Hotels in 78221 - San Antonio TX

Only hotels in 78221 zip code are listed below. Search for cheap and discount hotel rates in San Antonio, TX for your upcoming leisure or conference / group travel. We list the best 78221 hotels and motels so you can review the San Antonio hotel list below to find the perfect lodging. Hotels in Bexar county and area code 210 are also listed.

78221 Hotels & Accommodations

Holiday Inn Express & Suites San Antonio South 410 in San Antonio
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
11400 SE Loop 410 Acc Rd., San Antonio, TX 78221 +1-888-389-4121
  • Mid-scale Suburban hotel
  • Hotel has a green policy Learn more
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From$80
Average 3.0 /5 Read Reviews Call BookMore Details
Best Western Plus Palo Alto Inn & Suites : 12507 SW Loop 410
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
12507 SW Loop 410, San Antonio, TX 78224 +1-888-675-2083 ~4.14 miles northwest of 78221
  • 3 star hotel
  • Comp. Breakfast
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From$59
Very good 4.0 /5 Review Score Call BookMore Details
Days Inn by Wyndham San Antonio at Palo Alto : 9403 Poteet Jourdanton Freeway
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
9403 Poteet Jourdanton Freeway, San Antonio, TX 78224 +1-800-716-8490 ~4.59 miles northwest of 78221
  • Economical Downtown hotel
  • Free breakfast available
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From$60
Average 3.0 /5 Recent Reviews Call BookMore Details
Woodspring Suites San Antonio South
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
7958 Interstate 35 Access Rd., San Antonio, TX 78224 +1-800-805-5223 ~5.58 miles north of 78221
  • 2-star Highway property
  • Hotel has 4 floors
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From$43
Average 3.0 /5 Latest Reviews Call BookMore Details
Baymont by Wyndham San Antonio South Park - San Antonio
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
7202 South Pan Am Expressway, San Antonio, TX 78224 +1-888-965-1860 ~5.95 miles north of 78221
  • Affordable Highway property
  • 2 floors in hotel
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From$80
Poor 2.0 /5 Guest Reviews Call BookMore Details
Motel 6 San Antonio, TX - South : 7950 South Panam Expy
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
7950 South Panam Expy, San Antonio, TX 78224 +1-888-788-5576 ~6.30 miles north of 78221
  • Two star property
  • 3 floors in hotel
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From$60
Poor 2.5 /5 Guest Reviews Call BookMore Details
Embassy Suites by Hilton San Antonio Brooks Hotel & Spa
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
7610 South New Braunfels, San Antonio, TX 78235 +1-888-897-9207 ~6.86 miles northeast of 78221
  • Four-star Downtown hotel
  • Fitness center on property
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From$125
Average 3.0 /5 Recent Reviews Call BookMore Details
Best Western Plus Elmendorf Hotel / San Antonio Hotel in Elmendorf
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
20015 Eagle Ford Way, Elmendorf, TX 78112 +1-888-311-4278 ~6.94 miles east of 78221
  • Mid-scale Highway hotel
  • Fitness / Gym is on-site
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From$80
Very good 4.0 /5 Read Reviews Call BookMore Details
Holiday Inn Express & Suites San Antonio Brooks Cb : 8222 City Base Landing
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
8222 City Base Landing, San Antonio, TX 78235 +1-888-469-4795 ~7.26 miles northeast of 78221
  • Mid-scale Suburban hotel
  • Gym / Fitness Center Available
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From$52
Average 3.0 /5 Reviews Call BookMore Details
Hampton Inn & Suites San Antonio City Base Landing
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
8202 City Base Landing, San Antonio, TX 78235 +1-888-734-9421 ~7.38 miles northeast of 78221
  • Mid-scale Suburban hotel
  • Comp. Breakfast
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From$68
Very good 4.0 /5 Read Reviews Call BookMore Details
La Quinta Inn by Wyndham San Antonio Brooks City Base
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
3180 Goliad Rd., San Antonio, TX 78223 +1-888-841-5292 ~7.54 miles northeast of 78221
  • Cheap Suburban hotel
  • Check in time: 3:00 pm
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From$62
Average 3.0 /5 Read Reviews Call BookMore Details
Econo Lodge San Antonio South in San Antonio
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
606 Division Ave., San Antonio, TX 78214 +1-888-455-5160 ~7.58 miles north of 78221
  • 2 star property
  • Free complimentary breakfast
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From$60
Poor 2.0 /5 Review Score Call BookMore Details
Fairfield Inn & Suites San Antonio Brooks City Base
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
3234 Goliad Rd., San Antonio, TX 78223 +1-888-965-8297 ~7.60 miles northeast of 78221
  • Mid-scale Suburban hotel
  • Free complimentary breakfast
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From$61
Very good 4.0 /5 Latest Reviews Call BookMore Details
Motel 6 San Antonio, TX - Downtown - Alamo Dome - San Antonio
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
748 Hot Wells Blvd., San Antonio, TX 78223 +1-888-906-6358 ~7.74 miles northeast of 78221
  • Cheap Downtown property
  • Hotel has 3 floors
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From$30
Poor 2.5 /5 Read Reviews Call BookMore Details
Super 8 by Wyndham San Antonio/Alamodome Area in San Antonio
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
723 Hot Wells, San Antonio, TX 78223 +1-888-749-6785 ~7.77 miles northeast of 78221
  • Economy Downtown hotel
  • Fitness center on property
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From$60
Very good 4.0 /5 Latest Reviews Call BookMore Details
Quality Suites San Antonio Brooks City Base in San Antonio
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
3602 SE Military Dr., San Antonio, TX 78223 +1-888-878-9982 ~7.88 miles northeast of 78221
  • Midscale Suburban hotel
  • 65 rooms in hotel
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From$49
Average 3.0 /5 Recent Reviews Call BookMore Details
Econo Lodge Inn & Suites : 120 Rustleaf Dr.
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
120 Rustleaf Dr., San Antonio, TX 78242 +1-888-389-4485 ~8.75 miles northwest of 78221
  • 2 star property
  • Check in: 11:00 AM
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From$60
Average 3.0 /5 Read Reviews Call BookMore Details
Econo Lodge Inn & Suites Near Lackland AFB
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
Rustleaf & SW Military Dr., San Antonio, TX 78242 +1-888-389-4121 ~8.77 miles northwest of 78221
  • Low priced property
  • 2 floors in property
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From$60
Average 3.0 /5 Hotel Reviews Call BookMore Details
Stay Nixon in San Antonio
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
423 Blue Star, San Antonio, TX 78204 +1-888-675-2083 ~9.44 miles north of 78221
  • Four-star Downtown property
  • Check-in time: 3:00 pm
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From$99
Average 3.0 /5 Read Reviews Call BookMore Details
Sonder Southtown Suites - San Antonio
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
111 Probandt St., San Antonio, TX 78204 +1-800-716-8490 ~9.56 miles north of 78221
  • Four star Downtown property
  • 15 suites in property
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From$75
Average 3.0 /5 Recent Reviews Call BookMore Details
The Inn at Market Square : 1500 I 35 South Exit 154b Laredo St.
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
1500 I 35 South Exit 154b Laredo St., San Antonio, TX 78204 +1-800-805-5223 ~9.73 miles north of 78221
  • Economy Downtown property
  • 90 rooms in property
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From$35
Poor 2.0 /5 Recent Reviews Call BookMore Details
Days Inn & Suites by Wyndham Braunig Lake in Elmendorf
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
13800 Ih 37 South, Elmendorf, TX 78112 +1-888-965-1860 ~9.88 miles east of 78221
  • Economy Lake property
  • 4 suites in hotel
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From$59
Very good 4.0 /5 Latest Reviews Call BookMore Details
Econo Lodge Inn & Suites Downtown San Antonio Riverwalk Area
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
1122 South Laredo St., San Antonio, TX 78204 +1-888-788-5576 ~10.04 miles north of 78221
  • Two star Downtown property
  • 4 suites in hotel
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From$30
Terrible 1.5 /5 Reviews Call BookMore Details
Super 8 by Wyndham San Antonio/Riverwalk Area
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
302 Roland Ave., San Antonio, TX 78210 +1-888-897-9207 ~10.06 miles north of 78221
  • Low priced Downtown property
  • 55 rooms in property
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From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
Candlewood Suites San Antonio Downtown An Ihg Hotel : 1024 South Laredo St.
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
1024 South Laredo St., San Antonio, TX 78204 +1-888-311-4278 ~10.07 miles north of 78221
  • Low priced Downtown property
  • Hotel has 4 floors
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From$90
Average 3.0 /5 Hotel Reviews Call BookMore Details
Quality Inn Downtown - near Market Square - San Antonio
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
1025 South Frio St., San Antonio, TX 78207 +1-888-469-4795 ~10.10 miles north of 78221
  • Cheap Downtown hotel
  • 31 suites in property
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From$60
Very good 4.0 /5 Recent Reviews Call BookMore Details
Best Western Alamo Suites : 1002 South Laredo St.
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
1002 South Laredo St., San Antonio, TX 78204 +1-888-734-9421 ~10.13 miles north of 78221
  • Affordable Downtown hotel
  • Hotel has 3 floors
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From$75
Very good 4.0 /5 Review Score Call BookMore Details
Best Western Plus Roland Inn & Suites
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
333 Roland Ave., San Antonio, TX 78210 +1-888-841-5292 ~10.18 miles north of 78221
  • Affordable property
  • Hotel has 4 floors
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From$59
Very good 4.0 /5 Guest Reviews Call BookMore Details
River Inn Motel
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
909 South Frio St., San Antonio, TX 78207 +1-888-455-5160 ~10.19 miles north of 78221
  • Inexpensive Downtown hotel
  • Has environment-friendly policy See more
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From$60
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Holiday Inn Express & Suites San Antonio Dtwn Market Area
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
102 El Paso St., San Antonio, TX 78204 +1-888-965-8297 ~10.25 miles north of 78221
  • Two-star Downtown hotel
  • Check-in time: 3:00 PM
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From$65
Very good 4.0 /5 Recent Reviews Call BookMore Details
Residence Inn San Antonio Market Square Downtown
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
628 South Santa Rosa Ave., San Antonio, TX 78204 +1-888-906-6358 ~10.38 miles north of 78221
  • Mid-scale Downtown hotel
  • Check-in: 03:00 PM
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From$80
Average 3.0 /5 Read Reviews Call BookMore Details
Sonder La Villita : 633 South St. Mary's St.
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
633 South St. Mary's St., San Antonio, TX 78205 +1-888-749-6785 ~10.39 miles north of 78221
  • Expensive Downtown hotel
  • Gym is available on property
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From$75
Average 3.0 /5 Hotel Reviews Call BookMore Details
Fairfield Inn & Suites San Antonio Downtown / Market Square in San Antonio
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
620 South Santa Rosa Ave., San Antonio, TX 78204 +1-888-878-9982 ~10.40 miles north of 78221
  • 3 star Downtown property
  • Gym is available on property
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From$80
Average 3.0 /5 Guest Reviews Call BookMore Details
Plaza San Antonio Hotel & Spa, Autograph Collection - San Antonio
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
555 South Alamo St., San Antonio, TX 78205 +1-888-389-4485 ~10.42 miles north of 78221
  • High end Downtown property
  • 23 meeting rooms in property
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From$121
Very good 4.0 /5 Hotel Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham San Antonio Downtown - San Antonio
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
100 West Cesar Chavez Blvd., San Antonio, TX 78204 +1-888-389-4121 ~10.43 miles north of 78221
  • 3-star Downtown hotel
  • Check in: 3:00PM
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From$89
Very good 4.0 /5 Reviews Call BookMore Details
Hyatt Place San Antonio Riverwalk in San Antonio
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
601 South St. Mary's St., San Antonio, TX 78205 +1-888-675-2083 ~10.44 miles north of 78221
  • Mid-scale Downtown property
  • Hotel has a green policy See more
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From$80
Average 3.0 /5 Guest Reviews Call BookMore Details
Hampton Inn & Suites San Antonio-Downtown/Market Square : 411 South Flores St.
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
411 South Flores St., San Antonio, TX 78204 +1-800-716-8490 ~10.46 miles north of 78221
  • Mid-scale Downtown property
  • Check in: 3:00PM
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From$120
Average 3.0 /5 Hotel Reviews Call BookMore Details
Inn on the Riverwalk in San Antonio
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
129 Woodward Place, San Antonio, TX 78204 +1-800-805-5223 ~10.46 miles north of 78221
  • Three Star Downtown property
  • 13 suites in property
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From$119
Very good 4.0 /5 Latest Reviews Call BookMore Details
Courtyard by Marriott San Antonio Downtown/Market Square
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
600 South Santa Rosa Ave., San Antonio, TX 78204 +1-888-965-1860 ~10.47 miles north of 78221
  • Three Star Downtown hotel
  • 2 meeting rooms in property
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From$119
Very good 4.0 /5 Recent Reviews Call BookMore Details
Holiday Inn San Antonio - Dwtn - Market Sq, an IHG Hotel
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
318 West César East Chávez Blvd., San Antonio, TX 78204 +1-888-788-5576 ~10.47 miles north of 78221
  • 3-star property
  • Check-in: 4:00pm
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From$80
Average 3.0 /5 Latest Reviews Call BookMore Details
SpringHill Suites San Antonio Downtown/Riverwalk Area : 524 South St. Mary's St.
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
524 South St. Mary's St., San Antonio, TX 78205 +1-888-897-9207 ~10.48 miles north of 78221
  • Mid-scale Convention Center hotel
  • Check in time: 3:30pm
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From$80
Average 3.0 /5 Reviews Call BookMore Details
Holiday Inn Downtown Market Square in San Antonio
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
318 West Durango Blvd., San Antonio, TX 78204 +1-888-311-4278 ~10.50 miles north of 78221
  • 3 star Downtown hotel
  • Check-in time: 4:00pm
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From$74
Average 3.5 /5 Review Score Call BookMore Details
Holiday Inn San Antonio - Dwtn - Market Sq, an IHG Hotel - San Antonio
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
318 West Cesar East Chavez Blvd., San Antonio, TX 78204 +1-888-469-4795 ~10.51 miles north of 78221
  • Affordable Downtown hotel
  • 310 rooms in hotel
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From$56
Very good 4.0 /5 Recent Reviews Call BookMore Details
Club Wyndham La Cascada
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
226 Dwyer Ave., San Antonio, TX 78204 +1-888-734-9421 ~10.52 miles north of 78221
  • High-end Downtown property
  • Hotel has 10 floors
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From$85
Very good 4.0 /5 Review Score Call BookMore Details
Fairmount Hotel The Unbound Collection by Hyatt in San Antonio
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
401 South Alamo St., San Antonio, TX 78205 +1-888-841-5292 ~10.53 miles north of 78221
  • 4-star Downtown property
  • 37 sleeping rooms in hotel
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From$189
Average 3.0 /5 Guest Reviews Call BookMore Details
Doubletree by Hilton San Antonio Downtown : 502 West Cesar East Chavez Blvd.
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
502 West Cesar East Chavez Blvd., San Antonio, TX 78207 +1-888-455-5160 ~10.55 miles north of 78221
  • Mid-scale Downtown hotel
  • 11 meeting rooms in hotel
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From$67
Average 3.0 /5 Hotel Reviews Call BookMore Details
Doubletree by Hilton San Antonio Downtown
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
502 West César East Chávez Blvd., San Antonio, TX 78207 +1-888-965-8297 ~10.55 miles north of 78221
  • 3-star Downtown hotel
  • Check in time: 4PM
More Photos
From$75
Average 3.0 /5 Reviews Call BookMore Details
O´Brien Historic Hotel in San Antonio
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
116 Navarrro St., San Antonio, TX 78205 +1-888-906-6358 ~10.58 miles north of 78221
  • Three Star Downtown property
  • Free comp. breakfast
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From$77
Very good 4.0 /5 Recent Reviews Call BookMore Details
Stay Express Inn & Suites
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
100 Valley Hi Dr., San Antonio, TX 78227 +1-888-749-6785 ~10.61 miles northwest of 78221
  • Economical Suburban property
  • Check in: 1:00 PM
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From$37
Poor 2.0 /5 Hotel Reviews Call BookMore Details
Staybridge Suites San Antonio Downtown Conv Ctr by IHG in San Antonio
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
123 Hoefgen Ave., San Antonio, TX 78205 +1-888-878-9982 ~10.65 miles north of 78221
  • Mid-scale Downtown hotel
  • Fitness / Gym is on-site
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From$105
Very good 4.0 /5 Recent Reviews Call BookMore Details
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