Desoto Missouri Accommodations

Find hotels in Desoto using the list and search tools below. Search for the cheapest discounted hotel and motel rates in or near Desoto, MO for your corporate or personal leisure travel. We show the best Desoto Missouri hotel rooms. Review the Desoto hotel list below to find the perfect lodging. We also have a map of the Desoto hotels.

Desoto Hotels/Accommodations

Holiday Inn Club Vac Timber Creek - Desoto 4800 Us Highway 67, Desoto, MO 63020 Call
  • 3 star hotel
  • 72 suites in hotel
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From$90
Very Good 4.5 /5 Guest Reviews Call BookMore Details
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IH in Festus 1802 Gamel Cemetery Rd., Festus, MO 63028 Call ~9.28 miles northeast of Desoto
  • Inexpensive Highway property
  • Hotel has 85 rooms
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From$90
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Comfort Inn Festus - St Louis South - Festus 1303 Veterans Blvd., Festus, MO 63028 Website Call ~9.48 miles northeast of Desoto
  • 3 star Suburban hotel
  • Check-in time: 3:00 PM
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From$45
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Baymont by Wyndham Festus 1200 West Gannon Dr., Festus, MO 63028 Call ~9.51 miles northeast of Desoto
  • Mid-scale Suburban property
  • 134 rooms in property
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From$72
Average 3.0 /5 Review Score Call BookMore Details
La Quinta Inn & Suites by Wyndham Festus - St. Louis South in Festus 1001 Veterans Blvd., Festus, MO 63028 Call ~9.70 miles northeast of Desoto
  • Affordable Suburban hotel
  • Check in: 3:00 PM
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From$80
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Super 8 by Wyndham Pevely 1711 Highway Z, Pevely, MO 63070 Call ~13.03 miles northeast of Desoto
  • Two star hotel
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From$35
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Super 8 by Wyndham Bonne Terre in Bonne Terre 8 Northwood Dr., Bonne Terre, MO 63628 Call ~14.93 miles south of Desoto
  • 2-star hotel
  • Check in time: 11:00 AM
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From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
Motel 6 Bonne Terre Mo 1017 Highway K, Bonne Terre, MO 63628 Call ~15.12 miles south of Desoto
  • Cheap property
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From$60
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Super 8 by Wyndham Potosi : 820 East High St. 820 East High St., Potosi, MO 63664 Call ~18.89 miles southwest of Desoto
  • 2 star Highway hotel
  • Check-in time: 2 pm
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From$49
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Quality Inn & Suites - Arnold 3610 West Outer Rd., Arnold, MO 63010 Website Call ~20.97 miles northeast of Desoto
  • Cheap Suburban hotel
  • Hotel has an eco-friendly policy See more
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From$60
Average 3.0 /5 Reviews Call BookMore Details
Woodspring Suites St. Louis Arnold 888 Arnold Commons Dr., Arnold, MO 63010 Call ~22.46 miles northeast of Desoto
  • Economical Highway hotel
  • 4 floors in property
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From$32
Very Good 4.0 /5 Reviews Call BookMore Details
Crown Pointe Lodge, BW Signature Collection in Farmington 4245 Hunt Rd., Farmington, MO 63640 Call ~23.27 miles south of Desoto
  • 3-star Golf Course hotel
  • Free breakfast available
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From$64
Very Good 4.0 /5 Reviews Call BookMore Details
Best Western St. Louis Inn : 6224 Heimos Industrial Park Dr. 6224 Heimos Industrial Park Dr., Saint Louis, MO 63129 Call ~24.42 miles northeast of Desoto
  • Low-priced Suburban hotel
  • Free breakfast available
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From$41
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Hampton Inn Farmington 850 Valley Creek Dr., Farmington, MO 63640 Call ~24.70 miles south of Desoto
  • Midscale Highway hotel
  • Check-in: 3:00pm
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From$80
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Super 8 by Wyndham Farmington 930 Valley Creek Dr., Farmington, MO 63640 Call ~24.77 miles south of Desoto
  • Two-star hotel
  • 60 rooms in property
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From$49
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Holiday Inn Express & Suites Farmington by IHG : 820 Market St. 820 Market St., Farmington, MO 63640 Call ~24.80 miles south of Desoto
  • 3 star Rural property
  • 60 sleeping rooms in hotel
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From$99
Very Good 4.0 /5 Latest Reviews Call BookMore Details
680 Fenton Business Park Ct Fenton Missouri 63026 - Fenton Fenton Business Park Court Fenton, Fenton, IA 63026 Call ~25.48 miles north of Desoto
  • 3 star hotel
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From$80
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Quality Inn Farmington 1400 West Liberty St., Farmington, MO 63640 Call ~25.62 miles south of Desoto
  • 3-star Rural property
  • 48 rooms in property
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From$80
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America's Best Inn Eureka in Eureka 1725 West 5th St., Eureka, MO 63025 Call ~25.87 miles north of Desoto
  • Inexpensive Highway property
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From$60
Poor 2.0 /5 Review Score Call BookMore Details
Super 8 by Wyndham Eureka/Six Flags Nearby : 1733 West 5th St. 1733 West 5th St., Eureka, MO 63025 Call ~25.94 miles north of Desoto
  • Low priced Highway property
  • Check-in time: ex. 3:00 PM
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From$60
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Baymont Inn and Suites by Wyndham Farmington, MO - Farmington 1625 West Columbia St., Farmington, MO 63640 Call ~25.97 miles south of Desoto
  • Mid-scale Highway hotel
  • Hotel has 2 floors
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From$80
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Fairfield Inn N Ste St. Louis South 4318 Butler Hill Rd., St Louis, MO 63128 Call ~26.09 miles northeast of Desoto
  • Three Star property
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From$90
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Holiday Inn Express & Suites St. Louis South - I-55 by IHG : 4250 Midamerica Ln 4250 Midamerica Ln, St. Louis, MO 63129 Call ~26.13 miles northeast of Desoto
  • Mid-scale Suburban property
  • Hotel has 2 meeting rooms
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From$80
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Quality Inn Near Six Flags St. Louis : 1400 West Osage St. 1400 West Osage St., Pacific, MO 63069 Call ~26.17 miles northwest of Desoto
  • 3 star Rural hotel
  • Comp. Breakfast
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From$80
Very Good 4.0 /5 Reviews Call BookMore Details
Hampton Inn & Suites St. Louis/South I-55 - St. Louis 4200 Midamerica Ln, St. Louis, MO 63129 Call ~26.18 miles northeast of Desoto
  • 3 star Suburban property
  • 4 floors in property
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From$80
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Comfort Inn Near Six Flags St. Louis 1320 Thornton St., Pacific, MO 63069 Website Call ~26.28 miles northwest of Desoto
  • Three Star Highway property
  • Hotel has 3 floors
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From$88
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Holiday Inn St. Louis West Six Flags by IHG - Eureka 4901 Six Flags Rd., Eureka, MO 63025 Call ~26.41 miles north of Desoto
  • 3-star Suburban hotel
  • 11 suites in property
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From$129
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Super 8 by Wyndham Waterloo 112 Warren Dr., Waterloo, IL 62298 Call ~26.68 miles northeast of Desoto
  • Low Cost Rural hotel
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From$60
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Super 8 by Wyndham St. Clair MO in Saint Clair 1010 South Outer Rd., Saint Clair, MO 63077 Call ~27.53 miles northwest of Desoto
  • Low priced Highway property
  • Free breakfast available
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From$60
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Pinemark Inn & Suites 866 South Outer Rd., St. Clair, MO 63077 Call ~27.60 miles northwest of Desoto
  • Cheap Highway property
  • Free breakfast
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From$61
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Hampton Inn St. Louis Southwest 9 Lambert Drury Place, St. Louis, MO 63088 Call ~27.66 miles north of Desoto
  • 3-star Suburban hotel
  • Comp. Breakfast
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From$85
Very Good 4.5 /5 Recent Reviews Call BookMore Details
Hampton Inn St. Louis Columbia 165 Admiral Trost Dr., Columbia, IL 62236 Call ~27.76 miles northeast of Desoto
  • Affordable Suburban hotel
  • Check in time: 3:00 PM
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From$80
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Holiday Inn Express St. Louis West Fenton 1848 Bowles Ave., Fenton, MO 63026 Call ~27.97 miles north of Desoto
  • 3 star Suburban property
  • Check-in time: 03:00 PM
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From$80
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Motel 6 Fenton Mo 1860 Bowles Ave., Fenton, MO 63026 Call ~27.99 miles north of Desoto
  • 2 star hotel
  • 58 rooms in property
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From$60
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Wingate by Wyndham St. Louis / Fenton Route 66 1100 South Highway Dr., Fenton, MO 63026 Call ~28.11 miles north of Desoto
  • Affordable Suburban property
  • 3 floors in property
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From$80
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Heritage Inn & Suites St. Louis / Fenton Trademark by Wyndham : 1088 South Highway Dr. 1088 South Highway Dr., Fenton, MO 63026 Call ~28.17 miles north of Desoto
  • Affordable Suburban hotel
  • Hotel has 11 suites
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From$80
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Extended Stay America Suites St. Louis Fenton in Fenton 1662 Fenton Business Park Court, Fenton, MO 63026 Call ~28.25 miles north of Desoto
  • Affordable Suburban hotel
  • Check in: 3:00 pm
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From$80
Average 3.0 /5 Recent Reviews Call BookMore Details
Americas Best Value Inn St. Louis South in St. Louis 6602 South Lindbergh Blvd., St. Louis, MO 63123 Call ~28.28 miles northeast of Desoto
  • Economical Suburban hotel
  • Free breakfast
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From$49
Poor 2.0 /5 Latest Reviews Call BookMore Details
Best Western Plus Fenton : 1680 Fenton Business Park Court 1680 Fenton Business Park Court, Fenton, MO 63026 Call ~28.32 miles north of Desoto
  • 3-star Suburban property
  • 102 sleeping rooms in hotel
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From$64
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Super 8 by Wyndham Fenton/St. Louis Area : 650 South Highway Dr. 650 South Highway Dr., Fenton, MO 63026 Call ~28.34 miles north of Desoto
  • Cheap property
  • Check in time: 15:00
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From$60
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Aviator Hotel & Suites 6921 South Lindbergh Blvd., St Louis, MO 63125 Call ~28.36 miles northeast of Desoto
  • Three Star Suburban hotel
  • Hotel has 149 rooms
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From$80
Average 3.0 /5 Recent Reviews Call BookMore Details
Comfort Suites St. Louis - St. Louis 3654 South Lindbergh Blvd., St. Louis, MO 63127 Call ~29.13 miles north of Desoto
  • 2-star Suburban property
  • Hotel has an eco-friendly policy See more
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From$49
Average 3.5 /5 Reviews Call BookMore Details
Microtel Inn & Suites by Wyndham Sainte Genevieve in Ste. Genevieve 21958 State Highway 32, Ste. Genevieve, MO 63670 Call ~29.55 miles east of Desoto
  • Low-priced Highway property
  • 48 rooms in hotel
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From$50
Average 3.0 /5 Guest Reviews Call BookMore Details
Days Inn by Wyndham St. Louis Lindbergh Boulevard : 3660 South Lindbergh Blvd. 3660 South Lindbergh Blvd., St Louis, MO 63127 Call ~29.61 miles north of Desoto
  • Affordable Suburban hotel
  • 116 rooms in property
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From$69
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Holiday Inn St. Louis Sw Route 66 An Ihg Hotel 10709 Watson Rd., St. Louis, MO 63127 Call ~29.78 miles north of Desoto
  • Three Star Suburban property
  • Fitness center on property
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From$79
Average 3.0 /5 Latest Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham : 1580 South Kirkwood Rd. 1580 South Kirkwood Rd., Saint Louis, MO 63127 Call ~29.85 miles north of Desoto
  • Midscale Suburban hotel
  • Free breakfast available
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From$100
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Best Western St. Louis-Kirkwood Route 66 - Saint Louis 1200 South Kirkwood Rd., Saint Louis, MO 63122 Call ~30.29 miles north of Desoto
  • Midscale Suburban property
  • Access to gym on-site
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From$70
Very Good 4.0 /5 Reviews Call BookMore Details
The Wildwood Hotel - Wildwood 2801 Fountain Place, Wildwood, MO 63040 Call ~30.75 miles north of Desoto
  • High-end Suburban property
  • Fitness + Health Center
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From$100
Very Good 4.0 /5 Review Score Call BookMore Details
Super 8 by Wyndham Union : 1015 East Main St. 1015 East Main St., Union, MO 63084 Call ~31.92 miles northwest of Desoto
  • Inexpensive Rural property
  • Free breakfast
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From$67
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Residence Inn by Marriott St. Louis West County - St. Louis 12815b Daylight Dr., St. Louis, MO 63131 Website Call ~32.70 miles north of Desoto
  • Three Star Suburban property
  • Check-in time: 3pm
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From$99
Very Good 4.0 /5 Latest Reviews Call BookMore Details

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