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Charleston Missouri Hotels & Motels

Find the perfect hotel in Charleston using our hotel guide provided below. Find discounted hotel accommodations in or close to Charleston, MO for your upcoming individual or group travel. Discover the most popular Charleston, Missouri hotel and motel rooms. Browse the Charleston area hotels to find the perfect lodging! Please use the provided map of the Charleston hotels. Coordinating a group? Get Charleston Group Hotel Rates

Charleston Hotels & Accommodations

Super 8 in Charleston 310 South Story, Charleston, MO 63834
  • Two star Highway property
  • 60 rooms in property
From$45
Average 3.5 /5 Review Score Call BookMore Details
Quality Inn 102 Drake St., Charleston, MO 63834
  • Cheap Highway property
  • Free breakfast available
From$57
Average 3.5 /5 Latest Reviews Call BookMore Details
Best Western Plus Sikeston 120 South Interstate Dr., Sikeston, MO 63801 ~11.05 miles west of Charleston
  • 2 star Highway hotel
  • Check-in time: 3:00 PM
From$74
Very Good 4.5 /5 Review Score Call BookMore Details
Motel 6 Sikeston Mo 110 South Interstate Dr., Sikeston, MO 63801 ~11.07 miles west of Charleston
  • Low-priced hotel
  • Check in time: 14:00
From$60
Average 3.0 /5 Review Score Call BookMore Details
Americas Best Value Inn & Suites - Sikeston 220 South Interstate Dr., Sikeston, MO 63801 ~11.09 miles west of Charleston
  • Low Cost property
  • 60 suites in hotel
From$58
Average 3.5 /5 Read Reviews Call BookMore Details
Quality Inn - Cairo 13201 Kessler Rd., Cairo, IL 62914 ~11.20 miles northeast of Charleston
  • Mid-scale hotel
  • Comp. Breakfast
From$80
Average 3.5 /5 Reviews Call BookMore Details
Country Hearth Inn & Suites Sikeston 100 Matthews Lane, Sikeston, MO 63801 ~11.37 miles west of Charleston
  • 3 star Highway property
  • 2 floors in hotel
  • Rooms are ok
  • Location is great
From$80
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Comfort Inn & Suites in Sikeston
+1-888-690-5247
109 Matthews Lane, Sikeston, MO 63801 ~11.37 miles west of Charleston
  • Affordable Highway property
  • Hotel has 3 floors
  • Very good and friendly staff
  • Nice and clean facility
From$80
Average 3.5 /5 Recent Reviews Call BookMore Details
Drury Inn & Suites Sikeston in Sikeston 2608 East Malone Ave., Sikeston, MO 63801 ~11.45 miles west of Charleston
  • 3 star Highway property
  • Check-in: 3:00 PM
  • Clean facilities
  • Night stay for free
From$104
Very Good 4.5 /5 Read Reviews Call BookMore Details
Super 8 - Sikeston
+1-800-881-1523
2609 East Malone Ave., Sikeston, MO 63801 ~11.45 miles west of Charleston
  • 2 star Convention Center property
  • 62 sleeping rooms in hotel
From$44
Average 3.0 /5 Reviews Call BookMore Details
Pear Tree Inn Sikeston 2602 East Malone, Sikeston, MO 63801 ~11.45 miles west of Charleston
  • Affordable Suburban hotel
  • Gym / Fitness Center Available
  • Queen size beds
  • Most guests were happy with the price
Holiday Inn Express & Suites Sikeston 115 Hospitality Dr., Sikeston, MO 63801 ~14.33 miles west of Charleston
  • Low Cost hotel
From$60
Very Good 4.0 /5 Review Score Call BookMore Details
Days Inn Sikeston 1330 South Main St., Sikeston, MO 63801 ~14.44 miles west of Charleston
  • 2-star hotel
  • Check in time: 11:00 AM
Americas Best Value Inn - Ullin 128 Cheekwood Lane, Ullin, IL 62992 ~25.98 miles north of Charleston
  • Cheap hotel
  • Free complimentary breakfast
From$60
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Candlewood Suites Cape Girardeau : 485 South Mount Auburn Rd. 485 South Mount Auburn Rd., Cape Girardeau, MO 65703 ~28.61 miles northwest of Charleston
  • 2 star Highway hotel
  • 4 floors in property
From$62
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Hampton Inn Cape Girardeau I 55 East : 207 South Mt. Auburn Rd. 207 South Mt. Auburn Rd., Cape Girardeau, MO 63703 ~29.29 miles northwest of Charleston
  • 3 star property
From$79
Excellent 5.0 /5 Review Score Call BookMore Details
Auburn Place Hotel & Suites 3265 Williams St., Cape Girardeau, MO 63702 ~29.41 miles northwest of Charleston
  • Mid-scale Highway property
  • Comp. Breakfast
  • Quiet environment
  • Great desserts & fruits
From$65
Very Good 4.0 /5 Review Score Call BookMore Details
Holiday Inn Express & Suites Cape Girardeau I 55
+1-888-283-3404
3253 William St., Cape Girardeau, MO 63701 ~29.43 miles northwest of Charleston
  • Cheap property
  • Hotel has 102 rooms
From$60
Very Good 4.5 /5 Review Score Call BookMore Details
Pear Tree Inn Cape Girardeau West 103 Cape West Pkwy., Cape Girardeau, MO 63701 ~29.49 miles northwest of Charleston
  • Two-star hotel
  • Comp. Breakfast
Pear Tree Inn Cape Girardeau Medical Center 3248 William St., Cape Girardeau, MO 63701 ~29.50 miles northwest of Charleston
  • Economical Highway hotel
  • Check in time: 3:00 pm
  • Nice pool
  • Clean linen
Drury Suites Cape Girardeau in Cape Girardeau 3303 Campster Dr., Cape Girardeau, MO 63701 ~29.60 miles northwest of Charleston
  • Affordable Highway property
  • 79 suites in hotel
  • Convenient location
  • Excellent breakfast
From$104
Very Good 4.5 /5 Recent Reviews Call BookMore Details
Drury Lodge Cape Girardeau - Cape Girardeau 104 South Vantage Dr., Cape Girardeau, MO 63701 ~29.76 miles northwest of Charleston
  • Mid-scale Highway hotel
  • 8 meeting rooms in hotel
  • Nearby restaurants
  • Bathroom could be optimized
Drury Plaza Hotel & Conference Center Cape Girardeau - Cape Girardeau 3351 Percy Dr., Cape Girardeau, MO 63701 ~29.79 miles northwest of Charleston
  • Affordable hotel
  • Gym is available on property
Travelodge 301 Route Ad, Marston, MO 63866 ~31.28 miles southwest of Charleston
  • Low Cost Highway hotel
Americas Best Value Inn Cape Girardeau 2011 North Kingshighway, Cape Girardeau, MO 63701 ~31.73 miles northwest of Charleston
  • Two star property
  • 49 sleeping rooms in hotel
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