Hotels in 77221 - Houston TX

Only hotels in 77221 zip code are listed below. Search for cheap and discount hotel rates in Houston, TX for your upcoming leisure or conference / group travel. We list the best 77221 hotels and motels so you can review the Houston hotel list below to find the perfect lodging. Hotels in Harris county and area code 713 are also listed.

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77221 Hotels & Accommodations

Cliù Luxury Boutique Condo Hotel - Houston 3144 Southmore Blvd. Unit 10, Houston, TX 77004
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~1.13 miles northwest of 77221
  • 4-star Downtown hotel
  • 2 floors in hotel
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From$100
Average 3.0 /5 Recent Reviews Call BookMore Details
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Extended Stay America Suites Houston Med Ctr Greenway Plaza : 2330 Southwest Frwy 2330 Southwest Frwy, Houston, TX 77098
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~1.16 miles west of 77221
  • 2 star Downtown property
  • Gym / Fitness Center Available
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From$61
Average 3.0 /5 Latest Reviews Call BookMore Details
Summit Inn - Houston Medical Center - Houston 3138 Old Spanish Trail, Houston, TX 77054
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~1.37 miles west of 77221
  • Two-star hotel
  • Hotel has 33 rooms
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From$60
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Mainstay Suites Texas Medical Center / Reliant Park - Houston 3134 Old Spanish Trail, Houston, TX 77054
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~1.41 miles west of 77221
  • Inexpensive Convention Center property
  • 89 rooms in hotel
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From$60
Very Good 4.0 /5 Review Score Call BookMore Details
Hilton University of Houston - Houston 4800 Calhoun Rd., Houston, TX 77004
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~1.54 miles northeast of 77221
  • Four-star Downtown hotel
  • Check in: 3:00PM
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From$125
Average 3.0 /5 Read Reviews Call BookMore Details
Americas Best Value Inn Medical Center Downtown in Houston 2419 Riverside Dr., Houston, TX 77004
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~1.64 miles northwest of 77221
  • 2 star property
  • 40 rooms in property
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From$60
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Home2 Suites 6840 Almeda Rd., Houston, TX 77030
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~1.81 miles west of 77221
  • 3-star Suburban property
  • Hotel has an eco-friendly policy Learn more
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From$99
Excellent 5.0 /5 Hotel Reviews Call BookMore Details
Hilton Garden Inn 6840b Almeda Rd., Houston, TX 77030
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~1.81 miles west of 77221
  • Mid-scale Suburban hotel
  • 10 floors in property
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From$109
Average 3.0 /5 Guest Reviews Call BookMore Details
Hilton Garden - Houston 6840 B Almeda Rd., Houston, TX 77030
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~1.82 miles west of 77221
  • 3-star hotel
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From$80
Average 3.0 /5 Latest Reviews Call BookMore Details
Medical District 2700 Old Spanish Trail, Houston, TX 77021
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~1.92 miles west of 77221
  • 4-star hotel
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From$75
Average 3.0 /5 Reviews Call BookMore Details
Sonder The Hampstead : 1508 Blodgett 1508 Blodgett, Houston, TX 77004
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~2.32 miles northwest of 77221
  • Midscale Downtown hotel
  • 36 suites in hotel
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From$80
Average 3.0 /5 Recent Reviews Call BookMore Details
Scott Inn Suites Downtown Houston in Houston 1933 Scott St., Houston, TX 77003
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~2.34 miles north of 77221
  • Affordable hotel
  • 18 sleeping rooms in hotel
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From$90
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Best Way Inn Houston - Medical Center 3100 Holmes Rd., Houston, TX 77051
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~2.49 miles southwest of 77221
  • 2-star property
  • Check in time: 13:00
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From$60
Average 3.0 /5 Recent Reviews Call BookMore Details
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Extended Stay America Suites Houston Med Ctr Braeswood Bl in Houston 1301 Braeswood Blvd., Houston, TX 77030
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~2.52 miles west of 77221
  • Affordable Convention Center property
  • 130 rooms in property
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From$64
Average 3.0 /5 Review Score Call BookMore Details
Hotel Zaza Houston Museum District 5701 Main St., Houston, TX 77005
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~2.57 miles northwest of 77221
  • 4-star Downtown property
  • Fitness / Gym is on-site
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From$159
Very Good 4.5 /5 Guest Reviews Call BookMore Details
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Blossom Houston Medical Center - Houston 7114 Bertner Ave., Houston, TX 77030
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~2.68 miles west of 77221
  • 3 star property
  • Check in time: 16:00
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From$90
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Blossom Hotel Houston 7118 Bertner Ave., Houston, TX 77030
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~2.68 miles west of 77221
  • High-end Convention Center hotel
  • Hotel has 16 floors
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From$169
Average 3.0 /5 Latest Reviews Call BookMore Details
Days Inn & Suites by Wyndham Downtown / University of Houston - Houston 6190 Gulf Freeway, Houston, TX 77023
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~2.72 miles east of 77221
  • Mid-scale Downtown hotel
  • Fitness / Gym is on-site
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From$55
Average 3.0 /5 Reviews Call BookMore Details
Lexington Hotel Houston Medical Center in Houston 1025 Swanson St., Houston, TX 77030
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~2.78 miles west of 77221
  • Cheap Downtown hotel
  • Free breakfast
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From$60
Average 3.5 /5 Review Score Call BookMore Details
Hyatt Place : 7329a Fannin St. 7329a Fannin St., Houston, TX 77030
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~2.78 miles west of 77221
  • 3-star property
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From$80
Average 3.0 /5 Guest Reviews Call BookMore Details
Hyatt Place Hyatt House Houston Medical Center - Houston 7329 Fannin St., Houston, TX 77030
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~2.78 miles west of 77221
  • Midscale Suburban property
  • 129 suites in hotel
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From$99
Average 3.0 /5 Recent Reviews Call BookMore Details
Houston Marriott Medical Center/Museum District : 6580 Fannin St. 6580 Fannin St., Houston, TX 77030
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~2.80 miles west of 77221
  • High-end Downtown property
  • 22 suites in property
More Photos Photo of Houston Marriott Medical Center/Museum District
From$75
Very Good 4.5 /5 Read Reviews Call BookMore Details
The Westin Hou Medical Center 1709 Dryden Rd., Houston, TX 77030
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~2.81 miles west of 77221
  • Affordable property
  • Hotel has 273 rooms
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From$90
Very Good 4.0 /5 Reviews Call BookMore Details
Sonder at Mid Main 3550 Main St., Houston, TX 77002
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~2.86 miles northwest of 77221
  • 3-star Downtown property
  • 26 sleeping rooms in hotel
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From$75
Average 3.0 /5 Guest Reviews Call BookMore Details
Hampton Inn & Suites Houston Medical Center Nrg Park 1715 Old Spanish Trail, Houston, TX 77054
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~2.91 miles west of 77221
  • Midscale Convention Center property
  • 37 suites in hotel
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From$69
Very Good 4.0 /5 Reviews Call BookMore Details
Houston Medical Center Hotel 6700 Main St., Houston, TX 77030
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~2.94 miles west of 77221
  • Midscale Downtown hotel
  • Free breakfast
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From$115
Average 3.5 /5 Hotel Reviews Call BookMore Details
InterContinental Houston by IHG 6750 Main St., Houston, TX 77030
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~2.98 miles west of 77221
  • Four star Downtown hotel
  • 21 floors in hotel
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From$75
Average 3.0 /5 Latest Reviews Call BookMore Details
Doubletree by Hilton Houston Medical Center Hotel & Suites in Houston 6800 Main St., Houston, TX 77030
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~3.01 miles west of 77221
  • 4-star Downtown property
  • Hotel has 297 rooms
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From$125
Average 3.0 /5 Read Reviews Call BookMore Details
Extended Stay America - Houston - Med Ctr-NRG Park-Fannin 7979 Fannin, Houston, TX 77054
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~3.01 miles west of 77221
  • Two-star Convention Center hotel
  • Hotel has 153 rooms
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From$49
Poor 2.5 /5 Guest Reviews Call BookMore Details
Holiday Inn Express Houston Downtown : 1810 Bell St. 1810 Bell St., Houston, TX 77003
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~3.10 miles north of 77221
  • Mid-scale Downtown property
  • Access to gym on-site
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From$80
Average 3.0 /5 Review Score Call BookMore Details
Wanderstay Boutique Hotel 520 Sampson St., Houston, TX 77003
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~3.15 miles north of 77221
  • Four-star hotel
  • Check in time: 2:00PM CST
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From$125
Average 3.0 /5 Reviews Call BookMore Details
SpringHill Suites Houston Medical Center/NRG Park in Houston 1400 Old Spanish Trl, Houston, TX 77054
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~3.32 miles west of 77221
  • 3 star Downtown hotel
  • 190 suites in hotel
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From$80
Average 3.0 /5 Reviews Call BookMore Details
Whyhotel Houston Downtown : 1515 Austin St. 1515 Austin St., Houston, TX 77002
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~3.33 miles north of 77221
  • 3-star property
  • 103 sleeping rooms in hotel
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From$90
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Athens Hotel Suites : 1308 Clay St. 1308 Clay St., Houston, TX 77002
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~3.39 miles north of 77221
  • Affordable Downtown property
  • Complimentary breakfast is offered
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From$89
Average 3.0 /5 Guest Reviews Call BookMore Details
La Colombe D Or Hotel 3410 Montrose Blvd., Houston, TX 77006
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~3.40 miles northwest of 77221
  • 3 star hotel
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From$90
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Hilton Americas Houston 1600 Lamar St., Houston, TX 77010
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~3.40 miles north of 77221
  • 4 star Downtown hotel
  • 1200 rooms in hotel
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From$101
Very Good 4.5 /5 Read Reviews Call BookMore Details
Hotel Saint Augustine : 4110 Loretto Dr. 4110 Loretto Dr., Houston, TX 77006
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~3.41 miles northwest of 77221
  • Four star Downtown hotel
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From$401
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Embassy Suites Houston Downtown 1515 Dallas, Houston, TX 77010
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~3.42 miles north of 77221
  • Three Star Downtown hotel
  • Check in: 3:00PM
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From$135
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Sonder Midtown 306 Mcgowen St., Houston, TX 77006
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~3.44 miles northwest of 77221
  • 3 star Downtown property
  • Check in: 4:00 PM
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From$75
Average 3.0 /5 Latest Reviews Call BookMore Details
Holiday Inn Houston Downtown by IHG 1616 Main St., Houston, TX 77002
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~3.46 miles north of 77221
  • Three Star Downtown property
  • Hotel has 213 rooms
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From$79
Poor 2.0 /5 Hotel Reviews Call BookMore Details
Marriott Marquis Houston - Houston 1777 Walker St., Houston, TX 77010
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~3.46 miles north of 77221
  • 4-star property
  • 1000 sleeping rooms in hotel
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From$375
Very Good 4.0 /5 Read Reviews Call BookMore Details
Courtyard by Marriott Houston Medical Center/NRG Park Houston Medical Center 7702 Main St., Houston, TX 77030
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~3.47 miles west of 77221
  • Three Star Suburban property
  • Fitness + Health Center
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From$69
Very Good 4.0 /5 Reviews Call BookMore Details
Sonder Lofts at Ballpark 610 St. Emanuel St. Houston Tx 77003, Houston, TX 77003
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~3.47 miles north of 77221
  • 3-star Downtown property
  • Check-in time: 4:00 PM
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From$100
Average 3.0 /5 Review Score Call BookMore Details
The Reside in Houston 7755 South Main St., Houston, TX 77054
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~3.50 miles west of 77221
  • Three Star Downtown property
  • Has environment-friendly policy See more
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From$55
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Holiday Inn Houston S - Nrg Area - Medical Center by IHG : 8111 Kirby Dr. 8111 Kirby Dr., Houston, TX 77054
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~3.50 miles west of 77221
  • Affordable Suburban property
  • Fitness + Health Center
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From$126
Average 3.5 /5 Recent Reviews Call BookMore Details
Four Seasons Hotel Houston 1300 Lamar St., Houston, TX 77010
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~3.51 miles north of 77221
  • Luxury 5-star Downtown property
  • Hotel has 115 suites
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From$275
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Extended Stay America Suites Houston Med Ctr NRG Park Kirby 1303 La Concha Ln, Houston, TX 77054
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~3.52 miles west of 77221
  • Inexpensive Convention Center property
  • Hotel has 45 suites
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From$41
Average 3.0 /5 Hotel Reviews Call BookMore Details
Courtyard Houston Medical Center / Nrg Park in Houston 7702 Main St., Houston, TX 77030
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~3.55 miles west of 77221
  • Midscale Downtown property
  • 3 meeting rooms in property
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From$80
Average 3.0 /5 Review Score Call BookMore Details
Bayou City Event Center : 9401 Knight Rd. 9401 Knight Rd., Houston, TX 77045
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~3.55 miles southwest of 77221
  • 2 star property
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From$60
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Residence Inn Houston Medical Center / Nrg Park in Houston 7807 Kirby Dr., Houston, TX 77030
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~3.56 miles west of 77221
  • Midscale Downtown hotel
  • Free comp. breakfast
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From$109
Very Good 4.0 /5 Review Score Call BookMore Details

Next: Show All Available 77221 Hotels with Pricing

Graph: Upcoming 20 Days of Houston Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Houston, TX discounts available. The chart reflects the cheapest Houston hotel for each day and each star rating category.

FAQs about hotels near 77221

What are the most favored hotels near 77221?

Home2 Suites, Hotel Zaza Houston Museum District and Houston Marriott Medical Center are the best rated hotels based on customer reviews in the last 365 days.

What are the most luxurious hotels near 77221?

Four Seasons Hotel Houston, Cliù Luxury Boutique Condo Hotel and Hilton University of Houston are the top 3 luxury hotels near 77221.

What hotels are closest to the area of 77221?

Cliù Luxury Boutique Condo Hotel, Extended Stay America Suites Houston Med Ctr Greenway Plaza, and Summit Inn - Houston Medical Center are the properties closest to 77221.

How much does a cheap hotel near 77221 cost per night?

In the last year, a 2 star hotel near 77221 can be as cheap as $63.37 per night. (based on HotelPlanner prices)

How much does a 3 star hotel near 77221 cost per night?

In the last year, the average 3 star hotel near 77221 has been $85.49 per night. (based on HotelPlanner prices)

How much does a 4-5 star hotel near 77221 cost?

In the last year, the average 4 star hotel near 77221 has been $111.54 per night. (based on HotelPlanner prices)

What are the best independent hotels near 77221?

Hotel Zaza Houston Museum District, Scott Inn Suites Downtown Houston and Blossom Houston Medical Center are the best rated independent hotels (not part of a big brand).

What are the most popular Marriott hotels near 77221?

Houston Marriott Medical Center, The Westin Hou Medical Center and Marriott Marquis Houston are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the best IHG hotels near 77221?

Holiday Inn Houston S - Nrg Area - Medical Center by IHG, Holiday Inn Houston Downtown by IHG and InterContinental Houston by IHG are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

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