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Santee South Carolina Accommodations

Find the perfect hotel in Santee using our hotel guide provided below. Search for the cheapest discounted hotel and motel rates in or near Santee, SC for your upcoming personal or group trip. Discover the most favored Santee South Carolina hotel/motel rooms. Review the Santee hotel list below to find the perfect lodging. We also have a map of the Santee hotels. Coordinating a group? Get Santee Group Hotel Discounts

The Santee center point is around 2 miles west of Lake Marion Resort and Marina and 18 miles east of Edisto Memorial Gardens.

Santee Hotels/Motels & Accommodations

Days Inn : 9074 Old Highway Six 9074 Old Highway Six, Santee, SC 29142
  • Two-star hotel
Holiday Inn Santee 139 Bradford Blvd., Santee, SC 29142
  • Midscale Highway hotel
  • Hotel has 84 rooms
Comfort Inn & Suites 221 Britain St., Santee, SC 29142
  • Economical Lake hotel
  • 61 sleeping rooms in hotel
  • Bathroom drained slowly
  • Very good budget hotel
Quality Inn & Suites : 8929 Old Number Six Highway
+1-888-283-3404
8929 Old Number Six Highway, Santee, SC 29142
  • Economy Highway hotel
  • 2 meeting rooms in hotel
Howard Johnson - Santee 249 Britain St., Santee, SC 29142
  • Two star Golf Course property
  • Hotel has 2 floors
Red Roof Inn 9091 Old No 6 Highway, Santee, SC 29142
  • Low-priced Golf Course property
  • Hotel has 40 rooms
From$49
Average 3.5 /5Reviews CallBookMore Details
Whitten Inn in Santee
+1-888-690-5281
123 Mall St., Santee, SC 29142
  • Low priced Highway hotel
  • 117 sleeping rooms in hotel
Hampton Inn Santee I 95 - Santee
+1-888-690-5247
9060 Old #6 Highway, Santee, SC 29142
  • Three Star Highway hotel
  • 3 floors in hotel
  • Most guests complained about the bathroom
  • Rooms were clean, spacious
Best Western Plus Santee Inn : 9059 Old Number Six Highway 9059 Old Number Six Highway, Santee, SC 29142
  • Mid-scale property
  • Free complimentary breakfast
From$80
Very Good 4.5 /5Reviews CallBookMore Details
Econo Lodge in Santee 9112 Old Number 6 Highway, Santee, SC 29142
  • Cheap Highway hotel
  • Comp. Breakfast
Rodeway Inn in Santee 9117 Old Number 6 Highway, Santee, SC 29142
  • 2-star Highway hotel
  • Comp. Breakfast
Days Inn Summerton : 400 Buff Blvd. 400 Buff Blvd., Summerton, SC 29148 ~10.34 miles northeast of Santee
  • Economical hotel
  • Check in time: 11:00 AM
Days Inn Orangeburg South : 3402 Five Chop Rd. 3402 Five Chop Rd., Orangeburg, SC 29115 ~14.02 miles west of Santee
  • Low-priced Highway hotel
  • Check-in time: 2pm
Peachtree Inn - Saint George 111 Conners Dr., Saint George, SC 29477 ~15.51 miles south of Santee
  • Midscale Highway property
  • 39 sleeping rooms in hotel
From$49
Very Good 4.0 /5Reviews CallBookMore Details
Sunset Inn Manning - Manning
+1-888-690-5247
5932 Alex Highway, Manning, SC 29102 ~16.27 miles northeast of Santee
  • Two-star hotel
Hampton Inn in Manning 2822 Paxville Highway, Manning, SC 29102 ~19.30 miles northeast of Santee
  • 3-star Highway property
  • Free breakfast
From$90
Very Good 4.5 /5Review Score CallBookMore Details
Quality Inn 3031 Paxville Highway, Manning, SC 29102 ~19.32 miles northeast of Santee
  • 2-star Golf Course hotel
  • 60 rooms in property
  • Room cleanliness is acceptable
  • Ice machine was not working
From$69
Average 3.5 /5Reviews CallBookMore Details
Fairfield Inn Orangeburg 663 Citadel Rd., Orangeburg, SC 29118 ~20.26 miles west of Santee
  • Midscale Highway property
  • Gym / Fitness Center Available
  • Friendly check in staff
  • No room
Country Inn & Suites Orangeburg : 731 Citadel Rd. 731 Citadel Rd., Orangeburg, SC 29118 ~20.37 miles west of Santee
  • Cheap hotel
  • Hotel has 28 suites
Comfort Inn & Suites in Orangeburg 746 Citadel Rd., Orangeburg, SC 29118 ~20.37 miles west of Santee
  • Low-priced Rural hotel
  • Fitness center on property
  • For only 57%, the bathroom was ok
  • Clean
From$90
Very Good 4.0 /5Read Reviews CallBookMore Details
Hampton Inn & Suites Orangeburg : 749 Citadel Rd. 749 Citadel Rd., Orangeburg, SC 29118 ~20.42 miles west of Santee
  • 3 star Highway property
  • Check-in: 3:00pm
From$124
Very Good 4.5 /5Hotel Reviews CallBookMore Details
Days Inn
+1-888-690-5247
2825 Paxville Highway, Manning, SC 29102 ~20.47 miles northeast of Santee
  • Two-star hotel
Southern Lodge in Orangeburg 3616 St. Matthews Rd., Orangeburg, SC 29118 ~20.48 miles west of Santee
  • Two-star Highway property
  • 43 rooms in property
  • Most guests complained about the bathroom
  • Welcome with a smile
Travelodge Orangeburg in Orangeburg 3620 St. Matthews Rd., Orangeburg, SC 29118 ~20.48 miles west of Santee
  • Low priced Highway property
  • Check in time: 12:00 PM
Sleep Inn Orangeburg : 3689 Saint Matthews Rd. 3689 Saint Matthews Rd., Orangeburg, SC 29118 ~20.49 miles west of Santee
  • Inexpensive Suburban property
  • Hotel has 4 floors
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