Hotels in 78221 - San Antonio TX

Only hotels in 78221 zip code are listed below. Search for cheap and discount hotel rates in San Antonio, TX for your upcoming leisure or conference / group travel. We list the best 78221 hotels and motels so you can review the San Antonio hotel list below to find the perfect lodging. Hotels in Bexar county and area code 210 are also listed.

78221 Hotels/Motels & Accommodations

Holiday Inn Express & Suites San Antonio South 410 in San Antonio 11400 SE Loop 410 Acc Rd., San Antonio, TX 78221 Call
  • Midscale Suburban hotel
  • Check in: 04:00pm
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From$80
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Best Western Plus Palo Alto Inn & Suites in San Antonio 12507 SW Loop 410, San Antonio, TX 78224 Call ~4.14 miles northwest of 78221
  • Midscale property
  • Check in: 03:00
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From$58
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Days Inn by Wyndham San Antonio at Palo Alto 9403 Poteet Jourdanton Freeway, San Antonio, TX 78224 Call ~4.59 miles northwest of 78221
  • 2 star Downtown property
  • Check in time: 11:00 AM
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From$60
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Woodspring Suites San Antonio South - San Antonio 7958 Interstate 35 Access Rd., San Antonio, TX 78224 Call ~5.58 miles north of 78221
  • Low priced Highway hotel
  • Check-in time: 3:00 PM
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From$43
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Baymont by Wyndham San Antonio South Park - San Antonio 7202 South Pan Am Expressway, San Antonio, TX 78224 Call ~5.95 miles north of 78221
  • Three Star Highway property
  • Free breakfast
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From$80
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Motel 6 San Antonio, TX - South 7950 South Panam Expy, San Antonio, TX 78224 Call ~6.30 miles north of 78221
  • Cheap property
  • Hotel has 3 floors
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From$60
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Embassy Suites by Hilton San Antonio Brooks Hotel & Spa in San Antonio 7610 South New Braunfels, San Antonio, TX 78235 Call ~6.86 miles northeast of 78221
  • High end Downtown hotel
  • Hotel has 156 suites
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From$125
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Best Western Plus Elmendorf Hotel / San Antonio Hotel 20015 Eagle Ford Way, Elmendorf, TX 78112 Call ~6.94 miles east of 78221
  • 3 star Highway property
  • Hotel has an eco-friendly policy Learn more
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From$80
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Holiday Inn Express & Suites San Antonio Brooks Cb - San Antonio 8222 City Base Landing, San Antonio, TX 78235 Call ~7.26 miles northeast of 78221
  • Three Star Suburban property
  • Gym is available on property
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From$52
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Hampton Inn & Suites San Antonio City Base Landing 8202 City Base Landing, San Antonio, TX 78235 Call ~7.38 miles northeast of 78221
  • Midscale Suburban hotel
  • Fitness center on property
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From$68
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La Quinta Inn by Wyndham San Antonio Brooks City Base - San Antonio 3180 Goliad Rd., San Antonio, TX 78223 Call ~7.54 miles northeast of 78221
  • Economy Suburban property
  • Hotel has 115 rooms
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From$62
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Econo Lodge San Antonio South : 606 Division Ave. 606 Division Ave., San Antonio, TX 78214 Call ~7.58 miles north of 78221
  • Cheap hotel
  • Check in time: 12:00
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From$60
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Fairfield Inn & Suites San Antonio Brooks City Base - San Antonio 3234 Goliad Rd., San Antonio, TX 78223 Call ~7.60 miles northeast of 78221
  • Midscale Suburban hotel
  • Hotel has 17 suites
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From$61
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Motel 6 San Antonio, TX - Downtown - Alamo Dome 748 Hot Wells Blvd., San Antonio, TX 78223 Call ~7.74 miles northeast of 78221
  • Two-star Downtown property
  • Hotel has 3 floors
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From$30
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Super 8 by Wyndham San Antonio/Alamodome Area in San Antonio 723 Hot Wells, San Antonio, TX 78223 Call ~7.77 miles northeast of 78221
  • Cheap Downtown hotel
  • Check-in time: 3:00pm
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From$60
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Quality Suites San Antonio Brooks City Base in San Antonio 3602 SE Military Dr., San Antonio, TX 78223 Call ~7.88 miles northeast of 78221
  • Midscale Suburban property
  • Hotel has an eco-friendly policy See policy
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From$49
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Econo Lodge Inn & Suites : 120 Rustleaf Dr. 120 Rustleaf Dr., San Antonio, TX 78242 Call ~8.75 miles northwest of 78221
  • Low Cost hotel
  • Check in: 11:00 AM
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From$60
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Econo Lodge Inn & Suites Near Lackland AFB - San Antonio Rustleaf & SW Military Dr., San Antonio, TX 78242 Call ~8.77 miles northwest of 78221
  • 2 star property
  • Hotel has 32 rooms
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From$60
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Stay Nixon 423 Blue Star, San Antonio, TX 78204 Call ~9.44 miles north of 78221
  • 4-star Downtown hotel
  • Access to gym on-site
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From$99
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Sonder Southtown Suites in San Antonio 111 Probandt St., San Antonio, TX 78204 Call ~9.56 miles north of 78221
  • High end Downtown property
  • Gym / Fitness Center Available
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From$75
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The Inn at Market Square - San Antonio 1500 I 35 South Exit 154b Laredo St., San Antonio, TX 78204 Call ~9.73 miles north of 78221
  • Two star Downtown property
  • 90 rooms in property
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From$35
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Days Inn & Suites by Wyndham Braunig Lake - Elmendorf 13800 Ih 37 South, Elmendorf, TX 78112 Call ~9.88 miles east of 78221
  • Low Cost Lake hotel
  • Hotel has 2 floors
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From$59
Very good 4.0 /5 Guest Reviews Call BookMore Details
Econo Lodge Inn & Suites Downtown San Antonio Riverwalk Area 1122 South Laredo St., San Antonio, TX 78204 Call ~10.04 miles north of 78221
  • Two star Downtown property
  • 4 suites in property
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From$30
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Super 8 by Wyndham San Antonio/Riverwalk Area 302 Roland Ave., San Antonio, TX 78210 Call ~10.06 miles north of 78221
  • Low priced Downtown property
  • 28 suites in hotel
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From$60
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Candlewood Suites San Antonio Downtown An Ihg Hotel - San Antonio 1024 South Laredo St., San Antonio, TX 78204 Call ~10.07 miles north of 78221
  • Cheap Downtown property
  • Check-in: 3:00 pm
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From$90
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Days Inn by Wyndham San Antonio Downtown 1025 South Frio St., San Antonio, TX 78207 Call ~10.10 miles north of 78221
  • Economical Downtown hotel
  • 85 rooms in hotel
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From$60
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Best Western Alamo Suites - San Antonio 1002 South Laredo St., San Antonio, TX 78204 Call ~10.13 miles north of 78221
  • Midscale Downtown property
  • 72 suites in hotel
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From$75
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Best Western Plus Roland Inn & Suites in San Antonio 333 Roland Ave., San Antonio, TX 78210 Call ~10.18 miles north of 78221
  • Three Star hotel
  • Check in time: 03:00
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From$57
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River Inn Motel 909 South Frio St., San Antonio, TX 78207 Call ~10.19 miles north of 78221
  • 2-star Downtown property
  • Check in time: 3:00PM
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From$60
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Holiday Inn Express & Suites San Antonio Dtwn Market Area - San Antonio 102 El Paso St., San Antonio, TX 78204 Call ~10.25 miles north of 78221
  • Economical Downtown property
  • Free breakfast
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From$65
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Residence Inn San Antonio Market Square Downtown - San Antonio 628 South Santa Rosa Ave., San Antonio, TX 78204 Call ~10.38 miles north of 78221
  • 3-star Downtown hotel
  • Hotel has 95 rooms
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From$80
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Sonder La Villita 633 South St. Mary's St., San Antonio, TX 78205 Call ~10.39 miles north of 78221
  • Four star Downtown property
  • 5 floors in hotel
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From$75
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Fairfield Inn & Suites San Antonio Downtown / Market Square 620 South Santa Rosa Ave., San Antonio, TX 78204 Call ~10.40 miles north of 78221
  • 3 star Downtown property
  • Hotel has 110 rooms
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From$80
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La Quinta Inn & Suites by Wyndham San Antonio Downtown 100 West Cesar Chavez Blvd., San Antonio, TX 78204 Call ~10.43 miles north of 78221
  • 3 star Downtown property
  • Check-in: 3:00PM
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From$89
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Plaza Hotel & Spa San Antonio Autograph Collection in San Antonio 555 South Alamo St., San Antonio, TX 78205 Call ~10.43 miles north of 78221
  • High-end Downtown property
  • Check in: 4:00 PM
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From$137
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Hyatt Place San Antonio Riverwalk : 601 South St. Mary's St. 601 South St. Mary's St., San Antonio, TX 78205 Call ~10.44 miles north of 78221
  • Midscale Downtown property
  • Hotel has an eco-friendly policy Read more
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From$80
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Hampton Inn & Suites San Antonio-Downtown/Market Square 411 South Flores St., San Antonio, TX 78204 Call ~10.46 miles north of 78221
  • Affordable Downtown hotel
  • 108 rooms in property
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From$120
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Inn on the Riverwalk in San Antonio 129 Woodward Place, San Antonio, TX 78204 Call ~10.46 miles north of 78221
  • Affordable Downtown property
  • 3 floors in hotel
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From$119
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Courtyard by Marriott San Antonio Downtown/Market Square 600 South Santa Rosa Ave., San Antonio, TX 78204 Call ~10.47 miles north of 78221
  • 3 star Downtown property
  • 3 floors in hotel
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From$119
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Holiday Inn San Antonio - Dwtn - Market Sq, an IHG Hotel : 318 West César East Chávez Blvd. 318 West César East Chávez Blvd., San Antonio, TX 78204 Call ~10.47 miles north of 78221
  • Affordable hotel
  • Check in: 4:00pm
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From$80
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SpringHill Suites San Antonio Downtown/Riverwalk Area 524 South St. Mary's St., San Antonio, TX 78205 Call ~10.48 miles north of 78221
  • 3-star Convention Center property
  • Free breakfast available
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From$80
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Holiday Inn Downtown Market Square : 318 West Durango Blvd. 318 West Durango Blvd., San Antonio, TX 78204 Call ~10.50 miles north of 78221
  • 3-star Downtown property
  • Check-in time: 4:00pm
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From$74
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Holiday Inn San Antonio - Dwtn - Market Sq, an IHG Hotel in San Antonio 318 West Cesar East Chavez Blvd., San Antonio, TX 78204 Call ~10.51 miles north of 78221
  • Midscale Downtown property
  • 4 floors in hotel
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From$56
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Club Wyndham La Cascada - San Antonio 226 Dwyer Ave., San Antonio, TX 78204 Call ~10.52 miles north of 78221
  • Four star Downtown hotel
  • 10 floors in property
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From$85
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Fairmount Hotel The Unbound Collection by Hyatt in San Antonio 401 South Alamo St., San Antonio, TX 78205 Call ~10.53 miles north of 78221
  • Expensive Downtown hotel
  • 2 conference rooms in property
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From$189
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The Kimpton Santo Riverwalk - San Antonio 431 South Alamo St., San Antonio, TX 78205 Call ~10.54 miles north of 78221
  • Four-star Downtown hotel
  • Hotel has 10 floors
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From$179
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Doubletree by Hilton San Antonio Downtown 502 West Cesar East Chavez Blvd., San Antonio, TX 78207 Call ~10.55 miles north of 78221
  • Affordable Downtown property
  • 6 floors in hotel
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From$67
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Doubletree by Hilton San Antonio Downtown in San Antonio 502 West César East Chávez Blvd., San Antonio, TX 78207 Call ~10.55 miles north of 78221
  • Midscale Downtown property
  • 250 rooms in property
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From$75
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O´Brien Historic Hotel 116 Navarrro St., San Antonio, TX 78205 Call ~10.58 miles north of 78221
  • Three Star Downtown property
  • Has environment-friendly policy See more
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From$77
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Stay Express Inn & Suites : 100 Valley Hi Dr. 100 Valley Hi Dr., San Antonio, TX 78227 Call ~10.61 miles northwest of 78221
  • 2 star Suburban property
  • 2 floors in property
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From$37
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