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Cairo Illinois Accommodations

Find hotels & motels in Cairo using the list below. Search for cheap and discounted hotel and motel rates in or close to Cairo, IL for your upcoming individual or group travel. Discover the best Cairo Illinois hotel/motel rooms. Review the Cairo hotel list below to find the perfect lodging. We also have a map of the Cairo hotels.

Cairo Hotels & Accommodations

Quality Inn Cairo I-57 - Cairo 13201 Kessler Rd., Cairo, IL 62914
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  • 3-star Highway hotel
  • 2 floors in hotel
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From$60
Poor 2.0 /5 Recent Reviews Call BookMore Details
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Super 8 by Wyndham Charleston/Sikeston East MO - Charleston 310 South Story, Charleston, MO 63834
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~10.13 miles southwest of Cairo
  • Economical Highway property
  • Free breakfast
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From$42
Average 3.5 /5 Guest Reviews Call BookMore Details
The Riverstone Hotel Charleston-Sikeston in Charleston 102 Drake St., Charleston, MO 63834
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~11.88 miles southwest of Cairo
  • Inexpensive Highway property
  • Check in: 3:00PM
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From$59
Average 3.0 /5 Review Score Call BookMore Details
Americas Best Value Inn Ullin Mounds in Ullin 128 Cheekwood Lane, Ullin, IL 62992
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~17.88 miles north of Cairo
  • Low priced hotel
  • 40 rooms in hotel
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From$60
Average 3.0 /5 Read Reviews Call BookMore Details
Motel 6 Sikeston Mo 110 South Interstate Dr., SIKESTON, MO 63801
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~20.96 miles west of Cairo
  • Economy hotel
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From$60
Average 3.0 /5 Latest Reviews Call BookMore Details
Best Western Plus Sikeston I-55 : 120 South Interstate Dr. 120 South Interstate Dr., Sikeston, MO 63801
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~21.00 miles west of Cairo
  • Economy Highway hotel
  • Hotel has an eco-friendly policy See policy
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From$43
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Days Inn & Suites by Wyndham Sikeston in Sikeston 220 South Interstate Dr., Sikeston, MO 63801
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~21.07 miles west of Cairo
  • Two star property
  • Check-in: 03:00 PM
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From$60
Average 3.0 /5 Review Score Call BookMore Details
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) 100 Matthews Lane, Sikeston, MO 63801
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~21.31 miles west of Cairo
  • Midscale Highway hotel
  • Hotel has 2 floors
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From$80
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Super 8 by Wyndham Sikeston/Miner Area 2609 East Malone, Sikeston, MO 63801
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~21.32 miles west of Cairo
  • Low Cost Convention Center property
  • Check-in time: 01:00
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From$60
Average 3.0 /5 Read Reviews Call BookMore Details
Comfort Inn 109 Matthews Lane, Sikeston, MO 63801
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~21.34 miles west of Cairo
  • Affordable Highway property
  • Gym is available on property
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From$85
Average 3.0 /5 Guest Reviews Call BookMore Details
Drury Inn & Suites Sikeston in Sikeston 2608 East Malone Ave., Sikeston, MO 63801
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~21.37 miles west of Cairo
  • Mid-scale Highway property
  • Hotel has 14 suites
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From$104
Very Good 4.5 /5 Read Reviews Call BookMore Details
Pear Tree Inn Sikeston - Sikeston 2602 East Malone, Sikeston, MO 63801
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~21.38 miles west of Cairo
  • 3 star Suburban property
  • Gym is available on property
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From$80
Average 3.0 /5 Latest Reviews Call BookMore Details
Hampton Inn Sikeston in Sikeston 1240 Commerce Dr., Sikeston, MO 63801
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~24.48 miles west of Cairo
  • Mid-scale Rural hotel
  • 8 suites in hotel
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From$80
Average 3.0 /5 Reviews Call BookMore Details
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Holiday Inn Express & Suites Sikeston An Ihg Hotel in Sikeston 115 Hospitality Dr., Sikeston, MO 63801
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~24.49 miles west of Cairo
  • Mid-scale Rural hotel
  • Free comp. breakfast
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From$80
Average 3.0 /5 Hotel Reviews Call BookMore Details
Residence Inn by Marriott Paducah in Paducah 3900 Coleman Crossing Circle, Paducah, KY 42001
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~25.66 miles east of Cairo
  • Three Star Suburban property
  • Gym / Fitness Center Available
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From$89
Very Good 4.0 /5 Guest Reviews Call BookMore Details
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Pear Tree Inn Paducah 5006 Hinkleville Rd., Paducah, KY 42001
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~25.77 miles east of Cairo
  • Low Cost Suburban hotel
  • Free breakfast
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From$55
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destinatio : 100 East Front St. 100 East Front St., Metropolis, IL 62960
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~26.28 miles east of Cairo
  • Expensive hotel
  • Check in time: 16:00
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From$160
Very Good 4.0 /5 Read Reviews Call BookMore Details
Baymont by Wyndham Metropolis - Metropolis 203 East Front St., Metropolis, IL 62960
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~26.32 miles east of Cairo
  • Two-star Riverfront hotel
  • Check in time: 3:00PM
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From$45
Average 3.0 /5 Review Score Call BookMore Details
Econo Lodge - Metropolis 1415 East 5th St., Metropolis, IL 62960
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~27.38 miles east of Cairo
  • Low Cost hotel
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From$60
Not Good 1.0 /5 Review Score Call BookMore Details
 Econo Lodge Paducah West I-24 - Paducah 5120 Hinkleville Rd., Paducah, KY 42001
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~27.55 miles east of Cairo
  • Economical Airport hotel
  • Hotel has an eco-friendly policy Read more
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From$60
Average 3.0 /5 Hotel Reviews Call BookMore Details
Baymont by Wyndham Paducah in Paducah 5300 Old Cairo Rd., Paducah, KY 42001
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~27.64 miles east of Cairo
  • Mid-scale property
  • Check-in: 15:00
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From$40
Poor 2.0 /5 Reviews Call BookMore Details
Courtyard by Marriott Cape Girardeau Downtown - Cape Girardeau 400 Broadway St., Cape Girardeau, MO 63701
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~27.65 miles northwest of Cairo
  • Three Star Downtown hotel
  • Hotel has 78 rooms
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From$80
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Drury Suites Paducah in Paducah 2930 James Sanders Blvd., Paducah, KY 42001
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~27.70 miles east of Cairo
  • 3 star Suburban hotel
  • 138 rooms in hotel
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From$99
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Quality Suites Paducah I-24 : 2880 James Sanders Blvd. 2880 James Sanders Blvd., Paducah, KY 42001 Website
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~27.73 miles east of Cairo
  • Economy Highway property
  • Comp. Breakfast
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From$60
Average 3.0 /5 Reviews Call BookMore Details
Comfort Inn & Suites near Six Flags 960 West Pointe Court, Lithia Springs, GA 30122 Website
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~27.80 miles east of Cairo
  • Mid-scale Downtown hotel
  • 5 suites in property
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From$70
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Garner Hotel Paducah West by IHG - Paducah 145 Mcbride Lane, Paducah, KY 42001
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~27.80 miles east of Cairo
  • Mid-scale Highway hotel
  • 60 rooms in hotel
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From$49
Very Good 4.0 /5 Reviews Call BookMore Details
Hotel 7 Inn Paducah : 5001 Hinkleville Rd. 5001 Hinkleville Rd., Paducah, KY 42001
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~27.81 miles east of Cairo
  • Cheap hotel
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From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham Paducah in Paducah 3960 Coleman Crossing Cir, Paducah, KY 42001
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~27.90 miles east of Cairo
  • 3 star Highway property
  • 26 suites in hotel
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From$80
Average 3.0 /5 Guest Reviews Call BookMore Details
Candlewood Suites Paducah by IHG in Paducah 3940 Coleman Crossing Circle, Paducah, KY 42001
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~27.91 miles east of Cairo
  • Mid-scale Rural hotel
  • 85 rooms in property
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From$60
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Homewood Suites by Hilton Paducah 3925 Coleman Crossing Cir, Paducah, KY 42001
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~27.94 miles east of Cairo
  • Mid-scale Highway property
  • 97 suites in hotel
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From$109
Very Good 4.0 /5 Review Score Call BookMore Details
Comfort Suites in Paducah 3918 Coleman Crossing Cir Paducah Ky 42001, Paducah, KY 42001
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~27.96 miles east of Cairo
  • Economical Rural hotel
  • 72 rooms in hotel
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From$60
Average 3.0 /5 Recent Reviews Call BookMore Details
Comfort Inn Paducah 5135 Cairo Rd., Paducah, KY 42001
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~27.98 miles east of Cairo
  • 3 star hotel
  • 64 suites in hotel
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From$59
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Fairfield Inn & Suites by Marriott Paducah in Paducah 3950 Coleman Crossing Circle, Paducah, KY 42001
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~28.01 miles east of Cairo
  • Mid-scale Rural property
  • Gym / Fitness Center Available
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From$75
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Red Roof Inn Paducah : 5106 Old Cairo Rd. 5106 Old Cairo Rd., Paducah, KY 42001
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~28.01 miles east of Cairo
  • Cheap property
  • 3 floors in property
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From$45
Average 3.5 /5 Recent Reviews Call BookMore Details
American Inn 5125 Cairo Rd., Paducah, KY 42001
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~28.02 miles east of Cairo
  • Inexpensive hotel
  • Check in: 14:00
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From$37
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Hampton Inn & Suites Paducah - Paducah 3901 Coleman Crossing Circle, Paducah, KY 42001
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~28.02 miles east of Cairo
  • 3 star Highway hotel
  • 32 suites in hotel
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From$79
Very Good 4.5 /5 Guest Reviews Call BookMore Details
Holiday Inn Express Hotel & Suites Paducah West by IHG 3996 Hinkleville Rd., Paducah, KY 42001
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~28.04 miles east of Cairo
  • Affordable Highway hotel
  • Complimentary breakfast is offered
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From$80
Average 3.0 /5 Recent Reviews Call BookMore Details
Auburn Place Hotel & Suites - Paducah 3994 Hinkleville Rd., Paducah, KY 42001
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~28.05 miles east of Cairo
  • 3-star Airport property
  • 76 suites in hotel
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From$80
Very Good 4.0 /5 Reviews Call BookMore Details
Courtyard by Marriott Paducah 3835 Technology Dr., Paducah, KY 42001
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~28.29 miles east of Cairo
  • 3-star Suburban hotel
  • Check in time: 3:00 pm
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From$89
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Drury Inn Paducah 3975 Hinkleville Rd., Paducah, KY 42001
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~28.70 miles east of Cairo
  • Midscale Suburban hotel
  • Complimentary breakfast is offered
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From$79
Very Good 4.5 /5 Guest Reviews Call BookMore Details
Days Inn by Wyndham Paducah I-24 Exit 4 : 3901 Hinkleville Rd. 3901 Hinkleville Rd., Paducah, KY 42001
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~28.75 miles east of Cairo
  • Two star Highway property
  • 32 suites in hotel
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From$50
Average 3.0 /5 Recent Reviews Call BookMore Details
Candlewood Suites Cape Girardeau by IHG 485 South Mount Auburn Rd., Cape Girardeau, MO 65703
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~28.76 miles northwest of Cairo
  • Cheap Highway hotel
  • 85 suites in hotel
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From$69
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Travelers Inn and Suites : 2550 Lone Oak Rd. 2550 Lone Oak Rd., Paducah, KY 42003
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~28.88 miles east of Cairo
  • Economy property
  • Check-in time: 2:00PM
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From$38
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Quality Inn & Suites Metropolis I-24 : 2118 East 5th St. 2118 East 5th St., Metropolis, IL 62960
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~28.88 miles east of Cairo
  • Affordable hotel
  • Check in time: 11:00
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From$80
Very Good 4.0 /5 Reviews Call BookMore Details
Super 8 by Wyndham Metropolis : 2055 East 5th St. 2055 East 5th St., Metropolis, IL 62960
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~28.89 miles east of Cairo
  • Low Cost Highway hotel
  • 2 floors in property
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From$60
Average 3.0 /5 Read Reviews Call BookMore Details
Motel 6 Metropolis Il 2119 East 5th St., Metropolis, IL 62960
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~29.04 miles east of Cairo
  • Two-star property
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From$60
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Holiday Inn Express Metropolis by IHG - Metropolis 2179 East 5th St., Metropolis, IL 62960
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~29.10 miles east of Cairo
  • 3 star Rural property
  • 75 rooms in property
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From$65
Very Good 4.0 /5 Read Reviews Call BookMore Details
Hampton Inn Cape Girardeau I 55 East 207 South Mount Auburn Rd., Cape Girardeau, MO 63703
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~29.41 miles northwest of Cairo
  • Mid-scale Highway hotel
  • Check-in time: 3:00 pm
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From$80
Excellent 5.0 /5 Read Reviews Call BookMore Details
Victorian Inn & Suites 3256 William St., Cape Girardeau, MO 63703
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~29.41 miles northwest of Cairo
  • Three Star Golf Course property
  • 5 suites in property
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From$79
Average 3.0 /5 Latest Reviews Call BookMore Details
Auburn Place Hotel & Suites : 3265 Williams St. 3265 Williams St., Cape Girardeau, MO 63702
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~29.42 miles northwest of Cairo
  • 3 star Highway property
  • Free breakfast
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From$58
Very Good 4.5 /5 Recent Reviews Call BookMore Details

Next: See My Cairo Hotels with Pricing

Graph: Upcoming 20 Days of Cairo Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Cairo, IL discounts available. The chart reflects the cheapest Cairo hotel for each day and each star rating category.

FAQs about hotels in Cairo

What are the most favored hotels in Cairo?

Hampton Inn Cape Girardeau I 55 East, Drury Inn & Suites Sikeston and Hampton Inn & Suites Paducah are the best rated hotels based on customer reviews in the last 365 days.

What are the most luxurious hotels in Cairo?

Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destinatio, Quality Inn Cairo I-57 and Travel Inn & Suites - Sikeston are the top 3 luxury hotels near Cairo city center.

What hotels are closest to the city center of Cairo?

Quality Inn Cairo I-57, Super 8 by Wyndham Charleston, and The Riverstone Hotel Charleston-Sikeston are the properties closest to Cairo city center.

What are the best independent hotels in Cairo?

Auburn Place Hotel & Suites, Travel Inn & Suites - Sikeston and Drury Suites Paducah are the best rated independent hotels (not part of a big brand).

What are the most popular Marriott hotels in Cairo?

Residence Inn by Marriott Paducah, Courtyard by Marriott Cape Girardeau Downtown and Fairfield Inn & Suites by Marriott Paducah are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the best Choice Hotels branded hotels in Cairo?

Comfort Inn & Suites near Six Flags, Comfort Inn Paducah and Quality Inn & Suites Metropolis I-24 are the best rated Choice Hotels branded hotels (based on HotelPlanner reviews score).

What are the most popular IHG hotels in Cairo?

Candlewood Suites Paducah by IHG, Candlewood Suites Cape Girardeau by IHG and Holiday Inn Express Metropolis by IHG are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

Verified reviews of the city: Cairo, IL

Below are reviews of the city of Cairo, IL from an actual visitor's perspective.

"Spending time with my family"
Score 5.0 / 5

Vincent R., from 26-Jan-2026
The average traveler rating of the city of Cairo, IL shown above is 5.0 out of 5 based on 1 reviews
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