Desoto Missouri Accommodations

Find hotels in Desoto using the list and search tools below. Search for the cheapest discounted hotel and motel rates in or near Desoto, MO for your corporate or personal leisure travel. We show the best Desoto Missouri hotel rooms. Review the Desoto hotel list below to find the perfect lodging. We also have a map of the Desoto hotels.

Desoto Hotels, Motels & Accommodations

Holiday Inn Club Vac Timber Creek 4800 Us Highway 67, Desoto, MO 63020 Call
  • Midscale hotel
  • 72 rooms in property
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From£79 total
Very good 4.5 /5 Guest Reviews Call BookMore Details
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IH 1802 Gamel Cemetery Rd., Festus, MO 63028 Call ~9.28 miles northeast of Desoto
  • Two-star Highway hotel
  • Check in: 3:00pm
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From£79 total
Very good 4.0 /5 Read Reviews Call BookMore Details
Comfort Inn Festus 1303 Veterans Blvd., Festus, MO 63028 Website Call ~9.48 miles northeast of Desoto
  • 3-star Suburban hotel
  • 5 suites in property
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From£70 total
Average 3.0 /5 Recent Reviews Call BookMore Details
Baymont by Wyndham Festus : 1200 West Gannon Dr. 1200 West Gannon Dr., Festus, MO 63028 Call ~9.51 miles northeast of Desoto
  • Affordable Suburban hotel
  • 7 meeting rooms in hotel
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From£63 total
Average 3.0 /5 Guest Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham Festus - St. Louis South in Festus 1001 Veterans Blvd., Festus, MO 63028 Call ~9.70 miles northeast of Desoto
  • 3-star Suburban hotel
  • Check-in: 3:00 PM
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From£70 total
Average 3.0 /5 Review Score Call BookMore Details
Super 8 by Wyndham Pevely 1711 Highway Z, Pevely, MO 63070 Call ~13.03 miles northeast of Desoto
  • Low-priced hotel
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From£31 total
Very good 4.0 /5 Latest Reviews Call BookMore Details
Super 8 by Wyndham Bonne Terre 8 Northwood Dr., Bonne Terre, MO 63628 Call ~14.93 miles south of Desoto
  • Economy hotel
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From£53 total
Average 3.0 /5 Hotel Reviews Call BookMore Details
Motel 6 Bonne Terre Mo - Bonne Terre 1017 Highway K, Bonne Terre, MO 63628 Call ~15.12 miles south of Desoto
  • Cheap hotel
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From£53 total
Average 3.0 /5 Review Score Call BookMore Details
Super 8 by Wyndham Potosi : 820 East High St. 820 East High St., Potosi, MO 63664 Call ~18.89 miles southwest of Desoto
  • Economical Highway hotel
  • 48 rooms in hotel
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From£43 total
Average 3.0 /5 Hotel Reviews Call BookMore Details
Quality Inn & Suites 3610 West Outer Rd., Arnold, MO 63010 Call ~20.97 miles northeast of Desoto
  • Economical Suburban hotel
  • Hotel has 2 meeting rooms
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From£53 total
Average 3.0 /5 Guest Reviews Call BookMore Details
Woodspring Suites St. Louis Arnold - Arnold 888 Arnold Commons Dr., Arnold, MO 63010 Call ~22.46 miles northeast of Desoto
  • Economy Highway property
  • 4 floors in hotel
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From£28 total
Very good 4.0 /5 Reviews Call BookMore Details
Crown Pointe Lodge, BW Signature Collection 4245 Hunt Rd., Farmington, MO 63640 Call ~23.27 miles south of Desoto
  • Affordable Golf Course hotel
  • Free complimentary breakfast
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From£54 total
Very good 4.0 /5 Reviews Call BookMore Details
Best Western St. Louis Inn in Saint Louis 6224 Heimos Industrial Park Dr., Saint Louis, MO 63129 Call ~24.42 miles northeast of Desoto
  • Low Cost Suburban property
  • Hotel has 87 rooms
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From£35 total
Average 3.0 /5 Hotel Reviews Call BookMore Details
Hampton Inn Farmington - Farmington 850 Valley Creek Dr., Farmington, MO 63640 Call ~24.70 miles south of Desoto
  • Mid-scale Highway property
  • 3 floors in property
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From£70 total
Average 3.0 /5 Recent Reviews Call BookMore Details
Super 8 by Wyndham Farmington 930 Valley Creek Dr., Farmington, MO 63640 Call ~24.77 miles south of Desoto
  • Low-priced hotel
  • Hotel has 2 floors
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From£43 total
Average 3.0 /5 Latest Reviews Call BookMore Details
Holiday Inn Express & Suites Farmington by IHG 820 Market St., Farmington, MO 63640 Call ~24.80 miles south of Desoto
  • Mid-scale Rural property
  • Check in time: 3:00pm
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From£87 total
Very good 4.0 /5 Reviews Call BookMore Details
680 Fenton Business Park Ct Fenton Missouri 63026 - Fenton Fenton Business Park Court Fenton, Fenton, IA 63026 Call ~25.48 miles north of Desoto
  • Mid-scale hotel
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From£70 total
Average 3.0 /5 Reviews Call BookMore Details
Quality Inn Farmington 1400 West Liberty St., Farmington, MO 63640 Call ~25.62 miles south of Desoto
  • Mid-scale Rural property
  • 48 sleeping rooms in hotel
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From£70 total
Average 3.0 /5 Hotel Reviews Call BookMore Details
America's Best Inn Eureka - Eureka 1725 West 5th St., Eureka, MO 63025 Call ~25.87 miles north of Desoto
  • Low priced Highway property
  • Check in: 11.00am
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From£53 total
Poor 2.0 /5 Review Score Call BookMore Details
Super 8 by Wyndham Eureka/Six Flags Nearby 1733 West 5th St., Eureka, MO 63025 Call ~25.94 miles north of Desoto
  • 2-star Highway property
  • Check-in time: ex. 3:00 PM
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From£53 total
Average 3.0 /5 Hotel Reviews Call BookMore Details
Baymont Inn and Suites by Wyndham Farmington, MO 1625 West Columbia St., Farmington, MO 63640 Call ~25.97 miles south of Desoto
  • 3 star Highway property
  • 94 rooms in hotel
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From£70 total
Average 3.0 /5 Review Score Call BookMore Details
Fairfield Inn N Ste St. Louis South 4318 Butler Hill Rd., St Louis, MO 63128 Call ~26.09 miles northeast of Desoto
  • Midscale hotel
  • 77 rooms in property
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From£79 total
Average 3.0 /5 Guest Reviews Call BookMore Details
Holiday Inn Express & Suites St. Louis South I 55 by IHG 4250 Midamerica Ln, St. Louis, MO 63129 Call ~26.13 miles northeast of Desoto
  • Three Star Suburban property
  • 99 sleeping rooms in hotel
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From£70 total
Average 3.0 /5 Latest Reviews Call BookMore Details
Quality Inn Near Six Flags St. Louis : 1400 West Osage St. 1400 West Osage St., Pacific, MO 63069 Call ~26.17 miles northwest of Desoto
  • Three Star Rural property
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From£70 total
Very good 4.0 /5 Read Reviews Call BookMore Details
Hampton Inn & Suites St. Louis / South I 55 4200 Midamerica Ln, St. Louis, MO 63129 Call ~26.18 miles northeast of Desoto
  • Affordable Suburban property
  • Hotel has 33 suites
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From£70 total
Very good 4.0 /5 Recent Reviews Call BookMore Details
Comfort Inn Near Six Flags St. Louis 1320 Thornton St., Pacific, MO 63069 Call ~26.28 miles northwest of Desoto
  • Mid-scale Highway property
  • Check in time: 3:00PM
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From£78 total
Average 3.0 /5 Review Score Call BookMore Details
Holiday Inn St. Louis West Six Flags by IHG 4901 Six Flags Rd., Eureka, MO 63025 Call ~26.41 miles north of Desoto
  • Affordable Suburban property
  • 4 meeting rooms in hotel
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From£114 total
Average 3.0 /5 Reviews Call BookMore Details
Super 8 by Wyndham Waterloo in Waterloo 112 Warren Dr., Waterloo, IL 62298 Call ~26.68 miles northeast of Desoto
  • 2-star Rural property
  • Free comp. breakfast
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From£53 total
Average 3.5 /5 Guest Reviews Call BookMore Details
Super 8 by Wyndham St. Clair MO in Saint Clair 1010 South Outer Rd., Saint Clair, MO 63077 Call ~27.53 miles northwest of Desoto
  • Two-star Highway property
  • Hotel has 2 suites
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From£53 total
Average 3.0 /5 Latest Reviews Call BookMore Details
Pinemark Inn & Suites : 866 South Outer Rd. 866 South Outer Rd., St. Clair, MO 63077 Call ~27.60 miles northwest of Desoto
  • Economy Highway property
  • 3 suites in property
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From£54 total
Very good 4.0 /5 Recent Reviews Call BookMore Details
Hampton Inn St. Louis Southwest - St. Louis 9 Lambert Drury Place, St. Louis, MO 63088 Call ~27.66 miles north of Desoto
  • Three Star Suburban hotel
  • Hotel has 92 rooms
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From£75 total
Very good 4.5 /5 Recent Reviews Call BookMore Details
Hampton Inn St. Louis Columbia 165 Admiral Trost Dr., Columbia, IL 62236 Call ~27.76 miles northeast of Desoto
  • 3-star Suburban property
  • Check-in time: 3:00 PM
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From£70 total
Average 3.0 /5 Review Score Call BookMore Details
Holiday Inn Express & Suites St. Louis West - Fenton by IHG 1848 Bowles Ave., Fenton, MO 63026 Call ~27.97 miles north of Desoto
  • 3-star Suburban property
  • Check in time: 03:00 PM
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From£70 total
Very good 4.0 /5 Guest Reviews Call BookMore Details
Motel 6 Fenton Mo 1860 Bowles Ave., Fenton, MO 63026 Call ~27.99 miles north of Desoto
  • Low priced hotel
  • 58 rooms in hotel
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From£53 total
Average 3.0 /5 Guest Reviews Call BookMore Details
Wingate by Wyndham St. Louis / Fenton Route 66 1100 South Highway Dr., Fenton, MO 63026 Call ~28.11 miles north of Desoto
  • Three Star Suburban property
  • Fitness / Gym is on-site
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From£70 total
Average 3.0 /5 Read Reviews Call BookMore Details
Heritage Inn & Suites St. Louis / Fenton Trademark by Wyndham - Fenton 1088 South Highway Dr., Fenton, MO 63026 Call ~28.17 miles north of Desoto
  • Mid-scale Suburban hotel
  • Hotel has a green policy See more
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From£70 total
Average 3.0 /5 Guest Reviews Call BookMore Details
Extended Stay America Suites St. Louis Fenton : 1662 Fenton Business Park Court 1662 Fenton Business Park Court, Fenton, MO 63026 Call ~28.25 miles north of Desoto
  • Three Star Suburban hotel
  • 3 floors in hotel
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From£70 total
Average 3.0 /5 Review Score Call BookMore Details
Americas Best Value Inn St. Louis South 6602 South Lindbergh Blvd., St. Louis, MO 63123 Call ~28.28 miles northeast of Desoto
  • Low-priced Suburban property
  • Check-in: 3:00 PM
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From£43 total
Poor 2.0 /5 Review Score Call BookMore Details
Best Western Plus Fenton 1680 Fenton Business Park Court, Fenton, MO 63026 Call ~28.32 miles north of Desoto
  • Three Star Suburban hotel
  • Gym is available on property
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From£54 total
Average 3.0 /5 Latest Reviews Call BookMore Details
Super 8 by Wyndham Fenton/St. Louis Area 650 South Highway Dr., Fenton, MO 63026 Call ~28.34 miles north of Desoto
  • Cheap property
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From£53 total
Poor 2.0 /5 Read Reviews Call BookMore Details
Aviator Hotel & Suites 6921 South Lindbergh Blvd., St Louis, MO 63125 Call ~28.36 miles northeast of Desoto
  • Midscale Suburban hotel
  • Check-in: 04:00
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From£70 total
Average 3.0 /5 Review Score Call BookMore Details
Comfort Suites St. Louis - St. Louis 3654 South Lindbergh Blvd., St. Louis, MO 63127 Call ~29.13 miles north of Desoto
  • Economical Suburban hotel
  • Hotel has 160 rooms
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From£43 total
Average 3.5 /5 Guest Reviews Call BookMore Details
Microtel Inn & Suites by Wyndham Sainte Genevieve 21958 State Highway 32, Ste. Genevieve, MO 63670 Call ~29.55 miles east of Desoto
  • Two star Highway hotel
  • 6 suites in hotel
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From£44 total
Average 3.0 /5 Guest Reviews Call BookMore Details
Days Inn by Wyndham St. Louis Lindbergh Boulevard 3660 South Lindbergh Blvd., St Louis, MO 63127 Call ~29.61 miles north of Desoto
  • Affordable Suburban hotel
  • Comp. Breakfast
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From£61 total
Average 3.0 /5 Latest Reviews Call BookMore Details
Holiday Inn St. Louis Sw Route 66 An Ihg Hotel 10709 Watson Rd., St. Louis, MO 63127 Call ~29.78 miles north of Desoto
  • Midscale Suburban hotel
  • Hotel has an eco-friendly policy Learn more
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From£70 total
Average 3.0 /5 Guest Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham 1580 South Kirkwood Rd., Saint Louis, MO 63127 Call ~29.85 miles north of Desoto
  • 3 star Suburban hotel
  • Free complimentary breakfast
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From£88 total
Average 3.0 /5 Reviews Call BookMore Details
Best Western St. Louis-Kirkwood Route 66 - Saint Louis 1200 South Kirkwood Rd., Saint Louis, MO 63122 Call ~30.29 miles north of Desoto
  • Mid-scale Suburban hotel
  • Fitness / Gym is on-site
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From£62 total
Very good 4.0 /5 Hotel Reviews Call BookMore Details
The Wildwood Hotel - Wildwood 2801 Fountain Place, Wildwood, MO 63040 Call ~30.75 miles north of Desoto
  • High end Suburban property
  • Fitness / Gym is on-site
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From£88 total
Very good 4.0 /5 Recent Reviews Call BookMore Details
Super 8 by Wyndham Union 1015 East Main St., Union, MO 63084 Call ~31.92 miles northwest of Desoto
  • Cheap Rural property
  • Complimentary breakfast is offered
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From£59 total
Average 3.0 /5 Latest Reviews Call BookMore Details
Courtyard by Marriott St. Louis West County - St. Louis 12815a Daylight Dr., St. Louis, MO 63131 Website Call ~32.70 miles north of Desoto
  • Affordable Suburban property
  • 3 meeting rooms in hotel
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From£70 total
Very good 4.0 /5 Hotel Reviews Call BookMore Details

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