Star Rating
Hotel Name
Price Range (USD) to
Amenities
+ More

77221 Hotels/Accommodations

Cliù Luxury Boutique Condo Hotel in Houston
+1-888-389-4121
3144 Southmore Blvd. Unit 10, Houston, TX 77004 ~1.13 miles northwest of 77221
  • Expensive Downtown hotel
  • 8 suites in hotel
From$100
Average 3.0 /5 Review Score Call BookMore Details
Tired of clicking around? Talk to an expert Hotel Planner: (855) 276-7561 or say...
alexa hotel planner skill"Alexa, ask Hotel Planner to make a new reservation in 77221" Get Alexa Skill →
Extended Stay America Suites Houston Med Ctr Greenway Plaza : 2330 Southwest Frwy
+1-888-675-2083
2330 Southwest Frwy, Houston, TX 77098 ~1.17 miles west of 77221
  • Cheap Downtown property
  • Hotel has 2 suites
From$61
Average 3.0 /5 Recent Reviews Call BookMore Details
Summit Inn
+1-800-716-8490
3138 Old Spanish Trail, Houston, TX 77054 ~1.37 miles west of 77221
  • Low-priced hotel
  • 33 rooms in property
From$60
Average 3.0 /5 Review Score Call BookMore Details
MainStay Suites Texas Medical Center/Reliant Park - Houston
+1-800-805-5223
3134 Old Spanish Trail, Houston, TX 77054 ~1.41 miles west of 77221
  • Two star Convention Center property
  • Fitness center on property
From$60
Very Good 4.0 /5 Read Reviews Call BookMore Details
Hiton University of Houston
+1-888-965-1860
4800 Calhoun Rd., Houston, TX 77004 ~1.54 miles northeast of 77221
  • High-end Downtown property
  • Free comp. breakfast
From$125
Average 3.0 /5 Hotel Reviews Call BookMore Details
Americas Best Value Inn Medical Center Downtown in Houston
+1-888-788-5576
2419 Riverside Dr., Houston, TX 77004 ~1.65 miles northwest of 77221
  • Low-priced property
  • Check in: 15:00
From$60
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Home2 Suites : 6840 Almeda Rd.
+1-888-897-9207
6840 Almeda Rd., Houston, TX 77030 ~1.82 miles west of 77221
  • Mid-scale Suburban property
  • Fitness / Gym is on-site
From$99
Excellent 5.0 /5 Hotel Reviews Call BookMore Details
Hilton Garden Inn : 6840b Almeda Rd.
+1-888-311-4278
6840b Almeda Rd., Houston, TX 77030 ~1.82 miles west of 77221
  • Affordable Suburban hotel
  • Check in time: 3:00 PM
From$109
Average 3.0 /5 Recent Reviews Call BookMore Details
Hilton Garden : 6840 B Almeda Rd.
+1-888-469-4795
6840 B Almeda Rd., Houston, TX 77030 ~1.82 miles west of 77221
  • 3 star hotel
From$80
Average 3.0 /5 Recent Reviews Call BookMore Details
Medical District - Houston
+1-888-734-9421
2700 Old Spanish Trail, Houston, TX 77021 ~1.92 miles west of 77221
  • Expensive hotel
From$75
Average 3.0 /5 Review Score Call BookMore Details
Sonder The Hampstead in Houston
+1-888-841-5292
1508 Blodgett, Houston, TX 77004 ~2.33 miles northwest of 77221
  • Affordable Downtown hotel
  • 36 rooms in property
From$80
Average 3.0 /5 Hotel Reviews Call BookMore Details
Scott Inn Suites Downtown Houston - Houston
+1-888-455-5160
1933 Scott St., Houston, TX 77003 ~2.34 miles north of 77221
  • Mid-scale hotel
  • 18 sleeping rooms in hotel
From$90
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Best Way Inn Houston - Medical Center
+1-888-965-8297
3100 Holmes Rd., Houston, TX 77051 ~2.49 miles southwest of 77221
  • Cheap property
  • Check in time: 13:00
From$60
Average 3.0 /5 Read Reviews Call BookMore Details
Extended Stay America Suites Houston Med Ctr Braeswood Bl - Houston
+1-888-906-6358
1301 Braeswood Blvd., Houston, TX 77030 ~2.52 miles west of 77221
  • Mid-scale Convention Center property
  • 4 suites in hotel
From$64
Average 3.0 /5 Read Reviews Call BookMore Details
Hotel Zaza Houston Museum District - Houston
+1-888-749-6785
5701 Main St., Houston, TX 77005 ~2.57 miles northwest of 77221
  • Expensive Downtown property
  • Hotel has 315 rooms
From$159
Very Good 4.5 /5 Hotel Reviews Call BookMore Details
Need some questions answered? Talk to an expert Hotel Planner: (855) 276-7561 or say...
alexa hotel planner skill"Alexa, ask Hotel Planner to make a new reservation in 77221" Get Alexa Skill →
Blossom Houston Medical Center - Houston
+1-888-878-9982
7114 Bertner Ave., Houston, TX 77030 ~2.68 miles west of 77221
  • Mid-scale property
  • Hotel has 230 rooms
From$90
Very Good 4.0 /5 Review Score Call BookMore Details
Blossom Hotel Houston
+1-888-389-4485
7118 Bertner Ave., Houston, TX 77030 ~2.69 miles west of 77221
  • Four-star Convention Center hotel
  • Check in: 3:00PM
From$130
Average 3.0 /5 Hotel Reviews Call BookMore Details
Days Inn & Suites by Wyndham Downtown / University of Houston - Houston
+1-888-389-4121
6190 Gulf Freeway, Houston, TX 77023 ~2.73 miles east of 77221
  • Affordable Downtown hotel
  • Comp. Breakfast
From$55
Average 3.0 /5 Hotel Reviews Call BookMore Details
Lexington Hotel Houston Medical Center - Houston
+1-888-675-2083
1025 Swanson St., Houston, TX 77030 ~2.78 miles west of 77221
  • Two star Downtown property
  • Free breakfast available
From$60
Average 3.5 /5 Hotel Reviews Call BookMore Details
Hyatt Place Hyatt House Houston Medical Center in Houston
+1-800-716-8490
7329 Fannin St., Houston, TX 77030 ~2.79 miles west of 77221
  • Affordable Suburban property
  • 298 rooms in property
From$99
Average 3.0 /5 Latest Reviews Call BookMore Details
Hyatt Place : 7329a Fannin St.
+1-800-805-5223
7329a Fannin St., Houston, TX 77030 ~2.79 miles west of 77221
  • 3-star property
From$80
Average 3.0 /5 Reviews Call BookMore Details
Houston Marriott Medical Center/Museum District
+1-888-965-1860
6580 Fannin St., Houston, TX 77030 ~2.80 miles west of 77221
  • Four-star Downtown property
  • 26 floors in hotel
From$75
Very Good 4.5 /5 Recent Reviews Call BookMore Details
The Westin Hou Medical Center
+1-888-788-5576
1709 Dryden Rd., Houston, TX 77030 ~2.81 miles west of 77221
  • Midscale hotel
  • 273 rooms in property
From$90
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Sonder at Mid Main - Houston
+1-888-897-9207
3550 Main St., Houston, TX 77002 ~2.87 miles northwest of 77221
  • Mid-scale Downtown property
  • 4 floors in property
From$75
Average 3.0 /5 Recent Reviews Call BookMore Details
Hampton Inn & Suites Houston Medical Center Nrg Park in Houston
+1-888-311-4278
1715 Old Spanish Trail, Houston, TX 77054 ~2.92 miles west of 77221
  • 3-star Convention Center property
  • 37 suites in hotel
From$69
Very Good 4.0 /5 Recent Reviews Call BookMore Details
SureStay Plus by Best Western Houston Medical Center
+1-888-469-4795
6700 Main St., Houston, TX 77030 ~2.94 miles west of 77221
  • Mid-scale Downtown hotel
  • 125 rooms in hotel
From$57
Average 3.5 /5 Read Reviews Call BookMore Details
Intercontinental Houston Medical Center : 6750 Main St.
+1-888-734-9421
6750 Main St., Houston, TX 77030 ~2.98 miles west of 77221
  • Expensive Downtown hotel
  • 37 suites in hotel
From$75
Average 3.0 /5 Reviews Call BookMore Details
Doubletree by Hilton Houston Medical Center Hotel & Suites : 6800 Main St.
+1-888-841-5292
6800 Main St., Houston, TX 77030 ~3.01 miles west of 77221
  • Midscale Downtown property
  • Fitness / Gym is on-site
From$80
Average 3.0 /5 Recent Reviews Call BookMore Details
Extended Stay America - Houston - Med Ctr-NRG Park-Fannin in Houston
+1-888-455-5160
7979 Fannin, Houston, TX 77054 ~3.02 miles west of 77221
  • 2 star Convention Center property
  • Hotel has 153 rooms
Holiday Inn Express Hotel & Suites Houston-Downtown Conv Ctr, an
+1-888-965-8297
1810 Bell St., Houston, TX 77003 ~3.11 miles north of 77221
  • Mid-scale Downtown property
  • Fitness center on property
From$108
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Springhill Suites Marriott
+1-888-906-6358
1400 Old Spanish Trail, Houston, TX 77054 ~3.33 miles west of 77221
  • 3 star Downtown property
  • Free comp. breakfast
From$80
Average 3.0 /5 Reviews Call BookMore Details
Whyhotel Houston Downtown : 1515 Austin St.
+1-888-749-6785
1515 Austin St., Houston, TX 77002 ~3.33 miles north of 77221
  • Three Star property
  • 103 sleeping rooms in hotel
From$90
Very Good 4.0 /5 Review Score Call BookMore Details
Athens Hotel Suites
+1-888-878-9982
1308 Clay St., Houston, TX 77002 ~3.39 miles north of 77221
  • 3 star Downtown hotel
  • Hotel has an eco-friendly policy Read more
From$89
Average 3.0 /5 Reviews Call BookMore Details
Hilton Americas Houston
+1-888-389-4485
1600 Lamar St., Houston, TX 77010 ~3.41 miles north of 77221
  • 4 star Downtown hotel
  • Hotel has 66 suites
From$101
Very Good 4.5 /5 Hotel Reviews Call BookMore Details
La Colombe D Or Hotel
+1-888-389-4121
3410 Montrose Blvd., Houston, TX 77006 ~3.41 miles northwest of 77221
  • Affordable hotel
  • 15 sleeping rooms in hotel
From$90
Average 3.0 /5 Latest Reviews Call BookMore Details
Embassy Suites Houston Downtown
+1-888-675-2083
1515 Dallas, Houston, TX 77010 ~3.43 miles north of 77221
  • 3 star Downtown hotel
  • 19 floors in hotel
From$135
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Sonder Midtown in Houston
+1-800-716-8490
306 Mcgowen St., Houston, TX 77006 ~3.44 miles northwest of 77221
  • Midscale Downtown hotel
  • 11 suites in property
From$75
Average 3.0 /5 Latest Reviews Call BookMore Details
Holiday Inn Houston Downtown, an IHG Hotel
+1-800-805-5223
1616 Main St., Houston, TX 77002 ~3.46 miles north of 77221
  • 3 star Downtown property
  • Gym / Fitness Center Available
Marriott Marquis Houston in Houston
+1-888-965-1860
1777 Walker St., Houston, TX 77010 ~3.47 miles north of 77221
  • 4-star hotel
  • Check in: 16:00
From$375
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Sonder Lofts at Ballpark
+1-888-788-5576
610 St. Emanuel St. Houston Tx 77003, Houston, TX 77003 ~3.48 miles north of 77221
  • Affordable Downtown hotel
  • 22 suites in property
From$100
Average 3.0 /5 Recent Reviews Call BookMore Details
The Reside
+1-888-897-9207
7755 South Main St., Houston, TX 77054 ~3.51 miles west of 77221
  • Midscale Downtown hotel
  • Hotel has an eco-friendly policy See more
From$55
Very Good 4.0 /5 Read Reviews Call BookMore Details
Holiday Inn Houston S - Nrg Area - Medical Center, an IHG Hotel in Houston
+1-888-311-4278
8111 Kirby Dr., Houston, TX 77054 ~3.51 miles west of 77221
  • Affordable Suburban property
  • Hotel has 11 floors
From$126
Average 3.5 /5 Recent Reviews Call BookMore Details
Four Seasons Hotel Houston - Houston
+1-888-469-4795
1300 Lamar St., Houston, TX 77010 ~3.51 miles north of 77221
  • Luxury 5 star Downtown hotel
  • Fitness + Health Center
From$275
Very Good 4.0 /5 Review Score Call BookMore Details
Extended Stay America Suites Houston Med Ctr NRG Park Kirby
+1-888-734-9421
1303 La Concha Ln, Houston, TX 77054 ~3.52 miles west of 77221
  • Economy Convention Center property
  • 84 rooms in hotel
From$41
Average 3.0 /5 Recent Reviews Call BookMore Details
Courtyard by Marriott Houston Medical Center/NRG Park : 7702 Main St.
+1-888-841-5292
7702 Main St., Houston, TX 77030 ~3.55 miles west of 77221
  • Mid-scale Downtown hotel
  • Hotel has an eco-friendly policy See policy
From$80
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Bayou City Event Center in Houston
+1-888-455-5160
9401 Knight Rd., Houston, TX 77045 ~3.56 miles southwest of 77221
  • Low Cost hotel
From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
Residence Inn Houston Medical Center / Nrg Park : 7807 Kirby Dr.
+1-888-965-8297
7807 Kirby Dr., Houston, TX 77030 ~3.56 miles west of 77221
  • Three Star Downtown hotel
  • Comp. Breakfast
From$109
Very Good 4.0 /5 Review Score Call BookMore Details
Moody Manor in Houston
+1-888-906-6358
7706 Main St., Houston, TX 77030 ~3.58 miles west of 77221
  • 3 star Downtown property
  • Hotel has 197 suites
From$69
Average 3.5 /5 Latest Reviews Call BookMore Details
The Laura Hotel, Houston Downtown, Autograph Collection in Houston
+1-888-749-6785
1070 Dallas St., Houston, TX 77002 ~3.58 miles north of 77221
  • Luxurious 5-star Downtown hotel
  • Check-in time: 3:00pm
From$159
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Hampton Inn Houston Downtown in Houston
+1-888-878-9982
710 Crawford St., Houston, TX 77002 ~3.58 miles north of 77221
  • Three Star Convention Center property
  • Hotel has 127 suites
From$89
Very Good 4.0 /5 Reviews Call BookMore Details

Next: Show All Available 77221 Hotels with Pricing

Graph: Upcoming 20 Days of Houston Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Houston, TX discounts available. The chart reflects the cheapest Houston hotel for each day and each star rating category.

FAQs about hotels near 77221

What are the most favored hotels near 77221?

Home2 Suites, Hotel Zaza Houston Museum District and Houston Marriott Medical Center are the best rated hotels based on customer reviews in the last 365 days.

What are the most luxurious hotels near 77221?

Four Seasons Hotel Houston, The Laura Hotel, Houston Downtown, Autograph Collection and Cliù Luxury Boutique Condo Hotel are the top 3 luxury hotels near 77221.

What hotels are closest to the area of 77221?

Cliù Luxury Boutique Condo Hotel, Extended Stay America Suites Houston Med Ctr Greenway Plaza, and Summit Inn are the properties closest to 77221.

How much does a cheap hotel near 77221 cost per night?

In the last year, a 2 star hotel near 77221 can be as cheap as $63.37 per night. (based on HotelPlanner prices)

How much does a 3 star hotel near 77221 cost per night?

In the last year, the average 3 star hotel near 77221 has been $85.49 per night. (based on HotelPlanner prices)

How much does a 4-5 star hotel near 77221 cost?

In the last year, the average 4 star hotel near 77221 has been $111.54 per night. (based on HotelPlanner prices)

What are the best independent hotels near 77221?

Hotel Zaza Houston Museum District, Scott Inn Suites Downtown Houston and Blossom Houston Medical Center are the best rated independent hotels (not part of a big brand).

What are the most popular Marriott hotels near 77221?

Houston Marriott Medical Center, The Westin Hou Medical Center and Marriott Marquis Houston are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the best IHG hotels near 77221?

Holiday Inn Express Hotel & Suites Houston-Downtown Conv Ctr, an, Holiday Inn Houston S - Nrg Area - Medical Center, an IHG Hotel and Holiday Inn Houston Downtown, an IHG Hotel are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

Back to Top