Star Rating
Hotel Name
Price Range (USD)to
Amenities

77221 Hotels/Motels & Accommodations

Extended Stay America Houston Greenway Plaza 2330 SW Frwy, Houston, TX 77098 ~1.17 miles west of 77221
  • Low priced Downtown hotel
  • Gym is available on property
  • Most guests liked the proximity to shopping
  • Bathroom is relatively clean
Hilton University of Houston : 4800 Calhoun Rd. 4800 Calhoun Rd., Houston, TX 77004 ~1.39 miles northeast of 77221
  • 4 star Downtown property
  • Hotel has 8 floors
  • About half of guests said rooms were big enough
  • Terrible value
Hilton University of Houston - Houston
+1-800-881-1523
4450 University Dr., Houston, TX 77204 ~1.40 miles northeast of 77221
  • High end property
  • Every guests reviewed found the staff to be very friendly
  • Great service
Mainstay Suites in Houston 3134 Old Spanish Trail, Houston, TX 77054 ~1.49 miles west of 77221
  • Cheap Convention Center property
  • 92 suites in property
  • The majority of guests found the kitchenette to be good
  • Free airport shuttle
Extended Stay Deluxe Houston Medical Center
+1-866-221-8581
1301 Braeswood Blvd., Houston, TX 77030 ~2.52 miles west of 77221
  • Mid-scale Convention Center hotel
  • 130 rooms in property
  • Entrance area is not particularly attractive
  • Close to the medical center
Hotel Zaza Houston - Houston 5701 Main St., Houston, TX 77005 ~2.57 miles northwest of 77221
  • Four-star Downtown property
  • Check-in: 4:00 PM
  • Great spa experience
  • Rooms could be larger
From$189
Very Good 4.5 /5Read Reviews CallBookMore Details
Lexington Hotel Houston Medical Center - Houston
+1-888-690-5281
1025 Swanson St., Houston, TX 77030 ~2.75 miles west of 77221
  • Mid-scale Downtown hotel
  • Check in: 3:00 PM
Houston Marriott Medical Center in Houston 6580 Fannin St., Houston, TX 77030 ~2.80 miles west of 77221
  • High end Downtown property
  • 14 meeting rooms in property
From$89
Very Good 4.0 /5Review Score CallBookMore Details
Hampton Inn & Suites Medical Center - Houston 1715 Old Spanish Trail, Houston, TX 77054 ~2.92 miles west of 77221
  • 3 star Convention Center hotel
  • 37 suites in property
From$75
Very Good 4.0 /5Read Reviews CallBookMore Details
Best Western Plaza Hotel & Suites at Medical Cente : 6700 South Main St.
+1-800-881-1523
6700 South Main St., Houston, TX 77030 ~2.94 miles west of 77221
  • 3 star Downtown property
  • Hotel has 6 floors
Hilton Houston Plaza / Medical Center in Houston 6633 Travis St., Houston, TX 77030 ~2.94 miles west of 77221
  • High end Downtown hotel
  • Check-in: 03:00 PM
  • Average hotel building
  • Close to all museums
Best Western Plaza Hotel & Suites at Medical Center 6700 Main St., Houston, TX 77030 ~2.94 miles west of 77221
  • 3-star hotel
  • 125 sleeping rooms in hotel
Robin's Nest Bed & Breakfast Inn in Houston
+1-866-429-5787
4104 Greeley St., Houston, TX 77006 ~2.99 miles northwest of 77221
  • Affordable Downtown hotel
  • Comp. Breakfast
From$195
Very Good 4.5 /5Read Reviews CallBookMore Details
Wyndham Houston Medical Center Hotel & Suite 6800 Main St., Houston, TX 77030 ~2.99 miles west of 77221
  • 3-star Downtown property
  • Gym / Fitness Center Available
  • Every guests reviewed thought it was a great value
  • No vending machines
Extended Houston Med. Center Ngr Pk. Fannin S (Med - Houston 7979 Fannin, Houston, TX 77054 ~3.02 miles west of 77221
  • Low Cost Convention Center hotel
  • 3 floors in property
  • Most guests said rooms were dirty
  • Horrible costumer service
Holiday Inn Express & Suites Downtown - Houston 1810 Bell St., Houston, TX 77003 ~3.14 miles north of 77221
  • Mid-scale Downtown hotel
  • Fitness center on property
Springhill Suites by Marriott Houston Nrg Park : 1400 Old Spanish Trail 1400 Old Spanish Trail, Houston, TX 77054 ~3.33 miles west of 77221
  • Three Star Downtown hotel
  • 190 suites in property
  • Most guests said rooms were clean enough
  • Wonderful sightseeing
Athens Hotel in Houston 1308 Clay St., Houston, TX 77002 ~3.41 miles north of 77221
  • 2-star Downtown hotel
  • Hotel has 2 floors
  • For 71%, parking prices were too high
  • Furniture needs more attention
Embassy Suites Houston Downtown 1515 Dallas, Houston, TX 77010 ~3.43 miles north of 77221
  • Midscale Downtown hotel
  • Check-in: 3:00PM
From$139
Very Good 4.5 /5Recent Reviews CallBookMore Details
Holiday Inn Houston Downtown - Houston 1616 Main St., Houston, TX 77002 ~3.46 miles north of 77221
  • 3-star Downtown property
  • Check in: 3:00 PM
Holiday Inn Houston N R G Park Area in Houston 8111 Kirby Dr., Houston, TX 77054 ~3.51 miles west of 77221
  • Mid-scale Suburban hotel
  • 6 suites in hotel
  • Great parking, according to 71%
  • Great location
Extended Stay Deluxe Houston Medical Center La Con : 1303 La Concha Ln 1303 La Concha Ln, Houston, TX 77054 ~3.52 miles west of 77221
  • Low priced Convention Center hotel
  • 45 suites in hotel
  • Friendly staff
  • Faucet was not working
From$41
Very Good 4.5 /5Read Reviews CallBookMore Details
Four Seasons Hotel Houston : 1300 Lamar St. 1300 Lamar St., Houston, TX 77010 ~3.52 miles north of 77221
  • Luxury Five Star Downtown hotel
  • Fitness + Health Center
  • Terrific location
  • The majority of guests had problems with the shower
From$125
Very Good 4.5 /5Latest Reviews CallBookMore Details
Moody Manor at the Houston Medical Center 7706 South Main St., Houston, TX 77030 ~3.53 miles west of 77221
  • Cheap Downtown property
  • 54 rooms in property
  • Bathroom is relatively clean
  • Tasty breakfast
Residence Inn by Marriott Medical Center / Reliant 7710 Main St., Houston, TX 77030 ~3.54 miles west of 77221
  • 3-star Highway hotel
  • Complimentary breakfast is offered
  • Tasty breakfast
  • Friendly service
From$85
Average 3.5 /5Reviews CallBookMore Details
Courtyard by Marriott Houston Medical Center : Houston Medical Center 7702 Main St. Houston Medical Center 7702 Main St., Houston, TX 77030 ~3.56 miles west of 77221
  • Three Star Suburban property
  • 8 suites in hotel
  • Breakfast is average
  • Most guests thought rooms were spacious
From$159
Very Good 4.0 /5Reviews CallBookMore Details
Moody Manor - Houston 7706 Main St., Houston, TX 77030 ~3.58 miles west of 77221
  • 3-star Downtown property
  • Hotel has 2 floors
Hampton Inn Houston Downtown : 710 Crawford St. 710 Crawford St., Houston, TX 77002 ~3.58 miles north of 77221
  • 3 star Convention Center property
  • Hotel has 300 rooms
From$95
Very Good 4.5 /5Reviews CallBookMore Details
The Whitehall Houston : 1700 Smith St. 1700 Smith St., Houston, TX 77002 ~3.62 miles north of 77221
  • 4 star Downtown hotel
  • Check in: 12 Noon
  • Pool should be renewed
  • The price was ok for 58%
From$88
Very Good 4.5 /5Review Score CallBookMore Details
Rodeway Inn Suites
+1-888-305-3366
6712 Morningside Dr., Houston, TX 77030 ~3.63 miles west of 77221
  • Two star Downtown hotel
  • 33 rooms in property
  • Great shopping
  • Older property
Residence Inn Houston Downtown 904 Dallas St., Houston, TX 77002 ~3.64 miles north of 77221
  • 3-star Downtown hotel
  • 171 suites in hotel
Courtyard by Marriott Houston Downtown : 916 Dallas St. 916 Dallas St., Houston, TX 77002 ~3.64 miles north of 77221
  • 3 star Downtown property
  • Gym is available on property
Springhill Suites Houston Downtown / Convention Center - Houston 914 Dallas St., Houston, TX 77002 ~3.65 miles north of 77221
  • Mid-scale property
The Westin Houston Downtown - Houston
+1-866-429-5787
1520 Texas Ave., Houston, TX 77002 ~3.71 miles north of 77221
  • High end Downtown hotel
  • Check in time: 3:00 PM
  • Vibe was good
  • WiFi system needs upgrading
From$109
Very Good 4.5 /5Recent Reviews CallBookMore Details
Hotel Ylem : 8080 South Main St. 8080 South Main St., Houston, TX 77025 ~3.72 miles west of 77221
  • Mid-scale Downtown hotel
  • 3 floors in property
  • Room was quiet
  • Fresh fruit
From$69
Very Good 4.0 /5Reviews CallBookMore Details
Aloft Houston Downtown - Houston 820 Fannin St., Houston, TX 77002 ~3.76 miles north of 77221
  • 3 star Downtown property
  • Check-in: 3:00 PM
Hyatt Regency Houston - Houston 1200 Louisiana St., Houston, TX 77002 ~3.76 miles north of 77221
  • 4 star Downtown property
  • Hotel has 947 rooms
From$179
Very Good 4.0 /5Read Reviews CallBookMore Details
Club Quarters Hotel Houston 720 Fannin St., Houston, TX 77002 ~3.80 miles north of 77221
  • Four star hotel
  • Hotel has 100 rooms
From$125
Very Good 4.0 /5Review Score CallBookMore Details
JW Marriott Houston Downtown
+1-888-283-3404
806 Main, Houston, TX 77002 ~3.82 miles north of 77221
  • Luxury 5 star Downtown hotel
  • 56 suites in hotel
From$139
Very Good 4.5 /5Read Reviews CallBookMore Details
Magnolia Hotel in Houston 1100 Texas Ave., Houston, TX 77002 ~3.84 miles north of 77221
  • 4 star Downtown property
  • Comp. Breakfast
  • Awesome vibe
  • Hotel - Staff were very welcoming
Comfort Suites in Houston 1055 Mcnee Rd., Houston, TX 77054 ~3.85 miles west of 77221
  • 3-star Convention Center property
  • Hotel has 52 rooms
Crowne Plaza Houston Near Reliant Medical
+1-888-690-5281
8686 Kirby Dr., Houston, TX 77054 ~3.86 miles west of 77221
  • 3 star Convention Center hotel
  • 33 meeting rooms in hotel
Doubletree by Hilton Houston Downtown : 400 Dallas St. 400 Dallas St., Houston, TX 77002 ~3.86 miles north of 77221
  • Affordable Downtown hotel
  • Check-in time: 3:00pm
  • Perfect breakfast
  • Gorgeous suite
From$80
Very Good 4.0 /5Read Reviews CallBookMore Details
The Sam Houston Hotel Curio a Collection by Hilton - Houston 1117 Prairie St., Houston, TX 77002 ~3.91 miles north of 77221
  • Four-star Downtown property
  • Fitness center on property
Best Western Plus Downtown Inn & Suites : 915 West Dallas St. 915 West Dallas St., Houston, TX 77019 ~3.97 miles north of 77221
  • Midscale Downtown property
  • 50 suites in property
  • Air conditioning was criticized by 86%
  • Most guests found the staff to be very friendly
From$115
Very Good 4.5 /5Guest Reviews CallBookMore Details
The Quality Inn & Suites Reliant Park 2364 South Loop West, Houston, TX 77054 ~3.99 miles west of 77221
  • Three Star Convention Center hotel
  • Fitness center on property
  • Fair breakfast prices
  • Most guests said rooms were dirty
Staybridge Suites Houston Medical Center - Houston 9000 South Main St., Houston, TX 77025 ~4.02 miles west of 77221
  • Midscale Downtown property
  • Airport shuttle available
From$109
Average 3.0 /5Reviews CallBookMore Details
The Lancaster Hotel 701 Texas Ave., Houston, TX 77002 ~4.03 miles north of 77221
  • Four-star Downtown hotel
  • Gym is available on property
From$125
Very Good 4.5 /5Latest Reviews CallBookMore Details
Hotel Icon Houston - Houston 220 Main St., Houston, TX 77002 ~4.08 miles north of 77221
  • Four star Downtown hotel
  • 15 suites in hotel
Holiday Inn Express & Suites Houston S Medical Center Area 9300 South Main St., Houston, TX 77025 ~4.31 miles west of 77221
  • 2 star Downtown hotel
  • Hotel has 30 suites
From$89
Excellent 5.0 /5Read Reviews CallBookMore Details

Next: Show All Available 77221 Hotels with Pricing
Back to Top