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Cayce South Carolina Hotels & Motels

Find hotels & motels in Cayce using the list below. Find discounted hotel accommodations in or close to Cayce, SC for your upcoming individual or group travel. We provide the best Cayce, South Carolina hotel and motel rooms. Browse the Cayce area hotels to find the perfect lodging! Please use the provided map of the Cayce hotels. Need 5+ Rooms? Secure Cayce Group Hotel Discounts

The Cayce center point is about 2 miles south of Edventure Children’s Museum and 2 miles southwest of Columbia Amtrak.

Cayce Hotels, Motels & Accommodations

Country Hearth Inn & Suites Cayce / Columbia
+1-888-389-4121

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New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
3020 Charleston Highway, Cayce, SC 29033
  • 2-star property
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From$60
Average 3.0 /5 Latest Reviews Call BookMore Details
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Knights Inn Columbia Airport/Cayce in Cayce
+1-888-675-2083

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New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
1987 Airport Blvd., Cayce, SC 29033
  • 2-star hotel
  • 117 sleeping rooms in hotel
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From$53
Poor 2.0 /5 Hotel Reviews Call BookMore Details
Econo Lodge Inn & Suites Cayce I-26 Airport
+1-800-716-8490

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New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
1935 Airport Blvd., Cayce, SC 29033
  • Two star Airport property
  • Hotel has 9 suites
More Photos Image of Econo Lodge Inn & Suites Cayce I-26 Airport
From$69
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Masters Inn Columbia Knox Abbott - Cayce
+1-800-805-5223

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New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
613 Knox Abbott Dr., Cayce, NC 29033
  • Affordable property
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From$74
Average 3.0 /5 Guest Reviews Call BookMore Details
Motel 6 West Columbia Sc Airport in West Columbia
+1-888-965-1860

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New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
650 Cherokee Lane, West Columbia, SC 29169 ~1.52 miles west of Cayce
  • Two-star Airport hotel
  • Airport shuttle available
More Photos Photo of Motel 6 West Columbia Sc Airport
From$60
Average 3.0 /5 Recent Reviews Call BookMore Details
Motel 6 West Columbia Sc
+1-888-788-5576

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2200 Airport Blvd., West Columbia, SC 29170 ~1.66 miles west of Cayce
  • Low-priced property
  • Check-in: 3:00 PM
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From$60
Average 3.0 /5 Latest Reviews Call BookMore Details
Red Roof Inn Columbia, SC Airport
+1-888-897-9207

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New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
2204 Airport Blvd., West Columbia, SC 29170 ~1.70 miles west of Cayce
  • Two star Airport hotel
  • 64 rooms in hotel
More Photos Image of Red Roof Inn Columbia, SC Airport
From$65
Average 3.0 /5 Guest Reviews Call BookMore Details
Sleep Inn Airport in West Columbia
+1-888-311-4278

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New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
2208 Airport Blvd., West Columbia, SC 29170 ~1.74 miles west of Cayce
  • Low priced Airport hotel
  • Check-in time: 2:00pm
More Photos Image of Sleep Inn Airport
From$60
Very Good 4.0 /5 Reviews Call BookMore Details
Country Inn & Suites Columbia Airport
+1-888-469-4795

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New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
2245 Airport Blvd., Cayce, SC 29033
  • Three Star Airport property
  • Hotel has 3 floors
More Photos Image of Country Inn & Suites Columbia Airport
From$65
Very Good 4.5 /5 Read Reviews Call BookMore Details
Days Inn & Suites by Wyndham Columbia Airport
+1-888-734-9421

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New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
110 Branch Rd., West Columbia, SC 29170 ~1.82 miles west of Cayce
  • 2-star Airport hotel
  • Check-in: 11:59 AM
More Photos Image of Days Inn & Suites by Wyndham Columbia Airport
From$60
Poor 2.0 /5 Hotel Reviews Call BookMore Details
Clarion Inn Airport West Columbia - West Columbia
+1-888-841-5292

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New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
29169, West Columbia, SC 29169 ~2.17 miles north of Cayce
  • Three Star Airport hotel
  • Fitness / Gym is on-site
More Photos Exterior of Clarion Inn Airport West Columbia
From$80
Average 3.0 /5 Latest Reviews Call BookMore Details
Quality Inn & Suites
+1-888-455-5160

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New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
3020 Charleston Highway, West Columbia, SC 29172 ~2.40 miles south of Cayce
  • 3-star Airport hotel
  • Check-in: 15:00
More Photos Photo of Quality Inn & Suites
From$80
Average 3.0 /5 Hotel Reviews Call BookMore Details
Courtyard by Marriott Columbia Cayce - Cayce
+1-888-965-8297

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1125 Fort Congaree Trail, Cayce, SC 29033
  • 3 star Highway property
  • 3 suites in hotel
More Photos Image of Courtyard by Marriott Columbia Cayce
From$99
Average 3.0 /5 Read Reviews Call BookMore Details
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Quality Inn Columbia Airport : 2516 Augusta Rd.
+1-888-906-6358

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New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
2516 Augusta Rd., West Columbia, SC 29169 Website ~2.53 miles northwest of Cayce
  • Low-priced Airport property
  • Check in time: 3:00
More Photos Photo of Quality Inn Columbia Airport
From$60
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Homewood Suites by Hilton Columbia Downtown in Columbia
+1-888-749-6785

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New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
400 Gervais St., Columbia, SC 29214 ~2.67 miles northeast of Cayce
  • Affordable hotel
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From$80
Average 3.0 /5 Reviews Call BookMore Details
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TRU by Hilton Columbia Downtown : 400a Gervais St.
+1-888-878-9982

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New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
400a Gervais St., Columbia, SC 29214 ~2.67 miles northeast of Cayce
  • Three Star hotel
  • Check in: 3:00PM
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From$80
Average 3.0 /5 Review Score Call BookMore Details
Clarion Inn Columbia Airport - West Columbia
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
500 Chris Dr., West Columbia, SC 29169 ~2.67 miles northwest of Cayce
  • Three Star Airport hotel
  • Hotel has 142 rooms
More Photos Exterior of Clarion Inn Columbia Airport
From$52
Very Good 4.0 /5 Review Score Call BookMore Details
Gallus Stadium Park Inn Ascend Hotel Collection in Columbia
+1-888-389-4121

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New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
621 South Assembly St., Columbia, SC 29201 ~2.80 miles east of Cayce
  • Two-star Downtown hotel
  • Check-in time: 3p.m.
More Photos Photo of Gallus Stadium Park Inn Ascend Hotel Collection
From$60
Average 3.0 /5 Review Score Call BookMore Details
SpringHill Suites by Marriott Columbia Downtown/The Vista
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
511 Lady St., Columbia, SC 29201 ~2.83 miles northeast of Cayce
  • 3 star Downtown property
  • 132 rooms in hotel
More Photos Exterior of SpringHill Suites by Marriott Columbia Downtown/The Vista
From$99
Very Good 4.0 /5 Read Reviews Call BookMore Details
Courtyard Columbia Downtown at Usc in Columbia
+1-800-716-8490

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New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
630 Assembly St., Columbia, SC 29201 ~2.95 miles northeast of Cayce
  • 3-star Downtown hotel
  • 9 floors in hotel
More Photos Exterior of Courtyard Columbia Downtown at Usc
From$80
Average 3.0 /5 Reviews Call BookMore Details
Hampton Inn Columbia-Downtown Historic District : 822 Gervais St.
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
822 Gervais St., Columbia, SC 29201 ~3.00 miles northeast of Cayce
  • Three Star Downtown property
  • 122 rooms in hotel
More Photos Image of Hampton Inn Columbia-Downtown Historic District
From$125
Very Good 4.5 /5 Hotel Reviews Call BookMore Details
Hilton Columbia Center : 924 Senate St.
+1-888-965-1860

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New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
924 Senate St., Columbia, SC 29201 ~3.01 miles northeast of Cayce
  • Four star Downtown property
  • 8 meeting rooms in hotel
More Photos Photo of Hilton Columbia Center
From$101
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Hyatt Place Columbia / Downtown / The Vista
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
819 Gervais St., Columbia, SC 29201 ~3.02 miles northeast of Cayce
  • 3 star Downtown property
  • Hotel has a green policy Learn more
More Photos Image of Hyatt Place Columbia / Downtown / The Vista
From$80
Average 3.0 /5 Hotel Reviews Call BookMore Details
Fairfield Inn & Suites Columbia Downtown
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
501 Taylor St., Columbia, SC 29201 ~3.05 miles north of Cayce
  • 3 star Downtown property
  • Gym / Fitness Center Available
More Photos Photo of Fairfield Inn & Suites Columbia Downtown
From$129
Average 3.0 /5 Reviews Call BookMore Details
Aloft by Marriott Columbia Downtown
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
823 Lady St., Columbia, SC 29201 ~3.06 miles northeast of Cayce
  • Affordable Downtown hotel
  • Check-in: 3:00pm
More Photos Image of Aloft by Marriott Columbia Downtown
From$80
Very Good 4.0 /5 Reviews Call BookMore Details
Holiday Inn Express & Suites Columbia Downtown – The Vista An Ih
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
901 Washington St., Columbia, SC 29201 ~3.18 miles northeast of Cayce
  • Mid-scale property
  • Check-in: 15:00
More Photos hotel room
From$90
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Cambria Hotel Columbia Downtown The Vista
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
1000 Lady St., Columbia, SC 29201 Website ~3.18 miles northeast of Cayce
  • 3-star Downtown hotel
  • 6 suites in hotel
More Photos Exterior of Cambria Hotel Columbia Downtown The Vista
From$99
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Staybridge Suites Columbia An Ihg Hotel - Columbia
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
1913 Huger St., Columbia, SC 29201 ~3.26 miles north of Cayce
  • Midscale Downtown hotel
  • Check-in: 3:00PM
More Photos Exterior of Staybridge Suites Columbia An Ihg Hotel
From$109
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Moxy Columbia : 1200 Main St.
+1-888-455-5160

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New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
1200 Main St., Columbia, SC 29201 Website ~3.31 miles northeast of Cayce
  • Midscale Downtown hotel
  • 128 rooms in property
More Photos Photo of Moxy Columbia
From$80
Average 3.0 /5 Hotel Reviews Call BookMore Details
Microtel : 1301 Main St.
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
1301 Main St., Columbia, SC 29201 ~3.33 miles northeast of Cayce
  • Cheap Downtown property
  • Complimentary breakfast is offered
More Photos hotel room
From$45
Average 3.0 /5 Review Score Call BookMore Details
Sheraton Columbia Downtown Hotel - Columbia
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
1400 Main St., Columbia, SC 29201 ~3.43 miles northeast of Cayce
  • Four-star Downtown hotel
  • Check in: 3:00pm
More Photos Image of Sheraton Columbia Downtown Hotel
From$129
Average 3.0 /5 Reviews Call BookMore Details
Holiday Inn Columbia Downtown in Columbia
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
1233 Washington St., Columbia, SC 29201 ~3.47 miles northeast of Cayce
  • 3 star Downtown hotel
  • Fitness center on property
More Photos Image of Holiday Inn Columbia Downtown
From$80
Average 3.0 /5 Guest Reviews Call BookMore Details
Marriott Columbia
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
1200 Hampton St., Columbia, SC 29201 ~3.48 miles northeast of Cayce
  • High-end Downtown hotel
  • 300 rooms in hotel
More Photos Image of Marriott Columbia
From$94
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Masters Inn Columbia I-26
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
2125 Commerce Dr., Cayce, NC 29033
  • Cheap property
More Photos Image of Masters Inn Columbia I-26
From$60
Poor 2.0 /5 Read Reviews Call BookMore Details
Extended Stay America Suites Columbia Greystone
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
180 Stoneridge Dr., Columbia, SC 29210 ~3.54 miles north of Cayce
  • Economy Downtown property
  • Free breakfast
More Photos Exterior of Extended Stay America Suites Columbia Greystone
From$35
Average 3.0 /5 Recent Reviews Call BookMore Details
Hotel Trundle
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
1224 Taylor St., Columbia, SC 29201 ~3.56 miles northeast of Cayce
  • Three Star Downtown property
  • Free comp. breakfast
More Photos Photo of Hotel Trundle
From$149
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Graduate by Hilton Columbia SC : 1619 Pendleton St.
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
1619 Pendleton St., Columbia, SC 29201 ~3.57 miles northeast of Cayce
  • High end Downtown property
  • 3 floors in hotel
More Photos Photo of Graduate by Hilton Columbia SC
From$129
Average 3.0 /5 Review Score Call BookMore Details
Extended Stay America Suites Columbia West Interstate 126 in Columbia
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
450 Gracern Rd., Columbia, SC 29210 ~3.57 miles north of Cayce
  • Economical hotel
  • Check-in: 3:00pm
More Photos Exterior of Extended Stay America Suites Columbia West Interstate 126
From$27
Poor 2.0 /5 Review Score Call BookMore Details
Hampton Inn I 26 Airport
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
1094 Chris Dr., West Columbia, SC 29169 ~3.61 miles northwest of Cayce
  • 3-star Highway hotel
  • Free complimentary breakfast
More Photos Image of Hampton Inn I 26 Airport
From$80
Average 3.0 /5 Latest Reviews Call BookMore Details
Embassy Suites Columbia
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
200 Stoneridge Dr., Columbia, SC 29210 ~3.65 miles north of Cayce
  • Affordable Suburban property
  • Hotel has a green policy Read more
More Photos Image of Embassy Suites Columbia
From$118
Very Good 4.0 /5 Recent Reviews Call BookMore Details
TRU by Hilton Columbia Greystone
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
185 Stoneridge Dr., Columbia, SC 29210 ~3.66 miles north of Cayce
  • Midscale Downtown hotel
  • 4 floors in hotel
More Photos Photo of TRU by Hilton Columbia Greystone
From$80
Average 3.0 /5 Guest Reviews Call BookMore Details
Carolina University Inn
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
1615 Gervais St., Columbia, SC 29201 ~3.66 miles northeast of Cayce
  • Mid-scale Downtown hotel
  • Has environment-friendly policy See more
More Photos Image of Carolina University Inn
From$59
Poor 2.5 /5 Review Score Call BookMore Details
Home2 Suites by Hilton Columbia Downtown
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
1609 Gervais St., Columbia, SC 29201 ~3.67 miles northeast of Cayce
  • 3 star property
  • 6 floors in hotel
More Photos Exterior of Home2 Suites by Hilton Columbia Downtown
From$80
Average 3.0 /5 Latest Reviews Call BookMore Details
Hilton Garden Inn Columbia Airport - West Columbia
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
110 Mcswain Dr., West Columbia, SC 29169 ~3.76 miles northwest of Cayce
  • Three Star Airport hotel
  • Check in time: 3:00 PM
More Photos Exterior of Hilton Garden Inn Columbia Airport
From$95
Very Good 4.0 /5 Review Score Call BookMore Details
Oyo Hotel Columbia Sc West : 114 Mcswain Dr.
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
114 Mcswain Dr., Columbia, SC 29169 ~3.86 miles northwest of Cayce
  • Affordable property
  • Check-in time: 15:00
More Photos Exterior of Oyo Hotel Columbia Sc West
From$90
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Homewood Suites by Hilton Columbia
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
230 Greystone Blvd., Columbia, SC 29210 ~3.91 miles north of Cayce
  • Midscale Downtown hotel
  • 81 suites in property
More Photos Image of Homewood Suites by Hilton Columbia
From$75
Average 3.0 /5 Read Reviews Call BookMore Details
Residence Inn by Marriott Columbia West / Lexington : 122 Mathias Rd.
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
122 Mathias Rd., West Columbia, SC 29169 ~4.07 miles northwest of Cayce
  • Three Star Highway property
  • 4 floors in property
More Photos Image of Residence Inn by Marriott Columbia West / Lexington
From$75
Average 3.0 /5 Guest Reviews Call BookMore Details
Towneplace Suites Columbia West / Lexington - West Columbia
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
2915 Sunset Blvd., West Columbia, SC 29169 ~4.18 miles northwest of Cayce
  • 3 star hotel
  • Gym / Fitness Center Available
More Photos Photo of Towneplace Suites Columbia West / Lexington
From$75
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Comfort Inn Columbia
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
911 Bush River Rd., Columbia, SC 29210 ~5.07 miles north of Cayce
  • Three Star Highway property
  • 99 sleeping rooms in hotel
More Photos Photo of Comfort Inn Columbia
From$62
Very Good 4.0 /5 Reviews Call BookMore Details
Days Inn by Wyndham Columbia
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
1144 Bush River Rd., Columbia, SC 29210 ~5.13 miles northwest of Cayce
  • Economical hotel
More Photos Photo of Days Inn by Wyndham Columbia
From$60
Not Good 1.0 /5 Hotel Reviews Call BookMore Details

Next: See My Cayce Hotels with Pricing

FAQs about hotels in Cayce

What are the best rated hotels in Cayce?

Hampton Inn Columbia-Downtown Historic District, Country Inn & Suites Columbia Airport and Marriott Columbia are the best rated hotels based on customer reviews in the last 365 days.

What are the most up-scale hotels in Cayce?

Marriott Columbia, Graduate by Hilton Columbia SC and Sheraton Columbia Downtown Hotel are the top 3 luxury hotels near Cayce city center.

What hotels are closest to the city center of Cayce?

Country Hearth Inn & Suites Cayce, Knights Inn Columbia Airport, and Econo Lodge Inn & Suites Cayce I-26 Airport are the properties closest to Cayce city center.

What are the best independent hotels in Cayce?

Hotel Trundle, Oyo Hotel Columbia Sc West and Carolina University Inn are the best rated independent hotels (not part of a big brand).

What are the best Marriott hotels in Cayce?

Marriott Columbia, Towneplace Suites Columbia West and SpringHill Suites by Marriott Columbia Downtown are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the best Choice Hotels branded hotels in Cayce?

Comfort Inn Columbia, Sleep Inn Airport and Clarion Inn Columbia Airport are the best rated Choice Hotels branded hotels (based on HotelPlanner reviews score).

What are the most popular IHG hotels in Cayce?

Staybridge Suites Columbia An Ihg Hotel, Holiday Inn Express & Suites Columbia Downtown – The Vista An Ih and Holiday Inn Columbia Downtown are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

Verified reviews of the city: Cayce, SC

Below are reviews of the city of Cayce, SC from an actual visitor's perspective.

"Great city with great people!"
Score 5.0 / 5

I used to live there. Great city with great people

Ella P., from 20-Sep-2025
"Great area"
Score 5.0 / 5

Charles A., from 05-Sep-2025
"Good Food!"
Score 5.0 / 5

How friendly everyone is and the good food.

Armon T., from 06-Feb-2024
"The people are courteous and very warm hearted."
Score 5.0 / 5

The people are courteous and very warm hearted.

Jeffrey W., from 05-Aug-2023
"Nice!"
Score 4.0 / 5

It was nice.

Robert P., from 16-Nov-2021
The average traveler rating of the city of Cayce, SC shown above is 4.8 out of 5 based on 5 reviews
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