Star Rating
Hotel Name
Price Range (USD) to
Amenities
+ More

77221 Hotels, Motels & Accommodations

Cliù Luxury Boutique Condo Hotel : 3144 Southmore Blvd. Unit 10
+1-888-389-4121
3144 Southmore Blvd. Unit 10, Houston, TX 77004 ~1.13 miles northwest of 77221
  • Expensive Downtown property
  • 2 floors in property
From$100
Average 3.0 /5 Review Score Call BookMore Details
Tired of clicking around? Talk to an expert Hotel Planner: (855) 276-7561 or say...
alexa hotel planner skill"Alexa, ask Hotel Planner to make a new reservation in 77221" Get Alexa Skill →
Extended Stay America Suites Houston Med Ctr Greenway Plaza - Houston
+1-888-675-2083
2330 Southwest Frwy, Houston, TX 77098 ~1.16 miles west of 77221
  • Cheap Downtown property
  • Free comp. breakfast
From$61
Average 3.0 /5 Hotel Reviews Call BookMore Details
Summit Inn - Houston Medical Center
+1-800-716-8490
3138 Old Spanish Trail, Houston, TX 77054 ~1.37 miles west of 77221
  • Inexpensive hotel
  • Check-in: 11:00
From$60
Average 3.0 /5 Recent Reviews Call BookMore Details
MainStay Suites Texas Medical Center/Reliant Park : 3134 Old Spanish Trail
+1-800-805-5223
3134 Old Spanish Trail, Houston, TX 77054 ~1.41 miles west of 77221
  • Low-priced Convention Center hotel
  • Gym / Fitness Center Available
From$60
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Hilton University of Houston
+1-888-965-1860
4800 Calhoun Rd., Houston, TX 77004 ~1.54 miles northeast of 77221
  • Four star Downtown property
  • 12 suites in hotel
From$125
Average 3.0 /5 Guest Reviews Call BookMore Details
Americas Best Value Inn Medical Center Downtown in Houston
+1-888-788-5576
2419 Riverside Dr., Houston, TX 77004 ~1.64 miles northwest of 77221
  • Cheap hotel
  • Hotel has 40 rooms
From$60
Very Good 4.0 /5 Read Reviews Call BookMore Details
Home2 Suites
+1-888-897-9207
6840 Almeda Rd., Houston, TX 77030 ~1.81 miles west of 77221
  • 3-star Suburban hotel
  • 3 meeting rooms in hotel
From$99
Excellent 5.0 /5 Review Score Call BookMore Details
Hilton Garden Inn : 6840b Almeda Rd.
+1-888-311-4278
6840b Almeda Rd., Houston, TX 77030 ~1.81 miles west of 77221
  • 3-star Suburban hotel
  • Gym / Fitness Center Available
From$109
Average 3.0 /5 Hotel Reviews Call BookMore Details
Hilton Garden - Houston
+1-888-469-4795
6840 B Almeda Rd., Houston, TX 77030 ~1.82 miles west of 77221
  • Mid-scale hotel
From$80
Average 3.0 /5 Read Reviews Call BookMore Details
Medical District : 2700 Old Spanish Trail
+1-888-734-9421
2700 Old Spanish Trail, Houston, TX 77021 ~1.92 miles west of 77221
  • Four-star hotel
From$75
Average 3.0 /5 Guest Reviews Call BookMore Details
Sonder The Hampstead : 1508 Blodgett
+1-888-841-5292
1508 Blodgett, Houston, TX 77004 ~2.32 miles northwest of 77221
  • Midscale Downtown property
  • 36 suites in property
From$80
Average 3.0 /5 Guest Reviews Call BookMore Details
Scott Inn Suites Downtown Houston
+1-888-455-5160
1933 Scott St., Houston, TX 77003 ~2.34 miles north of 77221
  • Three Star property
  • 2 floors in hotel
From$90
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Best Way Inn Houston - Medical Center
+1-888-965-8297
3100 Holmes Rd., Houston, TX 77051 ~2.49 miles southwest of 77221
  • Economical hotel
  • Hotel has 42 rooms
From$60
Average 3.0 /5 Recent Reviews Call BookMore Details
Extended Stay America Suites Houston Med Ctr Braeswood Bl
+1-888-906-6358
1301 Braeswood Blvd., Houston, TX 77030 ~2.52 miles west of 77221
  • 3-star Convention Center property
  • 4 suites in property
From$64
Average 3.0 /5 Read Reviews Call BookMore Details
Hotel Zaza Houston Museum District - Houston
+1-888-749-6785
5701 Main St., Houston, TX 77005 ~2.57 miles northwest of 77221
  • Expensive Downtown property
  • 15 meeting rooms in property
From$159
Very Good 4.5 /5 Recent Reviews Call BookMore Details
Need some questions answered? Talk to an expert Hotel Planner: (855) 276-7561 or say...
alexa hotel planner skill"Alexa, ask Hotel Planner to make a new reservation in 77221" Get Alexa Skill →
Blossom Houston Medical Center in Houston
+1-888-878-9982
7114 Bertner Ave., Houston, TX 77030 ~2.68 miles west of 77221
  • Midscale hotel
  • 230 sleeping rooms in hotel
From$90
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Blossom Hotel Houston
+1-888-389-4485
7118 Bertner Ave., Houston, TX 77030 ~2.68 miles west of 77221
  • 4 star Convention Center property
  • 37 suites in property
From$169
Average 3.0 /5 Guest Reviews Call BookMore Details
Days Inn & Suites by Wyndham Downtown / University of Houston in Houston
+1-888-389-4121
6190 Gulf Freeway, Houston, TX 77023 ~2.72 miles east of 77221
  • Three Star Downtown property
  • 2 floors in property
From$55
Average 3.0 /5 Latest Reviews Call BookMore Details
Lexington Hotel Houston Medical Center : 1025 Swanson St.
+1-888-675-2083
1025 Swanson St., Houston, TX 77030 ~2.78 miles west of 77221
  • Economical Downtown property
  • Free complimentary breakfast
From$60
Average 3.5 /5 Latest Reviews Call BookMore Details
Hyatt Place : 7329a Fannin St.
+1-800-716-8490
7329a Fannin St., Houston, TX 77030 ~2.78 miles west of 77221
  • 3-star property
From$80
Average 3.0 /5 Recent Reviews Call BookMore Details
Hyatt Place Hyatt House Houston Medical Center - Houston
+1-800-805-5223
7329 Fannin St., Houston, TX 77030 ~2.78 miles west of 77221
  • 3 star Suburban property
  • 14 floors in property
From$99
Average 3.0 /5 Guest Reviews Call BookMore Details
Houston Marriott Medical Center/Museum District
+1-888-965-1860
6580 Fannin St., Houston, TX 77030 ~2.80 miles west of 77221
  • High end Downtown property
  • 26 floors in hotel
From$75
Very Good 4.5 /5 Hotel Reviews Call BookMore Details
The Westin Hou Medical Center : 1709 Dryden Rd.
+1-888-788-5576
1709 Dryden Rd., Houston, TX 77030 ~2.81 miles west of 77221
  • Three Star hotel
  • Fitness + Health Center
From$90
Very Good 4.0 /5 Review Score Call BookMore Details
Sonder at Mid Main in Houston
+1-888-897-9207
3550 Main St., Houston, TX 77002 ~2.86 miles northwest of 77221
  • Three Star Downtown property
  • 4 floors in hotel
From$75
Average 3.0 /5 Review Score Call BookMore Details
Hampton Inn & Suites Houston Medical Center Nrg Park - Houston
+1-888-311-4278
1715 Old Spanish Trail, Houston, TX 77054 ~2.91 miles west of 77221
  • 3-star Convention Center hotel
  • Hotel has 37 suites
From$69
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Houston Medical Center Hotel in Houston
+1-888-469-4795
6700 Main St., Houston, TX 77030 ~2.94 miles west of 77221
  • Mid-scale Downtown hotel
  • 25 suites in hotel
From$115
Average 3.5 /5 Latest Reviews Call BookMore Details
InterContinental Houston by IHG
+1-888-734-9421
6750 Main St., Houston, TX 77030 ~2.98 miles west of 77221
  • Four-star Downtown hotel
  • 354 rooms in hotel
From$75
Average 3.0 /5 Read Reviews Call BookMore Details
Doubletree by Hilton Houston Medical Center Hotel & Suites : 6800 Main St.
+1-888-841-5292
6800 Main St., Houston, TX 77030 ~3.01 miles west of 77221
  • Four-star Downtown hotel
  • 12 floors in hotel
From$125
Average 3.0 /5 Hotel Reviews Call BookMore Details
Extended Stay America - Houston - Med Ctr-NRG Park-Fannin : 7979 Fannin
+1-888-455-5160
7979 Fannin, Houston, TX 77054 ~3.01 miles west of 77221
  • Two star Convention Center hotel
  • 153 sleeping rooms in hotel
Holiday Inn Express Houston Downtown in Houston
+1-888-965-8297
1810 Bell St., Houston, TX 77003 ~3.10 miles north of 77221
  • 3 star Downtown hotel
  • Free comp. breakfast
From$80
Average 3.0 /5 Review Score Call BookMore Details
Wanderstay Boutique Hotel
+1-888-906-6358
520 Sampson St., Houston, TX 77003 ~3.15 miles north of 77221
  • 4-star hotel
  • Check in: 2:00PM CST
From$125
Average 3.0 /5 Read Reviews Call BookMore Details
SpringHill Suites Houston Medical Center/NRG Park
+1-888-749-6785
1400 Old Spanish Trl, Houston, TX 77054 ~3.32 miles west of 77221
  • Three Star Downtown hotel
  • 190 rooms in property
From$80
Average 3.0 /5 Hotel Reviews Call BookMore Details
Whyhotel Houston Downtown - Houston
+1-888-878-9982
1515 Austin St., Houston, TX 77002 ~3.33 miles north of 77221
  • 3-star property
From$90
Very Good 4.0 /5 Read Reviews Call BookMore Details
Athens Hotel Suites in Houston
+1-888-389-4485
1308 Clay St., Houston, TX 77002 ~3.39 miles north of 77221
  • Midscale Downtown hotel
  • Fitness / Gym is on-site
From$89
Average 3.0 /5 Hotel Reviews Call BookMore Details
La Colombe D Or Hotel : 3410 Montrose Blvd.
+1-888-389-4121
3410 Montrose Blvd., Houston, TX 77006 ~3.40 miles northwest of 77221
  • Affordable hotel
  • Hotel has 2 floors
From$90
Average 3.0 /5 Latest Reviews Call BookMore Details
Hilton Americas Houston - Houston
+1-888-675-2083
1600 Lamar St., Houston, TX 77010 ~3.40 miles north of 77221
  • High end Downtown property
  • Check in time: 3:00 PM
From$101
Very Good 4.5 /5 Guest Reviews Call BookMore Details
Hotel Saint Augustine : 4110 Loretto Dr.
+1-800-716-8490
4110 Loretto Dr., Houston, TX 77006 ~3.41 miles northwest of 77221
  • 4-star Downtown hotel
  • 2 floors in property
From$401
Average 3.0 /5 Review Score Call BookMore Details
Embassy Suites Houston Downtown in Houston
+1-800-805-5223
1515 Dallas, Houston, TX 77010 ~3.42 miles north of 77221
  • 3 star Downtown property
  • Hotel has 19 floors
From$135
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Sonder Midtown
+1-888-965-1860
306 Mcgowen St., Houston, TX 77006 ~3.44 miles northwest of 77221
  • Mid-scale Downtown hotel
  • 6 floors in hotel
From$75
Average 3.0 /5 Review Score Call BookMore Details
Holiday Inn Houston Downtown by IHG in Houston
+1-888-788-5576
1616 Main St., Houston, TX 77002 ~3.46 miles north of 77221
  • Three Star Downtown hotel
  • 16 floors in property
Marriott Marquis Houston
+1-888-897-9207
1777 Walker St., Houston, TX 77010 ~3.46 miles north of 77221
  • High end property
  • Gym / Fitness Center Available
From$375
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Courtyard by Marriott Houston Medical Center/NRG Park
+1-888-311-4278
Houston Medical Center 7702 Main St., Houston, TX 77030 ~3.47 miles west of 77221
  • Mid-scale Suburban hotel
  • Access to gym on-site
From$69
Very Good 4.0 /5 Read Reviews Call BookMore Details
Sonder Lofts at Ballpark : 610 St. Emanuel St. Houston Tx 77003
+1-888-469-4795
610 St. Emanuel St. Houston Tx 77003, Houston, TX 77003 ~3.47 miles north of 77221
  • Three Star Downtown property
  • Hotel has 6 floors
From$100
Average 3.0 /5 Recent Reviews Call BookMore Details
The Reside - Houston
+1-888-734-9421
7755 South Main St., Houston, TX 77054 ~3.50 miles west of 77221
  • 3-star Downtown hotel
  • 3 floors in hotel
From$55
Very Good 4.0 /5 Review Score Call BookMore Details
Holiday Inn Houston S - Nrg Area - Medical Center by IHG in Houston
+1-888-841-5292
8111 Kirby Dr., Houston, TX 77054 ~3.50 miles west of 77221
  • Midscale Suburban hotel
  • Gym / Fitness Center Available
From$126
Average 3.5 /5 Read Reviews Call BookMore Details
Four Seasons Hotel Houston
+1-888-455-5160
1300 Lamar St., Houston, TX 77010 ~3.51 miles north of 77221
  • Luxury Five Star Downtown property
  • Hotel has 115 suites
From$275
Very Good 4.0 /5 Read Reviews Call BookMore Details
Extended Stay America Suites Houston Med Ctr NRG Park Kirby - Houston
+1-888-965-8297
1303 La Concha Ln, Houston, TX 77054 ~3.52 miles west of 77221
  • Economical Convention Center property
  • 3 floors in property
From$41
Average 3.0 /5 Recent Reviews Call BookMore Details
Courtyard Houston Medical Center / Nrg Park - Houston
+1-888-906-6358
7702 Main St., Houston, TX 77030 ~3.55 miles west of 77221
  • 3 star Downtown hotel
  • Check in: 03:00 PM
From$80
Average 3.0 /5 Read Reviews Call BookMore Details
Bayou City Event Center : 9401 Knight Rd.
+1-888-749-6785
9401 Knight Rd., Houston, TX 77045 ~3.55 miles southwest of 77221
  • Cheap property
From$60
Average 3.0 /5 Read Reviews Call BookMore Details
Residence Inn Houston Medical Center / Nrg Park - Houston
+1-888-878-9982
7807 Kirby Dr., Houston, TX 77030 ~3.56 miles west of 77221
  • 3 star Downtown hotel
  • 182 rooms in hotel
From$109
Very Good 4.0 /5 Latest Reviews Call BookMore Details

Next: Show All Available 77221 Hotels with Pricing

Graph: Upcoming 20 Days of Houston Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Houston, TX discounts available. The chart reflects the cheapest Houston hotel for each day and each star rating category.

FAQs about hotels near 77221

What are the most favored hotels near 77221?

Home2 Suites, Hotel Zaza Houston Museum District and Houston Marriott Medical Center are the best rated hotels based on customer reviews in the last 365 days.

What are the most luxurious hotels near 77221?

Four Seasons Hotel Houston, Cliù Luxury Boutique Condo Hotel and Hilton University of Houston are the top 3 luxury hotels near 77221.

What hotels are closest to the area of 77221?

Cliù Luxury Boutique Condo Hotel, Extended Stay America Suites Houston Med Ctr Greenway Plaza, and Summit Inn - Houston Medical Center are the properties closest to 77221.

How much does a cheap hotel near 77221 cost per night?

In the last year, a 2 star hotel near 77221 can be as cheap as $63.37 per night. (based on HotelPlanner prices)

How much does a 3 star hotel near 77221 cost per night?

In the last year, the average 3 star hotel near 77221 has been $85.49 per night. (based on HotelPlanner prices)

How much does a 4-5 star hotel near 77221 cost?

In the last year, the average 4 star hotel near 77221 has been $111.54 per night. (based on HotelPlanner prices)

What are the best independent hotels near 77221?

Hotel Zaza Houston Museum District, Scott Inn Suites Downtown Houston and Blossom Houston Medical Center are the best rated independent hotels (not part of a big brand).

What are the most popular Marriott hotels near 77221?

Houston Marriott Medical Center, The Westin Hou Medical Center and Marriott Marquis Houston are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the best IHG hotels near 77221?

Holiday Inn Houston S - Nrg Area - Medical Center by IHG, Holiday Inn Houston Downtown by IHG and InterContinental Houston by IHG are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

Back to Top