"I would stay in Greektown close to Ford Field"
Detroit is a city that has recently caught a bad rap in the media but if you know where to go, it can be a great experience. I would stay in Greektown close to Ford Field, Comerica Park, the Fox Theatre, and the Greektown Casino. You should be careful at night, don't wonder too far from Greektown but as long as you stay in that area you are safe. There are tons of restaurants ranging from upscale to your hole in the wall pub. Check the schedule for Saint Andrews Hall for a small, unique rock venue or the Detroit Symphony Orchestra if you like classical. I recommend visiting in the summer because there are tons of music, art, and food festivals going on the river front as well as the Woodward Dream Cruise in August where over 1,000,000 classic cars come to the area to cruise Woodward Ave.