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Desoto Missouri Accommodations

Find hotels in Desoto using the list and search tools below. Search for the cheapest discounted hotel and motel rates in or near Desoto, MO for your corporate or personal leisure travel. We show the best Desoto Missouri hotel rooms. Review the Desoto hotel list below to find the perfect lodging. We also have a map of the Desoto hotels.

Desoto Hotels & Accommodations

Holiday Inn Club Vac Timber Creek 4800 Us Highway 67, Desoto, MO 63020
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  • 3 star hotel
  • Check in: 16:00
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From$90
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Holiday Inn Express Hotel & Suites Festus South St. Louis by Ih in Festus 1802 Gamel Cemetery Rd., Festus, MO 63028
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~9.28 miles northeast of Desoto
  • Low priced Highway property
  • Hotel has 23 suites
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From$90
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Comfort Inn Festus St. Louis South 1303 Veterans Blvd., Festus, MO 63028 Website
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~9.48 miles northeast of Desoto
  • Three Star Suburban hotel
  • Check-in: 3:00 PM
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From$45
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Baymont by Wyndham Festus - Festus 1200 West Gannon Dr., Festus, MO 63028
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~9.51 miles northeast of Desoto
  • 3-star Suburban property
  • Check-in: 11:00
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From$72
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La Quinta Inn & Suites by Wyndham Festus - St. Louis South in Festus 1001 Veterans Blvd., Festus, MO 63028
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~9.70 miles northeast of Desoto
  • Midscale Suburban property
  • Check-in time: 3:00 PM
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From$80
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Super 8 by Wyndham Pevely 1711 Highway Z, Pevely, MO 63070
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~13.03 miles northeast of Desoto
  • Inexpensive hotel
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From$35
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Super 8 by Wyndham Bonne Terre - Bonne Terre 8 Northwood Dr., Bonne Terre, MO 63628
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~14.93 miles south of Desoto
  • Low-priced property
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From$60
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Motel 6 Bonne Terre Mo in Bonne Terre 1017 Highway K, Bonne Terre, MO 63628
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~15.12 miles south of Desoto
  • Low-priced hotel
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From$60
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Super 8 by Wyndham Potosi - Potosi 820 East High St., Potosi, MO 63664
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~18.89 miles southwest of Desoto
  • Low priced Highway property
  • 48 rooms in property
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From$49
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Quality Inn & Suites : 3610 West Outer Rd. 3610 West Outer Rd., Arnold, MO 63010 Website
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~20.97 miles northeast of Desoto
  • Economy Suburban property
  • Hotel has a green policy See policy
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From$60
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Woodspring Suites St. Louis Arnold 888 Arnold Commons Dr., Arnold, MO 63010
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~22.46 miles northeast of Desoto
  • Low-priced Highway hotel
  • Hotel has 124 rooms
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From$32
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Crown Pointe Lodge, BW Signature Collection - Farmington 4245 Hunt Rd., Farmington, MO 63640
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~23.27 miles south of Desoto
  • 3 star Golf Course hotel
  • Hotel has 17 suites
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From$61
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Best Western St. Louis Inn 6224 Heimos Industrial Park Dr., Saint Louis, MO 63129
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~24.42 miles northeast of Desoto
  • Cheap Suburban property
  • Check in: 03:00
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From$40
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Hampton Inn Farmington 850 Valley Creek Dr., Farmington, MO 63640
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~24.70 miles south of Desoto
  • Midscale Highway property
  • Fitness + Health Center
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From$80
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Super 8 by Wyndham Farmington - Farmington 930 Valley Creek Dr., Farmington, MO 63640
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~24.77 miles south of Desoto
  • Two star hotel
  • 60 rooms in property
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From$49
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Holiday Inn Express & Suites Farmington by IHG - Farmington 820 Market St., Farmington, MO 63640
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~24.80 miles south of Desoto
  • Three Star Rural hotel
  • 3 floors in property
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From$99
Very Good 4.0 /5 Reviews Call BookMore Details
680 Fenton Business Park Ct Fenton Missouri 63026 - Fenton Fenton Business Park Court Fenton, Fenton, IA 63026
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~25.48 miles north of Desoto
  • 3-star hotel
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From$80
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Quality Inn Farmington - Farmington 1400 West Liberty St., Farmington, MO 63640
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~25.62 miles south of Desoto
  • Affordable Rural hotel
  • Hotel has 48 rooms
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From$80
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America's Best Inn Eureka - Eureka 1725 West 5th St., Eureka, MO 63025
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~25.87 miles north of Desoto
  • Cheap Highway hotel
  • Check in: 11.00am
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From$60
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Super 8 by Wyndham Eureka/Six Flags Nearby 1733 West 5th St., Eureka, MO 63025
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~25.94 miles north of Desoto
  • 2 star Highway property
  • Free comp. breakfast
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From$60
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Baymont Inn and Suites by Wyndham Farmington, MO - Farmington 1625 West Columbia St., Farmington, MO 63640
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~25.97 miles south of Desoto
  • Midscale Highway hotel
  • Check in: 04:00
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From$80
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Fairfield Inn N Ste St. Louis South - St Louis 4318 Butler Hill Rd., St Louis, MO 63128
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~26.09 miles northeast of Desoto
  • 3-star property
  • Check-in time: 15:00
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From$90
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Holiday Inn Express & Suites St. Louis South - I-55 by IHG - St. Louis 4250 Midamerica Ln, St. Louis, MO 63129
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~26.13 miles northeast of Desoto
  • Mid-scale Suburban hotel
  • Hotel has a green policy See more
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From$80
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Quality Inn Near Six Flags St. Louis 1400 West Osage St., Pacific, MO 63069
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~26.17 miles northwest of Desoto
  • 3 star Rural property
  • Hotel has 46 rooms
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From$80
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Hampton Inn & Suites St. Louis/South I-55 - St. Louis 4200 Midamerica Ln, St. Louis, MO 63129
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~26.18 miles northeast of Desoto
  • Three Star Suburban hotel
  • Check-in time: 3:00pm
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From$80
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Comfort Inn Near Six Flags St. Louis 1320 Thornton St., Pacific, MO 63069 Website
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~26.28 miles northwest of Desoto
  • Affordable Highway hotel
  • Access to gym on-site
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From$88
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Holiday Inn St. Louis West Six Flags by IHG in Eureka 4901 Six Flags Rd., Eureka, MO 63025
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~26.41 miles north of Desoto
  • Mid-scale Suburban property
  • 3 floors in hotel
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From$129
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Super 8 by Wyndham Waterloo : 112 Warren Dr. 112 Warren Dr., Waterloo, IL 62298
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~26.68 miles northeast of Desoto
  • Two-star Rural hotel
  • Check in: 3:00 PM
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From$60
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Super 8 by Wyndham St. Clair MO - Saint Clair 1010 South Outer Rd., Saint Clair, MO 63077
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~27.53 miles northwest of Desoto
  • Low Cost Highway hotel
  • 3 floors in property
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From$60
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Pinemark Inn & Suites 866 South Outer Rd., St. Clair, MO 63077
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~27.60 miles northwest of Desoto
  • Inexpensive Highway hotel
  • Complimentary breakfast is offered
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From$61
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Hampton Inn St. Louis Southwest 9 Lambert Drury Place, St. Louis, MO 63088
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~27.66 miles north of Desoto
  • Three Star Suburban hotel
  • Check in: 03:00 PM
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From$85
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Hampton Inn St. Louis Columbia 165 Admiral Trost Dr., Columbia, IL 62236
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~27.76 miles northeast of Desoto
  • Affordable Suburban property
  • 3 floors in property
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From$80
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Holiday Inn Express St. Louis West Fenton 1848 Bowles Ave., Fenton, MO 63026
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~27.97 miles north of Desoto
  • Affordable Suburban property
  • Comp. Breakfast
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From$80
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Motel 6 Fenton Mo - Fenton 1860 Bowles Ave., Fenton, MO 63026
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~27.99 miles north of Desoto
  • 2 star property
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From$60
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Wingate by Wyndham St. Louis / Fenton Route 66 in Fenton 1100 South Highway Dr., Fenton, MO 63026
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~28.11 miles north of Desoto
  • 3 star Suburban property
  • Has environment-friendly policy See more
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From$80
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Heritage Inn & Suites St. Louis / Fenton Trademark by Wyndham : 1088 South Highway Dr. 1088 South Highway Dr., Fenton, MO 63026
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~28.17 miles north of Desoto
  • Midscale Suburban hotel
  • 4 floors in hotel
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From$80
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Extended Stay America Suites St. Louis Fenton 1662 Fenton Business Park Court, Fenton, MO 63026
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~28.25 miles north of Desoto
  • Mid-scale Suburban property
  • 94 sleeping rooms in hotel
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From$80
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Americas Best Value Inn St. Louis South 6602 South Lindbergh Blvd., St. Louis, MO 63123
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~28.28 miles northeast of Desoto
  • Low Cost Suburban hotel
  • 3 floors in property
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From$49
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Best Western Plus Fenton 1680 Fenton Business Park Court, Fenton, MO 63026
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~28.32 miles north of Desoto
  • 3 star Suburban hotel
  • Free breakfast
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From$61
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Super 8 by Wyndham Fenton/St. Louis Area 650 South Highway Dr., Fenton, MO 63026
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~28.34 miles north of Desoto
  • 2 star property
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From$60
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Aviator Hotel & Suites 6921 South Lindbergh Blvd., St Louis, MO 63125
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~28.36 miles northeast of Desoto
  • Three Star Suburban hotel
  • 8 meeting rooms in property
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From$80
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Comfort Suites St. Louis 3654 South Lindbergh Blvd., St. Louis, MO 63127
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~29.13 miles north of Desoto
  • Economical Suburban hotel
  • Check in: 2:00 pm
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From$49
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Microtel Inn & Suites by Wyndham Sainte Genevieve - Ste. Genevieve 21958 State Highway 32, Ste. Genevieve, MO 63670
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~29.55 miles east of Desoto
  • Low-priced Highway property
  • 6 suites in property
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From$50
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Days Inn by Wyndham St. Louis Lindbergh Boulevard in St Louis 3660 South Lindbergh Blvd., St Louis, MO 63127
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~29.61 miles north of Desoto
  • Three Star Suburban property
  • 60 suites in hotel
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From$69
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Holiday Inn St. Louis Sw Route 66 An Ihg Hotel 10709 Watson Rd., St. Louis, MO 63127
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~29.78 miles north of Desoto
  • 3 star Suburban hotel
  • Hotel has 12 suites
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From$79
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La Quinta Inn & Suites by Wyndham 1580 South Kirkwood Rd., Saint Louis, MO 63127
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~29.85 miles north of Desoto
  • Mid-scale Suburban property
  • Free breakfast
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From$100
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Best Western St. Louis-Kirkwood Route 66 1200 South Kirkwood Rd., Saint Louis, MO 63122
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~30.29 miles north of Desoto
  • Midscale Suburban hotel
  • Check in: 3pm
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From$70
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The Wildwood Hotel 2801 Fountain Place, Wildwood, MO 63040
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~30.75 miles north of Desoto
  • High end Suburban hotel
  • 110 sleeping rooms in hotel
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From$100
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Super 8 by Wyndham Union in Union 1015 East Main St., Union, MO 63084
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~31.92 miles northwest of Desoto
  • Economical Rural hotel
  • Check-in time: 11:00 AM
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From$67
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Courtyard by Marriott St. Louis West County - St. Louis 12815a Daylight Dr., St. Louis, MO 63131 Website
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~32.70 miles north of Desoto
  • Midscale Suburban hotel
  • Fitness + Health Center
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From$79
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Next: See My Desoto Hotels with Pricing

Graph: Upcoming 20 Days of Desoto Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Desoto, MO discounts available. The chart reflects the cheapest Desoto hotel for each day and each star rating category.

FAQs about hotels in Desoto

What are the top rated hotels in Desoto?

Holiday Inn Club Vac Timber Creek, Hampton Inn St. Louis Southwest and Holiday Inn Express Hotel & Suites Festus South St. Louis by Ih are the best rated hotels based on customer reviews in the last 365 days.

What are the most high-end hotels in Desoto?

The Wildwood Hotel, Holiday Inn Club Vac Timber Creek and Comfort Inn Festus St. Louis South are the top 3 luxury hotels near Desoto city center.

What hotels are closest to the city center of Desoto?

Holiday Inn Club Vac Timber Creek, Holiday Inn Express Hotel & Suites Festus South St. Louis by Ih, and Comfort Inn Festus St. Louis South are the properties closest to Desoto city center.

What are the most popular independent hotels in Desoto?

Pinemark Inn & Suites, The Wildwood Hotel and America's Best Inn Eureka are the best rated independent hotels (not part of a big brand).

What are the most popular Marriott hotels in Desoto?

Courtyard by Marriott St. Louis West County and Fairfield Inn N Ste St. Louis South are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the most popular Choice Hotels branded hotels in Desoto?

Comfort Inn Festus St. Louis South, Woodspring Suites St. Louis Arnold and Quality Inn Near Six Flags St. Louis are the best rated Choice Hotels branded hotels (based on HotelPlanner reviews score).

What are the most popular Best Western hotels in Desoto?

Crown Pointe Lodge, BW Signature Collection, Best Western St. Louis-Kirkwood Route 66 and Best Western St. Louis Inn are the best rated Best Western branded hotels (based on user reviews score).

What are the most popular IHG hotels in Desoto?

Holiday Inn Club Vac Timber Creek, Holiday Inn Express Hotel & Suites Festus South St. Louis by Ih and Holiday Inn Express & Suites Farmington by IHG are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

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