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Cairo Illinois Accommodations

Find hotels & motels in Cairo using the list below. Search for cheap and discounted hotel and motel rates in or close to Cairo, IL for your upcoming individual or group travel. Discover the best Cairo Illinois hotel/motel rooms. Review the Cairo hotel list below to find the perfect lodging. We also have a map of the Cairo hotels.

Cairo Hotels, Motels & Accommodations

Quality Inn Cairo I-57 - Cairo 13201 Kessler Rd., Cairo, IL 62914
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  • 3 star Highway hotel
  • 38 sleeping rooms in hotel
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From$60
Poor 2.0 /5 Recent Reviews Call BookMore Details
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Super 8 by Wyndham Charleston/Sikeston East MO - Charleston 310 South Story, Charleston, MO 63834
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~10.13 miles southwest of Cairo
  • Low priced Highway property
  • 7 suites in hotel
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From$42
Average 3.5 /5 Guest Reviews Call BookMore Details
The Riverstone Hotel 102 Drake St., Charleston, MO 63834
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~11.88 miles southwest of Cairo
  • Economy Highway hotel
  • 9 suites in property
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From$59
Average 3.0 /5 Latest Reviews Call BookMore Details
Americas Best Value Inn Ullin Mounds - Ullin 128 Cheekwood Lane, Ullin, IL 62992
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~17.88 miles north of Cairo
  • Inexpensive hotel
  • Hotel has 40 rooms
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From$60
Average 3.0 /5 Review Score Call BookMore Details
Motel 6 Sikeston Mo in SIKESTON 110 South Interstate Dr., SIKESTON, MO 63801
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~20.96 miles west of Cairo
  • Cheap hotel
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From$60
Average 3.0 /5 Latest Reviews Call BookMore Details
Best Western Plus Sikeston I-55 120 South Interstate Dr., Sikeston, MO 63801
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~21.00 miles west of Cairo
  • Low Cost Highway hotel
  • Hotel has a green policy Read more
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From$42
Very Good 4.0 /5 Review Score Call BookMore Details
Days Inn and Suites by Wyndham Sikeston : 220 South Interstate Dr. 220 South Interstate Dr., Sikeston, MO 63801
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~21.07 miles west of Cairo
  • Cheap hotel
  • Check-in: 03:00 PM
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From$60
Average 3.0 /5 Recent Reviews Call BookMore Details
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) in Sikeston 100 Matthews Lane, Sikeston, MO 63801
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~21.31 miles west of Cairo
  • Three Star Highway property
  • Free breakfast
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From$80
Very Good 4.0 /5 Read Reviews Call BookMore Details
Super 8 by Wyndham Sikeston/Miner Area 2609 East Malone, Sikeston, MO 63801
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~21.32 miles west of Cairo
  • 2 star Convention Center property
  • Check-in: 01:00
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From$60
Average 3.0 /5 Read Reviews Call BookMore Details
Comfort Inn - Sikeston 109 Matthews Lane, Sikeston, MO 63801
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~21.34 miles west of Cairo
  • Three Star Highway property
  • Gym is available on property
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From$85
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Hampton Inn Sikeston : 1240 Commerce Dr. 1240 Commerce Dr., Sikeston, MO 63801
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~24.48 miles west of Cairo
  • Midscale Rural hotel
  • Gym / Fitness Center Available
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From$80
Average 3.0 /5 Reviews Call BookMore Details
Holiday Inn Express & Suites Sikeston An Ihg Hotel - Sikeston 115 Hospitality Dr., Sikeston, MO 63801
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~24.49 miles west of Cairo
  • 3-star Rural property
  • 73 sleeping rooms in hotel
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From$80
Average 3.0 /5 Reviews Call BookMore Details
Residence Inn by Marriott Paducah : 3900 Coleman Crossing Circle 3900 Coleman Crossing Circle, Paducah, KY 42001
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~25.66 miles east of Cairo
  • Mid-scale Suburban property
  • Hotel has 74 rooms
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From$89
Very Good 4.0 /5 Read Reviews Call BookMore Details
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Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destinatio - Metropolis 100 East Front St., Metropolis, IL 62960
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~26.28 miles east of Cairo
  • 4-star property
  • 12 suites in hotel
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From$160
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Baymont by Wyndham Metropolis in Metropolis 203 East Front St., Metropolis, IL 62960
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~26.32 miles east of Cairo
  • Two-star Riverfront property
  • 8 suites in property
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From$45
Average 3.0 /5 Recent Reviews Call BookMore Details
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Econo Lodge 1415 East 5th St., Metropolis, IL 62960
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~27.38 miles east of Cairo
  • Two-star property
  • Hotel has 45 rooms
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From$60
Not Good 1.0 /5 Reviews Call BookMore Details
 Econo Lodge Paducah West I-24 : 5120 Hinkleville Rd. 5120 Hinkleville Rd., Paducah, KY 42001
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~27.55 miles east of Cairo
  • Low-priced Airport property
  • 75 rooms in hotel
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From$60
Average 3.0 /5 Hotel Reviews Call BookMore Details
Baymont by Wyndham Paducah 5300 Old Cairo Rd., Paducah, KY 42001
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~27.64 miles east of Cairo
  • Affordable property
  • Check-in time: 15:00
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From$40
Poor 2.0 /5 Read Reviews Call BookMore Details
Courtyard by Marriott Cape Girardeau Downtown 400 Broadway St., Cape Girardeau, MO 63701
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~27.65 miles northwest of Cairo
  • Affordable Downtown hotel
  • 13 suites in hotel
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From$80
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Drury Suites Paducah 2930 James Sanders Blvd., Paducah, KY 42001
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~27.70 miles east of Cairo
  • Mid-scale Suburban property
  • Gym is available on property
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From$99
Very Good 4.0 /5 Reviews Call BookMore Details
Quality Suites Paducah I-24 2880 James Sanders Blvd., Paducah, KY 42001 Website
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~27.73 miles east of Cairo
  • Low Cost Highway hotel
  • Fitness center on property
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From$60
Average 3.0 /5 Hotel Reviews Call BookMore Details
Comfort Inn & Suites near Six Flags 960 West Pointe Court, Lithia Springs, GA 30122 Website
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~27.80 miles east of Cairo
  • Affordable Downtown property
  • 5 suites in property
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From$70
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Garner Hotel Paducah West by IHG - Paducah 145 Mcbride Lane, Paducah, KY 42001
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~27.80 miles east of Cairo
  • 3-star Highway hotel
  • Hotel has 17 suites
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From$49
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Hotel 7 Inn Paducah - Paducah 5001 Hinkleville Rd., Paducah, KY 42001
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~27.81 miles east of Cairo
  • Low priced hotel
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From$60
Average 3.0 /5 Read Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham Paducah 3960 Coleman Crossing Cir, Paducah, KY 42001
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~27.90 miles east of Cairo
  • Three Star Highway hotel
  • Check in: 3;00PM
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From$80
Average 3.0 /5 Guest Reviews Call BookMore Details
Candlewood Suites Paducah by IHG in Paducah 3940 Coleman Crossing Circle, Paducah, KY 42001
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~27.91 miles east of Cairo
  • 3-star Rural property
  • Gym is available on property
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From$60
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Homewood Suites by Hilton Paducah 3925 Coleman Crossing Cir, Paducah, KY 42001
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~27.94 miles east of Cairo
  • 3 star Highway property
  • Hotel has 97 rooms
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From$109
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Comfort Suites 3918 Coleman Crossing Cir Paducah Ky 42001, Paducah, KY 42001
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~27.96 miles east of Cairo
  • Cheap Rural hotel
  • Fitness + Health Center
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From$60
Average 3.0 /5 Recent Reviews Call BookMore Details
Comfort Inn Paducah 5135 Cairo Rd., Paducah, KY 42001
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~27.98 miles east of Cairo
  • Three Star hotel
  • 64 suites in hotel
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From$59
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Fairfield Inn & Suites by Marriott Paducah 3950 Coleman Crossing Circle, Paducah, KY 42001
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~28.01 miles east of Cairo
  • 3-star Rural property
  • 32 suites in property
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From$75
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Red Roof Inn Paducah - Paducah 5106 Old Cairo Rd., Paducah, KY 42001
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~28.01 miles east of Cairo
  • Two-star hotel
  • 8 suites in hotel
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From$45
Average 3.5 /5 Latest Reviews Call BookMore Details
American Inn in Paducah 5125 Cairo Rd., Paducah, KY 42001
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~28.02 miles east of Cairo
  • Inexpensive property
  • Check in: 14:00
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From$37
Very Good 4.0 /5 Read Reviews Call BookMore Details
Hampton Inn & Suites Paducah - Paducah 3901 Coleman Crossing Circle, Paducah, KY 42001
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~28.02 miles east of Cairo
  • Affordable Highway hotel
  • Free comp. breakfast
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From$79
Very Good 4.5 /5 Review Score Call BookMore Details
Holiday Inn Express Hotel & Suites Paducah West by IHG in Paducah 3996 Hinkleville Rd., Paducah, KY 42001
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~28.04 miles east of Cairo
  • 3-star Highway property
  • 85 sleeping rooms in hotel
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From$80
Average 3.0 /5 Hotel Reviews Call BookMore Details
Auburn Place Hotel & Suites - Paducah : 3994 Hinkleville Rd. 3994 Hinkleville Rd., Paducah, KY 42001
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~28.05 miles east of Cairo
  • Mid-scale Airport property
  • 76 suites in property
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From$80
Very Good 4.0 /5 Reviews Call BookMore Details
Courtyard by Marriott Paducah : 3835 Technology Dr. 3835 Technology Dr., Paducah, KY 42001
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~28.29 miles east of Cairo
  • 3-star Suburban property
  • Fitness / Gym is on-site
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From$89
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Days Inn by Wyndham Paducah I-24 Exit 4 in Paducah 3901 Hinkleville Rd., Paducah, KY 42001
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~28.75 miles east of Cairo
  • Economy Highway property
  • Hotel has 32 suites
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From$50
Average 3.0 /5 Latest Reviews Call BookMore Details
Candlewood Suites Cape Girardeau by IHG : 485 South Mount Auburn Rd. 485 South Mount Auburn Rd., Cape Girardeau, MO 65703
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~28.76 miles northwest of Cairo
  • Inexpensive Highway hotel
  • Fitness + Health Center
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From$69
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Travelers Inn and Suites in Paducah 2550 Lone Oak Rd., Paducah, KY 42003
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~28.88 miles east of Cairo
  • Economical property
  • Check in time: 2:00PM
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From$38
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Quality Inn & Suites Metropolis I-24 in Metropolis 2118 East 5th St., Metropolis, IL 62960
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~28.88 miles east of Cairo
  • Midscale property
  • 52 rooms in property
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From$80
Very Good 4.0 /5 Read Reviews Call BookMore Details
Super 8 by Wyndham Metropolis : 2055 East 5th St. 2055 East 5th St., Metropolis, IL 62960
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~28.89 miles east of Cairo
  • Cheap Highway property
  • Free comp. breakfast
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From$60
Average 3.0 /5 Review Score Call BookMore Details
Motel 6 Metropolis Il : 2119 East 5th St. 2119 East 5th St., Metropolis, IL 62960
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~29.04 miles east of Cairo
  • Two star hotel
  • Check in: 11:00 AM
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From$60
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Holiday Inn Express Metropolis by IHG : 2179 East 5th St. 2179 East 5th St., Metropolis, IL 62960
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~29.10 miles east of Cairo
  • Mid-scale Rural property
  • Comp. Breakfast
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From$65
Very Good 4.0 /5 Read Reviews Call BookMore Details
Hampton Inn Cape Girardeau I 55 East 207 South Mount Auburn Rd., Cape Girardeau, MO 63703
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~29.41 miles northwest of Cairo
  • Midscale Highway property
  • Hotel has 4 floors
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From$80
Excellent 5.0 /5 Read Reviews Call BookMore Details
Victorian Inn & Suites - Cape Girardeau 3256 William St., Cape Girardeau, MO 63703
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~29.41 miles northwest of Cairo
  • 3-star Golf Course property
  • 133 sleeping rooms in hotel
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From$79
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Auburn Place Hotel & Suites - Cape Girardeau 3265 Williams St., Cape Girardeau, MO 63702
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~29.42 miles northwest of Cairo
  • Mid-scale Highway property
  • Hotel has 5 suites
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From$58
Very Good 4.5 /5 Hotel Reviews Call BookMore Details
Holiday Inn Express & Suites Cape Girardeau I 55 by Ihg in Cape Girardeau 3253 William St., Cape Girardeau, MO 63701
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~29.49 miles northwest of Cairo
  • 3 star hotel
  • 2 meeting rooms in hotel
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From$80
Very Good 4.5 /5 Read Reviews Call BookMore Details
Fairfield Inn & Suites Cape Girardeau 433 Cape West Crossing, Cape Girardeay, MO 63703
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~29.58 miles northwest of Cairo
  • Three Star property
  • Check in: 3:00PM
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From$80
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Drury Suites Cape Girardeau 3303 Campster Dr., Cape Girardeau, MO 63701
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~29.72 miles northwest of Cairo
  • Midscale Highway property
  • Fitness / Gym is on-site
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From$85
Very Good 4.5 /5 Guest Reviews Call BookMore Details
Drury Lodge - Cape Girardeau 104 South Vantage Dr., Cape Girardeau, MO 63701
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~29.82 miles northwest of Cairo
  • Mid-scale Highway property
  • Gym / Fitness Center Available
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From$80
Average 3.0 /5 Recent Reviews Call BookMore Details

Next: See My Cairo Hotels with Pricing

Graph: Upcoming 20 Days of Cairo Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Cairo, IL discounts available. The chart reflects the cheapest Cairo hotel for each day and each star rating category.

FAQs about hotels in Cairo

What are the most favored hotels in Cairo?

Hampton Inn Cape Girardeau I 55 East, Hampton Inn & Suites Paducah and Auburn Place Hotel & Suites are the best rated hotels based on customer reviews in the last 365 days.

What are the most luxurious hotels in Cairo?

Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destinatio, Quality Inn Cairo I-57 and Travel Inn & Suites - Sikeston are the top 3 luxury hotels near Cairo city center.

What hotels are closest to the city center of Cairo?

Quality Inn Cairo I-57, Super 8 by Wyndham Charleston, and The Riverstone Hotel are the properties closest to Cairo city center.

What are the best independent hotels in Cairo?

Auburn Place Hotel & Suites, Drury Suites Cape Girardeau and Travel Inn & Suites - Sikeston are the best rated independent hotels (not part of a big brand).

What are the most popular Marriott hotels in Cairo?

Residence Inn by Marriott Paducah, Courtyard by Marriott Cape Girardeau Downtown and Fairfield Inn & Suites by Marriott Paducah are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the best Choice Hotels branded hotels in Cairo?

Comfort Inn & Suites near Six Flags, Comfort Inn Paducah and Quality Inn & Suites Metropolis I-24 are the best rated Choice Hotels branded hotels (based on HotelPlanner reviews score).

What are the best IHG hotels in Cairo?

Holiday Inn Express & Suites Cape Girardeau I 55 by Ihg, Candlewood Suites Paducah by IHG and Candlewood Suites Cape Girardeau by IHG are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

Verified reviews of the city: Cairo, IL

Below are reviews of the city of Cairo, IL from an actual visitor's perspective.

"Spending time with my family"
Score 5.0 / 5

Vincent R., from 26-Jan-2026
The average traveler rating of the city of Cairo, IL shown above is 5.0 out of 5 based on 1 reviews
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