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Charleston Missouri Hotels & Motels

Find the perfect hotel in Charleston using our hotel guide provided below. Find discounted hotel accommodations in or close to Charleston, MO for your upcoming individual or group travel. Discover the most popular Charleston, Missouri hotel and motel rooms. Browse the Charleston area hotels to find the perfect lodging! Please use the provided map of the Charleston hotels. Coordinating a group? Get Charleston Group Hotel Rates

Charleston Hotels/Motels & Accommodations

Super 8 : 310 South Story
+1-888-690-5281

How should we direct your call?

New Reservations: +1-888-690-5281 Group Sales: +1-888-494-8863 Front Desk: 15736832125
310 South Story, Charleston, MO 63834
  • Inexpensive Highway property
  • Hotel has 60 rooms
More PhotosImage of Super 8
From$49
Average 3.5 /5Read Reviews Call
Quality Inn
+1-800-230-4134

How should we direct your call?

New Reservations: +1-800-230-4134 Group Sales: +1-888-494-8863 Front Desk: 15736834200
102 Drake St., Charleston, MO 63834
  • Economical Highway property
  • Gym / Fitness Center Available
More Photos Photo of Quality Inn
From$59
Average 3.5 /5Review Score Call
Eagle Inn in Charleston
+1-800-997-5148

How should we direct your call?

New Reservations: +1-800-997-5148 Group Sales: +1-888-494-8863
2811 East Marshall St., Charleston, MO 63834
  • Cheap hotel
  • Check-in time: 3:00PM
More Photos Image of Eagle Inn
From$44
Average 3.5 /5Hotel Reviews Call
Best Western Plus Sikeston
+1-888-690-5247

How should we direct your call?

New Reservations: +1-888-690-5247 Group Sales: +1-888-494-8863 Front Desk: 15734819500
120 South Interstate Dr., Sikeston, MO 63801 ~11.00 miles west of Charleston
  • Cheap Highway property
  • Free comp. breakfast
More Photos Photo of Best Western Plus Sikeston
From$89
Very Good 4.5 /5Recent Reviews Call
Americas Best Value Inn & Suites : 220 South Interstate Dr.
+1-888-305-3366

How should we direct your call?

New Reservations: +1-888-305-3366 Group Sales: +1-888-494-8863 Front Desk: 15734719700
220 South Interstate Dr., Sikeston, MO 63801 ~11.09 miles west of Charleston
  • 2 star hotel
  • 60 suites in hotel
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From$64
Average 3.5 /5Guest Reviews Call
Country Hearth Inn & Suites Sikeston
+1-800-881-1523

How should we direct your call?

New Reservations: +1-800-881-1523 Group Sales: +1-888-494-8863 Front Desk: 15734724400
100 Matthews Lane, Sikeston, MO 63801 ~11.36 miles west of Charleston
  • Two-star Highway property
  • Free breakfast available
More Photos Photo of Country Hearth Inn & Suites Sikeston
From$50
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Comfort Inn & Suites in Sikeston
+1-800-997-5149

How should we direct your call?

New Reservations: +1-800-997-5149 Group Sales: +1-888-494-8863
109 Matthews Lane, Sikeston, MO 63801 ~11.37 miles west of Charleston
  • Mid-scale Highway hotel
  • Free comp. breakfast
More Photos Exterior of Comfort Inn & Suites
From$80
Average 3.5 /5Guest Reviews Call
Drury Inn & Suites Sikeston
+1-888-690-5281

How should we direct your call?

New Reservations: +1-888-690-5281 Group Sales: +1-888-494-8863 Front Desk: 18004361169
2608 East Malone Ave., Sikeston, MO 63801 ~11.45 miles west of Charleston
  • Three Star Highway property
  • Fitness / Gym is on-site
More Photos Photo of Drury Inn & Suites Sikeston
From$109
Very Good 4.5 /5Read Reviews Call
Super 8
+1-800-230-4134

How should we direct your call?

New Reservations: +1-800-230-4134 Group Sales: +1-888-494-8863
2609 East Malone Ave., Sikeston, MO 63801 ~11.45 miles west of Charleston
  • Economy Convention Center property
  • 2 floors in hotel
More Photos Photo of Super 8
From$44
Average 3.0 /5Guest Reviews Call
Pear Tree Inn Sikeston : 2602 East Malone
+1-800-997-5148

How should we direct your call?

New Reservations: +1-800-997-5148 Group Sales: +1-888-494-8863 Front Desk: 18003250720
2602 East Malone, Sikeston, MO 63801 ~11.45 miles west of Charleston
  • Midscale Suburban property
  • Hotel has 80 rooms
More Photos Exterior of Pear Tree Inn Sikeston
From$69
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Candlewood Suites Cape Girardeau : 485 South Mount Auburn Rd.
+1-888-690-5247

How should we direct your call?

New Reservations: +1-888-690-5247 Group Sales: +1-888-494-8863 Front Desk: 15733346868
485 South Mount Auburn Rd., Cape Girardeau, MO 65703 ~28.61 miles northwest of Charleston
  • Low priced Highway hotel
  • Check-in time: 3:00PM
More Photos Photo of Candlewood Suites Cape Girardeau
From$76
Very Good 4.0 /5Hotel Reviews Call
Victorian Inn & Suites
+1-888-305-3366

How should we direct your call?

New Reservations: +1-888-305-3366 Group Sales: +1-888-494-8863
3256 William St., Cape Girardeau, MO 63703 ~29.40 miles northwest of Charleston
  • 3-star Golf Course property
  • Free breakfast available
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From$79
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Auburn Place Hotel & Suites in Cape Girardeau
+1-800-881-1523

How should we direct your call?

New Reservations: +1-800-881-1523 Group Sales: +1-888-494-8863 Front Desk: 15736514486
3265 Williams St., Cape Girardeau, MO 63702 ~29.41 miles northwest of Charleston
  • Affordable Highway property
  • 2 floors in hotel
More Photos Exterior of Auburn Place Hotel & Suites
From$99
Very Good 4.0 /5Review Score Call
Holiday Inn Express Hotel & Suites
+1-800-997-5149

How should we direct your call?

New Reservations: +1-800-997-5149 Group Sales: +1-888-494-8863
3253 William St., Cape Girardeau, MO 63701 ~29.49 miles northwest of Charleston
  • 3 star hotel
  • 3 meeting rooms in property
More Photos hotel room
From$112
Very Good 4.5 /5Latest Reviews Call
Pear Tree Inn Cape Girardeau West
+1-888-690-5281

How should we direct your call?

New Reservations: +1-888-690-5281 Group Sales: +1-888-494-8863 Front Desk: 18004361169
3248 William St., Cape Girardeau, MO 63701 ~29.50 miles northwest of Charleston
  • Two-star Highway property
  • Check-in time: 3:00 pm
More Photos Photo of Pear Tree Inn Cape Girardeau West
From$65
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Drury Suites Cape Girardeau
+1-800-230-4134

How should we direct your call?

New Reservations: +1-800-230-4134 Group Sales: +1-888-494-8863 Front Desk: 18004361169
3303 Campster Dr., Cape Girardeau, MO 63701 ~29.60 miles northwest of Charleston
  • Mid-scale Highway hotel
  • Free breakfast
More Photos Exterior of Drury Suites Cape Girardeau
From$124
Very Good 4.5 /5Reviews Call
Drury Lodge Cape Girardeau - Cape Girardeau
+1-800-997-5148

How should we direct your call?

New Reservations: +1-800-997-5148 Group Sales: +1-888-494-8863 Front Desk: 18004361169
104 South Vantage Dr., Cape Girardeau, MO 63701 ~29.76 miles northwest of Charleston
  • Mid-scale Highway hotel
  • Check-in: 3:00pm
More Photos Exterior of Drury Lodge Cape Girardeau
From$89
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Comfort Suites Jackson / Cape Girardeau - Jackson
+1-888-690-5247

How should we direct your call?

New Reservations: +1-888-690-5247 Group Sales: +1-888-494-8863 Front Desk: 15732040014
2904 Old Orchard Rd., Jackson, MO 63755 ~33.57 miles northwest of Charleston
  • Midscale Highway hotel
  • 3 floors in property
More Photos Photo of Comfort Suites Jackson / Cape Girardeau
From$75
Very Good 4.0 /5Reviews Call
Residence Inn : 3900 Coleman Crossing Circle
+1-888-305-3366

How should we direct your call?

New Reservations: +1-888-305-3366 Group Sales: +1-888-494-8863 Front Desk: 12704443966
3900 Coleman Crossing Circle, Paducah, KY 42001 ~34.97 miles east of Charleston
  • 3-star Suburban property
  • Check-in: 3:00PM
More Photos Photo of Residence Inn
From$90
Very Good 4.5 /5Recent Reviews Call
Pear Tree Inn Paducah - Paducah
+1-800-881-1523

How should we direct your call?

New Reservations: +1-800-881-1523 Group Sales: +1-888-494-8863 Front Desk: 18003250720
5006 Hinkleville Rd., Paducah, KY 42001 ~35.47 miles east of Charleston
  • Cheap Suburban hotel
  • Check-in time: 3:00 PM
More Photos Exterior of Pear Tree Inn Paducah
From$62
Very Good 4.0 /5Latest Reviews Call
Econo Lodge Dexter - Dexter
+1-800-997-5149

How should we direct your call?

New Reservations: +1-800-997-5149 Group Sales: +1-888-494-8863 Front Desk: 15736247400
913 Outer Rd., Dexter, MO 63841 ~36.06 miles west of Charleston
  • Low priced property
  • Hotel has 6 suites
More Photos hotel room
From$49
Average 3.0 /5Read Reviews Call
Baymont Inn & Suites Metropolis Il - Metropolis
+1-888-690-5281

How should we direct your call?

New Reservations: +1-888-690-5281 Group Sales: +1-888-494-8863 Front Desk: 16185245678
203 East Front St., Metropolis, IL 62960 ~36.55 miles east of Charleston
  • Cheap Riverfront hotel
  • 8 suites in property
More Photos Photo of Baymont Inn & Suites Metropolis Il
From$35
Average 3.5 /5Read Reviews Call
Hickory House Inn
+1-800-230-4134

How should we direct your call?

New Reservations: +1-800-230-4134 Group Sales: +1-888-494-8863
1802 North Outer Rd., Dexter, MO 63841 ~37.17 miles west of Charleston
  • 2-star property
  • Comp. Breakfast
More Photos Photo of Hickory House Inn
From$54
Poor 2.0 /5Read Reviews Call
Drury Suites Paducah
+1-800-997-5148

How should we direct your call?

New Reservations: +1-800-997-5148 Group Sales: +1-888-494-8863 Front Desk: 18004361169
2930 James Sanders Blvd., Paducah, KY 42001 ~37.34 miles east of Charleston
  • 3-star Suburban hotel
  • 2 meeting rooms in property
More Photos Photo of Drury Suites Paducah
From$114
Very Good 4.5 /5Review Score Call
Quality Suites : 2880 James Sanders Blvd.
+1-888-690-5247

How should we direct your call?

New Reservations: +1-888-690-5247 Group Sales: +1-888-494-8863 Front Desk: 12704422080
2880 James Sanders Blvd., Paducah, KY 42001 ~37.41 miles east of Charleston
  • Midscale Highway hotel
  • Hotel has 59 suites
More Photos Image of Quality Suites
From$60
Very Good 4.0 /5Guest Reviews Call
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