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Charleston Missouri Hotels & Motels

Find the perfect hotel in Charleston using our hotel guide provided below. Find discounted hotel accommodations in or close to Charleston, MO for your upcoming individual or group travel. Discover the most popular Charleston, Missouri hotel and motel rooms. Browse the Charleston area hotels to find the perfect lodging! Please use the provided map of the Charleston hotels. Coordinating a group? Get Charleston Group Hotel Rates

Charleston Hotels/Motels & Accommodations

Super 8 310 South Story, Charleston, MO 63834
  • Low priced Highway hotel
  • Free comp. breakfast
Quality Inn : 102 Drake St. 102 Drake St., Charleston, MO 63834
  • Low-priced Highway property
  • 9 suites in hotel
Best Western Plus Sikeston : 120 South Interstate Dr. 120 South Interstate Dr., Sikeston, MO 63801 ~11.05 miles west of Charleston
  • Inexpensive Highway hotel
  • Hotel has 55 rooms
From$75
Very Good 4.5 /5Review Score CallBookMore Details
Americas Best Value Inn & Suites : 220 South Interstate Dr. 220 South Interstate Dr., Sikeston, MO 63801 ~11.09 miles west of Charleston
  • Economy hotel
  • 60 suites in property
Quality Inn 13201 Kessler Rd., Cairo, IL 62914 ~11.20 miles northeast of Charleston
  • 3 star property
  • Check-in time: 11:00
Country Hearth Inn & Suites Sikeston 100 Matthews Lane, Sikeston, MO 63801 ~11.37 miles west of Charleston
  • Inexpensive Highway property
  • Hotel has 40 rooms
  • Good parking spaces
  • Bed was comfortable
Comfort Inn & Suites
+1-888-690-5281
109 Matthews Lane, Sikeston, MO 63801 ~11.37 miles west of Charleston
  • 3-star Highway property
  • Check in: 02:00 PM
  • Nice indoor pool and fitness room
  • Most guests said the reception staff was great
From$80
Average 3.5 /5Reviews CallBookMore Details
Drury Inn & Suites Sikeston 2608 East Malone Ave., Sikeston, MO 63801 ~11.45 miles west of Charleston
  • 3-star Highway hotel
  • Has environment-friendly policy See more
  • Clean
  • Great room
Super 8
+1-888-305-3366
2609 East Malone Ave., Sikeston, MO 63801 ~11.45 miles west of Charleston
  • Low Cost Convention Center hotel
  • 62 rooms in property
From$44
Average 3.0 /5Reviews CallBookMore Details
Pear Tree Inn Sikeston in Sikeston 2602 East Malone, Sikeston, MO 63801 ~11.45 miles west of Charleston
  • Affordable Suburban property
  • 4 floors in property
  • Most guests said the reception staff was great
  • Desk clerk was very friendly and courteous
Holiday Inn Express & Suites Sikeston : 115 Hospitality Dr. 115 Hospitality Dr., Sikeston, MO 63801 ~14.33 miles west of Charleston
  • Inexpensive property
  • Fitness / Gym is on-site
Days Inn Sikeston : 1330 South Main St.
+1-866-221-8581
1330 South Main St., Sikeston, MO 63801 ~14.44 miles west of Charleston
  • Economy hotel
  • Check-in: 11:00 AM
Americas Best Value Inn 128 Cheekwood Lane, Ullin, IL 62992 ~25.98 miles north of Charleston
  • Cheap property
Candlewood Suites Cape Girardeau - Cape Girardeau 485 South Mount Auburn Rd., Cape Girardeau, MO 65703 ~28.61 miles northwest of Charleston
  • 2 star Highway property
  • 4 floors in hotel
From$55
Very Good 4.0 /5Review Score CallBookMore Details
Victorian Inn & Suites in Cape Girardeau
+1-888-690-5247
3256 William St., Cape Girardeau, MO 63703 ~29.40 miles northwest of Charleston
  • 3 star Golf Course hotel
  • Hotel has 2 floors
Auburn Place Hotel & Suites in Cape Girardeau 3265 Williams St., Cape Girardeau, MO 63702 ~29.41 miles northwest of Charleston
  • 3-star Highway property
  • 5 suites in hotel
  • Giant hot tub
  • Room was clean
From$99
Very Good 4.0 /5Review Score CallBookMore Details
Holiday Inn Express & Suites Cape Girardeau I 55 : 3253 William St.
+1-800-881-1523
3253 William St., Cape Girardeau, MO 63701 ~29.43 miles northwest of Charleston
  • Low-priced property
  • Fitness + Health Center
From$60
Very Good 4.5 /5Read Reviews CallBookMore Details
Pear Tree Inn Cape Girardeau West 103 Cape West Pkwy., Cape Girardeau, MO 63701 ~29.49 miles northwest of Charleston
  • 2 star hotel
  • Free breakfast available
Pear Tree Inn Cape Girardeau Medical Center : 3248 William St. 3248 William St., Cape Girardeau, MO 63701 ~29.50 miles northwest of Charleston
  • Economical Highway property
  • Check-in time: 3:00 pm
  • Clean bed
  • Very quiet
Drury Suites Cape Girardeau in Cape Girardeau 3303 Campster Dr., Cape Girardeau, MO 63701 ~29.60 miles northwest of Charleston
  • Affordable Highway property
  • Gym / Fitness Center Available
  • Pool is below average
  • Decent food
From$99
Very Good 4.5 /5Review Score CallBookMore Details
Drury Lodge Cape Girardeau : 104 South Vantage Dr. 104 South Vantage Dr., Cape Girardeau, MO 63701 ~29.76 miles northwest of Charleston
  • Affordable Highway hotel
  • 8 meeting rooms in property
  • Most guests thought beverage prices were a great value
  • Right by the highway
Drury Plaza Hotel & Conference Center Cape Girardeau 3351 Percy Dr., Cape Girardeau, MO 63701 ~29.79 miles northwest of Charleston
  • Midscale hotel
Travelodge in Marston 301 Route Ad, Marston, MO 63866 ~31.28 miles southwest of Charleston
  • Inexpensive Highway property
  • Check-in time: 3:00 PM
Super 8 Cape Girardeau - Cape Girardeau 2011 North Kingshighway, Cape Girardeau, MO 63701 ~31.73 miles northwest of Charleston
  • Low Cost property
  • Check in time: 11:00 AM
Comfort Suites Jackson / Cape Girardeau 2904 Old Orchard Rd., Jackson, MO 63755 ~33.57 miles northwest of Charleston
  • 3-star Highway hotel
  • 64 suites in property
  • Most guests thought they were poorly maintained
  • Easily accessible by car, said 100%
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