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Santee South Carolina Accommodations

Find the perfect hotel in Santee using our hotel guide provided below. Search for the cheapest discounted hotel and motel rates in or near Santee, SC for your upcoming personal or group trip. Discover the most favored Santee South Carolina hotel/motel rooms. Review the Santee hotel list below to find the perfect lodging. We also have a map of the Santee hotels. Coordinating a group? Get Santee Group Hotel Discounts

The Santee center point is around 2 miles west of Lake Marion Resort and Marina and 18 miles east of Edisto Memorial Gardens.

Santee Hotels, Motels & Accommodations

Days Inn 9074 Old Highway Six, Santee, SC 29142
  • Economical hotel
Holiday Inn Santee : 139 Bradford Blvd. 139 Bradford Blvd., Santee, SC 29142
  • 3 star Highway property
  • Check-in time: 3.00pm
Comfort Inn & Suites 221 Britain St., Santee, SC 29142
  • Cheap Lake hotel
  • Fitness + Health Center
  • Fantastic service
  • Bathroom could be optimized
Quality Inn & Suites
+1-888-283-3404
8929 Old Number Six Highway, Santee, SC 29142
  • Low-priced Highway property
  • Check-in time: 3:00PM
Red Roof Inn - Santee 9091 Old No 6 Highway, Santee, SC 29142
  • Cheap Golf Course property
  • Free comp. breakfast
Howard Johnson - Santee 249 Britain St., Santee, SC 29142
  • Two star Golf Course property
  • 60 sleeping rooms in hotel
Whitten Inn : 123 Mall St.
+1-888-690-5281
123 Mall St., Santee, SC 29142
  • Economical Highway hotel
  • 3 meeting rooms in hotel
Hampton Inn Santee I 95 in Santee 9060 Old #6 Highway, Santee, SC 29142
  • Midscale Highway property
  • Check in: 3:00 pm
  • Clean rooms
  • Comfort level is high
From$106
Very Good 4.5 /5Read Reviews CallBookMore Details
Best Western Plus Santee Inn I 95 Exit 98, Santee, SC 29142
  • Affordable property
  • Free breakfast
Econo Lodge - Santee 9112 Old Number 6 Highway, Santee, SC 29142
  • Two-star Highway property
  • Check-in time: 11:00
Rodeway Inn 9117 Old Number 6 Highway, Santee, SC 29142
  • Inexpensive Highway hotel
  • Free comp. breakfast
Days Inn Summerton in Summerton 400 Buff Blvd., Summerton, SC 29148 ~10.34 miles northeast of Santee
  • Low priced hotel
  • Check-in time: 11:00 AM
Days Inn Orangeburg South 3402 Five Chop Rd., Orangeburg, SC 29115 ~14.02 miles west of Santee
  • Economy Highway hotel
  • 2 floors in property
Peachtree Inn : 111 Conners Dr. 111 Conners Dr., Saint George, SC 29477 ~15.51 miles south of Santee
  • Midscale Highway hotel
  • 2 floors in hotel
Sunset Inn Manning
+1-888-690-5247
5932 Alex Highway, Manning, SC 29102 ~16.27 miles northeast of Santee
  • Low priced property
Hampton Inn in Manning 2822 Paxville Highway, Manning, SC 29102 ~19.30 miles northeast of Santee
  • Mid-scale Highway property
  • Check in: 2:00pm
From$90
Very Good 4.5 /5Reviews CallBookMore Details
Quality Inn : 3031 Paxville Highway 3031 Paxville Highway, Manning, SC 29102 ~19.32 miles northeast of Santee
  • Economy Golf Course property
  • Check in time: 2:00 pm
  • Fridge did not work
  • Air conditioning did not work
Fairfield Inn Orangeburg 663 Citadel Rd., Orangeburg, SC 29118 ~20.26 miles west of Santee
  • Three Star Highway hotel
  • Hotel has 3 floors
  • Clean
  • Friendly staff
Country Inn & Suites Orangeburg 731 Citadel Rd., Orangeburg, SC 29118 ~20.37 miles west of Santee
  • Two star hotel
  • Hotel has 28 suites
Comfort Inn & Suites in Orangeburg 746 Citadel Rd., Orangeburg, SC 29118 ~20.37 miles west of Santee
  • Low-priced Rural hotel
  • Gym / Fitness Center Available
  • Rather comfortable
  • Friendly service
From$90
Very Good 4.0 /5Review Score CallBookMore Details
Hampton Inn & Suites Orangeburg - Orangeburg 749 Citadel Rd., Orangeburg, SC 29118 ~20.42 miles west of Santee
  • 3-star Highway hotel
  • 4 floors in property
From$124
Very Good 4.5 /5Recent Reviews CallBookMore Details
Days Inn - Manning
+1-888-690-5247
2825 Paxville Highway, Manning, SC 29102 ~20.47 miles northeast of Santee
  • 2 star property
Southern Lodge : 3616 St. Matthews Rd. 3616 St. Matthews Rd., Orangeburg, SC 29118 ~20.48 miles west of Santee
  • Economy Highway hotel
  • Hotel has a green policy See policy
  • Rooms are not good
  • About half of guests said rooms were dirty
Travelodge Orangeburg 3620 St. Matthews Rd., Orangeburg, SC 29118 ~20.48 miles west of Santee
  • Economical Highway property
  • Check-in time: 12:00 PM
From$50
Average 3.5 /5Reviews CallBookMore Details
Sleep Inn Orangeburg 3689 Saint Matthews Rd., Orangeburg, SC 29118 ~20.49 miles west of Santee
  • Cheap Suburban hotel
  • Free complimentary breakfast
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