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Santee South Carolina Accommodations

Find the perfect hotel in Santee using our hotel guide provided below. Search for the cheapest discounted hotel and motel rates in or near Santee, SC for your upcoming personal or group trip. Discover the most favored Santee South Carolina hotel/motel rooms. Review the Santee hotel list below to find the perfect lodging. We also have a map of the Santee hotels. Coordinating a group? Get Santee Group Hotel Discounts

The Santee center point is around 2 miles west of Lake Marion Resort and Marina and 18 miles east of Edisto Memorial Gardens.

Santee Hotels, Motels & Accommodations

Days Inn 9074 Old Highway Six, Santee, SC 29142
  • Two-star property
Holiday Inn Santee - Santee 139 Bradford Blvd., Santee, SC 29142
  • Midscale Highway hotel
  • Hotel has an eco-friendly policy Read more
From$99
Average 3.5 /5 Guest Reviews Call
Comfort Inn & Suites - Santee 221 Britain St., Santee, SC 29142
  • Two star Lake hotel
  • 20 suites in hotel
From$115
Average 3.5 /5 Hotel Reviews Call
Quality Inn & Suites in Santee
+1-888-690-5247
8929 Old Number Six Highway, Santee, SC 29142
  • Low priced Highway hotel
  • Free breakfast available
From$72
Poor 2.5 /5 Reviews Call
Red Roof Inn 9091 Old No 6 Highway, Santee, SC 29142
  • Economical Golf Course hotel
  • Check-in: 1.00
From$52
Average 3.5 /5 Reviews Call
Howard Johnson Santee - Santee 249 Britain St., Santee, SC 29142
  • Cheap Golf Course property
  • Hotel has 60 rooms
From$40
Average 3.0 /5 Review Score Call
Whitten Inn - Santee
+1-800-997-5149
123 Mall St., Santee, SC 29142
  • Low priced Highway property
  • 3 meeting rooms in hotel
Hampton Inn Santee I 95
+1-888-690-5281
9060 Old #6 Highway, Santee, SC 29142
  • 3-star Highway hotel
  • Check in time: 3:00 pm
From$89
Very Good 4.5 /5 Reviews Call
Rodeway Inn Santee in Santee
+1-800-230-4134
9117 Old Number 6 Highway, Santee, SC 29142
  • Low Cost Highway hotel
  • Free complimentary breakfast
From$29
Average 3.0 /5 Reviews Call
Best Western Plus Santee Inn : 9059 Old Number Six Highway
+1-800-997-5148
9059 Old Number Six Highway, Santee, SC 29142
  • Three Star property
From$88
Very Good 4.5 /5 Latest Reviews Call
Econo Lodge in Santee
+1-888-690-5247
9112 Old Number 6 Hww., Santee, SC 29142
  • Inexpensive Highway property
  • 37 rooms in hotel
From$75
Average 3.0 /5 Latest Reviews Call
Peachtree Inn
+1-888-305-3366
111 Conners Dr., Saint George, SC 29477 ~15.51 miles south of Santee
  • Three Star Highway hotel
  • 39 rooms in hotel
From$49
Very Good 4.0 /5 Hotel Reviews Call
Sunset Inn Manning
+1-800-881-1523
5932 Alex Highway, Manning, SC 29102 ~16.27 miles northeast of Santee
  • Economy hotel
From$50
Terrible 1.5 /5 Guest Reviews Call
Hampton Inn - Manning 2822 Paxville Highway, Manning, SC 29102 ~19.30 miles northeast of Santee
  • Affordable Highway hotel
  • Check-in time: 2:00pm
From$90
Very Good 4.5 /5 Hotel Reviews Call
Quality Inn 3031 Paxville Highway, Manning, SC 29102 ~19.32 miles northeast of Santee
  • Inexpensive property
From$63
Average 3.5 /5 Guest Reviews Call
Country Inn & Suites in Orangeburg
+1-800-230-4134
731 Citadel Rd., Orangeburg, SC 29118 ~19.66 miles west of Santee
  • Economical hotel
  • Check in: 3:00 pm
From$94
Average 3.5 /5 Review Score Call
Fairfield Inn Orangeburg : 663 Citadel Rd. 663 Citadel Rd., Orangeburg, SC 29118 ~20.26 miles west of Santee
  • Three Star Highway property
  • Access to gym on-site
From$89
Average 3.5 /5 Recent Reviews Call
Comfort Inn & Suites : 746 Citadel Rd. 746 Citadel Rd., Orangeburg, SC 29118 ~20.37 miles west of Santee
  • Economy Rural hotel
  • 3 floors in hotel
From$90
Very Good 4.0 /5 Latest Reviews Call
Hampton Inn & Suites Orangeburg 749 Citadel Rd., Orangeburg, SC 29118 ~20.42 miles west of Santee
  • 3-star Highway hotel
  • 32 suites in property
From$119
Very Good 4.5 /5 Review Score Call
Days Inn in Manning
+1-800-881-1523
2825 Paxville Highway, Manning, SC 29102 ~20.47 miles northeast of Santee
  • 2-star property
Southern Lodge : 3616 St. Matthews Rd. 3616 St. Matthews Rd., Orangeburg, SC 29118 ~20.48 miles west of Santee
  • Low priced Highway property
  • Hotel has an eco-friendly policy See policy
From$44
Very Good 4.0 /5 Reviews Call
Sleep Inn Orangeburg 3689 Saint Matthews Rd., Orangeburg, SC 29118 ~20.49 miles west of Santee
  • Economical Suburban hotel
  • Check in: 2:00 PM
From$94
Average 3.5 /5 Hotel Reviews Call
Quality Inn & Suites in Orangeburg 3671 St. Matthews, Orangeburg, SC 29118 ~20.51 miles west of Santee
  • Cheap Rural property
  • 91 rooms in hotel
Holiday Inn Express & Suites of Orangeburg in Orangeburg 118 Sleep Inn Rd., Orangeburg, SC 29118 ~20.51 miles west of Santee
  • 3-star Rural hotel
  • Check-in: 1500
From$93
Very Good 4.0 /5 Reviews Call
Howard Johnson
+1-888-690-5247
3608 St. Matthews Rd., Orangeburg, SC 29118 ~20.53 miles west of Santee
  • Economical property
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