Hotels in 77221 - Houston TX

Only hotels in 77221 zip code are listed below. Search for cheap and discount hotel rates in Houston, TX for your upcoming leisure or conference / group travel. We list the best 77221 hotels and motels so you can review the Houston hotel list below to find the perfect lodging. Hotels in Harris county and area code 713 are also listed.

Star Rating
Hotel Name
Price Range (USD) to
Amenities
+ More

77221 Hotels & Accommodations

Cliù Luxury Boutique Condo Hotel : 3144 Southmore Blvd. Unit 10 3144 Southmore Blvd. Unit 10, Houston, TX 77004
Call Us
~1.13 miles northwest of 77221
  • Expensive Downtown hotel
  • 8 suites in hotel
More Photos Photo of Cliù Luxury Boutique Condo Hotel
From$100
Average 3.0 /5 Hotel Reviews Call BookMore Details
Tired of clicking around? Talk to an expert Hotel Planner: (855) 276-7561 or say...
alexa hotel planner skill"Alexa, ask Hotel Planner to make a new reservation in 77221" Get Alexa Skill →
Extended Stay America Suites Houston Med Ctr Greenway Plaza - Houston 2330 Southwest Frwy, Houston, TX 77098
Call Us
~1.16 miles west of 77221
  • Low-priced Downtown property
  • 3 floors in hotel
More Photos Image of Extended Stay America Suites Houston Med Ctr Greenway Plaza
From$61
Average 3.0 /5 Recent Reviews Call BookMore Details
Summit Inn - Houston Medical Center - Houston 3138 Old Spanish Trail, Houston, TX 77054
Call Us
~1.37 miles west of 77221
  • Low Cost property
  • Check-in time: 11:00
More Photos Image of Summit Inn - Houston Medical Center
From$60
Average 3.0 /5 Review Score Call BookMore Details
Mainstay Suites Texas Medical Center / Reliant Park - Houston 3134 Old Spanish Trail, Houston, TX 77054
Call Us
~1.41 miles west of 77221
  • Low-priced Convention Center property
  • Access to gym on-site
More Photos Exterior of Mainstay Suites Texas Medical Center / Reliant Park
From$60
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Hilton University of Houston 4800 Calhoun Rd., Houston, TX 77004
Call Us
~1.54 miles northeast of 77221
  • Expensive Downtown hotel
  • 8 floors in property
More Photos Image of Hilton University of Houston
From$125
Average 3.0 /5 Guest Reviews Call BookMore Details
Americas Best Value Inn Medical Center Downtown - Houston 2419 Riverside Dr., Houston, TX 77004
Call Us
~1.64 miles northwest of 77221
  • 2 star hotel
  • 2 floors in property
More Photos Image of Americas Best Value Inn Medical Center Downtown
From$60
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Home2 Suites - Houston 6840 Almeda Rd., Houston, TX 77030
Call Us
~1.81 miles west of 77221
  • Affordable Suburban property
  • Hotel has 143 rooms
More Photos Exterior of Home2 Suites
From$99
Excellent 5.0 /5 Hotel Reviews Call BookMore Details
Hilton Garden Inn 6840b Almeda Rd., Houston, TX 77030
Call Us
~1.81 miles west of 77221
  • 3 star Suburban hotel
  • Check-in time: 3:00 PM
More Photos Photo of Hilton Garden Inn
From$109
Average 3.0 /5 Review Score Call BookMore Details
Hilton Garden 6840 B Almeda Rd., Houston, TX 77030
Call Us
~1.82 miles west of 77221
  • Mid-scale property
More Photos hotel room
From$80
Average 3.0 /5 Recent Reviews Call BookMore Details
Medical District 2700 Old Spanish Trail, Houston, TX 77021
Call Us
~1.92 miles west of 77221
  • 4 star hotel
More Photos hotel room
From$75
Average 3.0 /5 Latest Reviews Call BookMore Details
Sonder The Hampstead 1508 Blodgett, Houston, TX 77004
Call Us
~2.32 miles northwest of 77221
  • 3 star Downtown property
  • Hotel has 36 suites
More Photos Exterior of Sonder The Hampstead
From$80
Average 3.0 /5 Recent Reviews Call BookMore Details
Scott Inn Suites Downtown Houston : 1933 Scott St. 1933 Scott St., Houston, TX 77003
Call Us
~2.34 miles north of 77221
  • Midscale hotel
  • Check-in time: 15:00
More Photos hotel room
From$90
Very Good 4.0 /5 Read Reviews Call BookMore Details
Best Way Inn Houston - Medical Center : 3100 Holmes Rd. 3100 Holmes Rd., Houston, TX 77051
Call Us
~2.49 miles southwest of 77221
  • 2-star hotel
  • 42 sleeping rooms in hotel
More Photos Photo of Best Way Inn Houston - Medical Center
From$60
Average 3.0 /5 Reviews Call BookMore Details
More Homes & Apts at Booking.com

Book online or call +1-800-219-2797

Booking for Homes and Apartments
Go to BookingGo to Booking
Extended Stay America Suites Houston Med Ctr Braeswood Bl 1301 Braeswood Blvd., Houston, TX 77030
Call Us
~2.52 miles west of 77221
  • 3 star Convention Center hotel
  • 4 suites in property
More Photos Image of Extended Stay America Suites Houston Med Ctr Braeswood Bl
From$64
Average 3.0 /5 Latest Reviews Call BookMore Details
Hotel Zaza Houston Museum District : 5701 Main St. 5701 Main St., Houston, TX 77005
Call Us
~2.57 miles northwest of 77221
  • 4 star Downtown property
  • Fitness / Gym is on-site
More Photos Photo of Hotel Zaza Houston Museum District
From$159
Very Good 4.5 /5 Review Score Call BookMore Details
Need some questions answered? Talk to an expert Hotel Planner: (855) 276-7561 or say...
alexa hotel planner skill"Alexa, ask Hotel Planner to make a new reservation in 77221" Get Alexa Skill →
Blossom Houston Medical Center in Houston 7114 Bertner Ave., Houston, TX 77030
Call Us
~2.68 miles west of 77221
  • 3-star property
  • 230 rooms in hotel
More Photos hotel room
From$90
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Blossom Hotel Houston 7118 Bertner Ave., Houston, TX 77030
Call Us
~2.68 miles west of 77221
  • Four-star Convention Center property
  • Hotel has an eco-friendly policy Read more
More Photos Photo of Blossom Hotel Houston
From$169
Average 3.0 /5 Guest Reviews Call BookMore Details
Days Inn & Suites by Wyndham Downtown / University of Houston 6190 Gulf Freeway, Houston, TX 77023
Call Us
~2.72 miles east of 77221
  • 3-star Downtown hotel
  • Hotel has 2 floors
More Photos Image of Days Inn & Suites by Wyndham Downtown / University of Houston
From$55
Average 3.0 /5 Review Score Call BookMore Details
Lexington Hotel Houston Medical Center 1025 Swanson St., Houston, TX 77030
Call Us
~2.78 miles west of 77221
  • Inexpensive Downtown property
  • Free complimentary breakfast
More Photos Image of Lexington Hotel Houston Medical Center
From$60
Average 3.5 /5 Hotel Reviews Call BookMore Details
Hyatt Place 7329a Fannin St., Houston, TX 77030
Call Us
~2.78 miles west of 77221
  • 3-star property
More Photos hotel room
From$80
Average 3.0 /5 Guest Reviews Call BookMore Details
Hyatt Place Hyatt House Houston Medical Center - Houston 7329 Fannin St., Houston, TX 77030
Call Us
~2.78 miles west of 77221
  • Midscale Suburban hotel
  • Hotel has 129 suites
More Photos Image of Hyatt Place Hyatt House Houston Medical Center
From$99
Average 3.0 /5 Hotel Reviews Call BookMore Details
Houston Marriott Medical Center/Museum District - Houston 6580 Fannin St., Houston, TX 77030
Call Us
~2.80 miles west of 77221
  • 4 star Downtown property
  • Check-in time: 1pm
More Photos Exterior of Houston Marriott Medical Center/Museum District
From$75
Very Good 4.5 /5 Recent Reviews Call BookMore Details
The Westin Hou Medical Center 1709 Dryden Rd., Houston, TX 77030
Call Us
~2.81 miles west of 77221
  • 3 star hotel
  • Access to gym on-site
More Photos Image of The Westin Hou Medical Center
From$90
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Sonder at Mid Main 3550 Main St., Houston, TX 77002
Call Us
~2.86 miles northwest of 77221
  • 3 star Downtown hotel
  • Hotel has 12 suites
More Photos Exterior of Sonder at Mid Main
From$75
Average 3.0 /5 Recent Reviews Call BookMore Details
Hampton Inn & Suites Houston Medical Center Nrg Park 1715 Old Spanish Trail, Houston, TX 77054
Call Us
~2.91 miles west of 77221
  • 3 star Convention Center hotel
  • Hotel has 5 floors
More Photos Image of Hampton Inn & Suites Houston Medical Center Nrg Park
From$69
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Houston Medical Center Hotel : 6700 Main St. 6700 Main St., Houston, TX 77030
Call Us
~2.94 miles west of 77221
  • Three Star Downtown hotel
  • Check in: 03:00
More Photos Image of Houston Medical Center Hotel
From$115
Average 3.5 /5 Recent Reviews Call BookMore Details
InterContinental Houston by IHG : 6750 Main St. 6750 Main St., Houston, TX 77030
Call Us
~2.98 miles west of 77221
  • 4-star Downtown hotel
  • 21 floors in hotel
More Photos Photo of InterContinental Houston by IHG
From$75
Average 3.0 /5 Guest Reviews Call BookMore Details
Doubletree by Hilton Houston Medical Center Hotel & Suites - Houston 6800 Main St., Houston, TX 77030
Call Us
~3.01 miles west of 77221
  • Four star Downtown hotel
  • Shuttle to airport available
More Photos Photo of Doubletree by Hilton Houston Medical Center Hotel & Suites
From$125
Average 3.0 /5 Latest Reviews Call BookMore Details
Extended Stay America - Houston - Med Ctr-NRG Park-Fannin 7979 Fannin, Houston, TX 77054
Call Us
~3.01 miles west of 77221
  • Low-priced Convention Center property
  • Check in time: 3pm
More Photos Image of Extended Stay America - Houston - Med Ctr-NRG Park-Fannin
From$49
Poor 2.5 /5 Recent Reviews Call BookMore Details
Holiday Inn Express Houston Downtown in Houston 1810 Bell St., Houston, TX 77003
Call Us
~3.10 miles north of 77221
  • Midscale Downtown property
  • Check in: 3:00pm
More Photos hotel room
From$80
Average 3.0 /5 Hotel Reviews Call BookMore Details
Wanderstay Boutique Hotel - Houston 520 Sampson St., Houston, TX 77003
Call Us
~3.15 miles north of 77221
  • High-end hotel
  • Check in: 2:00PM CST
More Photos Image of Wanderstay Boutique Hotel
From$125
Average 3.0 /5 Guest Reviews Call BookMore Details
SpringHill Suites Houston Medical Center/NRG Park 1400 Old Spanish Trl, Houston, TX 77054
Call Us
~3.32 miles west of 77221
  • 3-star Downtown hotel
  • 190 suites in property
More Photos Image of SpringHill Suites Houston Medical Center/NRG Park
From$80
Average 3.0 /5 Reviews Call BookMore Details
Whyhotel Houston Downtown 1515 Austin St., Houston, TX 77002
Call Us
~3.33 miles north of 77221
  • Three Star hotel
  • 103 rooms in hotel
More Photos hotel room
From$90
Very Good 4.0 /5 Read Reviews Call BookMore Details
Athens Hotel Suites : 1308 Clay St. 1308 Clay St., Houston, TX 77002
Call Us
~3.39 miles north of 77221
  • 3-star Downtown hotel
  • Hotel has an eco-friendly policy Read more
More Photos Image of Athens Hotel Suites
From$89
Average 3.0 /5 Reviews Call BookMore Details
La Colombe D Or Hotel - Houston 3410 Montrose Blvd., Houston, TX 77006
Call Us
~3.40 miles northwest of 77221
  • Three Star hotel
  • 15 rooms in property
More Photos hotel room
From$90
Average 3.0 /5 Reviews Call BookMore Details
Hilton Americas Houston - Houston 1600 Lamar St., Houston, TX 77010
Call Us
~3.40 miles north of 77221
  • 4-star Downtown hotel
  • Fitness + Health Center
More Photos Photo of Hilton Americas Houston
From$101
Very Good 4.5 /5 Reviews Call BookMore Details
Hotel Saint Augustine - Houston 4110 Loretto Dr., Houston, TX 77006
Call Us
~3.41 miles northwest of 77221
  • Four star Downtown property
  • 2 floors in property
More Photos Image of Hotel Saint Augustine
From$401
Average 3.0 /5 Recent Reviews Call BookMore Details
Embassy Suites Houston Downtown in Houston 1515 Dallas, Houston, TX 77010
Call Us
~3.42 miles north of 77221
  • 3-star Downtown property
  • 19 floors in property
More Photos Image of Embassy Suites Houston Downtown
From$135
Very Good 4.0 /5 Reviews Call BookMore Details
Sonder Midtown : 306 Mcgowen St. 306 Mcgowen St., Houston, TX 77006
Call Us
~3.44 miles northwest of 77221
  • 3 star Downtown hotel
  • Hotel has 6 floors
More Photos Photo of Sonder Midtown
From$75
Average 3.0 /5 Hotel Reviews Call BookMore Details
Holiday Inn Houston Downtown by IHG 1616 Main St., Houston, TX 77002
Call Us
~3.46 miles north of 77221
  • Midscale Downtown hotel
  • Check-in: 3:00 PM
More Photos Exterior of Holiday Inn Houston Downtown by IHG
From$79
Poor 2.0 /5 Review Score Call BookMore Details
Marriott Marquis Houston 1777 Walker St., Houston, TX 77010
Call Us
~3.46 miles north of 77221
  • High-end hotel
  • Hotel has 40 suites
More Photos Image of Marriott Marquis Houston
From$375
Very Good 4.0 /5 Read Reviews Call BookMore Details
Courtyard by Marriott Houston Medical Center/NRG Park in Houston Houston Medical Center 7702 Main St., Houston, TX 77030
Call Us
~3.47 miles west of 77221
  • Midscale Suburban property
  • Hotel has 8 suites
More Photos Image of Courtyard by Marriott Houston Medical Center/NRG Park
From$69
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Sonder Lofts at Ballpark in Houston 610 St. Emanuel St. Houston Tx 77003, Houston, TX 77003
Call Us
~3.47 miles north of 77221
  • 3 star Downtown property
  • Fitness / Gym is on-site
More Photos Photo of Sonder Lofts at Ballpark
From$100
Average 3.0 /5 Recent Reviews Call BookMore Details
The Reside 7755 South Main St., Houston, TX 77054
Call Us
~3.50 miles west of 77221
  • Midscale Downtown property
  • 36 rooms in property
More Photos Exterior of The Reside
From$55
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Holiday Inn Houston S - Nrg Area - Medical Center by IHG - Houston 8111 Kirby Dr., Houston, TX 77054
Call Us
~3.50 miles west of 77221
  • Three Star Suburban hotel
  • 6 suites in property
More Photos Photo of Holiday Inn Houston S - Nrg Area - Medical Center by IHG
From$126
Average 3.5 /5 Reviews Call BookMore Details
Four Seasons Hotel Houston in Houston 1300 Lamar St., Houston, TX 77010
Call Us
~3.51 miles north of 77221
  • Luxurious 5 Star Downtown hotel
  • 12 meeting rooms in hotel
More Photos Photo of Four Seasons Hotel Houston
From$275
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Extended Stay America Suites Houston Med Ctr NRG Park Kirby - Houston 1303 La Concha Ln, Houston, TX 77054
Call Us
~3.52 miles west of 77221
  • Cheap Convention Center hotel
  • Fitness / Gym is on-site
More Photos Exterior of Extended Stay America Suites Houston Med Ctr NRG Park Kirby
From$41
Average 3.0 /5 Reviews Call BookMore Details
Courtyard Houston Medical Center / Nrg Park 7702 Main St., Houston, TX 77030
Call Us
~3.55 miles west of 77221
  • 3 star Downtown hotel
  • 197 rooms in property
More Photos Image of Courtyard Houston Medical Center / Nrg Park
From$80
Average 3.0 /5 Hotel Reviews Call BookMore Details
Bayou City Event Center - Houston 9401 Knight Rd., Houston, TX 77045
Call Us
~3.55 miles southwest of 77221
  • Economy property
More Photos hotel room
From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
Residence Inn Houston Medical Center / Nrg Park - Houston 7807 Kirby Dr., Houston, TX 77030
Call Us
~3.56 miles west of 77221
  • Midscale Downtown hotel
  • 16 floors in property
More Photos Photo of Residence Inn Houston Medical Center / Nrg Park
From$109
Very Good 4.0 /5 Review Score Call BookMore Details

Next: Show All Available 77221 Hotels with Pricing

Graph: Upcoming 20 Days of Houston Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Houston, TX discounts available. The chart reflects the cheapest Houston hotel for each day and each star rating category.

FAQs about hotels near 77221

What are the most favored hotels near 77221?

Home2 Suites, Hotel Zaza Houston Museum District and Houston Marriott Medical Center are the best rated hotels based on customer reviews in the last 365 days.

What are the most luxurious hotels near 77221?

Four Seasons Hotel Houston, Cliù Luxury Boutique Condo Hotel and Hilton University of Houston are the top 3 luxury hotels near 77221.

What hotels are closest to the area of 77221?

Cliù Luxury Boutique Condo Hotel, Extended Stay America Suites Houston Med Ctr Greenway Plaza, and Summit Inn - Houston Medical Center are the properties closest to 77221.

How much does a cheap hotel near 77221 cost per night?

In the last year, a 2 star hotel near 77221 can be as cheap as $63.37 per night. (based on HotelPlanner prices)

How much does a 3 star hotel near 77221 cost per night?

In the last year, the average 3 star hotel near 77221 has been $85.49 per night. (based on HotelPlanner prices)

How much does a 4-5 star hotel near 77221 cost?

In the last year, the average 4 star hotel near 77221 has been $111.54 per night. (based on HotelPlanner prices)

What are the best independent hotels near 77221?

Hotel Zaza Houston Museum District, Scott Inn Suites Downtown Houston and Blossom Houston Medical Center are the best rated independent hotels (not part of a big brand).

What are the most popular Marriott hotels near 77221?

Houston Marriott Medical Center, The Westin Hou Medical Center and Marriott Marquis Houston are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the best IHG hotels near 77221?

Holiday Inn Houston S - Nrg Area - Medical Center by IHG, Holiday Inn Houston Downtown by IHG and InterContinental Houston by IHG are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

Back to Top