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Cairo Illinois Accommodations

Find hotels & motels in Cairo using the list below. Search for cheap and discounted hotel and motel rates in or close to Cairo, IL for your upcoming individual or group travel. Discover the best Cairo Illinois hotel/motel rooms. Review the Cairo hotel list below to find the perfect lodging. We also have a map of the Cairo hotels.

Cairo Hotels/Accommodations

Quality Inn Cairo I-57 in Cairo 13201 Kessler Rd., Cairo, IL 62914
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  • Three Star Highway hotel
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From$60
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Super 8 by Wyndham Charleston/Sikeston East MO 310 South Story, Charleston, MO 63834
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~10.13 miles southwest of Cairo
  • Low priced Highway hotel
  • Check in: 3:00pm
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From$42
Average 3.5 /5 Read Reviews Call BookMore Details
The Riverstone Hotel Charleston-Sikeston 102 Drake St., Charleston, MO 63834
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~11.88 miles southwest of Cairo
  • Low Cost Highway property
  • Check in: 3:00PM
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From$59
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Americas Best Value Inn Ullin Mounds 128 Cheekwood Lane, Ullin, IL 62992
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~17.88 miles north of Cairo
  • Economy property
  • Check in: 15:00
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From$60
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Motel 6 Sikeston Mo : 110 South Interstate Dr. 110 South Interstate Dr., SIKESTON, MO 63801
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~20.96 miles west of Cairo
  • Economical hotel
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From$60
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Best Western Plus Sikeston : 120 South Interstate Dr. 120 South Interstate Dr., Sikeston, MO 63801
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~21.00 miles west of Cairo
  • 2 star Highway property
  • 2 floors in hotel
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From$42
Very Good 4.0 /5 Read Reviews Call BookMore Details
Days Inn and Suites by Wyndham Sikeston - Sikeston 220 South Interstate Dr., Sikeston, MO 63801
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~21.07 miles west of Cairo
  • Cheap property
  • Fitness center on property
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From$60
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Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) in Sikeston 100 Matthews Lane, Sikeston, MO 63801
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~21.31 miles west of Cairo
  • Three Star Highway property
  • Check-in time: 3:00 PM
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From$80
Very Good 4.0 /5 Reviews Call BookMore Details
Super 8 by Wyndham Sikeston/Miner Area - Sikeston 2609 East Malone, Sikeston, MO 63801
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~21.32 miles west of Cairo
  • 2-star Convention Center hotel
  • Free comp. breakfast
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From$60
Average 3.0 /5 Review Score Call BookMore Details
Comfort Inn : 109 Matthews Lane 109 Matthews Lane, Sikeston, MO 63801
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~21.34 miles west of Cairo
  • 3 star Highway property
  • Check in: 11:00
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From$85
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Hampton Inn Sikeston 1240 Commerce Dr., Sikeston, MO 63801
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~24.48 miles west of Cairo
  • Mid-scale Rural property
  • Free comp. breakfast
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From$80
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Holiday Inn Express & Suites Sikeston An Ihg Hotel : 115 Hospitality Dr. 115 Hospitality Dr., Sikeston, MO 63801
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~24.49 miles west of Cairo
  • Mid-scale Rural hotel
  • 73 rooms in hotel
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From$80
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Residence Inn by Marriott Paducah 3900 Coleman Crossing Circle, Paducah, KY 42001
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~25.66 miles east of Cairo
  • Midscale Suburban property
  • Gym is available on property
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From$89
Very Good 4.0 /5 Recent Reviews Call BookMore Details
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Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destinatio - Metropolis 100 East Front St., Metropolis, IL 62960
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~26.28 miles east of Cairo
  • High-end hotel
  • 7 floors in hotel
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From$160
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Baymont by Wyndham Metropolis 203 East Front St., Metropolis, IL 62960
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~26.32 miles east of Cairo
  • Low priced Riverfront hotel
  • Check in time: 3:00PM
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From$45
Average 3.0 /5 Recent Reviews Call BookMore Details
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Econo Lodge in Metropolis 1415 East 5th St., Metropolis, IL 62960
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~27.38 miles east of Cairo
  • 2-star hotel
  • Check in: 11:00
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From$60
Not Good 1.0 /5 Review Score Call BookMore Details
 Econo Lodge Paducah West I-24 - Paducah 5120 Hinkleville Rd., Paducah, KY 42001
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~27.55 miles east of Cairo
  • Cheap Airport property
  • Check-in time: 15:00pm
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From$60
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Baymont by Wyndham Paducah - Paducah 5300 Old Cairo Rd., Paducah, KY 42001
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~27.64 miles east of Cairo
  • Midscale hotel
  • Hotel has 74 rooms
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From$40
Poor 2.0 /5 Review Score Call BookMore Details
Courtyard by Marriott Cape Girardeau Downtown 400 Broadway St., Cape Girardeau, MO 63701
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~27.65 miles northwest of Cairo
  • 3 star Downtown hotel
  • Hotel has 5 floors
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From$80
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Drury Suites Paducah 2930 James Sanders Blvd., Paducah, KY 42001
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~27.70 miles east of Cairo
  • Affordable Suburban hotel
  • 120 suites in hotel
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From$99
Very Good 4.0 /5 Review Score Call BookMore Details
Quality Suites Paducah I-24 - Paducah 2880 James Sanders Blvd., Paducah, KY 42001 Website
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~27.73 miles east of Cairo
  • Cheap Highway property
  • Complimentary breakfast is offered
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From$60
Average 3.0 /5 Latest Reviews Call BookMore Details
Comfort Inn & Suites near Six Flags 960 West Pointe Court, Lithia Springs, GA 30122 Website
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~27.80 miles east of Cairo
  • 3-star Downtown property
  • 2 floors in hotel
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From$70
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Garner Hotel Paducah West by IHG : 145 Mcbride Lane 145 Mcbride Lane, Paducah, KY 42001
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~27.80 miles east of Cairo
  • Three Star Highway property
  • 17 suites in property
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From$49
Very Good 4.0 /5 Read Reviews Call BookMore Details
Hotel 7 Inn Paducah - Paducah 5001 Hinkleville Rd., Paducah, KY 42001
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~27.81 miles east of Cairo
  • 2 star hotel
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From$60
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La Quinta Inn & Suites by Wyndham Paducah : 3960 Coleman Crossing Cir 3960 Coleman Crossing Cir, Paducah, KY 42001
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~27.90 miles east of Cairo
  • Mid-scale Highway hotel
  • 4 floors in property
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From$80
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Candlewood Suites Paducah by IHG 3940 Coleman Crossing Circle, Paducah, KY 42001
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~27.91 miles east of Cairo
  • 3 star Rural hotel
  • Fitness / Gym is on-site
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From$60
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Homewood Suites by Hilton Paducah 3925 Coleman Crossing Cir, Paducah, KY 42001
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~27.94 miles east of Cairo
  • 3 star Highway property
  • Free breakfast available
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From$109
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Comfort Suites 3918 Coleman Crossing Cir Paducah Ky 42001, Paducah, KY 42001
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~27.96 miles east of Cairo
  • 2-star Rural hotel
  • 72 suites in hotel
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From$60
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Comfort Inn Paducah - Paducah 5135 Cairo Rd., Paducah, KY 42001
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~27.98 miles east of Cairo
  • Mid-scale property
  • 2 meeting rooms in property
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From$59
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Fairfield Inn & Suites by Marriott Paducah 3950 Coleman Crossing Circle, Paducah, KY 42001
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~28.01 miles east of Cairo
  • Midscale Rural property
  • Hotel has 32 suites
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From$75
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Red Roof Inn Paducah : 5106 Old Cairo Rd. 5106 Old Cairo Rd., Paducah, KY 42001
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~28.01 miles east of Cairo
  • Low priced property
  • 3 floors in property
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From$45
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American Inn - Paducah 5125 Cairo Rd., Paducah, KY 42001
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~28.02 miles east of Cairo
  • Low Cost property
  • Free comp. breakfast
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From$37
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Hampton Inn & Suites Paducah - Paducah 3901 Coleman Crossing Circle, Paducah, KY 42001
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~28.02 miles east of Cairo
  • Affordable Highway hotel
  • Check in time: 3:00 pm
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From$79
Very Good 4.5 /5 Recent Reviews Call BookMore Details
Holiday Inn Express Hotel & Suites Paducah West by IHG 3996 Hinkleville Rd., Paducah, KY 42001
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~28.04 miles east of Cairo
  • Mid-scale Highway hotel
  • 16 suites in property
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From$80
Average 3.0 /5 Hotel Reviews Call BookMore Details
Auburn Place Hotel & Suites - Paducah 3994 Hinkleville Rd., Paducah, KY 42001
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~28.05 miles east of Cairo
  • Midscale Airport property
  • Access to gym on-site
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From$80
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Courtyard by Marriott Paducah 3835 Technology Dr., Paducah, KY 42001
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~28.29 miles east of Cairo
  • Three Star Suburban hotel
  • 3 floors in hotel
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From$89
Very Good 4.0 /5 Review Score Call BookMore Details
Days Inn by Wyndham Paducah I-24 Exit 4 : 3901 Hinkleville Rd. 3901 Hinkleville Rd., Paducah, KY 42001
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~28.75 miles east of Cairo
  • Two star Highway property
  • Check in time: 11:00 am
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From$50
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Candlewood Suites Cape Girardeau by IHG 485 South Mount Auburn Rd., Cape Girardeau, MO 65703
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~28.76 miles northwest of Cairo
  • Cheap Highway property
  • 4 floors in hotel
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From$69
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Travelers Inn and Suites 2550 Lone Oak Rd., Paducah, KY 42003
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~28.88 miles east of Cairo
  • 2-star property
  • 30 suites in property
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From$38
Very Good 4.0 /5 Review Score Call BookMore Details
Quality Inn & Suites Metropolis I-24 2118 East 5th St., Metropolis, IL 62960
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~28.88 miles east of Cairo
  • Mid-scale hotel
  • Check-in: 11:00
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From$80
Very Good 4.0 /5 Read Reviews Call BookMore Details
Super 8 by Wyndham Metropolis 2055 East 5th St., Metropolis, IL 62960
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~28.89 miles east of Cairo
  • Two star Highway hotel
  • Hotel has 63 rooms
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From$60
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Motel 6 Metropolis Il 2119 East 5th St., Metropolis, IL 62960
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~29.04 miles east of Cairo
  • Cheap hotel
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From$60
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Holiday Inn Express Metropolis by IHG 2179 East 5th St., Metropolis, IL 62960
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~29.10 miles east of Cairo
  • 3 star Rural property
  • Fitness / Gym is on-site
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From$65
Very Good 4.0 /5 Reviews Call BookMore Details
Hampton Inn Cape Girardeau I 55 East - Cape Girardeau 207 South Mount Auburn Rd., Cape Girardeau, MO 63703
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~29.41 miles northwest of Cairo
  • Midscale Highway hotel
  • 4 floors in property
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From$80
Excellent 5.0 /5 Guest Reviews Call BookMore Details
Victorian Inn & Suites - Cape Girardeau 3256 William St., Cape Girardeau, MO 63703
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~29.41 miles northwest of Cairo
  • Three Star Golf Course hotel
  • Check in: 3:00 pm
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From$79
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Auburn Place Hotel & Suites : 3265 Williams St. 3265 Williams St., Cape Girardeau, MO 63702
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~29.42 miles northwest of Cairo
  • 3-star Highway property
  • Free complimentary breakfast
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From$58
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Holiday Inn Express & Suites Cape Girardeau I 55 by Ihg : 3253 William St. 3253 William St., Cape Girardeau, MO 63701
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~29.49 miles northwest of Cairo
  • Mid-scale property
  • Hotel has 2 meeting rooms
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From$80
Very Good 4.5 /5 Reviews Call BookMore Details
Fairfield Inn & Suites Cape Girardeau in Cape Girardeay 433 Cape West Crossing, Cape Girardeay, MO 63703
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~29.58 miles northwest of Cairo
  • Midscale property
  • Comp. Breakfast
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From$80
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Drury Suites Cape Girardeau 3303 Campster Dr., Cape Girardeau, MO 63701
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~29.72 miles northwest of Cairo
  • Affordable Highway hotel
  • Has environment-friendly policy Learn more
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From$85
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Drury Lodge 104 South Vantage Dr., Cape Girardeau, MO 63701
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~29.82 miles northwest of Cairo
  • Three Star Highway hotel
  • Gym is available on property
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From$80
Average 3.0 /5 Recent Reviews Call BookMore Details

Next: See My Cairo Hotels with Pricing

Graph: Upcoming 20 Days of Cairo Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Cairo, IL discounts available. The chart reflects the cheapest Cairo hotel for each day and each star rating category.

FAQs about hotels in Cairo

What are the most favored hotels in Cairo?

Hampton Inn Cape Girardeau I 55 East, Hampton Inn & Suites Paducah and Auburn Place Hotel & Suites are the best rated hotels based on customer reviews in the last 365 days.

What are the most luxurious hotels in Cairo?

Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destinatio, Quality Inn Cairo I-57 and Travel Inn & Suites - Sikeston are the top 3 luxury hotels near Cairo city center.

What hotels are closest to the city center of Cairo?

Quality Inn Cairo I-57, Super 8 by Wyndham Charleston, and The Riverstone Hotel Charleston-Sikeston are the properties closest to Cairo city center.

What are the best independent hotels in Cairo?

Auburn Place Hotel & Suites, Drury Suites Cape Girardeau and Travel Inn & Suites - Sikeston are the best rated independent hotels (not part of a big brand).

What are the most popular Marriott hotels in Cairo?

Residence Inn by Marriott Paducah, Courtyard by Marriott Cape Girardeau Downtown and Fairfield Inn & Suites by Marriott Paducah are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the best Choice Hotels branded hotels in Cairo?

Comfort Inn & Suites near Six Flags, Comfort Inn Paducah and Quality Inn & Suites Metropolis I-24 are the best rated Choice Hotels branded hotels (based on HotelPlanner reviews score).

What are the best IHG hotels in Cairo?

Holiday Inn Express & Suites Cape Girardeau I 55 by Ihg, Candlewood Suites Paducah by IHG and Candlewood Suites Cape Girardeau by IHG are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

Verified reviews of the city: Cairo, IL

Below are reviews of the city of Cairo, IL from an actual visitor's perspective.

"Spending time with my family"
Score 5.0 / 5

Vincent R., from 26-Jan-2026
The average traveler rating of the city of Cairo, IL shown above is 5.0 out of 5 based on 1 reviews
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