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Charleston Missouri Hotels & Motels

Find the perfect hotel in Charleston using our hotel guide provided below. Find discounted hotel accommodations in or close to Charleston, MO for your upcoming individual or group travel. Discover the most popular Charleston, Missouri hotel and motel rooms. Browse the Charleston area hotels to find the perfect lodging! Please use the provided map of the Charleston hotels. Coordinating a group? Get Charleston Group Hotel Rates

Charleston Hotels, Motels & Accommodations

Super 8 - Charleston
+1-888-690-5247

How should we direct your call?

New Reservations: +1-888-690-5247 Group Sales: +1-888-494-8863 Front Desk: 15736832125
310 South Story, Charleston, MO 63834
  • Cheap Highway property
  • 7 suites in property
More PhotosPhoto of Super 8
From$45
Average 3.5 /5Recent Reviews CallBookMore Details
Quality Inn - Charleston
+1-888-305-3366

How should we direct your call?

New Reservations: +1-888-305-3366 Group Sales: +1-888-494-8863 Front Desk: 15736834200
102 Drake St., Charleston, MO 63834
  • Two star Highway property
  • 40 sleeping rooms in hotel
More Photos Image of Quality Inn
From$57
Average 3.5 /5Latest Reviews CallBookMore Details
Best Western Plus Sikeston
+1-800-881-1523

How should we direct your call?

New Reservations: +1-800-881-1523 Group Sales: +1-888-494-8863 Front Desk: 15734819500
120 South Interstate Dr., Sikeston, MO 63801 ~11.05 miles west of Charleston
  • Economical Highway property
  • Hotel has 2 floors
More Photos Photo of Best Western Plus Sikeston
From$74
Very Good 4.5 /5Read Reviews CallBookMore Details
Motel 6 Sikeston Mo - Sikeston
+1-888-283-3404

How should we direct your call?

New Reservations: +1-888-283-3404 Group Sales: +1-888-494-8863 Front Desk: 5734717400
110 South Interstate Dr., Sikeston, MO 63801 ~11.07 miles west of Charleston
  • Inexpensive hotel
  • Hotel has 46 rooms
More Photos Photo of Motel 6 Sikeston Mo
From$60
Average 3.0 /5Guest Reviews CallBookMore Details
Americas Best Value Inn & Suites - Sikeston
+1-866-221-8581

How should we direct your call?

New Reservations: +1-866-221-8581 Group Sales: +1-888-494-8863 Front Desk: 15734719700
220 South Interstate Dr., Sikeston, MO 63801 ~11.09 miles west of Charleston
  • Economy property
  • Hotel has 60 suites
More Photos Image of Americas Best Value Inn & Suites
From$62
Average 3.5 /5Reviews CallBookMore Details
Quality Inn - Cairo
+1-866-429-5787

How should we direct your call?

New Reservations: +1-866-429-5787 Group Sales: +1-888-494-8863
13201 Kessler Rd., Cairo, IL 62914 ~11.20 miles northeast of Charleston
  • Affordable hotel
  • 38 sleeping rooms in hotel
  • Almost all guests complained about the bathroom
  • Bed was comfortable
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From$80
Average 3.5 /5Latest Reviews CallBookMore Details
Country Hearth Inn & Suites Sikeston
+1-888-690-5281

How should we direct your call?

New Reservations: +1-888-690-5281 Group Sales: +1-888-494-8863 Front Desk: 15734724400
100 Matthews Lane, Sikeston, MO 63801 ~11.37 miles west of Charleston
  • Three Star Highway property
  • Free breakfast
  • Worst customer service
  • Good parking spaces
More Photos Exterior of Country Hearth Inn & Suites Sikeston
From$80
Very Good 4.5 /5Guest Reviews CallBookMore Details
Comfort Inn in Sikeston
+1-888-690-5247

How should we direct your call?

New Reservations: +1-888-690-5247 Group Sales: +1-888-494-8863
109 Matthews Lane, Sikeston, MO 63801 ~11.40 miles west of Charleston
  • Mid-scale Highway hotel
  • Gym / Fitness Center Available
More Photos Exterior of Comfort Inn
From$80
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Drury Inn & Suites Sikeston
+1-888-305-3366

How should we direct your call?

New Reservations: +1-888-305-3366 Group Sales: +1-888-494-8863 Front Desk: 18004361126
2608 East Malone Ave., Sikeston, MO 63801 ~11.45 miles west of Charleston
  • Affordable Highway property
  • Check in: 3:00 PM
  • Good snacks
  • Great food
More Photos Exterior of Drury Inn & Suites Sikeston
From$104
Very Good 4.5 /5Recent Reviews CallBookMore Details
Super 8
+1-800-881-1523

How should we direct your call?

New Reservations: +1-800-881-1523 Group Sales: +1-888-494-8863
2609 East Malone Ave., Sikeston, MO 63801 ~11.45 miles west of Charleston
  • Two-star Convention Center hotel
  • 62 rooms in property
More Photos Exterior of Super 8
From$44
Average 3.0 /5Recent Reviews CallBookMore Details
Pear Tree Inn Sikeston
+1-888-283-3404

How should we direct your call?

New Reservations: +1-888-283-3404 Group Sales: +1-888-494-8863 Front Desk: 18003250720
2602 East Malone, Sikeston, MO 63801 ~11.45 miles west of Charleston
  • 3-star Suburban hotel
  • Hotel has 80 rooms
  • Eating places near
  • Affordable food
More Photos Image of Pear Tree Inn Sikeston
From$80
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Holiday Inn Express Sikeston
+1-866-221-8581

How should we direct your call?

New Reservations: +1-866-221-8581 Group Sales: +1-888-494-8863 Front Desk: 15734759522
115 Hospitality Dr., Sikeston, MO 63801 ~14.33 miles west of Charleston
  • Mid-scale hotel
  • Gym / Fitness Center Available
More Photos hotel room
From$99
Very Good 4.0 /5Recent Reviews CallBookMore Details
Days Inn Sikeston
+1-866-429-5787

How should we direct your call?

New Reservations: +1-866-429-5787 Group Sales: +1-888-494-8863 Front Desk: 5734713930
1330 South Main St., Sikeston, MO 63801 ~14.44 miles west of Charleston
  • Inexpensive property
  • Check in: 11:00 AM
More Photos hotel room
From$60
Poor 2.0 /5Latest Reviews CallBookMore Details
Americas Best Value Inn in Ullin
+1-888-690-5281

How should we direct your call?

New Reservations: +1-888-690-5281 Group Sales: +1-888-494-8863 Front Desk: 16188453700
128 Cheekwood Lane, Ullin, IL 62992 ~25.98 miles north of Charleston
  • Inexpensive property
  • Check-in: 15:00
More Photos Image of Americas Best Value Inn
From$60
Very Good 4.0 /5Latest Reviews CallBookMore Details
Courtyard Cape Girardeau Downtown : 400 Broadway St.
+1-888-690-5247

How should we direct your call?

New Reservations: +1-888-690-5247 Group Sales: +1-888-494-8863 Front Desk: 15732409420
400 Broadway St., Cape Girardeau, MO 63701 ~28.56 miles north of Charleston
  • Affordable Downtown hotel
  • Fitness center on property
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From$80
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Candlewood Suites Cape Girardeau - Cape Girardeau
+1-888-305-3366

How should we direct your call?

New Reservations: +1-888-305-3366 Group Sales: +1-888-494-8863 Front Desk: 15733346868
485 South Mount Auburn Rd., Cape Girardeau, MO 65703 ~28.61 miles northwest of Charleston
  • Cheap Highway property
  • 4 floors in property
More Photos Exterior of Candlewood Suites Cape Girardeau
From$62
Very Good 4.0 /5Guest Reviews CallBookMore Details
Hampton Inn Cape Girardeau I 55 East : 207 South Mt. Auburn Rd.
+1-800-881-1523

How should we direct your call?

New Reservations: +1-800-881-1523 Group Sales: +1-888-494-8863 Front Desk: 15733344499
207 South Mt. Auburn Rd., Cape Girardeau, MO 63703 ~29.29 miles northwest of Charleston
  • 3-star property
  • 4 floors in hotel
More Photos Image of Hampton Inn Cape Girardeau I 55 East
From$69
Excellent 5.0 /5Read Reviews CallBookMore Details
Auburn Place Hotel & Suites in Cape Girardeau
+1-888-283-3404

How should we direct your call?

New Reservations: +1-888-283-3404 Group Sales: +1-888-494-8863 Front Desk: 15736514486
3265 Williams St., Cape Girardeau, MO 63702 ~29.41 miles northwest of Charleston
  • Mid-scale Highway property
  • Comp. Breakfast
  • Clean facility
  • Comfortable beds
More Photos Exterior of Auburn Place Hotel & Suites
From$65
Very Good 4.5 /5Reviews CallBookMore Details
Holiday Inn Express & Suites Cape Girardeau I 55 in Cape Girardeau
+1-866-221-8581

How should we direct your call?

New Reservations: +1-866-221-8581 Group Sales: +1-888-494-8863
3253 William St., Cape Girardeau, MO 63701 ~29.43 miles northwest of Charleston
  • 2-star property
  • Check in time: 11:00
More Photos Photo of Holiday Inn Express & Suites Cape Girardeau I 55
From$60
Very Good 4.5 /5Guest Reviews CallBookMore Details
Pear Tree Inn Cape Girardeau West
+1-866-429-5787

How should we direct your call?

New Reservations: +1-866-429-5787 Group Sales: +1-888-494-8863 Front Desk: 18004361126
103 Cape West Pkwy., Cape Girardeau, MO 63701 ~29.49 miles northwest of Charleston
  • Cheap hotel
  • 3 floors in property
More Photos Exterior of Pear Tree Inn Cape Girardeau West
From$60
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Pear Tree Inn Cape Girardeau Medical Center - Cape Girardeau
+1-888-690-5281

How should we direct your call?

New Reservations: +1-888-690-5281 Group Sales: +1-888-494-8863 Front Desk: 18004361126
3248 William St., Cape Girardeau, MO 63701 ~29.50 miles northwest of Charleston
  • 2 star Highway hotel
  • 78 rooms in property
  • Good continental breakfast
  • Good value for the money
More Photos Photo of Pear Tree Inn Cape Girardeau Medical Center
From$66
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Drury Suites Cape Girardeau
+1-888-690-5247

How should we direct your call?

New Reservations: +1-888-690-5247 Group Sales: +1-888-494-8863 Front Desk: 18004361126
3303 Campster Dr., Cape Girardeau, MO 63701 ~29.60 miles northwest of Charleston
  • Three Star Highway hotel
  • Hotel has a green policy See policy
  • Free dinner
  • Nice rooms
More Photos Image of Drury Suites Cape Girardeau
From$89
Very Good 4.5 /5Guest Reviews CallBookMore Details
Drury Lodge Cape Girardeau
+1-888-305-3366

How should we direct your call?

New Reservations: +1-888-305-3366 Group Sales: +1-888-494-8863 Front Desk: 18004361169
104 South Vantage Dr., Cape Girardeau, MO 63701 ~29.76 miles northwest of Charleston
  • Mid-scale Highway hotel
  • Free breakfast
  • Elevator in need of updating
  • Most guests were happy with the price of the breakfast
More Photos Photo of Drury Lodge Cape Girardeau
From$89
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Drury Plaza Hotel & Conference Center Cape Girardeau in Cape Girardeau
+1-800-881-1523

How should we direct your call?

New Reservations: +1-800-881-1523 Group Sales: +1-888-494-8863 Front Desk: 15733347151
3351 Percy Dr., Cape Girardeau, MO 63701 ~29.79 miles northwest of Charleston
  • 3-star hotel
  • 52 suites in hotel
More Photos Photo of Drury Plaza Hotel & Conference Center Cape Girardeau
From$80
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Travelodge in Marston
+1-888-283-3404

How should we direct your call?

New Reservations: +1-888-283-3404 Group Sales: +1-888-494-8863 Front Desk: 15736430075
301 Route Ad, Marston, MO 63866 ~31.28 miles southwest of Charleston
  • 2-star Highway property
  • 60 rooms in hotel
More Photos Image of Travelodge
From$40
Poor 2.5 /5Reviews CallBookMore Details
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