Hilton Jacksonville at Mayo Clinic

4745 Transformation Wy, Jacksonville, FL 32224 United States (USA)
View Map Reservations: 1-800-219-2797
4.5 Star Property
30.257715-81.443085
+1-800-219-2797
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Check Current Prices






Standard prices by room type for the next 60 days

Rates shown are nightly rates before taxes and do not necessarily reflect all discounts available. The chart provides the cheapest public rates available by room type.

Room types

Check rates1 King Bed
Non-smoking
Check rates1 King Bed Accessible
Non-smoking
Check rates1 King Bed Accessible Hearing
Non-smoking
Check rates1 King Bed Accessible Hearing 1 King Bed
Non-smoking
Check rates1 King Bed Chair Bed
Non-smoking
Check rates1 King Bed Corner Junior Suite Water View
Non-smoking
Check rates1 King Bed Corner Junior Suite Water View 620 Sq Ft Floor To Ceiling Windows 55in TV Free Standing T
Non-smoking
Check rates1 King Bed Deluxe Water View with Sofa
Non-smoking
Check rates1 King Bed Deluxe Water View with Sofa 444 Sq Ft Free WiFi Sofa 55 Inch TV MiniFridge, Microwave Dou
Non-smoking
Check rates1 King Bed Hearing Accessible
Non-smoking
Check rates1 King Bed Hearing Accessible Outdoor View
Non-smoking
Check rates1 King Bed Hearing Accessible Visual Firealarm Door Phone Alert 325 Sq Ft 55 Inch HDTV Refrigerator,
Non-smoking
Check rates1 King Bed Junior Suite Open Floor Plan
Non-smoking
Check rates1 King Bed Junior Suite Open Floor Plan 486 Sq Ft Free WiFi Sofa 55 Inch TV MiniFridge, Microwave Do
Non-smoking
Check rates1 King Bed Water View
Non-smoking
Check rates1 King Bed Water View 325 Sq Ft Free WiFi Luxury Linens 55 Inch TV MiniFridge, Microwave, Coffeemake
Non-smoking
Check rates1 King Bed Water View Accessible
Non-smoking
Check rates1 King Bed Water View Hearing Accessible
Non-smoking
Check rates1 King Bed Water View Hearing Accessible Vis Doorbell Alrt and Phone Alrt 55 Inch HDTV, Free WiFi Lu
Non-smoking
Check rates1 King Bed Water View Roll in Shower
Non-smoking
Check rates1 King Bed with Chaise
Non-smoking
Check rates1 King Bed with Chaise 325 Sq Ft Free WiFi Luxury Linens 55 Inch TV MiniFridge, Microwave, Coffeemak
Non-smoking
Check rates1 King Deluxe Water View Accessible Roll in Shower
Non-smoking
Check rates1 King Deluxe Water View Accessible Roll in Shower 444 Sq Ft Free WiFi Luxury Linens 55 in HDTV Sofa
Non-smoking
Check rates1 King Junior Suite Accessible with Roll in Shower 486 Sq Ft Free WiFi Luxury Linens Sofa 55 Inch HD
Non-smoking
Check rates1 King Junior Suite Mobility Accessible with Roll in Shower
Non-smoking
Check rates1 King Junior Suite Mobility Hearing Acesss Roll in Shower
Non-smoking
Check rates1 King Junior Suite Mobility Hearing Acesss Roll in Shower Visual Firealarm Door Phone Alert 486 Sq
Non-smoking
Check rates1 King Water View Accessible Roll in Shower
Non-smoking
Check rates1 King Water View Accessible Roll in Shower 325 Sq Ft Free WiFi Luxury Linens 55 in HDTV Refrigerato
Non-smoking
Check rates2 Queen Accessible with Bathtub 340 Sq Ft WiFi Avail Luxury Linens Free WiFi 55 in HDTV Refrigerator
Non-smoking
Check rates2 Queen Beds
Non-smoking
Check rates2 Queen Beds 340 Sq Ft Free WiFi Luxury Linens 55 Inch TV MiniFridge, Microwave, Coffeemaker Safe
Non-smoking
Check rates2 Queen Beds Accessible
Non-smoking
Check rates2 Queen Beds Accessible Bathtub
Non-smoking
Check rates2 Queen Beds Accessible Bathtub 2 Queenbed
Non-smoking
Check rates2 Queen Beds Accessible Bathtub View
Non-smoking
Check rates2 Queen Beds Accessible Hearing
Non-smoking
Check rates2 Queen Beds Accessible Hearing 2 Queenbed
Non-smoking
Check rates2 Queen Beds Accessible Water View Hearing
Non-smoking
Check rates2 Queen Beds Hearing Accessible
Non-smoking
Check rates2 Queen Beds Water View
Non-smoking
Check rates2 Queen Beds Water View 340 Sq Ft Free WiFi Luxury Linens 55 Inch TV MiniFridge, Microwave, Coffeema
Non-smoking
Check rates2 Queen Beds Water View Accessible
Non-smoking
Check rates2 Queen Hearing Accessible Room
Non-smoking
Check rates2 Queen Hearing Accessible Room Visual Firealarm Door Phone Alert 340 Sq Ft 55 in HDTV, Free WiFi, R
Non-smoking
Check rates2 Queen Mobility Accessible with Bathtub
Non-smoking
Check rates2 Queen Water View Hearing Accessible Room
Non-smoking
Check rates2 Queen Water View Hearing Accessible Room Visual Firealarm Door Phone Alert 340 Sq Ft Free WiFi, Re
Non-smoking
Check rates2 Queen Water Vw Accessible Bathtub
Non-smoking
Check rates2 Queen Water Vw Accessible Bathtub 340 Sq Ft Free WiFi Luxury Linens 55 Inch TV Refrigerator, Micro
Non-smoking
Check rates2x Points 1 King Bed Corner Junior Suite Water View 620 Sq Ft Floor To Ceiling Windows 55in TV Free
Non-smoking
Check rates2x Points 1 King Bed Deluxe Water View with Sofa 444 Sq Ft Free WiFi Sofa 55 Inch TV MiniFridge, Mic
Non-smoking
Check rates2x Points 1 King Bed Hearing Accessible Visual Firealarm Door Phone Alert 325 Sq Ft 55 Inch HDTV Ref
Non-smoking
Check rates2x Points 1 King Bed Junior Suite Open Floor Plan 486 Sq Ft Free WiFi Sofa 55 Inch TV MiniFridge, Mi
Non-smoking
Check rates2x Points 1 King Bed Water View 325 Sq Ft Free WiFi Luxury Linens 55 Inch TV MiniFridge, Microwave,
Non-smoking
Check rates2x Points 1 King Bed Water View Hearing Accessible Vis Doorbell Alrt and Phone Alrt 55 Inch HDTV, Fr
Non-smoking
Check rates2x Points 1 King Bed with Chaise 325 Sq Ft Free WiFi Luxury Linens 55 Inch TV MiniFridge, Microwave,
Non-smoking
Check rates2x Points 1 King Deluxe Water View Accessible Roll in Shower 444 Sq Ft Free WiFi Luxury Linens 55 in
Non-smoking
Check rates2x Points 1 King Junior Suite Accessible with Roll in Shower 486 Sq Ft Free WiFi Luxury Linens Sofa
Non-smoking
Check rates2x Points 1 King Junior Suite Mobility Hearing Acesss Roll in Shower Visual Firealarm Door Phone Ale
Non-smoking
Check rates2x Points 1 King Water View Accessible Roll in Shower 325 Sq Ft Free WiFi Luxury Linens 55 in HDTV R
Non-smoking
Check rates2x Points 2 Queen Accessible with Bathtub 340 Sq Ft WiFi Avail Luxury Linens Free WiFi 55 in HDTV Re
Non-smoking
Check rates2x Points 2 Queen Beds 340 Sq Ft Free WiFi Luxury Linens 55 Inch TV MiniFridge, Microwave, Coffeemak
Non-smoking
Check rates2x Points 2 Queen Beds Water View 340 Sq Ft Free WiFi Luxury Linens 55 Inch TV MiniFridge, Microwave
Non-smoking
Check rates2x Points 2 Queen Hearing Accessible Room Visual Firealarm Door Phone Alert 340 Sq Ft 55 in HDTV, Fr
Non-smoking
Check rates2x Points 2 Queen Water View Hearing Accessible Room Visual Firealarm Door Phone Alert 340 Sq Ft Fre
Non-smoking
Check rates2x Points 2 Queen Water Vw Accessible Bathtub 340 Sq Ft Free WiFi Luxury Linens 55 Inch TV Refrigera
Non-smoking
Check rates2x Points Corner King Junior Suite Accessible Roll in Shower 486 Sq Ft Free WiFi Luxury Linens 55 In
Non-smoking
Check ratesBreakfast Buffet Included 1 King Bed Corner Junior Suite Water View 620 Sq Ft Floor To Ceiling Windo
Non-smoking
Check ratesBreakfast Buffet Included 1 King Bed Deluxe Water View with Sofa 444 Sq Ft Free WiFi Sofa 55 Inch TV
Non-smoking
Check ratesBreakfast Buffet Included 1 King Bed Hearing Accessible Visual Firealarm Door Phone Alert 325 Sq Ft
Non-smoking
Check ratesBreakfast Buffet Included 1 King Bed Junior Suite Open Floor Plan 486 Sq Ft Free WiFi Sofa 55 Inch T
Non-smoking
Check ratesBreakfast Buffet Included 1 King Bed Water View 325 Sq Ft Free WiFi Luxury Linens 55 Inch TV MiniFri
Non-smoking
Check ratesBreakfast Buffet Included 1 King Bed Water View Hearing Accessible Vis Doorbell Alrt and Phone Alrt
Non-smoking
Check ratesBreakfast Buffet Included 1 King Bed with Chaise 325 Sq Ft Free WiFi Luxury Linens 55 Inch TV MiniFr
Non-smoking
Check ratesBreakfast Buffet Included 1 King Deluxe Water View Accessible Roll in Shower 444 Sq Ft Free WiFi Lux
Non-smoking
Check ratesBreakfast Buffet Included 1 King Junior Suite Accessible with Roll in Shower 486 Sq Ft Free WiFi Lux
Non-smoking
Check ratesBreakfast Buffet Included 1 King Junior Suite Mobility Hearing Acesss Roll in Shower Visual Firealar
Non-smoking
Check ratesBreakfast Buffet Included 1 King Water View Accessible Roll in Shower 325 Sq Ft Free WiFi Luxury Lin
Non-smoking
Check ratesBreakfast Buffet Included 2 Queen Accessible with Bathtub 340 Sq Ft WiFi Avail Luxury Linens Free Wi
Non-smoking
Check ratesBreakfast Buffet Included 2 Queen Beds 340 Sq Ft Free WiFi Luxury Linens 55 Inch TV MiniFridge, Micr
Non-smoking
Check ratesBreakfast Buffet Included 2 Queen Beds Water View 340 Sq Ft Free WiFi Luxury Linens 55 Inch TV MiniF
Non-smoking
Check ratesBreakfast Buffet Included 2 Queen Hearing Accessible Room Visual Firealarm Door Phone Alert 340 Sq F
Non-smoking
Check ratesBreakfast Buffet Included 2 Queen Water View Hearing Accessible Room Visual Firealarm Door Phone Ale
Non-smoking
Check ratesBreakfast Buffet Included 2 Queen Water Vw Accessible Bathtub 340 Sq Ft Free WiFi Luxury Linens 55 I
Non-smoking
Check ratesBreakfast Buffet Included Corner King Junior Suite Accessible Roll in Shower 486 Sq Ft Free WiFi Lux
Non-smoking
Check ratesCorner Junior King Suite with Roll in Shower Accessible
Non-smoking
Check ratesCorner Junior King Suite with Water View
Non-smoking
Check ratesCorner King Junior Suite Accessible Roll in Shower
Non-smoking
Check ratesCorner King Junior Suite Accessible Roll in Shower 486 Sq Ft Free WiFi Luxury Linens 55 Inch HDTV So
Non-smoking
Check ratesDeluxe King Bed Water View Accessible
Non-smoking
Check ratesDeluxe King Bed Water View Sofa
Non-smoking
Check ratesDeluxe King Room with Roll in Shower and Water View Accessible
Non-smoking
Check ratesDeluxe King Room with Sofa and Water View
Non-smoking
Check ratesDeluxe Room 1 King Bed Accessible Roll in Shower
Non-smoking
Check ratesDeluxe Room 1 King Bed Water View
Non-smoking
Check ratesHilton Honors Discount Honors Discount 1 King Bed with Chaise 325 Sq Ft Free WiFi Luxury Linens 55 I
Non-smoking
Check ratesHilton Honors Discount Honors Restricted Cxl 1 King Bed with Chaise 325 Sq Ft Free WiFi Luxury Linen
Non-smoking
Check ratesJunior King Suite Open Floor Plan
Non-smoking
Check ratesJunior King Suite with Roll in Shower Accessible
Non-smoking
Check ratesJunior King Suite with Roll in Shower Mobility Hearing Accessible
Non-smoking
Check ratesJunior Suite 1 King Bed
Non-smoking
Check ratesJunior Suite 1 King Bed Accessible Roll in Shower
Non-smoking
Check ratesJunior Suite 1 King Bed Corner
Non-smoking
Check ratesJunior Suite King Bed Accessible
Non-smoking
Check ratesKing Room Hearing Accessible
Non-smoking
Check ratesKing Room with Chaise
Non-smoking
Check ratesKing Room with Roll in Shower and Water View Mobility Accessible
Non-smoking
Check ratesKing Room with Water View
Non-smoking
Check ratesKing Room with Water View Hearing Accessible
Non-smoking
Check ratesOpen Plan Junior Suite King Bed
Non-smoking
Check ratesQueen Room with 2 Queen Beds Hearing Accessible
Non-smoking
Check ratesQueen Room with 2 Queen Beds Water View Hearing Accessible
Non-smoking
Check ratesQueen Room with 2 Queen Beds and Accessible Tub Accessible
Non-smoking
Check ratesQueen Room with 2 Queen Beds and Bath Tub Water View Accessible
Non-smoking
Check ratesQueen Room with 2 Queen Beds and Water View
Non-smoking
Check ratesStandard Queen Queen
Non-smoking
Check ratesSuite 1 King Bed Accessible Mobility and Hearing Roll in Shower
Non-smoking
Check ratesSuite 1 King Bed Accessible Mobility and Hearing Roll in Shower 1 King Bed
Non-smoking

Local attractions

Mayo Clinic 1 mile University of North Florida 4 miles Jacksonville Beaches 5 miles St. Johns Town Center 6 miles TPC Sawgrass/ 10 miles EverBank Stadium (Jaquars) 15 miles

Verified reviews of Hilton Jacksonville at Mayo Clinic

Below are the verified reviews from guests that we have booked in recently:
"Comfortable"
Overall score5.0/ 5
Very warm reception, comfortable accommodations.
(Group coordinator, booked 2 room(s)), from US flag
25-Mar-2026 Verified review, stayed from Tue Mar 24 to Wed Mar 25 2026 at a $277.69 average nightly rate.
"Great facility great service"
Overall score5.0/ 5
We will be back again.
(Individual traveller, booked 1 room), from US flag
15-Feb-2026 Verified review, stayed from Thu Feb 12 to Fri Feb 13 2026 at a $204.99 average nightly rate.
"Good hotel"
Overall score5.0/ 5
Everything fantastic.
(Individual traveller, booked 1 room), from US flag
06-Feb-2026 Verified review, stayed from Sun Feb 01 to Thu Feb 05 2026 at a $701.92 average nightly rate.
"Thank you for such a wonderful place to stay"
Overall score5.0/ 5
The nicest hotel we have ever stayed in. Filled with elegance and the people were full of care and always so helpful. Thank you for your kindness and we will be back.❤️.
(Group coordinator, booked 2 room(s)), from US flag
21-Jan-2026 Verified review, stayed from Tue Jan 20 to Thu Jan 22 2026 at a $291.99 average nightly rate.
4.0 out of 5. Based on 6 guest reviews

Property description

**Opening October 2025!!!** Located on the Mayo Clinic Jacksonville Campus and less than a mile from Mayo Clinic Hospital, our hotel offers easy access to top medical facilities. We're six miles from Jacksonville Beaches and eight miles from St. Johns Town Center. Relax in our heated outdoor pool or host events in our 16,000 sq ft of indoor space and 5,000 sq ft of outdoor patio area.

Details / Other expenses

Check-in: 4:00pm
Check-out: 11:00am
Year of last renovation: 2025
Floors: 8
Rooms: 252
Corridors: All rooms have interior hallways
Non-smoking rooms: 252
Rooms with disabled access: 22
Rooms with one bed: 105
Rooms with two beds: 147
Suites: 21
Room windows: Windows do open
Cleaning frequency: Daily
Meeting rooms: 1 View spaces
Meeting space: 1951.0 sq. metres
Event space: Holds 850 people
Lounge/Bar hours: 10:00am-10:00pm
Pool Info:
Outdoor pool open from 8am-10pm
Policies / Expenses
Nightly parking: 0
Typical group deposit: 25%
Total taxes: 13.50%
Total misc. fees: €0.00 EUR
(mandatory resort fees/taxes)

Breakfast information

Coastal Kitchen offers a delightful dining experience that caters to both the discerning traveler and the local gourmet. The restaurant boasts a contemporary yet cozy ambiance, with modern decor that seamlessly blends comfort and sophistication. Guests can start their day with a hearty breakfast buffet featuring a variety of fresh fruits, pastries, and made-to-order omelets. For lunch and dinner, the menu showcases a diverse selection of dishes, from succulent steaks and fresh seafood to vibrant salads and artisanal pizzas. Each dish is crafted with the finest ingredients, ensuring a burst of flavor in every bite. Coastal Kitchen also features an extensive wine list and a selection of signature cocktails, perfect for unwinding after a long day. Whether you're enjoying a casual meal with family, a business lunch, or a romantic dinner, the attentive staff and inviting atmosphere make every dining experience memorable.

Pet friendly?

Service animals complying with ADA Title lll regulations are allowed.

Sorry but pets are not allowed.

Parking information

Complimentary on-site parking.

Internet/Wi-Fi

Complimentary Wifi for Hilton Honors members. Free to join!

About Hilton Hotels and Resorts

  • Bed & Breakfast Packages for two at select locations
  • Have serenity beds made by Serta and Peter Thomas Roth hair & skincare bath amenities
  • Pre-arrival planning services
  • Pet Friendly Program

The Hilton Hotels and Resorts highlights above are subject to change without notice.

Meeting rooms and event rooms at Hilton Jacksonville at Mayo Clinic

Below are the meeting, conference and event spaces at Hilton Jacksonville at Mayo Clinic.

Feel free to use the Hilton Jacksonville at Mayo Clinic meeting space capacities chart below to help with your event planning. HotelPlanner specialises in Jacksonville event planning for hotel rooms and meeting space for corporate events, weddings, parties, conventions, as well as negotiated rates and trade shows.

Meeting room name L x W x H
(Feet)
Size
(sq ft)
Event
5'/6
Event space layout
Crescent
Crescent tables layout
Classroom
Classroom meeting layout
Hollow
Square
Hollow square table layout
U-shape
U-shape meeting layout
Boardroom
Boardroom meeting space
Convention
8'/10'
Convention booth layout
Theatre
Theatre layout
Reception
Reception desk for meetings
Regist.
desk
Registration desk for meetings
NorthStar Ballroom 100 x 100 x 25 10063--/--------------/--------
Close this

NorthStar Ballroom

Room type:
Ballroom
Total size:
934.9 Sq. km
Dimensions:
100 x 100 x 25 Ft
Floor level:
Is there natural light?
Yes
Are there obstructions?
No
Are there built in screens?
Yes
Is there a built in stage?
No
Is there built in A/V?
No
Amenities available
  • Coffee/Tea Setup
  • Food/Beverage
  • Projection equip.
  • TV/VCR/DVD
  • WIFI Internet
  • Podium
  • LAN Internet
  • Microphone
  • Teleconferencing
  • White Board
  • Video Conference
  • Flip Chart
  • Air Conditioning
  • Computer Rentals
  • Simultaneous Interpretation
  • Sound System
Full-day space rental fee:
$10000.00 USD
24hr reservation rental fee for the space:
$10000.00 USD
Photo of NorthStar Ballroom

FAQs about Hilton Jacksonville at Mayo Clinic

What time is check in?

Check in time is 4:00pm based on the hotel's local time. Early check in may be available if requested at the front desk on the day of check-in.

What time is check out?

Check out time is 11:00am based on the hotel's local time. Late check out may be available if requested at the front desk during your stay.

How many rooms does Hilton Jacksonville at Mayo Clinic have?

There are 252 rooms in the property.

Is there any meeting space at Hilton Jacksonville at Mayo Clinic?

Yes, they have 1 meeting room that can support various table layouts.

What kind of breakfast is at Hilton Jacksonville at Mayo Clinic?

Coastal Kitchen offers a delightful dining experience that caters to both the discerning traveler and the local gourmet. The restaurant boasts a contemporary yet cozy ambiance, with modern decor that seamlessly blends comfort and sophistication. Guests can start their day with a hearty breakfast buffet featuring a variety of fresh fruits, pastries, and made-to-order omelets. For lunch and dinner, the menu showcases a diverse selection of dishes, from succulent steaks and fresh seafood to vibrant salads and artisanal pizzas. Each dish is crafted with the finest ingredients, ensuring a burst of flavor in every bite. Coastal Kitchen also features an extensive wine list and a selection of signature cocktails, perfect for unwinding after a long day. Whether you're enjoying a casual meal with family, a business lunch, or a romantic dinner, the attentive staff and inviting atmosphere make every dining experience memorable.

What parking is available at Hilton Jacksonville at Mayo Clinic?

Complimentary on-site parking.

How much does internet cost?

Complimentary Wifi for Hilton Honors members. Free to join!

Can I get a AAA rate at Hilton Jacksonville at Mayo Clinic?

Yes, they have stay dates that support AAA hotel discounts. Example room type: AAA Aaa 1 King Bed Corner Junior Suite Water View 620 Sq Ft Floor To Ceiling Windows 55in TV Free St

Can I get a Senior or AARP rate at Hilton Jacksonville at Mayo Clinic?

Sorry, this hotel does not offer senior hotel discounts at this time.

Testimonials:

Testimonials icon
"I didn't know such a service existed until I did a search on Google. This service saved my team so much time and effort! It is wonderful that this service is available." C.N. - Minneapolis, MN

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