hotel has a green policy Read more
More Photos Image of Blossom Hotel Houston
From$202 total
Average 3.0 /5 Review Score Call BookMore Details
Days Inn & Suites by Wyndham Downtown / University of Houston 6190 Gulf Freeway, Houston, TX 77023
Call Us
~2.72 miles east of 77221
  • 3-star Downtown hotel
  • Hotel has 2 floors
More Photos Photo of Days Inn & Suites by Wyndham Downtown / University of Houston
From$66 total
Average 3.0 /5 Hotel Reviews Call BookMore Details
Lexington Hotel Houston Medical Center - Houston 1025 Swanson St., Houston, TX 77030
Call Us
~2.78 miles west of 77221
  • Low priced Downtown hotel
  • Gym is available on property
More Photos Image of Lexington Hotel Houston Medical Center
From$72 total
Average 3.5 /5 Latest Reviews Call BookMore Details
Hyatt Place in Houston 7329a Fannin St., Houston, TX 77030
Call Us
~2.78 miles west of 77221
  • Three Star property
More Photos hotel room
From$96 total
Average 3.0 /5 Reviews Call BookMore Details
Hyatt Place Hyatt House Houston Medical Center 7329 Fannin St., Houston, TX 77030
Call Us
~2.78 miles west of 77221
  • Three Star Suburban hotel
  • Check-in: 3PM
More Photos Exterior of Hyatt Place Hyatt House Houston Medical Center
From$118 total
Average 3.0 /5 Read Reviews Call BookMore Details
Houston Marriott Medical Center/Museum District - Houston 6580 Fannin St., Houston, TX 77030
Call Us
~2.80 miles west of 77221
  • 4 star Downtown property
  • 22 suites in hotel
More Photos Exterior of Houston Marriott Medical Center/Museum District
From$90 total
Very Good 4.5 /5 Read Reviews Call BookMore Details
The Westin Hou Medical Center : 1709 Dryden Rd. 1709 Dryden Rd., Houston, TX 77030
Call Us
~2.81 miles west of 77221
  • Affordable hotel
  • Access to gym on-site
More Photos Photo of The Westin Hou Medical Center
From$108 total
Very Good 4.0 /5 Reviews Call BookMore Details
Sonder at Mid Main in Houston 3550 Main St., Houston, TX 77002
Call Us
~2.86 miles northwest of 77221
  • 3-star Downtown hotel
  • 2 meeting rooms in hotel
More Photos Exterior of Sonder at Mid Main
From$90 total
Average 3.0 /5 Reviews Call BookMore Details
Hampton Inn & Suites Houston Medical Center Nrg Park 1715 Old Spanish Trail, Houston, TX 77054
Call Us
~2.91 miles west of 77221
  • Three Star Convention Center hotel
  • 5 floors in property
More Photos Photo of Hampton Inn & Suites Houston Medical Center Nrg Park
From$82 total
Very Good 4.0 /5 Reviews Call BookMore Details
Houston Medical Center Hotel 6700 Main St., Houston, TX 77030
Call Us
~2.94 miles west of 77221
  • Midscale Downtown hotel
  • 2 meeting rooms in property
More Photos Photo of Houston Medical Center Hotel
From$138 total
Average 3.5 /5 Hotel Reviews Call BookMore Details
InterContinental Houston by IHG : 6750 Main St. 6750 Main St., Houston, TX 77030
Call Us
~2.98 miles west of 77221
  • Expensive Downtown property
  • 37 suites in hotel
More Photos Image of InterContinental Houston by IHG
From$90 total
Average 3.0 /5 Recent Reviews Call BookMore Details
Doubletree by Hilton Houston Medical Center Hotel & Suites 6800 Main St., Houston, TX 77030
Call Us
~3.01 miles west of 77221
  • Four star Downtown property
  • Check in: 3:00PM
More Photos Photo of Doubletree by Hilton Houston Medical Center Hotel & Suites
From$150 total
Average 3.0 /5 Reviews Call BookMore Details
Extended Stay America - Houston - Med Ctr-NRG Park-Fannin : 7979 Fannin 7979 Fannin, Houston, TX 77054
Call Us
~3.01 miles west of 77221
  • Low-priced Convention Center hotel
  • 12 suites in hotel
More Photos Image of Extended Stay America - Houston - Med Ctr-NRG Park-Fannin
From$58 total
Poor 2.5 /5 Recent Reviews Call BookMore Details
Best Western Premier Houston Downtown/Convention Center Hotel in Houston 1810 Bell St., Houston, TX 77003
Call Us
~3.12 miles north of 77221
  • Mid-scale Downtown property
  • Complimentary breakfast is offered
More Photos hotel room
From$96 total
Average 3.0 /5 Review Score Call BookMore Details
Wanderstay Boutique Hotel : 520 Sampson St. 520 Sampson St., Houston, TX 77003
Call Us
~3.15 miles north of 77221
  • Four star hotel
  • Check in time: 2:00PM CST
More Photos Exterior of Wanderstay Boutique Hotel
From$150 total
Average 3.0 /5 Latest Reviews Call BookMore Details
SpringHill Suites Houston Medical Center/NRG Park 1400 Old Spanish Trl, Houston, TX 77054
Call Us
~3.32 miles west of 77221
  • Midscale Downtown hotel
  • Free complimentary breakfast
More Photos Exterior of SpringHill Suites Houston Medical Center/NRG Park
From$96 total
Average 3.0 /5 Recent Reviews Call BookMore Details
Whyhotel Houston Downtown in Houston 1515 Austin St., Houston, TX 77002
Call Us
~3.33 miles north of 77221
  • Mid-scale property
  • 103 rooms in property
More Photos hotel room
From$108 total
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Athens Hotel Suites 1308 Clay St., Houston, TX 77002
Call Us
~3.39 miles north of 77221
  • 3-star Downtown property
  • Hotel has 21 rooms
More Photos Photo of Athens Hotel Suites
From$106 total
Average 3.0 /5 Read Reviews Call BookMore Details
La Colombe D Or Hotel 3410 Montrose Blvd., Houston, TX 77006
Call Us
~3.40 miles northwest of 77221
  • Midscale property
  • Check-in: 16:00
More Photos hotel room
From$108 total
Average 3.0 /5 Read Reviews Call BookMore Details
Hilton Americas Houston 1600 Lamar St., Houston, TX 77010
Call Us
~3.40 miles north of 77221
  • 4 star Downtown property
  • 24 floors in property
More Photos Image of Hilton Americas Houston
From$121 total
Very Good 4.5 /5 Reviews Call BookMore Details
Hotel Saint Augustine : 4110 Loretto Dr. 4110 Loretto Dr., Houston, TX 77006
Call Us
~3.41 miles northwest of 77221
  • Four star Downtown property
  • 71 sleeping rooms in hotel
More Photos Exterior of Hotel Saint Augustine
From$481 total
Average 3.0 /5 Guest Reviews Call BookMore Details
Embassy Suites Houston Downtown : 1515 Dallas St. 1515 Dallas St., Houston, TX 77002
Call Us
~3.42 miles north of 77221
  • 3 star Downtown property
  • 5 conference rooms in property
More Photos hotel room
From$238 total
Average 3.0 /5 Guest Reviews Call BookMore Details
Embassy Suites Houston Downtown : 1515 Dallas 1515 Dallas, Houston, TX 77010
Call Us
~3.42 miles north of 77221
  • Affordable Downtown property
  • 262 suites in property
More Photos Photo of Embassy Suites Houston Downtown
From$162 total
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Sonder Midtown 306 Mcgowen St., Houston, TX 77006
Call Us
~3.44 miles northwest of 77221
  • Mid-scale Downtown property
  • 11 rooms in property
More Photos Photo of Sonder Midtown
From$90 total
Average 3.0 /5 Review Score Call BookMore Details
Holiday Inn Houston Downtown by IHG - Houston 1616 Main St., Houston, TX 77002
Call Us
~3.46 miles north of 77221
  • Three Star Downtown hotel
  • Fitness / Gym is on-site
More Photos Image of Holiday Inn Houston Downtown by IHG
From$94 total
Poor 2.0 /5 Guest Reviews Call BookMore Details
Marriott Marquis Houston 1777 Walker St., Houston, TX 77010
Call Us
~3.46 miles north of 77221
  • Four star property
  • Access to gym on-site
More Photos Image of Marriott Marquis Houston
From$450 total
Very Good 4.0 /5 Reviews Call BookMore Details
Courtyard by Marriott Houston Medical Center/NRG Park in Houston Houston Medical Center 7702 Main St., Houston, TX 77030
Call Us
~3.47 miles west of 77221
  • Affordable Suburban property
  • Gym is available on property
More Photos Image of Courtyard by Marriott Houston Medical Center/NRG Park
From$82 total
Very Good 4.0 /5 Review Score Call BookMore Details
Sonder Lofts at Ballpark in Houston 610 St. Emanuel St. Houston Tx 77003, Houston, TX 77003
Call Us
~3.47 miles north of 77221
  • Affordable Downtown hotel
  • Check-in: 4:00 PM
More Photos Photo of Sonder Lofts at Ballpark
From$120 total
Average 3.0 /5 Guest Reviews Call BookMore Details
The Reside 7755 South Main St., Houston, TX 77054
Call Us
~3.50 miles west of 77221
  • Midscale Downtown hotel
  • Check-in: 2:00PM
More Photos Exterior of The Reside
From$66 total
Very Good 4.0 /5 Reviews Call BookMore Details
Holiday Inn Houston S - Nrg Area - Medical Center by IHG 8111 Kirby Dr., Houston, TX 77054
Call Us
~3.50 miles west of 77221
  • Three Star Suburban hotel
  • Hotel has 11 floors
More Photos Exterior of Holiday Inn Houston S - Nrg Area - Medical Center by IHG
From$151 total
Average 3.5 /5 Review Score Call BookMore Details
Four Seasons Hotel Houston in Houston 1300 Lamar St., Houston, TX 77010
Call Us
~3.51 miles north of 77221
  • Luxurious 5-star Downtown property
  • Gym is available on property
More Photos Image of Four Seasons Hotel Houston
From$330 total
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Extended Stay America Suites Houston Med Ctr NRG Park Kirby 1303 La Concha Ln, Houston, TX 77054
Call Us
~3.52 miles west of 77221
  • Cheap Convention Center property
  • Hotel has 3 floors
More Photos Exterior of Extended Stay America Suites Houston Med Ctr NRG Park Kirby
From$49 total
Average 3.0 /5 Reviews Call BookMore Details
Courtyard Houston Medical Center / Nrg Park 7702 Main St., Houston, TX 77030
Call Us
~3.55 miles west of 77221
  • 3-star Downtown property
  • Hotel has 6 suites
More Photos Exterior of Courtyard Houston Medical Center / Nrg Park
From$96 total
Average 3.0 /5 Hotel Reviews Call BookMore Details
Bayou City Event Center 9401 Knight Rd., Houston, TX 77045
Call Us
~3.55 miles southwest of 77221
  • Economical property
More Photos hotel room
From$72 total
Average 3.0 /5 Hotel Reviews Call BookMore Details

Next: Show All Available 77221 Hotels with Pricing

Graph: Upcoming 20 Days of Houston Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Houston, TX discounts available. The chart reflects the cheapest Houston hotel for each day and each star rating category.

FAQs about hotels near 77221

What are the most favored hotels near 77221?

Home2 Suites, Hotel Zaza Houston Museum District and Houston Marriott Medical Center are the best rated hotels based on customer reviews in the last 365 days.

What are the most luxurious hotels near 77221?

Four Seasons Hotel Houston, Cliù Luxury Boutique Condo Hotel and Hilton University of Houston are the top 3 luxury hotels near 77221.

What hotels are closest to the area of 77221?

Cliù Luxury Boutique Condo Hotel, Extended Stay America Suites Houston Med Ctr Greenway Plaza, and Summit Inn - Houston Medical Center are the properties closest to 77221.

How much does a cheap hotel near 77221 cost per night?

In the last year, a 2 star hotel near 77221 can be as cheap as $63.37 per night. (based on HotelPlanner prices)

How much does a 3 star hotel near 77221 cost per night?

In the last year, the average 3 star hotel near 77221 has been $85.49 per night. (based on HotelPlanner prices)

How much does a 4-5 star hotel near 77221 cost?

In the last year, the average 4 star hotel near 77221 has been $111.54 per night. (based on HotelPlanner prices)

What are the best independent hotels near 77221?

Hotel Zaza Houston Museum District, Scott Inn Suites Downtown Houston and Blossom Houston Medical Center are the best rated independent hotels (not part of a big brand).

What are the most popular Marriott hotels near 77221?

Houston Marriott Medical Center, The Westin Hou Medical Center and Marriott Marquis Houston are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the best IHG hotels near 77221?

Holiday Inn Houston S - Nrg Area - Medical Center by IHG, Holiday Inn Houston Downtown by IHG and InterContinental Houston by IHG are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

Back to Top