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Santee South Carolina Accommodations

Find the perfect hotel in Santee using our hotel guide provided below. Search for the cheapest discounted hotel and motel rates in or near Santee, SC for your upcoming personal or group trip. Discover the most favored Santee South Carolina hotel/motel rooms. Review the Santee hotel list below to find the perfect lodging. We also have a map of the Santee hotels. Coordinating a group? Get Santee Group Hotel Discounts

The Santee center point is around 2 miles west of Lake Marion Resort and Marina and 18 miles east of Edisto Memorial Gardens.

Santee Hotels/Motels & Accommodations

Days Inn 9074 Old Highway Six, Santee, SC 29142
  • Low-priced hotel
Holiday Inn Santee in Santee 139 Bradford Blvd., Santee, SC 29142
  • Midscale Highway hotel
  • Hotel has an eco-friendly policy Read more
Comfort Inn & Suites 221 Britain St., Santee, SC 29142
  • Two star Lake property
  • Check in time: 3:00 PM
Quality Inn & Suites - Santee
+1-888-690-5247
8929 Old Number Six Highway, Santee, SC 29142
  • Low-priced Highway property
  • Check-in: 3:00PM
Red Roof Inn 9091 Old No 6 Highway, Santee, SC 29142
  • Two star Golf Course property
  • Free complimentary breakfast
Howard Johnson Santee in Santee 249 Britain St., Santee, SC 29142
  • Low Cost Golf Course hotel
  • Check-in: 03:00pm
Whitten Inn : 123 Mall St.
+1-800-997-5149
123 Mall St., Santee, SC 29142
  • Inexpensive Highway property
  • 2 floors in hotel
Hampton Inn Santee I 95
+1-888-690-5281
9060 Old #6 Highway, Santee, SC 29142
  • 3 star Highway hotel
  • 3 floors in hotel
Best Western Plus Santee Inn : 9059 Old Number Six Highway
+1-800-230-4134
9059 Old Number Six Highway, Santee, SC 29142
  • 3 star property
From$88
Very Good 4.5 /5Reviews Call
Rodeway Inn Santee : 9117 Old Number 6 Highway
+1-800-997-5148
9117 Old Number 6 Highway, Santee, SC 29142
  • Low-priced Highway hotel
  • Check in: 02:00 PM
From$29
Average 3.0 /5Reviews Call
Econo Lodge : 9112 Old Number 6 Hww.
+1-888-690-5247
9112 Old Number 6 Hww., Santee, SC 29142
  • Cheap Highway hotel
  • Check-in time: 02:00 PM
Peachtree Inn
+1-888-305-3366
111 Conners Dr., Saint George, SC 29477 ~15.51 miles south of Santee
  • 3 star Highway property
  • Free breakfast
From$49
Very Good 4.0 /5Reviews Call
Sunset Inn Manning - Manning
+1-800-881-1523
5932 Alex Highway, Manning, SC 29102 ~16.27 miles northeast of Santee
  • Inexpensive hotel
Hampton Inn : 2822 Paxville Highway 2822 Paxville Highway, Manning, SC 29102 ~19.30 miles northeast of Santee
  • Mid-scale Highway hotel
  • Fitness / Gym is on-site
From$90
Very Good 4.5 /5Review Score Call
Quality Inn - Manning 3031 Paxville Highway, Manning, SC 29102 ~19.32 miles northeast of Santee
  • 2 star property
Country Inn & Suites - Orangeburg
+1-800-230-4134
731 Citadel Rd., Orangeburg, SC 29118 ~19.66 miles west of Santee
  • Economy hotel
  • 28 suites in hotel
From$94
Average 3.5 /5Reviews Call
Fairfield Inn Orangeburg : 663 Citadel Rd. 663 Citadel Rd., Orangeburg, SC 29118 ~20.26 miles west of Santee
  • 3 star Highway property
  • 3 floors in hotel
From$109
Average 3.5 /5Reviews Call
Comfort Inn & Suites : 746 Citadel Rd. 746 Citadel Rd., Orangeburg, SC 29118 ~20.37 miles west of Santee
  • Low Cost Rural hotel
  • 69 sleeping rooms in hotel
From$90
Very Good 4.0 /5Reviews Call
Hampton Inn & Suites Orangeburg : 749 Citadel Rd. 749 Citadel Rd., Orangeburg, SC 29118 ~20.42 miles west of Santee
  • 3-star Highway hotel
  • Hotel has 90 rooms
From$119
Very Good 4.5 /5Reviews Call
Days Inn - Manning
+1-800-881-1523
2825 Paxville Highway, Manning, SC 29102 ~20.47 miles northeast of Santee
  • Low Cost property
Southern Lodge 3616 St. Matthews Rd., Orangeburg, SC 29118 ~20.48 miles west of Santee
  • 2-star Highway property
  • 43 rooms in hotel
Sleep Inn Orangeburg : 3689 Saint Matthews Rd. 3689 Saint Matthews Rd., Orangeburg, SC 29118 ~20.49 miles west of Santee
  • Two star Suburban hotel
  • Free breakfast available
Quality Inn & Suites : 3671 St. Matthews 3671 St. Matthews, Orangeburg, SC 29118 ~20.51 miles west of Santee
  • Two star Rural hotel
  • Free complimentary breakfast
Holiday Inn Express & Suites of Orangeburg : 118 Sleep Inn Rd. 118 Sleep Inn Rd., Orangeburg, SC 29118 ~20.51 miles west of Santee
  • Mid-scale Rural property
  • 12 suites in property
Howard Johnson : 3608 St. Matthews Rd.
+1-888-690-5247
3608 St. Matthews Rd., Orangeburg, SC 29118 ~20.53 miles west of Santee
  • Economy hotel
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