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Desoto Missouri Accommodations

Find hotels in Desoto using the list and search tools below. Search for the cheapest discounted hotel and motel rates in or near Desoto, MO for your corporate or personal leisure travel. We show the best Desoto Missouri hotel rooms. Review the Desoto hotel list below to find the perfect lodging. We also have a map of the Desoto hotels.

Desoto Hotels/Accommodations

Holiday Inn Club Vac Timber Creek 4800 Us Highway 67, Desoto, MO 63020
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  • Affordable hotel
  • Check in time: 16:00
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From$90
Very Good 4.5 /5 Review Score Call BookMore Details
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Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IH in Festus 1802 Gamel Cemetery Rd., Festus, MO 63028
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~9.28 miles northeast of Desoto
  • 2 star Highway hotel
  • Fitness + Health Center
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From$90
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Comfort Inn Festus St. Louis South - Festus 1303 Veterans Blvd., Festus, MO 63028 Website
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~9.48 miles northeast of Desoto
  • Midscale Suburban hotel
  • 5 suites in hotel
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From$45
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Baymont by Wyndham Festus - Festus 1200 West Gannon Dr., Festus, MO 63028
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~9.51 miles northeast of Desoto
  • 3 star Suburban hotel
  • 134 rooms in hotel
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From$72
Average 3.0 /5 Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham Festus - St. Louis South 1001 Veterans Blvd., Festus, MO 63028
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~9.70 miles northeast of Desoto
  • Mid-scale Suburban hotel
  • Check in: 3:00 PM
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From$80
Average 3.0 /5 Review Score Call BookMore Details
Super 8 by Wyndham Pevely 1711 Highway Z, Pevely, MO 63070
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~13.03 miles northeast of Desoto
  • Low Cost property
  • Check in: 11:00 AM
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From$35
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Super 8 by Wyndham Bonne Terre in Bonne Terre 8 Northwood Dr., Bonne Terre, MO 63628
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~14.93 miles south of Desoto
  • 2 star hotel
  • Check in time: 11:00 AM
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From$60
Average 3.0 /5 Hotel Reviews Call BookMore Details
Motel 6 Bonne Terre Mo - Bonne Terre 1017 Highway K, Bonne Terre, MO 63628
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~15.12 miles south of Desoto
  • Low Cost hotel
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From$60
Average 3.0 /5 Recent Reviews Call BookMore Details
Super 8 by Wyndham Potosi 820 East High St., Potosi, MO 63664
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~18.89 miles southwest of Desoto
  • Cheap Highway hotel
  • 48 rooms in property
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From$49
Average 3.0 /5 Latest Reviews Call BookMore Details
Quality Inn & Suites : 3610 West Outer Rd. 3610 West Outer Rd., Arnold, MO 63010 Website
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~20.97 miles northeast of Desoto
  • Low Cost Suburban hotel
  • Hotel has an eco-friendly policy Read more
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From$60
Average 3.0 /5 Latest Reviews Call BookMore Details
Woodspring Suites St. Louis Arnold 888 Arnold Commons Dr., Arnold, MO 63010
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~22.46 miles northeast of Desoto
  • Low Cost Highway hotel
  • 4 floors in hotel
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From$32
Very Good 4.0 /5 Read Reviews Call BookMore Details
Drury Inn & Suites St. Louis Arnold 3800 State Rt 141, Arnold, MO 63010
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~22.57 miles northeast of Desoto
  • 3 star Suburban property
  • Check-in time: 3:00 pm
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From$123
Excellent 5.0 /5 Hotel Reviews Call BookMore Details
Pear Tree Inn St. Louis Arnold - Arnold 1201 Drury Lane, Arnold, MO 63010
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~23.16 miles northeast of Desoto
  • 3-star Suburban property
  • Check-in time: 3:00 PM
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From$80
Very Good 4.0 /5 Reviews Call BookMore Details
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Crown Pointe Lodge, BW Signature Collection 4245 Hunt Rd., Farmington, MO 63640
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~23.27 miles south of Desoto
  • 3-star Golf Course hotel
  • Hotel has 48 rooms
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From$64
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Best Western St. Louis Inn in Saint Louis 6224 Heimos Industrial Park Dr., Saint Louis, MO 63129
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~24.42 miles northeast of Desoto
  • Economy Suburban property
  • Comp. Breakfast
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From$41
Average 3.0 /5 Hotel Reviews Call BookMore Details
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Hampton Inn Farmington - Farmington 850 Valley Creek Dr., Farmington, MO 63640
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~24.70 miles south of Desoto
  • Midscale Highway property
  • Free breakfast
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From$80
Average 3.0 /5 Review Score Call BookMore Details
Super 8 by Wyndham Farmington 930 Valley Creek Dr., Farmington, MO 63640
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~24.77 miles south of Desoto
  • Cheap hotel
  • 2 floors in property
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From$49
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Holiday Inn Express & Suites Farmington by IHG 820 Market St., Farmington, MO 63640
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~24.80 miles south of Desoto
  • Affordable Rural property
  • 3 floors in hotel
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From$99
Very Good 4.0 /5 Recent Reviews Call BookMore Details
680 Fenton Business Park Ct Fenton Missouri 63026 in Fenton Fenton Business Park Court Fenton, Fenton, IA 63026
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~25.48 miles north of Desoto
  • 3 star hotel
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From$80
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Quality Inn Farmington - Farmington 1400 West Liberty St., Farmington, MO 63640
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~25.62 miles south of Desoto
  • 3-star Rural property
  • 48 sleeping rooms in hotel
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From$80
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America's Best Inn Eureka 1725 West 5th St., Eureka, MO 63025
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~25.87 miles north of Desoto
  • Cheap Highway hotel
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From$60
Poor 2.0 /5 Read Reviews Call BookMore Details
Super 8 by Wyndham Eureka/Six Flags Nearby in Eureka 1733 West 5th St., Eureka, MO 63025
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~25.94 miles north of Desoto
  • Inexpensive Highway property
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From$60
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Baymont Inn and Suites by Wyndham Farmington, MO : 1625 West Columbia St. 1625 West Columbia St., Farmington, MO 63640
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~25.97 miles south of Desoto
  • Three Star Highway property
  • 3 conference rooms in property
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From$80
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Fairfield Inn N Ste St. Louis South 4318 Butler Hill Rd., St Louis, MO 63128
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~26.09 miles northeast of Desoto
  • Midscale hotel
  • 77 sleeping rooms in hotel
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From$90
Average 3.0 /5 Latest Reviews Call BookMore Details
Holiday Inn Express & Suites St. Louis South I 55 by IHG 4250 Midamerica Ln, St. Louis, MO 63129
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~26.13 miles northeast of Desoto
  • Three Star Suburban property
  • 17 suites in hotel
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From$80
Average 3.0 /5 Recent Reviews Call BookMore Details
Quality Inn Near Six Flags St. Louis : 1400 West Osage St. 1400 West Osage St., Pacific, MO 63069
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~26.17 miles northwest of Desoto
  • Affordable Rural property
  • Hotel has 46 rooms
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From$80
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Hampton Inn & Suites St. Louis/South I-55 - St. Louis 4200 Midamerica Ln, St. Louis, MO 63129
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~26.18 miles northeast of Desoto
  • Midscale Suburban hotel
  • Hotel has 33 suites
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From$80
Very Good 4.0 /5 Reviews Call BookMore Details
Comfort Inn Near Six Flags St. Louis 1320 Thornton St., Pacific, MO 63069 Website
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~26.28 miles northwest of Desoto
  • Mid-scale Highway hotel
  • Check in: 3:00PM
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From$88
Average 3.0 /5 Reviews Call BookMore Details
Holiday Inn St. Louis West Six Flags by IHG 4901 Six Flags Rd., Eureka, MO 63025
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~26.41 miles north of Desoto
  • Three Star Suburban hotel
  • Check-in: 04:00pm
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From$129
Average 3.0 /5 Recent Reviews Call BookMore Details
Super 8 by Wyndham Waterloo : 112 Warren Dr. 112 Warren Dr., Waterloo, IL 62298
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~26.68 miles northeast of Desoto
  • Economical Rural hotel
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From$60
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Super 8 by Wyndham St. Clair MO in Saint Clair 1010 South Outer Rd., Saint Clair, MO 63077
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~27.53 miles northwest of Desoto
  • Two-star Highway property
  • 2 suites in hotel
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From$60
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Pinemark Inn & Suites in St. Clair 866 South Outer Rd., St. Clair, MO 63077
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~27.60 miles northwest of Desoto
  • Economy Highway hotel
  • Hotel has 3 suites
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From$61
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Hampton Inn St. Louis Southwest in St. Louis 9 Lambert Drury Place, St. Louis, MO 63088
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~27.66 miles north of Desoto
  • Mid-scale Suburban property
  • Check-in time: 03:00 PM
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From$85
Very Good 4.5 /5 Reviews Call BookMore Details
Drury Inn & Suites St. Louis Southwest : 5 Lambert Drury Place (I 44 & 141) 5 Lambert Drury Place (I 44 & 141), St. Louis, MO 63088
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~27.66 miles north of Desoto
  • 3 star Suburban hotel
  • Check-in: 3:00 PM
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From$84
Very Good 4.5 /5 Guest Reviews Call BookMore Details
Hampton Inn St. Louis Columbia : 165 Admiral Trost Dr. 165 Admiral Trost Dr., Columbia, IL 62236
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~27.76 miles northeast of Desoto
  • 3 star Suburban hotel
  • Hotel has 3 floors
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From$80
Average 3.0 /5 Latest Reviews Call BookMore Details
Holiday Inn Express & Suites St. Louis West - Fenton by IHG : 1848 Bowles Ave. 1848 Bowles Ave., Fenton, MO 63026
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~27.97 miles north of Desoto
  • Three Star Suburban property
  • Check-in: 03:00 PM
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From$80
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Motel 6 Fenton Mo - Fenton 1860 Bowles Ave., Fenton, MO 63026
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~27.99 miles north of Desoto
  • Low priced hotel
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From$60
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Wingate by Wyndham St. Louis / Fenton Route 66 : 1100 South Highway Dr. 1100 South Highway Dr., Fenton, MO 63026
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~28.11 miles north of Desoto
  • Three Star Suburban property
  • Has environment-friendly policy See policy
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From$80
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Heritage Inn & Suites St. Louis / Fenton Trademark by Wyndham 1088 South Highway Dr., Fenton, MO 63026
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~28.17 miles north of Desoto
  • Mid-scale Suburban hotel
  • Access to gym on-site
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From$80
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Extended Stay America Suites St. Louis Fenton : 1662 Fenton Business Park Court 1662 Fenton Business Park Court, Fenton, MO 63026
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~28.25 miles north of Desoto
  • Affordable Suburban property
  • Free complimentary breakfast
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From$80
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Americas Best Value Inn St. Louis South 6602 South Lindbergh Blvd., St. Louis, MO 63123
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~28.28 miles northeast of Desoto
  • Two-star Suburban hotel
  • Hotel has 3 floors
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From$49
Poor 2.0 /5 Reviews Call BookMore Details
Best Western Plus Fenton 1680 Fenton Business Park Court, Fenton, MO 63026
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~28.32 miles north of Desoto
  • 3-star Suburban property
  • Hotel has 21 suites
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From$64
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Super 8 by Wyndham Fenton/St. Louis Area - Fenton 650 South Highway Dr., Fenton, MO 63026
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~28.34 miles north of Desoto
  • Economical property
  • Check in: 15:00
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From$60
Poor 2.0 /5 Guest Reviews Call BookMore Details
Aviator Hotel & Suites 6921 South Lindbergh Blvd., St Louis, MO 63125
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~28.36 miles northeast of Desoto
  • Affordable Suburban property
  • Check-in time: 04:00
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From$80
Average 3.0 /5 Recent Reviews Call BookMore Details
Comfort Suites St. Louis : 3654 South Lindbergh Blvd. 3654 South Lindbergh Blvd., St. Louis, MO 63127
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~29.13 miles north of Desoto
  • Low priced Suburban property
  • Has environment-friendly policy See policy
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From$49
Average 3.5 /5 Guest Reviews Call BookMore Details
Microtel Inn & Suites by Wyndham Sainte Genevieve 21958 State Highway 32, Ste. Genevieve, MO 63670
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~29.55 miles east of Desoto
  • Economical Highway hotel
  • Hotel has 2 floors
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From$50
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Days Inn by Wyndham St. Louis Lindbergh Boulevard 3660 South Lindbergh Blvd., St Louis, MO 63127
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~29.61 miles north of Desoto
  • Affordable Suburban property
  • Comp. Breakfast
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From$69
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Holiday Inn St. Louis Sw Route 66 An Ihg Hotel - St. Louis 10709 Watson Rd., St. Louis, MO 63127
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~29.78 miles north of Desoto
  • Midscale Suburban hotel
  • 213 rooms in property
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From$79
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La Quinta Inn & Suites by Wyndham 1580 South Kirkwood Rd., Saint Louis, MO 63127
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~29.85 miles north of Desoto
  • Three Star Suburban hotel
  • Access to gym on-site
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From$100
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Best Western St. Louis-Kirkwood Route 66 - Saint Louis 1200 South Kirkwood Rd., Saint Louis, MO 63122
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~30.29 miles north of Desoto
  • 3-star Suburban hotel
  • 113 sleeping rooms in hotel
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From$70
Very Good 4.0 /5 Hotel Reviews Call BookMore Details

Next: See My Desoto Hotels with Pricing

Graph: Upcoming 20 Days of Desoto Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Desoto, MO discounts available. The chart reflects the cheapest Desoto hotel for each day and each star rating category.

FAQs about hotels in Desoto

What are the top reviewed hotels in Desoto?

Drury Inn & Suites St. Louis Arnold, Holiday Inn Club Vac Timber Creek and Hampton Inn St. Louis Southwest are the best rated hotels based on customer reviews in the last 365 days.

What are the top luxurious hotels in Desoto?

Holiday Inn Club Vac Timber Creek, Comfort Inn Festus St. Louis South and Baymont by Wyndham Festus are the top 3 luxury hotels near Desoto city center.

What hotels are closest to the city center of Desoto?

Holiday Inn Club Vac Timber Creek, Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IH, and Comfort Inn Festus St. Louis South are the properties closest to Desoto city center.

What are the most popular independent hotels in Desoto?

Pinemark Inn & Suites, America's Best Inn Eureka and 680 Fenton Business Park Ct Fenton Missouri 63026 are the best rated independent hotels (not part of a big brand).

What are the most popular Choice Hotels branded hotels in Desoto?

Comfort Inn Festus St. Louis South, Woodspring Suites St. Louis Arnold and Quality Inn Near Six Flags St. Louis are the best rated Choice Hotels branded hotels (based on HotelPlanner reviews score).

What are the most popular Best Western hotels in Desoto?

Crown Pointe Lodge, BW Signature Collection, Best Western St. Louis-Kirkwood Route 66 and Best Western St. Louis Inn are the best rated Best Western branded hotels (based on user reviews score).

What are the most popular IHG hotels in Desoto?

Holiday Inn Club Vac Timber Creek, Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IH and Holiday Inn Express & Suites Farmington by IHG are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

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