Hotels in 78221 - San Antonio TX

Only hotels in 78221 zip code are listed below. Search for cheap and discount hotel rates in San Antonio, TX for your upcoming leisure or conference / group travel. We list the best 78221 hotels and motels so you can review the San Antonio hotel list below to find the perfect lodging. Hotels in Bexar county and area code 210 are also listed.

78221 Hotels & Accommodations

Holiday Inn Express & Suites San Antonio South 410 - San Antonio 11400 SE Loop 410 Acc Rd., San Antonio, TX 78221 Call
  • Mid-scale Suburban hotel
  • 80 sleeping rooms in hotel
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From$80
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Best Western Plus Palo Alto Inn & Suites 12507 SW Loop 410, San Antonio, TX 78224 Call ~4.14 miles northwest of 78221
  • 3 star property
  • Check in time: 03:00
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From$59
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Days Inn by Wyndham San Antonio at Palo Alto in San Antonio 9403 Poteet Jourdanton Freeway, San Antonio, TX 78224 Call ~4.59 miles northwest of 78221
  • Low-priced Downtown hotel
  • Check in: 11:00 AM
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From$60
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Woodspring Suites San Antonio South in San Antonio 7958 Interstate 35 Access Rd., San Antonio, TX 78224 Call ~5.58 miles north of 78221
  • Inexpensive Highway hotel
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From$43
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Baymont by Wyndham San Antonio South Park in San Antonio 7202 South Pan Am Expressway, San Antonio, TX 78224 Call ~5.95 miles north of 78221
  • Three Star Highway hotel
  • 122 sleeping rooms in hotel
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From$80
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Motel 6 San Antonio, TX - South - San Antonio 7950 South Panam Expy, San Antonio, TX 78224 Call ~6.30 miles north of 78221
  • Cheap hotel
  • Check-in: 13:00
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From$60
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Embassy Suites by Hilton San Antonio Brooks Hotel & Spa in San Antonio 7610 South New Braunfels, San Antonio, TX 78235 Call ~6.86 miles northeast of 78221
  • 4-star Downtown property
  • 156 rooms in property
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From$125
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Best Western Plus Elmendorf Hotel / San Antonio Hotel - Elmendorf 20015 Eagle Ford Way, Elmendorf, TX 78112 Call ~6.94 miles east of 78221
  • Midscale Highway property
  • 9 suites in property
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From$80
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Holiday Inn Express & Suites San Antonio Brooks Cb in San Antonio 8222 City Base Landing, San Antonio, TX 78235 Call ~7.26 miles northeast of 78221
  • Three Star Suburban hotel
  • 4 floors in hotel
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From$52
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Hampton Inn & Suites San Antonio City Base Landing 8202 City Base Landing, San Antonio, TX 78235 Call ~7.38 miles northeast of 78221
  • 3-star Suburban property
  • Gym is available on property
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From$68
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La Quinta Inn by Wyndham San Antonio Brooks City Base 3180 Goliad Rd., San Antonio, TX 78223 Call ~7.54 miles northeast of 78221
  • Economy Suburban property
  • Comp. Breakfast
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From$62
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Econo Lodge San Antonio South - San Antonio 606 Division Ave., San Antonio, TX 78214 Call ~7.58 miles north of 78221
  • 2-star property
  • Free breakfast
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From$60
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Fairfield Inn & Suites San Antonio Brooks City Base 3234 Goliad Rd., San Antonio, TX 78223 Call ~7.60 miles northeast of 78221
  • Mid-scale Suburban hotel
  • Free complimentary breakfast
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From$61
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Motel 6 San Antonio, TX - Downtown - Alamo Dome - San Antonio 748 Hot Wells Blvd., San Antonio, TX 78223 Call ~7.74 miles northeast of 78221
  • Economical Downtown hotel
  • 74 rooms in property
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From$30
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Super 8 by Wyndham San Antonio/Alamodome Area in San Antonio 723 Hot Wells, San Antonio, TX 78223 Call ~7.77 miles northeast of 78221
  • Economical Downtown property
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From$60
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Quality Suites San Antonio Brooks City Base 3602 SE Military Dr., San Antonio, TX 78223 Call ~7.88 miles northeast of 78221
  • Mid-scale Suburban property
  • Complimentary breakfast is offered
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From$49
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Econo Lodge Inn & Suites - San Antonio 120 Rustleaf Dr., San Antonio, TX 78242 Call ~8.75 miles northwest of 78221
  • 2-star hotel
  • Check in: 11:00 AM
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From$60
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Econo Lodge Inn & Suites Near Lackland AFB : Rustleaf & SW Military Dr. Rustleaf & SW Military Dr., San Antonio, TX 78242 Call ~8.77 miles northwest of 78221
  • Low priced hotel
  • Hotel has 32 rooms
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From$60
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Stay Nixon 423 Blue Star, San Antonio, TX 78204 Call ~9.44 miles north of 78221
  • 4 star Downtown hotel
  • Hotel has 4 floors
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From$99
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Sonder Southtown Suites 111 Probandt St., San Antonio, TX 78204 Call ~9.56 miles north of 78221
  • High-end Downtown property
  • Check in time: 4:00pm
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From$75
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The Inn at Market Square : 1500 I 35 South Exit 154b Laredo St. 1500 I 35 South Exit 154b Laredo St., San Antonio, TX 78204 Call ~9.73 miles north of 78221
  • Economy Downtown property
  • Comp. Breakfast
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From$35
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Days Inn & Suites by Wyndham Braunig Lake - Elmendorf 13800 Ih 37 South, Elmendorf, TX 78112 Call ~9.88 miles east of 78221
  • Low priced Lake property
  • 4 suites in hotel
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From$59
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Econo Lodge Inn & Suites Downtown San Antonio Riverwalk Area 1122 South Laredo St., San Antonio, TX 78204 Call ~10.04 miles north of 78221
  • Inexpensive Downtown property
  • 4 suites in hotel
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From$30
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Super 8 by Wyndham San Antonio/Riverwalk Area : 302 Roland Ave. 302 Roland Ave., San Antonio, TX 78210 Call ~10.06 miles north of 78221
  • Cheap Downtown property
  • 55 rooms in hotel
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From$60
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Candlewood Suites San Antonio Downtown An Ihg Hotel : 1024 South Laredo St. 1024 South Laredo St., San Antonio, TX 78204 Call ~10.07 miles north of 78221
  • Two-star Downtown hotel
  • Hotel has 4 floors
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From$90
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Days Inn by Wyndham San Antonio Downtown 1025 South Frio St., San Antonio, TX 78207 Call ~10.10 miles north of 78221
  • Low-priced Downtown property
  • 85 rooms in property
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From$60
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Best Western Alamo Suites in San Antonio 1002 South Laredo St., San Antonio, TX 78204 Call ~10.13 miles north of 78221
  • Affordable Downtown hotel
  • Check in: 03:00
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From$75
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Best Western Plus Roland Inn & Suites - San Antonio 333 Roland Ave., San Antonio, TX 78210 Call ~10.18 miles north of 78221
  • Midscale hotel
  • 69 rooms in hotel
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From$59
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River Inn Motel 909 South Frio St., San Antonio, TX 78207 Call ~10.19 miles north of 78221
  • Cheap Downtown hotel
  • Hotel has a green policy See policy
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From$60
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Holiday Inn Express & Suites San Antonio Dtwn Market Area 102 El Paso St., San Antonio, TX 78204 Call ~10.25 miles north of 78221
  • Economy Downtown hotel
  • Fitness center on property
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From$65
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Residence Inn San Antonio Market Square Downtown - San Antonio 628 South Santa Rosa Ave., San Antonio, TX 78204 Call ~10.38 miles north of 78221
  • Midscale Downtown hotel
  • 95 rooms in property
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From$80
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Sonder La Villita in San Antonio 633 South St. Mary's St., San Antonio, TX 78205 Call ~10.39 miles north of 78221
  • Four star Downtown hotel
  • 5 floors in property
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From$75
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Fairfield Inn & Suites San Antonio Downtown / Market Square : 620 South Santa Rosa Ave. 620 South Santa Rosa Ave., San Antonio, TX 78204 Call ~10.40 miles north of 78221
  • Mid-scale Downtown property
  • 4 floors in hotel
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From$80
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La Quinta Inn & Suites by Wyndham San Antonio Downtown : 100 West Cesar Chavez Blvd. 100 West Cesar Chavez Blvd., San Antonio, TX 78204 Call ~10.43 miles north of 78221
  • 3 star Downtown property
  • Check-in: 3:00PM
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From$89
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Plaza Hotel & Spa San Antonio Autograph Collection - San Antonio 555 South Alamo St., San Antonio, TX 78205 Call ~10.43 miles north of 78221
  • Four star Downtown property
  • Fitness center on property
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From$137
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Hyatt Place San Antonio Riverwalk 601 South St. Mary's St., San Antonio, TX 78205 Call ~10.44 miles north of 78221
  • Three Star Downtown property
  • Free comp. breakfast
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From$80
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Hampton Inn & Suites San Antonio-Downtown/Market Square 411 South Flores St., San Antonio, TX 78204 Call ~10.46 miles north of 78221
  • Affordable Downtown hotel
  • Free complimentary breakfast
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From$120
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Inn on the Riverwalk in San Antonio 129 Woodward Place, San Antonio, TX 78204 Call ~10.46 miles north of 78221
  • Three Star Downtown property
  • 13 suites in hotel
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From$119
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Courtyard by Marriott San Antonio Downtown/Market Square in San Antonio 600 South Santa Rosa Ave., San Antonio, TX 78204 Call ~10.47 miles north of 78221
  • Three Star Downtown property
  • 2 meeting rooms in hotel
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From$119
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Holiday Inn San Antonio - Dwtn - Market Sq, an IHG Hotel in San Antonio 318 West César East Chávez Blvd., San Antonio, TX 78204 Call ~10.47 miles north of 78221
  • Three Star property
  • Check in time: 4:00pm
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From$80
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SpringHill Suites San Antonio Downtown/Riverwalk Area in San Antonio 524 South St. Mary's St., San Antonio, TX 78205 Call ~10.48 miles north of 78221
  • 3-star Convention Center hotel
  • 116 rooms in hotel
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From$80
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Holiday Inn Downtown Market Square in San Antonio 318 West Durango Blvd., San Antonio, TX 78204 Call ~10.50 miles north of 78221
  • Midscale Downtown hotel
  • Check in: 4:00pm
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From$74
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Holiday Inn San Antonio - Dwtn - Market Sq, an IHG Hotel : 318 West Cesar East Chavez Blvd. 318 West Cesar East Chavez Blvd., San Antonio, TX 78204 Call ~10.51 miles north of 78221
  • Mid-scale Downtown hotel
  • 2 suites in property
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From$56
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Club Wyndham La Cascada : 226 Dwyer Ave. 226 Dwyer Ave., San Antonio, TX 78204 Call ~10.52 miles north of 78221
  • High-end Downtown hotel
  • 97 rooms in property
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From$85
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Fairmount Hotel The Unbound Collection by Hyatt - San Antonio 401 South Alamo St., San Antonio, TX 78205 Call ~10.53 miles north of 78221
  • 4-star Downtown property
  • Hotel has 2 meeting rooms
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From$189
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The Kimpton Santo Riverwalk 431 South Alamo St., San Antonio, TX 78205 Call ~10.54 miles north of 78221
  • 4-star Downtown property
  • Has environment-friendly policy Learn more
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From$179
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Doubletree by Hilton San Antonio Downtown - San Antonio 502 West Cesar East Chavez Blvd., San Antonio, TX 78207 Call ~10.55 miles north of 78221
  • Affordable Downtown property
  • 11 meeting rooms in property
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From$67
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Doubletree by Hilton San Antonio Downtown - San Antonio 502 West César East Chávez Blvd., San Antonio, TX 78207 Call ~10.55 miles north of 78221
  • Three Star Downtown property
  • Gym is available on property
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From$75
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O´Brien Historic Hotel in San Antonio 116 Navarrro St., San Antonio, TX 78205 Call ~10.58 miles north of 78221
  • Mid-scale Downtown property
  • Hotel has 39 rooms
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From$77
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Stay Express Inn & Suites - San Antonio 100 Valley Hi Dr., San Antonio, TX 78227 Call ~10.61 miles northwest of 78221
  • Two star Suburban property
  • 62 sleeping rooms in hotel
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From$37
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