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Santee South Carolina Accommodations

Find the perfect hotel in Santee using our hotel guide provided below. Search for the cheapest discounted hotel and motel rates in or near Santee, SC for your upcoming personal or group trip. Discover the most favored Santee South Carolina hotel/motel rooms. Review the Santee hotel list below to find the perfect lodging. We also have a map of the Santee hotels. Coordinating a group? Get Santee Group Hotel Discounts

The Santee center point is around 2 miles west of Lake Marion Resort and Marina and 18 miles east of Edisto Memorial Gardens.

Santee Hotels/Accommodations

Days Inn - Santee 9074 Old Highway Six, Santee, SC 29142
  • Low priced hotel
Holiday Inn Santee in Santee 139 Bradford Blvd., Santee, SC 29142
  • Three Star Highway property
  • 4 floors in property
From$99
Average 3.5 /5Reviews Call
Comfort Inn & Suites in Santee 221 Britain St., Santee, SC 29142
  • Inexpensive Lake property
  • Check in: 3:00 PM
  • Tasty breakfast
  • Free Wifi
Quality Inn & Suites - Santee
+1-888-690-5247
8929 Old Number Six Highway, Santee, SC 29142
  • 2 star Highway hotel
  • Hotel has 17 suites
Red Roof Inn 9091 Old No 6 Highway, Santee, SC 29142
  • Economy Golf Course hotel
  • Hotel has 40 rooms
Howard Johnson in Santee 249 Britain St., Santee, SC 29142
  • Cheap Golf Course hotel
  • Check in time: 03:00pm
Whitten Inn
+1-888-283-3404
123 Mall St., Santee, SC 29142
  • Low Cost Highway property
  • 117 rooms in hotel
Hampton Inn Santee I 95 : 9060 Old #6 Highway
+1-800-997-5149
9060 Old #6 Highway, Santee, SC 29142
  • Midscale Highway hotel
  • Check-in time: 3:00 pm
  • Near beautiful lake
  • Clean rooms
Rodeway Inn Santee - Santee
+1-888-690-5281
9117 Old Number 6 Highway, Santee, SC 29142
  • Economy Highway hotel
  • Check in: 02:00 PM
  • Rooms in need of an update
  • Most guests thought the building wasn't nice
Best Western Plus Santee Inn - Santee 9059 Old Number Six Highway, Santee, SC 29142
  • Midscale property
  • Check in time: 01:00
Econo Lodge
+1-800-997-5148
9112 Old Number 6 Hww., Santee, SC 29142
  • Two-star Highway property
  • Check-in: 02:00 PM
Days Inn Summerton 400 Buff Blvd., Summerton, SC 29148 ~10.34 miles northeast of Santee
  • Inexpensive property
Days Inn Orangeburg South 3402 Five Chop Rd., Orangeburg, SC 29115 ~14.02 miles west of Santee
  • Low priced hotel
  • Check-in: 11:00 AM
Peachtree Inn 111 Conners Dr., Saint George, SC 29477 ~15.51 miles south of Santee
  • Three Star Highway property
  • Hotel has 39 rooms
Sunset Inn Manning : 5932 Alex Highway
+1-888-283-3404
5932 Alex Highway, Manning, SC 29102 ~16.27 miles northeast of Santee
  • 2-star hotel
Hampton Inn 2822 Paxville Highway, Manning, SC 29102 ~19.30 miles northeast of Santee
  • Three Star Highway property
  • 73 rooms in property
Quality Inn 3031 Paxville Highway, Manning, SC 29102 ~19.32 miles northeast of Santee
  • 2 star Golf Course property
  • Hotel has 60 rooms
  • Good location
  • Fridge did not work
Fairfield Inn Orangeburg 663 Citadel Rd., Orangeburg, SC 29118 ~20.26 miles west of Santee
  • 3 star Highway hotel
  • 3 floors in hotel
  • Room was clean and comfortable
  • Air conditioning did not work
From$109
Very Good 4.0 /5Reviews Call
Country Inn & Suites Orangeburg : 731 Citadel Rd. 731 Citadel Rd., Orangeburg, SC 29118 ~20.37 miles west of Santee
  • Cheap property
  • 81 rooms in hotel
Comfort Inn & Suites - Orangeburg 746 Citadel Rd., Orangeburg, SC 29118 ~20.37 miles west of Santee
  • 2 star Rural hotel
  • Hotel has 69 rooms
  • Choice of restaurants nearby
  • Clean room
From$90
Very Good 4.0 /5Review Score Call
Hampton Inn & Suites Orangeburg in Orangeburg 749 Citadel Rd., Orangeburg, SC 29118 ~20.42 miles west of Santee
  • Midscale Highway property
  • 4 floors in hotel
From$119
Excellent 5.0 /5Review Score Call
Days Inn : 2825 Paxville Highway
+1-800-881-1523
2825 Paxville Highway, Manning, SC 29102 ~20.47 miles northeast of Santee
  • Low Cost hotel
Southern Lodge 3616 St. Matthews Rd., Orangeburg, SC 29118 ~20.48 miles west of Santee
  • Low Cost Highway hotel
  • Check-in: 2.00pm
  • Easily accessible by car, said 100%
  • Poorly cleaned rooms with uncomfortable furniture
From$49
Very Good 4.0 /5Review Score Call
Sleep Inn Orangeburg 3689 Saint Matthews Rd., Orangeburg, SC 29118 ~20.49 miles west of Santee
  • Economy Suburban property
  • 4 floors in property
  • Room is all right
  • Friendly staff
Days Inn Orangeburg
+1-888-690-5281
3691 St. Matthews Rd., Orangeburg, SC 29118 ~20.50 miles west of Santee
  • Inexpensive Highway property
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