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Charleston Missouri Hotels & Motels

Find the perfect hotel in Charleston using our hotel guide provided below. Find discounted hotel accommodations in or close to Charleston, MO for your upcoming individual or group travel. Discover the most popular Charleston, Missouri hotel and motel rooms. Browse the Charleston area hotels to find the perfect lodging! Please use the provided map of the Charleston hotels. Coordinating a group? Get Charleston Group Hotel Rates

Charleston Hotels/Motels & Accommodations

Super 8
+1-888-690-5247

How should we direct your call?

New Reservations: +1-888-690-5247 Group Sales: +1-888-494-8863 Front Desk: 1-573-683-2125
310 South Story, Charleston, MO 63834
  • Low priced Highway hotel
  • Free comp. breakfast
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From$49
Average 3.5 /5Review Score CallBookMore Details
Quality Inn : 102 Drake St.
+1-888-305-3366

How should we direct your call?

New Reservations: +1-888-305-3366 Group Sales: +1-888-494-8863 Front Desk: 1-573-683-4200
102 Drake St., Charleston, MO 63834
  • Low-priced Highway property
  • 9 suites in hotel
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From$67
Average 3.5 /5Hotel Reviews CallBookMore Details
Best Western Plus Sikeston : 120 South Interstate Dr.
+1-800-881-1523

How should we direct your call?

New Reservations: +1-800-881-1523 Group Sales: +1-888-494-8863 Front Desk: 1-573-481-9500
120 South Interstate Dr., Sikeston, MO 63801 ~11.05 miles west of Charleston
  • Inexpensive Highway hotel
  • Hotel has 55 rooms
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From$75
Very Good 4.5 /5Review Score CallBookMore Details
Americas Best Value Inn & Suites : 220 South Interstate Dr.
+1-888-283-3404

How should we direct your call?

New Reservations: +1-888-283-3404 Group Sales: +1-888-494-8863 Front Desk: 1-573-471-9700
220 South Interstate Dr., Sikeston, MO 63801 ~11.09 miles west of Charleston
  • Economy hotel
  • 60 suites in property
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From$53
Average 3.5 /5Read Reviews CallBookMore Details
Quality Inn
+1-866-221-8581

How should we direct your call?

New Reservations: +1-866-221-8581 Group Sales: +1-888-494-8863 Front Desk: 1-618-734-0215
13201 Kessler Rd., Cairo, IL 62914 ~11.20 miles northeast of Charleston
  • 3 star property
  • Check-in time: 11:00
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From$80
Average 3.5 /5Latest Reviews CallBookMore Details
Country Hearth Inn & Suites Sikeston
+1-866-429-5787

How should we direct your call?

New Reservations: +1-866-429-5787 Group Sales: +1-888-494-8863 Front Desk: 1-573-472-4400
100 Matthews Lane, Sikeston, MO 63801 ~11.37 miles west of Charleston
  • Inexpensive Highway property
  • Hotel has 40 rooms
  • Good parking spaces
  • Bed was comfortable
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From$60
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Comfort Inn & Suites
+1-888-690-5281

How should we direct your call?

New Reservations: +1-888-690-5281 Group Sales: +1-888-494-8863
109 Matthews Lane, Sikeston, MO 63801 ~11.37 miles west of Charleston
  • 3-star Highway property
  • Check in: 02:00 PM
  • Nice indoor pool and fitness room
  • Most guests said the reception staff was great
More Photos Exterior of Comfort Inn & Suites
From$80
Average 3.5 /5Reviews CallBookMore Details
Drury Inn & Suites Sikeston
+1-888-690-5247

How should we direct your call?

New Reservations: +1-888-690-5247 Group Sales: +1-888-494-8863 Front Desk: 1-800-436-1126
2608 East Malone Ave., Sikeston, MO 63801 ~11.45 miles west of Charleston
  • 3-star Highway hotel
  • Has environment-friendly policy See more
  • Clean
  • Great room
More Photos Image of Drury Inn & Suites Sikeston
From$85
Very Good 4.5 /5Guest Reviews CallBookMore Details
Super 8
+1-888-305-3366

How should we direct your call?

New Reservations: +1-888-305-3366 Group Sales: +1-888-494-8863
2609 East Malone Ave., Sikeston, MO 63801 ~11.45 miles west of Charleston
  • Low Cost Convention Center hotel
  • 62 rooms in property
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From$44
Average 3.0 /5Reviews CallBookMore Details
Pear Tree Inn Sikeston in Sikeston
+1-800-881-1523

How should we direct your call?

New Reservations: +1-800-881-1523 Group Sales: +1-888-494-8863 Front Desk: 1-800-325-0720
2602 East Malone, Sikeston, MO 63801 ~11.45 miles west of Charleston
  • Affordable Suburban property
  • 4 floors in property
  • Most guests said the reception staff was great
  • Desk clerk was very friendly and courteous
More Photos Image of Pear Tree Inn Sikeston
From$75
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Holiday Inn Express & Suites Sikeston : 115 Hospitality Dr.
+1-888-283-3404

How should we direct your call?

New Reservations: +1-888-283-3404 Group Sales: +1-888-494-8863 Front Desk: 1-573-475-9522
115 Hospitality Dr., Sikeston, MO 63801 ~14.33 miles west of Charleston
  • Inexpensive property
  • Fitness / Gym is on-site
More Photos Exterior of Holiday Inn Express & Suites Sikeston
From$60
Very Good 4.5 /5Latest Reviews CallBookMore Details
Days Inn Sikeston : 1330 South Main St.
+1-866-221-8581

How should we direct your call?

New Reservations: +1-866-221-8581 Group Sales: +1-888-494-8863
1330 South Main St., Sikeston, MO 63801 ~14.44 miles west of Charleston
  • Economy hotel
  • Check-in: 11:00 AM
More Photos Image of Days Inn Sikeston
From$60
Poor 2.0 /5Reviews CallBookMore Details
Americas Best Value Inn
+1-866-429-5787

How should we direct your call?

New Reservations: +1-866-429-5787 Group Sales: +1-888-494-8863 Front Desk: 1-618-845-3700
128 Cheekwood Lane, Ullin, IL 62992 ~25.98 miles north of Charleston
  • Cheap property
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From$60
Very Good 4.0 /5Latest Reviews CallBookMore Details
Candlewood Suites Cape Girardeau - Cape Girardeau
+1-888-690-5281

How should we direct your call?

New Reservations: +1-888-690-5281 Group Sales: +1-888-494-8863 Front Desk: 1-573-334-6868
485 South Mount Auburn Rd., Cape Girardeau, MO 65703 ~28.61 miles northwest of Charleston
  • 2 star Highway property
  • 4 floors in hotel
More Photos Photo of Candlewood Suites Cape Girardeau
From$55
Very Good 4.0 /5Review Score CallBookMore Details
Victorian Inn & Suites in Cape Girardeau
+1-888-690-5247

How should we direct your call?

New Reservations: +1-888-690-5247 Group Sales: +1-888-494-8863
3256 William St., Cape Girardeau, MO 63703 ~29.40 miles northwest of Charleston
  • 3 star Golf Course hotel
  • Hotel has 2 floors
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From$79
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Auburn Place Hotel & Suites in Cape Girardeau
+1-888-305-3366

How should we direct your call?

New Reservations: +1-888-305-3366 Group Sales: +1-888-494-8863 Front Desk: 1-573-651-4486
3265 Williams St., Cape Girardeau, MO 63702 ~29.41 miles northwest of Charleston
  • 3-star Highway property
  • 5 suites in hotel
  • Giant hot tub
  • Room was clean
More Photos Image of Auburn Place Hotel & Suites
From$99
Very Good 4.0 /5Review Score CallBookMore Details
Holiday Inn Express & Suites Cape Girardeau I 55 : 3253 William St.
+1-800-881-1523

How should we direct your call?

New Reservations: +1-800-881-1523 Group Sales: +1-888-494-8863
3253 William St., Cape Girardeau, MO 63701 ~29.43 miles northwest of Charleston
  • Low-priced property
  • Fitness + Health Center
More Photos Exterior of Holiday Inn Express & Suites Cape Girardeau I 55
From$60
Very Good 4.5 /5Read Reviews CallBookMore Details
Pear Tree Inn Cape Girardeau West
+1-888-283-3404

How should we direct your call?

New Reservations: +1-888-283-3404 Group Sales: +1-888-494-8863 Front Desk: 1-800-436-1126
103 Cape West Pkwy., Cape Girardeau, MO 63701 ~29.49 miles northwest of Charleston
  • 2 star hotel
  • Free breakfast available
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From$60
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Pear Tree Inn Cape Girardeau Medical Center : 3248 William St.
+1-866-221-8581

How should we direct your call?

New Reservations: +1-866-221-8581 Group Sales: +1-888-494-8863 Front Desk: 1-800-436-1126
3248 William St., Cape Girardeau, MO 63701 ~29.50 miles northwest of Charleston
  • Economical Highway property
  • Check-in time: 3:00 pm
  • Clean bed
  • Very quiet
More Photos Photo of Pear Tree Inn Cape Girardeau Medical Center
From$66
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Drury Suites Cape Girardeau in Cape Girardeau
+1-866-429-5787

How should we direct your call?

New Reservations: +1-866-429-5787 Group Sales: +1-888-494-8863 Front Desk: 1-800-436-1126
3303 Campster Dr., Cape Girardeau, MO 63701 ~29.60 miles northwest of Charleston
  • Affordable Highway property
  • Gym / Fitness Center Available
  • Pool is below average
  • Decent food
More Photos Photo of Drury Suites Cape Girardeau
From$99
Very Good 4.5 /5Review Score CallBookMore Details
Drury Lodge Cape Girardeau : 104 South Vantage Dr.
+1-888-690-5281

How should we direct your call?

New Reservations: +1-888-690-5281 Group Sales: +1-888-494-8863 Front Desk: 1-800-436-1169
104 South Vantage Dr., Cape Girardeau, MO 63701 ~29.76 miles northwest of Charleston
  • Affordable Highway hotel
  • 8 meeting rooms in property
  • Most guests thought beverage prices were a great value
  • Right by the highway
More Photos Photo of Drury Lodge Cape Girardeau
From$89
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Drury Plaza Hotel & Conference Center Cape Girardeau
+1-888-690-5247

How should we direct your call?

New Reservations: +1-888-690-5247 Group Sales: +1-888-494-8863 Front Desk: 1-573-334-7151
3351 Percy Dr., Cape Girardeau, MO 63701 ~29.79 miles northwest of Charleston
  • Midscale hotel
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From$80
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Travelodge in Marston
+1-888-305-3366

How should we direct your call?

New Reservations: +1-888-305-3366 Group Sales: +1-888-494-8863 Front Desk: 1-573-643-0075
301 Route Ad, Marston, MO 63866 ~31.28 miles southwest of Charleston
  • Inexpensive Highway property
  • Check-in time: 3:00 PM
More Photos Image of Travelodge
From$40
Average 3.0 /5Read Reviews CallBookMore Details
Super 8 Cape Girardeau - Cape Girardeau
+1-800-881-1523

How should we direct your call?

New Reservations: +1-800-881-1523 Group Sales: +1-888-494-8863 Front Desk: 1-573-339-0808
2011 North Kingshighway, Cape Girardeau, MO 63701 ~31.73 miles northwest of Charleston
  • Low Cost property
  • Check in time: 11:00 AM
More Photos Photo of Super 8 Cape Girardeau
From$60
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Comfort Suites Jackson / Cape Girardeau
+1-888-283-3404

How should we direct your call?

New Reservations: +1-888-283-3404 Group Sales: +1-888-494-8863 Front Desk: 1-573-204-0014
2904 Old Orchard Rd., Jackson, MO 63755 ~33.57 miles northwest of Charleston
  • 3-star Highway hotel
  • 64 suites in property
  • Most guests thought they were poorly maintained
  • Easily accessible by car, said 100%
More Photos Photo of Comfort Suites Jackson / Cape Girardeau
From$65
Very Good 4.0 /5Recent Reviews CallBookMore Details
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