Star Rating
Hotel Name
Price Range (USD) to
Amenities
+ More

65280 Hotels, Motels & Accommodations

America's Value Inn Mexico
+1-888-389-4121
4224 South Clark St., Mexico, MO 65265 ~11.59 miles west of 65280
  • Two star Airport property
  • Complimentary breakfast is offered
From$35
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Tired of clicking around? Talk to an expert Hotel Planner: (855) 276-7561 or say...
alexa hotel planner skill"Alexa, ask Hotel Planner to make a new reservation in 65280" Get Alexa Skill →
Days Inn by Wyndham Mexico in Mexico
+1-888-675-2083
2902 South Clark, Mexico, MO 65265 ~11.66 miles west of 65280
  • 2 star Suburban hotel
  • Check-in time: 11:00 AM
From$60
Average 3.0 /5 Recent Reviews Call BookMore Details
Best Western Teal Lake Inn - Mexico
+1-800-716-8490
3602 South Clark St., Mexico, MO 65265 ~12.16 miles west of 65280
  • Three Star Suburban property
  • 2 suites in property
From$64
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Country Hearth Inn & Suites Mexico - Mexico
+1-800-805-5223
900 Vance Rd., Mexico, MO 65265 ~12.90 miles west of 65280
  • Three Star Highway property
  • Check-in time: 3:00 PM
From$44
Average 3.5 /5 Guest Reviews Call BookMore Details
Baymont by Wyndham in Kingdom City
+1-888-965-1860
5750 Jade Rd., Kingdom City, MO 65262 ~22.09 miles southwest of 65280
  • 2-star hotel
  • Check in time: 3:00 PM
From$73
Average 3.0 /5 Read Reviews Call BookMore Details
Super 8 by Wyndham Kingdom City : 3370 Gold Ave.
+1-888-788-5576
3370 Gold Ave., Kingdom City, MO 65262 ~22.55 miles southwest of 65280
  • Two-star Suburban hotel
  • Check-in time: 2:00pm
From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
Quality Inn : 3207 County Rd. 211
+1-888-897-9207
3207 County Rd. 211, Kingdom City, MO 65262 ~22.57 miles southwest of 65280
  • Midscale Highway hotel
  • Fitness center on property
From$80
Average 3.0 /5 Recent Reviews Call BookMore Details
Holiday Inn Express & Suites Kingdom City by IHG
+1-888-311-4278
3257 County Rd. 211, Kingdom City, MO 65262 ~22.64 miles southwest of 65280
  • 2 star property
  • 6 suites in property
From$60
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Days Inn by Wyndham Kingdom City - Kingdom City
+1-888-469-4795
3391 County Rd. 211, Kingdom City, MO 65262 ~22.69 miles southwest of 65280
  • Low-priced Highway hotel
  • Check-in: 15:00
From$60
Average 3.0 /5 Read Reviews Call BookMore Details
Americas Best Value Inn New Florence
+1-888-734-9421
202 Clark Dr., New Florence, MO 63363 ~23.05 miles southeast of 65280
  • Economical property
  • 2 floors in hotel
Knights Inn New Florence - New Florence
+1-888-841-5292
403 Booneslick Rd., New Florence, MO 63363 ~23.11 miles southeast of 65280
  • 2 star hotel
From$60
Average 3.0 /5 Review Score Call BookMore Details
America's Best Inn New Florence in New Florence
+1-888-455-5160
1 Proactive Dr., New Florence, MO 63363 ~23.37 miles southeast of 65280
  • 2-star property
From$60
Very Good 4.0 /5 Read Reviews Call BookMore Details
Baymont by Wyndham Fulton - Fulton
+1-888-965-8297
2205 Cardinal Dr., Fulton, MO 65251 ~26.78 miles southwest of 65280
  • Three Star Rural property
  • Check in: 3:00 PM
From$60
Very Good 4.0 /5 Review Score Call BookMore Details
Motel 70 in High Hill
+1-888-906-6358
930 Tree Farm Rd., High Hill, MO 65330 ~27.28 miles southeast of 65280
  • Two-star hotel
  • Check in: 1:00 PM
From$30
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Super 8 by Wyndham Bowling Green
+1-888-749-6785
1216 East Champ Clark Dr., Bowling Green, MO 63334 ~28.26 miles east of 65280
  • Two star Rural hotel
  • 64 rooms in property
From$56
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Need some questions answered? Talk to an expert Hotel Planner: (855) 276-7561 or say...
alexa hotel planner skill"Alexa, ask Hotel Planner to make a new reservation in 65280" Get Alexa Skill →
Capital O Amerihost Inn and Suites Fulton Hwy 54 MO : 556 Amerihost Dr.
+1-888-878-9982
556 Amerihost Dr., Fulton, MO 65251 ~28.66 miles southwest of 65280
  • 2 star Highway hotel
  • Check-in time: 3:00 PM
From$60
Very Good 4.0 /5 Read Reviews Call BookMore Details
FairBridge Inn Express, Monroe City in Monroe City
+1-888-389-4485
3 Gateway Sq. Dr., Monroe City, MO 63456 ~32.31 miles north of 65280
  • Economy Suburban property
  • 2 floors in hotel
From$60
Average 3.0 /5 Hotel Reviews Call BookMore Details
Super 8 by Wyndham Columbia East : 5700 Freedom Dr.
+1-888-389-4121
5700 Freedom Dr., Columbia, MO 65202 ~34.76 miles west of 65280
  • Two-star Highway hotel
From$60
Average 3.0 /5 Reviews Call BookMore Details
Holiday Inn Columbia East An Ihg Hotel : 915 Port Way
+1-888-675-2083
915 Port Way, Columbia, MO 65201 ~34.92 miles west of 65280
  • Low Cost Suburban property
  • 5 floors in hotel
From$60
Average 3.0 /5 Reviews Call BookMore Details
Hilton Garden Inn Columbia
+1-800-716-8490
3300 Vandiver Dr., Columbia, MO 65202 ~36.20 miles west of 65280
  • Three Star Suburban hotel
  • 151 sleeping rooms in hotel
From$93
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Springhill Suites by Marriott Columbia : 3415 Clark Lane
+1-800-805-5223
3415 Clark Lane, Columbia, MO 65202 ~36.29 miles west of 65280
  • 3 star Highway hotel
  • Hotel has an eco-friendly policy See policy
From$129
Average 3.0 /5 Latest Reviews Call BookMore Details
Residence Inn by Marriott Columbia - Columbia
+1-888-965-1860
1100 Woodland Springs Court, Columbia, MO 65202 ~36.30 miles west of 65280
  • Affordable Suburban hotel
  • 4 floors in property
From$80
Very Good 4.0 /5 Read Reviews Call BookMore Details
Candlewood Suites Columbia East by IHG : 1400 Creekwood Pkwy.
+1-888-788-5576
1400 Creekwood Pkwy., Columbia, MO 65202 ~36.37 miles west of 65280
  • Low priced Suburban property
  • 4 floors in property
From$55
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Fairfield Inn & Suites Columbia
+1-888-897-9207
1115 Woodland Springs Court, Columbia, MO 65202 ~36.38 miles west of 65280
  • Midscale Highway property
  • Check in: 3:00
From$80
Average 3.0 /5 Hotel Reviews Call BookMore Details
Hampton Inn Columbia - Columbia
+1-888-311-4278
3410 Clark Lane, Columbia, MO 65202 ~36.44 miles west of 65280
  • Affordable Highway hotel
  • Check-in: 3:00PM
From$99
Very Good 4.5 /5 Reviews Call BookMore Details
Motel 6 Columbia East Mo in Columbia
+1-888-469-4795
3402 Interstate 70 Dr. Southeast, Columbia, MO 65201 ~36.44 miles west of 65280
  • Inexpensive hotel
  • Check-in time: 15:00
From$60
Very Good 4.0 /5 Reviews Call BookMore Details
Super 8 by Wyndham Columbia Clark Lane
+1-888-734-9421
3216 Clark Lane, Columbia, MO 65202 ~36.53 miles west of 65280
  • 2-star Highway property
  • Check-in time: 11:00 AM
Staybridge Suites Columbia by IHG
+1-888-841-5292
805 Keene St., Columbia, MO 65201 ~36.60 miles west of 65280
  • 3-star Suburban property
  • Hotel has 4 floors
From$66
Very Good 4.5 /5 Guest Reviews Call BookMore Details
Quality Inn & Suites Columbia I-70
+1-888-455-5160
801 Keene St., Columbia, MO 65201 ~36.60 miles west of 65280
  • Cheap Downtown property
  • Hotel has 2 floors
From$60
Average 3.0 /5 Latest Reviews Call BookMore Details
Howard Johnson Inn Columbia : 3100 I 70 Dr. Southeast
+1-888-965-8297
3100 I 70 Dr. Southeast, Columbia, MO 65201 ~36.62 miles west of 65280
  • 2-star Highway property
  • Free complimentary breakfast
From$60
Average 3.0 /5 Reviews Call BookMore Details
Drury Plaza Hotel Columbia East - Columbia
+1-888-906-6358
3100 Interstate 70 Dr. Se, Columbia, MO 65201 ~36.63 miles west of 65280
  • 3-star Suburban property
  • Hotel has 210 rooms
From$136
Average 3.0 /5 Reviews Call BookMore Details
Country Inn & Suites by Radisson, Columbia, MO in Columbia
+1-888-749-6785
817 North Keene St., Columbia, MO 65201 ~36.67 miles west of 65280
  • Three Star Highway property
  • Check-in time: 03:00 PM
From$80
Very Good 4.5 /5 Hotel Reviews Call BookMore Details
Quality Inn & Suites Columbia I-70
+1-888-878-9982
801 North Keene St., Columbia, MO 65201 ~36.71 miles west of 65280
  • 3 star Downtown hotel
  • Free breakfast
From$52
Average 3.5 /5 Review Score Call BookMore Details
Best Western Plus Columbia Inn
+1-888-389-4485
2904 Clark Ln, Columbia, MO 65202 ~36.74 miles west of 65280
  • 2-star Suburban hotel
  • 76 rooms in property
From$80
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Wingate by Wyndham - Columbia - Columbia
+1-888-389-4121
3101 Wingate Court, Columbia, MO 65201 ~36.78 miles west of 65280
  • Affordable Highway property
  • Check-in time: 3 pm
From$89
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Ramada by Wyndham Columbia
+1-888-675-2083
901 Conley Rd., Columbia, MO 65201 ~36.83 miles west of 65280
  • Two-star Highway property
  • Free comp. breakfast
From$54
Average 3.5 /5 Latest Reviews Call BookMore Details
Baymont by Wyndham Hannibal
+1-800-716-8490
4141 Market St., Hannibal, MO 63401 ~37.02 miles northeast of 65280
  • Two-star Convention Center hotel
  • Check in time: 2:00 PM
From$35
Average 3.0 /5 Recent Reviews Call BookMore Details
Days Inn by Wyndham Hannibal : 4070 Market St.
+1-800-805-5223
4070 Market St., Hannibal, MO 63401 ~37.06 miles northeast of 65280
  • Low-priced property
  • Check in: 15:00
From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
Comfort Inn & Suites - Hannibal - Hannibal
+1-888-965-1860
4000 Market St., Hannibal, MO 63401 ~37.10 miles northeast of 65280
  • Cheap Highway hotel
  • Hotel has an eco-friendly policy See policy
From$75
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Holiday Inn Express Hotel & Suites Columbia Univ Area-Hwy 63 by I
+1-888-788-5576
1402 Cinnamon Hill Lane, Columbia, MO 65201 ~37.59 miles west of 65280
  • Three Star Highway hotel
  • Hotel has a green policy See policy
From$80
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Budget Host Inn in Columbia
+1-888-897-9207
900 Vandiver Dr., Columbia, MO 65202 ~38.13 miles west of 65280
  • Cheap Highway property
  • Complimentary breakfast is offered
From$40
Average 3.0 /5 Reviews Call BookMore Details
Motel 6 Hannibal, MO - Hannibal
+1-888-311-4278
123 Huckleberry Heights Dr., Hannibal, MO 63401 ~38.16 miles northeast of 65280
  • Cheap property
  • Check in time: 14:00
From$60
Average 3.5 /5 Reviews Call BookMore Details
Super 8 by Wyndham Hannibal : 120 Huckleberry Heights Dr.
+1-888-469-4795
120 Huckleberry Heights Dr., Hannibal, MO 63401 ~38.21 miles northeast of 65280
  • Two star Highway property
  • Free breakfast
From$60
Average 3.0 /5 Reviews Call BookMore Details
Sleep Inn & Suites : 105 Lakeside Dr.
+1-888-734-9421
105 Lakeside Dr., Hannibal, MO 63401 ~38.23 miles north of 65280
  • Cheap property
  • Check in time: 3:00
From$109
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Courtyard by Marriott Columbia Missouri - Columbia
+1-888-841-5292
3301 Lemone Industrial Blvd., Columbia, MO 65201 ~38.29 miles southwest of 65280
  • 3 star Highway property
  • 11 meeting rooms in property
From$99
Very Good 4.5 /5 Guest Reviews Call BookMore Details
Baymont by Wyndham Warrenton - Warrenton
+1-888-455-5160
425 East Veterans Memorial Pkwy., Warrenton, MO 63383 ~38.55 miles southeast of 65280
  • Low priced Rural property
  • 7 suites in property
From$60
Average 3.0 /5 Recent Reviews Call BookMore Details
TownePlace Suites by Marriott Columbia - Columbia
+1-888-965-8297
4400 Nocona Pkwy., Columbia, MO 65201 ~38.55 miles southwest of 65280
  • Affordable property
  • Comp. Breakfast
From$85
Average 3.0 /5 Recent Reviews Call BookMore Details
Quality Inn & Suites Hannibal
+1-888-906-6358
120 Lindsey Dr., Hannibal, MO 63401 ~38.55 miles north of 65280
  • Affordable property
  • 17 suites in property
From$67
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Red Roof Inn Columbia, MO
+1-888-749-6785
201 East Texas Ave., Columbia, MO 65202 ~38.57 miles west of 65280
  • 3-star Suburban property
  • 108 rooms in property
From$44
Average 3.0 /5 Hotel Reviews Call BookMore Details
The Broadway Columbia a Doubletree by Hilton
+1-888-878-9982
1111 East Broadway, Columbia, MO 65201 ~38.59 miles west of 65280
  • 4-star Downtown property
  • Fitness + Health Center
From$143
Very Good 4.0 /5 Recent Reviews Call BookMore Details

Next: Show All Available 65280 Hotels with Pricing

Graph: Upcoming 20 Days of 65280 Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Mexico, MO discounts available. The chart reflects the cheapest Mexico hotel for each day and each star rating category.

FAQs about hotels near 65280

What are the top rated hotels near 65280?

Hampton Inn Columbia, Staybridge Suites Columbia by IHG and Country Inn & Suites by Radisson, Columbia, MO are the best rated hotels based on customer reviews in the last 365 days.

What are the most high-end hotels near 65280?

The Broadway Columbia a Doubletree by Hilton, Best Western Teal Lake Inn and Country Hearth Inn & Suites Mexico are the top 3 luxury hotels near 65280.

What hotels are closest to the area of 65280?

America's Value Inn Mexico, Days Inn by Wyndham Mexico, and Best Western Teal Lake Inn are the properties closest to 65280.

How much does a cheap hotel near 65280 cost per night?

In the last year, a 2 star hotel near 65280 can be as cheap as $63.47 per night. (based on HotelPlanner prices)

How much does a 3 star hotel near 65280 cost per night?

In the last year, the average 3 star hotel near 65280 has been $98.83 per night. (based on HotelPlanner prices)

How much does a higher-end hotel near 65280 cost?

In the last year, the average 4 star hotel near 65280 has been $160.00 per night. (based on HotelPlanner prices)

What are the best independent hotels near 65280?

America's Value Inn Mexico, America's Best Inn New Florence and Motel 70 are the best rated independent hotels (not part of a big brand).

What are the best Marriott hotels near 65280?

Courtyard by Marriott Columbia Missouri, Residence Inn by Marriott Columbia and Springhill Suites by Marriott Columbia are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the best Choice Hotels branded hotels near 65280?

Comfort Inn & Suites - Hannibal, Sleep Inn & Suites and Quality Inn & Suites Hannibal are the best rated Choice Hotels branded hotels (based on HotelPlanner reviews score).

What are the best Best Western hotels near 65280?

Best Western Teal Lake Inn and Best Western Plus Columbia Inn are the best rated Best Western branded hotels (based on user reviews score).

What are the most popular IHG hotels near 65280?

Staybridge Suites Columbia by IHG, Holiday Inn Express & Suites Kingdom City by IHG and Candlewood Suites Columbia East by IHG are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

Back to Top