Santee South Carolina Accommodations

Find the perfect hotel in Santee using our hotel guide provided below. Search for the cheapest discounted hotel and motel rates in or near Santee, SC for your upcoming personal or group trip. Discover the most favored Santee South Carolina hotel/motel rooms. Review the Santee hotel list below to find the perfect lodging. We also have a map of the Santee hotels. Coordinating a group? Get Santee Group Hotel Discounts

The Santee center point is around 2 miles from Lake Marion Resort and Marina and 18 miles from Edisto Memorial Gardens.

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Santee Hotels, Motels & Accommodations

Days Inn - Santee
+1-800-230-4134
$35+

9074 Old Highway Six, Santee, SC 29142
  • Two star property
Image of Holiday Inn SanteeHoliday Inn Santee - Santee
+1-800-997-5148
$93+

139 Bradford Blvd., Santee, SC 29142
  • 3.0/5, Average Reviews
  • Three Star Highway hotel
  • Hotel has 4 floors
Exterior of Comfort Inn & SuitesComfort Inn & Suites : 221 Britain St.
+1-800-997-5149
$80+

221 Britain St., Santee, SC 29142
  • 4.0/5, Very Good Latest Reviews
  • Two-star Lake hotel
  • Fitness + Health Center
Photo of Quality Inn & SuitesQuality Inn & Suites : 8929 Old Number Six Highway
+1-800-230-4134
$72+

8929 Old Number Six Highway, Santee, SC 29142
  • 3.0/5, Average Guest Reviews
  • Economy Highway hotel
  • Free breakfast available
Image of Howard Johnson SanteeHoward Johnson Santee
+1-800-997-5148
$40+

249 Britain St., Santee, SC 29142
  • 3.0/5, Average Read Reviews
  • Two-star Golf Course property
  • 60 rooms in property
Photo of Whitten InnWhitten Inn
+1-800-997-5149
$54+

123 Mall St., Santee, SC 29142
Hampton Inn Santee I 95 in Santee
+1-800-230-4134
$89+

9060 Old #6 Highway, Santee, SC 29142
  • 4.5/5, Very Good Reviews
  • Three Star Highway hotel
  • 81 rooms in hotel
Image of Rodeway Inn SanteeRodeway Inn Santee - Santee
+1-800-997-5148
$29+

9117 Old Number 6 Highway, Santee, SC 29142
  • 3.0/5, Average Guest Reviews
  • 2-star Highway hotel
  • Check in: 02:00 PM
Best Western Plus Santee Inn
+1-800-997-5149
$88+

9059 Old Number Six Highway, Santee, SC 29142
  • Midscale property
Travelodge - Santee
+1-800-230-4134
$75+

9091 Old Highway 6, Santee, SC 29142
  • 2.5/5, Poor Hotel Reviews
  • 2 star Golf Course hotel
  • Check-in time: 1.00
Econo Lodge
+1-800-997-5148
$75+

9112 Old Number 6 Hww., Santee, SC 29142
  • Low priced Highway hotel
  • Hotel has 37 rooms
Peachtree Inn
+1-800-997-5149
$49+

111 Conners Dr., Saint George, SC 29477
  • 4.5/5, Very Good Read Reviews
  • Three Star Highway hotel
  • Check-in time: 3.00
~15.51 Miles from Santee
Sunset Inn Manning
+1-800-230-4134
$50+

5932 Alex Highway, Manning, SC 29102~16.27 Miles from Santee
Hampton Inn
+1-800-997-5148
$80+

2822 Paxville Highway, Manning, SC 29102
  • 4.5/5, Very Good Guest Reviews
  • 3-star Highway hotel
  • Check in time: 2:00pm
~19.30 Miles from Santee
Quality Inn
+1-800-997-5149
$57+

3031 Paxville Highway, Manning, SC 29102~19.32 Miles from Santee
Country Inn & Suites
+1-800-230-4134
$94+

731 Citadel Rd., Orangeburg, SC 29118
  • 3.5/5, Average Hotel Reviews
  • Two-star property
  • 4 floors in property
~19.66 Miles from Santee
Fairfield Inn Orangeburg
+1-800-997-5148
$90+

663 Citadel, Orangeburg, SC 29118~20.28 Miles from Santee
Comfort Inn & Suites : 746 Citadel Rd.
+1-800-997-5149
$89+

746 Citadel Rd., Orangeburg, SC 29118~20.37 Miles from Santee
Days Inn : 2825 Paxville Highway
+1-800-230-4134
$63+

2825 Paxville Highway, Manning, SC 29102~20.47 Miles from Santee
Image of Southern LodgeSouthern Lodge - Orangeburg
+1-800-997-5148
$58+

3616 St. Matthews Rd., Orangeburg, SC 29118 Website
  • Low Cost Highway property
  • Hotel has an eco-friendly policy See policy
~20.48 Miles from Santee

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