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Charleston Missouri Hotels & Motels

Find the perfect hotel in Charleston using our hotel guide provided below. Find discounted hotel accommodations in or close to Charleston, MO for your upcoming individual or group travel. Discover the most popular Charleston, Missouri hotel and motel rooms. Browse the Charleston area hotels to find the perfect lodging! Please use the provided map of the Charleston hotels. Coordinating a group? Get Charleston Group Hotel Rates

Charleston Hotels/Motels & Accommodations

Super 8
+1-888-690-5247

How should we direct your call?

New Reservations: +1-888-690-5247 Group Sales: +1-888-494-8863 Front Desk: 15736832125
310 South Story, Charleston, MO 63834
  • Low-priced Highway property
  • Check in: 3:00pm
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From$49
Average 3.5 /5Read Reviews CallBookMore Details
Quality Inn in Charleston
+1-888-305-3366

How should we direct your call?

New Reservations: +1-888-305-3366 Group Sales: +1-888-494-8863 Front Desk: 15736834200
102 Drake St., Charleston, MO 63834
  • Low priced Highway hotel
  • Hotel has 9 suites
More Photos Photo of Quality Inn
From$67
Average 3.5 /5Latest Reviews CallBookMore Details
Best Western Plus Sikeston - Sikeston
+1-800-881-1523

How should we direct your call?

New Reservations: +1-800-881-1523 Group Sales: +1-888-494-8863 Front Desk: 15734819500
120 South Interstate Dr., Sikeston, MO 63801 ~11.05 miles west of Charleston
  • Low-priced Highway property
  • Complimentary breakfast is offered
More Photos Photo of Best Western Plus Sikeston
From$69
Very Good 4.5 /5Recent Reviews CallBookMore Details
Americas Best Value Inn & Suites in Sikeston
+1-888-283-3404

How should we direct your call?

New Reservations: +1-888-283-3404 Group Sales: +1-888-494-8863 Front Desk: 15734719700
220 South Interstate Dr., Sikeston, MO 63801 ~11.09 miles west of Charleston
  • 2 star property
  • Check in time: 03:00 PM
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From$53
Very Good 4.0 /5Review Score CallBookMore Details
Quality Inn - Cairo
+1-866-221-8581

How should we direct your call?

New Reservations: +1-866-221-8581 Group Sales: +1-888-494-8863 Front Desk: 6187340215
13201 Kessler Rd., Cairo, IL 62914 ~11.20 miles northeast of Charleston
  • Three Star property
  • Check-in time: 11:00
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From$80
Very Good 4.0 /5Guest Reviews CallBookMore Details
Country Hearth Inn & Suites Sikeston
+1-866-429-5787

How should we direct your call?

New Reservations: +1-866-429-5787 Group Sales: +1-888-494-8863 Front Desk: 15734724400
100 Matthews Lane, Sikeston, MO 63801 ~11.37 miles west of Charleston
  • Low priced Highway property
  • 40 sleeping rooms in hotel
  • The majority of guests said rooms were dirty
  • Service could be improved
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From$60
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Comfort Inn & Suites
+1-888-690-5281

How should we direct your call?

New Reservations: +1-888-690-5281 Group Sales: +1-888-494-8863
109 Matthews Lane, Sikeston, MO 63801 ~11.37 miles west of Charleston
  • Three Star Highway hotel
  • 3 floors in property
  • Fantastic service
  • Excellent desk person
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From$80
Average 3.5 /5Guest Reviews CallBookMore Details
Drury Inn & Suites Sikeston : 2608 East Malone Ave.
+1-888-690-5247

How should we direct your call?

New Reservations: +1-888-690-5247 Group Sales: +1-888-494-8863 Front Desk: 18004361126
2608 East Malone Ave., Sikeston, MO 63801 ~11.45 miles west of Charleston
  • Three Star Highway property
  • 5 floors in hotel
  • Most guests enjoyed the snacks that were offered
  • Delicious food
More Photos Exterior of Drury Inn & Suites Sikeston
From$85
Very Good 4.5 /5Read Reviews CallBookMore Details
Super 8 in Sikeston
+1-888-305-3366

How should we direct your call?

New Reservations: +1-888-305-3366 Group Sales: +1-888-494-8863
2609 East Malone Ave., Sikeston, MO 63801 ~11.45 miles west of Charleston
  • Two star Convention Center property
  • 2 floors in hotel
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From$44
Average 3.0 /5Review Score CallBookMore Details
Pear Tree Inn Sikeston
+1-800-881-1523

How should we direct your call?

New Reservations: +1-800-881-1523 Group Sales: +1-888-494-8863 Front Desk: 18003250720
2602 East Malone, Sikeston, MO 63801 ~11.45 miles west of Charleston
  • 3-star Suburban hotel
  • 80 rooms in property
  • Most guests were happy with the price of the breakfast
  • Amenities are good
More Photos Photo of Pear Tree Inn Sikeston
From$75
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Holiday Inn Express & Suites Sikeston - Sikeston
+1-888-283-3404

How should we direct your call?

New Reservations: +1-888-283-3404 Group Sales: +1-888-494-8863 Front Desk: 15734759522
115 Hospitality Dr., Sikeston, MO 63801 ~14.33 miles west of Charleston
  • Low-priced property
  • 73 rooms in hotel
More Photos Photo of Holiday Inn Express & Suites Sikeston
From$60
Very Good 4.5 /5Guest Reviews CallBookMore Details
Days Inn Sikeston - Sikeston
+1-866-221-8581

How should we direct your call?

New Reservations: +1-866-221-8581 Group Sales: +1-888-494-8863
1330 South Main St., Sikeston, MO 63801 ~14.44 miles west of Charleston
  • Low-priced hotel
  • Check-in time: 11:00 AM
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From$60
Poor 2.0 /5Hotel Reviews CallBookMore Details
Americas Best Value Inn in Ullin
+1-866-429-5787

How should we direct your call?

New Reservations: +1-866-429-5787 Group Sales: +1-888-494-8863 Front Desk: 16188453700
128 Cheekwood Lane, Ullin, IL 62992 ~25.98 miles north of Charleston
  • Cheap property
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From$60
Very Good 4.0 /5Reviews CallBookMore Details
Candlewood Suites Cape Girardeau : 485 South Mount Auburn Rd.
+1-888-690-5281

How should we direct your call?

New Reservations: +1-888-690-5281 Group Sales: +1-888-494-8863 Front Desk: 15733346868
485 South Mount Auburn Rd., Cape Girardeau, MO 65703 ~28.61 miles northwest of Charleston
  • Low-priced Highway property
  • Fitness + Health Center
More Photos Exterior of Candlewood Suites Cape Girardeau
From$55
Very Good 4.0 /5Recent Reviews CallBookMore Details
Victorian Inn & Suites
+1-888-690-5247

How should we direct your call?

New Reservations: +1-888-690-5247 Group Sales: +1-888-494-8863
3256 William St., Cape Girardeau, MO 63703 ~29.40 miles northwest of Charleston
  • Three Star Golf Course hotel
  • Hotel has 5 suites
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From$79
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Auburn Place Hotel & Suites - Cape Girardeau
+1-888-305-3366

How should we direct your call?

New Reservations: +1-888-305-3366 Group Sales: +1-888-494-8863 Front Desk: 15736514486
3265 Williams St., Cape Girardeau, MO 63702 ~29.41 miles northwest of Charleston
  • Three Star Highway hotel
  • Check in time: 0300 pm
  • Room was fantastic
  • Most guests said the beds were comfortable
More Photos Image of Auburn Place Hotel & Suites
From$99
Very Good 4.0 /5Read Reviews CallBookMore Details
Holiday Inn Express & Suites Cape Girardeau I 55
+1-800-881-1523

How should we direct your call?

New Reservations: +1-800-881-1523 Group Sales: +1-888-494-8863
3253 William St., Cape Girardeau, MO 63701 ~29.43 miles northwest of Charleston
  • 2 star hotel
  • Fitness + Health Center
More Photos Image of Holiday Inn Express & Suites Cape Girardeau I 55
From$60
Very Good 4.5 /5Hotel Reviews CallBookMore Details
Pear Tree Inn Cape Girardeau West : 103 Cape West Pkwy.
+1-888-283-3404

How should we direct your call?

New Reservations: +1-888-283-3404 Group Sales: +1-888-494-8863 Front Desk: 18004361126
103 Cape West Pkwy., Cape Girardeau, MO 63701 ~29.49 miles northwest of Charleston
  • Low priced property
  • Free breakfast available
More Photos Image of Pear Tree Inn Cape Girardeau West
From$60
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Pear Tree Inn Cape Girardeau Medical Center : 3248 William St.
+1-866-221-8581

How should we direct your call?

New Reservations: +1-866-221-8581 Group Sales: +1-888-494-8863 Front Desk: 18004361126
3248 William St., Cape Girardeau, MO 63701 ~29.50 miles northwest of Charleston
  • Economical Highway hotel
  • 78 rooms in property
  • Great location for shopping
  • Perfectly clean
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From$66
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Drury Suites Cape Girardeau - Cape Girardeau
+1-866-429-5787

How should we direct your call?

New Reservations: +1-866-429-5787 Group Sales: +1-888-494-8863 Front Desk: 18004361126
3303 Campster Dr., Cape Girardeau, MO 63701 ~29.60 miles northwest of Charleston
  • Midscale Highway property
  • Complimentary breakfast is offered
  • Very clean and comfortable room
  • Clean Rooms
More Photos Image of Drury Suites Cape Girardeau
From$99
Very Good 4.5 /5Review Score CallBookMore Details
Drury Lodge Cape Girardeau in Cape Girardeau
+1-888-690-5281

How should we direct your call?

New Reservations: +1-888-690-5281 Group Sales: +1-888-494-8863 Front Desk: 18004361169
104 South Vantage Dr., Cape Girardeau, MO 63701 ~29.76 miles northwest of Charleston
  • Mid-scale Highway property
  • Comp. Breakfast
  • Older property
  • Average amenities
More Photos Exterior of Drury Lodge Cape Girardeau
From$89
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Travelodge
+1-888-690-5247

How should we direct your call?

New Reservations: +1-888-690-5247 Group Sales: +1-888-494-8863 Front Desk: 15736430075
301 Route Ad, Marston, MO 63866 ~31.28 miles southwest of Charleston
  • Low-priced Highway hotel
  • Check-in: 3:00 PM
More Photos Image of Travelodge
From$45
Average 3.0 /5Review Score CallBookMore Details
Super 8 Cape Girardeau : 2011 North Kingshighway
+1-888-305-3366

How should we direct your call?

New Reservations: +1-888-305-3366 Group Sales: +1-888-494-8863 Front Desk: 5733390808
2011 North Kingshighway, Cape Girardeau, MO 63701 ~31.73 miles northwest of Charleston
  • Cheap property
  • Check-in: 11:00 AM
More Photos Photo of Super 8 Cape Girardeau
From$60
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Comfort Suites Jackson / Cape Girardeau
+1-800-881-1523

How should we direct your call?

New Reservations: +1-800-881-1523 Group Sales: +1-888-494-8863 Front Desk: 15732040014
2904 Old Orchard Rd., Jackson, MO 63755 ~33.57 miles northwest of Charleston
  • Three Star Highway property
  • 64 rooms in hotel
  • Wonderful staff
  • Mirror was dirty
More Photos Exterior of Comfort Suites Jackson / Cape Girardeau
From$65
Very Good 4.0 /5Hotel Reviews CallBookMore Details
Residence Inn - Paducah
+1-888-283-3404

How should we direct your call?

New Reservations: +1-888-283-3404 Group Sales: +1-888-494-8863 Front Desk: 12704443966
3900 Coleman Crossing Circle, Paducah, KY 42001 ~34.97 miles east of Charleston
  • Affordable Suburban property
  • Complimentary breakfast is offered
  • Excellent amenities
  • Nice staff
More Photos Exterior of Residence Inn
From$89
Very Good 4.5 /5Review Score CallBookMore Details
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