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Santee South Carolina Accommodations

Find the perfect hotel in Santee using our hotel guide provided below. Search for the cheapest discounted hotel and motel rates in or near Santee, SC for your upcoming personal or group trip. Discover the most favored Santee South Carolina hotel/motel rooms. Review the Santee hotel list below to find the perfect lodging. We also have a map of the Santee hotels. Coordinating a group? Get Santee Group Hotel Discounts

The Santee center point is around 2 miles west of Lake Marion Resort and Marina and 18 miles east of Edisto Memorial Gardens.

Santee Hotels, Motels & Accommodations

Days Inn : 9074 Old Highway Six 9074 Old Highway Six, Santee, SC 29142
  • Economy hotel
Holiday Inn Santee 139 Bradford Blvd., Santee, SC 29142
  • Midscale Highway property
  • Hotel has 84 rooms
Comfort Inn & Suites in Santee 221 Britain St., Santee, SC 29142
  • Two star Lake property
  • Complimentary breakfast is offered
Quality Inn & Suites - Santee
+1-888-283-3404
8929 Old Number Six Highway, Santee, SC 29142
  • Cheap Highway property
  • Check-in time: 3:00PM
Howard Johnson - Santee 249 Britain St., Santee, SC 29142
  • Low priced Golf Course hotel
  • Free complimentary breakfast
Red Roof Inn in Santee 9091 Old No 6 Highway, Santee, SC 29142
  • 2-star Golf Course property
  • Check in: 1.00
Whitten Inn - Santee
+1-888-690-5281
123 Mall St., Santee, SC 29142
  • Economy Highway property
  • 2 floors in hotel
Hampton Inn Santee I 95 9060 Old #6 Highway, Santee, SC 29142
  • Three Star Highway hotel
  • Free comp. breakfast
  • Breakfast is delicious
  • Excellent pool
Best Western Plus Santee Inn I 95 Exit 98, Santee, SC 29142
  • Three Star property
  • 102 sleeping rooms in hotel
Econo Lodge 9112 Old Number 6 Highway, Santee, SC 29142
  • Economy Highway property
  • 37 rooms in property
Rodeway Inn in Santee 9117 Old Number 6 Highway, Santee, SC 29142
  • Low Cost Highway hotel
  • Check-in time: 11:00
Days Inn Summerton 400 Buff Blvd., Summerton, SC 29148 ~10.34 miles northeast of Santee
  • Low priced hotel
  • Check-in time: 11:00 AM
Americas Best Value Inn
+1-866-429-5787
401 Buff Blvd., Columbia, SC 29148 ~11.09 miles northeast of Santee
  • 2-star hotel
  • Check-in: 15:00
Days Inn Orangeburg South in Orangeburg 3402 Five Chop Rd., Orangeburg, SC 29115 ~14.02 miles west of Santee
  • 2-star Highway hotel
  • 95 rooms in property
From$60
Average 3.0 /5Reviews CallBookMore Details
Peachtree Inn - Saint George 111 Conners Dr., Saint George, SC 29477 ~15.51 miles south of Santee
  • 3 star Highway hotel
  • Complimentary breakfast is offered
From$49
Very Good 4.0 /5Read Reviews CallBookMore Details
Knights Inn Manning Sc : 6137 Alex Harvin Highway 6137 Alex Harvin Highway, Manning, SC 29102 ~16.15 miles northeast of Santee
  • Low-priced property
  • Check-in: 13:00
Sunset Inn Manning
+1-800-881-1523
5932 Alex Highway, Manning, SC 29102 ~16.27 miles northeast of Santee
  • Two star hotel
From$50
Not Good 1.0 /5Reviews CallBookMore Details
Hampton Inn in Manning 2822 Paxville Highway, Manning, SC 29102 ~19.30 miles northeast of Santee
  • 3-star Highway hotel
  • 73 rooms in hotel
From$90
Very Good 4.5 /5Reviews CallBookMore Details
Quality Inn 3031 Paxville Highway, Manning, SC 29102 ~19.32 miles northeast of Santee
  • Cheap Golf Course hotel
  • 60 rooms in hotel
  • Fridge did not work
  • Fantastic service
Fairfield Inn Orangeburg - Orangeburg 663 Citadel Rd., Orangeburg, SC 29118 Website ~20.26 miles west of Santee
  • Affordable Highway hotel
  • Free breakfast available
  • Good continental breakfast
  • Older building
Country Inn & Suites Orangeburg 731 Citadel Rd., Orangeburg, SC 29118 ~20.37 miles west of Santee
  • Inexpensive Highway hotel
  • Hotel has 4 floors
Comfort Inn & Suites in Orangeburg 746 Citadel Rd., Orangeburg, SC 29118 ~20.37 miles west of Santee
  • Two-star Rural property
  • 69 rooms in hotel
  • Modestly maintained rooms
  • Clean rooms
Hampton Inn & Suites Orangeburg in Orangeburg 749 Citadel Rd., Orangeburg, SC 29118 ~20.42 miles west of Santee
  • Mid-scale Highway hotel
  • Hotel has 90 rooms
From$124
Very Good 4.5 /5Guest Reviews CallBookMore Details
Days Inn - Manning
+1-800-881-1523
2825 Paxville Highway, Manning, SC 29102 ~20.47 miles northeast of Santee
  • 2-star property
Southern Lodge 3616 St. Matthews Rd., Orangeburg, SC 29118 ~20.48 miles west of Santee
  • Economical Highway property
  • 43 rooms in property
  • Most guests thought the tv was sub-standard
  • Welcome with a smile
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