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Cairo Illinois Accommodations

Find hotels & motels in Cairo using the list below. Search for cheap and discounted hotel and motel rates in or close to Cairo, IL for your upcoming individual or group travel. Discover the best Cairo Illinois hotel/motel rooms. Review the Cairo hotel list below to find the perfect lodging. We also have a map of the Cairo hotels.

Cairo Hotels/Accommodations

Quality Inn Cairo I-57 13201 Kessler Rd., Cairo, IL 62914
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  • Three Star Highway hotel
  • Check in time: 3 pm
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From$60
Poor 2.0 /5 Review Score Call BookMore Details
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Super 8 by Wyndham Charleston/Sikeston East MO : 310 South Story 310 South Story, Charleston, MO 63834
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~10.13 miles southwest of Cairo
  • Low priced Highway hotel
  • 60 rooms in property
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From$42
Average 3.5 /5 Read Reviews Call BookMore Details
The Riverstone Hotel Charleston-Sikeston - Charleston 102 Drake St., Charleston, MO 63834
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~11.88 miles southwest of Cairo
  • Low Cost Highway property
  • Hotel has 2 floors
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From$59
Average 3.0 /5 Review Score Call BookMore Details
Americas Best Value Inn Ullin Mounds 128 Cheekwood Lane, Ullin, IL 62992
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~17.88 miles north of Cairo
  • Cheap property
  • 40 rooms in property
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From$60
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Motel 6 Sikeston Mo 110 South Interstate Dr., SIKESTON, MO 63801
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~20.96 miles west of Cairo
  • 2 star hotel
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From$60
Average 3.0 /5 Latest Reviews Call BookMore Details
Best Western Plus Sikeston I-55 - Sikeston 120 South Interstate Dr., Sikeston, MO 63801
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~21.00 miles west of Cairo
  • 2 star Highway hotel
  • Free comp. breakfast
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From$43
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Days Inn & Suites by Wyndham Sikeston - Sikeston 220 South Interstate Dr., Sikeston, MO 63801
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~21.07 miles west of Cairo
  • 2-star property
  • Check-in time: 03:00 PM
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From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) 100 Matthews Lane, Sikeston, MO 63801
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~21.31 miles west of Cairo
  • 3-star Highway property
  • Check in: 3:00 PM
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From$80
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Super 8 by Wyndham Sikeston/Miner Area 2609 East Malone, Sikeston, MO 63801
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~21.32 miles west of Cairo
  • Economy Convention Center property
  • Check-in time: 01:00
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From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
Comfort Inn 109 Matthews Lane, Sikeston, MO 63801
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~21.34 miles west of Cairo
  • 3 star Highway property
  • 64 sleeping rooms in hotel
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From$85
Average 3.0 /5 Latest Reviews Call BookMore Details
Drury Inn & Suites Sikeston 2608 East Malone Ave., Sikeston, MO 63801
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~21.37 miles west of Cairo
  • 3 star Highway hotel
  • 5 floors in hotel
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From$104
Very Good 4.5 /5 Review Score Call BookMore Details
Pear Tree Inn Sikeston - Sikeston 2602 East Malone, Sikeston, MO 63801
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~21.38 miles west of Cairo
  • Midscale Suburban hotel
  • 4 floors in property
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From$80
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Hampton Inn Sikeston 1240 Commerce Dr., Sikeston, MO 63801
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~24.48 miles west of Cairo
  • 3 star Rural hotel
  • Hotel has 8 suites
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From$80
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Holiday Inn Express & Suites Sikeston An Ihg Hotel - Sikeston 115 Hospitality Dr., Sikeston, MO 63801
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~24.49 miles west of Cairo
  • Mid-scale Rural property
  • Free comp. breakfast
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From$80
Average 3.0 /5 Guest Reviews Call BookMore Details
Residence Inn by Marriott Paducah : 3900 Coleman Crossing Circle 3900 Coleman Crossing Circle, Paducah, KY 42001
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~25.66 miles east of Cairo
  • 3-star Suburban hotel
  • 74 suites in hotel
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From$89
Very Good 4.0 /5 Latest Reviews Call BookMore Details
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Pear Tree Inn Paducah - Paducah 5006 Hinkleville Rd., Paducah, KY 42001
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~25.77 miles east of Cairo
  • Low-priced Suburban property
  • Free comp. breakfast
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From$55
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destinatio 100 East Front St., Metropolis, IL 62960
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~26.28 miles east of Cairo
  • Four-star property
  • 7 floors in hotel
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From$160
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Baymont by Wyndham Metropolis 203 East Front St., Metropolis, IL 62960
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~26.32 miles east of Cairo
  • Cheap Riverfront property
  • Free breakfast available
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From$45
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Econo Lodge - Metropolis 1415 East 5th St., Metropolis, IL 62960
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~27.38 miles east of Cairo
  • Economy property
  • Check-in time: 11:00
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From$60
Not Good 1.0 /5 Read Reviews Call BookMore Details
 Econo Lodge Paducah West I-24 in Paducah 5120 Hinkleville Rd., Paducah, KY 42001
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~27.55 miles east of Cairo
  • Two star Airport property
  • 75 rooms in hotel
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From$60
Average 3.0 /5 Latest Reviews Call BookMore Details
Baymont by Wyndham Paducah 5300 Old Cairo Rd., Paducah, KY 42001
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~27.64 miles east of Cairo
  • Midscale property
  • Check-in time: 15:00
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From$40
Poor 2.0 /5 Read Reviews Call BookMore Details
Courtyard by Marriott Cape Girardeau Downtown 400 Broadway St., Cape Girardeau, MO 63701
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~27.65 miles northwest of Cairo
  • Affordable Downtown property
  • 13 suites in hotel
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From$80
Very Good 4.0 /5 Read Reviews Call BookMore Details
Drury Suites Paducah in Paducah 2930 James Sanders Blvd., Paducah, KY 42001
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~27.70 miles east of Cairo
  • Affordable Suburban property
  • 138 rooms in property
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From$99
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Quality Suites Paducah I-24 : 2880 James Sanders Blvd. 2880 James Sanders Blvd., Paducah, KY 42001 Website
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~27.73 miles east of Cairo
  • Low priced Highway property
  • 59 suites in property
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From$60
Average 3.0 /5 Hotel Reviews Call BookMore Details
Comfort Inn & Suites near Six Flags 960 West Pointe Court, Lithia Springs, GA 30122 Website
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~27.80 miles east of Cairo
  • 3 star Downtown property
  • 60 rooms in property
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From$70
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Garner Hotel Paducah West by IHG 145 Mcbride Lane, Paducah, KY 42001
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~27.80 miles east of Cairo
  • Mid-scale Highway property
  • Fitness / Gym is on-site
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From$49
Very Good 4.0 /5 Review Score Call BookMore Details
Hotel 7 Inn Paducah in Paducah 5001 Hinkleville Rd., Paducah, KY 42001
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~27.81 miles east of Cairo
  • Inexpensive hotel
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From$60
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La Quinta Inn & Suites by Wyndham Paducah - Paducah 3960 Coleman Crossing Cir, Paducah, KY 42001
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~27.90 miles east of Cairo
  • Mid-scale Highway property
  • 26 suites in hotel
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From$80
Average 3.0 /5 Reviews Call BookMore Details
Candlewood Suites Paducah by IHG - Paducah 3940 Coleman Crossing Circle, Paducah, KY 42001
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~27.91 miles east of Cairo
  • 3 star Rural property
  • 85 suites in property
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From$60
Very Good 4.0 /5 Read Reviews Call BookMore Details
Homewood Suites by Hilton Paducah in Paducah 3925 Coleman Crossing Cir, Paducah, KY 42001
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~27.94 miles east of Cairo
  • Mid-scale Highway property
  • 97 rooms in property
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From$109
Very Good 4.0 /5 Review Score Call BookMore Details
Comfort Suites 3918 Coleman Crossing Cir Paducah Ky 42001, Paducah, KY 42001
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~27.96 miles east of Cairo
  • Low priced Rural hotel
  • Check-in: 3:00pm
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From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
Comfort Inn Paducah in Paducah 5135 Cairo Rd., Paducah, KY 42001
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~27.98 miles east of Cairo
  • Mid-scale hotel
  • Access to gym on-site
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From$59
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Fairfield Inn & Suites by Marriott Paducah in Paducah 3950 Coleman Crossing Circle, Paducah, KY 42001
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~28.01 miles east of Cairo
  • 3-star Rural hotel
  • Check in: 3:00 pm
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From$75
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Red Roof Inn Paducah 5106 Old Cairo Rd., Paducah, KY 42001
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~28.01 miles east of Cairo
  • Inexpensive property
  • 3 floors in property
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From$45
Average 3.5 /5 Review Score Call BookMore Details
American Inn in Paducah 5125 Cairo Rd., Paducah, KY 42001
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~28.02 miles east of Cairo
  • 2 star property
  • Free breakfast
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From$37
Very Good 4.0 /5 Review Score Call BookMore Details
Hampton Inn & Suites Paducah 3901 Coleman Crossing Circle, Paducah, KY 42001
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~28.02 miles east of Cairo
  • 3 star Highway hotel
  • Check in: 3:00 pm
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From$79
Very Good 4.5 /5 Reviews Call BookMore Details
Holiday Inn Express Hotel & Suites Paducah West by IHG 3996 Hinkleville Rd., Paducah, KY 42001
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~28.04 miles east of Cairo
  • Midscale Highway hotel
  • Check-in time: 3:00 PM
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From$80
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Auburn Place Hotel & Suites - Paducah 3994 Hinkleville Rd., Paducah, KY 42001
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~28.05 miles east of Cairo
  • 3-star Airport hotel
  • Gym / Fitness Center Available
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From$80
Very Good 4.0 /5 Reviews Call BookMore Details
Courtyard by Marriott Paducah 3835 Technology Dr., Paducah, KY 42001
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~28.29 miles east of Cairo
  • Midscale Suburban property
  • 3 floors in hotel
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From$89
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Drury Inn Paducah in Paducah 3975 Hinkleville Rd., Paducah, KY 42001
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~28.70 miles east of Cairo
  • Mid-scale Suburban hotel
  • 5 meeting rooms in property
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From$79
Very Good 4.5 /5 Hotel Reviews Call BookMore Details
Days Inn by Wyndham Paducah I-24 Exit 4 3901 Hinkleville Rd., Paducah, KY 42001
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~28.75 miles east of Cairo
  • Low priced Highway property
  • 32 suites in property
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From$50
Average 3.0 /5 Recent Reviews Call BookMore Details
Candlewood Suites Cape Girardeau by IHG - Cape Girardeau 485 South Mount Auburn Rd., Cape Girardeau, MO 65703
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~28.76 miles northwest of Cairo
  • Cheap Highway property
  • Hotel has 85 suites
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From$69
Very Good 4.0 /5 Read Reviews Call BookMore Details
Travelers Inn and Suites 2550 Lone Oak Rd., Paducah, KY 42003
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~28.88 miles east of Cairo
  • Cheap hotel
  • Hotel has 30 suites
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From$38
Very Good 4.0 /5 Read Reviews Call BookMore Details
Quality Inn & Suites Metropolis I-24 : 2118 East 5th St. 2118 East 5th St., Metropolis, IL 62960
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~28.88 miles east of Cairo
  • 3-star property
  • Check-in: 11:00
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From$80
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Super 8 by Wyndham Metropolis 2055 East 5th St., Metropolis, IL 62960
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~28.89 miles east of Cairo
  • Two-star Highway property
  • Hotel has 2 floors
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From$60
Average 3.0 /5 Hotel Reviews Call BookMore Details
Motel 6 Metropolis Il in Metropolis 2119 East 5th St., Metropolis, IL 62960
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~29.04 miles east of Cairo
  • Economy property
  • Check in: 11:00 AM
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From$60
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Holiday Inn Express Metropolis by IHG : 2179 East 5th St. 2179 East 5th St., Metropolis, IL 62960
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~29.10 miles east of Cairo
  • Mid-scale Rural hotel
  • 3 floors in property
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From$65
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Hampton Inn Cape Girardeau I 55 East 207 South Mount Auburn Rd., Cape Girardeau, MO 63703
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~29.41 miles northwest of Cairo
  • 3-star Highway property
  • Free comp. breakfast
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From$80
Excellent 5.0 /5 Review Score Call BookMore Details
Victorian Inn & Suites 3256 William St., Cape Girardeau, MO 63703
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~29.41 miles northwest of Cairo
  • 3 star Golf Course property
  • Check-in: 3:00 pm
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From$79
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Auburn Place Hotel & Suites 3265 Williams St., Cape Girardeau, MO 63702
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~29.42 miles northwest of Cairo
  • Affordable Highway hotel
  • 2 floors in property
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From$58
Very Good 4.5 /5 Review Score Call BookMore Details

Next: See My Cairo Hotels with Pricing

Graph: Upcoming 20 Days of Cairo Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Cairo, IL discounts available. The chart reflects the cheapest Cairo hotel for each day and each star rating category.

FAQs about hotels in Cairo

What are the most favored hotels in Cairo?

Hampton Inn Cape Girardeau I 55 East, Drury Inn & Suites Sikeston and Hampton Inn & Suites Paducah are the best rated hotels based on customer reviews in the last 365 days.

What are the most luxurious hotels in Cairo?

Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destinatio, Quality Inn Cairo I-57 and Travel Inn & Suites - Sikeston are the top 3 luxury hotels near Cairo city center.

What hotels are closest to the city center of Cairo?

Quality Inn Cairo I-57, Super 8 by Wyndham Charleston, and The Riverstone Hotel Charleston-Sikeston are the properties closest to Cairo city center.

What are the best independent hotels in Cairo?

Auburn Place Hotel & Suites, Travel Inn & Suites - Sikeston and Drury Suites Paducah are the best rated independent hotels (not part of a big brand).

What are the most popular Marriott hotels in Cairo?

Residence Inn by Marriott Paducah, Courtyard by Marriott Cape Girardeau Downtown and Fairfield Inn & Suites by Marriott Paducah are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the best Choice Hotels branded hotels in Cairo?

Comfort Inn & Suites near Six Flags, Comfort Inn Paducah and Quality Inn & Suites Metropolis I-24 are the best rated Choice Hotels branded hotels (based on HotelPlanner reviews score).

What are the most popular IHG hotels in Cairo?

Candlewood Suites Paducah by IHG, Candlewood Suites Cape Girardeau by IHG and Holiday Inn Express Metropolis by IHG are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

Verified reviews of the city: Cairo, IL

Below are reviews of the city of Cairo, IL from an actual visitor's perspective.

"Spending time with my family"
Score 5.0 / 5

Vincent R., from 26-Jan-2026
The average traveler rating of the city of Cairo, IL shown above is 5.0 out of 5 based on 1 reviews
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