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Cairo Illinois Accommodations

Find hotels & motels in Cairo using the list below. Search for cheap and discounted hotel and motel rates in or close to Cairo, IL for your upcoming individual or group travel. Discover the best Cairo Illinois hotel/motel rooms. Review the Cairo hotel list below to find the perfect lodging. We also have a map of the Cairo hotels.

Cairo Hotels/Accommodations

Quality Inn Cairo I-57 13201 Kessler Rd., Cairo, IL 62914
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  • 3 star Highway property
  • 2 floors in hotel
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From$72 total
Poor 2.0 /5 Latest Reviews Call BookMore Details
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Super 8 by Wyndham Charleston/Sikeston East MO 310 South Story, Charleston, MO 63834
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~10.13 miles southwest of Cairo
  • Economy Highway property
  • 7 suites in hotel
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From$50 total
Average 3.5 /5 Hotel Reviews Call BookMore Details
The Riverstone Hotel Charleston-Sikeston - Charleston 102 Drake St., Charleston, MO 63834
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~11.88 miles southwest of Cairo
  • Two star Highway property
  • 2 floors in hotel
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From$70 total
Average 3.0 /5 Reviews Call BookMore Details
Americas Best Value Inn Ullin Mounds : 128 Cheekwood Lane 128 Cheekwood Lane, Ullin, IL 62992
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~17.88 miles north of Cairo
  • Low priced hotel
  • 40 rooms in hotel
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From$72 total
Average 3.0 /5 Guest Reviews Call BookMore Details
Motel 6 Sikeston Mo : 110 South Interstate Dr. 110 South Interstate Dr., SIKESTON, MO 63801
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~20.96 miles west of Cairo
  • 2 star property
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From$72 total
Average 3.0 /5 Reviews Call BookMore Details
Best Western Plus Sikeston in Sikeston 120 South Interstate Dr., Sikeston, MO 63801
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~21.00 miles west of Cairo
  • Low Cost Highway property
  • 55 rooms in hotel
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From$51 total
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Days Inn and Suites by Wyndham Sikeston in Sikeston 220 South Interstate Dr., Sikeston, MO 63801
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~21.07 miles west of Cairo
  • Cheap property
  • Check in time: 03:00 PM
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From$72 total
Average 3.0 /5 Review Score Call BookMore Details
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) in Sikeston 100 Matthews Lane, Sikeston, MO 63801
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~21.31 miles west of Cairo
  • Affordable Highway property
  • Free breakfast available
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From$96 total
Very Good 4.0 /5 Reviews Call BookMore Details
Super 8 by Wyndham Sikeston/Miner Area - Sikeston 2609 East Malone, Sikeston, MO 63801
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~21.32 miles west of Cairo
  • Low Cost Convention Center property
  • Free comp. breakfast
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From$72 total
Average 3.0 /5 Reviews Call BookMore Details
Comfort Inn : 109 Matthews Lane 109 Matthews Lane, Sikeston, MO 63801
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~21.34 miles west of Cairo
  • 3-star Highway hotel
  • Fitness / Gym is on-site
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From$102 total
Average 3.0 /5 Latest Reviews Call BookMore Details
Drury Inn & Suites Sikeston : 2608 East Malone Ave. 2608 East Malone Ave., Sikeston, MO 63801
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~21.37 miles west of Cairo
  • 3 star Highway hotel
  • Free breakfast
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From$124 total
Very Good 4.5 /5 Read Reviews Call BookMore Details
Pear Tree Inn Sikeston in Sikeston 2602 East Malone, Sikeston, MO 63801
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~21.38 miles west of Cairo
  • 3 star Suburban property
  • Free comp. breakfast
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From$96 total
Average 3.0 /5 Guest Reviews Call BookMore Details
Hampton Inn Sikeston - Sikeston 1240 Commerce Dr., Sikeston, MO 63801
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~24.48 miles west of Cairo
  • Three Star Rural property
  • 92 rooms in property
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From$96 total
Average 3.0 /5 Guest Reviews Call BookMore Details
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Holiday Inn Express & Suites Sikeston An Ihg Hotel in Sikeston 115 Hospitality Dr., Sikeston, MO 63801
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~24.49 miles west of Cairo
  • 3-star Rural hotel
  • Hotel has 3 floors
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From$96 total
Average 3.0 /5 Guest Reviews Call BookMore Details
Residence Inn by Marriott Paducah 3900 Coleman Crossing Circle, Paducah, KY 42001
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~25.66 miles east of Cairo
  • Midscale Suburban property
  • 2 meeting rooms in property
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From$106 total
Very Good 4.0 /5 Latest Reviews Call BookMore Details
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Pear Tree Inn Paducah : 5006 Hinkleville Rd. 5006 Hinkleville Rd., Paducah, KY 42001
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~25.77 miles east of Cairo
  • Two-star Suburban property
  • 59 rooms in hotel
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From$66 total
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destinatio : 100 East Front St. 100 East Front St., Metropolis, IL 62960
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~26.28 miles east of Cairo
  • Four-star hotel
  • Hotel has 252 rooms
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From$192 total
Very Good 4.0 /5 Read Reviews Call BookMore Details
Baymont by Wyndham Metropolis in Metropolis 203 East Front St., Metropolis, IL 62960
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~26.32 miles east of Cairo
  • 2 star Riverfront hotel
  • 8 suites in property
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From$54 total
Average 3.0 /5 Recent Reviews Call BookMore Details
Econo Lodge 1415 East 5th St., Metropolis, IL 62960
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~27.38 miles east of Cairo
  • Low priced hotel
  • Check-in: 11:00
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From$72 total
Not Good 1.0 /5 Hotel Reviews Call BookMore Details
 Econo Lodge Paducah West I-24 - Paducah 5120 Hinkleville Rd., Paducah, KY 42001
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~27.55 miles east of Cairo
  • Low-priced Airport hotel
  • 75 sleeping rooms in hotel
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From$72 total
Average 3.0 /5 Guest Reviews Call BookMore Details
Baymont by Wyndham Paducah in Paducah 5300 Old Cairo Rd., Paducah, KY 42001
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~27.64 miles east of Cairo
  • 3 star hotel
  • Check in: 15:00
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From$48 total
Poor 2.0 /5 Reviews Call BookMore Details
Courtyard by Marriott Cape Girardeau Downtown : 400 Broadway St. 400 Broadway St., Cape Girardeau, MO 63701
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~27.65 miles northwest of Cairo
  • Affordable Downtown property
  • Fitness / Gym is on-site
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From$96 total
Very Good 4.0 /5 Read Reviews Call BookMore Details
Drury Suites Paducah 2930 James Sanders Blvd., Paducah, KY 42001
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~27.70 miles east of Cairo
  • Three Star Suburban property
  • 6 floors in hotel
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From$118 total
Very Good 4.0 /5 Review Score Call BookMore Details
Quality Suites Paducah I-24 in Paducah 2880 James Sanders Blvd., Paducah, KY 42001 Website
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~27.73 miles east of Cairo
  • 2-star Highway hotel
  • Hotel has 2 floors
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From$72 total
Average 3.0 /5 Read Reviews Call BookMore Details
Comfort Inn & Suites near Six Flags in Lithia Springs 960 West Pointe Court, Lithia Springs, GA 30122 Website
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~27.80 miles east of Cairo
  • 3-star Downtown property
  • 2 floors in hotel
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From$84 total
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Garner Hotel Paducah West by IHG : 145 Mcbride Lane 145 Mcbride Lane, Paducah, KY 42001
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~27.80 miles east of Cairo
  • Affordable Highway hotel
  • 3 floors in hotel
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From$58 total
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Hotel 7 Inn Paducah 5001 Hinkleville Rd., Paducah, KY 42001
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~27.81 miles east of Cairo
  • Low-priced hotel
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From$72 total
Average 3.0 /5 Recent Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham Paducah 3960 Coleman Crossing Cir, Paducah, KY 42001
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~27.90 miles east of Cairo
  • Three Star Highway hotel
  • Hotel has a green policy Read more
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From$96 total
Average 3.0 /5 Review Score Call BookMore Details
Candlewood Suites Paducah by IHG 3940 Coleman Crossing Circle, Paducah, KY 42001
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~27.91 miles east of Cairo
  • Mid-scale Rural hotel
  • Hotel has 85 rooms
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From$72 total
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Homewood Suites by Hilton Paducah : 3925 Coleman Crossing Cir 3925 Coleman Crossing Cir, Paducah, KY 42001
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~27.94 miles east of Cairo
  • Mid-scale Highway property
  • 97 sleeping rooms in hotel
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From$130 total
Very Good 4.0 /5 Read Reviews Call BookMore Details
Comfort Suites 3918 Coleman Crossing Cir Paducah Ky 42001, Paducah, KY 42001
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~27.96 miles east of Cairo
  • Inexpensive Rural hotel
  • Hotel has 4 floors
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From$72 total
Average 3.0 /5 Hotel Reviews Call BookMore Details
Comfort Inn Paducah in Paducah 5135 Cairo Rd., Paducah, KY 42001
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~27.98 miles east of Cairo
  • Three Star hotel
  • Check-in: 3:00 PM
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From$70 total
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Fairfield Inn & Suites by Marriott Paducah 3950 Coleman Crossing Circle, Paducah, KY 42001
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~28.01 miles east of Cairo
  • Three Star Rural property
  • Hotel has 32 suites
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From$90 total
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Red Roof Inn Paducah 5106 Old Cairo Rd., Paducah, KY 42001
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~28.01 miles east of Cairo
  • 2-star property
  • 3 floors in hotel
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From$54 total
Average 3.5 /5 Review Score Call BookMore Details
American Inn 5125 Cairo Rd., Paducah, KY 42001
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~28.02 miles east of Cairo
  • Low-priced hotel
  • Check-in time: 14:00
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From$44 total
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Hampton Inn & Suites Paducah : 3901 Coleman Crossing Circle 3901 Coleman Crossing Circle, Paducah, KY 42001
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~28.02 miles east of Cairo
  • Mid-scale Highway hotel
  • Check-in time: 3:00 pm
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From$94 total
Very Good 4.5 /5 Read Reviews Call BookMore Details
Holiday Inn Express Hotel & Suites Paducah West by IHG 3996 Hinkleville Rd., Paducah, KY 42001
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~28.04 miles east of Cairo
  • Mid-scale Highway hotel
  • Check in: 3:00 PM
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From$96 total
Average 3.0 /5 Review Score Call BookMore Details
Auburn Place Hotel & Suites - Paducah : 3994 Hinkleville Rd. 3994 Hinkleville Rd., Paducah, KY 42001
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~28.05 miles east of Cairo
  • Affordable Airport hotel
  • Check-in time: 3:00 PM
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From$96 total
Very Good 4.0 /5 Review Score Call BookMore Details
Courtyard by Marriott Paducah 3835 Technology Dr., Paducah, KY 42001
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~28.29 miles east of Cairo
  • Mid-scale Suburban hotel
  • Access to gym on-site
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From$106 total
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Drury Inn Paducah : 3975 Hinkleville Rd. 3975 Hinkleville Rd., Paducah, KY 42001
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~28.70 miles east of Cairo
  • Affordable Suburban hotel
  • 113 sleeping rooms in hotel
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From$94 total
Very Good 4.5 /5 Guest Reviews Call BookMore Details
Days Inn by Wyndham Paducah I-24 Exit 4 - Paducah 3901 Hinkleville Rd., Paducah, KY 42001
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~28.75 miles east of Cairo
  • Two-star Highway hotel
  • 122 rooms in property
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From$60 total
Average 3.0 /5 Read Reviews Call BookMore Details
Candlewood Suites Cape Girardeau by IHG : 485 South Mount Auburn Rd. 485 South Mount Auburn Rd., Cape Girardeau, MO 65703
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~28.76 miles northwest of Cairo
  • Inexpensive Highway property
  • Check in time: 3:00PM
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From$82 total
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Travelers Inn and Suites - Paducah 2550 Lone Oak Rd., Paducah, KY 42003
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~28.88 miles east of Cairo
  • 2 star property
  • Airport shuttle provided
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From$45 total
Very Good 4.0 /5 Review Score Call BookMore Details
Quality Inn & Suites Metropolis I-24 - Metropolis 2118 East 5th St., Metropolis, IL 62960
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~28.88 miles east of Cairo
  • Affordable property
  • Check in time: 11:00
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From$96 total
Very Good 4.0 /5 Reviews Call BookMore Details
Super 8 by Wyndham Metropolis in Metropolis 2055 East 5th St., Metropolis, IL 62960
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~28.89 miles east of Cairo
  • Economy Highway property
  • 6 suites in property
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From$72 total
Average 3.0 /5 Read Reviews Call BookMore Details
Motel 6 Metropolis Il 2119 East 5th St., Metropolis, IL 62960
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~29.04 miles east of Cairo
  • 2 star property
  • Check-in: 11:00 AM
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From$72 total
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Holiday Inn Express Metropolis by IHG - Metropolis 2179 East 5th St., Metropolis, IL 62960
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~29.10 miles east of Cairo
  • Affordable Rural property
  • 75 rooms in property
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From$78 total
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Hampton Inn Cape Girardeau I 55 East in Cape Girardeau 207 South Mount Auburn Rd., Cape Girardeau, MO 63703
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~29.41 miles northwest of Cairo
  • Midscale Highway property
  • Check-in: 3:00 pm
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From$96 total
Excellent 5.0 /5 Guest Reviews Call BookMore Details
Victorian Inn & Suites 3256 William St., Cape Girardeau, MO 63703
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~29.41 miles northwest of Cairo
  • 3 star Golf Course hotel
  • 133 sleeping rooms in hotel
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From$94 total
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Auburn Place Hotel & Suites : 3265 Williams St. 3265 Williams St., Cape Girardeau, MO 63702
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~29.42 miles northwest of Cairo
  • 3-star Highway hotel
  • Complimentary breakfast is offered
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From$69 total
Very Good 4.5 /5 Latest Reviews Call BookMore Details

Next: See My Cairo Hotels with Pricing

Graph: Upcoming 20 Days of Cairo Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Cairo, IL discounts available. The chart reflects the cheapest Cairo hotel for each day and each star rating category.

FAQs about hotels in Cairo

What are the most favored hotels in Cairo?

Hampton Inn Cape Girardeau I 55 East, Drury Inn & Suites Sikeston and Hampton Inn & Suites Paducah are the best rated hotels based on customer reviews in the last 365 days.

What are the most luxurious hotels in Cairo?

Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destinatio, Quality Inn Cairo I-57 and Travel Inn & Suites - Sikeston are the top 3 luxury hotels near Cairo city center.

What hotels are closest to the city center of Cairo?

Quality Inn Cairo I-57, Super 8 by Wyndham Charleston, and The Riverstone Hotel Charleston-Sikeston are the properties closest to Cairo city center.

What are the best independent hotels in Cairo?

Auburn Place Hotel & Suites, Travel Inn & Suites - Sikeston and Drury Suites Paducah are the best rated independent hotels (not part of a big brand).

What are the most popular Marriott hotels in Cairo?

Residence Inn by Marriott Paducah, Courtyard by Marriott Cape Girardeau Downtown and Fairfield Inn & Suites by Marriott Paducah are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the best Choice Hotels branded hotels in Cairo?

Comfort Inn & Suites near Six Flags, Comfort Inn Paducah and Quality Inn & Suites Metropolis I-24 are the best rated Choice Hotels branded hotels (based on HotelPlanner reviews score).

What are the most popular IHG hotels in Cairo?

Candlewood Suites Paducah by IHG, Candlewood Suites Cape Girardeau by IHG and Holiday Inn Express Metropolis by IHG are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

Verified reviews of the city: Cairo, IL

Below are reviews of the city of Cairo, IL from an actual visitor's perspective.

"Spending time with my family"
Score 5.0 / 5

Vincent R., from 26-Jan-2026
The average traveler rating of the city of Cairo, IL shown above is 5.0 out of 5 based on 1 reviews
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