Hotels in 77221 - Houston TX

Only hotels in 77221 zip code are listed below. Search for cheap and discount hotel rates in Houston, TX for your upcoming leisure or conference / group travel. We list the best 77221 hotels and motels so you can review the Houston hotel list below to find the perfect lodging. Hotels in Harris county and area code 713 are also listed.

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77221 Hotels & Accommodations

Cliù Luxury Boutique Condo Hotel - Houston 3144 Southmore Blvd. Unit 10, Houston, TX 77004
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~1.13 miles northwest of 77221
  • Four-star Downtown hotel
  • 8 suites in property
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From$100
Average 3.0 /5 Hotel Reviews Call BookMore Details
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Extended Stay America Suites Houston Med Ctr Greenway Plaza : 2330 Southwest Frwy 2330 Southwest Frwy, Houston, TX 77098
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~1.16 miles west of 77221
  • Inexpensive Downtown hotel
  • Fitness center on property
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From$61
Average 3.0 /5 Reviews Call BookMore Details
Summit Inn - Houston Medical Center 3138 Old Spanish Trail, Houston, TX 77054
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~1.37 miles west of 77221
  • Inexpensive hotel
  • 33 rooms in property
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From$60
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Mainstay Suites Texas Medical Center / Reliant Park 3134 Old Spanish Trail, Houston, TX 77054
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~1.41 miles west of 77221
  • 2-star Convention Center property
  • 89 rooms in hotel
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From$60
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Hilton University of Houston 4800 Calhoun Rd., Houston, TX 77004
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~1.54 miles northeast of 77221
  • Expensive Downtown property
  • Fitness + Health Center
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From$125
Average 3.0 /5 Read Reviews Call BookMore Details
Americas Best Value Inn Medical Center Downtown : 2419 Riverside Dr. 2419 Riverside Dr., Houston, TX 77004
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~1.64 miles northwest of 77221
  • Cheap property
  • Check-in time: 15:00
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From$60
Very Good 4.0 /5 Read Reviews Call BookMore Details
Home2 Suites 6840 Almeda Rd., Houston, TX 77030
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~1.81 miles west of 77221
  • Mid-scale Suburban hotel
  • Fitness center on property
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From$99
Excellent 5.0 /5 Read Reviews Call BookMore Details
Hilton Garden Inn 6840b Almeda Rd., Houston, TX 77030
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~1.81 miles west of 77221
  • 3-star Suburban property
  • Fitness + Health Center
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From$109
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Hilton Garden in Houston 6840 B Almeda Rd., Houston, TX 77030
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~1.82 miles west of 77221
  • Mid-scale hotel
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From$80
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Medical District : 2700 Old Spanish Trail 2700 Old Spanish Trail, Houston, TX 77021
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~1.92 miles west of 77221
  • High end property
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From$75
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Sonder The Hampstead - Houston 1508 Blodgett, Houston, TX 77004
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~2.32 miles northwest of 77221
  • 3-star Downtown hotel
  • Check in: 4:00 PM
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From$80
Average 3.0 /5 Review Score Call BookMore Details
Scott Inn Suites Downtown Houston in Houston 1933 Scott St., Houston, TX 77003
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~2.34 miles north of 77221
  • Midscale property
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From$90
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Best Way Inn Houston - Medical Center in Houston 3100 Holmes Rd., Houston, TX 77051
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~2.49 miles southwest of 77221
  • Two-star hotel
  • 42 sleeping rooms in hotel
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From$60
Average 3.0 /5 Recent Reviews Call BookMore Details
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Extended Stay America Suites Houston Med Ctr Braeswood Bl : 1301 Braeswood Blvd. 1301 Braeswood Blvd., Houston, TX 77030
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~2.52 miles west of 77221
  • 3-star Convention Center property
  • Check-in: 3:00pm
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From$64
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Hotel Zaza Houston Museum District : 5701 Main St. 5701 Main St., Houston, TX 77005
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~2.57 miles northwest of 77221
  • Four star Downtown property
  • Hotel has 12 floors
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From$159
Very Good 4.5 /5 Review Score Call BookMore Details
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Blossom Houston Medical Center : 7114 Bertner Ave. 7114 Bertner Ave., Houston, TX 77030
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~2.68 miles west of 77221
  • Midscale hotel
  • Check in: 16:00
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From$90
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Blossom Hotel Houston 7118 Bertner Ave., Houston, TX 77030
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~2.68 miles west of 77221
  • High end Convention Center property
  • 267 rooms in hotel
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From$169
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Days Inn & Suites by Wyndham Downtown / University of Houston 6190 Gulf Freeway, Houston, TX 77023
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~2.72 miles east of 77221
  • 3-star Downtown property
  • Check-in: 2:00pm
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From$55
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Lexington Hotel Houston Medical Center - Houston 1025 Swanson St., Houston, TX 77030
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~2.78 miles west of 77221
  • Cheap Downtown property
  • Fitness / Gym is on-site
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From$60
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Hyatt Place : 7329a Fannin St. 7329a Fannin St., Houston, TX 77030
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~2.78 miles west of 77221
  • Mid-scale hotel
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From$80
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Hyatt Place Hyatt House Houston Medical Center : 7329 Fannin St. 7329 Fannin St., Houston, TX 77030
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~2.78 miles west of 77221
  • 3-star Suburban hotel
  • Hotel has 14 floors
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From$99
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Houston Marriott Medical Center/Museum District 6580 Fannin St., Houston, TX 77030
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~2.80 miles west of 77221
  • Four star Downtown property
  • Access to gym on-site
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From$75
Very Good 4.5 /5 Review Score Call BookMore Details
The Westin Hou Medical Center 1709 Dryden Rd., Houston, TX 77030
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~2.81 miles west of 77221
  • Midscale property
  • Gym / Fitness Center Available
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From$90
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Sonder at Mid Main in Houston 3550 Main St., Houston, TX 77002
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~2.86 miles northwest of 77221
  • Affordable Downtown property
  • Hotel has 26 rooms
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From$75
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Hampton Inn & Suites Houston Medical Center Nrg Park 1715 Old Spanish Trail, Houston, TX 77054
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~2.91 miles west of 77221
  • Midscale Convention Center property
  • 37 suites in hotel
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From$69
Very Good 4.0 /5 Review Score Call BookMore Details
Houston Medical Center Hotel 6700 Main St., Houston, TX 77030
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~2.94 miles west of 77221
  • 3 star Downtown hotel
  • Check-in time: 03:00
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From$115
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InterContinental Houston by IHG - Houston 6750 Main St., Houston, TX 77030
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~2.98 miles west of 77221
  • High-end Downtown property
  • Hotel has 21 floors
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From$75
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Doubletree by Hilton Houston Medical Center Hotel & Suites - Houston 6800 Main St., Houston, TX 77030
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~3.01 miles west of 77221
  • Expensive Downtown hotel
  • Shuttle from airport available
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From$125
Average 3.0 /5 Review Score Call BookMore Details
Extended Stay America - Houston - Med Ctr-NRG Park-Fannin - Houston 7979 Fannin, Houston, TX 77054
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~3.01 miles west of 77221
  • Low Cost Convention Center hotel
  • Check in time: 3pm
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From$49
Poor 2.5 /5 Latest Reviews Call BookMore Details
Holiday Inn Express Houston Downtown 1810 Bell St., Houston, TX 77003
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~3.10 miles north of 77221
  • 3 star Downtown property
  • Has environment-friendly policy Read more
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From$80
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Wanderstay Boutique Hotel : 520 Sampson St. 520 Sampson St., Houston, TX 77003
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~3.15 miles north of 77221
  • High end hotel
  • 10 rooms in property
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From$125
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SpringHill Suites Houston Medical Center/NRG Park in Houston 1400 Old Spanish Trl, Houston, TX 77054
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~3.32 miles west of 77221
  • Midscale Downtown hotel
  • 190 rooms in hotel
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From$80
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Whyhotel Houston Downtown - Houston 1515 Austin St., Houston, TX 77002
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~3.33 miles north of 77221
  • Three Star property
  • Check-in time: 15:00
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From$90
Very Good 4.0 /5 Review Score Call BookMore Details
Athens Hotel Suites 1308 Clay St., Houston, TX 77002
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~3.39 miles north of 77221
  • Midscale Downtown property
  • Has environment-friendly policy Read more
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From$89
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La Colombe D Or Hotel - Houston 3410 Montrose Blvd., Houston, TX 77006
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~3.40 miles northwest of 77221
  • 3 star hotel
  • Hotel has 2 floors
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From$90
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Hilton Americas Houston : 1600 Lamar St. 1600 Lamar St., Houston, TX 77010
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~3.40 miles north of 77221
  • Four star Downtown property
  • Hotel has an eco-friendly policy Learn more
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From$101
Very Good 4.5 /5 Guest Reviews Call BookMore Details
Hotel Saint Augustine in Houston 4110 Loretto Dr., Houston, TX 77006
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~3.41 miles northwest of 77221
  • High end Downtown property
  • 2 floors in property
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From$401
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Embassy Suites Houston Downtown 1515 Dallas, Houston, TX 77010
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~3.42 miles north of 77221
  • Mid-scale Downtown hotel
  • 262 rooms in hotel
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From$135
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Sonder Midtown - Houston 306 Mcgowen St., Houston, TX 77006
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~3.44 miles northwest of 77221
  • Three Star Downtown hotel
  • 11 rooms in property
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From$75
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Holiday Inn Houston Downtown by IHG - Houston 1616 Main St., Houston, TX 77002
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~3.46 miles north of 77221
  • Affordable Downtown property
  • Gym is available on property
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From$79
Poor 2.0 /5 Hotel Reviews Call BookMore Details
Marriott Marquis Houston 1777 Walker St., Houston, TX 77010
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~3.46 miles north of 77221
  • 4-star hotel
  • 1000 sleeping rooms in hotel
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From$375
Very Good 4.0 /5 Read Reviews Call BookMore Details
Courtyard by Marriott Houston Medical Center/NRG Park Houston Medical Center 7702 Main St., Houston, TX 77030
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~3.47 miles west of 77221
  • Affordable Suburban hotel
  • 3 meeting rooms in property
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From$69
Very Good 4.0 /5 Review Score Call BookMore Details
Sonder Lofts at Ballpark in Houston 610 St. Emanuel St. Houston Tx 77003, Houston, TX 77003
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~3.47 miles north of 77221
  • 3-star Downtown hotel
  • Gym / Fitness Center Available
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From$100
Average 3.0 /5 Review Score Call BookMore Details
The Reside 7755 South Main St., Houston, TX 77054
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~3.50 miles west of 77221
  • 3 star Downtown hotel
  • Fitness center on property
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From$55
Very Good 4.0 /5 Read Reviews Call BookMore Details
Holiday Inn Houston S - Nrg Area - Medical Center by IHG in Houston 8111 Kirby Dr., Houston, TX 77054
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~3.50 miles west of 77221
  • 3-star Suburban hotel
  • Hotel has 6 suites
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From$126
Average 3.5 /5 Review Score Call BookMore Details
Four Seasons Hotel Houston : 1300 Lamar St. 1300 Lamar St., Houston, TX 77010
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~3.51 miles north of 77221
  • Luxury Five Star Downtown hotel
  • 404 rooms in hotel
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From$275
Very Good 4.0 /5 Reviews Call BookMore Details
Extended Stay America Suites Houston Med Ctr NRG Park Kirby 1303 La Concha Ln, Houston, TX 77054
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~3.52 miles west of 77221
  • Inexpensive Convention Center hotel
  • Complimentary breakfast is offered
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From$41
Average 3.0 /5 Latest Reviews Call BookMore Details
Courtyard Houston Medical Center / Nrg Park : 7702 Main St. 7702 Main St., Houston, TX 77030
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~3.55 miles west of 77221
  • 3 star Downtown hotel
  • Fitness / Gym is on-site
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From$80
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Bayou City Event Center 9401 Knight Rd., Houston, TX 77045
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~3.55 miles southwest of 77221
  • Low Cost hotel
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From$60
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Residence Inn Houston Medical Center / Nrg Park - Houston 7807 Kirby Dr., Houston, TX 77030
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~3.56 miles west of 77221
  • Midscale Downtown property
  • Check in time: 4:00 PM
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From$109
Very Good 4.0 /5 Reviews Call BookMore Details

Next: Show All Available 77221 Hotels with Pricing

Graph: Upcoming 20 Days of Houston Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Houston, TX discounts available. The chart reflects the cheapest Houston hotel for each day and each star rating category.

FAQs about hotels near 77221

What are the most favored hotels near 77221?

Home2 Suites, Hotel Zaza Houston Museum District and Houston Marriott Medical Center are the best rated hotels based on customer reviews in the last 365 days.

What are the most luxurious hotels near 77221?

Four Seasons Hotel Houston, Cliù Luxury Boutique Condo Hotel and Hilton University of Houston are the top 3 luxury hotels near 77221.

What hotels are closest to the area of 77221?

Cliù Luxury Boutique Condo Hotel, Extended Stay America Suites Houston Med Ctr Greenway Plaza, and Summit Inn - Houston Medical Center are the properties closest to 77221.

How much does a cheap hotel near 77221 cost per night?

In the last year, a 2 star hotel near 77221 can be as cheap as $63.37 per night. (based on HotelPlanner prices)

How much does a 3 star hotel near 77221 cost per night?

In the last year, the average 3 star hotel near 77221 has been $85.49 per night. (based on HotelPlanner prices)

How much does a 4-5 star hotel near 77221 cost?

In the last year, the average 4 star hotel near 77221 has been $111.54 per night. (based on HotelPlanner prices)

What are the best independent hotels near 77221?

Hotel Zaza Houston Museum District, Scott Inn Suites Downtown Houston and Blossom Houston Medical Center are the best rated independent hotels (not part of a big brand).

What are the most popular Marriott hotels near 77221?

Houston Marriott Medical Center, The Westin Hou Medical Center and Marriott Marquis Houston are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the best IHG hotels near 77221?

Holiday Inn Houston S - Nrg Area - Medical Center by IHG, Holiday Inn Houston Downtown by IHG and InterContinental Houston by IHG are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

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