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Santee South Carolina Accommodations

Find the perfect hotel in Santee using our hotel guide provided below. Search for the cheapest discounted hotel and motel rates in or near Santee, SC for your upcoming personal or group trip. Discover the most favored Santee South Carolina hotel/motel rooms. Review the Santee hotel list below to find the perfect lodging. We also have a map of the Santee hotels. Coordinating a group? Get Santee Group Hotel Discounts

The Santee center point is around 2 miles west of Lake Marion Resort and Marina and 18 miles east of Edisto Memorial Gardens.

Santee Hotels, Motels & Accommodations

Days Inn in Santee 9074 Old Highway Six, Santee, SC 29142
  • Inexpensive property
Holiday Inn Santee : 139 Bradford Blvd. 139 Bradford Blvd., Santee, SC 29142
  • 3 star Highway hotel
  • 84 rooms in property
Comfort Inn & Suites : 221 Britain St. 221 Britain St., Santee, SC 29142
  • Two-star Lake hotel
  • Check in time: 3:00 PM
Quality Inn & Suites - Santee
+1-888-690-5247
8929 Old Number Six Highway, Santee, SC 29142
  • Economy Highway property
  • 17 suites in property
Red Roof Inn 9091 Old No 6 Highway, Santee, SC 29142
  • Economical Golf Course property
  • Comp. Breakfast
Howard Johnson Santee : 249 Britain St. 249 Britain St., Santee, SC 29142
  • Low priced Golf Course hotel
  • Check in: 03:00pm
Whitten Inn
+1-800-997-5149
123 Mall St., Santee, SC 29142
  • Economical Highway property
  • Check in time: 2:00 pm
Hampton Inn Santee I 95 in Santee
+1-888-690-5281
9060 Old #6 Highway, Santee, SC 29142
  • Midscale Highway hotel
  • Hotel has 3 floors
Rodeway Inn Santee : 9117 Old Number 6 Highway
+1-800-230-4134
9117 Old Number 6 Highway, Santee, SC 29142
  • 2 star Highway hotel
  • Check-in: 02:00 PM
From$29
Average 3.0 /5Reviews Call
Best Western Plus Santee Inn 9059 Old Number Six Highway, Santee, SC 29142
  • Affordable property
Econo Lodge
+1-888-690-5247
9112 Old Number 6 Hww., Santee, SC 29142
  • Low priced Highway hotel
  • Free comp. breakfast
Peachtree Inn
+1-888-305-3366
111 Conners Dr., Saint George, SC 29477 ~15.51 miles south of Santee
  • 3-star Highway hotel
  • Free complimentary breakfast
From$49
Very Good 4.0 /5Review Score Call
Sunset Inn Manning - Manning
+1-800-881-1523
5932 Alex Highway, Manning, SC 29102 ~16.27 miles northeast of Santee
  • Economical hotel
Hampton Inn in Manning 2822 Paxville Highway, Manning, SC 29102 ~19.30 miles northeast of Santee
  • 3 star Highway property
  • Fitness center on property
From$90
Very Good 4.5 /5Review Score Call
Quality Inn - Manning 3031 Paxville Highway, Manning, SC 29102 ~19.32 miles northeast of Santee
  • Low-priced property
Country Inn & Suites
+1-800-230-4134
731 Citadel Rd., Orangeburg, SC 29118 ~19.66 miles west of Santee
  • Cheap property
  • Hotel has 28 suites
From$94
Average 3.5 /5Reviews Call
Fairfield Inn Orangeburg 663 Citadel Rd., Orangeburg, SC 29118 ~20.26 miles west of Santee
  • Affordable Highway hotel
  • 3 floors in property
Comfort Inn & Suites - Orangeburg 746 Citadel Rd., Orangeburg, SC 29118 ~20.37 miles west of Santee
  • Economy Rural property
  • Gym / Fitness Center Available
From$90
Very Good 4.0 /5Read Reviews Call
Hampton Inn & Suites Orangeburg - Orangeburg 749 Citadel Rd., Orangeburg, SC 29118 ~20.42 miles west of Santee
  • Affordable Highway property
  • Comp. Breakfast
From$119
Very Good 4.5 /5Latest Reviews Call
Days Inn - Manning
+1-800-881-1523
2825 Paxville Highway, Manning, SC 29102 ~20.47 miles northeast of Santee
  • Cheap hotel
Southern Lodge : 3616 St. Matthews Rd. 3616 St. Matthews Rd., Orangeburg, SC 29118 ~20.48 miles west of Santee
  • Cheap Highway hotel
  • 43 sleeping rooms in hotel
From$44
Very Good 4.0 /5Read Reviews Call
Sleep Inn Orangeburg in Orangeburg 3689 Saint Matthews Rd., Orangeburg, SC 29118 ~20.49 miles west of Santee
  • Low priced Suburban hotel
  • 4 floors in hotel
Quality Inn & Suites : 3671 St. Matthews 3671 St. Matthews, Orangeburg, SC 29118 ~20.51 miles west of Santee
  • Economy Rural property
  • 91 sleeping rooms in hotel
Holiday Inn Express & Suites of Orangeburg 118 Sleep Inn Rd., Orangeburg, SC 29118 ~20.51 miles west of Santee
  • Mid-scale Rural property
  • 78 sleeping rooms in hotel
Howard Johnson : 3608 St. Matthews Rd.
+1-888-690-5247
3608 St. Matthews Rd., Orangeburg, SC 29118 ~20.53 miles west of Santee
  • 2 star property
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