Hotels in 77221 - Houston TX

Only hotels in 77221 zip code are listed below. Search for cheap and discount hotel rates in Houston, TX for your upcoming leisure or conference / group travel. We list the best 77221 hotels and motels so you can review the Houston hotel list below to find the perfect lodging. Hotels in Harris county and area code 713 are also listed.

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77221 Hotels & Accommodations

Cliù Luxury Boutique Condo Hotel 3144 Southmore Blvd. Unit 10, Houston, TX 77004
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~1.13 miles northwest of 77221
  • High-end Downtown hotel
  • 16 sleeping rooms in hotel
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From$100
Average 3.0 /5 Reviews Call BookMore Details
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Extended Stay America Suites Houston Med Ctr Greenway Plaza 2330 Southwest Frwy, Houston, TX 77098
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~1.16 miles west of 77221
  • Two star Downtown hotel
  • 2 suites in property
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From$61
Average 3.0 /5 Reviews Call BookMore Details
Summit Inn - Houston Medical Center - Houston 3138 Old Spanish Trail, Houston, TX 77054
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~1.37 miles west of 77221
  • Low priced hotel
  • Check in: 11:00
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From$60
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Mainstay Suites Texas Medical Center / Reliant Park : 3134 Old Spanish Trail 3134 Old Spanish Trail, Houston, TX 77054
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~1.41 miles west of 77221
  • Cheap Convention Center property
  • Hotel has 89 rooms
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From$60
Very Good 4.0 /5 Review Score Call BookMore Details
Hilton University of Houston 4800 Calhoun Rd., Houston, TX 77004
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~1.54 miles northeast of 77221
  • 4-star Downtown property
  • 86 sleeping rooms in hotel
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From$125
Average 3.0 /5 Guest Reviews Call BookMore Details
Americas Best Value Inn Medical Center Downtown : 2419 Riverside Dr. 2419 Riverside Dr., Houston, TX 77004
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~1.64 miles northwest of 77221
  • Low Cost hotel
  • Check-in: 15:00
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From$60
Very Good 4.0 /5 Reviews Call BookMore Details
Home2 Suites 6840 Almeda Rd., Houston, TX 77030
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~1.81 miles west of 77221
  • Affordable Suburban hotel
  • Fitness + Health Center
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From$99
Excellent 5.0 /5 Hotel Reviews Call BookMore Details
Hilton Garden Inn 6840b Almeda Rd., Houston, TX 77030
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~1.81 miles west of 77221
  • Mid-scale Suburban property
  • Check in: 3:00 PM
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From$109
Average 3.0 /5 Recent Reviews Call BookMore Details
Hilton Garden 6840 B Almeda Rd., Houston, TX 77030
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~1.82 miles west of 77221
  • Affordable property
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From$80
Average 3.0 /5 Recent Reviews Call BookMore Details
Medical District in Houston 2700 Old Spanish Trail, Houston, TX 77021
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~1.92 miles west of 77221
  • High end hotel
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From$75
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Sonder The Hampstead : 1508 Blodgett 1508 Blodgett, Houston, TX 77004
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~2.32 miles northwest of 77221
  • Midscale Downtown hotel
  • 36 suites in property
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From$80
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Scott Inn Suites Downtown Houston : 1933 Scott St. 1933 Scott St., Houston, TX 77003
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~2.34 miles north of 77221
  • 3-star hotel
  • 18 rooms in property
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From$90
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Best Way Inn Houston - Medical Center in Houston 3100 Holmes Rd., Houston, TX 77051
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~2.49 miles southwest of 77221
  • Low priced property
  • Hotel has 42 rooms
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From$60
Average 3.0 /5 Latest Reviews Call BookMore Details
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Extended Stay America Suites Houston Med Ctr Braeswood Bl 1301 Braeswood Blvd., Houston, TX 77030
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~2.52 miles west of 77221
  • 3 star Convention Center hotel
  • Gym is available on property
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From$64
Average 3.0 /5 Review Score Call BookMore Details
Hotel Zaza Houston Museum District 5701 Main St., Houston, TX 77005
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~2.57 miles northwest of 77221
  • Four star Downtown property
  • Fitness / Gym is on-site
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From$159
Very Good 4.5 /5 Review Score Call BookMore Details
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Blossom Houston Medical Center 7114 Bertner Ave., Houston, TX 77030
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~2.68 miles west of 77221
  • Affordable hotel
  • Check-in time: 16:00
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From$90
Very Good 4.0 /5 Reviews Call BookMore Details
Blossom Hotel Houston 7118 Bertner Ave., Houston, TX 77030
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~2.68 miles west of 77221
  • Expensive Convention Center hotel
  • 267 sleeping rooms in hotel
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From$169
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Days Inn & Suites by Wyndham Downtown / University of Houston : 6190 Gulf Freeway 6190 Gulf Freeway, Houston, TX 77023
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~2.72 miles east of 77221
  • Three Star Downtown property
  • Hotel has 52 rooms
More Photos Image of Days Inn & Suites by Wyndham Downtown / University of Houston
From$55
Average 3.0 /5 Hotel Reviews Call BookMore Details
Lexington Hotel Houston Medical Center : 1025 Swanson St. 1025 Swanson St., Houston, TX 77030
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~2.78 miles west of 77221
  • Cheap Downtown hotel
  • Free comp. breakfast
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From$60
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Hyatt Place - Houston 7329a Fannin St., Houston, TX 77030
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~2.78 miles west of 77221
  • Affordable hotel
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From$80
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Hyatt Place Hyatt House Houston Medical Center 7329 Fannin St., Houston, TX 77030
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~2.78 miles west of 77221
  • Three Star Suburban property
  • 14 floors in property
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From$99
Average 3.0 /5 Recent Reviews Call BookMore Details
Houston Marriott Medical Center/Museum District - Houston 6580 Fannin St., Houston, TX 77030
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~2.80 miles west of 77221
  • 4 star Downtown property
  • Gym / Fitness Center Available
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From$75
Very Good 4.5 /5 Read Reviews Call BookMore Details
The Westin Hou Medical Center 1709 Dryden Rd., Houston, TX 77030
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~2.81 miles west of 77221
  • Three Star hotel
  • Check in time: 15:00
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From$90
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Sonder at Mid Main - Houston 3550 Main St., Houston, TX 77002
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~2.86 miles northwest of 77221
  • Midscale Downtown hotel
  • Hotel has 12 suites
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From$75
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Hampton Inn & Suites Houston Medical Center Nrg Park : 1715 Old Spanish Trail 1715 Old Spanish Trail, Houston, TX 77054
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~2.91 miles west of 77221
  • Midscale Convention Center property
  • 5 floors in property
More Photos Exterior of Hampton Inn & Suites Houston Medical Center Nrg Park
From$69
Very Good 4.0 /5 Review Score Call BookMore Details
Houston Medical Center Hotel - Houston 6700 Main St., Houston, TX 77030
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~2.94 miles west of 77221
  • Affordable Downtown hotel
  • Complimentary breakfast is offered
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From$115
Average 3.5 /5 Review Score Call BookMore Details
InterContinental Houston by IHG 6750 Main St., Houston, TX 77030
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~2.98 miles west of 77221
  • High end Downtown hotel
  • Hotel has a green policy Learn more
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From$75
Average 3.0 /5 Review Score Call BookMore Details
Doubletree by Hilton Houston Medical Center Hotel & Suites - Houston 6800 Main St., Houston, TX 77030
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~3.01 miles west of 77221
  • Four star Downtown hotel
  • Hotel has an eco-friendly policy See more
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From$125
Average 3.0 /5 Hotel Reviews Call BookMore Details
Extended Stay America - Houston - Med Ctr-NRG Park-Fannin 7979 Fannin, Houston, TX 77054
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~3.01 miles west of 77221
  • Low Cost Convention Center hotel
  • 3 floors in property
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From$49
Poor 2.5 /5 Review Score Call BookMore Details
Holiday Inn Express Houston Downtown 1810 Bell St., Houston, TX 77003
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~3.10 miles north of 77221
  • Three Star Downtown property
  • Free breakfast available
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From$80
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Wanderstay Boutique Hotel 520 Sampson St., Houston, TX 77003
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~3.15 miles north of 77221
  • Four star property
  • Hotel has 2 suites
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From$125
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SpringHill Suites Houston Medical Center/NRG Park - Houston 1400 Old Spanish Trl, Houston, TX 77054
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~3.32 miles west of 77221
  • Three Star Downtown property
  • Fitness / Gym is on-site
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From$80
Average 3.0 /5 Hotel Reviews Call BookMore Details
Whyhotel Houston Downtown 1515 Austin St., Houston, TX 77002
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~3.33 miles north of 77221
  • 3 star property
  • 103 rooms in property
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From$90
Very Good 4.0 /5 Reviews Call BookMore Details
Athens Hotel Suites 1308 Clay St., Houston, TX 77002
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~3.39 miles north of 77221
  • 3-star Downtown property
  • Hotel has 21 rooms
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From$89
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La Colombe D Or Hotel in Houston 3410 Montrose Blvd., Houston, TX 77006
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~3.40 miles northwest of 77221
  • Midscale hotel
  • Hotel has 2 floors
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From$90
Average 3.0 /5 Recent Reviews Call BookMore Details
Hilton Americas Houston 1600 Lamar St., Houston, TX 77010
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~3.40 miles north of 77221
  • High-end Downtown property
  • Check in: 3:00 PM
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From$101
Very Good 4.5 /5 Read Reviews Call BookMore Details
Hotel Saint Augustine : 4110 Loretto Dr. 4110 Loretto Dr., Houston, TX 77006
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~3.41 miles northwest of 77221
  • Four star Downtown property
  • 71 rooms in hotel
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From$401
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Embassy Suites Houston Downtown 1515 Dallas, Houston, TX 77010
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~3.42 miles north of 77221
  • Three Star Downtown hotel
  • Hotel has 19 floors
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From$135
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Sonder Midtown : 306 Mcgowen St. 306 Mcgowen St., Houston, TX 77006
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~3.44 miles northwest of 77221
  • Affordable Downtown property
  • Gym is available on property
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From$75
Average 3.0 /5 Review Score Call BookMore Details
Holiday Inn Houston Downtown by IHG 1616 Main St., Houston, TX 77002
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~3.46 miles north of 77221
  • 3-star Downtown hotel
  • Check-in time: 3:00 PM
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From$79
Poor 2.0 /5 Reviews Call BookMore Details
Marriott Marquis Houston 1777 Walker St., Houston, TX 77010
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~3.46 miles north of 77221
  • High end hotel
  • 29 floors in property
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From$375
Very Good 4.0 /5 Reviews Call BookMore Details
Courtyard by Marriott Houston Medical Center/NRG Park Houston Medical Center 7702 Main St., Houston, TX 77030
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~3.47 miles west of 77221
  • Midscale Suburban property
  • 3 meeting rooms in property
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From$69
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Sonder Lofts at Ballpark : 610 St. Emanuel St. Houston Tx 77003 610 St. Emanuel St. Houston Tx 77003, Houston, TX 77003
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~3.47 miles north of 77221
  • 3 star Downtown hotel
  • 22 sleeping rooms in hotel
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From$100
Average 3.0 /5 Review Score Call BookMore Details
The Reside : 7755 South Main St. 7755 South Main St., Houston, TX 77054
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~3.50 miles west of 77221
  • Midscale Downtown property
  • Hotel has a green policy See policy
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From$55
Very Good 4.0 /5 Read Reviews Call BookMore Details
Holiday Inn Houston S - Nrg Area - Medical Center by IHG - Houston 8111 Kirby Dr., Houston, TX 77054
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~3.50 miles west of 77221
  • Mid-scale Suburban hotel
  • 238 rooms in hotel
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From$126
Average 3.5 /5 Latest Reviews Call BookMore Details
Four Seasons Hotel Houston - Houston 1300 Lamar St., Houston, TX 77010
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~3.51 miles north of 77221
  • Luxury 5 star Downtown hotel
  • Fitness center on property
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From$275
Very Good 4.0 /5 Reviews Call BookMore Details
Extended Stay America Suites Houston Med Ctr NRG Park Kirby : 1303 La Concha Ln 1303 La Concha Ln, Houston, TX 77054
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~3.52 miles west of 77221
  • Inexpensive Convention Center hotel
  • Complimentary breakfast is offered
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From$41
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Courtyard Houston Medical Center / Nrg Park : 7702 Main St. 7702 Main St., Houston, TX 77030
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~3.55 miles west of 77221
  • Three Star Downtown hotel
  • Hotel has 3 meeting rooms
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From$80
Average 3.0 /5 Recent Reviews Call BookMore Details
Bayou City Event Center - Houston 9401 Knight Rd., Houston, TX 77045
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~3.55 miles southwest of 77221
  • 2-star property
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From$60
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Residence Inn Houston Medical Center / Nrg Park 7807 Kirby Dr., Houston, TX 77030
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~3.56 miles west of 77221
  • 3-star Downtown property
  • 182 suites in property
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From$109
Very Good 4.0 /5 Hotel Reviews Call BookMore Details

Next: Show All Available 77221 Hotels with Pricing

Graph: Upcoming 20 Days of Houston Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Houston, TX discounts available. The chart reflects the cheapest Houston hotel for each day and each star rating category.

FAQs about hotels near 77221

What are the most favored hotels near 77221?

Home2 Suites, Hotel Zaza Houston Museum District and Houston Marriott Medical Center are the best rated hotels based on customer reviews in the last 365 days.

What are the most luxurious hotels near 77221?

Four Seasons Hotel Houston, Cliù Luxury Boutique Condo Hotel and Hilton University of Houston are the top 3 luxury hotels near 77221.

What hotels are closest to the area of 77221?

Cliù Luxury Boutique Condo Hotel, Extended Stay America Suites Houston Med Ctr Greenway Plaza, and Summit Inn - Houston Medical Center are the properties closest to 77221.

How much does a cheap hotel near 77221 cost per night?

In the last year, a 2 star hotel near 77221 can be as cheap as $63.37 per night. (based on HotelPlanner prices)

How much does a 3 star hotel near 77221 cost per night?

In the last year, the average 3 star hotel near 77221 has been $85.49 per night. (based on HotelPlanner prices)

How much does a 4-5 star hotel near 77221 cost?

In the last year, the average 4 star hotel near 77221 has been $111.54 per night. (based on HotelPlanner prices)

What are the best independent hotels near 77221?

Hotel Zaza Houston Museum District, Scott Inn Suites Downtown Houston and Blossom Houston Medical Center are the best rated independent hotels (not part of a big brand).

What are the most popular Marriott hotels near 77221?

Houston Marriott Medical Center, The Westin Hou Medical Center and Marriott Marquis Houston are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the best IHG hotels near 77221?

Holiday Inn Houston S - Nrg Area - Medical Center by IHG, Holiday Inn Houston Downtown by IHG and InterContinental Houston by IHG are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

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