Santee South Carolina Accommodations

Find the perfect hotel in Santee using our hotel guide provided below. Search for the cheapest discounted hotel and motel rates in or near Santee, SC for your upcoming personal or group trip. Discover the most favored Santee South Carolina hotel/motel rooms. Review the Santee hotel list below to find the perfect lodging. We also have a map of the Santee hotels. Coordinating a group? Get Santee Group Hotel Discounts

The Santee center point is around 2 miles from Lake Marion Resort and Marina and 18 miles from Edisto Memorial Gardens.

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Santee Hotels/Accommodations

Days Inn
+1-800-230-4134Check Rates
9074 Old Highway Six, Santee, SC 29142
  • Cheap property
Image of Holiday Inn SanteeHoliday Inn Santee in Santee
+1-800-997-5148Check Rates
139 Bradford Blvd., Santee, SC 29142
Photo of Comfort Inn & SuitesComfort Inn & Suites
+1-800-997-5149Check Rates
221 Britain St., Santee, SC 29142
  • 4.0/5, Very Good Guest Reviews
  • Two star Lake hotel
  • Check in: 3:00 PM
Image of Quality Inn & SuitesQuality Inn & Suites
+1-800-230-4134Check Rates
8929 Old Number Six Highway, Santee, SC 29142
  • 3.0/5, Average Read Reviews
  • Economy Highway hotel
  • 153 rooms in hotel
Image of Howard Johnson SanteeHoward Johnson Santee : 249 Britain St.
+1-800-997-5148Check Rates
249 Britain St., Santee, SC 29142
  • 3.0/5, Average Latest Reviews
  • Low Cost Golf Course hotel
  • Hotel has 2 floors
Photo of Whitten InnWhitten Inn
+1-800-997-5149Check Rates
123 Mall St., Santee, SC 29142
  • 2.5/5, Poor Guest Reviews
  • 2 star Highway property
  • Free comp. breakfast
Hampton Inn Santee I 95 in Santee
+1-800-230-4134Check Rates
9060 Old #6 Highway, Santee, SC 29142
  • 4.5/5, Very Good Reviews
  • 3 star Highway property
  • Hotel has 3 floors
Photo of Rodeway Inn SanteeRodeway Inn Santee
+1-800-997-5148Check Rates
9117 Old Number 6 Highway, Santee, SC 29142
  • 3.0/5, Average Latest Reviews
  • Low priced Highway hotel
  • Free complimentary breakfast
Best Western Plus Santee Inn
+1-800-997-5149Check Rates
9059 Old Number Six Highway, Santee, SC 29142
  • Mid-scale hotel
Travelodge : 9091 Old Highway 6
+1-800-230-4134Check Rates
9091 Old Highway 6, Santee, SC 29142
  • 2.5/5, Poor Recent Reviews
  • Two-star Golf Course hotel
  • Free breakfast available
Econo Lodge - Santee
+1-800-997-5148Check Rates
9112 Old Number 6 Hww., Santee, SC 29142
  • Low priced Highway hotel
  • Free breakfast available
Peachtree Inn in Saint George
+1-800-997-5149Check Rates
111 Conners Dr., Saint George, SC 29477
  • 4.5/5, Very Good Reviews
  • Mid-scale Highway property
  • 39 sleeping rooms in hotel
~15.51 Miles from Santee
Sunset Inn Manning
+1-800-230-4134Check Rates
5932 Alex Highway, Manning, SC 29102
  • 1.5/5, Terrible Reviews
  • Two-star property
~16.27 Miles from Santee
Hampton Inn in Manning
+1-800-997-5148Check Rates
2822 Paxville Highway, Manning, SC 29102
  • 4.5/5, Very Good Hotel Reviews
  • Three Star Highway property
  • 73 sleeping rooms in hotel
~19.30 Miles from Santee
Quality Inn - Manning
+1-800-997-5149Check Rates
3031 Paxville Highway, Manning, SC 29102~19.32 Miles from Santee
Country Inn & Suites : 731 Citadel Rd.
+1-800-230-4134Check Rates
731 Citadel Rd., Orangeburg, SC 29118
  • 3.5/5, Average Review Score
  • Economical hotel
  • Free comp. breakfast
~19.66 Miles from Santee
Fairfield Inn Orangeburg : 663 Citadel
+1-800-997-5148Check Rates
663 Citadel, Orangeburg, SC 29118
  • 3.5/5, Average Latest Reviews
  • Midscale property
  • Free complimentary breakfast
~20.28 Miles from Santee
Comfort Inn & Suites - Orangeburg
+1-800-997-5149Check Rates
746 Citadel Rd., Orangeburg, SC 29118
  • 4.0/5, Very Good Hotel Reviews
  • Low Cost Rural property
  • 69 rooms in property
~20.37 Miles from Santee
Days Inn : 2825 Paxville Highway
+1-800-230-4134Check Rates
2825 Paxville Highway, Manning, SC 29102~20.47 Miles from Santee
Exterior of Southern LodgeSouthern Lodge
+1-800-997-5148Check Rates
3616 St. Matthews Rd., Orangeburg, SC 29118 Website
  • 2-star Highway property
  • Check-in: 2.00pm
~20.48 Miles from Santee

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