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77221 Hotels/Motels & Accommodations

Cliù Houston - Houston
+1-888-389-4121
1715 Moritz Dr., Houston, TX 77055 ~1.14 miles northwest of 77221
  • High-end Downtown hotel
  • 8 suites in property
From$100
Average 3.0 /5 Latest Reviews Call BookMore Details
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Extended Stay America Suites Houston Med Ctr Greenway Plaza
+1-888-675-2083
2330 Southwest Frwy, Houston, TX 77098 ~1.17 miles west of 77221
  • 2-star Downtown hotel
  • 3 floors in hotel
From$61
Average 3.0 /5 Latest Reviews Call BookMore Details
Summit Inn
+1-800-716-8490
3138 Old Spanish Trail, Houston, TX 77054 ~1.37 miles west of 77221
  • Economy hotel
  • Check in: 11:00
From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
Hilton University of Houston - Houston
+1-800-805-5223
4800 Calhoun Rd., Houston, TX 77004 ~1.39 miles northeast of 77221
  • Four star Downtown hotel
  • 86 sleeping rooms in hotel
From$91
Very Good 4.0 /5 Guest Reviews Call BookMore Details
MainStay Suites Texas Medical Center/Reliant Park
+1-888-965-1860
3134 Old Spanish Trail, Houston, TX 77054 ~1.41 miles west of 77221
  • Economical Convention Center hotel
  • Check-in time: 11:00
From$60
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Americas Best Value Inn Medical Center Downtown : 2419 Riverside Dr.
+1-888-788-5576
2419 Riverside Dr., Houston, TX 77004 ~1.65 miles northwest of 77221
  • Economy property
  • Hotel has 40 rooms
From$60
Very Good 4.0 /5 Read Reviews Call BookMore Details
Home2 Suites
+1-888-897-9207
6840 Almeda Rd., Houston, TX 77030 ~1.82 miles west of 77221
  • 3 star Suburban hotel
  • Gym is available on property
From$99
Excellent 5.0 /5 Reviews Call BookMore Details
Medical District
+1-888-311-4278
2700 Old Spanish Trail, Houston, TX 77021 ~1.92 miles west of 77221
  • 4 star hotel
From$75
Average 3.0 /5 Hotel Reviews Call BookMore Details
Sonder The Hampstead
+1-888-469-4795
1508 Blodgett, Houston, TX 77004 ~2.33 miles northwest of 77221
  • Midscale Downtown property
  • 36 suites in hotel
From$80
Average 3.0 /5 Latest Reviews Call BookMore Details
Scott Inn Suites Downtown Houston - Houston
+1-888-734-9421
1933 Scott St., Houston, TX 77003 ~2.34 miles north of 77221
  • 3-star property
  • Check-in: 15:00
From$90
Very Good 4.0 /5 Read Reviews Call BookMore Details
Best Way Inn Houston - Medical Center : 3100 Holmes Rd.
+1-888-841-5292
3100 Holmes Rd., Houston, TX 77051 ~2.49 miles southwest of 77221
  • 2 star property
From$60
Average 3.0 /5 Recent Reviews Call BookMore Details
Extended Stay America Suites Houston Med Ctr Braeswood Bl - Houston
+1-888-455-5160
1301 Braeswood Blvd., Houston, TX 77030 ~2.52 miles west of 77221
  • Midscale Convention Center property
  • Free complimentary breakfast
From$64
Average 3.0 /5 Guest Reviews Call BookMore Details
Hotel Zaza Houston Museum District
+1-888-965-8297
5701 Main St., Houston, TX 77005 ~2.57 miles northwest of 77221
  • High-end Downtown hotel
  • Fitness + Health Center
From$159
Very Good 4.5 /5 Hotel Reviews Call BookMore Details
Blossom Houston Medical Center
+1-888-906-6358
7114 Bertner Ave., Houston, TX 77030 ~2.68 miles west of 77221
  • 3-star hotel
  • 230 rooms in property
From$90
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Blossom Hotel Houston - Houston
+1-888-749-6785
7118 Bertner Ave., Houston, TX 77030 ~2.69 miles west of 77221
  • Expensive Convention Center hotel
  • Hotel has 6 meeting rooms
From$130
Average 3.0 /5 Guest Reviews Call BookMore Details
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Days Inn Univ. of Houston / Downtown : 6190 Gulf Fwy
+1-888-878-9982
6190 Gulf Fwy, Houston, TX 77023 ~2.73 miles east of 77221
  • 3 star Downtown hotel
  • 52 sleeping rooms in hotel
From$55
Average 3.0 /5 Read Reviews Call BookMore Details
Lexington Hotel Houston Medical Center : 1025 Swanson St.
+1-888-389-4485
1025 Swanson St., Houston, TX 77030 ~2.78 miles west of 77221
  • Two star Downtown hotel
  • Fitness / Gym is on-site
From$60
Average 3.5 /5 Review Score Call BookMore Details
Hyatt Place
+1-888-389-4121
7329a Fannin St., Houston, TX 77030 ~2.79 miles west of 77221
  • 3 star hotel
From$80
Average 3.0 /5 Latest Reviews Call BookMore Details
Hyatt House West Medical Center
+1-888-675-2083
7329 Fannin St., Houston, TX 77030 ~2.79 miles west of 77221
  • Three Star property
From$80
Average 3.0 /5 Latest Reviews Call BookMore Details
Houston Marriott Medical Center/Museum District
+1-800-716-8490
6580 Fannin St., Houston, TX 77030 ~2.80 miles west of 77221
  • Four-star Downtown hotel
  • 14 meeting rooms in hotel
From$75
Very Good 4.5 /5 Recent Reviews Call BookMore Details
The Westin Hou Medical Center : 1709 Dryden Rd.
+1-800-805-5223
1709 Dryden Rd., Houston, TX 77030 ~2.81 miles west of 77221
  • 3-star hotel
  • Check-in: 15:00
From$90
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Sonder at Mid Main
+1-888-965-1860
3550 Main St., Houston, TX 77002 ~2.87 miles northwest of 77221
  • 3 star Downtown hotel
  • 12 suites in hotel
From$75
Average 3.0 /5 Reviews Call BookMore Details
Hampton Inn & Suites Houston Medical Center Nrg Park
+1-888-788-5576
1715 Old Spanish Trail, Houston, TX 77054 ~2.92 miles west of 77221
  • 3-star Convention Center property
  • 37 suites in property
From$69
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Hilton Houston Plaza / Medical Center - Houston
+1-888-897-9207
6633 Travis, Houston, TX 77030 ~2.93 miles west of 77221
  • 3-star Downtown property
  • Hotel has 106 suites
From$102
Very Good 4.0 /5 Reviews Call BookMore Details
SureStay Plus Hotel by Best Western Houston Medical Center : 6700 Main St.
+1-888-311-4278
6700 Main St., Houston, TX 77030 ~2.94 miles west of 77221
  • 3 star Downtown hotel
  • Hotel has 2 meeting rooms
From$57
Average 3.5 /5 Read Reviews Call BookMore Details
InterContinental Houston Medical Center, an IHG Hotel
+1-888-469-4795
6750 Main St., Houston, TX 77030 ~2.98 miles west of 77221
  • Four star Downtown property
  • Hotel has 37 suites
From$109
Very Good 4.0 /5 Read Reviews Call BookMore Details
Doubletree by Hilton Houston Medical Center Hotel & Suites
+1-888-734-9421
6800 Main St., Houston, TX 77030 ~3.01 miles west of 77221
  • Midscale Downtown property
  • Hotel has 40 rooms
From$80
Average 3.0 /5 Read Reviews Call BookMore Details
Extended Stay America - Houston - Med Ctr-NRG Park-Fannin : 7979 Fannin
+1-888-841-5292
7979 Fannin, Houston, TX 77054 ~3.02 miles west of 77221
  • Inexpensive Convention Center property
  • 12 suites in property
Holiday Inn Express Hotel & Suites Houston-Downtown Conv Ctr, an
+1-888-455-5160
1810 Bell St., Houston, TX 77003 ~3.11 miles north of 77221
  • Midscale Downtown hotel
  • Hotel has 22 suites
From$108
Very Good 4.0 /5 Reviews Call BookMore Details
Whyhotel Houston Downtown - Houston
+1-888-965-8297
1515 Austin St., Houston, TX 77002 ~3.33 miles north of 77221
  • 3 star property
  • 103 rooms in hotel
From$90
Very Good 4.0 /5 Review Score Call BookMore Details
Springhill Suites by Marriott
+1-888-906-6358
1400 Old Spanish Trail, Houston, TX 77054 ~3.36 miles west of 77221
  • Three Star Downtown hotel
  • 7 floors in hotel
From$119
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Athens Hotel Suites in Houston
+1-888-749-6785
1308 Clay St., Houston, TX 77002 ~3.39 miles north of 77221
  • 3-star Downtown property
  • Check-in time: 3PM
From$89
Average 3.0 /5 Guest Reviews Call BookMore Details
La Colombe D Or Hotel
+1-888-878-9982
3410 Montrose Blvd., Houston, TX 77006 ~3.41 miles northwest of 77221
  • 3-star hotel
  • Check in time: 16:00
From$90
Average 3.0 /5 Latest Reviews Call BookMore Details
Embassy Suites Houston Downtown in Houston
+1-888-389-4485
1515 Dallas, Houston, TX 77010 ~3.43 miles north of 77221
  • Affordable Downtown hotel
  • Check in: 3:00PM
From$135
Very Good 4.0 /5 Review Score Call BookMore Details
Sonder Midtown : 306 Mcgowen St.
+1-888-389-4121
306 Mcgowen St., Houston, TX 77006 ~3.44 miles northwest of 77221
  • 3 star Downtown property
  • 11 suites in hotel
From$75
Average 3.0 /5 Read Reviews Call BookMore Details
Holiday Inn Houston Downtown, an IHG Hotel - Houston
+1-888-675-2083
1616 Main St., Houston, TX 77002 ~3.46 miles north of 77221
  • 3 star Downtown property
  • Hotel has 16 floors
Marriott Marquis Houston
+1-800-716-8490
1777 Walker St., Houston, TX 77010 ~3.47 miles north of 77221
  • 4-star property
  • Fitness / Gym is on-site
From$375
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Sonder Lofts at Ballpark
+1-800-805-5223
610 St. Emanuel St. Houston Tx 77003, Houston, TX 77003 ~3.48 miles north of 77221
  • Affordable Downtown property
  • 6 floors in property
From$100
Average 3.0 /5 Latest Reviews Call BookMore Details
The Reside - Houston
+1-888-965-1860
7755 South Main St., Houston, TX 77054 ~3.51 miles west of 77221
  • 3 star Downtown property
  • 3 floors in property
From$55
Very Good 4.0 /5 Read Reviews Call BookMore Details
Holiday Inn Houston S - Nrg Area - Medical Center, an IHG Hotel
+1-888-788-5576
8111 Kirby Dr., Houston, TX 77054 ~3.51 miles west of 77221
  • Mid-scale Suburban hotel
  • 238 rooms in property
From$126
Average 3.5 /5 Reviews Call BookMore Details
Four Seasons Hotel Houston
+1-888-897-9207
1300 Lamar St., Houston, TX 77010 ~3.51 miles north of 77221
  • Luxurious Five Star Downtown hotel
  • Check-in time: 3:00 p.m.
From$275
Very Good 4.0 /5 Review Score Call BookMore Details
Extended Stay America Suites Houston Med Ctr NRG Park Kirby
+1-888-311-4278
1303 La Concha Ln, Houston, TX 77054 ~3.52 miles west of 77221
  • Cheap Convention Center property
  • Check in time: 3pm
From$41
Average 3.0 /5 Recent Reviews Call BookMore Details
Courtyard by Marriott Houston Medical Center/NRG Park
+1-888-469-4795
7702 Main St., Houston, TX 77030 ~3.55 miles west of 77221
  • Midscale Downtown hotel
  • Fitness center on property
From$80
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Bayou City Event Center
+1-888-734-9421
9401 Knight Rd., Houston, TX 77045 ~3.56 miles southwest of 77221
  • Economy hotel
From$60
Average 3.0 /5 Hotel Reviews Call BookMore Details
Residence Inn Houston Medical Center / Nrg Park : 7807 Kirby Dr.
+1-888-841-5292
7807 Kirby Dr., Houston, TX 77030 ~3.56 miles west of 77221
  • 3-star Downtown property
  • Gym is available on property
From$109
Very Good 4.0 /5 Read Reviews Call BookMore Details
Moody Manor
+1-888-455-5160
7706 Main St., Houston, TX 77030 ~3.58 miles west of 77221
  • 3-star Downtown hotel
  • 197 suites in hotel
From$69
Average 3.5 /5 Read Reviews Call BookMore Details
The Laura Hotel, Houston Downtown, Autograph Collection - Houston
+1-888-965-8297
1070 Dallas St., Houston, TX 77002 ~3.58 miles north of 77221
  • Luxury 5-star Downtown property
  • 5 conference rooms in property
From$70
Very Good 4.0 /5 Read Reviews Call BookMore Details
Hampton Inn Houston Downtown in Houston
+1-888-906-6358
710 Crawford St., Houston, TX 77002 ~3.58 miles north of 77221
  • Mid-scale Convention Center hotel
  • Hotel has 127 suites
From$89
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Oakwood at Midtown Arbor Place - Houston
+1-888-749-6785
10 Oak Court, Houston, TX 77006 ~3.58 miles north of 77221
  • 3 star hotel
  • Check in time: 15:30
From$90
Average 3.0 /5 Latest Reviews Call BookMore Details
Rodeway Inn & Suites Houston Medical Center : 6712 Morningside Dr.
+1-888-878-9982
6712 Morningside Dr., Houston, TX 77030 ~3.60 miles west of 77221
  • 2 star Downtown hotel
  • 33 sleeping rooms in hotel
From$60
Average 3.0 /5 Guest Reviews Call BookMore Details

Next: Show All Available 77221 Hotels with Pricing

Graph: Upcoming 20 Days of Houston Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Houston, TX discounts available. The chart reflects the cheapest Houston hotel for each day and each star rating category.

FAQs about hotels near 77221

What are the most favored hotels near 77221?

Home2 Suites, Hotel Zaza Houston Museum District and Houston Marriott Medical Center are the best rated hotels based on customer reviews in the last 365 days.

What are the most luxurious hotels near 77221?

Four Seasons Hotel Houston, The Laura Hotel, Houston Downtown, Autograph Collection and Cliù Houston are the top 3 luxury hotels near 77221.

What hotels are closest to the area of 77221?

Cliù Houston, Extended Stay America Suites Houston Med Ctr Greenway Plaza, and Summit Inn are the properties closest to 77221.

How much does a cheap hotel near 77221 cost per night?

In the last year, a 2 star hotel near 77221 can be as cheap as $63.37 per night. (based on HotelPlanner prices)

How much does a 3 star hotel near 77221 cost per night?

In the last year, the average 3 star hotel near 77221 has been $85.49 per night. (based on HotelPlanner prices)

How much does a 4-5 star hotel near 77221 cost?

In the last year, the average 4 star hotel near 77221 has been $111.54 per night. (based on HotelPlanner prices)

What are the best independent hotels near 77221?

Hotel Zaza Houston Museum District, Scott Inn Suites Downtown Houston and Blossom Houston Medical Center are the best rated independent hotels (not part of a big brand).

What are the most popular Marriott hotels near 77221?

Houston Marriott Medical Center, The Westin Hou Medical Center and Springhill Suites by Marriott are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the best Choice Hotels branded hotels near 77221?

MainStay Suites Texas Medical Center and Rodeway Inn & Suites Houston Medical Center are the best rated Choice Hotels branded hotels (based on HotelPlanner reviews score).

What are the most popular IHG hotels near 77221?

InterContinental Houston Medical Center, an IHG Hotel, Holiday Inn Express Hotel & Suites Houston-Downtown Conv Ctr, an and Holiday Inn Houston S - Nrg Area - Medical Center, an IHG Hotel are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

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