Santee South Carolina Accommodations

Find the perfect hotel in Santee using our hotel guide provided below. Search for the cheapest discounted hotel and motel rates in or near Santee, SC for your upcoming personal or group trip. Discover the most favored Santee South Carolina hotel/motel rooms. Review the Santee hotel list below to find the perfect lodging. We also have a map of the Santee hotels. Coordinating a group? Get Santee Group Hotel Discounts

The Santee center point is around 2 miles from Lake Marion Resort and Marina and 18 miles from Edisto Memorial Gardens.

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Santee Hotels/Accommodations

Days Inn
+1-800-230-4134Check Rates
9074 Old Highway Six, Santee, SC 29142
  • Low priced hotel
Image of Holiday Inn Santee Holiday Inn Santee
+1-800-997-5148Check Rates
139 Bradford Blvd., Santee, SC 29142
  • 3.0/5, Average Review Score
  • Affordable Highway hotel
  • 84 sleeping rooms in hotel
Exterior of Comfort Inn & Suites Comfort Inn & Suites - Santee
+1-800-997-5149Check Rates
221 Britain St., Santee, SC 29142
  • 4.0/5, Very Good Hotel Reviews
  • Two-star Lake property
  • Free complimentary breakfast
Image of Quality Inn & Suites Quality Inn & Suites : 8929 Old Number Six Highway
+1-800-230-4134Check Rates
8929 Old Number Six Highway, Santee, SC 29142
  • 3.0/5, Average Read Reviews
  • Low-priced Highway property
  • 153 rooms in property
Exterior of Howard Johnson Santee Howard Johnson Santee - Santee
+1-800-997-5148Check Rates
249 Britain St., Santee, SC 29142
  • 3.0/5, Average Latest Reviews
  • Economical Golf Course hotel
  • Hotel has 60 rooms
Image of Whitten Inn Whitten Inn in Santee
+1-800-997-5149Check Rates
123 Mall St., Santee, SC 29142
  • 2.5/5, Poor Reviews
  • Economy Highway property
  • Hotel has 2 floors
Hampton Inn Santee I 95
+1-800-230-4134Check Rates
9060 Old #6 Highway, Santee, SC 29142
  • 4.5/5, Very Good Recent Reviews
  • Mid-scale Highway property
  • Hotel has 81 rooms
Best Western Plus Santee Inn
+1-800-997-5148Check Rates
9059 Old Number Six Highway, Santee, SC 29142
  • Mid-scale property
Rodeway Inn Santee in Santee
+1-800-997-5149Check Rates
9117 Old Number 6 Highway, Santee, SC 29142
  • 3.0/5, Average Guest Reviews
  • Economical Highway hotel
  • Comp. Breakfast
Travelodge in Santee
+1-800-230-4134Check Rates
9091 Old Highway 6, Santee, SC 29142
  • 2.5/5, Poor Guest Reviews
  • Low Cost Golf Course hotel
  • Check in: 1.00
Econo Lodge
+1-800-997-5148Check Rates
9112 Old Number 6 Hww., Santee, SC 29142
  • Cheap Highway hotel
  • Free comp. breakfast
Peachtree Inn - Saint George
+1-800-997-5149Check Rates
111 Conners Dr., Saint George, SC 29477
  • 4.5/5, Very Good Recent Reviews
  • Midscale Highway hotel
  • 2 floors in property
~15.51 Miles from Santee
Sunset Inn Manning : 5932 Alex Highway
+1-800-230-4134Check Rates
5932 Alex Highway, Manning, SC 29102 ~16.27 Miles from Santee
Hampton Inn
+1-800-997-5148Check Rates
2822 Paxville Highway, Manning, SC 29102
  • 4.5/5, Very Good Hotel Reviews
  • Three Star Highway hotel
  • Free comp. breakfast
~19.30 Miles from Santee
Quality Inn : 3031 Paxville Highway
+1-800-997-5149Check Rates
3031 Paxville Highway, Manning, SC 29102 ~19.32 Miles from Santee
Country Inn & Suites
+1-800-230-4134Check Rates
731 Citadel Rd., Orangeburg, SC 29118
  • 3.5/5, Average Hotel Reviews
  • Economy property
  • 81 rooms in hotel
~19.66 Miles from Santee
Fairfield Inn Orangeburg
+1-800-997-5148Check Rates
663 Citadel, Orangeburg, SC 29118
  • 3.5/5, Average Review Score
  • 3 star hotel
  • 60 rooms in hotel
~20.28 Miles from Santee
Comfort Inn & Suites in Orangeburg
+1-800-997-5149Check Rates
746 Citadel Rd., Orangeburg, SC 29118
  • 4.0/5, Very Good Reviews
  • Inexpensive Rural hotel
  • Free complimentary breakfast
~20.37 Miles from Santee
Days Inn : 2825 Paxville Highway
+1-800-230-4134Check Rates
2825 Paxville Highway, Manning, SC 29102 ~20.47 Miles from Santee
Image of Southern Lodge Southern Lodge
+1-800-997-5148Check Rates
3616 St. Matthews Rd., Orangeburg, SC 29118 Website
  • Cheap Highway hotel
  • 43 rooms in property
~20.48 Miles from Santee

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