Hotels in 78221 - San Antonio TX

Only hotels in 78221 zip code are listed below. Search for cheap and discount hotel rates in San Antonio, TX for your upcoming leisure or conference / group travel. We list the best 78221 hotels and motels so you can review the San Antonio hotel list below to find the perfect lodging. Hotels in Bexar county and area code 210 are also listed.

78221 Hotels/Motels & Accommodations

Holiday Inn Express & Suites San Antonio South 410 in San Antonio 11400 SE Loop 410 Acc Rd., San Antonio, TX 78221 Call
  • 3 star Suburban hotel
  • 80 sleeping rooms in hotel
More Photos
From$96 total
Average 3.0 /5 Hotel Reviews Call BookMore Details
Best Western Plus Palo Alto Inn & Suites 12507 SW Loop 410, San Antonio, TX 78224 Call ~4.14 miles northwest of 78221
  • 3-star hotel
  • 32 suites in hotel
More Photos
From$68 total
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Days Inn by Wyndham San Antonio at Palo Alto in San Antonio 9403 Poteet Jourdanton Freeway, San Antonio, TX 78224 Call ~4.59 miles northwest of 78221
  • Economy Downtown hotel
  • Check-in: 11:00 AM
More Photos
From$72 total
Average 3.0 /5 Read Reviews Call BookMore Details
Woodspring Suites San Antonio South - San Antonio 7958 Interstate 35 Access Rd., San Antonio, TX 78224 Call ~5.58 miles north of 78221
  • 2-star Highway property
  • Hotel has 4 floors
More Photos
From$51 total
Average 3.0 /5 Latest Reviews Call BookMore Details
Baymont by Wyndham San Antonio South Park 7202 South Pan Am Expressway, San Antonio, TX 78224 Call ~5.95 miles north of 78221
  • Affordable Highway property
  • Hotel has 2 floors
More Photos
From$96 total
Poor 2.0 /5 Recent Reviews Call BookMore Details
Motel 6 San Antonio, TX - South : 7950 South Panam Expy 7950 South Panam Expy, San Antonio, TX 78224 Call ~6.30 miles north of 78221
  • 2 star hotel
  • 75 rooms in hotel
More Photos
From$72 total
Poor 2.5 /5 Latest Reviews Call BookMore Details
Embassy Suites by Hilton San Antonio Brooks Hotel & Spa - San Antonio 7610 South New Braunfels, San Antonio, TX 78235 Call ~6.86 miles northeast of 78221
  • 4 star Downtown hotel
  • Check-in: 4:00pm
More Photos
From$150 total
Average 3.0 /5 Read Reviews Call BookMore Details
Best Western Plus Elmendorf Hotel / San Antonio Hotel : 20015 Eagle Ford Way 20015 Eagle Ford Way, Elmendorf, TX 78112 Call ~6.94 miles east of 78221
  • 3 star Highway hotel
  • 9 suites in hotel
More Photos
From$96 total
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Holiday Inn Express & Suites San Antonio Brooks Cb - San Antonio 8222 City Base Landing, San Antonio, TX 78235 Call ~7.26 miles northeast of 78221
  • Midscale Suburban hotel
  • 35 suites in property
More Photos
From$62 total
Average 3.0 /5 Guest Reviews Call BookMore Details
Hampton Inn & Suites San Antonio City Base Landing - San Antonio 8202 City Base Landing, San Antonio, TX 78235 Call ~7.38 miles northeast of 78221
  • 3-star Suburban property
  • Comp. Breakfast
More Photos
From$81 total
Very Good 4.0 /5 Reviews Call BookMore Details
La Quinta Inn by Wyndham San Antonio Brooks City Base in San Antonio 3180 Goliad Rd., San Antonio, TX 78223 Call ~7.54 miles northeast of 78221
  • 2 star Suburban hotel
  • Access to gym on-site
More Photos
From$74 total
Average 3.0 /5 Review Score Call BookMore Details
Econo Lodge San Antonio South 606 Division Ave., San Antonio, TX 78214 Call ~7.58 miles north of 78221
  • Low priced property
  • Hotel has 69 rooms
More Photos
From$72 total
Poor 2.0 /5 Guest Reviews Call BookMore Details
Fairfield Inn & Suites San Antonio Brooks City Base 3234 Goliad Rd., San Antonio, TX 78223 Call ~7.60 miles northeast of 78221
  • Three Star Suburban property
  • Hotel has 17 suites
More Photos
From$73 total
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Motel 6 San Antonio, TX - Downtown - Alamo Dome 748 Hot Wells Blvd., San Antonio, TX 78223 Call ~7.74 miles northeast of 78221
  • Inexpensive Downtown hotel
  • Check in: 400pm
More Photos
From$36 total
Poor 2.5 /5 Guest Reviews Call BookMore Details
Super 8 by Wyndham San Antonio/Alamodome Area 723 Hot Wells, San Antonio, TX 78223 Call ~7.77 miles northeast of 78221
  • Economy Downtown hotel
  • Gym is available on property
More Photos
From$72 total
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Quality Suites San Antonio Brooks City Base 3602 SE Military Dr., San Antonio, TX 78223 Call ~7.88 miles northeast of 78221
  • 3-star Suburban hotel
  • Check in: 3:00pm
More Photos
From$58 total
Average 3.0 /5 Review Score Call BookMore Details
Econo Lodge Inn & Suites 120 Rustleaf Dr., San Antonio, TX 78242 Call ~8.75 miles northwest of 78221
  • Economical hotel
  • Check in: 11:00 AM
More Photos
From$72 total
Average 3.0 /5 Reviews Call BookMore Details
Econo Lodge Inn & Suites Near Lackland AFB Rustleaf & SW Military Dr., San Antonio, TX 78242 Call ~8.77 miles northwest of 78221
  • 2 star property
  • 32 sleeping rooms in hotel
More Photos
From$72 total
Average 3.0 /5 Review Score Call BookMore Details
Stay Nixon 423 Blue Star, San Antonio, TX 78204 Call ~9.44 miles north of 78221
  • High end Downtown hotel
  • Check in time: 3:00 pm
More Photos
From$118 total
Average 3.0 /5 Read Reviews Call BookMore Details
Sonder Southtown Suites : 111 Probandt St. 111 Probandt St., San Antonio, TX 78204 Call ~9.56 miles north of 78221
  • Four star Downtown property
  • 5 floors in property
More Photos
From$90 total
Average 3.0 /5 Reviews Call BookMore Details
The Inn at Market Square 1500 I 35 South Exit 154b Laredo St., San Antonio, TX 78204 Call ~9.73 miles north of 78221
  • Low-priced Downtown hotel
  • Check-in time: 3:00 P.M.
More Photos
From$42 total
Poor 2.0 /5 Review Score Call BookMore Details
Days Inn & Suites by Wyndham Braunig Lake - Elmendorf 13800 Ih 37 South, Elmendorf, TX 78112 Call ~9.88 miles east of 78221
  • Low Cost Lake hotel
  • 2 floors in property
More Photos
From$70 total
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Econo Lodge Inn & Suites Downtown San Antonio Riverwalk Area : 1122 South Laredo St. 1122 South Laredo St., San Antonio, TX 78204 Call ~10.04 miles north of 78221
  • Cheap Downtown property
  • Free breakfast
More Photos
From$36 total
Not Good 1.5 /5 Hotel Reviews Call BookMore Details
Super 8 by Wyndham San Antonio/Riverwalk Area 302 Roland Ave., San Antonio, TX 78210 Call ~10.06 miles north of 78221
  • Low-priced Downtown hotel
  • Hotel has 55 rooms
More Photos
From$72 total
Average 3.0 /5 Latest Reviews Call BookMore Details
Candlewood Suites San Antonio Downtown An Ihg Hotel 1024 South Laredo St., San Antonio, TX 78204 Call ~10.07 miles north of 78221
  • Cheap Downtown hotel
  • Access to gym on-site
More Photos
From$108 total
Average 3.0 /5 Guest Reviews Call BookMore Details
Days Inn by Wyndham San Antonio Downtown 1025 South Frio St., San Antonio, TX 78207 Call ~10.10 miles north of 78221
  • Economical Downtown property
  • Check in: 11:00 am
More Photos
From$72 total
Very Good 4.0 /5 Review Score Call BookMore Details
Best Western Alamo Suites in San Antonio 1002 South Laredo St., San Antonio, TX 78204 Call ~10.13 miles north of 78221
  • Affordable Downtown property
  • 3 floors in hotel
More Photos
From$90 total
Very Good 4.0 /5 Review Score Call BookMore Details
Best Western Plus Roland Inn & Suites - San Antonio 333 Roland Ave., San Antonio, TX 78210 Call ~10.18 miles north of 78221
  • Midscale property
  • 4 floors in property
More Photos
From$68 total
Very Good 4.0 /5 Read Reviews Call BookMore Details
River Inn Motel 909 South Frio St., San Antonio, TX 78207 Call ~10.19 miles north of 78221
  • Two star Downtown hotel
  • Check-in: 3:00PM
More Photos
From$72 total
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Holiday Inn Express & Suites San Antonio Dtwn Market Area 102 El Paso St., San Antonio, TX 78204 Call ~10.25 miles north of 78221
  • Low priced Downtown hotel
  • Hotel has a green policy Learn more
More Photos
From$78 total
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Residence Inn San Antonio Market Square Downtown in San Antonio 628 South Santa Rosa Ave., San Antonio, TX 78204 Call ~10.38 miles north of 78221
  • 3-star Downtown property
  • Fitness center on property
More Photos
From$96 total
Average 3.0 /5 Reviews Call BookMore Details
Sonder La Villita 633 South St. Mary's St., San Antonio, TX 78205 Call ~10.39 miles north of 78221
  • Expensive Downtown property
  • 17 rooms in hotel
More Photos
From$90 total
Average 3.0 /5 Read Reviews Call BookMore Details
Fairfield Inn & Suites San Antonio Downtown / Market Square : 620 South Santa Rosa Ave. 620 South Santa Rosa Ave., San Antonio, TX 78204 Call ~10.40 miles north of 78221
  • Midscale Downtown hotel
  • Check-in time: 03:00 PM
More Photos
From$96 total
Average 3.0 /5 Read Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham San Antonio Downtown : 100 West Cesar Chavez Blvd. 100 West Cesar Chavez Blvd., San Antonio, TX 78204 Call ~10.43 miles north of 78221
  • 3 star Downtown hotel
  • Hotel has 151 rooms
More Photos
From$106 total
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Plaza Hotel & Spa San Antonio Autograph Collection 555 South Alamo St., San Antonio, TX 78205 Call ~10.43 miles north of 78221
  • High end Downtown hotel
  • 23 meeting rooms in hotel
More Photos
From$164 total
Average 3.0 /5 Latest Reviews Call BookMore Details
Hyatt Place San Antonio Riverwalk - San Antonio 601 South St. Mary's St., San Antonio, TX 78205 Call ~10.44 miles north of 78221
  • Mid-scale Downtown property
  • 7 floors in hotel
More Photos
From$96 total
Average 3.0 /5 Guest Reviews Call BookMore Details
Hampton Inn & Suites San Antonio-Downtown/Market Square in San Antonio 411 South Flores St., San Antonio, TX 78204 Call ~10.46 miles north of 78221
  • Mid-scale Downtown hotel
  • Free breakfast
More Photos
From$144 total
Average 3.0 /5 Guest Reviews Call BookMore Details
Inn on the Riverwalk 129 Woodward Place, San Antonio, TX 78204 Call ~10.46 miles north of 78221
  • 3 star Downtown hotel
  • 3 floors in property
More Photos
From$142 total
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Courtyard by Marriott San Antonio Downtown/Market Square in San Antonio 600 South Santa Rosa Ave., San Antonio, TX 78204 Call ~10.47 miles north of 78221
  • 3 star Downtown property
  • 137 rooms in property
More Photos
From$142 total
Very Good 4.0 /5 Read Reviews Call BookMore Details
Holiday Inn San Antonio - Dwtn - Market Sq, an IHG Hotel - San Antonio 318 West César East Chávez Blvd., San Antonio, TX 78204 Call ~10.47 miles north of 78221
  • Mid-scale property
  • Check in: 4:00pm
More Photos
From$96 total
Average 3.0 /5 Review Score Call BookMore Details
SpringHill Suites San Antonio Downtown/Riverwalk Area 524 South St. Mary's St., San Antonio, TX 78205 Call ~10.48 miles north of 78221
  • 3 star Convention Center property
  • 116 rooms in hotel
More Photos
From$96 total
Average 3.0 /5 Reviews Call BookMore Details
Holiday Inn Downtown Market Square in San Antonio 318 West Durango Blvd., San Antonio, TX 78204 Call ~10.50 miles north of 78221
  • 3 star Downtown property
  • Fitness + Health Center
More Photos
From$88 total
Average 3.5 /5 Hotel Reviews Call BookMore Details
Holiday Inn San Antonio - Dwtn - Market Sq, an IHG Hotel - San Antonio 318 West Cesar East Chavez Blvd., San Antonio, TX 78204 Call ~10.51 miles north of 78221
  • 3-star Downtown property
  • Hotel has an eco-friendly policy Learn more
More Photos
From$67 total
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Club Wyndham La Cascada : 226 Dwyer Ave. 226 Dwyer Ave., San Antonio, TX 78204 Call ~10.52 miles north of 78221
  • 4-star Downtown hotel
  • Gym is available on property
More Photos
From$102 total
Very Good 4.0 /5 Reviews Call BookMore Details
Fairmount Hotel The Unbound Collection by Hyatt : 401 South Alamo St. 401 South Alamo St., San Antonio, TX 78205 Call ~10.53 miles north of 78221
  • Four star Downtown hotel
  • Hotel has 14 suites
More Photos
From$226 total
Average 3.0 /5 Review Score Call BookMore Details
The Kimpton Santo Riverwalk 431 South Alamo St., San Antonio, TX 78205 Call ~10.54 miles north of 78221
  • 4-star Downtown hotel
  • Gym / Fitness Center Available
More Photos
From$214 total
Average 3.0 /5 Hotel Reviews Call BookMore Details
Doubletree by Hilton San Antonio Downtown - San Antonio 502 West Cesar East Chavez Blvd., San Antonio, TX 78207 Call ~10.55 miles north of 78221
  • 3 star Downtown property
  • Hotel has 22 suites
More Photos
From$80 total
Average 3.0 /5 Reviews Call BookMore Details
Doubletree by Hilton San Antonio Downtown - San Antonio 502 West César East Chávez Blvd., San Antonio, TX 78207 Call ~10.55 miles north of 78221
  • Three Star Downtown hotel
  • 20 suites in hotel
More Photos
From$90 total
Average 3.0 /5 Guest Reviews Call BookMore Details
The O'Brien Riverwalk Hotel, Trademark Collection by Wyndham 116 Navarrro St., San Antonio, TX 78205 Call ~10.58 miles north of 78221
  • Midscale Downtown hotel
  • 3 floors in hotel
More Photos
From$92 total
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Stay Express Inn & Suites 100 Valley Hi Dr., San Antonio, TX 78227 Call ~10.61 miles northwest of 78221
  • Low priced Suburban property
  • 2 floors in property
More Photos
From$44 total
Poor 2.0 /5 Review Score Call BookMore Details
Back to Top