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Cairo Illinois Accommodations

Find hotels & motels in Cairo using the list below. Search for cheap and discounted hotel and motel rates in or close to Cairo, IL for your upcoming individual or group travel. Discover the best Cairo Illinois hotel/motel rooms. Review the Cairo hotel list below to find the perfect lodging. We also have a map of the Cairo hotels.

Cairo Hotels/Accommodations

Quality Inn Cairo I-57 13201 Kessler Rd., Cairo, IL 62914
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  • Affordable Highway property
  • Check in time: 3 pm
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From$60
Poor 2.0 /5 Hotel Reviews Call BookMore Details
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Super 8 by Wyndham Charleston/Sikeston East MO - Charleston 310 South Story, Charleston, MO 63834
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~10.13 miles southwest of Cairo
  • Inexpensive Highway hotel
  • 7 suites in hotel
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From$42
Average 3.5 /5 Reviews Call BookMore Details
Quality Inn Charleston - Sikeston - Charleston 102 Drake St., Charleston, MO 63834
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~11.88 miles southwest of Cairo
  • Economical Highway hotel
  • 9 suites in hotel
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From$59
Average 3.0 /5 Guest Reviews Call BookMore Details
Americas Best Value Inn Ullin Mounds 128 Cheekwood Lane, Ullin, IL 62992
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~17.88 miles north of Cairo
  • Cheap hotel
  • 40 rooms in property
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From$60
Average 3.0 /5 Reviews Call BookMore Details
Motel 6 Sikeston Mo in SIKESTON 110 South Interstate Dr., SIKESTON, MO 63801
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~20.96 miles west of Cairo
  • Low Cost property
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From$60
Average 3.0 /5 Recent Reviews Call BookMore Details
Best Western Plus Sikeston 120 South Interstate Dr., Sikeston, MO 63801
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~21.00 miles west of Cairo
  • Cheap Highway hotel
  • 55 rooms in hotel
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From$43
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Days Inn and Suites by Wyndham Sikeston in Sikeston 220 South Interstate Dr., Sikeston, MO 63801
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~21.07 miles west of Cairo
  • Cheap property
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From$60
Average 3.0 /5 Review Score Call BookMore Details
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) 100 Matthews Lane, Sikeston, MO 63801
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~21.31 miles west of Cairo
  • Mid-scale Highway hotel
  • 2 floors in property
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From$80
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Super 8 by Wyndham Sikeston/Miner Area 2609 East Malone, Sikeston, MO 63801
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~21.32 miles west of Cairo
  • Cheap Convention Center property
  • Check-in time: 01:00
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From$60
Average 3.0 /5 Hotel Reviews Call BookMore Details
Comfort Inn 109 Matthews Lane, Sikeston, MO 63801
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~21.34 miles west of Cairo
  • 3 star Highway hotel
  • Fitness center on property
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From$85
Average 3.0 /5 Latest Reviews Call BookMore Details
Hampton Inn Sikeston - Sikeston 1240 Commerce Dr., Sikeston, MO 63801
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~24.48 miles west of Cairo
  • Affordable Rural hotel
  • Free breakfast available
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From$80
Average 3.0 /5 Latest Reviews Call BookMore Details
Holiday Inn Express & Suites Sikeston An Ihg Hotel 115 Hospitality Dr., Sikeston, MO 63801
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~24.49 miles west of Cairo
  • Three Star Rural hotel
  • 3 floors in property
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From$80
Average 3.0 /5 Recent Reviews Call BookMore Details
Residence Inn by Marriott Paducah in Paducah 3900 Coleman Crossing Circle, Paducah, KY 42001
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~25.66 miles east of Cairo
  • Three Star Suburban hotel
  • Fitness / Gym is on-site
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From$89
Very Good 4.0 /5 Recent Reviews Call BookMore Details
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Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destinatio in Metropolis 100 East Front St., Metropolis, IL 62960
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~26.28 miles east of Cairo
  • High-end property
  • Check in: 16:00
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From$160
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Baymont by Wyndham Metropolis in Metropolis 203 East Front St., Metropolis, IL 62960
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~26.32 miles east of Cairo
  • Two star Riverfront property
  • 8 suites in hotel
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From$45
Average 3.0 /5 Read Reviews Call BookMore Details
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Econo Lodge 1415 East 5th St., Metropolis, IL 62960
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~27.38 miles east of Cairo
  • Economy property
  • 45 sleeping rooms in hotel
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From$60
Not Good 1.0 /5 Read Reviews Call BookMore Details
 Econo Lodge Paducah West I-24 - Paducah 5120 Hinkleville Rd., Paducah, KY 42001
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~27.55 miles east of Cairo
  • Inexpensive Airport hotel
  • Hotel has 2 floors
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From$60
Average 3.0 /5 Read Reviews Call BookMore Details
Baymont by Wyndham Paducah : 5300 Old Cairo Rd. 5300 Old Cairo Rd., Paducah, KY 42001
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~27.64 miles east of Cairo
  • 3-star property
  • 74 sleeping rooms in hotel
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From$40
Poor 2.0 /5 Hotel Reviews Call BookMore Details
Courtyard by Marriott Cape Girardeau Downtown 400 Broadway St., Cape Girardeau, MO 63701
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~27.65 miles northwest of Cairo
  • Mid-scale Downtown property
  • 78 sleeping rooms in hotel
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From$80
Very Good 4.0 /5 Reviews Call BookMore Details
Drury Suites Paducah 2930 James Sanders Blvd., Paducah, KY 42001
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~27.70 miles east of Cairo
  • 3 star Suburban property
  • Check in: 3:00 PM
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From$99
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Quality Suites Paducah I-24 : 2880 James Sanders Blvd. 2880 James Sanders Blvd., Paducah, KY 42001 Website
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~27.73 miles east of Cairo
  • Two-star Highway property
  • Hotel has an eco-friendly policy Learn more
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From$60
Average 3.0 /5 Latest Reviews Call BookMore Details
Comfort Inn & Suites near Six Flags in Lithia Springs 960 West Pointe Court, Lithia Springs, GA 30122 Website
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~27.80 miles east of Cairo
  • 3 star Downtown property
  • Comp. Breakfast
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From$70
Very Good 4.0 /5 Read Reviews Call BookMore Details
Garner Hotel Paducah West by IHG 145 Mcbride Lane, Paducah, KY 42001
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~27.80 miles east of Cairo
  • Affordable Highway hotel
  • Free breakfast
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From$49
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Hotel 7 Inn Paducah 5001 Hinkleville Rd., Paducah, KY 42001
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~27.81 miles east of Cairo
  • Inexpensive hotel
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From$60
Average 3.0 /5 Latest Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham Paducah : 3960 Coleman Crossing Cir 3960 Coleman Crossing Cir, Paducah, KY 42001
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~27.90 miles east of Cairo
  • 3 star Highway property
  • Comp. Breakfast
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From$80
Average 3.0 /5 Review Score Call BookMore Details
Candlewood Suites Paducah by IHG in Paducah 3940 Coleman Crossing Circle, Paducah, KY 42001
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~27.91 miles east of Cairo
  • 3-star Rural property
  • 4 floors in hotel
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From$60
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Homewood Suites by Hilton Paducah in Paducah 3925 Coleman Crossing Cir, Paducah, KY 42001
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~27.94 miles east of Cairo
  • Three Star Highway hotel
  • Hotel has 97 suites
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From$109
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Comfort Suites 3918 Coleman Crossing Cir Paducah Ky 42001, Paducah, KY 42001
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~27.96 miles east of Cairo
  • Inexpensive Rural hotel
  • 72 suites in property
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From$60
Average 3.0 /5 Review Score Call BookMore Details
Comfort Inn Paducah in Paducah 5135 Cairo Rd., Paducah, KY 42001
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~27.98 miles east of Cairo
  • Affordable property
  • Free breakfast
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From$59
Very Good 4.0 /5 Reviews Call BookMore Details
Fairfield Inn & Suites by Marriott Paducah 3950 Coleman Crossing Circle, Paducah, KY 42001
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~28.01 miles east of Cairo
  • 3 star Rural property
  • Free complimentary breakfast
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From$75
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Red Roof Inn Paducah 5106 Old Cairo Rd., Paducah, KY 42001
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~28.01 miles east of Cairo
  • Inexpensive property
  • Hotel has 8 suites
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From$45
Average 3.5 /5 Guest Reviews Call BookMore Details
American Inn - Paducah 5125 Cairo Rd., Paducah, KY 42001
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~28.02 miles east of Cairo
  • Two star property
  • 37 rooms in property
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From$37
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Hampton Inn & Suites Paducah 3901 Coleman Crossing Circle, Paducah, KY 42001
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~28.02 miles east of Cairo
  • 3-star Highway hotel
  • Complimentary breakfast is offered
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From$79
Very Good 4.5 /5 Review Score Call BookMore Details
Holiday Inn Express Hotel & Suites Paducah West by IHG 3996 Hinkleville Rd., Paducah, KY 42001
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~28.04 miles east of Cairo
  • Mid-scale Highway property
  • 3 floors in hotel
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From$80
Average 3.0 /5 Hotel Reviews Call BookMore Details
Auburn Place Hotel & Suites - Paducah in Paducah 3994 Hinkleville Rd., Paducah, KY 42001
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~28.05 miles east of Cairo
  • 3-star Airport hotel
  • 76 suites in hotel
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From$80
Very Good 4.0 /5 Read Reviews Call BookMore Details
Courtyard by Marriott Paducah in Paducah 3835 Technology Dr., Paducah, KY 42001
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~28.29 miles east of Cairo
  • Midscale Suburban property
  • 3 floors in property
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From$89
Very Good 4.0 /5 Read Reviews Call BookMore Details
Days Inn by Wyndham Paducah I-24 Exit 4 3901 Hinkleville Rd., Paducah, KY 42001
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~28.75 miles east of Cairo
  • Low priced Highway property
  • 122 rooms in hotel
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From$50
Average 3.0 /5 Recent Reviews Call BookMore Details
Candlewood Suites Cape Girardeau by IHG in Cape Girardeau 485 South Mount Auburn Rd., Cape Girardeau, MO 65703
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~28.76 miles northwest of Cairo
  • 2-star Highway hotel
  • Hotel has 85 suites
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From$69
Very Good 4.0 /5 Read Reviews Call BookMore Details
Travelers Inn and Suites : 2550 Lone Oak Rd. 2550 Lone Oak Rd., Paducah, KY 42003
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~28.88 miles east of Cairo
  • 2-star hotel
  • 2 floors in hotel
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From$38
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Quality Inn & Suites Metropolis I-24 2118 East 5th St., Metropolis, IL 62960
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~28.88 miles east of Cairo
  • Three Star property
  • Check-in: 11:00
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From$80
Very Good 4.0 /5 Read Reviews Call BookMore Details
Super 8 by Wyndham Metropolis : 2055 East 5th St. 2055 East 5th St., Metropolis, IL 62960
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~28.89 miles east of Cairo
  • Low priced Highway property
  • 6 suites in hotel
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From$60
Average 3.0 /5 Read Reviews Call BookMore Details
Motel 6 Metropolis Il - Metropolis 2119 East 5th St., Metropolis, IL 62960
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~29.04 miles east of Cairo
  • Low-priced hotel
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From$60
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Holiday Inn Express Metropolis by IHG 2179 East 5th St., Metropolis, IL 62960
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~29.10 miles east of Cairo
  • Affordable Rural property
  • Access to gym on-site
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From$65
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Hampton Inn Cape Girardeau I 55 East 207 South Mount Auburn Rd., Cape Girardeau, MO 63703
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~29.41 miles northwest of Cairo
  • 3-star Highway hotel
  • Hotel has 86 rooms
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From$80
Excellent 5.0 /5 Reviews Call BookMore Details
Victorian Inn & Suites : 3256 William St. 3256 William St., Cape Girardeau, MO 63703
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~29.41 miles northwest of Cairo
  • Affordable Golf Course property
  • Free breakfast available
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From$79
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Auburn Place Hotel & Suites - Cape Girardeau 3265 Williams St., Cape Girardeau, MO 63702
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~29.42 miles northwest of Cairo
  • Midscale Highway property
  • Hotel has 133 rooms
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From$58
Very Good 4.5 /5 Recent Reviews Call BookMore Details
Holiday Inn Express & Suites Cape Girardeau I 55 by Ihg 3253 William St., Cape Girardeau, MO 63701
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~29.49 miles northwest of Cairo
  • Three Star property
  • 102 suites in property
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From$80
Very Good 4.5 /5 Recent Reviews Call BookMore Details
Fairfield Inn & Suites Cape Girardeau : 433 Cape West Crossing 433 Cape West Crossing, Cape Girardeay, MO 63703
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~29.58 miles northwest of Cairo
  • 3 star hotel
  • 4 floors in property
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From$80
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Drury Suites Cape Girardeau 3303 Campster Dr., Cape Girardeau, MO 63701
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~29.72 miles northwest of Cairo
  • 3-star Highway property
  • 79 suites in property
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From$85
Very Good 4.5 /5 Recent Reviews Call BookMore Details
Drury Lodge - Cape Girardeau 104 South Vantage Dr., Cape Girardeau, MO 63701
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~29.82 miles northwest of Cairo
  • Midscale Highway property
  • Check in: 3:00pm
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From$80
Average 3.0 /5 Latest Reviews Call BookMore Details

Next: See My Cairo Hotels with Pricing

Graph: Upcoming 20 Days of Cairo Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Cairo, IL discounts available. The chart reflects the cheapest Cairo hotel for each day and each star rating category.

FAQs about hotels in Cairo

What are the most favored hotels in Cairo?

Hampton Inn Cape Girardeau I 55 East, Hampton Inn & Suites Paducah and Auburn Place Hotel & Suites are the best rated hotels based on customer reviews in the last 365 days.

What are the most luxurious hotels in Cairo?

Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destinatio, Quality Inn Cairo I-57 and Travel Inn & Suites - Sikeston are the top 3 luxury hotels near Cairo city center.

What hotels are closest to the city center of Cairo?

Quality Inn Cairo I-57, Super 8 by Wyndham Charleston, and Quality Inn Charleston - Sikeston are the properties closest to Cairo city center.

What are the best independent hotels in Cairo?

Auburn Place Hotel & Suites, Drury Suites Cape Girardeau and Travel Inn & Suites - Sikeston are the best rated independent hotels (not part of a big brand).

What are the most popular Marriott hotels in Cairo?

Residence Inn by Marriott Paducah, Courtyard by Marriott Cape Girardeau Downtown and Fairfield Inn & Suites by Marriott Paducah are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the best Choice Hotels branded hotels in Cairo?

Comfort Inn & Suites near Six Flags, Comfort Inn Paducah and Quality Inn & Suites Metropolis I-24 are the best rated Choice Hotels branded hotels (based on HotelPlanner reviews score).

What are the best IHG hotels in Cairo?

Holiday Inn Express & Suites Cape Girardeau I 55 by Ihg, Candlewood Suites Paducah by IHG and Candlewood Suites Cape Girardeau by IHG are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

Verified reviews of the city: Cairo, IL

Below are reviews of the city of Cairo, IL from an actual visitor's perspective.

"Spending time with my family"
Score 5.0 / 5

Vincent R., from 26-Jan-2026
The average traveler rating of the city of Cairo, IL shown above is 5.0 out of 5 based on 1 reviews
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