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Desoto Missouri Accommodations

Find hotels in Desoto using the list and search tools below. Search for the cheapest discounted hotel and motel rates in or near Desoto, MO for your corporate or personal leisure travel. We show the best Desoto Missouri hotel rooms. Review the Desoto hotel list below to find the perfect lodging. We also have a map of the Desoto hotels.

Desoto Hotels/Motels & Accommodations

Holiday Inn Club Vac Timber Creek in Desoto 4800 Us Highway 67, Desoto, MO 63020
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  • Three Star hotel
  • Hotel has a green policy See policy
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From£79 total
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Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IH - Festus 1802 Gamel Cemetery Rd., Festus, MO 63028
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~9.28 miles northeast of Desoto
  • 2 star Highway hotel
  • Comp. Breakfast
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From£79 total
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Comfort Inn Festus 1303 Veterans Blvd., Festus, MO 63028 Website
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~9.48 miles northeast of Desoto
  • Affordable Suburban hotel
  • 3 floors in property
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From£70 total
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Baymont by Wyndham Festus 1200 West Gannon Dr., Festus, MO 63028
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~9.51 miles northeast of Desoto
  • 3 star Suburban hotel
  • Gym is available on property
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From£63 total
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La Quinta Inn & Suites by Wyndham Festus - St. Louis South 1001 Veterans Blvd., Festus, MO 63028
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~9.70 miles northeast of Desoto
  • 3 star Suburban property
  • Free breakfast
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From£70 total
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Super 8 by Wyndham Pevely 1711 Highway Z, Pevely, MO 63070
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~13.03 miles northeast of Desoto
  • Economy hotel
  • Check-in time: 11:00 AM
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From£31 total
Very good 4.0 /5 Latest Reviews Call BookMore Details
Super 8 by Wyndham Bonne Terre : 8 Northwood Dr. 8 Northwood Dr., Bonne Terre, MO 63628
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~14.93 miles south of Desoto
  • Inexpensive property
  • Check-in time: 11:00 AM
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From£53 total
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Motel 6 Bonne Terre Mo - Bonne Terre 1017 Highway K, Bonne Terre, MO 63628
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~15.12 miles south of Desoto
  • Economy property
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From£53 total
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Super 8 by Wyndham Potosi - Potosi 820 East High St., Potosi, MO 63664
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~18.89 miles southwest of Desoto
  • Inexpensive Highway property
  • Complimentary breakfast is offered
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From£43 total
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Quality Inn & Suites : 3610 West Outer Rd. 3610 West Outer Rd., Arnold, MO 63010
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~20.97 miles northeast of Desoto
  • 2 star Suburban property
  • Gym / Fitness Center Available
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From£53 total
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Woodspring Suites St. Louis Arnold in Arnold 888 Arnold Commons Dr., Arnold, MO 63010
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~22.46 miles northeast of Desoto
  • Low Cost Highway hotel
  • Check-in time: 3 p.m.
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From£28 total
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Crown Pointe Lodge, BW Signature Collection 4245 Hunt Rd., Farmington, MO 63640
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~23.27 miles south of Desoto
  • Affordable Golf Course hotel
  • 48 rooms in property
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From£54 total
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Best Western St. Louis Inn : 6224 Heimos Industrial Park Dr. 6224 Heimos Industrial Park Dr., Saint Louis, MO 63129
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~24.42 miles northeast of Desoto
  • Economy Suburban hotel
  • 3 floors in property
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From£35 total
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Hampton Inn Farmington - Farmington 850 Valley Creek Dr., Farmington, MO 63640
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~24.70 miles south of Desoto
  • Midscale Highway property
  • 6 meeting rooms in hotel
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From£70 total
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Super 8 by Wyndham Farmington - Farmington 930 Valley Creek Dr., Farmington, MO 63640
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~24.77 miles south of Desoto
  • Economy hotel
  • Complimentary breakfast is offered
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From£43 total
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Holiday Inn Express & Suites Farmington by IHG in Farmington 820 Market St., Farmington, MO 63640
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~24.80 miles south of Desoto
  • Affordable Rural property
  • Hotel has 60 rooms
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From£87 total
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680 Fenton Business Park Ct Fenton Missouri 63026 Fenton Business Park Court Fenton, Fenton, IA 63026
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~25.48 miles north of Desoto
  • 3 star hotel
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From£70 total
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Quality Inn Farmington in Farmington 1400 West Liberty St., Farmington, MO 63640
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~25.62 miles south of Desoto
  • 3-star Rural property
  • 48 rooms in property
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From£70 total
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America's Best Inn Eureka 1725 West 5th St., Eureka, MO 63025
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~25.87 miles north of Desoto
  • Economy Highway property
  • Check in time: 11.00am
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From£53 total
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Super 8 by Wyndham Eureka/Six Flags Nearby in Eureka 1733 West 5th St., Eureka, MO 63025
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~25.94 miles north of Desoto
  • Low priced Highway hotel
  • Free comp. breakfast
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From£53 total
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Baymont Inn and Suites by Wyndham Farmington, MO 1625 West Columbia St., Farmington, MO 63640
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~25.97 miles south of Desoto
  • Affordable Highway hotel
  • 2 floors in hotel
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From£70 total
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Fairfield Inn N Ste St. Louis South - St Louis 4318 Butler Hill Rd., St Louis, MO 63128
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~26.09 miles northeast of Desoto
  • Mid-scale property
  • 77 sleeping rooms in hotel
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From£79 total
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Holiday Inn Express & Suites St. Louis South I 55 by IHG - St. Louis 4250 Midamerica Ln, St. Louis, MO 63129
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~26.13 miles northeast of Desoto
  • Three Star Suburban property
  • Fitness / Gym is on-site
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From£70 total
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Quality Inn Near Six Flags St. Louis : 1400 West Osage St. 1400 West Osage St., Pacific, MO 63069
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~26.17 miles northwest of Desoto
  • 3 star Rural hotel
  • Check in time: 11:00
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From£70 total
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Hampton Inn & Suites St. Louis / South I 55 in St. Louis 4200 Midamerica Ln, St. Louis, MO 63129
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~26.18 miles northeast of Desoto
  • 3 star Suburban hotel
  • 92 sleeping rooms in hotel
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From£70 total
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Comfort Inn Near Six Flags St. Louis 1320 Thornton St., Pacific, MO 63069
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~26.28 miles northwest of Desoto
  • Midscale Highway hotel
  • 70 rooms in hotel
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From£77 total
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Holiday Inn St. Louis West Six Flags by IHG : 4901 Six Flags Rd. 4901 Six Flags Rd., Eureka, MO 63025
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~26.41 miles north of Desoto
  • Three Star Suburban hotel
  • 4 conference rooms in property
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From£114 total
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Super 8 by Wyndham Waterloo : 112 Warren Dr. 112 Warren Dr., Waterloo, IL 62298
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~26.68 miles northeast of Desoto
  • Two-star Rural hotel
  • Free complimentary breakfast
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From£53 total
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Super 8 by Wyndham St. Clair MO in Saint Clair 1010 South Outer Rd., Saint Clair, MO 63077
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~27.53 miles northwest of Desoto
  • Two star Highway hotel
  • Check-in: 3 PM
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From£53 total
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Pinemark Inn & Suites in St. Clair 866 South Outer Rd., St. Clair, MO 63077
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~27.60 miles northwest of Desoto
  • 2-star Highway hotel
  • Hotel has 3 suites
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From£54 total
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Hampton Inn St. Louis Southwest in St. Louis 9 Lambert Drury Place, St. Louis, MO 63088
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~27.66 miles north of Desoto
  • 3 star Suburban property
  • Fitness / Gym is on-site
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From£75 total
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Hampton Inn St. Louis Columbia 165 Admiral Trost Dr., Columbia, IL 62236
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~27.76 miles northeast of Desoto
  • 3 star Suburban property
  • Hotel has 3 floors
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From£70 total
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Holiday Inn Express & Suites St. Louis West - Fenton by IHG in Fenton 1848 Bowles Ave., Fenton, MO 63026
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~27.97 miles north of Desoto
  • 3-star Suburban property
  • 76 rooms in property
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From£70 total
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Motel 6 Fenton Mo 1860 Bowles Ave., Fenton, MO 63026
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~27.99 miles north of Desoto
  • Low-priced hotel
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From£53 total
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Wingate by Wyndham St. Louis / Fenton Route 66 : 1100 South Highway Dr. 1100 South Highway Dr., Fenton, MO 63026
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~28.11 miles north of Desoto
  • Affordable Suburban hotel
  • Check-in: 3:00 PM
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From£70 total
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Heritage Inn & Suites St. Louis / Fenton Trademark by Wyndham 1088 South Highway Dr., Fenton, MO 63026
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~28.17 miles north of Desoto
  • 3-star Suburban hotel
  • Free complimentary breakfast
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From£70 total
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Extended Stay America Suites St. Louis Fenton in Fenton 1662 Fenton Business Park Court, Fenton, MO 63026
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~28.25 miles north of Desoto
  • Affordable Suburban property
  • Free comp. breakfast
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From£70 total
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Americas Best Value Inn St. Louis South - St. Louis 6602 South Lindbergh Blvd., St. Louis, MO 63123
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~28.28 miles northeast of Desoto
  • Two-star Suburban hotel
  • 95 sleeping rooms in hotel
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From£43 total
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Best Western Plus Fenton 1680 Fenton Business Park Court, Fenton, MO 63026
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~28.32 miles north of Desoto
  • Midscale Suburban hotel
  • Check-in time: 03:00
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From£54 total
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Super 8 by Wyndham Fenton/St. Louis Area : 650 South Highway Dr. 650 South Highway Dr., Fenton, MO 63026
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~28.34 miles north of Desoto
  • Inexpensive property
  • Check-in: 15:00
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From£53 total
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Aviator Hotel & Suites 6921 South Lindbergh Blvd., St Louis, MO 63125
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~28.36 miles northeast of Desoto
  • Three Star Suburban hotel
  • Hotel has 6 suites
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From£70 total
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Comfort Suites St. Louis : 3654 South Lindbergh Blvd. 3654 South Lindbergh Blvd., St. Louis, MO 63127
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~29.13 miles north of Desoto
  • Economical Suburban property
  • 160 sleeping rooms in hotel
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From£43 total
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Microtel Inn & Suites by Wyndham Sainte Genevieve in Ste. Genevieve 21958 State Highway 32, Ste. Genevieve, MO 63670
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~29.55 miles east of Desoto
  • Economical Highway property
  • 6 suites in hotel
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From£44 total
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Days Inn by Wyndham St. Louis Lindbergh Boulevard : 3660 South Lindbergh Blvd. 3660 South Lindbergh Blvd., St Louis, MO 63127
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~29.61 miles north of Desoto
  • Affordable Suburban hotel
  • Hotel has 2 floors
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From£61 total
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Holiday Inn St. Louis Sw Route 66 An Ihg Hotel 10709 Watson Rd., St. Louis, MO 63127
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~29.78 miles north of Desoto
  • 3 star Suburban property
  • 12 suites in hotel
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From£69 total
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La Quinta Inn & Suites by Wyndham - Saint Louis 1580 South Kirkwood Rd., Saint Louis, MO 63127
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~29.85 miles north of Desoto
  • Three Star Suburban hotel
  • 3 floors in property
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From£88 total
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Best Western St. Louis-Kirkwood Route 66 - Saint Louis 1200 South Kirkwood Rd., Saint Louis, MO 63122
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~30.29 miles north of Desoto
  • Midscale Suburban property
  • Check-in: 3pm
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From£62 total
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The Wildwood Hotel in Wildwood 2801 Fountain Place, Wildwood, MO 63040
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~30.75 miles north of Desoto
  • 4 star Suburban hotel
  • Hotel has 18 suites
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From£88 total
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Super 8 by Wyndham Union - Union 1015 East Main St., Union, MO 63084
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~31.92 miles northwest of Desoto
  • 2-star Rural hotel
  • Complimentary breakfast is offered
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From£59 total
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Courtyard by Marriott St. Louis West County 12815a Daylight Dr., St. Louis, MO 63131 Website
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~32.70 miles north of Desoto
  • Mid-scale Suburban property
  • Gym / Fitness Center Available
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From£69 total
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Next: See My Desoto Hotels with Pricing

Graph: Upcoming 20 Days of Desoto Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Desoto, MO discounts available. The chart reflects the cheapest Desoto hotel for each day and each star rating category.

FAQs about hotels in Desoto

What are the top rated hotels in Desoto?

Holiday Inn Club Vac Timber Creek, Hampton Inn St. Louis Southwest and Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IH are the best rated hotels based on customer reviews in the last 365 days.

What are the most high-end hotels in Desoto?

The Wildwood Hotel, Holiday Inn Club Vac Timber Creek and Comfort Inn Festus are the top 3 luxury hotels near Desoto city center.

What hotels are closest to the city center of Desoto?

Holiday Inn Club Vac Timber Creek, Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IH, and Comfort Inn Festus are the properties closest to Desoto city center.

What are the most popular independent hotels in Desoto?

Pinemark Inn & Suites, The Wildwood Hotel and America's Best Inn Eureka are the best rated independent hotels (not part of a big brand).

What are the most popular Marriott hotels in Desoto?

Courtyard by Marriott St. Louis West County and Fairfield Inn N Ste St. Louis South are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the best Choice Hotels branded hotels in Desoto?

Woodspring Suites St. Louis Arnold, Quality Inn Near Six Flags St. Louis and Comfort Suites St. Louis are the best rated Choice Hotels branded hotels (based on HotelPlanner reviews score).

What are the most popular Best Western hotels in Desoto?

Crown Pointe Lodge, BW Signature Collection, Best Western St. Louis-Kirkwood Route 66 and Best Western St. Louis Inn are the best rated Best Western branded hotels (based on user reviews score).

What are the most popular IHG hotels in Desoto?

Holiday Inn Club Vac Timber Creek, Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IH and Holiday Inn Express & Suites Farmington by IHG are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

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