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Desoto Missouri Accommodations

Find hotels in Desoto using the list and search tools below. Search for the cheapest discounted hotel and motel rates in or near Desoto, MO for your corporate or personal leisure travel. We show the best Desoto Missouri hotel rooms. Review the Desoto hotel list below to find the perfect lodging. We also have a map of the Desoto hotels.

Desoto Hotels & Accommodations

Holiday Inn Club Vac Timber Creek : 4800 Us Highway 67 4800 Us Highway 67, Desoto, MO 63020
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  • Affordable property
  • Hotel has 3 floors
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From£67
Very good 4.5 /5 Guest Reviews Call BookMore Details
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Holiday Inn Express Hotel & Suites Festus South St. Louis by Ih 1802 Gamel Cemetery Rd., Festus, MO 63028
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~9.28 miles northeast of Desoto
  • Economy Highway property
  • 85 sleeping rooms in hotel
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From£67
Very good 4.0 /5 Reviews Call BookMore Details
Comfort Inn Festus St. Louis South - Festus 1303 Veterans Blvd., Festus, MO 63028 Website
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~9.48 miles northeast of Desoto
  • Mid-scale Suburban hotel
  • Free breakfast available
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From£33
Very good 4.0 /5 Recent Reviews Call BookMore Details
Baymont by Wyndham Festus : 1200 West Gannon Dr. 1200 West Gannon Dr., Festus, MO 63028
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~9.51 miles northeast of Desoto
  • Affordable Suburban property
  • Free breakfast
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From£54
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La Quinta Inn & Suites by Wyndham Festus - St. Louis South : 1001 Veterans Blvd. 1001 Veterans Blvd., Festus, MO 63028
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~9.70 miles northeast of Desoto
  • 3-star Suburban property
  • Free comp. breakfast
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From£60
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Super 8 by Wyndham Pevely 1711 Highway Z, Pevely, MO 63070
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~13.03 miles northeast of Desoto
  • Two-star hotel
  • Check in: 11:00 AM
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From£26
Very good 4.0 /5 Reviews Call BookMore Details
Super 8 by Wyndham Bonne Terre : 8 Northwood Dr. 8 Northwood Dr., Bonne Terre, MO 63628
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~14.93 miles south of Desoto
  • Two-star property
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From£45
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Motel 6 Bonne Terre Mo : 1017 Highway K 1017 Highway K, Bonne Terre, MO 63628
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~15.12 miles south of Desoto
  • Low-priced property
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From£45
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Super 8 by Wyndham Potosi 820 East High St., Potosi, MO 63664
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~18.89 miles southwest of Desoto
  • Two star Highway property
  • 48 sleeping rooms in hotel
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From£37
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Quality Inn & Suites - Arnold 3610 West Outer Rd., Arnold, MO 63010 Website
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~20.97 miles northeast of Desoto
  • 2 star Suburban property
  • 19 suites in property
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From£45
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Woodspring Suites St. Louis Arnold - Arnold 888 Arnold Commons Dr., Arnold, MO 63010
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~22.46 miles northeast of Desoto
  • Cheap Highway hotel
  • 124 sleeping rooms in hotel
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From£24
Very good 4.0 /5 Latest Reviews Call BookMore Details
Crown Pointe Lodge, BW Signature Collection : 4245 Hunt Rd. 4245 Hunt Rd., Farmington, MO 63640
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~23.27 miles south of Desoto
  • Mid-scale Golf Course property
  • Hotel has a green policy Learn more
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From£46
Very good 4.0 /5 Recent Reviews Call BookMore Details
Best Western St. Louis Inn - Saint Louis 6224 Heimos Industrial Park Dr., Saint Louis, MO 63129
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~24.42 miles northeast of Desoto
  • Low Cost Suburban property
  • 3 floors in hotel
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From£30
Average 3.0 /5 Latest Reviews Call BookMore Details
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Hampton Inn Farmington 850 Valley Creek Dr., Farmington, MO 63640
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~24.70 miles south of Desoto
  • Mid-scale Highway property
  • Check in time: 3:00pm
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From£60
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Super 8 by Wyndham Farmington 930 Valley Creek Dr., Farmington, MO 63640
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~24.77 miles south of Desoto
  • Cheap hotel
  • 2 floors in hotel
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From£37
Average 3.0 /5 Latest Reviews Call BookMore Details
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Holiday Inn Express & Suites Farmington by IHG in Farmington 820 Market St., Farmington, MO 63640
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~24.80 miles south of Desoto
  • Mid-scale Rural property
  • 60 sleeping rooms in hotel
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From£74
Very good 4.0 /5 Hotel Reviews Call BookMore Details
680 Fenton Business Park Ct Fenton Missouri 63026 Fenton Business Park Court Fenton, Fenton, IA 63026
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~25.48 miles north of Desoto
  • Mid-scale property
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From£60
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Quality Inn Farmington - Farmington 1400 West Liberty St., Farmington, MO 63640
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~25.62 miles south of Desoto
  • 3-star Rural property
  • Check in: 11:00
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From£60
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America's Best Inn Eureka in Eureka 1725 West 5th St., Eureka, MO 63025
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~25.87 miles north of Desoto
  • Inexpensive Highway hotel
  • Check in: 11.00am
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From£45
Poor 2.0 /5 Guest Reviews Call BookMore Details
Super 8 by Wyndham Eureka/Six Flags Nearby - Eureka 1733 West 5th St., Eureka, MO 63025
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~25.94 miles north of Desoto
  • Inexpensive Highway hotel
  • Check-in time: ex. 3:00 PM
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From£45
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Baymont Inn and Suites by Wyndham Farmington, MO in Farmington 1625 West Columbia St., Farmington, MO 63640
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~25.97 miles south of Desoto
  • Mid-scale Highway property
  • Check-in: 04:00
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From£60
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Fairfield Inn N Ste St. Louis South : 4318 Butler Hill Rd. 4318 Butler Hill Rd., St Louis, MO 63128
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~26.09 miles northeast of Desoto
  • 3 star property
  • Check in time: 15:00
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From£67
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Holiday Inn Express & Suites St. Louis South - I-55 by IHG - St. Louis 4250 Midamerica Ln, St. Louis, MO 63129
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~26.13 miles northeast of Desoto
  • Affordable Suburban hotel
  • 17 suites in property
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From£60
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Quality Inn Near Six Flags St. Louis in Pacific 1400 West Osage St., Pacific, MO 63069
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~26.17 miles northwest of Desoto
  • Three Star Rural hotel
  • 46 rooms in property
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From£60
Very good 4.0 /5 Latest Reviews Call BookMore Details
Hampton Inn & Suites St. Louis/South I-55 4200 Midamerica Ln, St. Louis, MO 63129
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~26.18 miles northeast of Desoto
  • 3 star Suburban hotel
  • 33 suites in hotel
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From£60
Very good 4.0 /5 Guest Reviews Call BookMore Details
Comfort Inn Near Six Flags St. Louis 1320 Thornton St., Pacific, MO 63069 Website
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~26.28 miles northwest of Desoto
  • Mid-scale Highway hotel
  • 3 floors in hotel
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From£66
Average 3.0 /5 Recent Reviews Call BookMore Details
Holiday Inn St. Louis West Six Flags by IHG in Eureka 4901 Six Flags Rd., Eureka, MO 63025
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~26.41 miles north of Desoto
  • Three Star Suburban property
  • Check-in: 04:00pm
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From£97
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Super 8 by Wyndham Waterloo in Waterloo 112 Warren Dr., Waterloo, IL 62298
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~26.68 miles northeast of Desoto
  • Two star Rural hotel
  • Check in: 3:00 PM
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From£45
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Super 8 by Wyndham St. Clair MO : 1010 South Outer Rd. 1010 South Outer Rd., Saint Clair, MO 63077
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~27.53 miles northwest of Desoto
  • Cheap Highway hotel
  • Check in: 3 PM
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From£45
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Pinemark Inn & Suites 866 South Outer Rd., St. Clair, MO 63077
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~27.60 miles northwest of Desoto
  • Economy Highway hotel
  • Free comp. breakfast
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From£46
Very good 4.0 /5 Read Reviews Call BookMore Details
Hampton Inn St. Louis Southwest : 9 Lambert Drury Place 9 Lambert Drury Place, St. Louis, MO 63088
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~27.66 miles north of Desoto
  • Three Star Suburban hotel
  • Access to gym on-site
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From£64
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Hampton Inn St. Louis Columbia in Columbia 165 Admiral Trost Dr., Columbia, IL 62236
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~27.76 miles northeast of Desoto
  • 3-star Suburban hotel
  • Fitness / Gym is on-site
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From£60
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Holiday Inn Express St. Louis West Fenton in Fenton 1848 Bowles Ave., Fenton, MO 63026
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~27.97 miles north of Desoto
  • 3 star Suburban hotel
  • Fitness center on property
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From£60
Very good 4.0 /5 Reviews Call BookMore Details
Motel 6 Fenton Mo - Fenton 1860 Bowles Ave., Fenton, MO 63026
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~27.99 miles north of Desoto
  • 2-star property
  • 58 rooms in hotel
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From£45
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Wingate by Wyndham St. Louis / Fenton Route 66 1100 South Highway Dr., Fenton, MO 63026
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~28.11 miles north of Desoto
  • Midscale Suburban hotel
  • Free complimentary breakfast
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From£60
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Heritage Inn & Suites St. Louis / Fenton Trademark by Wyndham 1088 South Highway Dr., Fenton, MO 63026
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~28.17 miles north of Desoto
  • Midscale Suburban property
  • Free comp. breakfast
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From£60
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Extended Stay America Suites St. Louis Fenton - Fenton 1662 Fenton Business Park Court, Fenton, MO 63026
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~28.25 miles north of Desoto
  • 3-star Suburban hotel
  • 3 floors in property
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From£60
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Americas Best Value Inn St. Louis South : 6602 South Lindbergh Blvd. 6602 South Lindbergh Blvd., St. Louis, MO 63123
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~28.28 miles northeast of Desoto
  • Two star Suburban hotel
  • Check in: 3:00 PM
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From£37
Poor 2.0 /5 Read Reviews Call BookMore Details
Best Western Plus Fenton : 1680 Fenton Business Park Court 1680 Fenton Business Park Court, Fenton, MO 63026
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~28.32 miles north of Desoto
  • 3-star Suburban property
  • Free breakfast
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From£46
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Super 8 by Wyndham Fenton/St. Louis Area 650 South Highway Dr., Fenton, MO 63026
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~28.34 miles north of Desoto
  • Economy property
  • Check in: 15:00
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From£45
Poor 2.0 /5 Recent Reviews Call BookMore Details
Aviator Hotel & Suites - St Louis 6921 South Lindbergh Blvd., St Louis, MO 63125
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~28.36 miles northeast of Desoto
  • Mid-scale Suburban property
  • Hotel has 4 floors
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From£60
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Comfort Suites St. Louis in St. Louis 3654 South Lindbergh Blvd., St. Louis, MO 63127
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~29.13 miles north of Desoto
  • Inexpensive Suburban hotel
  • Check-in time: 2:00 pm
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From£37
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Microtel Inn & Suites by Wyndham Sainte Genevieve - Ste. Genevieve 21958 State Highway 32, Ste. Genevieve, MO 63670
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~29.55 miles east of Desoto
  • Economical Highway property
  • Hotel has 48 rooms
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From£37
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Days Inn by Wyndham St. Louis Lindbergh Boulevard 3660 South Lindbergh Blvd., St Louis, MO 63127
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~29.61 miles north of Desoto
  • Affordable Suburban property
  • 2 floors in hotel
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From£52
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Holiday Inn St. Louis Sw Route 66 An Ihg Hotel in St. Louis 10709 Watson Rd., St. Louis, MO 63127
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~29.78 miles north of Desoto
  • Affordable Suburban hotel
  • Check in time: 4:00 PM
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From£59
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La Quinta Inn & Suites by Wyndham : 1580 South Kirkwood Rd. 1580 South Kirkwood Rd., Saint Louis, MO 63127
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~29.85 miles north of Desoto
  • Affordable Suburban property
  • Gym / Fitness Center Available
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From£75
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Best Western St. Louis-Kirkwood Route 66 1200 South Kirkwood Rd., Saint Louis, MO 63122
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~30.29 miles north of Desoto
  • 3 star Suburban property
  • Gym / Fitness Center Available
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From£52
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The Wildwood Hotel - Wildwood 2801 Fountain Place, Wildwood, MO 63040
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~30.75 miles north of Desoto
  • 4 star Suburban hotel
  • Check-in time: 04:00 PM
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From£75
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Super 8 by Wyndham Union 1015 East Main St., Union, MO 63084
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~31.92 miles northwest of Desoto
  • 2 star Rural hotel
  • Complimentary breakfast is offered
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From£50
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Courtyard by Marriott St. Louis West County in St. Louis 12815a Daylight Dr., St. Louis, MO 63131 Website
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~32.70 miles north of Desoto
  • Three Star Suburban hotel
  • 110 rooms in hotel
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From£59
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Next: See My Desoto Hotels with Pricing

Graph: Upcoming 20 Days of Desoto Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Desoto, MO discounts available. The chart reflects the cheapest Desoto hotel for each day and each star rating category.

FAQs about hotels in Desoto

What are the top rated hotels in Desoto?

Holiday Inn Club Vac Timber Creek, Hampton Inn St. Louis Southwest and Holiday Inn Express Hotel & Suites Festus South St. Louis by Ih are the best rated hotels based on customer reviews in the last 365 days.

What are the most high-end hotels in Desoto?

The Wildwood Hotel, Holiday Inn Club Vac Timber Creek and Comfort Inn Festus St. Louis South are the top 3 luxury hotels near Desoto city center.

What hotels are closest to the city center of Desoto?

Holiday Inn Club Vac Timber Creek, Holiday Inn Express Hotel & Suites Festus South St. Louis by Ih, and Comfort Inn Festus St. Louis South are the properties closest to Desoto city center.

What are the most popular independent hotels in Desoto?

Pinemark Inn & Suites, The Wildwood Hotel and America's Best Inn Eureka are the best rated independent hotels (not part of a big brand).

What are the most popular Marriott hotels in Desoto?

Courtyard by Marriott St. Louis West County and Fairfield Inn N Ste St. Louis South are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the most popular Choice Hotels branded hotels in Desoto?

Comfort Inn Festus St. Louis South, Woodspring Suites St. Louis Arnold and Quality Inn Near Six Flags St. Louis are the best rated Choice Hotels branded hotels (based on HotelPlanner reviews score).

What are the most popular Best Western hotels in Desoto?

Crown Pointe Lodge, BW Signature Collection, Best Western St. Louis-Kirkwood Route 66 and Best Western St. Louis Inn are the best rated Best Western branded hotels (based on user reviews score).

What are the most popular IHG hotels in Desoto?

Holiday Inn Club Vac Timber Creek, Holiday Inn Express Hotel & Suites Festus South St. Louis by Ih and Holiday Inn Express & Suites Farmington by IHG are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

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