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Santee South Carolina Accommodations

Find the perfect hotel in Santee using our hotel guide provided below. Search for the cheapest discounted hotel and motel rates in or near Santee, SC for your upcoming personal or group trip. Discover the most favored Santee South Carolina hotel/motel rooms. Review the Santee hotel list below to find the perfect lodging. We also have a map of the Santee hotels. Coordinating a group? Get Santee Group Hotel Discounts

The Santee center point is around 2 miles west of Lake Marion Resort and Marina and 18 miles east of Edisto Memorial Gardens.

Santee Hotels/Accommodations

Days Inn 9074 Old Highway Six, Santee, SC 29142
  • Inexpensive hotel
Holiday Inn Santee 139 Bradford Blvd., Santee, SC 29142
  • 3 star Highway hotel
  • Check-in time: 3.00pm
Comfort Inn & Suites 221 Britain St., Santee, SC 29142
  • Cheap Lake hotel
  • Hotel has 20 suites
  • Quite clean
  • Rather comfortable
Quality Inn & Suites in Santee
+1-888-283-3404
8929 Old Number Six Highway, Santee, SC 29142
  • Two star Highway property
  • 2 meeting rooms in hotel
Red Roof Inn : 9091 Old No 6 Highway 9091 Old No 6 Highway, Santee, SC 29142
  • 2 star Golf Course property
  • Check-in: 1.00
Howard Johnson in Santee 249 Britain St., Santee, SC 29142
  • 2 star Golf Course property
  • 2 floors in hotel
Whitten Inn
+1-888-690-5281
123 Mall St., Santee, SC 29142
  • Cheap Highway property
  • 117 sleeping rooms in hotel
Hampton Inn Santee I 95 - Santee
+1-888-690-5247
9060 Old #6 Highway, Santee, SC 29142
  • Midscale Highway property
  • Free breakfast
  • Tasty breakfast
  • Most guests thought the building was wonderful
From$89
Very Good 4.5 /5Reviews CallBookMore Details
Best Western Plus Santee Inn - Santee I 95 Exit 98, Santee, SC 29142
  • 3 star property
  • 102 sleeping rooms in hotel
Econo Lodge - Santee 9112 Old Number 6 Highway, Santee, SC 29142
  • Cheap Highway property
  • 37 rooms in property
Rodeway Inn 9117 Old Number 6 Highway, Santee, SC 29142
  • Low Cost Highway hotel
  • Complimentary breakfast is offered
Days Inn Summerton 400 Buff Blvd., Summerton, SC 29148 ~10.34 miles northeast of Santee
  • Low priced property
Days Inn Orangeburg South in Orangeburg 3402 Five Chop Rd., Orangeburg, SC 29115 ~14.02 miles west of Santee
  • Economical Highway hotel
  • Check-in time: 2pm
Peachtree Inn 111 Conners Dr., Saint George, SC 29477 ~15.51 miles south of Santee
  • Affordable Highway hotel
  • Free breakfast available
Sunset Inn Manning : 5932 Alex Highway
+1-888-690-5247
5932 Alex Highway, Manning, SC 29102 ~16.27 miles northeast of Santee
  • Low Cost property
Hampton Inn 2822 Paxville Highway, Manning, SC 29102 ~19.30 miles northeast of Santee
  • Midscale Highway hotel
  • Gym / Fitness Center Available
Quality Inn - Manning 3031 Paxville Highway, Manning, SC 29102 ~19.32 miles northeast of Santee
  • Low-priced Golf Course hotel
  • Check-in: 2:00 pm
  • Poor, uncomfortable rooms
  • All guests thought they were poorly maintained
Fairfield Inn Orangeburg - Orangeburg 663 Citadel Rd., Orangeburg, SC 29118 ~20.26 miles west of Santee
  • Affordable Highway property
  • Free breakfast available
  • Most guests thought they were poorly maintained
  • Good continental breakfast
Country Inn & Suites Orangeburg 731 Citadel Rd., Orangeburg, SC 29118 ~20.37 miles west of Santee
  • Cheap property
  • 4 floors in hotel
Comfort Inn & Suites in Orangeburg 746 Citadel Rd., Orangeburg, SC 29118 ~20.37 miles west of Santee
  • Low Cost Rural property
  • Fitness center on property
  • Room was clean
  • Best value for money
From$90
Very Good 4.0 /5Read Reviews CallBookMore Details
Hampton Inn & Suites Orangeburg : 749 Citadel Rd. 749 Citadel Rd., Orangeburg, SC 29118 ~20.42 miles west of Santee
  • Midscale Highway hotel
  • Hotel has 32 suites
From$124
Very Good 4.5 /5Read Reviews CallBookMore Details
Days Inn
+1-888-690-5247
2825 Paxville Highway, Manning, SC 29102 ~20.47 miles northeast of Santee
  • Low Cost hotel
Southern Lodge 3616 St. Matthews Rd., Orangeburg, SC 29118 ~20.48 miles west of Santee
  • Inexpensive Highway hotel
  • 43 rooms in hotel
  • Breakfast is mediocre
  • Good accessibility by car
Travelodge Orangeburg : 3620 St. Matthews Rd. 3620 St. Matthews Rd., Orangeburg, SC 29118 ~20.48 miles west of Santee
  • Two star Highway property
  • Check-in time: 12:00 PM
Sleep Inn Orangeburg 3689 Saint Matthews Rd., Orangeburg, SC 29118 ~20.49 miles west of Santee
  • Two star Suburban property
  • 4 floors in hotel
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