Hotels in 78221 - San Antonio TX

Only hotels in 78221 zip code are listed below. Search for cheap and discount hotel rates in San Antonio, TX for your upcoming leisure or conference / group travel. We list the best 78221 hotels and motels so you can review the San Antonio hotel list below to find the perfect lodging. Hotels in Bexar county and area code 210 are also listed.

78221 Hotels/Motels & Accommodations

Holiday Inn Express & Suites San Antonio South 410 - San Antonio
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
11400 SE Loop 410 Acc Rd., San Antonio, TX 78221 +1-888-389-4121
  • Affordable Suburban hotel
  • Hotel has 17 suites
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From$80
Average 3.0 /5 Review Score Call BookMore Details
Best Western Plus Palo Alto Inn & Suites
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
12507 SW Loop 410, San Antonio, TX 78224 +1-888-675-2083 ~4.14 miles northwest of 78221
  • Affordable hotel
  • Check in time: 03:00
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From$59
Very good 4.0 /5 Latest Reviews Call BookMore Details
Days Inn by Wyndham San Antonio at Palo Alto
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
9403 Poteet Jourdanton Freeway, San Antonio, TX 78224 +1-800-716-8490 ~4.59 miles northwest of 78221
  • Low priced Downtown property
  • Comp. Breakfast
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From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
Woodspring Suites San Antonio South
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
7958 Interstate 35 Access Rd., San Antonio, TX 78224 +1-800-805-5223 ~5.58 miles north of 78221
  • Economical Highway hotel
  • 4 floors in hotel
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From$43
Average 3.0 /5 Recent Reviews Call BookMore Details
Baymont by Wyndham San Antonio South Park in San Antonio
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
7202 South Pan Am Expressway, San Antonio, TX 78224 +1-888-965-1860 ~5.95 miles north of 78221
  • Three Star Highway property
  • Free complimentary breakfast
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From$80
Poor 2.0 /5 Hotel Reviews Call BookMore Details
Motel 6 San Antonio, TX - South in San Antonio
+1-888-788-5576

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New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
7950 South Panam Expy, San Antonio, TX 78224 +1-888-788-5576 ~6.30 miles north of 78221
  • Low priced property
  • Check in time: 13:00
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From$60
Poor 2.5 /5 Reviews Call BookMore Details
Embassy Suites by Hilton San Antonio Brooks Hotel & Spa : 7610 South New Braunfels
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
7610 South New Braunfels, San Antonio, TX 78235 +1-888-897-9207 ~6.86 miles northeast of 78221
  • High end Downtown property
  • Check in: 4:00pm
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From$125
Average 3.0 /5 Recent Reviews Call BookMore Details
Best Western Plus Elmendorf Hotel / San Antonio Hotel
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
20015 Eagle Ford Way, Elmendorf, TX 78112 +1-888-311-4278 ~6.94 miles east of 78221
  • Affordable Highway hotel
  • Gym is available on property
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From$80
Very good 4.0 /5 Reviews Call BookMore Details
Holiday Inn Express & Suites San Antonio Brooks Cb in San Antonio
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
8222 City Base Landing, San Antonio, TX 78235 +1-888-469-4795 ~7.26 miles northeast of 78221
  • Three Star Suburban property
  • Check-in: 3:00 PM
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From$52
Average 3.0 /5 Read Reviews Call BookMore Details
Hampton Inn & Suites San Antonio City Base Landing : 8202 City Base Landing
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
8202 City Base Landing, San Antonio, TX 78235 +1-888-734-9421 ~7.38 miles northeast of 78221
  • 3-star Suburban hotel
  • 100 sleeping rooms in hotel
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From$68
Very good 4.0 /5 Review Score Call BookMore Details
La Quinta Inn by Wyndham San Antonio Brooks City Base in San Antonio
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
3180 Goliad Rd., San Antonio, TX 78223 +1-888-841-5292 ~7.54 miles northeast of 78221
  • Economy Suburban property
  • Gym / Fitness Center Available
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From$62
Average 3.0 /5 Read Reviews Call BookMore Details
Econo Lodge San Antonio South - San Antonio
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
606 Division Ave., San Antonio, TX 78214 +1-888-455-5160 ~7.58 miles north of 78221
  • Cheap hotel
  • Check in time: 12:00
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From$60
Poor 2.0 /5 Latest Reviews Call BookMore Details
Fairfield Inn & Suites San Antonio Brooks City Base - San Antonio
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
3234 Goliad Rd., San Antonio, TX 78223 +1-888-965-8297 ~7.60 miles northeast of 78221
  • Three Star Suburban hotel
  • Free complimentary breakfast
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From$61
Very good 4.0 /5 Recent Reviews Call BookMore Details
Motel 6 San Antonio, TX - Downtown - Alamo Dome - San Antonio
+1-888-906-6358

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New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
748 Hot Wells Blvd., San Antonio, TX 78223 +1-888-906-6358 ~7.74 miles northeast of 78221
  • Low priced Downtown hotel
  • Check-in time: 400pm
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From$30
Poor 2.5 /5 Guest Reviews Call BookMore Details
Super 8 by Wyndham San Antonio/Alamodome Area in San Antonio
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
723 Hot Wells, San Antonio, TX 78223 +1-888-749-6785 ~7.77 miles northeast of 78221
  • Inexpensive Downtown property
  • Check in: 3:00pm
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From$60
Very good 4.0 /5 Review Score Call BookMore Details
Quality Suites San Antonio Brooks City Base
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
3602 SE Military Dr., San Antonio, TX 78223 +1-888-878-9982 ~7.88 miles northeast of 78221
  • 3-star Suburban hotel
  • Complimentary breakfast is offered
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From$49
Average 3.0 /5 Latest Reviews Call BookMore Details
Econo Lodge Inn & Suites - San Antonio
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
120 Rustleaf Dr., San Antonio, TX 78242 +1-888-389-4485 ~8.75 miles northwest of 78221
  • Inexpensive property
  • Check in: 11:00 AM
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From$60
Average 3.0 /5 Latest Reviews Call BookMore Details
Econo Lodge Inn & Suites Near Lackland AFB - San Antonio
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
Rustleaf & SW Military Dr., San Antonio, TX 78242 +1-888-389-4121 ~8.77 miles northwest of 78221
  • 2-star hotel
  • Check in time: 3:00 PM
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From$60
Average 3.0 /5 Latest Reviews Call BookMore Details
Stay Nixon - San Antonio
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
423 Blue Star, San Antonio, TX 78204 +1-888-675-2083 ~9.44 miles north of 78221
  • 4-star Downtown property
  • Access to gym on-site
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From$99
Average 3.0 /5 Review Score Call BookMore Details
Sonder Southtown Suites : 111 Probandt St.
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
111 Probandt St., San Antonio, TX 78204 +1-800-716-8490 ~9.56 miles north of 78221
  • 4-star Downtown hotel
  • Check in time: 4:00pm
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From$75
Average 3.0 /5 Guest Reviews Call BookMore Details
The Inn at Market Square - San Antonio
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
1500 I 35 South Exit 154b Laredo St., San Antonio, TX 78204 +1-800-805-5223 ~9.73 miles north of 78221
  • Cheap Downtown property
  • 90 rooms in property
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From$35
Poor 2.0 /5 Review Score Call BookMore Details
Days Inn & Suites by Wyndham Braunig Lake - Elmendorf
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
13800 Ih 37 South, Elmendorf, TX 78112 +1-888-965-1860 ~9.88 miles east of 78221
  • Cheap Lake hotel
  • Check in time: 3:00 pm
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From$59
Very good 4.0 /5 Latest Reviews Call BookMore Details
Econo Lodge Inn & Suites Downtown San Antonio Riverwalk Area
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
1122 South Laredo St., San Antonio, TX 78204 +1-888-788-5576 ~10.04 miles north of 78221
  • Low Cost Downtown property
  • Complimentary breakfast is offered
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From$30
Terrible 1.5 /5 Read Reviews Call BookMore Details
Super 8 by Wyndham San Antonio/Riverwalk Area - San Antonio
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
302 Roland Ave., San Antonio, TX 78210 +1-888-897-9207 ~10.06 miles north of 78221
  • 2 star Downtown property
  • 55 sleeping rooms in hotel
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From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
Candlewood Suites San Antonio Downtown An Ihg Hotel
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
1024 South Laredo St., San Antonio, TX 78204 +1-888-311-4278 ~10.07 miles north of 78221
  • Low priced Downtown hotel
  • Check in time: 3:00 pm
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From$90
Average 3.0 /5 Reviews Call BookMore Details
Days Inn by Wyndham San Antonio Downtown
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
1025 South Frio St., San Antonio, TX 78207 +1-888-469-4795 ~10.10 miles north of 78221
  • Low Cost Downtown property
  • Hotel has 3 floors
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From$60
Very good 4.0 /5 Reviews Call BookMore Details
Best Western Alamo Suites - San Antonio
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
1002 South Laredo St., San Antonio, TX 78204 +1-888-734-9421 ~10.13 miles north of 78221
  • Midscale Downtown property
  • Complimentary breakfast is offered
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From$75
Very good 4.0 /5 Read Reviews Call BookMore Details
Best Western Plus Roland Inn & Suites
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
333 Roland Ave., San Antonio, TX 78210 +1-888-841-5292 ~10.18 miles north of 78221
  • Midscale property
  • 14 suites in property
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From$59
Very good 4.0 /5 Hotel Reviews Call BookMore Details
River Inn Motel in San Antonio
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
909 South Frio St., San Antonio, TX 78207 +1-888-455-5160 ~10.19 miles north of 78221
  • Low priced Downtown property
  • Check in time: 3:00PM
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From$60
Very good 4.0 /5 Read Reviews Call BookMore Details
Holiday Inn Express & Suites San Antonio Dtwn Market Area
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
102 El Paso St., San Antonio, TX 78204 +1-888-965-8297 ~10.25 miles north of 78221
  • Cheap Downtown hotel
  • Free breakfast available
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From$65
Very good 4.0 /5 Reviews Call BookMore Details
Residence Inn San Antonio Market Square Downtown
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
628 South Santa Rosa Ave., San Antonio, TX 78204 +1-888-906-6358 ~10.38 miles north of 78221
  • 3-star Downtown property
  • 95 rooms in hotel
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From$80
Average 3.0 /5 Hotel Reviews Call BookMore Details
Sonder La Villita in San Antonio
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
633 South St. Mary's St., San Antonio, TX 78205 +1-888-749-6785 ~10.39 miles north of 78221
  • 4-star Downtown property
  • Check-in: 4:00 PM
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From$75
Average 3.0 /5 Reviews Call BookMore Details
Fairfield Inn & Suites San Antonio Downtown / Market Square in San Antonio
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
620 South Santa Rosa Ave., San Antonio, TX 78204 +1-888-878-9982 ~10.40 miles north of 78221
  • Affordable Downtown property
  • Free breakfast available
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From$80
Average 3.0 /5 Read Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham San Antonio Downtown
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
100 West Cesar Chavez Blvd., San Antonio, TX 78204 +1-888-389-4485 ~10.43 miles north of 78221
  • Midscale Downtown property
  • 151 sleeping rooms in hotel
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From$89
Very good 4.0 /5 Guest Reviews Call BookMore Details
Plaza Hotel & Spa San Antonio Autograph Collection
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
555 South Alamo St., San Antonio, TX 78205 +1-888-389-4121 ~10.43 miles north of 78221
  • 4-star Downtown hotel
  • 7 floors in hotel
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From$137
Average 3.0 /5 Review Score Call BookMore Details
Hyatt Place San Antonio Riverwalk
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
601 South St. Mary's St., San Antonio, TX 78205 +1-888-675-2083 ~10.44 miles north of 78221
  • Three Star Downtown property
  • Hotel has 131 rooms
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From$80
Average 3.0 /5 Review Score Call BookMore Details
Hampton Inn & Suites San Antonio-Downtown/Market Square - San Antonio
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
411 South Flores St., San Antonio, TX 78204 +1-800-716-8490 ~10.46 miles north of 78221
  • 3-star Downtown property
  • Check-in: 3:00PM
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From$120
Average 3.0 /5 Recent Reviews Call BookMore Details
Inn on the Riverwalk
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
129 Woodward Place, San Antonio, TX 78204 +1-800-805-5223 ~10.46 miles north of 78221
  • 3-star Downtown property
  • Free breakfast available
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From$119
Very good 4.0 /5 Reviews Call BookMore Details
Courtyard by Marriott San Antonio Downtown/Market Square in San Antonio
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
600 South Santa Rosa Ave., San Antonio, TX 78204 +1-888-965-1860 ~10.47 miles north of 78221
  • Affordable Downtown property
  • 3 floors in property
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From$119
Very good 4.0 /5 Latest Reviews Call BookMore Details
Holiday Inn San Antonio - Dwtn - Market Sq, an IHG Hotel in San Antonio
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
318 West César East Chávez Blvd., San Antonio, TX 78204 +1-888-788-5576 ~10.47 miles north of 78221
  • Affordable property
  • Access to gym on-site
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From$80
Average 3.0 /5 Hotel Reviews Call BookMore Details
SpringHill Suites San Antonio Downtown/Riverwalk Area
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
524 South St. Mary's St., San Antonio, TX 78205 +1-888-897-9207 ~10.48 miles north of 78221
  • Affordable Convention Center hotel
  • Fitness + Health Center
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From$80
Average 3.0 /5 Hotel Reviews Call BookMore Details
Holiday Inn Downtown Market Square - San Antonio
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
318 West Durango Blvd., San Antonio, TX 78204 +1-888-311-4278 ~10.50 miles north of 78221
  • Affordable Downtown hotel
  • 7 meeting rooms in hotel
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From$74
Average 3.5 /5 Latest Reviews Call BookMore Details
Holiday Inn San Antonio - Dwtn - Market Sq, an IHG Hotel in San Antonio
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
318 West Cesar East Chavez Blvd., San Antonio, TX 78204 +1-888-469-4795 ~10.51 miles north of 78221
  • Midscale Downtown property
  • Access to gym on-site
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From$56
Very good 4.0 /5 Guest Reviews Call BookMore Details
Club Wyndham La Cascada in San Antonio
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
226 Dwyer Ave., San Antonio, TX 78204 +1-888-734-9421 ~10.52 miles north of 78221
  • Four star Downtown hotel
  • Check in: 4
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From$85
Very good 4.0 /5 Review Score Call BookMore Details
Fairmount Hotel The Unbound Collection by Hyatt in San Antonio
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
401 South Alamo St., San Antonio, TX 78205 +1-888-841-5292 ~10.53 miles north of 78221
  • High-end Downtown hotel
  • 37 rooms in hotel
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From$189
Average 3.0 /5 Hotel Reviews Call BookMore Details
The Kimpton Santo Riverwalk
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
431 South Alamo St., San Antonio, TX 78205 +1-888-455-5160 ~10.54 miles north of 78221
  • Expensive Downtown property
  • 10 floors in hotel
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From$179
Average 3.0 /5 Recent Reviews Call BookMore Details
Doubletree by Hilton San Antonio Downtown
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
502 West Cesar East Chavez Blvd., San Antonio, TX 78207 +1-888-965-8297 ~10.55 miles north of 78221
  • Midscale Downtown property
  • Hotel has 6 floors
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From$67
Average 3.0 /5 Recent Reviews Call BookMore Details
Doubletree by Hilton San Antonio Downtown : 502 West César East Chávez Blvd.
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
502 West César East Chávez Blvd., San Antonio, TX 78207 +1-888-906-6358 ~10.55 miles north of 78221
  • Three Star Downtown hotel
  • 9 meeting rooms in property
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From$75
Average 3.0 /5 Latest Reviews Call BookMore Details
O´Brien Historic Hotel in San Antonio
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
116 Navarrro St., San Antonio, TX 78205 +1-888-749-6785 ~10.58 miles north of 78221
  • Affordable Downtown property
  • Free breakfast available
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From$77
Very good 4.0 /5 Read Reviews Call BookMore Details
Stay Express Inn & Suites in San Antonio
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
100 Valley Hi Dr., San Antonio, TX 78227 +1-888-878-9982 ~10.61 miles northwest of 78221
  • Two-star Suburban hotel
  • Comp. Breakfast
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From$37
Poor 2.0 /5 Latest Reviews Call BookMore Details
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