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Santee South Carolina Accommodations

Find the perfect hotel in Santee using our hotel guide provided below. Search for the cheapest discounted hotel and motel rates in or near Santee, SC for your upcoming personal or group trip. Discover the most favored Santee South Carolina hotel/motel rooms. Review the Santee hotel list below to find the perfect lodging. We also have a map of the Santee hotels. Coordinating a group? Get Santee Group Hotel Discounts

The Santee center point is around 2 miles west of Lake Marion Resort and Marina and 18 miles east of Edisto Memorial Gardens.

Santee Hotels/Motels & Accommodations

Days Inn 9074 Old Highway Six, Santee, SC 29142
  • Low-priced hotel
Holiday Inn Santee in Santee 139 Bradford Blvd., Santee, SC 29142
  • Midscale Highway hotel
  • 84 rooms in property
Comfort Inn & Suites in Santee 221 Britain St., Santee, SC 29142
  • Low priced Lake property
  • Check-in: 3:00 PM
Quality Inn & Suites - Santee
+1-888-283-3404
8929 Old Number Six Highway, Santee, SC 29142
  • 2 star Highway hotel
  • Check-in time: 3:00PM
Red Roof Inn 9091 Old No 6 Highway, Santee, SC 29142
  • Two star Golf Course property
  • 40 sleeping rooms in hotel
Howard Johnson - Santee 249 Britain St., Santee, SC 29142
  • Inexpensive Golf Course property
  • Check-in: 03:00pm
Clarion Inn
+1-888-690-5281
123 Mall St., Santee, SC 29142
  • 3-star Highway property
  • 105 rooms in property
  • Almost all guests said the reception staff was great
  • Pillows stained
Hampton Inn Santee I 95 in Santee 9060 Old #6 Highway, Santee, SC 29142
  • Affordable Highway property
  • 81 rooms in property
  • Near lake and golf coarse
  • Room vacuumed
Best Western Plus Santee Inn : I 95 Exit 98 I 95 Exit 98, Santee, SC 29142
  • Low priced property
  • Check-in time: 01:00
Econo Lodge - Santee
+1-800-881-1523
9112 Old Number 6 Highway, Santee, SC 29142
  • Economical Highway hotel
  • 37 rooms in hotel
  • Bathroom could be optimized
  • Lumpy pillows
Rodeway Inn : 9117 Old Number 6 Highway 9117 Old Number 6 Highway, Santee, SC 29142
  • 2 star Highway hotel
  • Check in time: 11:00
Days Inn Summerton : 400 Buff Blvd. 400 Buff Blvd., Summerton, SC 29148 ~10.34 miles northeast of Santee
  • Economical property
  • Check in time: 11:00 AM
Americas Best Value Inn
+1-866-429-5787
401 Buff Blvd., Columbia, SC 29148 ~11.09 miles northeast of Santee
  • Low-priced property
  • 80 rooms in property
Days Inn Orangeburg South - Orangeburg 3402 Five Chop Rd., Orangeburg, SC 29115 ~14.02 miles west of Santee
  • Economy Highway property
  • Check in time: 2pm
Peachtree Inn : 111 Conners Dr. 111 Conners Dr., Saint George, SC 29477 ~15.51 miles south of Santee
  • 3 star Highway property
  • 39 rooms in hotel
From$49
Very Good 4.0 /5Reviews CallBookMore Details
Knights Inn Manning Sc 6137 Alex Harvin Highway, Manning, SC 29102 ~16.15 miles northeast of Santee
  • Two-star property
  • Check in time: 13:00
Sunset Inn Manning
+1-800-881-1523
5932 Alex Highway, Manning, SC 29102 ~16.27 miles northeast of Santee
  • Economical hotel
Hampton Inn 2822 Paxville Highway, Manning, SC 29102 ~19.30 miles northeast of Santee
  • Midscale Highway hotel
  • Free breakfast
Quality Inn 3031 Paxville Highway, Manning, SC 29102 ~19.32 miles northeast of Santee
  • 2 star Golf Course property
  • 60 rooms in property
  • Rooms are not good
  • Not very comfortable
Fairfield Inn Orangeburg 663 Citadel Rd., Orangeburg, SC 29118 Website ~20.26 miles west of Santee
  • 3-star Highway property
  • Check in time: 3:00 PM
  • Breakfast is mediocre
  • Beds were comfortable
Country Inns & Suites Orangeburg in Orangeburg 731 Citadel Rd., Orangeburg, SC 29118 ~20.37 miles west of Santee
  • Affordable Highway property
  • Hotel has 4 floors
From$103
Very Good 4.0 /5Guest Reviews CallBookMore Details
Comfort Inn & Suites : 746 Citadel Rd. 746 Citadel Rd., Orangeburg, SC 29118 ~20.37 miles west of Santee
  • 2 star Rural hotel
  • Free comp. breakfast
  • Great fridge
  • Comfort level is high
Hampton Inn & Suites Orangeburg - Orangeburg 749 Citadel Rd., Orangeburg, SC 29118 ~20.42 miles west of Santee
  • Mid-scale Highway hotel
  • Free breakfast available
From$119
Very Good 4.5 /5Reviews CallBookMore Details
Days Inn - Manning
+1-800-881-1523
2825 Paxville Highway, Manning, SC 29102 ~20.47 miles northeast of Santee
  • 2-star hotel
Southern Lodge - Orangeburg 3616 St. Matthews Rd., Orangeburg, SC 29118 ~20.48 miles west of Santee
  • 2 star Highway property
  • 43 rooms in property
  • Most guests thought the tv was sub-standard
  • Too small coffee cups
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