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Cairo Illinois Accommodations

Find hotels & motels in Cairo using the list below. Search for cheap and discounted hotel and motel rates in or close to Cairo, IL for your upcoming individual or group travel. Discover the best Cairo Illinois hotel/motel rooms. Review the Cairo hotel list below to find the perfect lodging. We also have a map of the Cairo hotels.

Cairo Hotels & Accommodations

Quality Inn Cairo I-57 in Cairo 13201 Kessler Rd., Cairo, IL 62914
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  • Affordable Highway property
  • Check-in time: 3 pm
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From$72 total
Poor 2.0 /5 Reviews Call BookMore Details
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Super 8 by Wyndham Charleston/Sikeston East MO 310 South Story, Charleston, MO 63834
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~10.13 miles southwest of Cairo
  • Cheap Highway hotel
  • Comp. Breakfast
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From$50 total
Average 3.5 /5 Latest Reviews Call BookMore Details
The Riverstone Hotel Charleston-Sikeston in Charleston 102 Drake St., Charleston, MO 63834
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~11.88 miles southwest of Cairo
  • 2-star Highway property
  • Fitness + Health Center
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From$70 total
Average 3.0 /5 Reviews Call BookMore Details
Americas Best Value Inn Ullin Mounds : 128 Cheekwood Lane 128 Cheekwood Lane, Ullin, IL 62992
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~17.88 miles north of Cairo
  • Economical hotel
  • Free breakfast available
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From$72 total
Average 3.0 /5 Hotel Reviews Call BookMore Details
Motel 6 Sikeston Mo 110 South Interstate Dr., SIKESTON, MO 63801
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~20.96 miles west of Cairo
  • Inexpensive hotel
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From$72 total
Average 3.0 /5 Recent Reviews Call BookMore Details
Best Western Plus Sikeston in Sikeston 120 South Interstate Dr., Sikeston, MO 63801
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~21.00 miles west of Cairo
  • Inexpensive Highway property
  • 2 floors in property
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From$50 total
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Days Inn and Suites by Wyndham Sikeston : 220 South Interstate Dr. 220 South Interstate Dr., Sikeston, MO 63801
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~21.07 miles west of Cairo
  • 2 star property
  • Check-in time: 03:00 PM
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From$72 total
Average 3.0 /5 Latest Reviews Call BookMore Details
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) 100 Matthews Lane, Sikeston, MO 63801
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~21.31 miles west of Cairo
  • 3 star Highway hotel
  • Hotel has 40 rooms
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From$96 total
Very Good 4.0 /5 Reviews Call BookMore Details
Super 8 by Wyndham Sikeston/Miner Area 2609 East Malone, Sikeston, MO 63801
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~21.32 miles west of Cairo
  • Low Cost Convention Center property
  • Free complimentary breakfast
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From$72 total
Average 3.0 /5 Recent Reviews Call BookMore Details
Comfort Inn - Sikeston 109 Matthews Lane, Sikeston, MO 63801
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~21.34 miles west of Cairo
  • Three Star Highway hotel
  • 64 sleeping rooms in hotel
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From$102 total
Average 3.0 /5 Reviews Call BookMore Details
Hampton Inn Sikeston : 1240 Commerce Dr. 1240 Commerce Dr., Sikeston, MO 63801
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~24.48 miles west of Cairo
  • Midscale Rural property
  • Gym / Fitness Center Available
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From$96 total
Average 3.0 /5 Reviews Call BookMore Details
Holiday Inn Express & Suites Sikeston An Ihg Hotel - Sikeston 115 Hospitality Dr., Sikeston, MO 63801
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~24.49 miles west of Cairo
  • Three Star Rural property
  • 3 floors in hotel
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From$96 total
Average 3.0 /5 Hotel Reviews Call BookMore Details
Residence Inn by Marriott Paducah 3900 Coleman Crossing Circle, Paducah, KY 42001
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~25.66 miles east of Cairo
  • Three Star Suburban property
  • Check in: 3:00PM
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From$106 total
Very Good 4.0 /5 Reviews Call BookMore Details
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Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destinatio : 100 East Front St. 100 East Front St., Metropolis, IL 62960
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~26.28 miles east of Cairo
  • High end hotel
  • Check-in time: 16:00
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From$192 total
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Baymont by Wyndham Metropolis 203 East Front St., Metropolis, IL 62960
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~26.32 miles east of Cairo
  • 2 star Riverfront property
  • Check in time: 3:00PM
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From$54 total
Average 3.0 /5 Read Reviews Call BookMore Details
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Econo Lodge : 1415 East 5th St. 1415 East 5th St., Metropolis, IL 62960
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~27.38 miles east of Cairo
  • Low Cost property
  • Check in time: 11:00
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From$72 total
Not Good 1.0 /5 Reviews Call BookMore Details
 Econo Lodge Paducah West I-24 5120 Hinkleville Rd., Paducah, KY 42001
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~27.55 miles east of Cairo
  • Two star Airport hotel
  • Hotel has 2 floors
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From$72 total
Average 3.0 /5 Read Reviews Call BookMore Details
Baymont by Wyndham Paducah - Paducah 5300 Old Cairo Rd., Paducah, KY 42001
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~27.64 miles east of Cairo
  • Mid-scale property
  • 74 rooms in hotel
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From$48 total
Poor 2.0 /5 Review Score Call BookMore Details
Courtyard by Marriott Cape Girardeau Downtown : 400 Broadway St. 400 Broadway St., Cape Girardeau, MO 63701
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~27.65 miles northwest of Cairo
  • Midscale Downtown hotel
  • 78 sleeping rooms in hotel
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From$96 total
Very Good 4.0 /5 Review Score Call BookMore Details
Quality Suites Paducah I-24 2880 James Sanders Blvd., Paducah, KY 42001 Website
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~27.73 miles east of Cairo
  • Two star Highway property
  • 59 suites in hotel
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From$72 total
Average 3.0 /5 Latest Reviews Call BookMore Details
Comfort Inn & Suites near Six Flags 960 West Pointe Court, Lithia Springs, GA 30122 Website
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~27.80 miles east of Cairo
  • 3 star Downtown hotel
  • Hotel has 60 rooms
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From$84 total
Very Good 4.0 /5 Read Reviews Call BookMore Details
Garner Hotel Paducah West by IHG 145 Mcbride Lane, Paducah, KY 42001
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~27.80 miles east of Cairo
  • 3-star Highway property
  • Gym / Fitness Center Available
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From$58 total
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Hotel 7 Inn Paducah : 5001 Hinkleville Rd. 5001 Hinkleville Rd., Paducah, KY 42001
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~27.81 miles east of Cairo
  • Low priced property
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From$72 total
Average 3.0 /5 Review Score Call BookMore Details
La Quinta Inn & Suites by Wyndham Paducah in Paducah 3960 Coleman Crossing Cir, Paducah, KY 42001
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~27.90 miles east of Cairo
  • Mid-scale Highway hotel
  • 4 floors in property
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From$96 total
Average 3.0 /5 Hotel Reviews Call BookMore Details
Candlewood Suites Paducah by IHG : 3940 Coleman Crossing Circle 3940 Coleman Crossing Circle, Paducah, KY 42001
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~27.91 miles east of Cairo
  • 3 star Rural hotel
  • 4 floors in property
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From$72 total
Very Good 4.0 /5 Reviews Call BookMore Details
Homewood Suites by Hilton Paducah 3925 Coleman Crossing Cir, Paducah, KY 42001
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~27.94 miles east of Cairo
  • Midscale Highway hotel
  • 4 floors in property
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From$130 total
Very Good 4.0 /5 Read Reviews Call BookMore Details
Comfort Suites in Paducah 3918 Coleman Crossing Cir Paducah Ky 42001, Paducah, KY 42001
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~27.96 miles east of Cairo
  • Cheap Rural property
  • 72 suites in property
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From$72 total
Average 3.0 /5 Recent Reviews Call BookMore Details
Comfort Inn Paducah 5135 Cairo Rd., Paducah, KY 42001
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~27.98 miles east of Cairo
  • Midscale property
  • 3 floors in hotel
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From$70 total
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Fairfield Inn & Suites by Marriott Paducah - Paducah 3950 Coleman Crossing Circle, Paducah, KY 42001
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~28.01 miles east of Cairo
  • Affordable Rural hotel
  • Gym / Fitness Center Available
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From$90 total
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Red Roof Inn Paducah 5106 Old Cairo Rd., Paducah, KY 42001
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~28.01 miles east of Cairo
  • Economy property
  • Check-in time: 14:00
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From$54 total
Average 3.5 /5 Reviews Call BookMore Details
American Inn : 5125 Cairo Rd. 5125 Cairo Rd., Paducah, KY 42001
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~28.02 miles east of Cairo
  • Low-priced hotel
  • Free complimentary breakfast
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From$44 total
Very Good 4.0 /5 Reviews Call BookMore Details
Hampton Inn & Suites Paducah - Paducah 3901 Coleman Crossing Circle, Paducah, KY 42001
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~28.02 miles east of Cairo
  • Three Star Highway hotel
  • Fitness + Health Center
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From$94 total
Very Good 4.5 /5 Guest Reviews Call BookMore Details
Holiday Inn Express Hotel & Suites Paducah West by IHG in Paducah 3996 Hinkleville Rd., Paducah, KY 42001
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~28.04 miles east of Cairo
  • 3 star Highway hotel
  • 16 suites in hotel
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From$96 total
Average 3.0 /5 Read Reviews Call BookMore Details
Spark by Hilton Paducah 3994 Hinkleville Rd., Paducah, KY 42001
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~28.05 miles east of Cairo
  • Mid-scale Airport hotel
  • Hotel has 76 suites
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From$96 total
Very Good 4.0 /5 Reviews Call BookMore Details
Courtyard by Marriott Paducah 3835 Technology Dr., Paducah, KY 42001
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~28.29 miles east of Cairo
  • Affordable Suburban hotel
  • 3 floors in hotel
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From$106 total
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Days Inn by Wyndham Paducah I-24 Exit 4 3901 Hinkleville Rd., Paducah, KY 42001
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~28.75 miles east of Cairo
  • Economy Highway hotel
  • Hotel has 122 rooms
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From$60 total
Average 3.0 /5 Latest Reviews Call BookMore Details
Candlewood Suites Cape Girardeau by IHG 485 South Mount Auburn Rd., Cape Girardeau, MO 65703
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~28.76 miles northwest of Cairo
  • Low-priced Highway property
  • 85 rooms in property
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From$82 total
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Travelers Inn and Suites : 2550 Lone Oak Rd. 2550 Lone Oak Rd., Paducah, KY 42003
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~28.88 miles east of Cairo
  • Two star hotel
  • Shuttle to airport available
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From$45 total
Very Good 4.0 /5 Reviews Call BookMore Details
Quality Inn & Suites Metropolis I-24 in Metropolis 2118 East 5th St., Metropolis, IL 62960
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~28.88 miles east of Cairo
  • Affordable property
  • 52 rooms in hotel
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From$96 total
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Super 8 by Wyndham Metropolis 2055 East 5th St., Metropolis, IL 62960
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~28.89 miles east of Cairo
  • Low Cost Highway hotel
  • 2 floors in property
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From$72 total
Average 3.0 /5 Hotel Reviews Call BookMore Details
Motel 6 Metropolis Il 2119 East 5th St., Metropolis, IL 62960
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~29.04 miles east of Cairo
  • Low priced hotel
  • Check in: 11:00 AM
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From$72 total
Average 3.0 /5 Review Score Call BookMore Details
Holiday Inn Express Metropolis by IHG : 2179 East 5th St. 2179 East 5th St., Metropolis, IL 62960
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~29.10 miles east of Cairo
  • Three Star Rural property
  • 75 rooms in property
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From$78 total
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Hampton Inn Cape Girardeau I 55 East : 207 South Mount Auburn Rd. 207 South Mount Auburn Rd., Cape Girardeau, MO 63703
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~29.41 miles northwest of Cairo
  • Three Star Highway property
  • Check-in time: 3:00 pm
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From$96 total
Excellent 5.0 /5 Read Reviews Call BookMore Details
Victorian Inn & Suites - Cape Girardeau 3256 William St., Cape Girardeau, MO 63703
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~29.41 miles northwest of Cairo
  • 3 star Golf Course hotel
  • Free complimentary breakfast
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From$94 total
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Auburn Place Hotel & Suites - Cape Girardeau 3265 Williams St., Cape Girardeau, MO 63702
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~29.42 miles northwest of Cairo
  • Three Star Highway property
  • 2 meeting rooms in hotel
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From$69 total
Very Good 4.5 /5 Read Reviews Call BookMore Details
Holiday Inn Express & Suites Cape Girardeau I 55 by Ihg in Cape Girardeau 3253 William St., Cape Girardeau, MO 63701
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~29.49 miles northwest of Cairo
  • 3-star property
  • 2 conference rooms in property
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From$96 total
Very Good 4.5 /5 Guest Reviews Call BookMore Details
Fairfield Inn & Suites Cape Girardeau - Cape Girardeay 433 Cape West Crossing, Cape Girardeay, MO 63703
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~29.58 miles northwest of Cairo
  • 3-star property
  • Gym / Fitness Center Available
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From$96 total
Average 3.0 /5 Review Score Call BookMore Details
Drury Lodge 104 South Vantage Dr., Cape Girardeau, MO 63701
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~29.82 miles northwest of Cairo
  • Midscale Highway property
  • Check in: 3:00pm
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From$96 total
Average 3.0 /5 Read Reviews Call BookMore Details
Quality Inn Cape Girardeau North 2011 North Kingshighway St., Cape Girardeau, MO 63701 Website
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~31.37 miles northwest of Cairo
  • Cheap property
  • Hotel has an eco-friendly policy Learn more
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From$72 total
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Hotel 7 Inn Anna 100 Richview Dr., Anna, IL 62906
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~31.39 miles north of Cairo
  • Inexpensive property
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From$72 total
Very Good 4.0 /5 Guest Reviews Call BookMore Details

Next: See My Cairo Hotels with Pricing

Graph: Upcoming 20 Days of Cairo Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Cairo, IL discounts available. The chart reflects the cheapest Cairo hotel for each day and each star rating category.

FAQs about hotels in Cairo

What are the most favored hotels in Cairo?

Hampton Inn Cape Girardeau I 55 East, Hampton Inn & Suites Paducah and Auburn Place Hotel & Suites are the best rated hotels based on customer reviews in the last 365 days.

What are the most luxurious hotels in Cairo?

Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destinatio, Quality Inn Cairo I-57 and Travel Inn & Suites - Sikeston are the top 3 luxury hotels near Cairo city center.

What hotels are closest to the city center of Cairo?

Quality Inn Cairo I-57, Super 8 by Wyndham Charleston, and The Riverstone Hotel Charleston-Sikeston are the properties closest to Cairo city center.

What are the best independent hotels in Cairo?

Auburn Place Hotel & Suites, Travel Inn & Suites - Sikeston and American Inn are the best rated independent hotels (not part of a big brand).

What are the most popular Marriott hotels in Cairo?

Residence Inn by Marriott Paducah, Courtyard by Marriott Cape Girardeau Downtown and Fairfield Inn & Suites by Marriott Paducah are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the best Choice Hotels branded hotels in Cairo?

Comfort Inn & Suites near Six Flags, Comfort Inn Paducah and Quality Inn & Suites Metropolis I-24 are the best rated Choice Hotels branded hotels (based on HotelPlanner reviews score).

What are the best IHG hotels in Cairo?

Holiday Inn Express & Suites Cape Girardeau I 55 by Ihg, Candlewood Suites Paducah by IHG and Candlewood Suites Cape Girardeau by IHG are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

Verified reviews of the city: Cairo, IL

Below are reviews of the city of Cairo, IL from an actual visitor's perspective.

"Spending time with my family"
Score 5.0 / 5

Vincent R., from 26-Jan-2026
The average traveler rating of the city of Cairo, IL shown above is 5.0 out of 5 based on 1 reviews
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