Santee South Carolina Accommodations

Find the perfect hotel in Santee using our hotel guide provided below. Search for the cheapest discounted hotel and motel rates in or near Santee, SC for your upcoming personal or group trip. Discover the most favored Santee South Carolina hotel/motel rooms. Review the Santee hotel list below to find the perfect lodging. We also have a map of the Santee hotels. Coordinating a group? Get Santee Group Hotel Discounts

The Santee center point is around 2 miles from Lake Marion Resort and Marina and 18 miles from Edisto Memorial Gardens.

Find my perfect hotel Rooms Check-In Check-Out  
Show Calendar Show Calendar Start My Search >
(select the discounts you qualify for)
Star Rating




Hotel Name

Price Range (USD)
to
Amenities







Set My Filter

Santee Hotels/Motels & Accommodations

Days Inn
+1-800-230-4134Check Rates
9074 Old Highway Six, Santee, SC 29142
  • Low-priced property
Photo of Holiday Inn SanteeHoliday Inn Santee
+1-800-997-5148Check Rates
139 Bradford Blvd., Santee, SC 29142
  • 3.0/5, Average Review Score
  • 3 star Highway hotel
  • Hotel has 84 rooms
Photo of Comfort Inn & SuitesComfort Inn & Suites - Santee
+1-800-997-5149Check Rates
221 Britain St., Santee, SC 29142
  • 4.0/5, Very Good Review Score
  • Low priced Lake property
  • Gym / Fitness Center Available
Exterior of Quality Inn & SuitesQuality Inn & Suites
+1-800-230-4134Check Rates
8929 Old Number Six Highway, Santee, SC 29142
  • 3.0/5, Average Review Score
  • Cheap Highway hotel
  • Free breakfast available
Photo of Howard Johnson SanteeHoward Johnson Santee
+1-800-997-5148Check Rates
249 Britain St., Santee, SC 29142
  • 3.0/5, Average Read Reviews
  • Cheap Golf Course property
  • Check-in time: 03:00pm
Exterior of Whitten InnWhitten Inn : 123 Mall St.
+1-800-997-5149Check Rates
123 Mall St., Santee, SC 29142
  • 2.5/5, Poor Recent Reviews
  • Low-priced Highway property
  • Hotel has 2 floors
Hampton Inn Santee I 95 - Santee
+1-800-230-4134Check Rates
9060 Old #6 Highway, Santee, SC 29142
  • 4.5/5, Very Good Latest Reviews
  • Mid-scale Highway property
  • 3 floors in property
Photo of Rodeway Inn SanteeRodeway Inn Santee
+1-800-997-5148Check Rates
9117 Old Number 6 Highway, Santee, SC 29142
  • 3.0/5, Average Hotel Reviews
  • Cheap Highway hotel
  • Check-in: 02:00 PM
Best Western Plus Santee Inn in Santee
+1-800-997-5149Check Rates
9059 Old Number Six Highway, Santee, SC 29142
  • 3 star hotel
Travelodge : 9091 Old Highway 6
+1-800-230-4134Check Rates
9091 Old Highway 6, Santee, SC 29142
  • 2.5/5, Poor Reviews
  • 2-star Golf Course hotel
  • Free breakfast
Econo Lodge in Santee
+1-800-997-5148Check Rates
9112 Old Number 6 Hww., Santee, SC 29142
  • Economy Highway property
  • Hotel has 37 rooms
Peachtree Inn in Saint George
+1-800-997-5149Check Rates
111 Conners Dr., Saint George, SC 29477
  • 4.5/5, Very Good Latest Reviews
  • Affordable Highway property
  • 2 floors in hotel
~15.51 Miles from Santee
Sunset Inn Manning : 5932 Alex Highway
+1-800-230-4134Check Rates
5932 Alex Highway, Manning, SC 29102~16.27 Miles from Santee
Hampton Inn in Manning
+1-800-997-5148Check Rates
2822 Paxville Highway, Manning, SC 29102
  • 4.5/5, Very Good Review Score
  • 3 star Highway hotel
  • 73 rooms in hotel
~19.30 Miles from Santee
Quality Inn in Manning
+1-800-997-5149Check Rates
3031 Paxville Highway, Manning, SC 29102~19.32 Miles from Santee
Country Inn & Suites in Orangeburg
+1-800-230-4134Check Rates
731 Citadel Rd., Orangeburg, SC 29118~19.66 Miles from Santee
Fairfield Inn Orangeburg
+1-800-997-5148Check Rates
663 Citadel, Orangeburg, SC 29118
  • 3.5/5, Average Read Reviews
  • 3 star hotel
  • Gym is available on property
~20.28 Miles from Santee
Comfort Inn & Suites
+1-800-997-5149Check Rates
746 Citadel Rd., Orangeburg, SC 29118
  • 4.0/5, Very Good Latest Reviews
  • Two star Rural hotel
  • 14 suites in property
~20.37 Miles from Santee
Days Inn
+1-800-230-4134Check Rates
2825 Paxville Highway, Manning, SC 29102~20.47 Miles from Santee
Image of Southern LodgeSouthern Lodge - Orangeburg
+1-800-997-5148Check Rates
3616 St. Matthews Rd., Orangeburg, SC 29118 Website
  • Economical Highway property
  • Has environment-friendly policy See policy
~20.48 Miles from Santee

 [1 - 20 of 50]   


Next: See My Santee Hotels with Pricing >