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Desoto Missouri Accommodations

Find hotels in Desoto using the list and search tools below. Search for the cheapest discounted hotel and motel rates in or near Desoto, MO for your corporate or personal leisure travel. We show the best Desoto Missouri hotel rooms. Review the Desoto hotel list below to find the perfect lodging. We also have a map of the Desoto hotels.

Desoto Hotels, Motels & Accommodations

Holiday Inn Club Vac Timber Creek - Desoto 4800 Us Highway 67, Desoto, MO 63020
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  • 3 star property
  • Hotel has 3 floors
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From$108 total
Very Good 4.5 /5 Recent Reviews Call BookMore Details
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Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IH - Festus 1802 Gamel Cemetery Rd., Festus, MO 63028
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~9.28 miles northeast of Desoto
  • Two-star Highway hotel
  • 85 rooms in property
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From$108 total
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Comfort Inn Festus : 1303 Veterans Blvd. 1303 Veterans Blvd., Festus, MO 63028 Website
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~9.48 miles northeast of Desoto
  • 3 star Suburban hotel
  • Check-in: 3:00 PM
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From$96 total
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Baymont by Wyndham Festus : 1200 West Gannon Dr. 1200 West Gannon Dr., Festus, MO 63028
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~9.51 miles northeast of Desoto
  • 3 star Suburban property
  • 7 meeting rooms in property
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From$86 total
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La Quinta Inn & Suites by Wyndham Festus - St. Louis South - Festus 1001 Veterans Blvd., Festus, MO 63028
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~9.70 miles northeast of Desoto
  • 3 star Suburban property
  • Comp. Breakfast
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From$96 total
Average 3.0 /5 Recent Reviews Call BookMore Details
Super 8 by Wyndham Pevely in Pevely 1711 Highway Z, Pevely, MO 63070
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~13.03 miles northeast of Desoto
  • Low Cost hotel
  • Check-in: 11:00 AM
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From$42 total
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Super 8 by Wyndham Bonne Terre 8 Northwood Dr., Bonne Terre, MO 63628
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~14.93 miles south of Desoto
  • Inexpensive hotel
  • Check-in time: 11:00 AM
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From$72 total
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Motel 6 Bonne Terre Mo 1017 Highway K, Bonne Terre, MO 63628
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~15.12 miles south of Desoto
  • Cheap hotel
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From$72 total
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Super 8 by Wyndham Potosi 820 East High St., Potosi, MO 63664
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~18.89 miles southwest of Desoto
  • Low-priced Highway property
  • Hotel has 2 floors
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From$58 total
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Quality Inn & Suites 3610 West Outer Rd., Arnold, MO 63010
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~20.97 miles northeast of Desoto
  • Low-priced Suburban property
  • Gym is available on property
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From$72 total
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Woodspring Suites St. Louis Arnold 888 Arnold Commons Dr., Arnold, MO 63010
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~22.46 miles northeast of Desoto
  • Two-star Highway hotel
  • Hotel has 124 rooms
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From$38 total
Very Good 4.0 /5 Review Score Call BookMore Details
Crown Pointe Lodge, BW Signature Collection in Farmington 4245 Hunt Rd., Farmington, MO 63640
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~23.27 miles south of Desoto
  • 3 star Golf Course hotel
  • Check in time: 04:00
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From$76 total
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Best Western St. Louis Inn 6224 Heimos Industrial Park Dr., Saint Louis, MO 63129
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~24.42 miles northeast of Desoto
  • Two-star Suburban hotel
  • Check-in time: 03:00
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From$49 total
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Hampton Inn Farmington : 850 Valley Creek Dr. 850 Valley Creek Dr., Farmington, MO 63640
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~24.70 miles south of Desoto
  • 3 star Highway hotel
  • 3 floors in hotel
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From$96 total
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Super 8 by Wyndham Farmington 930 Valley Creek Dr., Farmington, MO 63640
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~24.77 miles south of Desoto
  • Economical hotel
  • Free breakfast
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From$58 total
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Holiday Inn Express & Suites Farmington by IHG : 820 Market St. 820 Market St., Farmington, MO 63640
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~24.80 miles south of Desoto
  • Affordable Rural hotel
  • 3 floors in property
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From$118 total
Very Good 4.0 /5 Latest Reviews Call BookMore Details
680 Fenton Business Park Ct Fenton Missouri 63026 : Fenton Business Park Court Fenton Fenton Business Park Court Fenton, Fenton, IA 63026
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~25.48 miles north of Desoto
  • 3 star hotel
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From$96 total
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Quality Inn Farmington in Farmington 1400 West Liberty St., Farmington, MO 63640
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~25.62 miles south of Desoto
  • 3 star Rural property
  • Check in: 11:00
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From$96 total
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America's Best Inn Eureka 1725 West 5th St., Eureka, MO 63025
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~25.87 miles north of Desoto
  • Economy Highway property
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From$72 total
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Super 8 by Wyndham Eureka/Six Flags Nearby in Eureka 1733 West 5th St., Eureka, MO 63025
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~25.94 miles north of Desoto
  • 2-star Highway hotel
  • Check in: ex. 3:00 PM
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From$72 total
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Baymont Inn and Suites by Wyndham Farmington, MO 1625 West Columbia St., Farmington, MO 63640
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~25.97 miles south of Desoto
  • 3 star Highway property
  • Check in: 04:00
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From$96 total
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Fairfield Inn N Ste St. Louis South 4318 Butler Hill Rd., St Louis, MO 63128
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~26.09 miles northeast of Desoto
  • Midscale hotel
  • Hotel has 77 rooms
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From$108 total
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Holiday Inn Express & Suites St. Louis South I 55 by IHG 4250 Midamerica Ln, St. Louis, MO 63129
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~26.13 miles northeast of Desoto
  • 3 star Suburban property
  • Hotel has 2 meeting rooms
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From$96 total
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Quality Inn Near Six Flags St. Louis 1400 West Osage St., Pacific, MO 63069
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~26.17 miles northwest of Desoto
  • 3-star Rural hotel
  • 46 sleeping rooms in hotel
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From$96 total
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Hampton Inn & Suites St. Louis/South I-55 in St. Louis 4200 Midamerica Ln, St. Louis, MO 63129
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~26.18 miles northeast of Desoto
  • Mid-scale Suburban hotel
  • 33 suites in property
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From$96 total
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Comfort Inn Near Six Flags St. Louis 1320 Thornton St., Pacific, MO 63069
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~26.28 miles northwest of Desoto
  • Affordable Highway hotel
  • Check-in time: 3:00PM
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From$105 total
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Holiday Inn St. Louis West Six Flags by IHG : 4901 Six Flags Rd. 4901 Six Flags Rd., Eureka, MO 63025
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~26.41 miles north of Desoto
  • 3-star Suburban hotel
  • Check-in time: 04:00pm
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From$154 total
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Super 8 by Wyndham Waterloo 112 Warren Dr., Waterloo, IL 62298
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~26.68 miles northeast of Desoto
  • Low priced Rural property
  • Check in time: 3:00 PM
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From$72 total
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Super 8 by Wyndham St. Clair MO 1010 South Outer Rd., Saint Clair, MO 63077
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~27.53 miles northwest of Desoto
  • 2 star Highway hotel
  • Check in time: 3 PM
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From$72 total
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Pinemark Inn & Suites 866 South Outer Rd., St. Clair, MO 63077
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~27.60 miles northwest of Desoto
  • Two-star Highway hotel
  • 3 suites in property
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From$73 total
Very Good 4.0 /5 Review Score Call BookMore Details
Hampton Inn St. Louis Southwest in St. Louis 9 Lambert Drury Place, St. Louis, MO 63088
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~27.66 miles north of Desoto
  • 3-star Suburban property
  • Free breakfast available
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From$102 total
Very Good 4.5 /5 Review Score Call BookMore Details
Hampton Inn St. Louis Columbia 165 Admiral Trost Dr., Columbia, IL 62236
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~27.76 miles northeast of Desoto
  • Three Star Suburban property
  • 3 floors in property
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From$96 total
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Holiday Inn Express & Suites St. Louis West - Fenton by IHG in Fenton 1848 Bowles Ave., Fenton, MO 63026
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~27.97 miles north of Desoto
  • Three Star Suburban property
  • 76 sleeping rooms in hotel
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From$96 total
Very Good 4.0 /5 Review Score Call BookMore Details
Motel 6 Fenton Mo - Fenton 1860 Bowles Ave., Fenton, MO 63026
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~27.99 miles north of Desoto
  • Two-star property
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From$72 total
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Wingate by Wyndham St. Louis / Fenton Route 66 : 1100 South Highway Dr. 1100 South Highway Dr., Fenton, MO 63026
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~28.11 miles north of Desoto
  • 3-star Suburban hotel
  • Free comp. breakfast
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From$96 total
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Heritage Inn & Suites St. Louis / Fenton Trademark by Wyndham in Fenton 1088 South Highway Dr., Fenton, MO 63026
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~28.17 miles north of Desoto
  • Three Star Suburban property
  • Fitness center on property
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From$96 total
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Extended Stay America Suites St. Louis Fenton 1662 Fenton Business Park Court, Fenton, MO 63026
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~28.25 miles north of Desoto
  • Three Star Suburban property
  • 3 floors in property
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From$96 total
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Americas Best Value Inn St. Louis South - St. Louis 6602 South Lindbergh Blvd., St. Louis, MO 63123
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~28.28 miles northeast of Desoto
  • Two star Suburban property
  • Hotel has 95 rooms
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From$58 total
Poor 2.0 /5 Guest Reviews Call BookMore Details
Best Western Plus Fenton - Fenton 1680 Fenton Business Park Court, Fenton, MO 63026
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~28.32 miles north of Desoto
  • Three Star Suburban property
  • Hotel has 102 rooms
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From$76 total
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Super 8 by Wyndham Fenton/St. Louis Area 650 South Highway Dr., Fenton, MO 63026
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~28.34 miles north of Desoto
  • Low-priced property
  • Check-in: 15:00
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From$72 total
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Aviator Hotel & Suites in St Louis 6921 South Lindbergh Blvd., St Louis, MO 63125
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~28.36 miles northeast of Desoto
  • 3-star Suburban hotel
  • 149 sleeping rooms in hotel
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From$96 total
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Comfort Suites St. Louis in St. Louis 3654 South Lindbergh Blvd., St. Louis, MO 63127
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~29.13 miles north of Desoto
  • Low-priced Suburban property
  • Hotel has 3 meeting rooms
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From$58 total
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Microtel Inn & Suites by Wyndham Sainte Genevieve - Ste. Genevieve 21958 State Highway 32, Ste. Genevieve, MO 63670
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~29.55 miles east of Desoto
  • Two star Highway property
  • Check-in time: 3:00 pm
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From$60 total
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Days Inn by Wyndham St. Louis Lindbergh Boulevard 3660 South Lindbergh Blvd., St Louis, MO 63127
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~29.61 miles north of Desoto
  • 3-star Suburban hotel
  • 116 rooms in property
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From$82 total
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Holiday Inn St. Louis Sw Route 66 An Ihg Hotel : 10709 Watson Rd. 10709 Watson Rd., St. Louis, MO 63127
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~29.78 miles north of Desoto
  • Three Star Suburban hotel
  • Check in time: 4:00 PM
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From$94 total
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La Quinta Inn & Suites by Wyndham - Saint Louis 1580 South Kirkwood Rd., Saint Louis, MO 63127
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~29.85 miles north of Desoto
  • Affordable Suburban hotel
  • Hotel has 3 floors
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From$120 total
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Best Western St. Louis-Kirkwood Route 66 1200 South Kirkwood Rd., Saint Louis, MO 63122
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~30.29 miles north of Desoto
  • 3 star Suburban hotel
  • Free breakfast
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From$84 total
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The Wildwood Hotel : 2801 Fountain Place 2801 Fountain Place, Wildwood, MO 63040
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~30.75 miles north of Desoto
  • Four-star Suburban hotel
  • 110 sleeping rooms in hotel
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From$120 total
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Super 8 by Wyndham Union : 1015 East Main St. 1015 East Main St., Union, MO 63084
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~31.92 miles northwest of Desoto
  • Low priced Rural hotel
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From$80 total
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Courtyard by Marriott St. Louis West County 12815a Daylight Dr., St. Louis, MO 63131 Website
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~32.70 miles north of Desoto
  • Affordable Suburban property
  • Check-in: 3pm
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From$94 total
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Next: See My Desoto Hotels with Pricing

Graph: Upcoming 20 Days of Desoto Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Desoto, MO discounts available. The chart reflects the cheapest Desoto hotel for each day and each star rating category.

FAQs about hotels in Desoto

What are the top rated hotels in Desoto?

Holiday Inn Club Vac Timber Creek, Hampton Inn St. Louis Southwest and Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IH are the best rated hotels based on customer reviews in the last 365 days.

What are the most high-end hotels in Desoto?

The Wildwood Hotel, Holiday Inn Club Vac Timber Creek and Comfort Inn Festus are the top 3 luxury hotels near Desoto city center.

What hotels are closest to the city center of Desoto?

Holiday Inn Club Vac Timber Creek, Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IH, and Comfort Inn Festus are the properties closest to Desoto city center.

What are the most popular independent hotels in Desoto?

Pinemark Inn & Suites, The Wildwood Hotel and America's Best Inn Eureka are the best rated independent hotels (not part of a big brand).

What are the most popular Marriott hotels in Desoto?

Courtyard by Marriott St. Louis West County and Fairfield Inn N Ste St. Louis South are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the best Choice Hotels branded hotels in Desoto?

Woodspring Suites St. Louis Arnold, Quality Inn Near Six Flags St. Louis and Comfort Suites St. Louis are the best rated Choice Hotels branded hotels (based on HotelPlanner reviews score).

What are the most popular Best Western hotels in Desoto?

Crown Pointe Lodge, BW Signature Collection, Best Western St. Louis-Kirkwood Route 66 and Best Western St. Louis Inn are the best rated Best Western branded hotels (based on user reviews score).

What are the most popular IHG hotels in Desoto?

Holiday Inn Club Vac Timber Creek, Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IH and Holiday Inn Express & Suites Farmington by IHG are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

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