Santee South Carolina Accommodations

Find the perfect hotel in Santee using our hotel guide provided below. Search for the cheapest discounted hotel and motel rates in or near Santee, SC for your upcoming personal or group trip. Discover the most favored Santee South Carolina hotel/motel rooms. Review the Santee hotel list below to find the perfect lodging. We also have a map of the Santee hotels. Coordinating a group? Get Santee Group Hotel Discounts


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Santee Hotels/Motels & Accommodations

Days Inn
+1-800-230-4134
$35+

9074 Old Highway Six, Santee, SC 29142
  • 2 star hotel
Photo of Holiday Inn SanteeHoliday Inn Santee
+1-800-997-5148
$93+

139 Bradford Blvd., Santee, SC 29142
  • 3.0/5, Average Reviews
  • Three Star Highway property
  • Check-in time: 4:00pm
Photo of Comfort Inn & SuitesComfort Inn & Suites in Santee
+1-800-997-5149
$80+

221 Britain St., Santee, SC 29142
  • 3.5/5, Average Read Reviews
  • 2-star Lake hotel
  • 20 suites in property
Photo of Quality Inn & SuitesQuality Inn & Suites - Santee
+1-800-230-4134
$72+

8929 Old Number Six Highway, Santee, SC 29142
  • 3.0/5, Average Reviews
  • Low priced Highway property
  • 153 sleeping rooms in hotel
Image of Howard Johnson SanteeHoward Johnson Santee
+1-800-997-5148
$40+

249 Britain St., Santee, SC 29142
  • 3.0/5, Average Reviews
  • Two-star Golf Course hotel
  • Free complimentary breakfast
Photo of Whitten InnWhitten Inn : 123 Mall St.
+1-800-997-5149
$54+

123 Mall St., Santee, SC 29142
  • 2.5/5, Poor Guest Reviews
  • Cheap Highway property
  • Hotel has 117 rooms
Hampton Inn Santee I 95 in Santee
+1-800-230-4134
$89+

9060 Old #6 Highway, Santee, SC 29142
  • 4.5/5, Very Good Review Score
  • Affordable Highway hotel
  • 3 floors in hotel
Photo of Rodeway Inn SanteeRodeway Inn Santee in Santee
+1-800-997-5148
$29+

9117 Old Number 6 Highway, Santee, SC 29142
Best Western Plus Santee Inn - Santee
+1-800-997-5149
$88+

9059 Old Number Six Highway, Santee, SC 29142
  • Midscale property
Travelodge - Santee
+1-800-230-4134
$75+

9091 Old Highway 6, Santee, SC 29142
  • 3.5/5, Average Review Score
  • Economical Golf Course property
  • Complimentary breakfast is offered
Econo Lodge in Santee
+1-800-997-5148
$75+

9112 Old Number 6 Hww., Santee, SC 29142
  • Low Cost Highway hotel
  • 37 sleeping rooms in hotel
Peachtree Inn - Saint George
+1-800-997-5149
$49+

111 Conners Dr., Saint George, SC 29477
  • 4.5/5, Very Good Review Score
  • 3 star Highway hotel
  • Check in time: 3.00
~15.51 Miles from Santee
Sunset Inn Manning : 5932 Alex Highway
+1-800-230-4134
$50+

5932 Alex Highway, Manning, SC 29102
  • 1.5/5, Terrible Reviews
  • Economical property
~16.27 Miles from Santee
Hampton Inn
+1-800-997-5148
$80+

2822 Paxville Highway, Manning, SC 29102
  • 4.5/5, Very Good Read Reviews
  • 3 star Highway hotel
  • 73 rooms in property
~19.30 Miles from Santee
Quality Inn : 3031 Paxville Highway
+1-800-997-5149
$57+

3031 Paxville Highway, Manning, SC 29102~19.32 Miles from Santee
Country Inn & Suites
+1-800-230-4134
$94+

731 Citadel Rd., Orangeburg, SC 29118~19.66 Miles from Santee
Fairfield Inn Orangeburg in Orangeburg
+1-800-997-5148
$90+

663 Citadel, Orangeburg, SC 29118
  • 3.5/5, Average Recent Reviews
  • Mid-scale hotel
  • Gym is available on property
~20.28 Miles from Santee
Comfort Inn & Suites : 746 Citadel Rd.
+1-800-997-5149
$89+

746 Citadel Rd., Orangeburg, SC 29118
  • 4.0/5, Very Good Review Score
  • 2 star Rural hotel
  • Complimentary breakfast is offered
~20.37 Miles from Santee
Days Inn : 2825 Paxville Highway
+1-800-230-4134
$63+

2825 Paxville Highway, Manning, SC 29102~20.47 Miles from Santee
Exterior of Southern LodgeSouthern Lodge
+1-800-997-5148
$58+

3616 St. Matthews Rd., Orangeburg, SC 29118 Website
  • Low-priced Highway property
  • Hotel has 43 rooms
~20.48 Miles from Santee

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