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Santee South Carolina Accommodations

Find the perfect hotel in Santee using our hotel guide provided below. Search for the cheapest discounted hotel and motel rates in or near Santee, SC for your upcoming personal or group trip. Discover the most favored Santee South Carolina hotel/motel rooms. Review the Santee hotel list below to find the perfect lodging. We also have a map of the Santee hotels. Coordinating a group? Get Santee Group Hotel Discounts

The Santee center point is around 2 miles west of Lake Marion Resort and Marina and 18 miles east of Edisto Memorial Gardens.

Santee Hotels & Accommodations

Days Inn 9074 Old Highway Six, Santee, SC 29142
  • Low priced property
Holiday Inn Santee - Santee 139 Bradford Blvd., Santee, SC 29142
  • Three Star Highway hotel
  • Hotel has a green policy See policy
Comfort Inn & Suites 221 Britain St., Santee, SC 29142
  • Cheap Lake hotel
  • 20 suites in property
  • Free Wifi
  • Most guests complained about the bathroom
Quality Inn & Suites : 8929 Old Number Six Highway
+1-888-283-3404
8929 Old Number Six Highway, Santee, SC 29142
  • Economical Highway property
  • Hotel has 2 meeting rooms
Red Roof Inn 9091 Old No 6 Highway, Santee, SC 29142
  • Two star Golf Course property
  • Hotel has 40 rooms
Howard Johnson 249 Britain St., Santee, SC 29142
  • Low priced Golf Course hotel
  • Check in: 03:00pm
Whitten Inn
+1-888-690-5281
123 Mall St., Santee, SC 29142
  • 2 star Highway hotel
  • Free complimentary breakfast
Hampton Inn Santee I 95 in Santee 9060 Old #6 Highway, Santee, SC 29142
  • 3-star Highway hotel
  • 3 floors in property
  • Continental breakfast was amazing
  • Clean everything
From$106
Very Good 4.5 /5Recent Reviews CallBookMore Details
Best Western Plus Santee Inn - Santee I 95 Exit 98, Santee, SC 29142
  • Midscale property
  • Check-in: 01:00
From$80
Very Good 4.5 /5Reviews CallBookMore Details
Econo Lodge : 9112 Old Number 6 Highway 9112 Old Number 6 Highway, Santee, SC 29142
  • Cheap Highway property
  • Check-in time: 11:00
Rodeway Inn : 9117 Old Number 6 Highway 9117 Old Number 6 Highway, Santee, SC 29142
  • Cheap Highway hotel
  • Free comp. breakfast
Days Inn Summerton : 400 Buff Blvd. 400 Buff Blvd., Summerton, SC 29148 ~10.34 miles northeast of Santee
  • Inexpensive property
  • Check in time: 11:00 AM
Days Inn Orangeburg South in Orangeburg 3402 Five Chop Rd., Orangeburg, SC 29115 ~14.02 miles west of Santee
  • Economy Highway hotel
  • Hotel has 2 floors
Peachtree Inn 111 Conners Dr., Saint George, SC 29477 ~15.51 miles south of Santee
  • 3 star Highway property
  • Check in: 3.00
Sunset Inn Manning : 5932 Alex Highway
+1-888-690-5247
5932 Alex Highway, Manning, SC 29102 ~16.27 miles northeast of Santee
  • Low-priced property
From$50
Not Good 1.5 /5Reviews CallBookMore Details
Hampton Inn : 2822 Paxville Highway 2822 Paxville Highway, Manning, SC 29102 ~19.30 miles northeast of Santee
  • Affordable Highway property
  • 3 floors in property
Quality Inn - Manning 3031 Paxville Highway, Manning, SC 29102 ~19.32 miles northeast of Santee
  • Economy Golf Course hotel
  • 2 floors in hotel
  • Room cleanliness is acceptable
  • Beds were acceptable for 52%
Fairfield Inn Orangeburg 663 Citadel Rd., Orangeburg, SC 29118 ~20.26 miles west of Santee
  • Affordable Highway property
  • 3 floors in property
  • Access by car is easy and beds are comfortable
  • Clean rooms
Country Inn & Suites Orangeburg in Orangeburg 731 Citadel Rd., Orangeburg, SC 29118 ~20.37 miles west of Santee
  • Two star property
  • Complimentary breakfast is offered
Comfort Inn & Suites - Orangeburg 746 Citadel Rd., Orangeburg, SC 29118 ~20.37 miles west of Santee
  • Low Cost Rural property
  • Fitness center on property
  • Good Price
  • Fair breakfast prices
From$90
Very Good 4.0 /5Reviews CallBookMore Details
Hampton Inn & Suites Orangeburg 749 Citadel Rd., Orangeburg, SC 29118 ~20.42 miles west of Santee
  • Three Star Highway property
  • Gym is available on property
From$124
Very Good 4.5 /5Latest Reviews CallBookMore Details
Days Inn : 2825 Paxville Highway
+1-888-690-5247
2825 Paxville Highway, Manning, SC 29102 ~20.47 miles northeast of Santee
  • Cheap hotel
Southern Lodge in Orangeburg 3616 St. Matthews Rd., Orangeburg, SC 29118 ~20.48 miles west of Santee
  • Inexpensive Highway hotel
  • 43 rooms in property
  • Lots of restaurants
  • Professional service
Travelodge Orangeburg 3620 St. Matthews Rd., Orangeburg, SC 29118 ~20.48 miles west of Santee
  • 2-star Highway hotel
  • Check-in time: 12:00 PM
Sleep Inn Orangeburg 3689 Saint Matthews Rd., Orangeburg, SC 29118 ~20.49 miles west of Santee
  • Economical Suburban hotel
  • 4 floors in property
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