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Santee South Carolina Accommodations

Find the perfect hotel in Santee using our hotel guide provided below. Search for the cheapest discounted hotel and motel rates in or near Santee, SC for your upcoming personal or group trip. Discover the most favored Santee South Carolina hotel/motel rooms. Review the Santee hotel list below to find the perfect lodging. We also have a map of the Santee hotels. Coordinating a group? Get Santee Group Hotel Discounts

The Santee center point is around 2 miles west of Lake Marion Resort and Marina and 18 miles east of Edisto Memorial Gardens.

Santee Hotels, Motels & Accommodations

Days Inn 9074 Old Highway Six, Santee, SC 29142
  • Inexpensive hotel
Holiday Inn Santee - Santee 139 Bradford Blvd., Santee, SC 29142
  • Mid-scale Highway property
  • Hotel has an eco-friendly policy See policy
Comfort Inn & Suites 221 Britain St., Santee, SC 29142
  • 2-star Lake hotel
  • 61 sleeping rooms in hotel
  • Room cleanliness is acceptable
  • Copious breakfast
From$115
Average 3.5 /5Reviews CallBookMore Details
Quality Inn & Suites - Santee
+1-888-690-5247
8929 Old Number Six Highway, Santee, SC 29142
  • Cheap Highway property
  • 17 suites in hotel
Howard Johnson in Santee 249 Britain St., Santee, SC 29142
  • Two star Golf Course property
  • Complimentary breakfast is offered
From$75
Average 3.0 /5Reviews CallBookMore Details
Red Roof Inn in Santee 9091 Old No 6 Highway, Santee, SC 29142
  • Two-star Golf Course property
  • 40 sleeping rooms in hotel
Whitten Inn - Santee
+1-888-283-3404
123 Mall St., Santee, SC 29142
  • Low-priced Highway property
  • 117 rooms in hotel
Hampton Inn Santee I 95 : 9060 Old #6 Highway
+1-800-997-5149
9060 Old #6 Highway, Santee, SC 29142
  • Affordable Highway hotel
  • 3 floors in hotel
  • Most guests said the beds were comfortable
  • Staff are courteous and professional
Best Western Plus Santee Inn in Santee 9059 Old Number Six Highway, Santee, SC 29142
  • Three Star hotel
  • Check-in: 01:00
Econo Lodge 9112 Old Number 6 Highway, Santee, SC 29142
  • Cheap Highway hotel
  • 37 sleeping rooms in hotel
Rodeway Inn : 9117 Old Number 6 Highway 9117 Old Number 6 Highway, Santee, SC 29142
  • Inexpensive Highway hotel
  • Free breakfast
Days Inn Summerton in Summerton 400 Buff Blvd., Summerton, SC 29148 ~10.34 miles northeast of Santee
  • Low-priced property
  • Check-in: 11:00 AM
Days Inn Orangeburg South 3402 Five Chop Rd., Orangeburg, SC 29115 ~14.02 miles west of Santee
  • 2-star Highway hotel
  • Check-in: 2pm
Peachtree Inn in Saint George 111 Conners Dr., Saint George, SC 29477 ~15.51 miles south of Santee
  • Midscale Highway property
  • 2 floors in hotel
From$49
Very Good 4.0 /5Reviews CallBookMore Details
Sunset Inn Manning in Manning
+1-888-283-3404
5932 Alex Highway, Manning, SC 29102 ~16.27 miles northeast of Santee
  • Low-priced hotel
Hampton Inn - Manning 2822 Paxville Highway, Manning, SC 29102 ~19.30 miles northeast of Santee
  • Affordable Highway hotel
  • Fitness + Health Center
Quality Inn 3031 Paxville Highway, Manning, SC 29102 ~19.32 miles northeast of Santee
  • Two star Golf Course hotel
  • 2 floors in property
  • Good location
  • Bathroom could be optimized
From$63
Average 3.5 /5Reviews CallBookMore Details
Fairfield Inn Orangeburg 663 Citadel Rd., Orangeburg, SC 29118 ~20.26 miles west of Santee
  • Three Star Highway property
  • Check in time: 3:00 PM
  • Great reception
  • Easily accessible by car, said 80%
Country Inn & Suites Orangeburg - Orangeburg 731 Citadel Rd., Orangeburg, SC 29118 ~20.37 miles west of Santee
  • Two-star property
  • Free breakfast
Comfort Inn & Suites - Orangeburg 746 Citadel Rd., Orangeburg, SC 29118 ~20.37 miles west of Santee
  • Low Cost Rural hotel
  • Check-in: 3 pm
  • Great rate
  • Available for breakfast
From$90
Very Good 4.0 /5Read Reviews CallBookMore Details
Hampton Inn & Suites Orangeburg 749 Citadel Rd., Orangeburg, SC 29118 ~20.42 miles west of Santee
  • Three Star Highway property
  • Free breakfast
From$124
Very Good 4.5 /5Read Reviews CallBookMore Details
Days Inn - Manning
+1-800-881-1523
2825 Paxville Highway, Manning, SC 29102 ~20.47 miles northeast of Santee
  • Low Cost hotel
Southern Lodge 3616 St. Matthews Rd., Orangeburg, SC 29118 ~20.48 miles west of Santee
  • Economy Highway hotel
  • Hotel has a green policy Read more
  • Easily accessible by car, said 100%
  • Average sized rooms
Travelodge Orangeburg - Orangeburg 3620 St. Matthews Rd., Orangeburg, SC 29118 ~20.48 miles west of Santee
  • Cheap Highway hotel
  • 44 rooms in property
From$75
Average 3.5 /5Reviews CallBookMore Details
Sleep Inn Orangeburg 3689 Saint Matthews Rd., Orangeburg, SC 29118 ~20.49 miles west of Santee
  • Low-priced Suburban hotel
  • Free breakfast
From$94
Average 3.5 /5Reviews CallBookMore Details
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