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Charleston Missouri Hotels & Motels

Find the perfect hotel in Charleston using our hotel guide provided below. Find discounted hotel accommodations in or close to Charleston, MO for your upcoming individual or group travel. Discover the most popular Charleston, Missouri hotel and motel rooms. Browse the Charleston area hotels to find the perfect lodging! Please use the provided map of the Charleston hotels. Coordinating a group? Get Charleston Group Hotel Rates

Charleston Hotels & Accommodations

Super 8 in Charleston
+1-888-690-5247

How should we direct your call?

New Reservations: +1-888-690-5247 Group Sales: +1-888-494-8863 Front Desk: 15736832125
310 South Story, Charleston, MO 63834
  • Two star Highway property
  • 60 rooms in property
More Photos Photo of Super 8
From$45
Average 3.5 /5 Review Score Call BookMore Details
Quality Inn
+1-888-305-3366

How should we direct your call?

New Reservations: +1-888-305-3366 Group Sales: +1-888-494-8863 Front Desk: 15736834200
102 Drake St., Charleston, MO 63834
  • Cheap Highway property
  • Free breakfast available
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From$57
Average 3.5 /5 Latest Reviews Call BookMore Details
Best Western Plus Sikeston
+1-800-881-1523

How should we direct your call?

New Reservations: +1-800-881-1523 Group Sales: +1-888-494-8863 Front Desk: 15734819500
120 South Interstate Dr., Sikeston, MO 63801 ~11.05 miles west of Charleston
  • 2 star Highway hotel
  • Check-in time: 3:00 PM
More Photos Image of Best Western Plus Sikeston
From$74
Very Good 4.5 /5 Review Score Call BookMore Details
Motel 6 Sikeston Mo
+1-888-283-3404

How should we direct your call?

New Reservations: +1-888-283-3404 Group Sales: +1-888-494-8863 Front Desk: 5734717400
110 South Interstate Dr., Sikeston, MO 63801 ~11.07 miles west of Charleston
  • Low-priced hotel
  • Check in time: 14:00
More Photos Exterior of Motel 6 Sikeston Mo
From$60
Average 3.0 /5 Review Score Call BookMore Details
Americas Best Value Inn & Suites - Sikeston
+1-866-221-8581

How should we direct your call?

New Reservations: +1-866-221-8581 Group Sales: +1-888-494-8863 Front Desk: 15734719700
220 South Interstate Dr., Sikeston, MO 63801 ~11.09 miles west of Charleston
  • Low Cost property
  • 60 suites in hotel
More Photos Image of Americas Best Value Inn & Suites
From$58
Average 3.5 /5 Read Reviews Call BookMore Details
Quality Inn - Cairo
+1-866-429-5787

How should we direct your call?

New Reservations: +1-866-429-5787 Group Sales: +1-888-494-8863 Front Desk: 6187340215
13201 Kessler Rd., Cairo, IL 62914 ~11.20 miles northeast of Charleston
  • Mid-scale hotel
  • Comp. Breakfast
More Photos Photo of Quality Inn
From$80
Average 3.5 /5 Reviews Call BookMore Details
Country Hearth Inn & Suites Sikeston
+1-888-690-5281

How should we direct your call?

New Reservations: +1-888-690-5281 Group Sales: +1-888-494-8863 Front Desk: 15734724400
100 Matthews Lane, Sikeston, MO 63801 ~11.37 miles west of Charleston
  • 3 star Highway property
  • 2 floors in hotel
  • Rooms are ok
  • Location is great
More Photos Exterior of Country Hearth Inn & Suites Sikeston
From$80
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Comfort Inn & Suites in Sikeston
+1-888-690-5247

How should we direct your call?

New Reservations: +1-888-690-5247 Group Sales: +1-888-494-8863
109 Matthews Lane, Sikeston, MO 63801 ~11.37 miles west of Charleston
  • Affordable Highway property
  • Hotel has 3 floors
  • Very good and friendly staff
  • Nice and clean facility
More Photos Image of Comfort Inn & Suites
From$80
Average 3.5 /5 Recent Reviews Call BookMore Details
Drury Inn & Suites Sikeston in Sikeston
+1-888-305-3366

How should we direct your call?

New Reservations: +1-888-305-3366 Group Sales: +1-888-494-8863 Front Desk: 18004361126
2608 East Malone Ave., Sikeston, MO 63801 ~11.45 miles west of Charleston
  • 3 star Highway property
  • Check-in: 3:00 PM
  • Clean facilities
  • Night stay for free
More Photos Image of Drury Inn & Suites Sikeston
From$104
Very Good 4.5 /5 Read Reviews Call BookMore Details
Super 8 - Sikeston
+1-800-881-1523

How should we direct your call?

New Reservations: +1-800-881-1523 Group Sales: +1-888-494-8863
2609 East Malone Ave., Sikeston, MO 63801 ~11.45 miles west of Charleston
  • 2 star Convention Center property
  • 62 sleeping rooms in hotel
More Photos Exterior of Super 8
From$44
Average 3.0 /5 Reviews Call BookMore Details
Pear Tree Inn Sikeston
+1-888-283-3404

How should we direct your call?

New Reservations: +1-888-283-3404 Group Sales: +1-888-494-8863 Front Desk: 18003250720
2602 East Malone, Sikeston, MO 63801 ~11.45 miles west of Charleston
  • Affordable Suburban hotel
  • Gym / Fitness Center Available
  • Queen size beds
  • Most guests were happy with the price
More Photos Photo of Pear Tree Inn Sikeston
From$75
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Holiday Inn Express & Suites Sikeston
+1-866-221-8581

How should we direct your call?

New Reservations: +1-866-221-8581 Group Sales: +1-888-494-8863 Front Desk: 15734759522
115 Hospitality Dr., Sikeston, MO 63801 ~14.33 miles west of Charleston
  • Low Cost hotel
More Photos Exterior of Holiday Inn Express & Suites Sikeston
From$60
Very Good 4.0 /5 Review Score Call BookMore Details
Days Inn Sikeston
+1-866-429-5787

How should we direct your call?

New Reservations: +1-866-429-5787 Group Sales: +1-888-494-8863 Front Desk: 5734713930
1330 South Main St., Sikeston, MO 63801 ~14.44 miles west of Charleston
  • 2-star hotel
  • Check in time: 11:00 AM
More Photos Photo of Days Inn Sikeston
From$60
Poor 2.0 /5 Recent Reviews Call BookMore Details
Americas Best Value Inn - Ullin
+1-888-690-5281

How should we direct your call?

New Reservations: +1-888-690-5281 Group Sales: +1-888-494-8863 Front Desk: 16188453700
128 Cheekwood Lane, Ullin, IL 62992 ~25.98 miles north of Charleston
  • Cheap hotel
  • Free complimentary breakfast
More Photos Photo of Americas Best Value Inn
From$60
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Candlewood Suites Cape Girardeau : 485 South Mount Auburn Rd.
+1-888-690-5247

How should we direct your call?

New Reservations: +1-888-690-5247 Group Sales: +1-888-494-8863 Front Desk: 15733346868
485 South Mount Auburn Rd., Cape Girardeau, MO 65703 ~28.61 miles northwest of Charleston
  • 2 star Highway hotel
  • 4 floors in property
More Photos Exterior of Candlewood Suites Cape Girardeau
From$62
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Hampton Inn Cape Girardeau I 55 East : 207 South Mt. Auburn Rd.
+1-888-305-3366

How should we direct your call?

New Reservations: +1-888-305-3366 Group Sales: +1-888-494-8863 Front Desk: 15733344499
207 South Mt. Auburn Rd., Cape Girardeau, MO 63703 ~29.29 miles northwest of Charleston
  • 3 star property
More Photos Image of Hampton Inn Cape Girardeau I 55 East
From$79
Excellent 5.0 /5 Review Score Call BookMore Details
Auburn Place Hotel & Suites
+1-800-881-1523

How should we direct your call?

New Reservations: +1-800-881-1523 Group Sales: +1-888-494-8863 Front Desk: 15736514486
3265 Williams St., Cape Girardeau, MO 63702 ~29.41 miles northwest of Charleston
  • Mid-scale Highway property
  • Comp. Breakfast
  • Quiet environment
  • Great desserts & fruits
More Photos Photo of Auburn Place Hotel & Suites
From$65
Very Good 4.0 /5 Review Score Call BookMore Details
Holiday Inn Express & Suites Cape Girardeau I 55
+1-888-283-3404

How should we direct your call?

New Reservations: +1-888-283-3404 Group Sales: +1-888-494-8863
3253 William St., Cape Girardeau, MO 63701 ~29.43 miles northwest of Charleston
  • Cheap property
  • Hotel has 102 rooms
More Photos Image of Holiday Inn Express & Suites Cape Girardeau I 55
From$60
Very Good 4.5 /5 Review Score Call BookMore Details
Pear Tree Inn Cape Girardeau West
+1-866-221-8581

How should we direct your call?

New Reservations: +1-866-221-8581 Group Sales: +1-888-494-8863 Front Desk: 18004361126
103 Cape West Pkwy., Cape Girardeau, MO 63701 ~29.49 miles northwest of Charleston
  • Two-star hotel
  • Comp. Breakfast
More Photos Image of Pear Tree Inn Cape Girardeau West
From$60
Call BookMore Details
Pear Tree Inn Cape Girardeau Medical Center
+1-866-429-5787

How should we direct your call?

New Reservations: +1-866-429-5787 Group Sales: +1-888-494-8863 Front Desk: 18004361126
3248 William St., Cape Girardeau, MO 63701 ~29.50 miles northwest of Charleston
  • Economical Highway hotel
  • Check in time: 3:00 pm
  • Nice pool
  • Clean linen
More Photos Exterior of Pear Tree Inn Cape Girardeau Medical Center
From$66
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Drury Suites Cape Girardeau in Cape Girardeau
+1-888-690-5281

How should we direct your call?

New Reservations: +1-888-690-5281 Group Sales: +1-888-494-8863 Front Desk: 18004361126
3303 Campster Dr., Cape Girardeau, MO 63701 ~29.60 miles northwest of Charleston
  • Affordable Highway property
  • 79 suites in hotel
  • Convenient location
  • Excellent breakfast
More Photos Image of Drury Suites Cape Girardeau
From$104
Very Good 4.5 /5 Recent Reviews Call BookMore Details
Drury Lodge Cape Girardeau - Cape Girardeau
+1-888-690-5247

How should we direct your call?

New Reservations: +1-888-690-5247 Group Sales: +1-888-494-8863 Front Desk: 18004361169
104 South Vantage Dr., Cape Girardeau, MO 63701 ~29.76 miles northwest of Charleston
  • Mid-scale Highway hotel
  • 8 meeting rooms in hotel
  • Nearby restaurants
  • Bathroom could be optimized
More Photos Exterior of Drury Lodge Cape Girardeau
From$89
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Drury Plaza Hotel & Conference Center Cape Girardeau - Cape Girardeau
+1-888-305-3366

How should we direct your call?

New Reservations: +1-888-305-3366 Group Sales: +1-888-494-8863 Front Desk: 15733347151
3351 Percy Dr., Cape Girardeau, MO 63701 ~29.79 miles northwest of Charleston
  • Affordable hotel
  • Gym is available on property
More Photos Exterior of Drury Plaza Hotel & Conference Center Cape Girardeau
From$80
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Travelodge
+1-800-881-1523

How should we direct your call?

New Reservations: +1-800-881-1523 Group Sales: +1-888-494-8863 Front Desk: 15736430075
301 Route Ad, Marston, MO 63866 ~31.28 miles southwest of Charleston
  • Low Cost Highway hotel
More Photos Exterior of Travelodge
From$40
Poor 2.5 /5 Hotel Reviews Call BookMore Details
Americas Best Value Inn Cape Girardeau
+1-888-283-3404

How should we direct your call?

New Reservations: +1-888-283-3404 Group Sales: +1-888-494-8863 Front Desk: 5733390808
2011 North Kingshighway, Cape Girardeau, MO 63701 ~31.73 miles northwest of Charleston
  • Two star property
  • 49 sleeping rooms in hotel
More Photos Exterior of Americas Best Value Inn Cape Girardeau
From$60
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