Hotels in 77221 - Houston TX

Only hotels in 77221 zip code are listed below. Search for cheap and discount hotel rates in Houston, TX for your upcoming leisure or conference / group travel. We list the best 77221 hotels and motels so you can review the Houston hotel list below to find the perfect lodging. Hotels in Harris county and area code 713 are also listed.

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77221 Hotels/Motels & Accommodations

Cliù Luxury Boutique Condo Hotel 3144 Southmore Blvd. Unit 10, Houston, TX 77004
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~1.13 miles northwest of 77221
  • 4 star Downtown property
  • 8 suites in property
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From$100
Average 3.0 /5 Review Score Call BookMore Details
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Extended Stay America Suites Houston Med Ctr Greenway Plaza in Houston 2330 Southwest Frwy, Houston, TX 77098
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~1.16 miles west of 77221
  • Cheap Downtown hotel
  • 3 floors in property
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From$61
Average 3.0 /5 Hotel Reviews Call BookMore Details
Summit Inn - Houston Medical Center : 3138 Old Spanish Trail 3138 Old Spanish Trail, Houston, TX 77054
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~1.37 miles west of 77221
  • Economical property
  • 33 rooms in hotel
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From$60
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Mainstay Suites Texas Medical Center / Reliant Park : 3134 Old Spanish Trail 3134 Old Spanish Trail, Houston, TX 77054
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~1.41 miles west of 77221
  • Economical Convention Center hotel
  • Check-in: 11:00
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From$60
Very Good 4.0 /5 Review Score Call BookMore Details
Hilton University of Houston - Houston 4800 Calhoun Rd., Houston, TX 77004
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~1.54 miles northeast of 77221
  • High-end Downtown hotel
  • Check-in time: 3:00PM
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From$125
Average 3.0 /5 Review Score Call BookMore Details
Americas Best Value Inn Medical Center Downtown in Houston 2419 Riverside Dr., Houston, TX 77004
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~1.64 miles northwest of 77221
  • Inexpensive hotel
  • 2 floors in hotel
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From$60
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Home2 Suites in Houston 6840 Almeda Rd., Houston, TX 77030
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~1.81 miles west of 77221
  • Midscale Suburban property
  • Hotel has 143 suites
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From$99
Excellent 5.0 /5 Hotel Reviews Call BookMore Details
Hilton Garden Inn 6840b Almeda Rd., Houston, TX 77030
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~1.81 miles west of 77221
  • Affordable Suburban hotel
  • Check in: 3:00 PM
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From$109
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Hilton Garden 6840 B Almeda Rd., Houston, TX 77030
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~1.82 miles west of 77221
  • Midscale hotel
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From$80
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Medical District - Houston 2700 Old Spanish Trail, Houston, TX 77021
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~1.92 miles west of 77221
  • High end hotel
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From$75
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Sonder The Hampstead 1508 Blodgett, Houston, TX 77004
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~2.32 miles northwest of 77221
  • 3 star Downtown property
  • Hotel has 36 rooms
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From$80
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Scott Inn Suites Downtown Houston : 1933 Scott St. 1933 Scott St., Houston, TX 77003
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~2.34 miles north of 77221
  • 3 star property
  • Check in time: 15:00
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From$90
Very Good 4.0 /5 Review Score Call BookMore Details
Best Way Inn Houston - Medical Center in Houston 3100 Holmes Rd., Houston, TX 77051
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~2.49 miles southwest of 77221
  • Low Cost hotel
  • 42 rooms in property
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From$60
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Extended Stay America Suites Houston Med Ctr Braeswood Bl : 1301 Braeswood Blvd. 1301 Braeswood Blvd., Houston, TX 77030
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~2.52 miles west of 77221
  • Affordable Convention Center hotel
  • 3 floors in hotel
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From$64
Average 3.0 /5 Guest Reviews Call BookMore Details
Hotel Zaza Houston Museum District : 5701 Main St. 5701 Main St., Houston, TX 77005
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~2.57 miles northwest of 77221
  • Expensive Downtown property
  • 12 floors in hotel
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From$159
Very Good 4.5 /5 Hotel Reviews Call BookMore Details
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Blossom Houston Medical Center 7114 Bertner Ave., Houston, TX 77030
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~2.68 miles west of 77221
  • Mid-scale property
  • Check in time: 16:00
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From$90
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Blossom Hotel Houston in Houston 7118 Bertner Ave., Houston, TX 77030
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~2.68 miles west of 77221
  • Four star Convention Center property
  • Hotel has 37 suites
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From$169
Average 3.0 /5 Reviews Call BookMore Details
Days Inn & Suites by Wyndham Downtown / University of Houston - Houston 6190 Gulf Freeway, Houston, TX 77023
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~2.72 miles east of 77221
  • 3 star Downtown property
  • Access to gym on-site
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From$55
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Lexington Hotel Houston Medical Center 1025 Swanson St., Houston, TX 77030
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~2.78 miles west of 77221
  • Cheap Downtown property
  • Access to gym on-site
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From$60
Average 3.5 /5 Guest Reviews Call BookMore Details
Hyatt Place in Houston 7329a Fannin St., Houston, TX 77030
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~2.78 miles west of 77221
  • Three Star hotel
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From$80
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Hyatt Place Hyatt House Houston Medical Center - Houston 7329 Fannin St., Houston, TX 77030
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~2.78 miles west of 77221
  • 3-star Suburban property
  • Hotel has 14 floors
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From$99
Average 3.0 /5 Recent Reviews Call BookMore Details
Houston Marriott Medical Center/Museum District : 6580 Fannin St. 6580 Fannin St., Houston, TX 77030
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~2.80 miles west of 77221
  • 4-star Downtown hotel
  • Fitness + Health Center
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From$75
Very Good 4.5 /5 Read Reviews Call BookMore Details
The Westin Hou Medical Center 1709 Dryden Rd., Houston, TX 77030
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~2.81 miles west of 77221
  • Mid-scale property
  • Check-in time: 15:00
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From$90
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Sonder at Mid Main 3550 Main St., Houston, TX 77002
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~2.86 miles northwest of 77221
  • 3-star Downtown property
  • Hotel has 26 rooms
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From$75
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Hampton Inn & Suites Houston Medical Center Nrg Park - Houston 1715 Old Spanish Trail, Houston, TX 77054
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~2.91 miles west of 77221
  • Mid-scale Convention Center property
  • 37 suites in property
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From$69
Very Good 4.0 /5 Reviews Call BookMore Details
Houston Medical Center Hotel 6700 Main St., Houston, TX 77030
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~2.94 miles west of 77221
  • 3-star Downtown property
  • Free breakfast
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From$115
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InterContinental Houston by IHG - Houston 6750 Main St., Houston, TX 77030
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~2.98 miles west of 77221
  • 4 star Downtown hotel
  • Check in: 15:00
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From$75
Average 3.0 /5 Latest Reviews Call BookMore Details
Doubletree by Hilton Houston Medical Center Hotel & Suites : 6800 Main St. 6800 Main St., Houston, TX 77030
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~3.01 miles west of 77221
  • Expensive Downtown hotel
  • Airport shuttle available
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From$125
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Extended Stay America - Houston - Med Ctr-NRG Park-Fannin 7979 Fannin, Houston, TX 77054
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~3.01 miles west of 77221
  • Low Cost Convention Center property
  • Hotel has 153 rooms
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From$49
Poor 2.5 /5 Reviews Call BookMore Details
Best Western Premier Houston Downtown/Convention Center Hotel in Houston 1810 Bell St., Houston, TX 77003
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~3.12 miles north of 77221
  • Three Star Downtown property
  • Comp. Breakfast
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From$80
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Wanderstay Boutique Hotel : 520 Sampson St. 520 Sampson St., Houston, TX 77003
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~3.15 miles north of 77221
  • Four-star hotel
  • 2 suites in property
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From$125
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SpringHill Suites Houston Medical Center/NRG Park : 1400 Old Spanish Trl 1400 Old Spanish Trl, Houston, TX 77054
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~3.32 miles west of 77221
  • Midscale Downtown hotel
  • 190 suites in hotel
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From$80
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Whyhotel Houston Downtown 1515 Austin St., Houston, TX 77002
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~3.33 miles north of 77221
  • Affordable hotel
  • Check-in time: 15:00
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From$90
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Athens Hotel Suites : 1308 Clay St. 1308 Clay St., Houston, TX 77002
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~3.39 miles north of 77221
  • 3-star Downtown property
  • Free breakfast available
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From$89
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La Colombe D Or Hotel 3410 Montrose Blvd., Houston, TX 77006
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~3.40 miles northwest of 77221
  • 3-star property
  • 15 sleeping rooms in hotel
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From$90
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Hilton Americas Houston 1600 Lamar St., Houston, TX 77010
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~3.40 miles north of 77221
  • High-end Downtown hotel
  • Hotel has 1200 rooms
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From$101
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Hotel Saint Augustine in Houston 4110 Loretto Dr., Houston, TX 77006
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~3.41 miles northwest of 77221
  • Expensive Downtown hotel
  • 2 floors in property
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From$401
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Embassy Suites Houston Downtown : 1515 Dallas 1515 Dallas, Houston, TX 77010
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~3.42 miles north of 77221
  • Midscale Downtown property
  • Free breakfast available
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From$135
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Sonder Midtown : 306 Mcgowen St. 306 Mcgowen St., Houston, TX 77006
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~3.44 miles northwest of 77221
  • Mid-scale Downtown property
  • 6 floors in hotel
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From$75
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Holiday Inn Houston Downtown by IHG 1616 Main St., Houston, TX 77002
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~3.46 miles north of 77221
  • Affordable Downtown hotel
  • Fitness / Gym is on-site
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From$79
Poor 2.0 /5 Read Reviews Call BookMore Details
Marriott Marquis Houston in Houston 1777 Walker St., Houston, TX 77010
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~3.46 miles north of 77221
  • Expensive hotel
  • Hotel has 29 floors
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From$375
Very Good 4.0 /5 Reviews Call BookMore Details
Courtyard by Marriott Houston Medical Center/NRG Park - Houston Houston Medical Center 7702 Main St., Houston, TX 77030
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~3.47 miles west of 77221
  • Affordable Suburban property
  • 197 rooms in property
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From$69
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Sonder Lofts at Ballpark : 610 St. Emanuel St. Houston Tx 77003 610 St. Emanuel St. Houston Tx 77003, Houston, TX 77003
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~3.47 miles north of 77221
  • Affordable Downtown property
  • Gym / Fitness Center Available
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From$100
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The Reside 7755 South Main St., Houston, TX 77054
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~3.50 miles west of 77221
  • 3-star Downtown hotel
  • Check-in time: 2:00PM
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From$55
Very Good 4.0 /5 Read Reviews Call BookMore Details
Holiday Inn Houston S Nrg Area Medical Center by IHG 8111 Kirby Dr., Houston, TX 77054
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~3.50 miles west of 77221
  • 3-star Suburban hotel
  • Hotel has 238 rooms
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From$126
Average 3.5 /5 Hotel Reviews Call BookMore Details
Four Seasons Hotel Houston - Houston 1300 Lamar St., Houston, TX 77010
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~3.51 miles north of 77221
  • Luxurious Five Star Downtown hotel
  • Hotel has 20 floors
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From$275
Very Good 4.0 /5 Review Score Call BookMore Details
Extended Stay America Suites Houston Med Ctr NRG Park Kirby : 1303 La Concha Ln 1303 La Concha Ln, Houston, TX 77054
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~3.52 miles west of 77221
  • Low priced Convention Center hotel
  • Complimentary breakfast is offered
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From$41
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Courtyard Houston Medical Center / Nrg Park 7702 Main St., Houston, TX 77030
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~3.55 miles west of 77221
  • 3 star Downtown hotel
  • 3 meeting rooms in property
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From$80
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Bayou City Event Center - Houston 9401 Knight Rd., Houston, TX 77045
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~3.55 miles southwest of 77221
  • Low Cost hotel
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From$60
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Residence Inn Houston Medical Center / Nrg Park in Houston 7807 Kirby Dr., Houston, TX 77030
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~3.56 miles west of 77221
  • 3-star Downtown hotel
  • Check in: 4:00 PM
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From$109
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Next: Show All Available 77221 Hotels with Pricing

Graph: Upcoming 20 Days of Houston Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Houston, TX discounts available. The chart reflects the cheapest Houston hotel for each day and each star rating category.

FAQs about hotels near 77221

What are the most favored hotels near 77221?

Home2 Suites, Hotel Zaza Houston Museum District and Houston Marriott Medical Center are the best rated hotels based on customer reviews in the last 365 days.

What are the most luxurious hotels near 77221?

Four Seasons Hotel Houston, Cliù Luxury Boutique Condo Hotel and Hilton University of Houston are the top 3 luxury hotels near 77221.

What hotels are closest to the area of 77221?

Cliù Luxury Boutique Condo Hotel, Extended Stay America Suites Houston Med Ctr Greenway Plaza, and Summit Inn - Houston Medical Center are the properties closest to 77221.

How much does a cheap hotel near 77221 cost per night?

In the last year, a 2 star hotel near 77221 can be as cheap as $63.37 per night. (based on HotelPlanner prices)

How much does a 3 star hotel near 77221 cost per night?

In the last year, the average 3 star hotel near 77221 has been $85.49 per night. (based on HotelPlanner prices)

How much does a 4-5 star hotel near 77221 cost?

In the last year, the average 4 star hotel near 77221 has been $111.54 per night. (based on HotelPlanner prices)

What are the best independent hotels near 77221?

Hotel Zaza Houston Museum District, Scott Inn Suites Downtown Houston and Blossom Houston Medical Center are the best rated independent hotels (not part of a big brand).

What are the most popular Marriott hotels near 77221?

Houston Marriott Medical Center, The Westin Hou Medical Center and Marriott Marquis Houston are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the best IHG hotels near 77221?

Holiday Inn Houston S Nrg Area Medical Center by IHG, Holiday Inn Houston Downtown by IHG and InterContinental Houston by IHG are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

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