Hotels in 78221 - San Antonio TX

Only hotels in 78221 zip code are listed below. Search for cheap and discount hotel rates in San Antonio, TX for your upcoming leisure or conference / group travel. We list the best 78221 hotels and motels so you can review the San Antonio hotel list below to find the perfect lodging. Hotels in Bexar county and area code 210 are also listed.

78221 Hotels, Motels & Accommodations

Holiday Inn Express & Suites San Antonio South 410 11400 SE Loop 410 Acc Rd., San Antonio, TX 78221 Call
  • 3-star Suburban property
  • Complimentary breakfast is offered
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From$96 total
Average 3.0 /5 Recent Reviews Call BookMore Details
Best Western Plus Palo Alto Inn & Suites in San Antonio 12507 SW Loop 410, San Antonio, TX 78224 Call ~4.14 miles northwest of 78221
  • Midscale hotel
  • 32 suites in property
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From$70 total
Very good 4.0 /5 Review Score Call BookMore Details
Days Inn by Wyndham San Antonio at Palo Alto : 9403 Poteet Jourdanton Freeway 9403 Poteet Jourdanton Freeway, San Antonio, TX 78224 Call ~4.59 miles northwest of 78221
  • 2 star Downtown property
  • Check in: 11:00 AM
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From$72 total
Average 3.0 /5 Read Reviews Call BookMore Details
Woodspring Suites San Antonio South 7958 Interstate 35 Access Rd., San Antonio, TX 78224 Call ~5.58 miles north of 78221
  • 2 star Highway property
  • Check in time: 3:00 PM
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From$51 total
Average 3.0 /5 Latest Reviews Call BookMore Details
Baymont by Wyndham San Antonio South Park : 7202 South Pan Am Expressway 7202 South Pan Am Expressway, San Antonio, TX 78224 Call ~5.95 miles north of 78221
  • Midscale Highway hotel
  • Check in: 3:00pm
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From$96 total
Poor 2.0 /5 Review Score Call BookMore Details
Motel 6 San Antonio, TX - South - San Antonio 7950 South Panam Expy, San Antonio, TX 78224 Call ~6.30 miles north of 78221
  • Low Cost hotel
  • 3 floors in property
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From$72 total
Poor 2.5 /5 Recent Reviews Call BookMore Details
Embassy Suites by Hilton San Antonio Brooks Hotel & Spa 7610 South New Braunfels, San Antonio, TX 78235 Call ~6.86 miles northeast of 78221
  • High end Downtown hotel
  • Hotel has 156 rooms
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From$150 total
Average 3.0 /5 Hotel Reviews Call BookMore Details
Best Western Plus Elmendorf Hotel / San Antonio Hotel 20015 Eagle Ford Way, Elmendorf, TX 78112 Call ~6.94 miles east of 78221
  • 3-star Highway property
  • Hotel has 9 suites
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From$96 total
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Holiday Inn Express & Suites San Antonio Brooks Cb 8222 City Base Landing, San Antonio, TX 78235 Call ~7.26 miles northeast of 78221
  • Midscale Suburban property
  • Hotel has 4 floors
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From$62 total
Average 3.0 /5 Reviews Call BookMore Details
Hampton Inn & Suites San Antonio City Base Landing 8202 City Base Landing, San Antonio, TX 78235 Call ~7.38 miles northeast of 78221
  • Three Star Suburban hotel
  • Check in: 3:00pm
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From$81 total
Very good 4.0 /5 Recent Reviews Call BookMore Details
La Quinta Inn by Wyndham San Antonio Brooks City Base in San Antonio 3180 Goliad Rd., San Antonio, TX 78223 Call ~7.54 miles northeast of 78221
  • Cheap Suburban property
  • Hotel has 115 rooms
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From$74 total
Average 3.0 /5 Hotel Reviews Call BookMore Details
Econo Lodge San Antonio South in San Antonio 606 Division Ave., San Antonio, TX 78214 Call ~7.58 miles north of 78221
  • Low Cost hotel
  • 69 rooms in property
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From$72 total
Poor 2.0 /5 Read Reviews Call BookMore Details
Fairfield Inn & Suites San Antonio Brooks City Base in San Antonio 3234 Goliad Rd., San Antonio, TX 78223 Call ~7.60 miles northeast of 78221
  • 3-star Suburban property
  • 3 floors in property
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From$73 total
Very good 4.0 /5 Recent Reviews Call BookMore Details
Motel 6 San Antonio, TX - Downtown - Alamo Dome 748 Hot Wells Blvd., San Antonio, TX 78223 Call ~7.74 miles northeast of 78221
  • 2-star Downtown property
  • 3 floors in hotel
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From$36 total
Poor 2.5 /5 Recent Reviews Call BookMore Details
Super 8 by Wyndham San Antonio/Alamodome Area 723 Hot Wells, San Antonio, TX 78223 Call ~7.77 miles northeast of 78221
  • Inexpensive Downtown property
  • Gym / Fitness Center Available
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From$72 total
Very good 4.0 /5 Review Score Call BookMore Details
Quality Suites San Antonio Brooks City Base 3602 SE Military Dr., San Antonio, TX 78223 Call ~7.88 miles northeast of 78221
  • 3-star Suburban hotel
  • Free breakfast available
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From$58 total
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Econo Lodge Inn & Suites in San Antonio 120 Rustleaf Dr., San Antonio, TX 78242 Call ~8.75 miles northwest of 78221
  • Economical hotel
  • Check in: 11:00 AM
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From$72 total
Average 3.0 /5 Reviews Call BookMore Details
Econo Lodge Inn & Suites Near Lackland AFB in San Antonio Rustleaf & SW Military Dr., San Antonio, TX 78242 Call ~8.77 miles northwest of 78221
  • Cheap hotel
  • 2 floors in hotel
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From$72 total
Average 3.0 /5 Reviews Call BookMore Details
Stay Nixon 423 Blue Star, San Antonio, TX 78204 Call ~9.44 miles north of 78221
  • High end Downtown property
  • 41 rooms in property
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From$118 total
Average 3.0 /5 Guest Reviews Call BookMore Details
Sonder Southtown Suites 111 Probandt St., San Antonio, TX 78204 Call ~9.56 miles north of 78221
  • Four-star Downtown hotel
  • 5 floors in property
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From$90 total
Average 3.0 /5 Recent Reviews Call BookMore Details
The Inn at Market Square - San Antonio 1500 I 35 South Exit 154b Laredo St., San Antonio, TX 78204 Call ~9.73 miles north of 78221
  • Cheap Downtown hotel
  • Comp. Breakfast
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From$42 total
Poor 2.0 /5 Hotel Reviews Call BookMore Details
Days Inn & Suites by Wyndham Braunig Lake 13800 Ih 37 South, Elmendorf, TX 78112 Call ~9.88 miles east of 78221
  • Cheap Lake property
  • 62 rooms in hotel
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From$70 total
Very good 4.0 /5 Review Score Call BookMore Details
Econo Lodge Inn & Suites Downtown San Antonio Riverwalk Area in San Antonio 1122 South Laredo St., San Antonio, TX 78204 Call ~10.04 miles north of 78221
  • Economy Downtown hotel
  • 50 rooms in property
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From$36 total
Terrible 1.5 /5 Latest Reviews Call BookMore Details
Super 8 by Wyndham San Antonio/Riverwalk Area : 302 Roland Ave. 302 Roland Ave., San Antonio, TX 78210 Call ~10.06 miles north of 78221
  • Two-star Downtown property
  • Check-in time: 3:00pm
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From$72 total
Average 3.0 /5 Guest Reviews Call BookMore Details
Candlewood Suites San Antonio Downtown An Ihg Hotel : 1024 South Laredo St. 1024 South Laredo St., San Antonio, TX 78204 Call ~10.07 miles north of 78221
  • Economical Downtown property
  • Hotel has 96 suites
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From$108 total
Average 3.0 /5 Reviews Call BookMore Details
Days Inn by Wyndham San Antonio Downtown : 1025 South Frio St. 1025 South Frio St., San Antonio, TX 78207 Call ~10.10 miles north of 78221
  • Two star Downtown hotel
  • Comp. Breakfast
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From$72 total
Very good 4.0 /5 Recent Reviews Call BookMore Details
Best Western Alamo Suites 1002 South Laredo St., San Antonio, TX 78204 Call ~10.13 miles north of 78221
  • Mid-scale Downtown property
  • 3 floors in property
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From$90 total
Very good 4.0 /5 Guest Reviews Call BookMore Details
Best Western Plus Roland Inn & Suites in San Antonio 333 Roland Ave., San Antonio, TX 78210 Call ~10.18 miles north of 78221
  • Mid-scale hotel
  • Complimentary breakfast is offered
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From$70 total
Very good 4.0 /5 Guest Reviews Call BookMore Details
River Inn Motel in San Antonio 909 South Frio St., San Antonio, TX 78207 Call ~10.19 miles north of 78221
  • 2 star Downtown hotel
  • Check-in time: 3:00PM
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From$72 total
Very good 4.0 /5 Guest Reviews Call BookMore Details
Holiday Inn Express & Suites San Antonio Dtwn Market Area 102 El Paso St., San Antonio, TX 78204 Call ~10.25 miles north of 78221
  • Cheap Downtown hotel
  • Check-in: 3:00 PM
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From$78 total
Very good 4.0 /5 Read Reviews Call BookMore Details
Residence Inn San Antonio Market Square Downtown - San Antonio 628 South Santa Rosa Ave., San Antonio, TX 78204 Call ~10.38 miles north of 78221
  • 3 star Downtown property
  • 95 suites in hotel
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From$96 total
Average 3.0 /5 Review Score Call BookMore Details
Sonder La Villita 633 South St. Mary's St., San Antonio, TX 78205 Call ~10.39 miles north of 78221
  • 4-star Downtown hotel
  • Access to gym on-site
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From$90 total
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Fairfield Inn & Suites San Antonio Downtown / Market Square - San Antonio 620 South Santa Rosa Ave., San Antonio, TX 78204 Call ~10.40 miles north of 78221
  • Mid-scale Downtown property
  • Hotel has 4 floors
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From$96 total
Average 3.0 /5 Recent Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham San Antonio Downtown 100 West Cesar Chavez Blvd., San Antonio, TX 78204 Call ~10.43 miles north of 78221
  • 3-star Downtown property
  • Free complimentary breakfast
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From$106 total
Very good 4.0 /5 Latest Reviews Call BookMore Details
Plaza Hotel & Spa San Antonio Autograph Collection in San Antonio 555 South Alamo St., San Antonio, TX 78205 Call ~10.43 miles north of 78221
  • Expensive Downtown hotel
  • Hotel has 4 suites
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From$164 total
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Hyatt Place San Antonio Riverwalk in San Antonio 601 South St. Mary's St., San Antonio, TX 78205 Call ~10.44 miles north of 78221
  • Affordable Downtown hotel
  • Hotel has 131 suites
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From$96 total
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Hampton Inn & Suites San Antonio-Downtown/Market Square : 411 South Flores St. 411 South Flores St., San Antonio, TX 78204 Call ~10.46 miles north of 78221
  • Three Star Downtown hotel
  • Free breakfast
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From$144 total
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Inn on the Riverwalk 129 Woodward Place, San Antonio, TX 78204 Call ~10.46 miles north of 78221
  • Midscale Downtown property
  • Complimentary breakfast is offered
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From$142 total
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Courtyard by Marriott San Antonio Downtown/Market Square in San Antonio 600 South Santa Rosa Ave., San Antonio, TX 78204 Call ~10.47 miles north of 78221
  • 3-star Downtown hotel
  • 3 floors in hotel
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From$142 total
Very good 4.0 /5 Review Score Call BookMore Details
Holiday Inn San Antonio - Dwtn - Market Sq, an IHG Hotel in San Antonio 318 West César East Chávez Blvd., San Antonio, TX 78204 Call ~10.47 miles north of 78221
  • Mid-scale property
  • Check in time: 4:00pm
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From$96 total
Average 3.0 /5 Hotel Reviews Call BookMore Details
SpringHill Suites San Antonio Downtown/Riverwalk Area in San Antonio 524 South St. Mary's St., San Antonio, TX 78205 Call ~10.48 miles north of 78221
  • Mid-scale Convention Center property
  • 116 rooms in property
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From$96 total
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Holiday Inn Downtown Market Square - San Antonio 318 West Durango Blvd., San Antonio, TX 78204 Call ~10.50 miles north of 78221
  • Midscale Downtown property
  • Hotel has 7 meeting rooms
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From$88 total
Average 3.5 /5 Guest Reviews Call BookMore Details
Holiday Inn San Antonio - Dwtn - Market Sq, an IHG Hotel : 318 West Cesar East Chavez Blvd. 318 West Cesar East Chavez Blvd., San Antonio, TX 78204 Call ~10.51 miles north of 78221
  • Affordable Downtown hotel
  • Gym is available on property
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From$67 total
Very good 4.0 /5 Guest Reviews Call BookMore Details
Club Wyndham La Cascada : 226 Dwyer Ave. 226 Dwyer Ave., San Antonio, TX 78204 Call ~10.52 miles north of 78221
  • High end Downtown hotel
  • Hotel has 10 floors
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From$102 total
Very good 4.0 /5 Recent Reviews Call BookMore Details
Fairmount Hotel The Unbound Collection by Hyatt 401 South Alamo St., San Antonio, TX 78205 Call ~10.53 miles north of 78221
  • Four star Downtown hotel
  • Hotel has 2 meeting rooms
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From$226 total
Average 3.0 /5 Recent Reviews Call BookMore Details
The Kimpton Santo Riverwalk : 431 South Alamo St. 431 South Alamo St., San Antonio, TX 78205 Call ~10.54 miles north of 78221
  • 4-star Downtown hotel
  • Hotel has 10 floors
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From$214 total
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Doubletree by Hilton San Antonio Downtown - San Antonio 502 West Cesar East Chavez Blvd., San Antonio, TX 78207 Call ~10.55 miles north of 78221
  • Midscale Downtown property
  • Hotel has 6 floors
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From$80 total
Average 3.0 /5 Hotel Reviews Call BookMore Details
Doubletree by Hilton San Antonio Downtown 502 West César East Chávez Blvd., San Antonio, TX 78207 Call ~10.55 miles north of 78221
  • 3-star Downtown hotel
  • Check-in: 4PM
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From$90 total
Average 3.0 /5 Reviews Call BookMore Details
O´Brien Historic Hotel 116 Navarrro St., San Antonio, TX 78205 Call ~10.58 miles north of 78221
  • 3 star Downtown hotel
  • Check-in: 3:00PM
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From$92 total
Very good 4.0 /5 Review Score Call BookMore Details
Stay Express Inn & Suites 100 Valley Hi Dr., San Antonio, TX 78227 Call ~10.61 miles northwest of 78221
  • Inexpensive Suburban hotel
  • Check-in: 1:00 PM
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From$44 total
Poor 2.0 /5 Guest Reviews Call BookMore Details
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