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Cairo Illinois Accommodations

Find hotels & motels in Cairo using the list below. Search for cheap and discounted hotel and motel rates in or close to Cairo, IL for your upcoming individual or group travel. Discover the best Cairo Illinois hotel/motel rooms. Review the Cairo hotel list below to find the perfect lodging. We also have a map of the Cairo hotels.

Cairo Hotels, Motels & Accommodations

Quality Inn Cairo I-57
+1-888-389-4121
13201 Kessler Rd., Cairo, IL 62914
  • Affordable Highway property
  • Check-in: 3 pm
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Super 8 by Wyndham Charleston/Sikeston East MO
+1-888-675-2083
310 South Story, Charleston, MO 63834 ~10.14 miles southwest of Cairo
  • Two star Highway hotel
  • Free complimentary breakfast
From$42
Average 3.5 /5 Review Score Call BookMore Details
Quality Inn Charleston - Sikeston
+1-800-716-8490
102 Drake St., Charleston, MO 63834 ~11.90 miles southwest of Cairo
  • 2 star Highway property
  • Check-in: 3:00PM
From$59
Average 3.0 /5 Recent Reviews Call BookMore Details
Americas Best Value Inn Ullin Mounds
+1-800-805-5223
128 Cheekwood Lane, Ullin, IL 62992 ~17.90 miles north of Cairo
  • Two star hotel
  • Check-in time: 15:00
From$60
Average 3.0 /5 Hotel Reviews Call BookMore Details
Motel 6 Sikeston Mo
+1-888-965-1860
110 South Interstate Dr., SIKESTON, MO 63801 ~21.01 miles west of Cairo
  • Inexpensive property
From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
Best Western Plus Sikeston in Sikeston
+1-888-788-5576
120 South Interstate Dr., Sikeston, MO 63801 ~21.04 miles west of Cairo
  • Low priced Highway hotel
  • Check-in: 03:00
From$43
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Days Inn and Suites by Wyndham Sikeston
+1-888-897-9207
220 South Interstate Dr., Sikeston, MO 63801 ~21.11 miles west of Cairo
  • Economical hotel
  • Fitness + Health Center
From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) - Sikeston
+1-888-311-4278
100 Matthews Lane, Sikeston, MO 63801 ~21.35 miles west of Cairo
  • Affordable Highway hotel
  • Hotel has 2 floors
From$80
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Super 8 by Wyndham Sikeston/Miner Area
+1-888-469-4795
2609 East Malone, Sikeston, MO 63801 ~21.37 miles west of Cairo
  • Low-priced Convention Center property
  • Check in: 01:00
From$60
Average 3.0 /5 Hotel Reviews Call BookMore Details
Comfort Inn in Sikeston
+1-888-734-9421
109 Matthews Lane, Sikeston, MO 63801 ~21.39 miles west of Cairo
  • Mid-scale Highway property
  • Hotel has 64 rooms
From$85
Average 3.0 /5 Recent Reviews Call BookMore Details
Drury Inn & Suites Sikeston : 2608 East Malone Ave.
+1-888-841-5292
2608 East Malone Ave., Sikeston, MO 63801 ~21.42 miles west of Cairo
  • Three Star Highway property
  • Check in time: 3:00 PM
From$104
Very Good 4.5 /5 Hotel Reviews Call BookMore Details
Pear Tree Inn Sikeston - Sikeston
+1-888-455-5160
2602 East Malone, Sikeston, MO 63801 ~21.42 miles west of Cairo
  • 3 star Suburban property
  • Check in time: 3:00 PM
From$80
Average 3.0 /5 Latest Reviews Call BookMore Details
Hampton Inn Sikeston
+1-888-965-8297
1240 Commerce Dr., Sikeston, MO 63801 ~24.53 miles west of Cairo
  • Midscale Rural property
  • 4 floors in property
From$80
Average 3.0 /5 Hotel Reviews Call BookMore Details
Holiday Inn Express & Suites Sikeston An Ihg Hotel in Sikeston
+1-888-906-6358
115 Hospitality Dr., Sikeston, MO 63801 ~24.55 miles west of Cairo
  • Midscale Rural property
  • Hotel has 3 floors
From$80
Average 3.0 /5 Review Score Call BookMore Details
Residence Inn by Marriott Paducah
+1-888-749-6785
3900 Coleman Crossing Circle, Paducah, KY 42001 ~25.70 miles east of Cairo
  • 3-star Suburban hotel
  • Gym / Fitness Center Available
From$89
Very Good 4.0 /5 Reviews Call BookMore Details
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Pear Tree Inn Paducah : 5006 Hinkleville Rd.
+1-888-878-9982
5006 Hinkleville Rd., Paducah, KY 42001 ~25.80 miles east of Cairo
  • Inexpensive Suburban hotel
  • 2 floors in property
From$55
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Harrah's Metropolis Hotel & Casino - Metropolis
+1-888-389-4485
100 East Front St., Metropolis, IL 62960 ~26.30 miles east of Cairo
  • Four-star property
  • 12 suites in property
From$160
Very Good 4.0 /5 Reviews Call BookMore Details
Baymont by Wyndham Metropolis : 203 East Front St.
+1-888-389-4121
203 East Front St., Metropolis, IL 62960 ~26.33 miles east of Cairo
  • Economy Riverfront property
  • Comp. Breakfast
From$45
Average 3.0 /5 Reviews Call BookMore Details
Econo Lodge
+1-888-675-2083
1415 East 5th St., Metropolis, IL 62960 ~27.39 miles east of Cairo
  • Cheap hotel
  • 45 sleeping rooms in hotel
From$60
Not Good 1.0 /5 Reviews Call BookMore Details
 Econo Lodge Paducah West I-24
+1-800-716-8490
5120 Hinkleville Rd., Paducah, KY 42001 ~27.58 miles east of Cairo
  • Two star Airport property
  • Hotel has a green policy Read more
From$60
Average 3.0 /5 Latest Reviews Call BookMore Details
Courtyard by Marriott Cape Girardeau Downtown - Cape Girardeau
+1-800-805-5223
400 Broadway St., Cape Girardeau, MO 63701 ~27.66 miles northwest of Cairo
  • Midscale Downtown hotel
  • 5 floors in hotel
From$80
Very Good 4.0 /5 Reviews Call BookMore Details
Baymont by Wyndham Paducah in Paducah
+1-888-965-1860
5300 Old Cairo Rd., Paducah, KY 42001 ~27.67 miles east of Cairo
  • Mid-scale hotel
  • Hotel has 4 suites
From$40
Poor 2.0 /5 Reviews Call BookMore Details
Drury Suites Paducah
+1-888-788-5576
2930 James Sanders Blvd., Paducah, KY 42001 ~27.73 miles east of Cairo
  • Three Star Suburban hotel
  • 138 sleeping rooms in hotel
From$99
Very Good 4.0 /5 Read Reviews Call BookMore Details
Quality Suites Paducah I-24 - Paducah
+1-888-897-9207
2880 James Sanders Blvd., Paducah, KY 42001 Website ~27.76 miles east of Cairo
  • Two star Highway hotel
  • Access to gym on-site
From$60
Average 3.0 /5 Read Reviews Call BookMore Details
Country Inn & Suites by Radisson, Paducah, KY
+1-888-311-4278
145 Mcbride Lane, Paducah, KY 42001 ~27.83 miles east of Cairo
  • 3 star Highway property
  • Hotel has 17 suites
From$49
Very Good 4.0 /5 Reviews Call BookMore Details
Comfort Inn & Suites near Six Flags
+1-888-469-4795
960 West Pointe Court, Lithia Springs, GA 30122 Website ~27.83 miles east of Cairo
  • Midscale Downtown property
  • 2 floors in property
From$70
Very Good 4.0 /5 Review Score Call BookMore Details
Hotel 7 Inn Paducah - Paducah
+1-888-734-9421
5001 Hinkleville Rd., Paducah, KY 42001 ~27.84 miles east of Cairo
  • Cheap hotel
From$60
Average 3.0 /5 Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham Paducah : 3960 Coleman Crossing Cir
+1-888-841-5292
3960 Coleman Crossing Cir, Paducah, KY 42001 ~27.93 miles east of Cairo
  • 3-star Highway hotel
  • 26 suites in hotel
From$80
Average 3.0 /5 Latest Reviews Call BookMore Details
Candlewood Suites Paducah by IHG
+1-888-455-5160
3940 Coleman Crossing Circle, Paducah, KY 42001 ~27.94 miles east of Cairo
  • Three Star Rural property
  • 85 rooms in property
From$60
Very Good 4.0 /5 Reviews Call BookMore Details
Homewood Suites by Hilton Paducah in Paducah
+1-888-965-8297
3925 Coleman Crossing Cir, Paducah, KY 42001 ~27.97 miles east of Cairo
  • 3 star Highway hotel
  • Gym / Fitness Center Available
From$109
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Comfort Suites : 3918 Coleman Crossing Cir Paducah Ky 42001
+1-888-906-6358
3918 Coleman Crossing Cir Paducah Ky 42001, Paducah, KY 42001 ~27.99 miles east of Cairo
  • Economy Rural property
  • Hotel has 4 floors
From$60
Average 3.0 /5 Recent Reviews Call BookMore Details
Comfort Inn Paducah : 5135 Cairo Rd.
+1-888-749-6785
5135 Cairo Rd., Paducah, KY 42001 ~28.01 miles east of Cairo
  • Mid-scale hotel
  • 64 suites in hotel
From$59
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Fairfield Inn & Suites by Marriott Paducah in Paducah
+1-888-878-9982
3950 Coleman Crossing Circle, Paducah, KY 42001 ~28.03 miles east of Cairo
  • Mid-scale Rural hotel
  • Check in: 3:00 pm
From$75
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Red Roof Inn Paducah
+1-888-389-4485
5106 Old Cairo Rd., Paducah, KY 42001 ~28.04 miles east of Cairo
  • Two-star hotel
  • 40 rooms in hotel
From$45
Average 3.5 /5 Recent Reviews Call BookMore Details
American Inn - Paducah
+1-888-389-4121
5125 Cairo Rd., Paducah, KY 42001 ~28.05 miles east of Cairo
  • Two-star property
  • Comp. Breakfast
From$37
Very Good 4.0 /5 Review Score Call BookMore Details
Holiday Inn Express Hotel & Suites Paducah West by IHG - Paducah
+1-888-675-2083
3996 Hinkleville Rd., Paducah, KY 42001 ~28.07 miles east of Cairo
  • 3 star Highway hotel
  • Comp. Breakfast
From$80
Average 3.0 /5 Recent Reviews Call BookMore Details
Auburn Place Hotel & Suites - Paducah
+1-800-716-8490
3994 Hinkleville Rd., Paducah, KY 42001 ~28.08 miles east of Cairo
  • Three Star Airport property
  • Free comp. breakfast
From$80
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Courtyard by Marriott Paducah
+1-800-805-5223
3835 Technology Dr., Paducah, KY 42001 ~28.32 miles east of Cairo
  • Three Star Suburban property
  • 100 sleeping rooms in hotel
From$89
Very Good 4.0 /5 Review Score Call BookMore Details
Drury Inn Paducah - Paducah
+1-888-965-1860
3975 Hinkleville Rd., Paducah, KY 42001 ~28.73 miles east of Cairo
  • Midscale Suburban property
  • 5 floors in property
From$79
Very Good 4.5 /5 Hotel Reviews Call BookMore Details
Candlewood Suites Cape Girardeau by IHG in Cape Girardeau
+1-888-788-5576
485 South Mount Auburn Rd., Cape Girardeau, MO 65703 ~28.78 miles northwest of Cairo
  • Low-priced Highway hotel
  • 85 suites in property
From$69
Very Good 4.0 /5 Review Score Call BookMore Details
Days Inn by Wyndham Paducah I-24 Exit 4 in Paducah
+1-888-897-9207
3901 Hinkleville Rd., Paducah, KY 42001 ~28.78 miles east of Cairo
  • Low-priced Highway property
  • Hotel has 2 floors
From$50
Average 3.0 /5 Review Score Call BookMore Details
Quality Inn & Suites Metropolis I-24
+1-888-311-4278
2118 East 5th St., Metropolis, IL 62960 ~28.90 miles east of Cairo
  • Midscale property
  • Check in time: 11:00
From$80
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Super 8 by Wyndham Metropolis : 2055 East 5th St.
+1-888-469-4795
2055 East 5th St., Metropolis, IL 62960 ~28.91 miles east of Cairo
  • Two star Highway property
  • Free breakfast available
From$60
Average 3.0 /5 Read Reviews Call BookMore Details
Travelers Inn and Suites
+1-888-734-9421
2550 Lone Oak Rd., Paducah, KY 42003 ~28.91 miles east of Cairo
  • Low-priced property
  • 2 floors in property
From$38
Very Good 4.0 /5 Read Reviews Call BookMore Details
Motel 6 Metropolis Il
+1-888-841-5292
2119 East 5th St., Metropolis, IL 62960 ~29.06 miles east of Cairo
  • Low priced property
  • Check in time: 11:00 AM
From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
Holiday Inn Express Metropolis by IHG in Metropolis
+1-888-455-5160
2179 East 5th St., Metropolis, IL 62960 ~29.12 miles east of Cairo
  • Three Star Rural hotel
  • Has environment-friendly policy See policy
From$65
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Hampton Inn Cape Girardeau I 55 East in Cape Girardeau
+1-888-965-8297
207 South Mount Auburn Rd., Cape Girardeau, MO 63703 ~29.42 miles northwest of Cairo
  • Mid-scale Highway hotel
  • Check-in time: 15:00
From$80
Excellent 5.0 /5 Reviews Call BookMore Details
Victorian Inn & Suites - Cape Girardeau
+1-888-906-6358
3256 William St., Cape Girardeau, MO 63703 ~29.43 miles northwest of Cairo
  • Affordable Golf Course property
  • Free breakfast
From$79
Average 3.0 /5 Reviews Call BookMore Details
Auburn Place Hotel & Suites - Cape Girardeau
+1-888-749-6785
3265 Williams St., Cape Girardeau, MO 63702 ~29.44 miles northwest of Cairo
  • 3 star Highway hotel
  • Check in: 0300 pm
From$58
Very Good 4.5 /5 Reviews Call BookMore Details
Holiday Inn Express & Suites Cape Girardeau I 55
+1-888-878-9982
3253 William St., Cape Girardeau, MO 63701 ~29.51 miles northwest of Cairo
  • 3-star property
  • 102 sleeping rooms in hotel
From$80
Very Good 4.5 /5 Hotel Reviews Call BookMore Details

Next: See My Cairo Hotels with Pricing

Graph: Upcoming 20 Days of Cairo Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Cairo, IL discounts available. The chart reflects the cheapest Cairo hotel for each day and each star rating category.

FAQs about hotels in Cairo

What are the most favored hotels in Cairo?

Hampton Inn Cape Girardeau I 55 East, Drury Inn & Suites Sikeston and Drury Inn Paducah are the best rated hotels based on customer reviews in the last 365 days.

What are the most luxurious hotels in Cairo?

Harrah's Metropolis Hotel & Casino, Quality Inn Cairo I-57 and Travel Inn & Suites - Sikeston are the top 3 luxury hotels near Cairo city center.

What hotels are closest to the city center of Cairo?

Quality Inn Cairo I-57, Super 8 by Wyndham Charleston, and Quality Inn Charleston - Sikeston are the properties closest to Cairo city center.

What are the best independent hotels in Cairo?

Auburn Place Hotel & Suites, Travel Inn & Suites - Sikeston and Harrah's Metropolis Hotel & Casino are the best rated independent hotels (not part of a big brand).

What are the most popular Marriott hotels in Cairo?

Residence Inn by Marriott Paducah, Courtyard by Marriott Cape Girardeau Downtown and Fairfield Inn & Suites by Marriott Paducah are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the best Choice Hotels branded hotels in Cairo?

Comfort Inn & Suites near Six Flags, Comfort Inn Paducah and Quality Inn & Suites Metropolis I-24 are the best rated Choice Hotels branded hotels (based on HotelPlanner reviews score).

What are the best IHG hotels in Cairo?

Holiday Inn Express & Suites Cape Girardeau I 55, Candlewood Suites Paducah by IHG and Candlewood Suites Cape Girardeau by IHG are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

Verified reviews of the city: Cairo, IL

Below are reviews of the city of Cairo, IL from an actual visitor's perspective.

""
Score 5.0 / 5

Family

Beverly T., from 10-Mar-2025
""
Score 4.0 / 5

Family

Beverly T., from 10-Mar-2025
The average traveler rating of the city of Cairo, IL shown above is 4.5 out of 5 based on 2 reviews
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