Hotels in 78221 - San Antonio TX

Only hotels in 78221 zip code are listed below. Search for cheap and discount hotel rates in San Antonio, TX for your upcoming leisure or conference / group travel. We list the best 78221 hotels and motels so you can review the San Antonio hotel list below to find the perfect lodging. Hotels in Bexar county and area code 210 are also listed.

78221 Hotels & Accommodations

Holiday Inn Express & Suites San Antonio South 410 - San Antonio 11400 SE Loop 410 Acc Rd., San Antonio, TX 78221 Call
  • Mid-scale Suburban property
  • Free complimentary breakfast
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From$80
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Best Western Plus Palo Alto Inn & Suites - San Antonio 12507 SW Loop 410, San Antonio, TX 78224 Call ~4.14 miles northwest of 78221
  • 3-star property
  • 32 suites in hotel
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From$59
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Days Inn by Wyndham San Antonio at Palo Alto in San Antonio 9403 Poteet Jourdanton Freeway, San Antonio, TX 78224 Call ~4.59 miles northwest of 78221
  • Two star Downtown hotel
  • Free complimentary breakfast
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From$60
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Woodspring Suites San Antonio South in San Antonio 7958 Interstate 35 Access Rd., San Antonio, TX 78224 Call ~5.58 miles north of 78221
  • 2 star Highway hotel
  • 121 sleeping rooms in hotel
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From$43
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Baymont by Wyndham San Antonio South Park - San Antonio 7202 South Pan Am Expressway, San Antonio, TX 78224 Call ~5.95 miles north of 78221
  • Mid-scale Highway hotel
  • 2 floors in property
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From$80
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Motel 6 San Antonio, TX - South 7950 South Panam Expy, San Antonio, TX 78224 Call ~6.30 miles north of 78221
  • Inexpensive property
  • 3 floors in hotel
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From$60
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Embassy Suites by Hilton San Antonio Brooks Hotel & Spa : 7610 South New Braunfels 7610 South New Braunfels, San Antonio, TX 78235 Call ~6.86 miles northeast of 78221
  • 4-star Downtown hotel
  • Check-in: 4:00pm
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From$125
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Best Western Plus Elmendorf Hotel / San Antonio Hotel : 20015 Eagle Ford Way 20015 Eagle Ford Way, Elmendorf, TX 78112 Call ~6.94 miles east of 78221
  • Mid-scale Highway property
  • Free comp. breakfast
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From$80
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Holiday Inn Express & Suites San Antonio Brooks Cb 8222 City Base Landing, San Antonio, TX 78235 Call ~7.26 miles northeast of 78221
  • 3 star Suburban property
  • 95 sleeping rooms in hotel
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From$52
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Hampton Inn & Suites San Antonio City Base Landing 8202 City Base Landing, San Antonio, TX 78235 Call ~7.38 miles northeast of 78221
  • Midscale Suburban hotel
  • 32 suites in property
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From$68
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La Quinta Inn by Wyndham San Antonio Brooks City Base 3180 Goliad Rd., San Antonio, TX 78223 Call ~7.54 miles northeast of 78221
  • Low Cost Suburban property
  • 2 floors in hotel
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From$62
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Econo Lodge San Antonio South : 606 Division Ave. 606 Division Ave., San Antonio, TX 78214 Call ~7.58 miles north of 78221
  • Cheap hotel
  • Free comp. breakfast
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From$60
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Fairfield Inn & Suites San Antonio Brooks City Base 3234 Goliad Rd., San Antonio, TX 78223 Call ~7.60 miles northeast of 78221
  • Midscale Suburban hotel
  • 17 suites in hotel
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From$61
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Motel 6 San Antonio, TX - Downtown - Alamo Dome in San Antonio 748 Hot Wells Blvd., San Antonio, TX 78223 Call ~7.74 miles northeast of 78221
  • Cheap Downtown property
  • Hotel has 74 rooms
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From$30
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Super 8 by Wyndham San Antonio/Alamodome Area : 723 Hot Wells 723 Hot Wells, San Antonio, TX 78223 Call ~7.77 miles northeast of 78221
  • Two-star Downtown property
  • Fitness / Gym is on-site
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From$60
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Quality Suites San Antonio Brooks City Base - San Antonio 3602 SE Military Dr., San Antonio, TX 78223 Call ~7.88 miles northeast of 78221
  • 3 star Suburban hotel
  • 3 floors in property
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From$49
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Econo Lodge Inn & Suites - San Antonio 120 Rustleaf Dr., San Antonio, TX 78242 Call ~8.75 miles northwest of 78221
  • 2-star hotel
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From$60
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Econo Lodge Inn & Suites Near Lackland AFB Rustleaf & SW Military Dr., San Antonio, TX 78242 Call ~8.77 miles northwest of 78221
  • Cheap property
  • 2 floors in hotel
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From$60
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Stay Nixon 423 Blue Star, San Antonio, TX 78204 Call ~9.44 miles north of 78221
  • Four-star Downtown hotel
  • Check-in: 3:00 pm
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From$99
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Sonder Southtown Suites 111 Probandt St., San Antonio, TX 78204 Call ~9.56 miles north of 78221
  • 4 star Downtown property
  • Hotel has 15 suites
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From$75
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The Inn at Market Square in San Antonio 1500 I 35 South Exit 154b Laredo St., San Antonio, TX 78204 Call ~9.73 miles north of 78221
  • Economy Downtown property
  • Comp. Breakfast
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From$35
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Days Inn & Suites by Wyndham Braunig Lake in Elmendorf 13800 Ih 37 South, Elmendorf, TX 78112 Call ~9.88 miles east of 78221
  • 2 star Lake hotel
  • 4 suites in property
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From$59
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Econo Lodge Inn & Suites Downtown San Antonio Riverwalk Area - San Antonio 1122 South Laredo St., San Antonio, TX 78204 Call ~10.04 miles north of 78221
  • Inexpensive Downtown property
  • 50 rooms in hotel
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From$30
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Super 8 by Wyndham San Antonio/Riverwalk Area : 302 Roland Ave. 302 Roland Ave., San Antonio, TX 78210 Call ~10.06 miles north of 78221
  • 2 star Downtown hotel
  • Check in time: 3:00pm
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From$60
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Candlewood Suites San Antonio Downtown An Ihg Hotel 1024 South Laredo St., San Antonio, TX 78204 Call ~10.07 miles north of 78221
  • Two star Downtown hotel
  • Gym is available on property
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From$90
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Days Inn by Wyndham San Antonio Downtown : 1025 South Frio St. 1025 South Frio St., San Antonio, TX 78207 Call ~10.10 miles north of 78221
  • 2-star Downtown property
  • Hotel has 3 floors
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Best Western Alamo Suites - San Antonio 1002 South Laredo St., San Antonio, TX 78204 Call ~10.13 miles north of 78221
  • Three Star Downtown hotel
  • 3 floors in hotel
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From$75
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Best Western Plus Roland Inn & Suites 333 Roland Ave., San Antonio, TX 78210 Call ~10.18 miles north of 78221
  • Three Star hotel
  • 69 rooms in hotel
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From$59
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River Inn Motel - San Antonio 909 South Frio St., San Antonio, TX 78207 Call ~10.19 miles north of 78221
  • 2-star Downtown hotel
  • 20 rooms in property
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From$60
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Holiday Inn Express & Suites San Antonio Dtwn Market Area : 102 El Paso St. 102 El Paso St., San Antonio, TX 78204 Call ~10.25 miles north of 78221
  • Inexpensive Downtown property
  • Free comp. breakfast
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From$65
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Residence Inn San Antonio Market Square Downtown - San Antonio 628 South Santa Rosa Ave., San Antonio, TX 78204 Call ~10.38 miles north of 78221
  • Midscale Downtown property
  • Hotel has 3 floors
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From$80
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Sonder La Villita - San Antonio 633 South St. Mary's St., San Antonio, TX 78205 Call ~10.39 miles north of 78221
  • 4 star Downtown hotel
  • Check in: 4:00 PM
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From$75
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Fairfield Inn & Suites San Antonio Downtown / Market Square 620 South Santa Rosa Ave., San Antonio, TX 78204 Call ~10.40 miles north of 78221
  • Three Star Downtown property
  • Hotel has a green policy Learn more
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La Quinta Inn & Suites by Wyndham San Antonio Downtown - San Antonio 100 West Cesar Chavez Blvd., San Antonio, TX 78204 Call ~10.43 miles north of 78221
  • 3 star Downtown hotel
  • 4 meeting rooms in property
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From$89
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Plaza Hotel & Spa San Antonio Autograph Collection in San Antonio 555 South Alamo St., San Antonio, TX 78205 Call ~10.43 miles north of 78221
  • Four-star Downtown property
  • Check in time: 4:00 PM
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From$137
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Hyatt Place San Antonio Riverwalk 601 South St. Mary's St., San Antonio, TX 78205 Call ~10.44 miles north of 78221
  • Three Star Downtown hotel
  • Free breakfast
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Hampton Inn & Suites San Antonio-Downtown/Market Square - San Antonio 411 South Flores St., San Antonio, TX 78204 Call ~10.46 miles north of 78221
  • Three Star Downtown property
  • Complimentary breakfast is offered
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From$120
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Inn on the Riverwalk in San Antonio 129 Woodward Place, San Antonio, TX 78204 Call ~10.46 miles north of 78221
  • Midscale Downtown hotel
  • Free breakfast
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From$119
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Courtyard by Marriott San Antonio Downtown/Market Square 600 South Santa Rosa Ave., San Antonio, TX 78204 Call ~10.47 miles north of 78221
  • 3 star Downtown hotel
  • 3 floors in hotel
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From$119
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Holiday Inn San Antonio - Dwtn - Market Sq, an IHG Hotel 318 West César East Chávez Blvd., San Antonio, TX 78204 Call ~10.47 miles north of 78221
  • 3-star hotel
  • Check-in: 4:00pm
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From$80
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SpringHill Suites San Antonio Downtown/Riverwalk Area 524 South St. Mary's St., San Antonio, TX 78205 Call ~10.48 miles north of 78221
  • Affordable Convention Center hotel
  • Gym is available on property
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Holiday Inn Downtown Market Square : 318 West Durango Blvd. 318 West Durango Blvd., San Antonio, TX 78204 Call ~10.50 miles north of 78221
  • 3 star Downtown property
  • Check-in: 4:00pm
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From$74
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Holiday Inn San Antonio - Dwtn - Market Sq, an IHG Hotel 318 West Cesar East Chavez Blvd., San Antonio, TX 78204 Call ~10.51 miles north of 78221
  • Mid-scale Downtown property
  • 2 suites in hotel
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From$56
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Club Wyndham La Cascada 226 Dwyer Ave., San Antonio, TX 78204 Call ~10.52 miles north of 78221
  • Expensive Downtown hotel
  • 97 suites in property
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From$85
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Fairmount Hotel The Unbound Collection by Hyatt - San Antonio 401 South Alamo St., San Antonio, TX 78205 Call ~10.53 miles north of 78221
  • High-end Downtown property
  • Hotel has 14 suites
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From$189
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The Kimpton Santo Riverwalk : 431 South Alamo St. 431 South Alamo St., San Antonio, TX 78205 Call ~10.54 miles north of 78221
  • 4-star Downtown hotel
  • Fitness center on property
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From$179
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Doubletree by Hilton San Antonio Downtown : 502 West Cesar East Chavez Blvd. 502 West Cesar East Chavez Blvd., San Antonio, TX 78207 Call ~10.55 miles north of 78221
  • Midscale Downtown property
  • 22 suites in hotel
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From$67
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Doubletree by Hilton San Antonio Downtown 502 West César East Chávez Blvd., San Antonio, TX 78207 Call ~10.55 miles north of 78221
  • Midscale Downtown property
  • 9 conference rooms in property
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From$75
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O´Brien Historic Hotel - San Antonio 116 Navarrro St., San Antonio, TX 78205 Call ~10.58 miles north of 78221
  • 3 star Downtown hotel
  • Check-in time: 3:00PM
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From$77
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Stay Express Inn & Suites : 100 Valley Hi Dr. 100 Valley Hi Dr., San Antonio, TX 78227 Call ~10.61 miles northwest of 78221
  • Low priced Suburban property
  • 62 sleeping rooms in hotel
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From$37
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