Santee South Carolina Accommodations

Find the perfect hotel in Santee using our hotel guide provided below. Search for the cheapest discounted hotel and motel rates in or near Santee, SC for your upcoming personal or group trip. Discover the most favored Santee South Carolina hotel/motel rooms. Review the Santee hotel list below to find the perfect lodging. We also have a map of the Santee hotels. Coordinating a group? Get Santee Group Hotel Discounts

The Santee center point is around 2 miles from Lake Marion Resort and Marina and 18 miles from Edisto Memorial Gardens.

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Santee Hotels & Accommodations

Days Inn : 9074 Old Highway Six
+1-800-230-4134Check Rates
9074 Old Highway Six, Santee, SC 29142
  • Low Cost hotel
Exterior of Holiday Inn SanteeHoliday Inn Santee
+1-800-997-5148Check Rates
139 Bradford Blvd., Santee, SC 29142
  • 3.0/5, Average Recent Reviews
  • Midscale Highway property
  • Check in: 4:00pm
Exterior of Comfort Inn & SuitesComfort Inn & Suites - Santee
+1-800-997-5149Check Rates
221 Britain St., Santee, SC 29142
  • 4.0/5, Very Good Reviews
  • Economy Lake property
  • Gym / Fitness Center Available
Photo of Quality Inn & SuitesQuality Inn & Suites : 8929 Old Number Six Highway
+1-800-230-4134Check Rates
8929 Old Number Six Highway, Santee, SC 29142
  • 3.0/5, Average Guest Reviews
  • Two-star Highway hotel
  • 153 sleeping rooms in hotel
Exterior of Howard Johnson SanteeHoward Johnson Santee
+1-800-997-5148Check Rates
249 Britain St., Santee, SC 29142
  • 3.0/5, Average Hotel Reviews
  • Cheap Golf Course hotel
  • 60 rooms in hotel
Photo of Whitten InnWhitten Inn : 123 Mall St.
+1-800-997-5149Check Rates
123 Mall St., Santee, SC 29142
  • 2.5/5, Poor Guest Reviews
  • Low Cost Highway property
  • Check in: 2:00 pm
Hampton Inn Santee I 95 : 9060 Old #6 Highway
+1-800-230-4134Check Rates
9060 Old #6 Highway, Santee, SC 29142
  • 4.5/5, Very Good Latest Reviews
  • Mid-scale Highway property
  • 81 rooms in hotel
Best Western Plus Santee Inn - Santee
+1-800-997-5148Check Rates
9059 Old Number Six Highway, Santee, SC 29142
  • Three Star property
Rodeway Inn Santee : 9117 Old Number 6 Highway
+1-800-997-5149Check Rates
9117 Old Number 6 Highway, Santee, SC 29142
Travelodge - Santee
+1-800-230-4134Check Rates
9091 Old Highway 6, Santee, SC 29142
  • 2.5/5, Poor Hotel Reviews
  • Economy Golf Course hotel
  • 40 rooms in hotel
Econo Lodge - Santee
+1-800-997-5148Check Rates
9112 Old Number 6 Hww., Santee, SC 29142
  • Two star Highway hotel
  • Check-in: 02:00 PM
Peachtree Inn - Saint George
+1-800-997-5149Check Rates
111 Conners Dr., Saint George, SC 29477
  • 4.5/5, Very Good Review Score
  • 3 star Highway hotel
  • Comp. Breakfast
~15.51 Miles from Santee
Sunset Inn Manning in Manning
+1-800-230-4134Check Rates
5932 Alex Highway, Manning, SC 29102~16.27 Miles from Santee
Hampton Inn
+1-800-997-5148Check Rates
2822 Paxville Highway, Manning, SC 29102
  • 4.5/5, Very Good Recent Reviews
  • 3-star Highway property
  • 3 floors in property
~19.30 Miles from Santee
Quality Inn
+1-800-997-5149Check Rates
3031 Paxville Highway, Manning, SC 29102~19.32 Miles from Santee
Country Inn & Suites in Orangeburg
+1-800-230-4134Check Rates
731 Citadel Rd., Orangeburg, SC 29118
  • 3.5/5, Average Latest Reviews
  • Low-priced property
  • 81 sleeping rooms in hotel
~19.66 Miles from Santee
Fairfield Inn Orangeburg : 663 Citadel
+1-800-997-5148Check Rates
663 Citadel, Orangeburg, SC 29118~20.28 Miles from Santee
Comfort Inn & Suites in Orangeburg
+1-800-997-5149Check Rates
746 Citadel Rd., Orangeburg, SC 29118
  • 4.0/5, Very Good Read Reviews
  • Low Cost Rural hotel
  • Hotel has 69 rooms
~20.37 Miles from Santee
Days Inn : 2825 Paxville Highway
+1-800-230-4134Check Rates
2825 Paxville Highway, Manning, SC 29102~20.47 Miles from Santee
Photo of Southern LodgeSouthern Lodge
+1-800-997-5148Check Rates
3616 St. Matthews Rd., Orangeburg, SC 29118 Website
  • Economical Highway property
  • 43 rooms in property
~20.48 Miles from Santee

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