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Charleston Missouri Hotels & Motels

Find the perfect hotel in Charleston using our hotel guide provided below. Find discounted hotel accommodations in or close to Charleston, MO for your upcoming individual or group travel. Discover the most popular Charleston, Missouri hotel and motel rooms. Browse the Charleston area hotels to find the perfect lodging! Please use the provided map of the Charleston hotels. Coordinating a group? Get Charleston Group Hotel Rates

Charleston Hotels, Motels & Accommodations

Super 8 in Charleston
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
310 South Story, Charleston, MO 63834
  • 2-star Highway hotel
  • 60 sleeping rooms in hotel
More PhotosPhoto of Super 8
From$42
Average 3.5 /5Recent Reviews CallBookMore Details
Quality Inn - Charleston
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
102 Drake St., Charleston, MO 63834
  • Economical Highway hotel
  • 40 rooms in property
More PhotosImage of Quality Inn
From$59
Average 3.5 /5Reviews CallBookMore Details
Motel 6 Sikeston Mo #4328
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
110 South Interstate Dr., SIKESTON, MISSOURI 63801 ~11.02 miles west of Charleston
  • Economy hotel
More Photoshotel room
From$60
Average 3.0 /5Review Score CallBookMore Details
Best Western Plus Sikeston in Sikeston
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
120 South Interstate Dr., Sikeston, MO 63801 ~11.05 miles west of Charleston
  • Two-star Highway hotel
  • 2 floors in hotel
More PhotosExterior of Best Western Plus Sikeston
From$60
Very Good 4.5 /5Hotel Reviews CallBookMore Details
Days Inn & Suites by Wyndham Sikeston - Sikeston
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
220 South Interstate Dr., Sikeston, MO 63801 ~11.09 miles west of Charleston
  • Two-star hotel
  • Gym / Fitness Center Available
More Photoshotel room
From$60
Average 3.0 /5Read Reviews CallBookMore Details
Quality Inn - Cairo
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
13201 Kessler Rd., Cairo, IL 62914 ~11.20 miles northeast of Charleston
  • Midscale Highway hotel
  • Hotel has 38 rooms
  • Average amenities
  • World class service
More PhotosExterior of Quality Inn
From$60
Average 3.5 /5Recent Reviews CallBookMore Details
Super 8 by Wyndham Sikeston / Miner Area - Sikeston
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
2609 East Malone, Sikeston, MO 63801 ~11.36 miles west of Charleston
  • Cheap Convention Center hotel
  • Free breakfast available
More PhotosImage of Super 8 by Wyndham Sikeston / Miner Area
From$60
Average 3.0 /5Recent Reviews CallBookMore Details
Country Hearth Inn & Suites Sikeston
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
100 Matthews Lane, Sikeston, MO 63801 ~11.37 miles west of Charleston
  • Midscale Highway property
  • 2 floors in hotel
  • Average comfort
  • Air conditioner took forever
More PhotosExterior of Country Hearth Inn & Suites Sikeston
From$80
Very Good 4.5 /5Guest Reviews CallBookMore Details
Comfort Inn
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
109 Matthews Lane, Sikeston, MO 63801 ~11.40 miles west of Charleston
  • Affordable Highway property
  • Access to gym on-site
More PhotosPhoto of Comfort Inn
From$85
Average 3.0 /5Latest Reviews CallBookMore Details
Drury Inn & Suites Sikeston
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
2608 East Malone Ave., Sikeston, MO 63801 ~11.45 miles west of Charleston
  • 3-star Highway hotel
  • Fitness center on property
  • Most guests loved the menu selection
  • Easily accessible by car
More PhotosImage of Drury Inn & Suites Sikeston
From$104
Very Good 4.5 /5Read Reviews CallBookMore Details
Pear Tree Inn Sikeston - Sikeston
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
2602 East Malone, Sikeston, MO 63801 ~11.45 miles west of Charleston
  • Mid-scale Suburban property
  • Hotel has 4 floors
  • Staff was very helpful and accommodating
  • Great reception
More PhotosPhoto of Pear Tree Inn Sikeston
From$80
Average 3.0 /5Hotel Reviews CallBookMore Details
Holiday Inn Express Sikeston
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
115 Hospitality Dr., Sikeston, MO 63801 ~14.33 miles west of Charleston
  • 3-star hotel
  • 73 rooms in property
More PhotosExterior of Holiday Inn Express Sikeston
From$94
Very Good 4.0 /5Recent Reviews CallBookMore Details
Hampton Inn Sikeston Mo in Sikeston
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
1240 Commerce Dr., Sikeston, MO 63801 ~14.72 miles west of Charleston
  • 3-star hotel
  • Gym is available on property
More PhotosImage of Hampton Inn Sikeston Mo
From$90
Very Good 4.5 /5Reviews CallBookMore Details
Americas Best Value Inn
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
128 Cheekwood Lane, Ullin, IL 62992 ~25.98 miles north of Charleston
  • 2-star hotel
  • 2 floors in hotel
More PhotosPhoto of Americas Best Value Inn
From$60
Very Good 4.0 /5Guest Reviews CallBookMore Details
Courtyard Cape Girardeau Downtown
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
400 Broadway St., Cape Girardeau, MO 63701 ~28.56 miles north of Charleston
  • 3 star Downtown property
  • 78 rooms in hotel
More PhotosPhoto of Courtyard Cape Girardeau Downtown
From$80
Very Good 4.5 /5Read Reviews CallBookMore Details
Candlewood Suites Cape Girardeau : 485 South Mount Auburn Rd.
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
485 South Mount Auburn Rd., Cape Girardeau, MO 65703 ~28.61 miles northwest of Charleston
  • Low-priced Highway property
  • Hotel has 85 rooms
More PhotosExterior of Candlewood Suites Cape Girardeau
From$69
Very Good 4.0 /5Reviews CallBookMore Details
Hampton Inn Cape Girardeau I 55 East : 207 South Mt. Auburn Rd.
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
207 South Mt. Auburn Rd., Cape Girardeau, MO 63703 ~29.29 miles northwest of Charleston
  • Three Star property
  • Hotel has 4 floors
More PhotosPhoto of Hampton Inn Cape Girardeau I 55 East
From$69
Excellent 5.0 /5Recent Reviews CallBookMore Details
Auburn Place Hotel & Suites
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
3265 Williams St., Cape Girardeau, MO 63702 ~29.41 miles northwest of Charleston
  • 3-star Highway property
  • 133 rooms in property
  • Good fitness area
  • Room was clean
More PhotosImage of Auburn Place Hotel & Suites
From$58
Very Good 4.5 /5Reviews CallBookMore Details
Holiday Inn Express & Suites Cape Girardeau I 55
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
3253 William St., Cape Girardeau, MO 63701 ~29.43 miles northwest of Charleston
  • Two-star property
  • Fitness + Health Center
More PhotosImage of Holiday Inn Express & Suites Cape Girardeau I 55
From$60
Very Good 4.5 /5Review Score CallBookMore Details
Pear Tree Inn Cape Girardeau West
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
103 Cape West Pkwy., Cape Girardeau, MO 63701 ~29.49 miles northwest of Charleston
  • Cheap property
  • 3 floors in property
More PhotosPhoto of Pear Tree Inn Cape Girardeau West
From$60
Average 3.0 /5Latest Reviews CallBookMore Details
Pear Tree Inn Cape Girardeau Medical Center
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
3248 William St., Cape Girardeau, MO 63701 ~29.50 miles northwest of Charleston
  • Cheap Highway hotel
  • Free breakfast available
  • Most guests said the beds were comfortable
  • Hotel rooms are very small
More PhotosPhoto of Pear Tree Inn Cape Girardeau Medical Center
From$66
Average 3.0 /5Recent Reviews CallBookMore Details
Drury Suites Cape Girardeau in Cape Girardeau
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
3303 Campster Dr., Cape Girardeau, MO 63701 ~29.60 miles northwest of Charleston
  • 3 star Highway property
  • Fitness center on property
  • Breakfast was good for
  • Registration desk helped with
More PhotosExterior of Drury Suites Cape Girardeau
From$85
Very Good 4.5 /5Recent Reviews CallBookMore Details
Drury Plaza Hotel & Conference Center Cape Girardeau - Cape Girardeau
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
3351 Percy Dr., Cape Girardeau, MO 63701 ~29.79 miles northwest of Charleston
  • Mid-scale hotel
  • Complimentary breakfast is offered
More PhotosPhoto of Drury Plaza Hotel & Conference Center Cape Girardeau
From$80
Average 3.0 /5Latest Reviews CallBookMore Details
Travelodge : 301 Route Ad
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
301 Route Ad, Marston, MO 63866 ~31.28 miles southwest of Charleston
  • Economy Highway hotel
  • 60 rooms in hotel
More PhotosPhoto of Travelodge
From$40
Poor 2.5 /5Recent Reviews CallBookMore Details
Travelodge by Wyndham Marston
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
301 State Highway Ad, Martson, MO 63866 ~31.46 miles southwest of Charleston
  • Economy hotel
More PhotosImage of Travelodge by Wyndham Marston
From$60
Poor 2.5 /5Read Reviews CallBookMore Details
Next 25 Charleston Hotels >  [1 - 25 of 50]    
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Graph of Charleston, MO Hotel Prices for Next 20 Days

Rates shown are nightly rates before taxes and do not necessarily reflect all Charleston, MO discounts available. The chart reflects the cheapest Charleston hotel for each day and each star rating category.

FAQs about hotels in Charleston

What are the top reviewed hotels in Charleston?

Hampton Inn Cape Girardeau I 55 East, Homewood Suites by Hilton Paducah and Best Western Plus Sikeston are the best rated hotels based on customer reviews in the last 365 days.

What are the most luxurious hotels in Charleston?

Harrah's Metropolis Hotel & Casino, Quality Inn and Country Hearth Inn & Suites Sikeston are the top 3 luxury hotels near Charleston city center.

What hotels are closest to the city center of Charleston?

Super 8, Quality Inn, and Motel 6 Sikeston Mo #4328 are the properties closest to Charleston city center.

How much does a cheap hotel in Charleston cost per night?

In the last year, a 2 star hotel in Charleston can be as cheap as $69.99 per night. (based on HotelPlanner prices)

How much does a 3 star hotel in Charleston cost per night?

In the last year, the average 3 star hotel in Charleston has been $54.99 per night. (based on HotelPlanner prices)

What are the best independent hotels in Charleston?

Auburn Place Hotel & Suites, Drury Suites Cape Girardeau and Drury Suites Paducah are the best rated independent hotels (not part of a big brand).

What are the most popular Marriott hotels in Charleston?

Courtyard Cape Girardeau Downtown and Residence Inn are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the most popular Choice Hotels branded hotels in Charleston?

Sleep Inn Union City, Comfort Suites Jackson and Quality Suites are the best rated Choice Hotels branded hotels (based on HotelPlanner reviews score).

What are the most popular Best Western hotels in Charleston?

Best Western Plus Sikeston and Best Western Plus Jackson are the best rated Best Western branded hotels (based on user reviews score).

What are the best IHG hotels in Charleston?

Holiday Inn Express & Suites Cape Girardeau I 55, Holiday Inn Express Sikeston and Candlewood Suites Cape Girardeau are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

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