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Santee South Carolina Accommodations

Find the perfect hotel in Santee using our hotel guide provided below. Search for the cheapest discounted hotel and motel rates in or near Santee, SC for your upcoming personal or group trip. Discover the most favored Santee South Carolina hotel/motel rooms. Review the Santee hotel list below to find the perfect lodging. We also have a map of the Santee hotels. Coordinating a group? Get Santee Group Hotel Discounts

The Santee center point is around 2 miles west of Lake Marion Resort and Marina and 18 miles east of Edisto Memorial Gardens.

Santee Hotels, Motels & Accommodations

Days Inn 9074 Old Highway Six, Santee, SC 29142
  • Low-priced hotel
Holiday Inn Santee - Santee 139 Bradford Blvd., Santee, SC 29142
  • Three Star Highway property
  • 4 floors in hotel
Comfort Inn & Suites : 221 Britain St. 221 Britain St., Santee, SC 29142
  • 2 star Lake property
  • 20 suites in hotel
  • Nice bed
  • Excellent breakfast
Quality Inn & Suites - Santee
+1-888-690-5247
8929 Old Number Six Highway, Santee, SC 29142
  • Cheap Highway hotel
  • 2 conference rooms in property
Red Roof Inn 9091 Old No 6 Highway, Santee, SC 29142
  • Economical Golf Course property
  • Check-in: 1.00
Howard Johnson : 249 Britain St. 249 Britain St., Santee, SC 29142
  • Low Cost Golf Course hotel
  • 60 sleeping rooms in hotel
Whitten Inn - Santee
+1-888-283-3404
123 Mall St., Santee, SC 29142
  • Cheap Highway property
  • Check-in: 2:00 pm
Hampton Inn Santee I 95 in Santee
+1-800-997-5149
9060 Old #6 Highway, Santee, SC 29142
  • 3 star Highway hotel
  • 7 suites in hotel
  • Most guests found the staff to be very friendly
  • Great linens
From$89
Very Good 4.5 /5Reviews Call
Rodeway Inn Santee
+1-888-690-5281
9117 Old Number 6 Highway, Santee, SC 29142
  • Low priced Highway hotel
  • Free breakfast
  • Clean building
  • Most guests thought the shower was ok
Best Western Plus Santee Inn - Santee 9059 Old Number Six Highway, Santee, SC 29142
  • 3 star property
From$80
Very Good 4.5 /5Review Score Call
Econo Lodge : 9112 Old Number 6 Hww.
+1-800-997-5148
9112 Old Number 6 Hww., Santee, SC 29142
  • Low Cost Highway property
  • Comp. Breakfast
Peachtree Inn in Saint George 111 Conners Dr., Saint George, SC 29477 ~15.51 miles south of Santee
  • 3-star Highway hotel
  • 2 floors in property
From$49
Very Good 4.0 /5Reviews Call
Sunset Inn Manning
+1-888-305-3366
5932 Alex Highway, Manning, SC 29102 ~16.27 miles northeast of Santee
  • Low-priced property
From$50
Terrible 1.5 /5Reviews Call
Hampton Inn : 2822 Paxville Highway 2822 Paxville Highway, Manning, SC 29102 ~19.30 miles northeast of Santee
  • 3 star Highway property
  • Hotel has 73 rooms
From$90
Very Good 4.5 /5Read Reviews Call
Quality Inn - Manning 3031 Paxville Highway, Manning, SC 29102 ~19.32 miles northeast of Santee
  • Two star Golf Course property
  • 60 rooms in property
  • Quite clean
  • Good location
Fairfield Inn Orangeburg 663 Citadel Rd., Orangeburg, SC 29118 ~20.26 miles west of Santee
  • Three Star Highway hotel
  • 3 floors in property
  • Most guests complained about the bathroom
  • Terrible amenities
Country Inn & Suites Orangeburg 731 Citadel Rd., Orangeburg, SC 29118 ~20.37 miles west of Santee
  • Economical hotel
  • Check in: 3:00 pm
Comfort Inn & Suites 746 Citadel Rd., Orangeburg, SC 29118 ~20.37 miles west of Santee
  • Cheap Rural hotel
  • Free breakfast available
  • Fair breakfast prices
  • Convenient to highway
Hampton Inn & Suites Orangeburg - Orangeburg 749 Citadel Rd., Orangeburg, SC 29118 ~20.42 miles west of Santee
  • Affordable Highway property
  • Hotel has 90 rooms
From$119
Very Good 4.5 /5Hotel Reviews Call
Days Inn
+1-888-690-5247
2825 Paxville Highway, Manning, SC 29102 ~20.47 miles northeast of Santee
  • Cheap property
Southern Lodge 3616 St. Matthews Rd., Orangeburg, SC 29118 ~20.48 miles west of Santee
  • Economy Highway property
  • Hotel has a green policy Learn more
  • Fair Hotel
  • No breakfast
From$49
Very Good 4.0 /5Read Reviews Call
Sleep Inn Orangeburg - Orangeburg 3689 Saint Matthews Rd., Orangeburg, SC 29118 ~20.49 miles west of Santee
  • 2 star Suburban hotel
  • Free breakfast available
  • Rather comfortable
  • Restful night sleep
Quality Inn & Suites 3671 St. Matthews, Orangeburg, SC 29118 ~20.51 miles west of Santee
  • Low priced Rural hotel
  • Check-in time: 3:00 PM
Holiday Inn Express & Suites of Orangeburg 118 Sleep Inn Rd., Orangeburg, SC 29118 ~20.51 miles west of Santee
  • 3 star Rural property
  • Access to gym on-site
  • Bed comfortable
  • Staff was friendly
From$109
Very Good 4.0 /5Latest Reviews Call
Howard Johnson
+1-888-690-5281
3608 St. Matthews Rd., Orangeburg, SC 29118 ~20.53 miles west of Santee
  • Economy hotel
  • Free continental breakfast
  • AC was not working
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