Star rating
Hotel name
Price range (GBP) to
Amenities
+ more

65280 Hotels & Accommodations

America's Value Inn Mexico
+1-888-389-4121
4224 South Clark St., Mexico, MO 65265 ~11.59 miles west of 65280
  • Low Cost Airport hotel
  • Complimentary breakfast is offered
From$35
Very good 4.0 /5 Review Score Call BookMore Details
Tired of clicking around? Talk to an expert Hotel Planner: (855) 276-7561 or say...
alexa hotel planner skill"Alexa, ask Hotel Planner to make a new reservation in 65280" Get Alexa Skill →
Days Inn by Wyndham Mexico
+1-888-675-2083
2902 South Clark, Mexico, MO 65265 ~11.66 miles west of 65280
  • Low Cost Suburban property
  • Free complimentary breakfast
From$60
Average 3.0 /5 Latest Reviews Call BookMore Details
Best Western Teal Lake Inn
+1-800-716-8490
3602 South Clark St., Mexico, MO 65265 ~12.16 miles west of 65280
  • Affordable Suburban property
  • Free comp. breakfast
From$64
Very good 4.0 /5 Guest Reviews Call BookMore Details
Country Hearth Inn & Suites Mexico : 900 Vance Rd.
+1-800-805-5223
900 Vance Rd., Mexico, MO 65265 ~12.90 miles west of 65280
  • Midscale Highway hotel
  • Check in: 3:00 PM
From$44
Average 3.5 /5 Guest Reviews Call BookMore Details
Baymont by Wyndham in Kingdom City
+1-888-965-1860
5750 Jade Rd., Kingdom City, MO 65262 ~22.09 miles southwest of 65280
  • Inexpensive hotel
  • 3 floors in hotel
From$73
Average 3.0 /5 Review Score Call BookMore Details
Super 8 by Wyndham Kingdom City
+1-888-788-5576
3370 Gold Ave., Kingdom City, MO 65262 ~22.55 miles southwest of 65280
  • Cheap Suburban hotel
  • Hotel has a green policy See policy
From$60
Average 3.0 /5 Review Score Call BookMore Details
Quality Inn : 3207 County Rd. 211
+1-888-897-9207
3207 County Rd. 211, Kingdom City, MO 65262 ~22.57 miles southwest of 65280
  • Mid-scale Highway property
  • 2 suites in property
From$80
Average 3.0 /5 Latest Reviews Call BookMore Details
Holiday Inn Express & Suites Kingdom City by IHG
+1-888-311-4278
3257 County Rd. 211, Kingdom City, MO 65262 ~22.64 miles southwest of 65280
  • Economical property
  • 85 rooms in hotel
From$60
Very good 4.0 /5 Latest Reviews Call BookMore Details
Days Inn by Wyndham Kingdom City - Kingdom City
+1-888-469-4795
3391 County Rd. 211, Kingdom City, MO 65262 ~22.69 miles southwest of 65280
  • Two-star Highway hotel
  • 2 floors in property
From$60
Average 3.0 /5 Read Reviews Call BookMore Details
Americas Best Value Inn New Florence
+1-888-734-9421
202 Clark Dr., New Florence, MO 63363 ~23.05 miles southeast of 65280
  • Cheap property
  • Free complimentary breakfast
Knights Inn New Florence
+1-888-841-5292
403 Booneslick Rd., New Florence, MO 63363 ~23.11 miles southeast of 65280
  • 2-star hotel
From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
America's Best Inn New Florence - New Florence
+1-888-455-5160
1 Proactive Dr., New Florence, MO 63363 ~23.37 miles southeast of 65280
  • 2-star hotel
From$60
Very good 4.0 /5 Guest Reviews Call BookMore Details
Baymont by Wyndham Fulton - Fulton
+1-888-965-8297
2205 Cardinal Dr., Fulton, MO 65251 ~26.78 miles southwest of 65280
  • Affordable Rural hotel
  • Free complimentary breakfast
From$60
Very good 4.0 /5 Guest Reviews Call BookMore Details
Motel 70
+1-888-906-6358
930 Tree Farm Rd., High Hill, MO 65330 ~27.28 miles southeast of 65280
  • Inexpensive hotel
  • 13 sleeping rooms in hotel
From$30
Very good 4.0 /5 Recent Reviews Call BookMore Details
Super 8 by Wyndham Bowling Green in Bowling Green
+1-888-749-6785
1216 East Champ Clark Dr., Bowling Green, MO 63334 ~28.26 miles east of 65280
  • Economy Rural hotel
  • 64 rooms in property
From$56
Very good 4.0 /5 Read Reviews Call BookMore Details
Need some questions answered? Talk to an expert Hotel Planner: (855) 276-7561 or say...
alexa hotel planner skill"Alexa, ask Hotel Planner to make a new reservation in 65280" Get Alexa Skill →
Amerihost Inn & Suites Fulton
+1-888-878-9982
556 Amerihost Dr., Fulton, MO 65251 ~28.66 miles southwest of 65280
  • Cheap Highway hotel
  • Check-in: 3:00 PM
From$60
Very good 4.0 /5 Read Reviews Call BookMore Details
FairBridge Inn Express, Monroe City
+1-888-389-4485
3 Gateway Sq. Dr., Monroe City, MO 63456 ~32.31 miles north of 65280
  • Cheap Suburban hotel
  • Check-in: 3:00 pm
From$60
Average 3.0 /5 Recent Reviews Call BookMore Details
Super 8 by Wyndham Columbia East - Columbia
+1-888-389-4121
5700 Freedom Dr., Columbia, MO 65202 ~34.76 miles west of 65280
  • Low-priced Highway property
  • Check in time: 2 P.M.
From$60
Average 3.0 /5 Recent Reviews Call BookMore Details
Holiday Inn Columbia East An Ihg Hotel
+1-888-675-2083
915 Port Way, Columbia, MO 65201 ~34.92 miles west of 65280
  • Two-star Suburban hotel
  • Access to gym on-site
From$60
Average 3.0 /5 Latest Reviews Call BookMore Details
Hilton Garden Inn Columbia - Columbia
+1-800-716-8490
3300 Vandiver Dr., Columbia, MO 65202 ~36.20 miles west of 65280
  • Three Star Suburban hotel
  • 151 rooms in hotel
From$93
Very good 4.0 /5 Latest Reviews Call BookMore Details
Springhill Suites by Marriott Columbia : 3415 Clark Lane
+1-800-805-5223
3415 Clark Lane, Columbia, MO 65202 ~36.29 miles west of 65280
  • Affordable Highway property
  • 4 floors in property
From$129
Average 3.0 /5 Guest Reviews Call BookMore Details
Residence Inn by Marriott Columbia
+1-888-965-1860
1100 Woodland Springs Court, Columbia, MO 65202 ~36.30 miles west of 65280
  • Three Star Suburban hotel
  • 80 suites in hotel
From$80
Very good 4.0 /5 Reviews Call BookMore Details
Candlewood Suites Columbia East by IHG
+1-888-788-5576
1400 Creekwood Pkwy., Columbia, MO 65202 ~36.37 miles west of 65280
  • Low priced Suburban property
  • Check in time: 3:00pm
From$55
Very good 4.0 /5 Guest Reviews Call BookMore Details
Fairfield Inn & Suites Columbia : 1115 Woodland Springs Court
+1-888-897-9207
1115 Woodland Springs Court, Columbia, MO 65202 ~36.38 miles west of 65280
  • Midscale Highway property
  • Hotel has 3 floors
From$80
Average 3.0 /5 Hotel Reviews Call BookMore Details
Hampton Inn Columbia in Columbia
+1-888-311-4278
3410 Clark Lane, Columbia, MO 65202 ~36.44 miles west of 65280
  • Mid-scale Highway hotel
  • Fitness / Gym is on-site
From$99
Very good 4.5 /5 Guest Reviews Call BookMore Details
Motel 6 Columbia East Mo in Columbia
+1-888-469-4795
3402 Interstate 70 Dr. Southeast, Columbia, MO 65201 ~36.44 miles west of 65280
  • 2 star hotel
  • Hotel has 61 rooms
From$60
Very good 4.0 /5 Recent Reviews Call BookMore Details
Super 8 by Wyndham Columbia Clark Lane
+1-888-734-9421
3216 Clark Lane, Columbia, MO 65202 ~36.53 miles west of 65280
  • Cheap Highway property
  • 6 suites in hotel
Staybridge Suites Columbia by IHG
+1-888-841-5292
805 Keene St., Columbia, MO 65201 ~36.60 miles west of 65280
  • 3 star Suburban property
  • Hotel has 81 rooms
From$66
Very good 4.5 /5 Guest Reviews Call BookMore Details
Quality Inn & Suites Columbia I-70 - Columbia
+1-888-455-5160
801 Keene St., Columbia, MO 65201 ~36.60 miles west of 65280
  • Inexpensive Downtown property
  • Gym is available on property
From$60
Average 3.0 /5 Read Reviews Call BookMore Details
Howard Johnson Inn Columbia in Columbia
+1-888-965-8297
3100 I 70 Dr. Southeast, Columbia, MO 65201 ~36.62 miles west of 65280
  • 2 star Highway hotel
  • Fitness / Gym is on-site
From$60
Average 3.0 /5 Review Score Call BookMore Details
Drury Plaza Hotel Columbia East : 3100 Interstate 70 Dr. Se
+1-888-906-6358
3100 Interstate 70 Dr. Se, Columbia, MO 65201 ~36.63 miles west of 65280
  • Midscale Suburban property
  • Check in time: 3:00 pm
From$136
Average 3.0 /5 Read Reviews Call BookMore Details
Country Inn & Suites by Radisson, Columbia, MO - Columbia
+1-888-749-6785
817 North Keene St., Columbia, MO 65201 ~36.67 miles west of 65280
  • Midscale Highway property
  • Hotel has 85 rooms
From$80
Very good 4.5 /5 Latest Reviews Call BookMore Details
Quality Inn & Suites Columbia I-70 : 801 North Keene St.
+1-888-878-9982
801 North Keene St., Columbia, MO 65201 ~36.71 miles west of 65280
  • 3-star Downtown hotel
  • Hotel has an eco-friendly policy See policy
From$52
Average 3.5 /5 Hotel Reviews Call BookMore Details
Best Western Plus Columbia Inn
+1-888-389-4485
2904 Clark Ln, Columbia, MO 65202 ~36.74 miles west of 65280
  • Low-priced Suburban hotel
  • Hotel has an eco-friendly policy See more
From$80
Very good 4.0 /5 Guest Reviews Call BookMore Details
Wingate by Wyndham - Columbia
+1-888-389-4121
3101 Wingate Court, Columbia, MO 65201 ~36.78 miles west of 65280
  • Three Star Highway hotel
  • Hotel has 3 floors
From$89
Very good 4.0 /5 Recent Reviews Call BookMore Details
Ramada by Wyndham Columbia in Columbia
+1-888-675-2083
901 Conley Rd., Columbia, MO 65201 ~36.83 miles west of 65280
  • Economical Highway property
  • Check-in: 3:00pm
From$54
Average 3.5 /5 Review Score Call BookMore Details
Baymont by Wyndham Hannibal : 4141 Market St.
+1-800-716-8490
4141 Market St., Hannibal, MO 63401 ~37.02 miles northeast of 65280
  • Low priced Convention Center property
  • Check in: 2:00 PM
From$35
Average 3.0 /5 Guest Reviews Call BookMore Details
Days Inn by Wyndham Hannibal - Hannibal
+1-800-805-5223
4070 Market St., Hannibal, MO 63401 ~37.06 miles northeast of 65280
  • Low Cost property
  • Hotel has 2 floors
From$60
Average 3.0 /5 Hotel Reviews Call BookMore Details
Comfort Inn & Suites - Hannibal - Hannibal
+1-888-965-1860
4000 Market St., Hannibal, MO 63401 ~37.10 miles northeast of 65280
  • Inexpensive Highway property
  • Hotel has an eco-friendly policy Read more
From$75
Very good 4.0 /5 Latest Reviews Call BookMore Details
Holiday Inn Express Hotel & Suites Columbia Univ Area-Hwy 63 by I
+1-888-788-5576
1402 Cinnamon Hill Lane, Columbia, MO 65201 ~37.59 miles west of 65280
  • Midscale Highway hotel
  • Check in time: 4:00pm
From$80
Very good 4.0 /5 Reviews Call BookMore Details
Budget Host Inn in Columbia
+1-888-897-9207
900 Vandiver Dr., Columbia, MO 65202 ~38.13 miles west of 65280
  • 2 star Highway hotel
  • Free breakfast available
From$40
Average 3.0 /5 Review Score Call BookMore Details
Motel 6 Hannibal, MO in Hannibal
+1-888-311-4278
123 Huckleberry Heights Dr., Hannibal, MO 63401 ~38.16 miles northeast of 65280
  • Economy property
  • 48 rooms in hotel
From$60
Average 3.5 /5 Read Reviews Call BookMore Details
Super 8 by Wyndham Hannibal in Hannibal
+1-888-469-4795
120 Huckleberry Heights Dr., Hannibal, MO 63401 ~38.21 miles northeast of 65280
  • Inexpensive Highway hotel
  • Free comp. breakfast
From$60
Average 3.0 /5 Reviews Call BookMore Details
Sleep Inn & Suites - Hannibal
+1-888-734-9421
105 Lakeside Dr., Hannibal, MO 63401 ~38.23 miles north of 65280
  • 2-star hotel
  • Check-in time: 3:00
From$109
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Courtyard by Marriott Columbia Missouri in Columbia
+1-888-841-5292
3301 Lemone Industrial Blvd., Columbia, MO 65201 ~38.29 miles southwest of 65280
  • Mid-scale Highway hotel
  • 11 meeting rooms in property
From$99
Very good 4.5 /5 Hotel Reviews Call BookMore Details
Baymont by Wyndham Warrenton : 425 East Veterans Memorial Pkwy.
+1-888-455-5160
425 East Veterans Memorial Pkwy., Warrenton, MO 63383 ~38.55 miles southeast of 65280
  • Two-star Rural hotel
  • Free breakfast available
From$60
Average 3.0 /5 Recent Reviews Call BookMore Details
TownePlace Suites by Marriott Columbia - Columbia
+1-888-965-8297
4400 Nocona Pkwy., Columbia, MO 65201 ~38.55 miles southwest of 65280
  • Midscale property
  • 4 floors in property
From$85
Average 3.0 /5 Reviews Call BookMore Details
Quality Inn & Suites Hannibal : 120 Lindsey Dr.
+1-888-906-6358
120 Lindsey Dr., Hannibal, MO 63401 ~38.55 miles north of 65280
  • 3-star hotel
  • 17 suites in hotel
From$67
Very good 4.0 /5 Reviews Call BookMore Details
Red Roof Inn Columbia, MO
+1-888-749-6785
201 East Texas Ave., Columbia, MO 65202 ~38.57 miles west of 65280
  • Three Star Suburban property
  • Check-in time: 1:00 PM
From$44
Average 3.0 /5 Review Score Call BookMore Details
The Broadway Columbia a Doubletree by Hilton in Columbia
+1-888-878-9982
1111 East Broadway, Columbia, MO 65201 ~38.59 miles west of 65280
  • High-end Downtown property
  • Gym / Fitness Center Available
From$143
Very good 4.0 /5 Guest Reviews Call BookMore Details

Next: Show All Available 65280 Hotels with Pricing

Graph: Upcoming 20 Days of 65280 Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Mexico, MO discounts available. The chart reflects the cheapest Mexico hotel for each day and each star rating category.

FAQs about hotels near 65280

What are the top rated hotels near 65280?

Hampton Inn Columbia, Staybridge Suites Columbia by IHG and Country Inn & Suites by Radisson, Columbia, MO are the best rated hotels based on customer reviews in the last 365 days.

What are the most high-end hotels near 65280?

The Broadway Columbia a Doubletree by Hilton, Best Western Teal Lake Inn and Country Hearth Inn & Suites Mexico are the top 3 luxury hotels near 65280.

What hotels are closest to the area of 65280?

America's Value Inn Mexico, Days Inn by Wyndham Mexico, and Best Western Teal Lake Inn are the properties closest to 65280.

How much does a cheap hotel near 65280 cost per night?

In the last year, a 2 star hotel near 65280 can be as cheap as $63.47 per night. (based on HotelPlanner prices)

How much does a 3 star hotel near 65280 cost per night?

In the last year, the average 3 star hotel near 65280 has been $98.83 per night. (based on HotelPlanner prices)

How much does a higher-end hotel near 65280 cost?

In the last year, the average 4 star hotel near 65280 has been $160.00 per night. (based on HotelPlanner prices)

What are the best independent hotels near 65280?

America's Value Inn Mexico, America's Best Inn New Florence and Motel 70 are the best rated independent hotels (not part of a big brand).

What are the best Marriott hotels near 65280?

Courtyard by Marriott Columbia Missouri, Residence Inn by Marriott Columbia and Springhill Suites by Marriott Columbia are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the best Choice Hotels branded hotels near 65280?

Comfort Inn & Suites - Hannibal, Sleep Inn & Suites and Quality Inn & Suites Hannibal are the best rated Choice Hotels branded hotels (based on HotelPlanner reviews score).

What are the best Best Western hotels near 65280?

Best Western Teal Lake Inn and Best Western Plus Columbia Inn are the best rated Best Western branded hotels (based on user reviews score).

What are the most popular IHG hotels near 65280?

Staybridge Suites Columbia by IHG, Holiday Inn Express & Suites Kingdom City by IHG and Candlewood Suites Columbia East by IHG are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

Back to Top