Hotels in 77221 - Houston TX

Only hotels in 77221 zip code are listed below. Search for cheap and discount hotel rates in Houston, TX for your upcoming leisure or conference / group travel. We list the best 77221 hotels and motels so you can review the Houston hotel list below to find the perfect lodging. Hotels in Harris county and area code 713 are also listed.

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77221 Hotels/Motels & Accommodations

Cliù Luxury Boutique Condo Hotel in Houston 3144 Southmore Blvd. Unit 10, Houston, TX 77004
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~1.13 miles northwest of 77221
  • Four star Downtown hotel
  • 2 floors in property
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From$100
Average 3.0 /5 Latest Reviews Call BookMore Details
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Extended Stay America Suites Houston Med Ctr Greenway Plaza : 2330 Southwest Frwy 2330 Southwest Frwy, Houston, TX 77098
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~1.16 miles west of 77221
  • 2 star Downtown property
  • 3 floors in property
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From$61
Average 3.0 /5 Recent Reviews Call BookMore Details
Summit Inn - Houston Medical Center 3138 Old Spanish Trail, Houston, TX 77054
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~1.37 miles west of 77221
  • Economical property
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From$60
Average 3.0 /5 Review Score Call BookMore Details
Mainstay Suites Texas Medical Center / Reliant Park 3134 Old Spanish Trail, Houston, TX 77054
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~1.41 miles west of 77221
  • Low-priced Convention Center hotel
  • Fitness / Gym is on-site
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From$60
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Hilton University of Houston in Houston 4800 Calhoun Rd., Houston, TX 77004
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~1.54 miles northeast of 77221
  • 4 star Downtown hotel
  • 86 rooms in property
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From$125
Average 3.0 /5 Read Reviews Call BookMore Details
Americas Best Value Inn Medical Center Downtown in Houston 2419 Riverside Dr., Houston, TX 77004
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~1.64 miles northwest of 77221
  • Inexpensive property
  • Free breakfast
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From$60
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Home2 Suites : 6840 Almeda Rd. 6840 Almeda Rd., Houston, TX 77030
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~1.81 miles west of 77221
  • 3-star Suburban property
  • Hotel has 3 meeting rooms
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From$99
Excellent 5.0 /5 Read Reviews Call BookMore Details
Hilton Garden Inn 6840b Almeda Rd., Houston, TX 77030
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~1.81 miles west of 77221
  • Midscale Suburban hotel
  • Check in time: 3:00 PM
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From$109
Average 3.0 /5 Recent Reviews Call BookMore Details
Hilton Garden in Houston 6840 B Almeda Rd., Houston, TX 77030
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~1.82 miles west of 77221
  • Three Star property
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From$80
Average 3.0 /5 Reviews Call BookMore Details
Medical District - Houston 2700 Old Spanish Trail, Houston, TX 77021
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~1.92 miles west of 77221
  • High end property
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From$75
Average 3.0 /5 Guest Reviews Call BookMore Details
Sonder The Hampstead - Houston 1508 Blodgett, Houston, TX 77004
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~2.32 miles northwest of 77221
  • 3 star Downtown hotel
  • Check in: 4:00 PM
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From$80
Average 3.0 /5 Read Reviews Call BookMore Details
Scott Inn Suites Downtown Houston 1933 Scott St., Houston, TX 77003
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~2.34 miles north of 77221
  • 3 star hotel
  • 18 rooms in property
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From$90
Very Good 4.0 /5 Reviews Call BookMore Details
Best Way Inn Houston - Medical Center 3100 Holmes Rd., Houston, TX 77051
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~2.49 miles southwest of 77221
  • Economical hotel
  • 42 rooms in property
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From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
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Extended Stay America Suites Houston Med Ctr Braeswood Bl 1301 Braeswood Blvd., Houston, TX 77030
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~2.52 miles west of 77221
  • 3-star Convention Center property
  • 130 rooms in hotel
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From$64
Average 3.0 /5 Recent Reviews Call BookMore Details
Hotel Zaza Houston Museum District 5701 Main St., Houston, TX 77005
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~2.57 miles northwest of 77221
  • High-end Downtown property
  • Hotel has 75 suites
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From$159
Very Good 4.5 /5 Guest Reviews Call BookMore Details
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Blossom Houston Medical Center 7114 Bertner Ave., Houston, TX 77030
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~2.68 miles west of 77221
  • Midscale hotel
  • Check in time: 16:00
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From$90
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Blossom Hotel Houston - Houston 7118 Bertner Ave., Houston, TX 77030
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~2.68 miles west of 77221
  • Four-star Convention Center property
  • Check in: 3:00PM
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From$169
Average 3.0 /5 Review Score Call BookMore Details
Days Inn & Suites by Wyndham Downtown / University of Houston : 6190 Gulf Freeway 6190 Gulf Freeway, Houston, TX 77023
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~2.72 miles east of 77221
  • Three Star Downtown property
  • Complimentary breakfast is offered
More Photos Photo of Days Inn & Suites by Wyndham Downtown / University of Houston
From$55
Average 3.0 /5 Reviews Call BookMore Details
Lexington Hotel Houston Medical Center 1025 Swanson St., Houston, TX 77030
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~2.78 miles west of 77221
  • Inexpensive Downtown hotel
  • Check-in time: 3:00 PM
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From$60
Average 3.5 /5 Reviews Call BookMore Details
Hyatt Place in Houston 7329a Fannin St., Houston, TX 77030
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~2.78 miles west of 77221
  • Three Star hotel
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From$80
Average 3.0 /5 Recent Reviews Call BookMore Details
Hyatt Place Hyatt House Houston Medical Center 7329 Fannin St., Houston, TX 77030
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~2.78 miles west of 77221
  • Affordable Suburban hotel
  • Hotel has 298 rooms
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From$99
Average 3.0 /5 Latest Reviews Call BookMore Details
Houston Marriott Medical Center/Museum District 6580 Fannin St., Houston, TX 77030
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~2.80 miles west of 77221
  • 4 star Downtown property
  • Hotel has 22 suites
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From$75
Very Good 4.5 /5 Read Reviews Call BookMore Details
The Westin Hou Medical Center 1709 Dryden Rd., Houston, TX 77030
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~2.81 miles west of 77221
  • Mid-scale hotel
  • Fitness + Health Center
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From$90
Very Good 4.0 /5 Reviews Call BookMore Details
Sonder at Mid Main 3550 Main St., Houston, TX 77002
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~2.86 miles northwest of 77221
  • Affordable Downtown hotel
  • Check in time: 4:00 pm
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From$75
Average 3.0 /5 Reviews Call BookMore Details
Hampton Inn & Suites Houston Medical Center Nrg Park 1715 Old Spanish Trail, Houston, TX 77054
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~2.91 miles west of 77221
  • Mid-scale Convention Center hotel
  • Check-in: 3:00PM
More Photos Image of Hampton Inn & Suites Houston Medical Center Nrg Park
From$69
Very Good 4.0 /5 Read Reviews Call BookMore Details
Houston Medical Center Hotel in Houston 6700 Main St., Houston, TX 77030
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~2.94 miles west of 77221
  • 3 star Downtown property
  • 25 suites in property
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From$115
Average 3.5 /5 Reviews Call BookMore Details
InterContinental Houston by IHG in Houston 6750 Main St., Houston, TX 77030
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~2.98 miles west of 77221
  • 4-star Downtown property
  • Check-in time: 15:00
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From$75
Average 3.0 /5 Hotel Reviews Call BookMore Details
Doubletree by Hilton Houston Medical Center Hotel & Suites 6800 Main St., Houston, TX 77030
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~3.01 miles west of 77221
  • 4-star Downtown hotel
  • Hotel has 12 floors
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From$125
Average 3.0 /5 Latest Reviews Call BookMore Details
Extended Stay America - Houston - Med Ctr-NRG Park-Fannin 7979 Fannin, Houston, TX 77054
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~3.01 miles west of 77221
  • Economy Convention Center hotel
  • 12 suites in hotel
More Photos Photo of Extended Stay America - Houston - Med Ctr-NRG Park-Fannin
From$49
Poor 2.5 /5 Hotel Reviews Call BookMore Details
Holiday Inn Express Houston Downtown : 1810 Bell St. 1810 Bell St., Houston, TX 77003
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~3.10 miles north of 77221
  • Mid-scale Downtown property
  • Check in time: 3:00pm
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From$80
Average 3.0 /5 Hotel Reviews Call BookMore Details
Wanderstay Boutique Hotel 520 Sampson St., Houston, TX 77003
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~3.15 miles north of 77221
  • Four star property
  • Check-in: 2:00PM CST
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From$125
Average 3.0 /5 Recent Reviews Call BookMore Details
SpringHill Suites Houston Medical Center/NRG Park in Houston 1400 Old Spanish Trl, Houston, TX 77054
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~3.32 miles west of 77221
  • Midscale Downtown property
  • Hotel has 190 suites
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From$80
Average 3.0 /5 Latest Reviews Call BookMore Details
Whyhotel Houston Downtown 1515 Austin St., Houston, TX 77002
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~3.33 miles north of 77221
  • Affordable hotel
  • Check in time: 15:00
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From$90
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Athens Hotel Suites 1308 Clay St., Houston, TX 77002
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~3.39 miles north of 77221
  • Midscale Downtown property
  • Check in time: 3PM
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From$89
Average 3.0 /5 Review Score Call BookMore Details
La Colombe D Or Hotel : 3410 Montrose Blvd. 3410 Montrose Blvd., Houston, TX 77006
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~3.40 miles northwest of 77221
  • 3-star property
  • Check in time: 16:00
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From$90
Average 3.0 /5 Reviews Call BookMore Details
Hilton Americas Houston - Houston 1600 Lamar St., Houston, TX 77010
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~3.40 miles north of 77221
  • High-end Downtown property
  • 66 suites in property
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From$101
Very Good 4.5 /5 Hotel Reviews Call BookMore Details
Hotel Saint Augustine 4110 Loretto Dr., Houston, TX 77006
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~3.41 miles northwest of 77221
  • 4 star Downtown hotel
  • 71 sleeping rooms in hotel
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From$401
Average 3.0 /5 Latest Reviews Call BookMore Details
Embassy Suites Houston Downtown - Houston 1515 Dallas, Houston, TX 77010
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~3.42 miles north of 77221
  • 3 star Downtown property
  • Hotel has 5 meeting rooms
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From$135
Very Good 4.0 /5 Reviews Call BookMore Details
Sonder Midtown 306 Mcgowen St., Houston, TX 77006
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~3.44 miles northwest of 77221
  • 3-star Downtown property
  • Gym / Fitness Center Available
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From$75
Average 3.0 /5 Review Score Call BookMore Details
Holiday Inn Houston Downtown by IHG 1616 Main St., Houston, TX 77002
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~3.46 miles north of 77221
  • 3-star Downtown property
  • Access to gym on-site
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From$79
Poor 2.0 /5 Recent Reviews Call BookMore Details
Marriott Marquis Houston in Houston 1777 Walker St., Houston, TX 77010
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~3.46 miles north of 77221
  • Four-star property
  • 76 conference rooms in property
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From$375
Very Good 4.0 /5 Reviews Call BookMore Details
Courtyard by Marriott Houston Medical Center/NRG Park in Houston Houston Medical Center 7702 Main St., Houston, TX 77030
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~3.47 miles west of 77221
  • Affordable Suburban hotel
  • Fitness + Health Center
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From$69
Very Good 4.0 /5 Read Reviews Call BookMore Details
Sonder Lofts at Ballpark 610 St. Emanuel St. Houston Tx 77003, Houston, TX 77003
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~3.47 miles north of 77221
  • Mid-scale Downtown hotel
  • Hotel has 22 rooms
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From$100
Average 3.0 /5 Recent Reviews Call BookMore Details
The Reside 7755 South Main St., Houston, TX 77054
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~3.50 miles west of 77221
  • Midscale Downtown hotel
  • Hotel has 36 suites
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From$55
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Holiday Inn Houston S - Nrg Area - Medical Center by IHG in Houston 8111 Kirby Dr., Houston, TX 77054
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~3.50 miles west of 77221
  • Affordable Suburban property
  • 11 floors in hotel
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From$126
Average 3.5 /5 Review Score Call BookMore Details
Four Seasons Hotel Houston in Houston 1300 Lamar St., Houston, TX 77010
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~3.51 miles north of 77221
  • Luxury 5-star Downtown hotel
  • Access to gym on-site
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From$275
Very Good 4.0 /5 Reviews Call BookMore Details
Extended Stay America Suites Houston Med Ctr NRG Park Kirby - Houston 1303 La Concha Ln, Houston, TX 77054
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~3.52 miles west of 77221
  • 2-star Convention Center hotel
  • 45 suites in hotel
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From$41
Average 3.0 /5 Read Reviews Call BookMore Details
Courtyard Houston Medical Center / Nrg Park - Houston 7702 Main St., Houston, TX 77030
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~3.55 miles west of 77221
  • Mid-scale Downtown property
  • Hotel has 8 floors
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From$80
Average 3.0 /5 Guest Reviews Call BookMore Details
Bayou City Event Center 9401 Knight Rd., Houston, TX 77045
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~3.55 miles southwest of 77221
  • Two-star property
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From$60
Average 3.0 /5 Recent Reviews Call BookMore Details
Residence Inn Houston Medical Center / Nrg Park 7807 Kirby Dr., Houston, TX 77030
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~3.56 miles west of 77221
  • 3 star Downtown hotel
  • 182 rooms in hotel
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From$109
Very Good 4.0 /5 Latest Reviews Call BookMore Details

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Graph: Upcoming 20 Days of Houston Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Houston, TX discounts available. The chart reflects the cheapest Houston hotel for each day and each star rating category.

FAQs about hotels near 77221

What are the most favored hotels near 77221?

Home2 Suites, Hotel Zaza Houston Museum District and Houston Marriott Medical Center are the best rated hotels based on customer reviews in the last 365 days.

What are the most luxurious hotels near 77221?

Four Seasons Hotel Houston, Cliù Luxury Boutique Condo Hotel and Hilton University of Houston are the top 3 luxury hotels near 77221.

What hotels are closest to the area of 77221?

Cliù Luxury Boutique Condo Hotel, Extended Stay America Suites Houston Med Ctr Greenway Plaza, and Summit Inn - Houston Medical Center are the properties closest to 77221.

How much does a cheap hotel near 77221 cost per night?

In the last year, a 2 star hotel near 77221 can be as cheap as $63.37 per night. (based on HotelPlanner prices)

How much does a 3 star hotel near 77221 cost per night?

In the last year, the average 3 star hotel near 77221 has been $85.49 per night. (based on HotelPlanner prices)

How much does a 4-5 star hotel near 77221 cost?

In the last year, the average 4 star hotel near 77221 has been $111.54 per night. (based on HotelPlanner prices)

What are the best independent hotels near 77221?

Hotel Zaza Houston Museum District, Scott Inn Suites Downtown Houston and Blossom Houston Medical Center are the best rated independent hotels (not part of a big brand).

What are the most popular Marriott hotels near 77221?

Houston Marriott Medical Center, The Westin Hou Medical Center and Marriott Marquis Houston are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the best IHG hotels near 77221?

Holiday Inn Houston S - Nrg Area - Medical Center by IHG, Holiday Inn Houston Downtown by IHG and InterContinental Houston by IHG are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

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