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Cairo Illinois Accommodations

Find hotels & motels in Cairo using the list below. Search for cheap and discounted hotel and motel rates in or close to Cairo, IL for your upcoming individual or group travel. Discover the best Cairo Illinois hotel/motel rooms. Review the Cairo hotel list below to find the perfect lodging. We also have a map of the Cairo hotels.

Cairo Hotels & Accommodations

Courtyard by Marriott Cape Girardeau Downtown 400 Broadway St., Cape Girardeau, MO 63701 ~27.69 miles northwest of Cairo
  • Midscale hotel
  • 91 rooms in property
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Excellent 9.6 /10 Recent Reviews Call BookMore Details
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Fairfield Inn & Suites by Marriott Cape Girardeau 433 CAPE WEST CROSSINGS, Cape Girardeau, MO 63703 ~28.90 miles northwest of Cairo
  • Midscale hotel
  • Hotel has 22 suites
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Excellent 9.1 /10 Guest Reviews Call BookMore Details
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG 3253 William Street, Cape Girardeau, MO 63701 ~29.55 miles northwest of Cairo
  • Three Star hotel
  • 102 suites in hotel
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Excellent 9.4 /10 Hotel Reviews Call BookMore Details
Hampton Inn Cape Girardeau I 55 East 207 South Mt. Auburn Rd, Cape Girardeau, MO 63703 ~29.40 miles northwest of Cairo
  • 3 star property
  • 4 floors in hotel
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Excellent 9.6 /10 Hotel Reviews Call BookMore Details
Courtyard by Marriott Paducah 3835 Technology Dr, Paducah, KY 42001 ~28.43 miles east of Cairo
  • Mid-scale hotel
  • 3 floors in hotel
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Very Good 8.6 /10 Recent Reviews Call BookMore Details
Hampton Inn Sikeston 1240 Commerce Drive, Sikeston, MO 63801 ~24.94 miles west of Cairo
  • Affordable property
  • Hotel has 8 suites
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Excellent 9.0 /10 Hotel Reviews Call BookMore Details
Homewood Suites by Hilton Paducah 3925 Coleman Crossing Cir, Paducah, KY 42001 ~28.06 miles east of Cairo
  • Affordable hotel
  • Hotel has 97 rooms
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Excellent 9.4 /10 Recent Reviews Call BookMore Details
Holiday Inn Express Hotel & Suites Paducah West by IHG 3996 Hinkleville Road, Paducah, KY 42001 ~28.13 miles east of Cairo
  • Affordable hotel
  • Free breakfast available
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Excellent 9.6 /10 Latest Reviews Call BookMore Details
Harrahs Metropolis Hotel & Casino - a Caesars Rewards Destination 100 East Front St, Metropolis, IL 62960 ~26.36 miles east of Cairo
  • Midscale hotel
  • Pets are Allowed
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Very Good 8.2 /10 Guest Reviews Call BookMore Details
Holiday Inn Express & Suites Sikeston Southwest by IHG 115 Hospitality Dr, Sikeston, MO 63801 ~24.55 miles west of Cairo
  • Affordable hotel
  • Check in time: 3:00 PM - anytime
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Very Good 8.8 /10 Hotel Reviews Call BookMore Details
Holiday Inn Paducah Riverfront by IHG 600 North 4th Street, Paducah, KY 42001 ~32.52 miles east of Cairo
  • Midscale property
  • 5 floors in property
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Excellent 9.0 /10 Hotel Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham Jackson / Cape Girardeau 3003 SOUTH OLD ORCHARD ROAD, Jackson, MO 63755 ~33.45 miles northwest of Cairo
  • Affordable property
  • 80 sleeping rooms in hotel
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Very Good 8.4 /10 Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham Paducah 3960 Coleman Crossing Cir, Paducah, KY 42001 ~28.04 miles east of Cairo
  • Three Star property
  • Check-in: 3:00 PM - 2:00 AM
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Very Good 8.6 /10 Latest Reviews Call BookMore Details
Candlewood Suites Cape Girardeau by IHG 485 South Mount Auburn Rd, Cape Girardeau, MO 65703 ~28.81 miles northwest of Cairo
  • 3 star property
  • Hotel has a green policy Learn more
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Very Good 8.0 /10 Hotel Reviews Call BookMore Details
Hampton Inn & Suites Paducah 3901 Coleman Crossing Cir, Paducah, KY 42001 ~28.12 miles east of Cairo
  • 3 star property
  • Gym / Fitness Center Available
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Excellent 9.2 /10 Latest Reviews Call BookMore Details
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Fairfield Inn & Suites by Marriott Paducah 3950 Coleman Crossing Circle, Paducah, KY 42001 ~28.03 miles east of Cairo
  • 3-star property
  • Gym is available on property
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Very Good 8.8 /10 Guest Reviews Call BookMore Details
The Riverview 777 Main St, Cape Girardeau, MO 63701 ~27.83 miles northwest of Cairo
  • 4-star hotel
  • Check-in: 3:00 PM - 2:00 AM
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Excellent 9.4 /10 Hotel Reviews Call BookMore Details
Tru by Hilton Cape Girardeau 2520 Veterans Memorial Dr, Cape Girardeau, MO 63701 ~32.72 miles northwest of Cairo
  • Affordable property
  • Fitness center on property
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Excellent 9.3 /10 Hotel Reviews Call BookMore Details
Comfort Suites Jackson-Cape Girardeau 2904 Old Orchard Rd, Jackson, MO 63755 ~33.47 miles northwest of Cairo
  • Mid-scale hotel
  • Check in time: 3:00 PM - anytime
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Very Good 8.0 /10 Guest Reviews Call BookMore Details
Residence Inn by Marriott Paducah 3900 Coleman Crossing Cir, Paducah, KY 42001 ~28.09 miles east of Cairo
  • 3-star property
  • Check-in time: 3:00 PM - anytime
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Very Good 8.6 /10 Hotel Reviews Call BookMore Details
Candlewood Suites Paducah by IHG 3940 Coleman Crossing Cir, Paducah, KY 42001 ~28.01 miles east of Cairo
  • Three Star property
  • Pets/Animals Allowed
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Very Good 8.0 /10 Guest Reviews Call BookMore Details
Holiday Inn Express & Suites Union City by IHG 810 BREAM BOULEVARD, Union City, TN 38261 ~40.30 miles south of Cairo
  • Mid-scale property
  • Check in: 3:00 PM
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Excellent 9.0 /10 Read Reviews Call BookMore Details
Comfort Suites Paducah Mall Area 3918 COLEMAN CROSSING CIR, Paducah, KY 42001 ~28.06 miles east of Cairo
  • 3 star property
  • Gym / Fitness Center Available
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Very Good 8.0 /10 Read Reviews Call BookMore Details
Best Western Plus Sikeston I-55 120 South Interstate Drive, Sikeston, MO 63801 ~21.10 miles west of Cairo
  • Mid-scale property
  • 2 floors in hotel
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Very Good 8.4 /10 Guest Reviews Call BookMore Details
Garner Hotel Paducah West by IHG 145 Mcbride Ln, Paducah, KY 42001 ~27.90 miles east of Cairo
  • 3 star property
  • Pets Welcome
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Average 7.8 /10 Guest Reviews Call BookMore Details
Spark by Hilton Paducah 3994 Hinkleville Rd, Paducah, KY 42001 ~28.11 miles east of Cairo
  • Three Star property
  • Pets are OK
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Very Good 8.9 /10 Latest Reviews Call BookMore Details
MainStay Suites at Discovery Park of America 1111 Blue Heron Lane Building B, Union City, TN 38261 ~40.24 miles south of Cairo
  • 3-star hotel
  • Hotel has 37 rooms
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Very Good 8.8 /10 Review Score Call BookMore Details
Holiday Inn Express Metropolis by IHG 2179 East 5th Street, Metropolis, IL 62960 ~29.29 miles east of Cairo
  • Midscale property
  • Hotel has 3 floors
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Very Good 8.8 /10 Read Reviews Call BookMore Details
Fairfield Inn & Suites by Marriott Sikeston 1239 Commerce Drive, Sikeston, MO 63801 ~25.01 miles west of Cairo
  • Midscale hotel
  • 53 rooms in hotel
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Excellent 9.4 /10 Recent Reviews Call BookMore Details
TownePlace Suites by Marriott Sikeston 1239 Commerce Drive, Sikeston, MO 63801 ~24.98 miles west of Cairo
  • Mid-scale hotel
  • Pet Friendly
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Very Good 8.8 /10 Read Reviews Call BookMore Details
The 1857 210 Kentucky Ave, Paducah, KY 42001 ~32.78 miles east of Cairo
  • 3 star property
  • Check in: 3:00 PM
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Excellent 9.6 /10 Reviews Call BookMore Details
Comfort Inn Paducah I-24 5135 Cairo Rd, Paducah, KY 42001 ~28.07 miles east of Cairo
  • 3-star property
  • Check-in: 3:00 PM - 3:00 AM
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Average 6.8 /10 Latest Reviews Call BookMore Details
The Meadows Hotel 101 Commercial Avenue, Fulton, KY 42041 ~39.02 miles southeast of Cairo
  • Affordable property
  • 14 sleeping rooms in hotel
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Excellent 9.4 /10 Review Score Call BookMore Details
Best Western Paducah Inn 2960 Husband Rd, Paducah, KY 42003 ~32.69 miles east of Cairo
  • Midscale property
  • 47 sleeping rooms in hotel
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Very Good 8.2 /10 Review Score Call BookMore Details
Sleep Inn at Discovery Park of America 1111 BLue Heron Lane, Union City, TN 38261 ~40.24 miles south of Cairo
  • 3-star hotel
  • Hotel has 9 suites
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Excellent 9.2 /10 Hotel Reviews Call BookMore Details
Comfort Inn & Suites Sikeston I-55 109 Matthews Ln, Sikeston, MO 63801 ~21.41 miles west of Cairo
  • 3 star property
  • Check-in time: 2:00 PM - anytime
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Very Good 8.2 /10 Review Score Call BookMore Details
Quality Suites Paducah I-24 2880 James Sanders Blvd, Paducah, KY 42001 ~27.83 miles east of Cairo
  • Midscale property
  • Pets Welcome
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Average 6.7 /10 Latest Reviews Call BookMore Details
Quality Inn Cape Girardeau North 2011 North Kingshighway, Cape Girardeau, MO 63701 ~31.42 miles northwest of Cairo
  • 3-star property
  • Hotel has 2 suites
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Average 7.0 /10 Guest Reviews Call BookMore Details
The Riverstone Hotel Charleston-Sikeston 102 Drake St, Charleston, MO 63834 ~11.80 miles southwest of Cairo
  • Mid-scale hotel
  • Pet Friendly
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Average 6.8 /10 Recent Reviews Call BookMore Details
Super 8 by Wyndham Charleston / Sikeston East MO 310 South Story St, Charleston, MO 63834 ~10.14 miles southwest of Cairo
  • Economy Motel property
  • Hotel has 60 rooms
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Average 6.8 /10 Read Reviews Call BookMore Details
Mustang Inn 5006 Hinkleville Rd, Paducah, KY 42001 ~27.83 miles east of Cairo
  • Midscale hotel
  • Has environment-friendly policy See more
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Very Good 8.4 /10 Reviews Call BookMore Details
Hampton Inn Mayfield Ky 65 Brien Drive, Mayfield, KY 42066 ~34.27 miles east of Cairo
  • 3 star hotel
  • Check in: 3:00 PM - anytime
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Very Good 8.0 /10 Reviews Call BookMore Details
Days Inn and Suites by Wyndham Sikeston 220 South Interstate Dr, Sikeston, MO 63801 ~21.13 miles west of Cairo
  • Cheap hotel
  • Hotel has 2 floors
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Average 7.2 /10 Guest Reviews Call BookMore Details
Super 8 by Wyndham Mayfield 1100 Links Lane, Mayfield, KY 42066 ~34.16 miles southeast of Cairo
  • Inexpensive property
  • Pets are OK
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Average 7.6 /10 Latest Reviews Call BookMore Details
Baymont by Wyndham Metropolis 203 East Front St, Metropolis, IL 62960 ~26.44 miles east of Cairo
  • 3 star Motel hotel
  • Gym / Fitness Center Available
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Average 6.4 /10 Recent Reviews Call BookMore Details
Quality Inn & Suites Metropolis I-24 2118 East 5th St, Metropolis, IL 62960 ~29.04 miles east of Cairo
  • Midscale property
  • 52 rooms in hotel
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Average 7.6 /10 Guest Reviews Call BookMore Details
Eagle Inn Charleston 2811 East Marshall Street, Charleston, MO 63834 ~9.40 miles southwest of Cairo
  • Two-star Motel property
  • Pet-friendly
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Average 6.6 /10 Read Reviews Call BookMore Details
Baymont by Wyndham Paducah 5300 Old Cairo Rd, Paducah, KY 42001 ~27.74 miles east of Cairo
  • Midscale hotel
  • 72 rooms in hotel
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Poor 5.8 /10 Guest Reviews Call BookMore Details
Travel Inn & Suites - Sikeston / Miner (i-55 Exit-67) 100 Matthews Lane, Sikeston, MO 63801 ~21.38 miles west of Cairo
  • Affordable property
  • 2 floors in hotel
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Very Good 8.4 /10 Guest Reviews Call BookMore Details
Days Inn by Wyndham Paducah I-24 Exit 4 3901 Hinkleville Rd, Paducah, KY 42001 ~28.50 miles east of Cairo
  • Low Cost property
  • Pets/Dogs Allowed
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Poor 5.2 /10 Read Reviews Call BookMore Details

Next: See My Cairo Hotels with Pricing

FAQs about hotels in Cairo

What are the top rated hotels in Cairo?

Holiday Inn Express Hotel & Suites Paducah West by IHG, The 1857 and Hampton Inn Cape Girardeau I 55 East are the best rated hotels based on customer reviews in the last 365 days.

What are the 4-5 star hotels in Cairo?

The Riverview, Harrahs Metropolis Hotel & Casino - a Caesars Rewards Destination and The 1857 are the top 3 luxury hotels near Cairo city center.

What hotels are closest to the city center of Cairo?

Eagle Inn Charleston, Super 8 by Wyndham Charleston, and The Riverstone Hotel Charleston-Sikeston are the properties closest to Cairo city center.

What are the best independent hotels in Cairo?

The 1857, The Riverview and The Meadows Hotel are the best rated independent hotels (not part of a big brand).

What are the best Marriott hotels in Cairo?

Courtyard by Marriott Cape Girardeau Downtown, Fairfield Inn & Suites by Marriott Sikeston and Fairfield Inn & Suites by Marriott Cape Girardeau are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the best Choice Hotels branded hotels in Cairo?

Sleep Inn at Discovery Park of America, MainStay Suites at Discovery Park of America and Quality Inn Union City US 51 are the best rated Choice Hotels branded hotels (based on HotelPlanner reviews score).

What are the best Best Western hotels in Cairo?

Best Western Plus Sikeston I-55 and Best Western Paducah Inn are the best rated Best Western branded hotels (based on user reviews score).

What are the most popular IHG hotels in Cairo?

Holiday Inn Express Hotel & Suites Paducah West by IHG, Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG and Holiday Inn Paducah Riverfront by IHG are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

Verified reviews of the city: Cairo, IL

Below are reviews of the city of Cairo, IL from an actual visitor's perspective.

"Spending time with my family"
Score 5.0 / 5

Vincent R., from 26-Jan-2026
The average traveler rating of the city of Cairo, IL shown above is 5.0 out of 5 based on 1 reviews
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