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Charleston Missouri Hotels & Motels

Find the perfect hotel in Charleston using our hotel guide provided below. Find discounted hotel accommodations in or close to Charleston, MO for your upcoming individual or group travel. Discover the most popular Charleston, Missouri hotel and motel rooms. Browse the Charleston area hotels to find the perfect lodging! Please use the provided map of the Charleston hotels. Coordinating a group? Get Charleston Group Hotel Rates

Charleston Hotels, Motels & Accommodations

Super 8
+1-888-690-5247

How should we direct your call?

New Reservations: +1-888-690-5247 Group Sales: +1-888-494-8863 Front Desk: 15736832125
310 South Story, Charleston, MO 63834
  • Two star Highway hotel
  • 7 suites in hotel
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From$49
Average 3.5 /5Reviews CallBookMore Details
Quality Inn : 102 Drake St.
+1-888-305-3366

How should we direct your call?

New Reservations: +1-888-305-3366 Group Sales: +1-888-494-8863 Front Desk: 15736834200
102 Drake St., Charleston, MO 63834
  • Two-star Highway property
  • Hotel has 40 rooms
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From$67
Average 3.5 /5Read Reviews CallBookMore Details
Best Western Plus Sikeston in Sikeston
+1-800-881-1523

How should we direct your call?

New Reservations: +1-800-881-1523 Group Sales: +1-888-494-8863 Front Desk: 15734819500
120 South Interstate Dr., Sikeston, MO 63801 ~11.05 miles west of Charleston
  • Economy Highway property
  • Check in: 3:00 PM
More Photos Photo of Best Western Plus Sikeston
From$69
Very Good 4.5 /5Reviews CallBookMore Details
Americas Best Value Inn & Suites
+1-888-283-3404

How should we direct your call?

New Reservations: +1-888-283-3404 Group Sales: +1-888-494-8863 Front Desk: 15734719700
220 South Interstate Dr., Sikeston, MO 63801 ~11.09 miles west of Charleston
  • Low Cost hotel
  • Hotel has 60 rooms
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From$53
Very Good 4.0 /5Reviews CallBookMore Details
Quality Inn
+1-866-221-8581

How should we direct your call?

New Reservations: +1-866-221-8581 Group Sales: +1-888-494-8863 Front Desk: 6187340215
13201 Kessler Rd., Cairo, IL 62914 ~11.20 miles northeast of Charleston
  • Three Star hotel
  • Check in: 11:00
More Photos Image of Quality Inn
From$80
Very Good 4.0 /5Hotel Reviews CallBookMore Details
Country Hearth Inn & Suites Sikeston
+1-866-429-5787

How should we direct your call?

New Reservations: +1-866-429-5787 Group Sales: +1-888-494-8863 Front Desk: 15734724400
100 Matthews Lane, Sikeston, MO 63801 ~11.37 miles west of Charleston
  • Low-priced Highway property
  • Check in: 3:00 PM
  • Service is unsatisfactory
  • Average amenities
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From$60
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Comfort Inn & Suites : 109 Matthews Lane
+1-888-690-5281

How should we direct your call?

New Reservations: +1-888-690-5281 Group Sales: +1-888-494-8863
109 Matthews Lane, Sikeston, MO 63801 ~11.37 miles west of Charleston
  • 3 star Highway property
  • Fitness center on property
  • Location is ok
  • Staff friendly
More Photos Image of Comfort Inn & Suites
From$80
Average 3.5 /5Read Reviews CallBookMore Details
Drury Inn & Suites Sikeston : 2608 East Malone Ave.
+1-888-690-5247

How should we direct your call?

New Reservations: +1-888-690-5247 Group Sales: +1-888-494-8863 Front Desk: 18004361126
2608 East Malone Ave., Sikeston, MO 63801 ~11.45 miles west of Charleston
  • Midscale Highway hotel
  • 5 floors in hotel
  • Nice rooms
  • Great location
More Photos Photo of Drury Inn & Suites Sikeston
From$85
Very Good 4.5 /5Read Reviews CallBookMore Details
Super 8 : 2609 East Malone Ave.
+1-888-305-3366

How should we direct your call?

New Reservations: +1-888-305-3366 Group Sales: +1-888-494-8863
2609 East Malone Ave., Sikeston, MO 63801 ~11.45 miles west of Charleston
  • Low Cost Convention Center hotel
  • Check-in time: 01:00
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From$44
Average 3.0 /5Hotel Reviews CallBookMore Details
Pear Tree Inn Sikeston
+1-800-881-1523

How should we direct your call?

New Reservations: +1-800-881-1523 Group Sales: +1-888-494-8863 Front Desk: 18003250720
2602 East Malone, Sikeston, MO 63801 ~11.45 miles west of Charleston
  • Affordable Suburban property
  • Hotel has 2 suites
  • Staff was very helpful and accommodating
  • Most guests appreciated the modern rooms
More Photos Image of Pear Tree Inn Sikeston
From$75
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Holiday Inn Express & Suites Sikeston : 115 Hospitality Dr.
+1-888-283-3404

How should we direct your call?

New Reservations: +1-888-283-3404 Group Sales: +1-888-494-8863 Front Desk: 15734759522
115 Hospitality Dr., Sikeston, MO 63801 ~14.33 miles west of Charleston
  • Economical property
  • Fitness center on property
More Photos Exterior of Holiday Inn Express & Suites Sikeston
From$60
Very Good 4.5 /5Review Score CallBookMore Details
Days Inn Sikeston : 1330 South Main St.
+1-866-221-8581

How should we direct your call?

New Reservations: +1-866-221-8581 Group Sales: +1-888-494-8863
1330 South Main St., Sikeston, MO 63801 ~14.44 miles west of Charleston
  • 2 star hotel
  • Check-in time: 11:00 AM
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From$60
Poor 2.0 /5Read Reviews CallBookMore Details
Americas Best Value Inn
+1-866-429-5787

How should we direct your call?

New Reservations: +1-866-429-5787 Group Sales: +1-888-494-8863 Front Desk: 16188453700
128 Cheekwood Lane, Ullin, IL 62992 ~25.98 miles north of Charleston
  • 2 star hotel
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From$60
Very Good 4.0 /5Read Reviews CallBookMore Details
Candlewood Suites Cape Girardeau - Cape Girardeau
+1-888-690-5281

How should we direct your call?

New Reservations: +1-888-690-5281 Group Sales: +1-888-494-8863 Front Desk: 15733346868
485 South Mount Auburn Rd., Cape Girardeau, MO 65703 ~28.61 miles northwest of Charleston
  • Two-star Highway property
  • Has environment-friendly policy See more
More Photos Image of Candlewood Suites Cape Girardeau
From$55
Very Good 4.0 /5Read Reviews CallBookMore Details
Victorian Inn & Suites : 3256 William St.
+1-888-690-5247

How should we direct your call?

New Reservations: +1-888-690-5247 Group Sales: +1-888-494-8863
3256 William St., Cape Girardeau, MO 63703 ~29.40 miles northwest of Charleston
  • 3 star Golf Course property
  • 2 floors in hotel
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From$79
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Auburn Place Hotel & Suites
+1-888-305-3366

How should we direct your call?

New Reservations: +1-888-305-3366 Group Sales: +1-888-494-8863 Front Desk: 15736514486
3265 Williams St., Cape Girardeau, MO 63702 ~29.41 miles northwest of Charleston
  • Affordable Highway hotel
  • Access to gym on-site
  • Most guests enjoyed the restaurants & bars nearby
  • Easily accessible by car, said 100%
More Photos Photo of Auburn Place Hotel & Suites
From$99
Very Good 4.0 /5Latest Reviews CallBookMore Details
Holiday Inn Express & Suites Cape Girardeau I 55 in Cape Girardeau
+1-800-881-1523

How should we direct your call?

New Reservations: +1-800-881-1523 Group Sales: +1-888-494-8863
3253 William St., Cape Girardeau, MO 63701 ~29.43 miles northwest of Charleston
  • 2-star property
  • Hotel has 102 rooms
More Photos Exterior of Holiday Inn Express & Suites Cape Girardeau I 55
From$60
Very Good 4.5 /5Hotel Reviews CallBookMore Details
Pear Tree Inn Cape Girardeau West
+1-888-283-3404

How should we direct your call?

New Reservations: +1-888-283-3404 Group Sales: +1-888-494-8863 Front Desk: 18004361126
103 Cape West Pkwy., Cape Girardeau, MO 63701 ~29.49 miles northwest of Charleston
  • Two star hotel
  • 81 rooms in hotel
More Photos Exterior of Pear Tree Inn Cape Girardeau West
From$60
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Pear Tree Inn Cape Girardeau Medical Center in Cape Girardeau
+1-866-221-8581

How should we direct your call?

New Reservations: +1-866-221-8581 Group Sales: +1-888-494-8863 Front Desk: 18004361126
3248 William St., Cape Girardeau, MO 63701 ~29.50 miles northwest of Charleston
  • Cheap Highway property
  • Check-in: 3:00 pm
  • Clean pool
  • TV needs to be updated
More Photos Photo of Pear Tree Inn Cape Girardeau Medical Center
From$66
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Drury Suites Cape Girardeau in Cape Girardeau
+1-866-429-5787

How should we direct your call?

New Reservations: +1-866-429-5787 Group Sales: +1-888-494-8863 Front Desk: 18004361126
3303 Campster Dr., Cape Girardeau, MO 63701 ~29.60 miles northwest of Charleston
  • Three Star Highway property
  • Check in time: 3:00 PM
  • Fantastic service
  • Most guests thought it was clean
More Photos Photo of Drury Suites Cape Girardeau
From$99
Very Good 4.5 /5Review Score CallBookMore Details
Drury Lodge Cape Girardeau
+1-888-690-5281

How should we direct your call?

New Reservations: +1-888-690-5281 Group Sales: +1-888-494-8863 Front Desk: 18004361169
104 South Vantage Dr., Cape Girardeau, MO 63701 ~29.76 miles northwest of Charleston
  • 3 star Highway hotel
  • Check-in: 3:00pm
  • Rooms could be larger
  • Delicious food
More Photos Exterior of Drury Lodge Cape Girardeau
From$89
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Travelodge in Marston
+1-888-690-5247

How should we direct your call?

New Reservations: +1-888-690-5247 Group Sales: +1-888-494-8863 Front Desk: 15736430075
301 Route Ad, Marston, MO 63866 ~31.28 miles southwest of Charleston
  • Two-star Highway property
  • Check in: 3:00 PM
More Photos Image of Travelodge
From$40
Average 3.0 /5Reviews CallBookMore Details
Super 8 Cape Girardeau
+1-888-305-3366

How should we direct your call?

New Reservations: +1-888-305-3366 Group Sales: +1-888-494-8863 Front Desk: 5733390808
2011 North Kingshighway, Cape Girardeau, MO 63701 ~31.73 miles northwest of Charleston
  • Cheap hotel
  • Check in: 11:00 AM
More Photos Image of Super 8 Cape Girardeau
From$60
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Comfort Suites Jackson / Cape Girardeau in Jackson
+1-800-881-1523

How should we direct your call?

New Reservations: +1-800-881-1523 Group Sales: +1-888-494-8863 Front Desk: 15732040014
2904 Old Orchard Rd., Jackson, MO 63755 ~33.57 miles northwest of Charleston
  • Midscale Highway hotel
  • Hotel has an eco-friendly policy See policy
  • Mirror was dirty
  • Made our stay enjoyable
More Photos Photo of Comfort Suites Jackson / Cape Girardeau
From$65
Very Good 4.0 /5Guest Reviews CallBookMore Details
Residence Inn
+1-888-283-3404

How should we direct your call?

New Reservations: +1-888-283-3404 Group Sales: +1-888-494-8863 Front Desk: 12704443966
3900 Coleman Crossing Circle, Paducah, KY 42001 ~34.97 miles east of Charleston
  • Affordable Suburban property
  • Free complimentary breakfast
  • Every guests reviewed said rooms were clean
  • Decent breakfast
More Photos Photo of Residence Inn
From$89
Very Good 4.5 /5Read Reviews CallBookMore Details
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