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Santee South Carolina Accommodations

Find the perfect hotel in Santee using our hotel guide provided below. Search for the cheapest discounted hotel and motel rates in or near Santee, SC for your upcoming personal or group trip. Discover the most favored Santee South Carolina hotel/motel rooms. Review the Santee hotel list below to find the perfect lodging. We also have a map of the Santee hotels. Coordinating a group? Get Santee Group Hotel Discounts

The Santee center point is around 2 miles west of Lake Marion Resort and Marina and 18 miles east of Edisto Memorial Gardens.

Santee Hotels & Accommodations

Days Inn 9074 Old Highway Six, Santee, SC 29142
  • 2-star property
Holiday Inn Santee in Santee 139 Bradford Blvd., Santee, SC 29142
  • Mid-scale Highway property
  • Access to gym on-site
Comfort Inn & Suites - Santee 221 Britain St., Santee, SC 29142
  • Economy Lake property
  • 61 sleeping rooms in hotel
Quality Inn & Suites : 8929 Old Number Six Highway
+1-888-690-5247
8929 Old Number Six Highway, Santee, SC 29142
  • Inexpensive Highway hotel
  • Check in: 3:00PM
Howard Johnson Santee 249 Britain St., Santee, SC 29142
  • Two-star Golf Course property
  • Free comp. breakfast
Red Roof Inn Santee - Santee
+1-800-881-1523
9091 Old Highway 6, Santee, SC 29142
  • Low-priced Golf Course property
  • Free complimentary breakfast
Whitten Inn : 123 Mall St.
+1-800-997-5149
123 Mall St., Santee, SC 29142
  • Low Cost Highway hotel
  • 117 sleeping rooms in hotel
Hampton Inn Santee I 95
+1-888-690-5281
9060 Old #6 Highway, Santee, SC 29142
  • 3-star Highway hotel
  • 81 sleeping rooms in hotel
From$89
Very Good 4.5 /5Reviews Call
Rodeway Inn Santee in Santee
+1-800-230-4134
9117 Old Number 6 Highway, Santee, SC 29142
  • Cheap Highway property
  • Free breakfast available
Best Western Plus Santee Inn - Santee
+1-800-997-5148
9059 Old Number Six Highway, Santee, SC 29142
  • 3-star property
From$88
Very Good 4.5 /5Read Reviews Call
Econo Lodge - Santee
+1-888-690-5247
9112 Old Number 6 Hww., Santee, SC 29142
  • Two star Highway property
  • Free breakfast
From$75
Average 3.0 /5Reviews Call
Peachtree Inn : 111 Conners Dr.
+1-888-305-3366
111 Conners Dr., Saint George, SC 29477 ~15.51 miles south of Santee
  • Three Star Highway hotel
  • 2 floors in property
Sunset Inn Manning in Manning
+1-800-881-1523
5932 Alex Highway, Manning, SC 29102 ~16.27 miles northeast of Santee
  • Cheap property
Hampton Inn - Manning 2822 Paxville Highway, Manning, SC 29102 ~19.30 miles northeast of Santee
  • Affordable Highway hotel
  • Hotel has 73 rooms
Quality Inn in Manning 3031 Paxville Highway, Manning, SC 29102 ~19.32 miles northeast of Santee
  • 2-star property
Country Inn & Suites in Orangeburg
+1-800-230-4134
731 Citadel Rd., Orangeburg, SC 29118 ~19.66 miles west of Santee
  • 2-star hotel
  • Hotel has 4 floors
Fairfield Inn Orangeburg - Orangeburg 663 Citadel Rd., Orangeburg, SC 29118 ~20.26 miles west of Santee
  • 3-star Highway property
  • Fitness + Health Center
Comfort Inn & Suites in Orangeburg 746 Citadel Rd., Orangeburg, SC 29118 ~20.37 miles west of Santee
  • Low Cost Rural hotel
  • Check in time: 3 pm
Hampton Inn & Suites Orangeburg 749 Citadel Rd., Orangeburg, SC 29118 ~20.42 miles west of Santee
  • Affordable Highway hotel
  • 90 rooms in property
From$119
Very Good 4.5 /5Latest Reviews Call
Days Inn - Manning
+1-800-881-1523
2825 Paxville Highway, Manning, SC 29102 ~20.47 miles northeast of Santee
  • Low Cost hotel
Southern Lodge : 3616 St. Matthews Rd. 3616 St. Matthews Rd., Orangeburg, SC 29118 ~20.48 miles west of Santee
  • Economical Highway property
From$44
Very Good 4.0 /5Reviews Call
Sleep Inn Orangeburg in Orangeburg 3689 Saint Matthews Rd., Orangeburg, SC 29118 ~20.49 miles west of Santee
  • Economical Suburban hotel
  • Check-in time: 2:00 PM
Quality Inn & Suites : 3671 St. Matthews 3671 St. Matthews, Orangeburg, SC 29118 ~20.51 miles west of Santee
  • Low Cost Rural property
  • Check in: 3:00 PM
Holiday Inn Express & Suites of Orangeburg - Orangeburg 118 Sleep Inn Rd., Orangeburg, SC 29118 ~20.51 miles west of Santee
  • 3 star Rural hotel
  • Free comp. breakfast
Howard Johnson in Orangeburg
+1-888-690-5247
3608 St. Matthews Rd., Orangeburg, SC 29118 ~20.53 miles west of Santee
  • Economy hotel
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