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Santee South Carolina Accommodations

Find the perfect hotel in Santee using our hotel guide provided below. Search for the cheapest discounted hotel and motel rates in or near Santee, SC for your upcoming personal or group trip. Discover the most favored Santee South Carolina hotel/motel rooms. Review the Santee hotel list below to find the perfect lodging. We also have a map of the Santee hotels. Coordinating a group? Get Santee Group Hotel Discounts

The Santee center point is around 2 miles west of Lake Marion Resort and Marina and 18 miles east of Edisto Memorial Gardens.

Santee Hotels & Accommodations

Days Inn
+1-888-690-5281
9074 Old Highway Six, Santee, SC 29142
  • Low priced property
Holiday Inn Santee in Santee 139 Bradford Blvd., Santee, SC 29142
  • Affordable Highway property
  • Check-in: 4:00pm
Comfort Inn & Suites in Santee 221 Britain St., Santee, SC 29142
  • 2-star Lake property
  • Free complimentary breakfast
From$129
Average 3.5 /5Reviews Call
Quality Inn & Suites
+1-888-690-5247
8929 Old Number Six Highway, Santee, SC 29142
  • Inexpensive Highway hotel
  • Hotel has 2 floors
Howard Johnson Santee : 249 Britain St.
+1-888-305-3366
249 Britain St., Santee, SC 29142
  • Cheap Golf Course property
  • Check in time: 03:00pm
Whitten Inn - Santee
+1-800-997-5149
123 Mall St., Santee, SC 29142
  • Two-star Highway hotel
  • Check-in: 2:00 pm
Hampton Inn Santee I 95 - Santee
+1-888-690-5281
9060 Old #6 Highway, Santee, SC 29142
  • Mid-scale Highway hotel
  • Hotel has 7 suites
Rodeway Inn Santee
+1-800-230-4134
9117 Old Number 6 Highway, Santee, SC 29142
  • 2-star Highway hotel
  • Check in time: 02:00 PM
Best Western Plus Santee Inn
+1-800-997-5148
9059 Old Number Six Highway, Santee, SC 29142
  • Midscale property
From$88
Very Good 4.5 /5Review Score Call
Travelodge - Santee
+1-888-690-5247
9091 Old Highway 6, Santee, SC 29142
  • 2-star Golf Course property
  • 40 rooms in property
Econo Lodge - Santee
+1-888-305-3366
9112 Old Number 6 Hww., Santee, SC 29142
  • Low Cost Highway hotel
  • Check-in time: 02:00 PM
Peachtree Inn
+1-800-997-5149
111 Conners Dr., Saint George, SC 29477 ~15.51 miles south of Santee
  • Three Star Highway property
  • Check-in: 3.00
Sunset Inn Manning - Manning
+1-888-690-5281
5932 Alex Highway, Manning, SC 29102 ~16.27 miles northeast of Santee
  • 2 star property
Hampton Inn 2822 Paxville Highway, Manning, SC 29102 ~19.30 miles northeast of Santee
  • 3-star Highway hotel
  • Check in time: 2:00pm
From$90
Very Good 4.5 /5Read Reviews Call
Quality Inn - Manning
+1-800-997-5148
3031 Paxville Highway, Manning, SC 29102 ~19.32 miles northeast of Santee
  • 2-star hotel
Country Inn & Suites : 731 Citadel Rd.
+1-888-690-5247
731 Citadel Rd., Orangeburg, SC 29118 ~19.66 miles west of Santee
  • Cheap hotel
  • Hotel has 81 rooms
Fairfield Inn Orangeburg 663 Citadel Rd., Orangeburg, SC 29118 ~20.26 miles west of Santee
  • Affordable Highway property
  • Fitness + Health Center
From$89
Average 3.5 /5Reviews Call
Comfort Inn & Suites - Orangeburg 746 Citadel Rd., Orangeburg, SC 29118 ~20.37 miles west of Santee
  • Two star Rural hotel
  • Free breakfast
From$90
Very Good 4.0 /5Review Score Call
Hampton Inn & Suites Orangeburg - Orangeburg 749 Citadel Rd., Orangeburg, SC 29118 ~20.42 miles west of Santee
  • 3 star Highway hotel
  • 32 suites in hotel
From$119
Excellent 5.0 /5Review Score Call
Days Inn - Manning
+1-800-230-4134
2825 Paxville Highway, Manning, SC 29102 ~20.47 miles northeast of Santee
  • Cheap property
Southern Lodge - Orangeburg 3616 St. Matthews Rd., Orangeburg, SC 29118 ~20.48 miles west of Santee
  • Economical Highway property
  • Check-in time: 2.00pm
Sleep Inn Orangeburg : 3689 Saint Matthews Rd.
+1-888-690-5247
3689 Saint Matthews Rd., Orangeburg, SC 29118 ~20.49 miles west of Santee
  • 2-star Suburban property
  • Check in time: 2:00 PM
Quality Inn & Suites - Orangeburg 3671 St. Matthews, Orangeburg, SC 29118 ~20.51 miles west of Santee
  • Low Cost Rural property
  • 2 floors in property
Holiday Inn Express & Suites of Orangeburg in Orangeburg
+1-800-997-5149
118 Sleep Inn Rd., Orangeburg, SC 29118 ~20.51 miles west of Santee
  • Three Star Rural hotel
  • 3 floors in property
From$100
Very Good 4.0 /5Read Reviews Call
Howard Johnson
+1-888-690-5281
3608 St. Matthews Rd., Orangeburg, SC 29118 ~20.53 miles west of Santee
  • Two-star property
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