Desoto Missouri Accommodations

Find hotels in Desoto using the list and search tools below. Search for the cheapest discounted hotel and motel rates in or near Desoto, MO for your corporate or personal leisure travel. We show the best Desoto Missouri hotel rooms. Review the Desoto hotel list below to find the perfect lodging. We also have a map of the Desoto hotels.

Desoto Hotels, Motels & Accommodations

Holiday Inn Club Vac Timber Creek 4800 Us Highway 67, Desoto, MO 63020 Call
  • Midscale hotel
  • Hotel has an eco-friendly policy See policy
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From£80 total
Very good 4.5 /5 Guest Reviews Call BookMore Details
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IH in Festus 1802 Gamel Cemetery Rd., Festus, MO 63028 Call ~9.28 miles northeast of Desoto
  • 2 star Highway property
  • Complimentary breakfast is offered
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From£80 total
Very good 4.0 /5 Review Score Call BookMore Details
Comfort Inn Festus in Festus 1303 Veterans Blvd., Festus, MO 63028 Website Call ~9.48 miles northeast of Desoto
  • Affordable Suburban hotel
  • 89 rooms in property
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From£71 total
Average 3.0 /5 Recent Reviews Call BookMore Details
Baymont by Wyndham Festus - Festus 1200 West Gannon Dr., Festus, MO 63028 Call ~9.51 miles northeast of Desoto
  • Three Star Suburban property
  • Complimentary breakfast is offered
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From£64 total
Average 3.0 /5 Latest Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham Festus - St. Louis South in Festus 1001 Veterans Blvd., Festus, MO 63028 Call ~9.70 miles northeast of Desoto
  • 3 star Suburban property
  • Complimentary breakfast is offered
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From£71 total
Average 3.0 /5 Latest Reviews Call BookMore Details
Super 8 by Wyndham Pevely in Pevely 1711 Highway Z, Pevely, MO 63070 Call ~13.03 miles northeast of Desoto
  • Two star property
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From£31 total
Very good 4.0 /5 Reviews Call BookMore Details
Super 8 by Wyndham Bonne Terre : 8 Northwood Dr. 8 Northwood Dr., Bonne Terre, MO 63628 Call ~14.93 miles south of Desoto
  • Low priced hotel
  • Check-in time: 11:00 AM
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From£53 total
Average 3.0 /5 Reviews Call BookMore Details
Motel 6 Bonne Terre Mo 1017 Highway K, Bonne Terre, MO 63628 Call ~15.12 miles south of Desoto
  • Inexpensive hotel
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From£53 total
Average 3.0 /5 Guest Reviews Call BookMore Details
Super 8 by Wyndham Potosi : 820 East High St. 820 East High St., Potosi, MO 63664 Call ~18.89 miles southwest of Desoto
  • Two-star Highway property
  • Hotel has 2 floors
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From£43 total
Average 3.0 /5 Reviews Call BookMore Details
Quality Inn & Suites 3610 West Outer Rd., Arnold, MO 63010 Call ~20.97 miles northeast of Desoto
  • 2 star Suburban hotel
  • Fitness center on property
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From£53 total
Average 3.0 /5 Recent Reviews Call BookMore Details
Woodspring Suites St. Louis Arnold - Arnold 888 Arnold Commons Dr., Arnold, MO 63010 Call ~22.46 miles northeast of Desoto
  • Two star Highway property
  • 124 rooms in property
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From£28 total
Very good 4.0 /5 Recent Reviews Call BookMore Details
Drury Inn & Suites St. Louis Arnold in Arnold 3800 State Rt 141, Arnold, MO 63010 Call ~22.57 miles northeast of Desoto
  • 3-star Suburban hotel
  • 6 floors in property
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From£109 total
Excellent 5.0 /5 Guest Reviews Call BookMore Details
Pear Tree Inn St. Louis Arnold 1201 Drury Lane, Arnold, MO 63010 Call ~23.16 miles northeast of Desoto
  • Mid-scale Suburban hotel
  • Hotel has a green policy Learn more
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From£71 total
Very good 4.0 /5 Guest Reviews Call BookMore Details
Crown Pointe Lodge, BW Signature Collection 4245 Hunt Rd., Farmington, MO 63640 Call ~23.27 miles south of Desoto
  • 3 star Golf Course hotel
  • Hotel has 3 floors
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From£57 total
Very good 4.0 /5 Recent Reviews Call BookMore Details
Best Western St. Louis Inn : 6224 Heimos Industrial Park Dr. 6224 Heimos Industrial Park Dr., Saint Louis, MO 63129 Call ~24.42 miles northeast of Desoto
  • 2-star Suburban hotel
  • Check-in time: 03:00
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From£36 total
Average 3.0 /5 Latest Reviews Call BookMore Details
Hampton Inn Farmington in Farmington 850 Valley Creek Dr., Farmington, MO 63640 Call ~24.70 miles south of Desoto
  • Midscale Highway hotel
  • 6 meeting rooms in property
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From£71 total
Average 3.0 /5 Read Reviews Call BookMore Details
Super 8 by Wyndham Farmington - Farmington 930 Valley Creek Dr., Farmington, MO 63640 Call ~24.77 miles south of Desoto
  • Low-priced property
  • Hotel has 60 rooms
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From£43 total
Average 3.0 /5 Read Reviews Call BookMore Details
Holiday Inn Express & Suites Farmington by IHG in Farmington 820 Market St., Farmington, MO 63640 Call ~24.80 miles south of Desoto
  • 3-star Rural hotel
  • 60 sleeping rooms in hotel
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From£88 total
Very good 4.0 /5 Recent Reviews Call BookMore Details
680 Fenton Business Park Ct Fenton Missouri 63026 - Fenton Fenton Business Park Court Fenton, Fenton, IA 63026 Call ~25.48 miles north of Desoto
  • 3 star property
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From£71 total
Average 3.0 /5 Reviews Call BookMore Details
Quality Inn Farmington in Farmington 1400 West Liberty St., Farmington, MO 63640 Call ~25.62 miles south of Desoto
  • Midscale Rural property
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From£71 total
Average 3.0 /5 Reviews Call BookMore Details
America's Best Inn Eureka : 1725 West 5th St. 1725 West 5th St., Eureka, MO 63025 Call ~25.87 miles north of Desoto
  • Low-priced Highway property
  • Check-in time: 11.00am
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From£53 total
Poor 2.0 /5 Read Reviews Call BookMore Details
Super 8 by Wyndham Eureka/Six Flags Nearby 1733 West 5th St., Eureka, MO 63025 Call ~25.94 miles north of Desoto
  • Economical Highway property
  • Check in: ex. 3:00 PM
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From£53 total
Average 3.0 /5 Latest Reviews Call BookMore Details
Baymont Inn and Suites by Wyndham Farmington, MO in Farmington 1625 West Columbia St., Farmington, MO 63640 Call ~25.97 miles south of Desoto
  • Three Star Highway property
  • Check in time: 04:00
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From£71 total
Average 3.0 /5 Read Reviews Call BookMore Details
Fairfield Inn N Ste St. Louis South : 4318 Butler Hill Rd. 4318 Butler Hill Rd., St Louis, MO 63128 Call ~26.09 miles northeast of Desoto
  • Midscale hotel
  • Check in: 15:00
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From£80 total
Average 3.0 /5 Reviews Call BookMore Details
Holiday Inn Express & Suites St. Louis South I 55 by IHG in St. Louis 4250 Midamerica Ln, St. Louis, MO 63129 Call ~26.13 miles northeast of Desoto
  • 3-star Suburban hotel
  • 99 rooms in property
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From£71 total
Average 3.0 /5 Hotel Reviews Call BookMore Details
Quality Inn Near Six Flags St. Louis 1400 West Osage St., Pacific, MO 63069 Call ~26.17 miles northwest of Desoto
  • 3-star Rural property
  • Complimentary breakfast is offered
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From£71 total
Very good 4.0 /5 Read Reviews Call BookMore Details
Hampton Inn & Suites St. Louis/South I-55 in St. Louis 4200 Midamerica Ln, St. Louis, MO 63129 Call ~26.18 miles northeast of Desoto
  • 3 star Suburban property
  • 92 sleeping rooms in hotel
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From£71 total
Very good 4.0 /5 Reviews Call BookMore Details
Comfort Inn Near Six Flags St. Louis 1320 Thornton St., Pacific, MO 63069 Call ~26.28 miles northwest of Desoto
  • Midscale Highway hotel
  • Check in: 3:00PM
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From£78 total
Average 3.0 /5 Review Score Call BookMore Details
Holiday Inn St. Louis West Six Flags by IHG in Eureka 4901 Six Flags Rd., Eureka, MO 63025 Call ~26.41 miles north of Desoto
  • 3 star Suburban hotel
  • 4 meeting rooms in hotel
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From£115 total
Average 3.0 /5 Latest Reviews Call BookMore Details
Super 8 by Wyndham Waterloo 112 Warren Dr., Waterloo, IL 62298 Call ~26.68 miles northeast of Desoto
  • 2 star Rural property
  • Free comp. breakfast
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From£53 total
Average 3.5 /5 Guest Reviews Call BookMore Details
Super 8 by Wyndham St. Clair MO - Saint Clair 1010 South Outer Rd., Saint Clair, MO 63077 Call ~27.53 miles northwest of Desoto
  • Economical Highway hotel
  • 51 rooms in hotel
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From£53 total
Average 3.0 /5 Read Reviews Call BookMore Details
Pinemark Inn & Suites 866 South Outer Rd., St. Clair, MO 63077 Call ~27.60 miles northwest of Desoto
  • Economy Highway property
  • Free complimentary breakfast
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From£54 total
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Hampton Inn St. Louis Southwest : 9 Lambert Drury Place 9 Lambert Drury Place, St. Louis, MO 63088 Call ~27.66 miles north of Desoto
  • 3 star Suburban hotel
  • 92 rooms in hotel
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From£75 total
Very good 4.5 /5 Guest Reviews Call BookMore Details
Drury Inn & Suites St. Louis Southwest in St. Louis 5 Lambert Drury Place (I 44 & 141), St. Louis, MO 63088 Call ~27.66 miles north of Desoto
  • Midscale Suburban property
  • 2 meeting rooms in property
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From£75 total
Very good 4.5 /5 Review Score Call BookMore Details
Hampton Inn St. Louis Columbia 165 Admiral Trost Dr., Columbia, IL 62236 Call ~27.76 miles northeast of Desoto
  • Mid-scale Suburban hotel
  • Check in time: 3:00 PM
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From£71 total
Average 3.0 /5 Hotel Reviews Call BookMore Details
Holiday Inn Express & Suites St. Louis West - Fenton by IHG in Fenton 1848 Bowles Ave., Fenton, MO 63026 Call ~27.97 miles north of Desoto
  • Three Star Suburban hotel
  • Comp. Breakfast
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From£71 total
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Motel 6 Fenton Mo in Fenton 1860 Bowles Ave., Fenton, MO 63026 Call ~27.99 miles north of Desoto
  • 2-star property
  • 58 rooms in hotel
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From£53 total
Average 3.0 /5 Recent Reviews Call BookMore Details
Wingate by Wyndham St. Louis / Fenton Route 66 1100 South Highway Dr., Fenton, MO 63026 Call ~28.11 miles north of Desoto
  • 3-star Suburban hotel
  • Gym is available on property
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From£71 total
Average 3.0 /5 Latest Reviews Call BookMore Details
Heritage Inn & Suites St. Louis / Fenton Trademark by Wyndham 1088 South Highway Dr., Fenton, MO 63026 Call ~28.17 miles north of Desoto
  • Midscale Suburban property
  • Free comp. breakfast
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From£71 total
Average 3.0 /5 Read Reviews Call BookMore Details
Extended Stay America Suites St. Louis Fenton : 1662 Fenton Business Park Court 1662 Fenton Business Park Court, Fenton, MO 63026 Call ~28.25 miles north of Desoto
  • Three Star Suburban property
  • 94 rooms in hotel
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From£71 total
Average 3.0 /5 Hotel Reviews Call BookMore Details
Americas Best Value Inn St. Louis South : 6602 South Lindbergh Blvd. 6602 South Lindbergh Blvd., St. Louis, MO 63123 Call ~28.28 miles northeast of Desoto
  • Low-priced Suburban property
  • Free breakfast
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From£43 total
Poor 2.0 /5 Guest Reviews Call BookMore Details
Best Western Plus Fenton 1680 Fenton Business Park Court, Fenton, MO 63026 Call ~28.32 miles north of Desoto
  • Three Star Suburban hotel
  • Gym / Fitness Center Available
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From£57 total
Average 3.0 /5 Hotel Reviews Call BookMore Details
Super 8 by Wyndham Fenton/St. Louis Area 650 South Highway Dr., Fenton, MO 63026 Call ~28.34 miles north of Desoto
  • Low-priced hotel
  • Check in time: 15:00
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From£53 total
Poor 2.0 /5 Hotel Reviews Call BookMore Details
Aviator Hotel & Suites in St Louis 6921 South Lindbergh Blvd., St Louis, MO 63125 Call ~28.36 miles northeast of Desoto
  • 3-star Suburban property
  • Check-in: 04:00
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From£71 total
Average 3.0 /5 Recent Reviews Call BookMore Details
Comfort Suites St. Louis : 3654 South Lindbergh Blvd. 3654 South Lindbergh Blvd., St. Louis, MO 63127 Call ~29.13 miles north of Desoto
  • Economy Suburban property
  • 160 rooms in hotel
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From£43 total
Average 3.5 /5 Recent Reviews Call BookMore Details
Microtel Inn & Suites by Wyndham Sainte Genevieve 21958 State Highway 32, Ste. Genevieve, MO 63670 Call ~29.55 miles east of Desoto
  • Economy Highway property
  • 6 suites in hotel
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From£44 total
Average 3.0 /5 Guest Reviews Call BookMore Details
Days Inn by Wyndham St. Louis Lindbergh Boulevard in St Louis 3660 South Lindbergh Blvd., St Louis, MO 63127 Call ~29.61 miles north of Desoto
  • Mid-scale Suburban hotel
  • Free breakfast available
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From£61 total
Average 3.0 /5 Guest Reviews Call BookMore Details
Holiday Inn St. Louis Sw Route 66 An Ihg Hotel - St. Louis 10709 Watson Rd., St. Louis, MO 63127 Call ~29.78 miles north of Desoto
  • 3 star Suburban property
  • 4 floors in hotel
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From£70 total
Average 3.0 /5 Hotel Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham 1580 South Kirkwood Rd., Saint Louis, MO 63127 Call ~29.85 miles north of Desoto
  • Three Star Suburban property
  • Check in: 3:00PM
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From£89 total
Average 3.0 /5 Review Score Call BookMore Details
Best Western St. Louis-Kirkwood Route 66 - Saint Louis 1200 South Kirkwood Rd., Saint Louis, MO 63122 Call ~30.29 miles north of Desoto
  • 3 star Suburban property
  • Hotel has 6 floors
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From£62 total
Very good 4.0 /5 Latest Reviews Call BookMore Details

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