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Santee South Carolina Accommodations

Find the perfect hotel in Santee using our hotel guide provided below. Search for the cheapest discounted hotel and motel rates in or near Santee, SC for your upcoming personal or group trip. Discover the most favored Santee South Carolina hotel/motel rooms. Review the Santee hotel list below to find the perfect lodging. We also have a map of the Santee hotels. Coordinating a group? Get Santee Group Hotel Discounts

The Santee center point is around 2 miles west of Lake Marion Resort and Marina and 18 miles east of Edisto Memorial Gardens.

Santee Hotels & Accommodations

Days Inn 9074 Old Highway Six, Santee, SC 29142
  • 2 star hotel
Holiday Inn Santee : 139 Bradford Blvd. 139 Bradford Blvd., Santee, SC 29142
  • 3-star Highway property
  • 4 floors in hotel
From$125
Average 3.5 /5Reviews CallBookMore Details
Comfort Inn & Suites : 221 Britain St. 221 Britain St., Santee, SC 29142
  • Two-star Lake property
  • 61 sleeping rooms in hotel
  • Copious breakfast
  • Bathroom drained slowly
Quality Inn & Suites
+1-888-283-3404
8929 Old Number Six Highway, Santee, SC 29142
  • 2-star Highway hotel
  • Check-in time: 3:00PM
Red Roof Inn in Santee 9091 Old No 6 Highway, Santee, SC 29142
  • Cheap Golf Course hotel
  • 40 sleeping rooms in hotel
Howard Johnson : 249 Britain St. 249 Britain St., Santee, SC 29142
  • Economy Golf Course property
  • 60 rooms in property
Whitten Inn
+1-888-690-5281
123 Mall St., Santee, SC 29142
  • Cheap Highway hotel
  • 117 rooms in property
Hampton Inn Santee I 95 9060 Old #6 Highway, Santee, SC 29142
  • Affordable Highway property
  • 81 sleeping rooms in hotel
  • Great menu
  • Close to highway
From$106
Very Good 4.5 /5Read Reviews CallBookMore Details
Best Western Plus Santee Inn I 95 Exit 98, Santee, SC 29142
  • 3-star hotel
  • Free breakfast
From$80
Very Good 4.5 /5Review Score CallBookMore Details
Econo Lodge 9112 Old Number 6 Highway, Santee, SC 29142
  • 2-star Highway property
  • Free breakfast available
Rodeway Inn 9117 Old Number 6 Highway, Santee, SC 29142
  • Economical Highway property
  • Check in: 11:00
Days Inn Summerton 400 Buff Blvd., Summerton, SC 29148 ~10.34 miles northeast of Santee
  • Two-star hotel
  • Check in: 11:00 AM
Days Inn Orangeburg South 3402 Five Chop Rd., Orangeburg, SC 29115 ~14.02 miles west of Santee
  • Economical Highway hotel
  • Check in time: 2pm
Peachtree Inn - Saint George 111 Conners Dr., Saint George, SC 29477 ~15.51 miles south of Santee
  • Midscale Highway hotel
  • Check-in: 3.00
From$49
Very Good 4.0 /5Read Reviews CallBookMore Details
Sunset Inn Manning in Manning
+1-888-690-5247
5932 Alex Highway, Manning, SC 29102 ~16.27 miles northeast of Santee
  • Two star hotel
From$50
Not Good 1.5 /5Reviews CallBookMore Details
Hampton Inn : 2822 Paxville Highway 2822 Paxville Highway, Manning, SC 29102 ~19.30 miles northeast of Santee
  • Midscale Highway hotel
  • 73 rooms in hotel
From$90
Very Good 4.5 /5Read Reviews CallBookMore Details
Quality Inn 3031 Paxville Highway, Manning, SC 29102 ~19.32 miles northeast of Santee
  • 2 star Golf Course property
  • Check in time: 2:00 pm
  • Room needs to be redecorated
  • Poor, uncomfortable rooms
Fairfield Inn Orangeburg in Orangeburg 663 Citadel Rd., Orangeburg, SC 29118 ~20.26 miles west of Santee
  • Affordable Highway property
  • Complimentary breakfast is offered
  • Most guests said the beds were comfortable
  • Popular among business travelers
From$94
Very Good 4.0 /5Read Reviews CallBookMore Details
Country Inn & Suites Orangeburg - Orangeburg 731 Citadel Rd., Orangeburg, SC 29118 ~20.37 miles west of Santee
  • Economy property
  • 28 suites in property
Comfort Inn & Suites 746 Citadel Rd., Orangeburg, SC 29118 ~20.37 miles west of Santee
  • 2-star Rural hotel
  • Check in: 3 pm
  • Bathroom is ok
  • Generally very clean
Hampton Inn & Suites Orangeburg 749 Citadel Rd., Orangeburg, SC 29118 ~20.42 miles west of Santee
  • Mid-scale Highway hotel
  • Check in time: 3:00pm
From$124
Very Good 4.5 /5Latest Reviews CallBookMore Details
Days Inn : 2825 Paxville Highway
+1-888-690-5247
2825 Paxville Highway, Manning, SC 29102 ~20.47 miles northeast of Santee
  • Economy hotel
Southern Lodge in Orangeburg 3616 St. Matthews Rd., Orangeburg, SC 29118 ~20.48 miles west of Santee
  • Cheap Highway hotel
  • Check in time: 2.00pm
  • Average beds
  • Most guests said the bathroom was dirty
Travelodge Orangeburg in Orangeburg 3620 St. Matthews Rd., Orangeburg, SC 29118 ~20.48 miles west of Santee
  • Cheap Highway property
  • Hotel has 44 rooms
From$50
Average 3.5 /5Reviews CallBookMore Details
Sleep Inn Orangeburg - Orangeburg 3689 Saint Matthews Rd., Orangeburg, SC 29118 ~20.49 miles west of Santee
  • Low priced Suburban hotel
  • Hotel has 69 rooms
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