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Santee South Carolina Accommodations

Find the perfect hotel in Santee using our hotel guide provided below. Search for the cheapest discounted hotel and motel rates in or near Santee, SC for your upcoming personal or group trip. Discover the most favored Santee South Carolina hotel/motel rooms. Review the Santee hotel list below to find the perfect lodging. We also have a map of the Santee hotels. Coordinating a group? Get Santee Group Hotel Discounts

The Santee center point is around 2 miles west of Lake Marion Resort and Marina and 18 miles east of Edisto Memorial Gardens.

Santee Hotels/Accommodations

Days Inn - Santee 9074 Old Highway Six, Santee, SC 29142
  • Low-priced property
Holiday Inn Santee in Santee 139 Bradford Blvd., Santee, SC 29142
  • 3-star Highway hotel
  • Fitness + Health Center
Comfort Inn & Suites 221 Britain St., Santee, SC 29142
  • Low priced Lake hotel
  • 20 suites in hotel
  • Rooms clean
  • Excellent breakfast
Quality Inn & Suites - Santee
+1-888-690-5247
8929 Old Number Six Highway, Santee, SC 29142
  • Inexpensive Highway property
  • Free complimentary breakfast
Howard Johnson 249 Britain St., Santee, SC 29142
  • Economy Golf Course property
  • Check-in: 03:00pm
Red Roof Inn : 9091 Old No 6 Highway 9091 Old No 6 Highway, Santee, SC 29142
  • 2 star Golf Course hotel
  • Check in: 1.00
Whitten Inn - Santee
+1-888-283-3404
123 Mall St., Santee, SC 29142
  • Two-star Highway property
  • 117 rooms in hotel
Hampton Inn Santee I 95 : 9060 Old #6 Highway
+1-800-997-5149
9060 Old #6 Highway, Santee, SC 29142
  • Midscale Highway property
  • Comp. Breakfast
  • Great amenities
  • Noise level is acceptable
Best Western Plus Santee Inn - Santee 9059 Old Number Six Highway, Santee, SC 29142
  • Three Star hotel
  • 102 rooms in property
Econo Lodge 9112 Old Number 6 Highway, Santee, SC 29142
  • Low priced Highway property
  • Check-in time: 11:00
Rodeway Inn in Santee 9117 Old Number 6 Highway, Santee, SC 29142
  • Economical Highway property
  • Check in: 11:00
Days Inn Summerton 400 Buff Blvd., Summerton, SC 29148 ~10.34 miles northeast of Santee
  • Low Cost property
Days Inn Orangeburg South - Orangeburg 3402 Five Chop Rd., Orangeburg, SC 29115 ~14.02 miles west of Santee
  • Economy Highway property
  • Check-in time: 2pm
Peachtree Inn - Saint George 111 Conners Dr., Saint George, SC 29477 ~15.51 miles south of Santee
  • Affordable Highway hotel
  • 39 rooms in hotel
Sunset Inn Manning - Manning
+1-888-283-3404
5932 Alex Highway, Manning, SC 29102 ~16.27 miles northeast of Santee
  • Inexpensive hotel
Hampton Inn 2822 Paxville Highway, Manning, SC 29102 ~19.30 miles northeast of Santee
  • 3-star Highway property
  • 73 sleeping rooms in hotel
Quality Inn in Manning 3031 Paxville Highway, Manning, SC 29102 ~19.32 miles northeast of Santee
  • Cheap Golf Course property
  • 2 floors in property
  • Air conditioning did not work
  • Average beds
Fairfield Inn Orangeburg 663 Citadel Rd., Orangeburg, SC 29118 ~20.26 miles west of Santee
  • 3-star Highway hotel
  • Access to gym on-site
  • Friendly service
  • Most guests thought they were poorly maintained
Country Inn & Suites Orangeburg : 731 Citadel Rd. 731 Citadel Rd., Orangeburg, SC 29118 ~20.37 miles west of Santee
  • 2-star property
  • Check-in: 3:00 pm
Comfort Inn & Suites 746 Citadel Rd., Orangeburg, SC 29118 ~20.37 miles west of Santee
  • Two-star Rural property
  • 69 rooms in hotel
  • Most guests found the staff to be very friendly
  • Terrific location
Hampton Inn & Suites Orangeburg 749 Citadel Rd., Orangeburg, SC 29118 ~20.42 miles west of Santee
  • 3-star Highway property
  • Check in time: 3:00pm
From$124
Very Good 4.5 /5Recent Reviews Call
Days Inn in Manning
+1-800-881-1523
2825 Paxville Highway, Manning, SC 29102 ~20.47 miles northeast of Santee
  • Cheap property
Southern Lodge in Orangeburg 3616 St. Matthews Rd., Orangeburg, SC 29118 ~20.48 miles west of Santee
  • Cheap Highway hotel
  • Hotel has an eco-friendly policy See more
  • Breakfast is average
  • World class service
From$49
Very Good 4.0 /5Reviews Call
Sleep Inn Orangeburg : 3689 Saint Matthews Rd. 3689 Saint Matthews Rd., Orangeburg, SC 29118 ~20.49 miles west of Santee
  • Economy Suburban property
  • Free comp. breakfast
Days Inn Orangeburg : 3691 St. Matthews Rd.
+1-888-690-5281
3691 St. Matthews Rd., Orangeburg, SC 29118 ~20.50 miles west of Santee
  • 2 star Highway hotel
  • Check-in: 11:00 AM
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