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65280 Hotels/Motels & Accommodations

America's Value Inn Mexico
+1-888-389-4121
4224 South Clark St., Mexico, MO 65265 ~11.57 miles west of 65280
  • 2-star Airport hotel
  • Free breakfast available
From$35
Very good 4.0 /5 Hotel Reviews Call BookMore Details
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Days Inn by Wyndham Mexico : 2902 South Clark
+1-888-675-2083
2902 South Clark, Mexico, MO 65265 ~11.64 miles west of 65280
  • 2 star Suburban property
  • Fitness + Health Center
From$60
Average 3.0 /5 Read Reviews Call BookMore Details
Best Western Teal Lake Inn
+1-800-716-8490
3602 South Clark St., Mexico, MO 65265 ~12.14 miles west of 65280
  • Three Star Suburban hotel
  • 2 suites in hotel
From$63
Very good 4.0 /5 Reviews Call BookMore Details
Country Hearth Inn & Suites Mexico
+1-800-805-5223
900 Vance Rd., Mexico, MO 65265 ~12.88 miles west of 65280
  • Three Star Highway hotel
  • 5 suites in property
From$44
Average 3.5 /5 Review Score Call BookMore Details
Baymont by Wyndham - Kingdom City
+1-888-965-1860
5750 Jade Rd., Kingdom City, MO 65262 ~22.04 miles southwest of 65280
  • Two-star hotel
  • 3 floors in hotel
From$73
Average 3.0 /5 Read Reviews Call BookMore Details
Super 8 by Wyndham Kingdom City
+1-888-788-5576
3370 Gold Ave., Kingdom City, MO 65262 ~22.51 miles southwest of 65280
  • Low priced Suburban hotel
  • Hotel has an eco-friendly policy Read more
From$60
Average 3.0 /5 Latest Reviews Call BookMore Details
Quality Inn Kingdom City I-70
+1-888-897-9207
3207 County Rd. 211, Kingdom City, MO 65262 ~22.52 miles southwest of 65280
  • Mid-scale Highway hotel
  • Fitness / Gym is on-site
From$80
Average 3.0 /5 Latest Reviews Call BookMore Details
Holiday Inn Express & Suites Kingdom City by IHG : 3257 County Rd. 211
+1-888-311-4278
3257 County Rd. 211, Kingdom City, MO 65262 ~22.59 miles southwest of 65280
  • Two-star hotel
  • Check in: 15:00
From$60
Very good 4.0 /5 Recent Reviews Call BookMore Details
Days Inn by Wyndham Kingdom City : 3391 County Rd. 211
+1-888-469-4795
3391 County Rd. 211, Kingdom City, MO 65262 ~22.64 miles southwest of 65280
  • Economical Highway hotel
  • 2 floors in hotel
From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
Americas Best Value Inn New Florence in New Florence
+1-888-734-9421
202 Clark Dr., New Florence, MO 63363 ~23.00 miles southeast of 65280
  • Cheap hotel
  • Hotel has 47 rooms
Knights Inn New Florence
+1-888-841-5292
403 Booneslick Rd., New Florence, MO 63363 ~23.07 miles southeast of 65280
  • 2-star hotel
From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
America's Best Inn New Florence - New Florence
+1-888-455-5160
1 Proactive Dr., New Florence, MO 63363 ~23.32 miles southeast of 65280
  • Two star property
From$60
Very good 4.0 /5 Latest Reviews Call BookMore Details
Baymont by Wyndham Fulton : 2205 Cardinal Dr.
+1-888-965-8297
2205 Cardinal Dr., Fulton, MO 65251 ~26.72 miles southwest of 65280
  • 3 star Rural hotel
  • Check in time: 3:00 PM
From$60
Very good 4.0 /5 Guest Reviews Call BookMore Details
Motel 70
+1-888-906-6358
930 Tree Farm Rd., High Hill, MO 65330 ~27.22 miles southeast of 65280
  • Two star property
  • Hotel has 13 rooms
From$30
Very good 4.0 /5 Latest Reviews Call BookMore Details
Super 8 by Wyndham Bowling Green
+1-888-749-6785
1216 East Champ Clark Dr., Bowling Green, MO 63334 ~28.24 miles east of 65280
  • Two star Rural hotel
  • Check-in: 2:00 PM
From$56
Very good 4.0 /5 Recent Reviews Call BookMore Details
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Capital O Amerihost Inn and Suites Fulton Hwy 54 MO
+1-888-878-9982
556 Amerihost Dr., Fulton, MO 65251 ~28.59 miles southwest of 65280
  • Two-star Highway property
  • 2 floors in hotel
From$60
Very good 4.0 /5 Recent Reviews Call BookMore Details
FairBridge Inn Express, Monroe City in Monroe City
+1-888-389-4485
3 Gateway Sq. Dr., Monroe City, MO 63456 ~32.27 miles north of 65280
  • Economical Suburban hotel
  • Comp. Breakfast
From$60
Average 3.0 /5 Hotel Reviews Call BookMore Details
Super 8 by Wyndham Columbia East
+1-888-389-4121
5700 Freedom Dr., Columbia, MO 65202 ~34.66 miles west of 65280
  • Low Cost Highway property
  • Check in time: 2 P.M.
From$60
Average 3.0 /5 Reviews Call BookMore Details
Holiday Inn Columbia East An Ihg Hotel
+1-888-675-2083
915 Port Way, Columbia, MO 65201 ~34.83 miles west of 65280
  • Economy Suburban property
  • Gym is available on property
From$60
Average 3.0 /5 Read Reviews Call BookMore Details
Hilton Garden Inn Columbia in Columbia
+1-800-716-8490
3300 Vandiver Dr., Columbia, MO 65202 ~36.10 miles west of 65280
  • 3 star Suburban property
  • 151 rooms in property
From$93
Very good 4.0 /5 Latest Reviews Call BookMore Details
Springhill Suites by Marriott Columbia : 3415 Clark Lane
+1-800-805-5223
3415 Clark Lane, Columbia, MO 65202 ~36.19 miles west of 65280
  • Midscale Highway property
  • Check-in time: 3:00 PM
From$129
Average 3.0 /5 Review Score Call BookMore Details
Residence Inn by Marriott Columbia
+1-888-965-1860
1100 Woodland Springs Court, Columbia, MO 65202 ~36.20 miles west of 65280
  • Mid-scale Suburban hotel
  • Hotel has a green policy See policy
From$80
Very good 4.0 /5 Read Reviews Call BookMore Details
Candlewood Suites Columbia East by IHG
+1-888-788-5576
1400 Creekwood Pkwy., Columbia, MO 65202 ~36.27 miles west of 65280
  • 2-star Suburban hotel
  • 96 suites in property
From$55
Very good 4.0 /5 Read Reviews Call BookMore Details
Fairfield Inn & Suites by Marriott Columbia in Columbia
+1-888-897-9207
1115 Woodland Springs Court, Columbia, MO 65202 ~36.27 miles west of 65280
  • Affordable Highway property
  • Hotel has 23 suites
From$80
Average 3.0 /5 Read Reviews Call BookMore Details
Hampton Inn Columbia : 3410 Clark Lane
+1-888-311-4278
3410 Clark Lane, Columbia, MO 65202 ~36.34 miles west of 65280
  • Three Star Highway property
  • Hotel has 120 rooms
From$99
Very good 4.5 /5 Guest Reviews Call BookMore Details
Motel 6 Columbia East Mo : 3402 Interstate 70 Dr. Southeast
+1-888-469-4795
3402 Interstate 70 Dr. Southeast, Columbia, MO 65201 ~36.34 miles west of 65280
  • Economy hotel
From$60
Very good 4.0 /5 Reviews Call BookMore Details
Super 8 by Wyndham Columbia Clark Lane : 3216 Clark Lane
+1-888-734-9421
3216 Clark Lane, Columbia, MO 65202 ~36.43 miles west of 65280
  • Economical Highway hotel
  • 73 rooms in property
From$60
Poor 2.0 /5 Reviews Call BookMore Details
Quality Inn & Suites Columbia I-70
+1-888-841-5292
801 Keene St., Columbia, MO 65201 ~36.49 miles west of 65280
  • Economical Downtown property
  • Hotel has 3 suites
From$60
Average 3.0 /5 Reviews Call BookMore Details
Staybridge Suites Columbia by IHG
+1-888-455-5160
805 Keene St., Columbia, MO 65201 ~36.49 miles west of 65280
  • 3-star Suburban property
  • Check in time: 3:00pm
From$66
Very good 4.5 /5 Reviews Call BookMore Details
Howard Johnson Inn Columbia - Columbia
+1-888-965-8297
3100 I 70 Dr. Southeast, Columbia, MO 65201 ~36.52 miles west of 65280
  • Economical Highway property
  • Fitness center on property
From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
Country Inn & Suites by Radisson, Columbia, MO
+1-888-906-6358
817 North Keene St., Columbia, MO 65201 ~36.57 miles west of 65280
  • 3 star Highway property
  • 85 rooms in hotel
From$80
Very good 4.5 /5 Hotel Reviews Call BookMore Details
Quality Inn & Suites Columbia I-70 in Columbia
+1-888-749-6785
801 North Keene St., Columbia, MO 65201 ~36.60 miles west of 65280
  • 3-star Downtown hotel
  • Free breakfast
From$52
Average 3.5 /5 Read Reviews Call BookMore Details
Best Western Plus Columbia Inn
+1-888-878-9982
2904 Clark Ln, Columbia, MO 65202 ~36.64 miles west of 65280
  • Economy Suburban hotel
  • Check in time: 3.00 pm
From$80
Very good 4.0 /5 Latest Reviews Call BookMore Details
Wingate by Wyndham - Columbia in Columbia
+1-888-389-4485
3101 Wingate Court, Columbia, MO 65201 ~36.67 miles west of 65280
  • 3-star Highway hotel
  • Fitness / Gym is on-site
From$89
Very good 4.0 /5 Guest Reviews Call BookMore Details
Ramada by Wyndham Columbia in Columbia
+1-888-389-4121
901 Conley Rd., Columbia, MO 65201 ~36.72 miles west of 65280
  • Cheap Highway property
  • 28 suites in property
From$54
Average 3.5 /5 Review Score Call BookMore Details
Baymont by Wyndham Hannibal : 4141 Market St.
+1-888-675-2083
4141 Market St., Hannibal, MO 63401 ~36.99 miles northeast of 65280
  • Low Cost Convention Center property
  • 5 meeting rooms in hotel
From$35
Average 3.0 /5 Guest Reviews Call BookMore Details
Days Inn by Wyndham Hannibal
+1-800-716-8490
4070 Market St., Hannibal, MO 63401 ~37.03 miles northeast of 65280
  • Low Cost property
  • 2 floors in property
From$60
Average 3.0 /5 Reviews Call BookMore Details
Comfort Inn & Suites - Hannibal
+1-800-805-5223
4000 Market St., Hannibal, MO 63401 ~37.07 miles northeast of 65280
  • 2 star Highway hotel
  • Check in time: 3:00 PM
From$75
Very good 4.0 /5 Read Reviews Call BookMore Details
Holiday Inn Express Hotel & Suites Columbia Univ Area-Hwy 63 by I : 1402 Cinnamon Hill Lane
+1-888-965-1860
1402 Cinnamon Hill Lane, Columbia, MO 65201 ~37.49 miles west of 65280
  • Affordable Highway property
  • Has environment-friendly policy See more
From$80
Very good 4.0 /5 Guest Reviews Call BookMore Details
Budget Host Inn
+1-888-788-5576
900 Vandiver Dr., Columbia, MO 65202 ~38.03 miles west of 65280
  • 2-star Highway property
  • Free comp. breakfast
From$40
Average 3.0 /5 Latest Reviews Call BookMore Details
Motel 6 Hannibal, MO - Hannibal
+1-888-897-9207
123 Huckleberry Heights Dr., Hannibal, MO 63401 ~38.13 miles northeast of 65280
  • Economy hotel
  • Check-in: 14:00
From$60
Average 3.5 /5 Recent Reviews Call BookMore Details
Courtyard by Marriott Columbia Missouri : 3301 Lemone Industrial Blvd.
+1-888-311-4278
3301 Lemone Industrial Blvd., Columbia, MO 65201 ~38.17 miles southwest of 65280
  • Three Star Highway property
  • Hotel has 11 meeting rooms
From$99
Very good 4.5 /5 Reviews Call BookMore Details
Super 8 by Wyndham Hannibal in Hannibal
+1-888-469-4795
120 Huckleberry Heights Dr., Hannibal, MO 63401 ~38.18 miles northeast of 65280
  • Low priced Highway hotel
  • Hotel has 57 rooms
From$60
Average 3.0 /5 Hotel Reviews Call BookMore Details
Sleep Inn & Suites Hannibal West
+1-888-734-9421
105 Lakeside Dr., Hannibal, MO 63401 ~38.19 miles north of 65280
  • Cheap property
  • Free complimentary breakfast
From$109
Very good 4.0 /5 Review Score Call BookMore Details
Towneplace Suites by Marriott Columbia
+1-888-841-5292
4400 Nocona Pkwy., Columbia, MO 65201 ~38.43 miles southwest of 65280
  • Affordable hotel
  • Hotel has 99 suites
From$85
Average 3.0 /5 Reviews Call BookMore Details
Baymont by Wyndham Warrenton - Warrenton
+1-888-455-5160
425 East Veterans Memorial Pkwy., Warrenton, MO 63383 ~38.43 miles southeast of 65280
  • Economy Rural hotel
  • Free breakfast
From$60
Average 3.0 /5 Latest Reviews Call BookMore Details
Red Roof Inn Columbia, MO - Columbia
+1-888-965-8297
201 East Texas Ave., Columbia, MO 65202 ~38.46 miles west of 65280
  • Mid-scale Suburban hotel
  • 2 floors in property
From$44
Average 3.0 /5 Recent Reviews Call BookMore Details
The Broadway Columbia a Doubletree by Hilton
+1-888-906-6358
1111 East Broadway, Columbia, MO 65201 ~38.48 miles west of 65280
  • Expensive Downtown property
  • Airport shuttle available
From$143
Very good 4.0 /5 Read Reviews Call BookMore Details
Quality Inn & Suites Hannibal West in Hannibal
+1-888-749-6785
120 Lindsey Dr., Hannibal, MO 63401 ~38.51 miles north of 65280
  • 3 star property
  • Gym is available on property
From$67
Very good 4.0 /5 Review Score Call BookMore Details
Holiday Inn Express Warrenton by IHG - Warrenton
+1-888-878-9982
1008 North Highway 47, Warrenton, MO 63383 ~38.54 miles southeast of 65280
  • Economical Suburban property
  • Gym is available on property
From$105
Very good 4.0 /5 Recent Reviews Call BookMore Details

Next: Show All Available 65280 Hotels with Pricing

Graph: Upcoming 20 Days of 65280 Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Mexico, MO discounts available. The chart reflects the cheapest Mexico hotel for each day and each star rating category.

FAQs about hotels near 65280

What are the top rated hotels near 65280?

Hampton Inn Columbia, Staybridge Suites Columbia by IHG and Country Inn & Suites by Radisson, Columbia, MO are the best rated hotels based on customer reviews in the last 365 days.

What are the most high-end hotels near 65280?

The Broadway Columbia a Doubletree by Hilton, Best Western Teal Lake Inn and Country Hearth Inn & Suites Mexico are the top 3 luxury hotels near 65280.

What hotels are closest to the area of 65280?

America's Value Inn Mexico, Days Inn by Wyndham Mexico, and Best Western Teal Lake Inn are the properties closest to 65280.

How much does a cheap hotel near 65280 cost per night?

In the last year, a 2 star hotel near 65280 can be as cheap as $63.47 per night. (based on HotelPlanner prices)

How much does a 3 star hotel near 65280 cost per night?

In the last year, the average 3 star hotel near 65280 has been $98.83 per night. (based on HotelPlanner prices)

How much does a higher-end hotel near 65280 cost?

In the last year, the average 4 star hotel near 65280 has been $160.00 per night. (based on HotelPlanner prices)

What are the best independent hotels near 65280?

America's Value Inn Mexico, America's Best Inn New Florence and Motel 70 are the best rated independent hotels (not part of a big brand).

What are the best Marriott hotels near 65280?

Courtyard by Marriott Columbia Missouri, Residence Inn by Marriott Columbia and Springhill Suites by Marriott Columbia are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the best Choice Hotels branded hotels near 65280?

Comfort Inn & Suites - Hannibal, Sleep Inn & Suites Hannibal West and Quality Inn & Suites Hannibal West are the best rated Choice Hotels branded hotels (based on HotelPlanner reviews score).

What are the best Best Western hotels near 65280?

Best Western Teal Lake Inn and Best Western Plus Columbia Inn are the best rated Best Western branded hotels (based on user reviews score).

What are the most popular IHG hotels near 65280?

Staybridge Suites Columbia by IHG, Holiday Inn Express & Suites Kingdom City by IHG and Candlewood Suites Columbia East by IHG are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

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