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Desoto Missouri Accommodations

Find hotels in Desoto using the list and search tools below. Search for the cheapest discounted hotel and motel rates in or near Desoto, MO for your corporate or personal leisure travel. We show the best Desoto Missouri hotel rooms. Review the Desoto hotel list below to find the perfect lodging. We also have a map of the Desoto hotels.

Desoto Hotels, Motels & Accommodations

Holiday Inn Club Vac Timber Creek - Desoto 4800 Us Highway 67, Desoto, MO 63020
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  • 3 star hotel
  • 3 floors in property
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From£67
Very good 4.5 /5 Latest Reviews Call BookMore Details
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Holiday Inn Express Hotel & Suites Festus South St. Louis by Ih 1802 Gamel Cemetery Rd., Festus, MO 63028
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~9.28 miles northeast of Desoto
  • Economical Highway property
  • Free breakfast available
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From£67
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Comfort Inn Festus St. Louis South - Festus 1303 Veterans Blvd., Festus, MO 63028 Website
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~9.48 miles northeast of Desoto
  • 3-star Suburban hotel
  • 89 rooms in hotel
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From£33
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Baymont by Wyndham Festus : 1200 West Gannon Dr. 1200 West Gannon Dr., Festus, MO 63028
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~9.51 miles northeast of Desoto
  • 3 star Suburban hotel
  • Gym is available on property
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From£54
Average 3.0 /5 Recent Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham Festus - St. Louis South : 1001 Veterans Blvd. 1001 Veterans Blvd., Festus, MO 63028
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~9.70 miles northeast of Desoto
  • 3 star Suburban property
  • Free comp. breakfast
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From£60
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Super 8 by Wyndham Pevely 1711 Highway Z, Pevely, MO 63070
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~13.03 miles northeast of Desoto
  • Cheap property
  • Check in time: 11:00 AM
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From£26
Very good 4.0 /5 Latest Reviews Call BookMore Details
Super 8 by Wyndham Bonne Terre 8 Northwood Dr., Bonne Terre, MO 63628
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~14.93 miles south of Desoto
  • 2-star hotel
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From£45
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Motel 6 Bonne Terre Mo : 1017 Highway K 1017 Highway K, Bonne Terre, MO 63628
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~15.12 miles south of Desoto
  • 2-star hotel
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From£45
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Super 8 by Wyndham Potosi 820 East High St., Potosi, MO 63664
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~18.89 miles southwest of Desoto
  • Low Cost Highway hotel
  • Free complimentary breakfast
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From£37
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Quality Inn & Suites - Arnold 3610 West Outer Rd., Arnold, MO 63010 Website
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~20.97 miles northeast of Desoto
  • Low Cost Suburban hotel
  • Free breakfast available
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From£45
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Woodspring Suites St. Louis Arnold 888 Arnold Commons Dr., Arnold, MO 63010
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~22.46 miles northeast of Desoto
  • Low-priced Highway hotel
  • 124 sleeping rooms in hotel
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From£24
Very good 4.0 /5 Review Score Call BookMore Details
Crown Pointe Lodge, BW Signature Collection - Farmington 4245 Hunt Rd., Farmington, MO 63640
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~23.27 miles south of Desoto
  • Affordable Golf Course property
  • Hotel has 3 floors
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From£46
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Best Western St. Louis Inn 6224 Heimos Industrial Park Dr., Saint Louis, MO 63129
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~24.42 miles northeast of Desoto
  • 2-star Suburban property
  • Check-in time: 03:00
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From£30
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Hampton Inn Farmington : 850 Valley Creek Dr. 850 Valley Creek Dr., Farmington, MO 63640
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~24.70 miles south of Desoto
  • 3-star Highway hotel
  • Hotel has 3 floors
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From£60
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Super 8 by Wyndham Farmington in Farmington 930 Valley Creek Dr., Farmington, MO 63640
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~24.77 miles south of Desoto
  • 2 star property
  • Free breakfast
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From£37
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Holiday Inn Express & Suites Farmington by IHG : 820 Market St. 820 Market St., Farmington, MO 63640
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~24.80 miles south of Desoto
  • Mid-scale Rural hotel
  • Hotel has 3 floors
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From£74
Very good 4.0 /5 Reviews Call BookMore Details
680 Fenton Business Park Ct Fenton Missouri 63026 Fenton Business Park Court Fenton, Fenton, IA 63026
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~25.48 miles north of Desoto
  • Three Star property
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From£60
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Quality Inn Farmington : 1400 West Liberty St. 1400 West Liberty St., Farmington, MO 63640
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~25.62 miles south of Desoto
  • Mid-scale Rural hotel
  • Check-in: 11:00
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From£60
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America's Best Inn Eureka 1725 West 5th St., Eureka, MO 63025
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~25.87 miles north of Desoto
  • Low priced Highway hotel
  • Check-in time: 11.00am
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From£45
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Super 8 by Wyndham Eureka/Six Flags Nearby - Eureka 1733 West 5th St., Eureka, MO 63025
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~25.94 miles north of Desoto
  • Two-star Highway hotel
  • Check in time: ex. 3:00 PM
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From£45
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Baymont Inn and Suites by Wyndham Farmington, MO - Farmington 1625 West Columbia St., Farmington, MO 63640
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~25.97 miles south of Desoto
  • Midscale Highway hotel
  • Hotel has 2 suites
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From£60
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Fairfield Inn N Ste St. Louis South in St Louis 4318 Butler Hill Rd., St Louis, MO 63128
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~26.09 miles northeast of Desoto
  • Midscale hotel
  • Hotel has 77 rooms
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From£67
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Holiday Inn Express & Suites St. Louis South - I-55 by IHG - St. Louis 4250 Midamerica Ln, St. Louis, MO 63129
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~26.13 miles northeast of Desoto
  • 3 star Suburban property
  • Hotel has an eco-friendly policy Read more
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From£60
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Quality Inn Near Six Flags St. Louis : 1400 West Osage St. 1400 West Osage St., Pacific, MO 63069
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~26.17 miles northwest of Desoto
  • Affordable Rural property
  • Check-in: 11:00
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From£60
Very good 4.0 /5 Review Score Call BookMore Details
Hampton Inn & Suites St. Louis/South I-55 4200 Midamerica Ln, St. Louis, MO 63129
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~26.18 miles northeast of Desoto
  • Three Star Suburban property
  • 92 sleeping rooms in hotel
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From£60
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Comfort Inn Near Six Flags St. Louis in Pacific 1320 Thornton St., Pacific, MO 63069 Website
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~26.28 miles northwest of Desoto
  • 3-star Highway hotel
  • 70 rooms in property
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From£66
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Holiday Inn St. Louis West Six Flags by IHG : 4901 Six Flags Rd. 4901 Six Flags Rd., Eureka, MO 63025
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~26.41 miles north of Desoto
  • 3-star Suburban hotel
  • Check in: 04:00pm
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From£97
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Super 8 by Wyndham Waterloo 112 Warren Dr., Waterloo, IL 62298
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~26.68 miles northeast of Desoto
  • Economy Rural hotel
  • Check-in: 3:00 PM
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From£45
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Super 8 by Wyndham St. Clair MO - Saint Clair 1010 South Outer Rd., Saint Clair, MO 63077
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~27.53 miles northwest of Desoto
  • Inexpensive Highway property
  • Check in: 3 PM
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From£45
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Pinemark Inn & Suites - St. Clair 866 South Outer Rd., St. Clair, MO 63077
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~27.60 miles northwest of Desoto
  • Low Cost Highway hotel
  • 2 floors in hotel
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From£46
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Hampton Inn St. Louis Southwest : 9 Lambert Drury Place 9 Lambert Drury Place, St. Louis, MO 63088
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~27.66 miles north of Desoto
  • Affordable Suburban property
  • Free breakfast
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From£64
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Hampton Inn St. Louis Columbia in Columbia 165 Admiral Trost Dr., Columbia, IL 62236
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~27.76 miles northeast of Desoto
  • 3 star Suburban hotel
  • 77 sleeping rooms in hotel
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From£60
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Holiday Inn Express St. Louis West Fenton 1848 Bowles Ave., Fenton, MO 63026
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~27.97 miles north of Desoto
  • Affordable Suburban property
  • Gym / Fitness Center Available
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From£60
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Motel 6 Fenton Mo 1860 Bowles Ave., Fenton, MO 63026
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~27.99 miles north of Desoto
  • Inexpensive hotel
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From£45
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Wingate by Wyndham St. Louis / Fenton Route 66 : 1100 South Highway Dr. 1100 South Highway Dr., Fenton, MO 63026
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~28.11 miles north of Desoto
  • Three Star Suburban hotel
  • Hotel has an eco-friendly policy See policy
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From£60
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Heritage Inn & Suites St. Louis / Fenton Trademark by Wyndham in Fenton 1088 South Highway Dr., Fenton, MO 63026
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~28.17 miles north of Desoto
  • Affordable Suburban hotel
  • Fitness + Health Center
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From£60
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Extended Stay America Suites St. Louis Fenton 1662 Fenton Business Park Court, Fenton, MO 63026
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~28.25 miles north of Desoto
  • Midscale Suburban hotel
  • Hotel has 94 suites
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From£60
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Americas Best Value Inn St. Louis South - St. Louis 6602 South Lindbergh Blvd., St. Louis, MO 63123
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~28.28 miles northeast of Desoto
  • Economical Suburban property
  • Check in time: 3:00 PM
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From£37
Poor 2.0 /5 Read Reviews Call BookMore Details
Best Western Plus Fenton 1680 Fenton Business Park Court, Fenton, MO 63026
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~28.32 miles north of Desoto
  • 3 star Suburban hotel
  • Comp. Breakfast
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From£46
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Super 8 by Wyndham Fenton/St. Louis Area 650 South Highway Dr., Fenton, MO 63026
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~28.34 miles north of Desoto
  • Inexpensive hotel
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From£45
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Aviator Hotel & Suites - St Louis 6921 South Lindbergh Blvd., St Louis, MO 63125
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~28.36 miles northeast of Desoto
  • Mid-scale Suburban property
  • Check-in: 04:00
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From£60
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Comfort Suites St. Louis - St. Louis 3654 South Lindbergh Blvd., St. Louis, MO 63127
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~29.13 miles north of Desoto
  • Low-priced Suburban hotel
  • Hotel has 160 rooms
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From£37
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Microtel Inn & Suites by Wyndham Sainte Genevieve 21958 State Highway 32, Ste. Genevieve, MO 63670
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~29.55 miles east of Desoto
  • Low Cost Highway property
  • Hotel has 2 floors
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From£37
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Days Inn by Wyndham St. Louis Lindbergh Boulevard : 3660 South Lindbergh Blvd. 3660 South Lindbergh Blvd., St Louis, MO 63127
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~29.61 miles north of Desoto
  • Affordable Suburban hotel
  • Hotel has 2 floors
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From£52
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Holiday Inn St. Louis Sw Route 66 An Ihg Hotel in St. Louis 10709 Watson Rd., St. Louis, MO 63127
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~29.78 miles north of Desoto
  • 3 star Suburban property
  • Fitness center on property
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From£59
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La Quinta Inn & Suites by Wyndham 1580 South Kirkwood Rd., Saint Louis, MO 63127
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~29.85 miles north of Desoto
  • Affordable Suburban hotel
  • Fitness + Health Center
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From£75
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Best Western St. Louis-Kirkwood Route 66 1200 South Kirkwood Rd., Saint Louis, MO 63122
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~30.29 miles north of Desoto
  • Three Star Suburban property
  • 6 floors in property
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From£52
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The Wildwood Hotel in Wildwood 2801 Fountain Place, Wildwood, MO 63040
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~30.75 miles north of Desoto
  • Four star Suburban property
  • Fitness + Health Center
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From£75
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Super 8 by Wyndham Union : 1015 East Main St. 1015 East Main St., Union, MO 63084
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~31.92 miles northwest of Desoto
  • Inexpensive Rural hotel
  • Check in: 11:00 AM
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From£50
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Courtyard by Marriott St. Louis West County - St. Louis 12815a Daylight Dr., St. Louis, MO 63131 Website
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~32.70 miles north of Desoto
  • Midscale Suburban property
  • Hotel has 110 rooms
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From£59
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Next: See My Desoto Hotels with Pricing

Graph: Upcoming 20 Days of Desoto Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Desoto, MO discounts available. The chart reflects the cheapest Desoto hotel for each day and each star rating category.

FAQs about hotels in Desoto

What are the top rated hotels in Desoto?

Holiday Inn Club Vac Timber Creek, Hampton Inn St. Louis Southwest and Holiday Inn Express Hotel & Suites Festus South St. Louis by Ih are the best rated hotels based on customer reviews in the last 365 days.

What are the most high-end hotels in Desoto?

The Wildwood Hotel, Holiday Inn Club Vac Timber Creek and Comfort Inn Festus St. Louis South are the top 3 luxury hotels near Desoto city center.

What hotels are closest to the city center of Desoto?

Holiday Inn Club Vac Timber Creek, Holiday Inn Express Hotel & Suites Festus South St. Louis by Ih, and Comfort Inn Festus St. Louis South are the properties closest to Desoto city center.

What are the most popular independent hotels in Desoto?

Pinemark Inn & Suites, The Wildwood Hotel and America's Best Inn Eureka are the best rated independent hotels (not part of a big brand).

What are the most popular Marriott hotels in Desoto?

Courtyard by Marriott St. Louis West County and Fairfield Inn N Ste St. Louis South are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the most popular Choice Hotels branded hotels in Desoto?

Comfort Inn Festus St. Louis South, Woodspring Suites St. Louis Arnold and Quality Inn Near Six Flags St. Louis are the best rated Choice Hotels branded hotels (based on HotelPlanner reviews score).

What are the most popular Best Western hotels in Desoto?

Crown Pointe Lodge, BW Signature Collection, Best Western St. Louis-Kirkwood Route 66 and Best Western St. Louis Inn are the best rated Best Western branded hotels (based on user reviews score).

What are the most popular IHG hotels in Desoto?

Holiday Inn Club Vac Timber Creek, Holiday Inn Express Hotel & Suites Festus South St. Louis by Ih and Holiday Inn Express & Suites Farmington by IHG are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

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