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Cairo Illinois Accommodations

Find hotels & motels in Cairo using the list below. Search for cheap and discounted hotel and motel rates in or close to Cairo, IL for your upcoming individual or group travel. Discover the best Cairo Illinois hotel/motel rooms. Review the Cairo hotel list below to find the perfect lodging. We also have a map of the Cairo hotels.

Cairo Hotels/Accommodations

Quality Inn Cairo I-57 in Cairo
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
13201 Kessler Rd., Cairo, IL 62914
  • Mid-scale Highway property
  • Check-in time: 3 pm
  • Bed was comfortable
  • Disappointing food
More PhotosPhoto of Quality Inn Cairo I-57
From$60
Average 3.0 /5Hotel Reviews CallBookMore Details
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Super 8 by Wyndham Charleston MO in Charleston
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
310 South Story, Charleston, MO 63834 ~10.14 miles southwest of Cairo
  • 2-star Highway hotel
  • Hotel has 60 rooms
More PhotosPhoto of Super 8 by Wyndham Charleston MO
From$42
Average 3.5 /5Read Reviews CallBookMore Details
Quality Inn : 102 Drake St.
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
102 Drake St., Charleston, MO 63834 ~11.90 miles southwest of Cairo
  • Cheap Highway property
  • Check in time: 3:00PM
More PhotosPhoto of Quality Inn
From$59
Average 3.0 /5Reviews CallBookMore Details
Americas Best Value Inn Ullin Mounds
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
128 Cheekwood Lane, Ullin, IL 62992 ~17.90 miles north of Cairo
  • Cheap hotel
  • Check-in: 15:00
More PhotosExterior of Americas Best Value Inn Ullin Mounds
From$60
Very Good 4.0 /5Reviews CallBookMore Details
Motel 6 Sikeston Mo #4328 in SIKESTON
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
110 South Interstate Dr., SIKESTON, MISSOURI 63801 ~21.01 miles west of Cairo
  • Low priced property
More PhotosExterior of Motel 6 Sikeston Mo #4328
From$60
Average 3.0 /5Recent Reviews CallBookMore Details
Best Western Plus Sikeston : 120 South Interstate Dr.
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
120 South Interstate Dr., Sikeston, MO 63801 ~21.04 miles west of Cairo
  • Cheap Highway property
  • Hotel has an eco-friendly policy Learn more
More PhotosImage of Best Western Plus Sikeston
From$42
Very Good 4.0 /5Recent Reviews CallBookMore Details
Days Inn and Suites by Wyndham Sikeston
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
220 South Interstate Dr., Sikeston, MO 63801 ~21.11 miles west of Cairo
  • Two-star hotel
  • Check-in time: 03:00 PM
More PhotosExterior of Days Inn and Suites by Wyndham Sikeston
From$60
Average 3.0 /5Guest Reviews CallBookMore Details
Drury Inn & Suites Sikeston - Sikeston
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
2608 East Malone Ave., Sikeston, MO 63801 ~21.28 miles west of Cairo
  • Three Star Highway hotel
  • Gym is available on property
More PhotosImage of Drury Inn & Suites Sikeston
From$80
Average 3.0 /5Reviews CallBookMore Details
Travel Inn & Suites
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
100 Matthews Lane, Sikeston, MO 63801 ~21.35 miles west of Cairo
  • Affordable Highway property
  • 40 rooms in hotel
  • Average hotel building
  • Breakfast can be improved
More PhotosPhoto of Travel Inn & Suites
From$80
Very Good 4.5 /5Guest Reviews CallBookMore Details
Super 8 by Wyndham Sikeston / Miner Area - Sikeston
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
2609 East Malone, Sikeston, MO 63801 ~21.37 miles west of Cairo
  • Economical Convention Center hotel
  • Check-in time: 01:00
More PhotosExterior of Super 8 by Wyndham Sikeston / Miner Area
From$60
Average 3.0 /5Review Score CallBookMore Details
Comfort Inn : 109 Matthews Lane
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
109 Matthews Lane, Sikeston, MO 63801 ~21.39 miles west of Cairo
  • Three Star Highway property
  • Check-in time: 11:00
More PhotosImage of Comfort Inn
From$85
Average 3.0 /5Recent Reviews CallBookMore Details
Pear Tree Inn Sikeston
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
2602 East Malone, Sikeston, MO 63801 ~21.42 miles west of Cairo
  • Midscale Suburban hotel
  • 4 floors in hotel
  • Desk clerk was very friendly and courteous
  • Best value for money
More PhotosImage of Pear Tree Inn Sikeston
From$80
Average 3.0 /5Read Reviews CallBookMore Details
Holiday Inn Express Sikeston in Sikeston
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
115 Hospitality Dr., Sikeston, MO 63801 ~24.55 miles west of Cairo
  • Mid-scale Rural property
  • Check-in: 15:00
More PhotosPhoto of Holiday Inn Express Sikeston
From$94
Very Good 4.0 /5Reviews CallBookMore Details
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Hampton Inn Sikeston - Sikeston
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
1240 Commerce Dr., Sikeston, MO 63801 ~24.92 miles west of Cairo
  • Three Star property
  • Gym is available on property
More PhotosImage of Hampton Inn Sikeston
From$90
Very Good 4.5 /5Latest Reviews CallBookMore Details
Residence Inn
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
3900 Coleman Crossing Circle, Paducah, KY 42001 ~25.70 miles east of Cairo
  • Three Star Suburban property
  • 74 suites in property
  • Excellent amenities
  • Clean rooms
More PhotosExterior of Residence Inn
From$89
Very Good 4.0 /5Hotel Reviews CallBookMore Details
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Pear Tree Inn Paducah : 5006 Hinkleville Rd.
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
5006 Hinkleville Rd., Paducah, KY 42001 ~25.80 miles east of Cairo
  • Economical Suburban hotel
  • Has environment-friendly policy Learn more
  • Rooms in need of an update
  • Hotel staff were very accommodating and friendly
More PhotosImage of Pear Tree Inn Paducah
From$55
Very Good 4.0 /5Hotel Reviews CallBookMore Details
Harrah's Metropolis Hotel & Casino in Metropolis
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
100 East Front St., Metropolis, IL 62960 ~26.30 miles east of Cairo
  • High end property
  • Check-in: 16:00
More PhotosExterior of Harrah's Metropolis Hotel & Casino
From$160
Very Good 4.0 /5Recent Reviews CallBookMore Details
Baymont by Wyndham Metropolis in Metropolis
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
203 East Front St., Metropolis, IL 62960 ~26.33 miles east of Cairo
  • Economical Riverfront hotel
  • Comp. Breakfast
  • Bathroom needs cleaning
  • Most guests found the staff to be very friendly
More PhotosPhoto of Baymont by Wyndham Metropolis
From$45
Average 3.0 /5Hotel Reviews CallBookMore Details
Econo Lodge : 1415 East 5th St.
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
1415 East 5th St., Metropolis, IL 62960 ~27.39 miles east of Cairo
  • Low priced property
  • 45 sleeping rooms in hotel
More Photoshotel room
From$60
Not Good 1.0 /5Hotel Reviews CallBookMore Details
Econo Lodge
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
5120 Hinkleville Rd., Paducah, KY 42001 ~27.58 miles east of Cairo
  • Economical Airport hotel
  • Hotel has 2 floors
More PhotosImage of Econo Lodge
From$60
Poor 2.0 /5Review Score CallBookMore Details
Courtyard by Marriott Cape Girardeau Downtown : 400 Broadway St.
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
400 Broadway St., Cape Girardeau, MO 63701 ~27.66 miles northwest of Cairo
  • Affordable Downtown hotel
  • Check in time: 3:00 pm
More PhotosImage of Courtyard by Marriott Cape Girardeau Downtown
From$80
Very Good 4.0 /5Latest Reviews CallBookMore Details
Baymont Inn & Suites Paducah - Paducah
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
5300 Old Cairo Rd., Paducah, KY 42001 ~27.67 miles east of Cairo
  • Three Star property
  • 3 floors in hotel
More PhotosImage of Baymont Inn & Suites Paducah
From$40
Average 3.0 /5Guest Reviews CallBookMore Details
Drury Suites Paducah
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
2930 James Sanders Blvd., Paducah, KY 42001 ~27.73 miles east of Cairo
  • 3 star Suburban property
  • Check-in: 3:00 PM
  • Affordable food
  • Suite was spacious
More PhotosPhoto of Drury Suites Paducah
From$99
Very Good 4.5 /5Review Score CallBookMore Details
Quality Suites
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
2880 James Sanders Blvd., Paducah, KY 42001 ~27.76 miles east of Cairo
  • Low-priced Highway property
  • Hotel has 59 suites
More PhotosImage of Quality Suites
From$60
Average 3.0 /5Read Reviews CallBookMore Details
Country Inn & Suites in Paducah
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
145 Mcbride Lane, Paducah, KY 42001 ~27.83 miles east of Cairo
  • Affordable Highway hotel
  • 17 suites in property
More PhotosPhoto of Country Inn & Suites
From$49
Very Good 4.0 /5Reviews CallBookMore Details
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Graph: Upcoming 20 Days of Cairo Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Cairo, IL discounts available. The chart reflects the cheapest Cairo hotel for each day and each star rating category.

FAQs about hotels in Cairo

What are the best rated hotels in Cairo?

Auburn Place Suites, Hampton Inn Cape Girardeau I 55 East and Travel Inn & Suites are the best rated hotels based on customer reviews in the last 365 days.

What are the most luxurious hotels in Cairo?

Harrah's Metropolis Hotel & Casino, Quality Inn Cairo I-57 and Drury Inn & Suites Sikeston are the top 3 luxury hotels near Cairo city center.

What hotels are closest to the city center of Cairo?

Quality Inn Cairo I-57, Super 8 by Wyndham Charleston MO, and Quality Inn are the properties closest to Cairo city center.

What are the best independent hotels in Cairo?

Auburn Place Suites, Travel Inn & Suites and Drury Suites Paducah are the best rated independent hotels (not part of a big brand).

What are the most popular Marriott hotels in Cairo?

Fairfield Inn & Suites by Marriott Paducah, Residence Inn and Courtyard by Marriott Cape Girardeau Downtown are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the most popular Choice Hotels branded hotels in Cairo?

Quality Inn & Suites Metropolis I-24, Comfort Inn Paducah and Quality Inn Cairo I-57 are the best rated Choice Hotels branded hotels (based on HotelPlanner reviews score).

What are the best IHG hotels in Cairo?

Holiday Inn Express Hotel & Suites Paducah West An Ihg Hotel, Holiday Inn Express & Suites Cape Girardeau I 55 and Holiday Inn Express Sikeston are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

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