Santee South Carolina Accommodations

Find the perfect hotel in Santee using our hotel guide provided below. Search for the cheapest discounted hotel and motel rates in or near Santee, SC for your upcoming personal or group trip. Discover the most favored Santee South Carolina hotel/motel rooms. Review the Santee hotel list below to find the perfect lodging. We also have a map of the Santee hotels. Coordinating a group? Get Santee Group Hotel Discounts

The Santee center point is around 2 miles from Lake Marion Resort and Marina and 18 miles from Edisto Memorial Gardens.

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Santee Hotels & Accommodations

Days Inn
+1-800-230-4134Check Rates
9074 Old Highway Six, Santee, SC 29142
  • Two-star hotel
Photo of Holiday Inn SanteeHoliday Inn Santee - Santee
+1-800-997-5148Check Rates
139 Bradford Blvd., Santee, SC 29142
  • 3.0/5, Average Recent Reviews
  • Affordable Highway hotel
  • Gym is available on property
Exterior of Comfort Inn & SuitesComfort Inn & Suites
+1-800-997-5149Check Rates
221 Britain St., Santee, SC 29142
Image of Quality Inn & SuitesQuality Inn & Suites - Santee
+1-800-230-4134Check Rates
8929 Old Number Six Highway, Santee, SC 29142
  • 3.0/5, Average Recent Reviews
  • Low Cost Highway property
  • 153 sleeping rooms in hotel
Photo of Howard Johnson SanteeHoward Johnson Santee
+1-800-997-5148Check Rates
249 Britain St., Santee, SC 29142
  • 3.0/5, Average Guest Reviews
  • Economical Golf Course hotel
  • Complimentary breakfast is offered
Image of Whitten InnWhitten Inn
+1-800-997-5149Check Rates
123 Mall St., Santee, SC 29142
  • 2.5/5, Poor Recent Reviews
  • Inexpensive Highway property
  • 117 sleeping rooms in hotel
Hampton Inn Santee I 95
+1-800-230-4134Check Rates
9060 Old #6 Highway, Santee, SC 29142
  • 4.5/5, Very Good Guest Reviews
  • 3-star Highway property
  • Complimentary breakfast is offered
Photo of Rodeway Inn SanteeRodeway Inn Santee
+1-800-997-5148Check Rates
9117 Old Number 6 Highway, Santee, SC 29142
  • 3.0/5, Average Hotel Reviews
  • Inexpensive Highway hotel
  • Free breakfast available
Best Western Plus Santee Inn
+1-800-997-5149Check Rates
9059 Old Number Six Highway, Santee, SC 29142
  • Affordable property
Travelodge in Santee
+1-800-230-4134Check Rates
9091 Old Highway 6, Santee, SC 29142
  • 2.5/5, Poor Reviews
  • Inexpensive Golf Course property
  • Hotel has 40 rooms
Econo Lodge in Santee
+1-800-997-5148Check Rates
9112 Old Number 6 Hww., Santee, SC 29142
  • Two star Highway property
  • Check in time: 02:00 PM
Peachtree Inn
+1-800-997-5149Check Rates
111 Conners Dr., Saint George, SC 29477
  • 4.5/5, Very Good Guest Reviews
  • 3-star Highway property
  • Hotel has 2 floors
~15.51 Miles from Santee
Sunset Inn Manning
+1-800-230-4134Check Rates
5932 Alex Highway, Manning, SC 29102~16.27 Miles from Santee
Hampton Inn
+1-800-997-5148Check Rates
2822 Paxville Highway, Manning, SC 29102
  • 4.5/5, Very Good Hotel Reviews
  • Mid-scale Highway property
  • 73 rooms in hotel
~19.30 Miles from Santee
Quality Inn in Manning
+1-800-997-5149Check Rates
3031 Paxville Highway, Manning, SC 29102~19.32 Miles from Santee
Country Inn & Suites : 731 Citadel Rd.
+1-800-230-4134Check Rates
731 Citadel Rd., Orangeburg, SC 29118
  • 3.5/5, Average Review Score
  • Low priced hotel
  • Check in: 3:00 pm
~19.66 Miles from Santee
Fairfield Inn Orangeburg in Orangeburg
+1-800-997-5148Check Rates
663 Citadel, Orangeburg, SC 29118~20.28 Miles from Santee
Comfort Inn & Suites in Orangeburg
+1-800-997-5149Check Rates
746 Citadel Rd., Orangeburg, SC 29118
  • 4.0/5, Very Good Reviews
  • Economical Rural property
  • 69 sleeping rooms in hotel
~20.37 Miles from Santee
Days Inn : 2825 Paxville Highway
+1-800-230-4134Check Rates
2825 Paxville Highway, Manning, SC 29102~20.47 Miles from Santee
Exterior of Southern LodgeSouthern Lodge
+1-800-997-5148Check Rates
3616 St. Matthews Rd., Orangeburg, SC 29118 Website
  • Low-priced Highway property
  • Hotel has an eco-friendly policy See policy
~20.48 Miles from Santee

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