Hotels in 77221 - Houston TX

Only hotels in 77221 zip code are listed below. Search for cheap and discount hotel rates in Houston, TX for your upcoming leisure or conference / group travel. We list the best 77221 hotels and motels so you can review the Houston hotel list below to find the perfect lodging. Hotels in Harris county and area code 713 are also listed.


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77221 Hotels/Motels & Accommodations

Photo of Extended Stay America Houston Greenway Plaza Extended Stay America Houston Greenway Plaza in Houston
+1-800-230-4134Check Rates
2330 SW Frwy, Houston, TX 77098
  • 3.5/5, Average Read Reviews
  • Two-star Downtown property
  • Fitness center on property
~1.17 Miles from 77221
Photo of Hilton University of Houston Hilton University of Houston in Houston
+1-800-997-5148Check Rates
4800 Calhoun Rd., Houston, TX 77004
  • 4.0/5, Very Good Hotel Reviews
  • Four star Downtown property
  • Fitness / Gym is on-site
~1.41 Miles from 77221
Exterior of Mainstay Suites Mainstay Suites - Houston
+1-800-997-5149Check Rates
3134 Old Spanish Trail, Houston, TX 77054
  • 4.0/5, Very Good Recent Reviews
  • Cheap Convention Center hotel
  • 4 floors in hotel
~1.49 Miles from 77221
Extended Stay Deluxe Houston Medical Center
+1-800-230-4134Check Rates
1301 Braeswood Blvd., Houston, TX 77030
  • 3.0/5, Average Latest Reviews
  • Three Star Convention Center property
  • 130 rooms in property
~2.52 Miles from 77221
Exterior of Hotel Zaza Houston Hotel Zaza Houston : 5701 Main St.
+1-800-997-5148Check Rates
5701 Main St., Houston, TX 77005
  • 4.5/5, Very Good Recent Reviews
  • Four-star Downtown hotel
  • Hotel has 315 rooms
~2.57 Miles from 77221
Exterior of Lexington Hotel Houston Medical Center Lexington Hotel Houston Medical Center in Houston
+1-800-997-5149Check Rates
1025 Swanson St., Houston, TX 77030
  • Three Star Downtown property
  • Hotel has 38 rooms
~2.75 Miles from 77221
Photo of Hotel Icon Hotel Icon - Houston
+1-800-230-4134Check Rates
220 Main St., Houston, TX 77002
  • Four-star Downtown property
  • 6 meeting rooms in hotel
~2.79 Miles from 77221
Image of Houston Marriott Medical Center Houston Marriott Medical Center - Houston
+1-800-997-5148Check Rates
6580 Fannin St., Houston, TX 77030
  • Four-star Downtown property
  • 14 meeting rooms in property
~2.80 Miles from 77221
Hampton Inn & Suites Houston Medical Center
+1-800-997-5149Check Rates
1715 Old Spanish Trail, Houston, TX 77054
  • 4.5/5, Very Good Reviews
  • 3-star Convention Center property
  • Check-in time: 3:00PM
~2.92 Miles from 77221
Hilton Houston Plaza Medical Center
+1-800-230-4134Check Rates
6633 Travis, Houston, TX 77030
  • 4.0/5, Very Good Reviews
  • Mid-scale Downtown hotel
  • 9 meeting rooms in property
~2.93 Miles from 77221
Robin's Nest Bed & Breakfast Inn : 4104 Greeley St.
+1-800-997-5148Check Rates
4104 Greeley St., Houston, TX 77006
  • 3 star Downtown property
  • Check-in: after 1 pm
~2.99 Miles from 77221
Wyndham Houston Medical Center Hotel & Suite in Houston
+1-800-997-5149Check Rates
6800 Main St., Houston, TX 77030
  • 4.0/5, Very Good Review Score
  • Three Star Downtown property
  • Fitness + Health Center
~2.99 Miles from 77221
Holiday Inn Express & Suites Downtown : 1810 Bell St.
+1-800-230-4134Check Rates
1810 Bell St., Houston, TX 77003
  • 4.0/5, Very Good Guest Reviews
  • 3-star Downtown property
  • Check in time: 3:00pm
~3.14 Miles from 77221
Hilton Americas Houston - Houston
+1-800-997-5148Check Rates
1600 Lamar, Houston, TX 77010
  • 4.5/5, Very Good Reviews
  • High-end Downtown hotel
  • 1200 rooms in property
~3.32 Miles from 77221
Springhill Suites by Marriott Houston Nrg Park : 1400 Old Spanish Trail
+1-800-997-5149Check Rates
1400 Old Spanish Trail, Houston, TX 77054
  • Mid-scale Downtown hotel
  • Hotel has 190 rooms
~3.33 Miles from 77221
Athens Hotel
+1-800-230-4134Check Rates
1308 Clay St., Houston, TX 77002
  • 3.0/5, Average Review Score
  • Low Cost Downtown property
  • Check-in time: 2PM
~3.41 Miles from 77221
Courtyard by Marriott Houston Medical Center
+1-800-997-5148Check Rates
Houston Medical Center 7702 Main St., Houston, TX 77030
  • 4.0/5, Very Good Hotel Reviews
  • Midscale Suburban hotel
  • 197 rooms in property
~3.48 Miles from 77221
Holiday Inn Houston N R G Park Area
+1-800-997-5149Check Rates
8111 Kirby Dr., Houston, TX 77054
  • 3.5/5, Average Reviews
  • 3 star Suburban hotel
  • Gym / Fitness Center Available
~3.51 Miles from 77221
Extended Stay America Houston Reliant Pk. La Conch - Houston
+1-800-230-4134Check Rates
1303 La Concha Ln, Houston, TX 77054
  • 3.0/5, Average Recent Reviews
  • Mid-scale Convention Center hotel
  • Check-in: 3pm
~3.52 Miles from 77221
Four Seasons Hotel Houston - Houston
+1-800-997-5148Check Rates
1300 Lamar St., Houston, TX 77010
  • 4.5/5, Very Good Guest Reviews
  • Luxurious Five Star Downtown hotel
  • 14 conference rooms in property
~3.52 Miles from 77221
Moody Manor at the Houston Medical Center - Houston
+1-800-997-5149Check Rates
7706 South Main, Houston, TX 77030
  • Cheap Downtown property
  • 14 suites in hotel
~3.53 Miles from 77221
Residence Inn by Marriott Medical Center / Reliant
+1-800-230-4134Check Rates
7710 Main St., Houston, TX 77030
  • 3.5/5, Average Latest Reviews
  • Midscale Highway property
  • Check-in: 3:00pm
~3.60 Miles from 77221
Crowne Plaza Houston Downtown - Houston
+1-800-997-5148Check Rates
1700 Smith St., Houston, TX 77002
  • High-end Downtown property
  • Check-in: 12 Noon
~3.62 Miles from 77221
Rodeway Inn Suites
+1-800-997-5149Check Rates
6712 Morningside Dr., Houston, TX 77030
  • Two-star Downtown property
  • Complimentary breakfast is offered
~3.63 Miles from 77221
Residence Inn Houston Downtown
+1-800-230-4134Check Rates
904 Dallas St., Houston, TX 77002
  • 4.0/5, Very Good Read Reviews
  • Mid-scale Downtown property
  • 171 sleeping rooms in hotel
~3.64 Miles from 77221
Courtyard Houston Downtown - Houston
+1-800-997-5148Check Rates
916 Dallas St., Houston, TX 77002
  • 3.5/5, Average Recent Reviews
  • 3-star Downtown property
  • 191 rooms in hotel
~3.64 Miles from 77221
The Westin Houston Downtown
+1-800-997-5149Check Rates
1520 Texas Ave., Houston, TX 77002
  • 4.0/5, Very Good Hotel Reviews
  • Four-star Downtown property
  • Check in: 3:00 PM
~3.71 Miles from 77221
Holiday Inn Express Suites Medical Center - Houston
+1-800-230-4134Check Rates
8080 South Main St., Houston, TX 77025
  • 4.0/5, Very Good Reviews
  • Three Star Downtown hotel
  • 3 floors in property
~3.72 Miles from 77221
Hyatt Regency Houston in Houston
+1-800-997-5148Check Rates
1200 Louisiana St., Houston, TX 77002
  • 4.0/5, Very Good Reviews
  • High end Downtown property
  • 30 floors in hotel
~3.78 Miles from 77221
Comfort Suites - Houston
+1-800-997-5149Check Rates
1055 Mcnee Rd., Houston, TX 77054
  • 3.5/5, Average Recent Reviews
  • Low priced Convention Center property
  • Hotel has 50 suites
~3.82 Miles from 77221
JW Marriott Houston Downtown
+1-800-230-4134Check Rates
806 Main, Houston, TX 77002
  • Luxurious Five Star hotel
~3.82 Miles from 77221
Magnolia Hotel
+1-800-997-5148Check Rates
1100 Texas Ave., Houston, TX 77002
  • 4.5/5, Very Good Read Reviews
  • Expensive Downtown hotel
  • Fitness / Gym is on-site
~3.84 Miles from 77221
Crowne Plaza Houston Near Reliant Medical
+1-800-997-5149Check Rates
8686 Kirby Dr., Houston, TX 77054
  • Affordable Convention Center property
  • 652 rooms in property
~3.86 Miles from 77221
Doubletree Houston Downtown in Houston
+1-800-230-4134Check Rates
400 Dallas St., Houston, TX 77002
  • 4.0/5, Very Good Guest Reviews
  • 3-star Downtown property
  • Check in time: 3:00pm
~3.89 Miles from 77221
The Sam Houston Hotel : 1117 Prairie St.
+1-800-997-5148Check Rates
1117 Prairie St., Houston, TX 77002
  • 4.0/5, Very Good Guest Reviews
  • Four star Downtown property
  • 100 sleeping rooms in hotel
~3.91 Miles from 77221
Best Western Downtown Inn & Suites - Houston
+1-800-997-5149Check Rates
915 West Dallas, Houston, TX 77019
  • 4.5/5, Very Good Guest Reviews
  • 3 star Downtown property
  • 76 rooms in property
~3.97 Miles from 77221
The Quality Inn & Suites Reliant Park in Houston
+1-800-230-4134Check Rates
2364 South Loop West, Houston, TX 77054
  • 3.5/5, Average Reviews
  • Mid-scale Convention Center property
  • 2 floors in hotel
~3.99 Miles from 77221
The Lancaster Hotel Houston
+1-800-997-5148Check Rates
701 Texas Ave., Houston, TX 77002
  • Four-star Downtown property
  • Check in time: 3:00 pm
~4.04 Miles from 77221
Crowne Plaza Houston River Oaks
+1-800-997-5149Check Rates
2712 Southwest Fwy, Houston, TX 77098
  • 4.5/5, Very Good Recent Reviews
  • 4 star Downtown hotel
  • Gym is available on property
~4.38 Miles from 77221
Residence Inn in Houston
+1-800-230-4134Check Rates
2939 Westpark Dr., Houston, TX 77005
  • 4.0/5, Very Good Read Reviews
  • 3-star Downtown hotel
  • Check-in time: 03:00pm
~4.48 Miles from 77221
Courtyard by Marriott Houston West University : 2929 Westpark Dr.
+1-800-997-5148Check Rates
2929 Westpark Dr., Houston, TX 77005
  • 4.0/5, Very Good Read Reviews
  • Midscale Suburban property
  • Gym / Fitness Center Available
~4.49 Miles from 77221
Four Points by Sheraton Houston Greenaway Plaza in Houston
+1-800-997-5149Check Rates
2828 Southwest Freeway, Houston, TX 77098
  • Mid-scale Downtown hotel
  • 216 rooms in property
~4.50 Miles from 77221
Greenway Inn & Suites
+1-800-230-4134Check Rates
2929 Southwest Freeway, Houston, TX 77098
  • 1.5/5, Terrible Recent Reviews
  • Economy Suburban hotel
  • 160 rooms in hotel
~4.50 Miles from 77221
La Quinta Inn Reliant / Medical Center - Houston
+1-800-997-5148Check Rates
9911 Buffalo Speedway, Houston, TX 77054
  • 3.0/5, Average Recent Reviews
  • Low Cost Downtown hotel
  • 3 floors in hotel
~4.54 Miles from 77221
Americas Best Value Inn - Houston
+1-800-997-5149Check Rates
9604 South Main, Houston, TX 77025
  • 3.5/5, Average Reviews
  • Economy Convention Center hotel
  • Free comp. breakfast
~4.68 Miles from 77221
Candlewood Suites Extended Stay in Houston
+1-800-230-4134Check Rates
10025 South Main St., Houston, TX 77025
  • Three Star Highway property
  • Access to gym on-site
~4.70 Miles from 77221
Executive Inn & Suites
+1-800-997-5148Check Rates
6711 Telephone Rd., Houston, TX 77061 ~4.75 Miles from 77221
Carefree Inn at the Medical Center in Houston
+1-800-997-5149Check Rates
10015 South Main St., Houston, TX 77025
  • 4.0/5, Very Good Latest Reviews
  • 2 star Downtown hotel
  • Check-in time: 2:00 PM
~4.76 Miles from 77221
Motel 6 Houston Reliant Park #1126
+1-800-230-4134Check Rates
3223 South Loop West, Houston, TX 77025
  • Two-star hotel
  • 3 floors in hotel
~4.77 Miles from 77221
Doubletree by Hilton Houston Greenway Plaza : 6 Greenway Plaza
+1-800-997-5148Check Rates
6 Greenway Plaza, Houston, TX 77046
  • High end Highway hotel
  • 388 rooms in hotel
~5.01 Miles from 77221



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