Desoto Missouri Accommodations

Find hotels in Desoto using the list and search tools below. Search for the cheapest discounted hotel and motel rates in or near Desoto, MO for your corporate or personal leisure travel. We show the best Desoto Missouri hotel rooms. Review the Desoto hotel list below to find the perfect lodging. We also have a map of the Desoto hotels.

Desoto Hotels/Motels & Accommodations

Holiday Inn Club Vac Timber Creek - Desoto 4800 Us Highway 67, Desoto, MO 63020 Call
  • Affordable property
  • 3 floors in property
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From£66
Very good 4.5 /5 Reviews Call BookMore Details
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IH - Festus 1802 Gamel Cemetery Rd., Festus, MO 63028 Call ~9.28 miles northeast of Desoto
  • Two star Highway hotel
  • 85 rooms in hotel
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From£66
Very good 4.0 /5 Guest Reviews Call BookMore Details
Comfort Inn Festus St. Louis South : 1303 Veterans Blvd. 1303 Veterans Blvd., Festus, MO 63028 Website Call ~9.48 miles northeast of Desoto
  • 3-star Suburban hotel
  • 5 suites in property
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From£33
Very good 4.0 /5 Read Reviews Call BookMore Details
Baymont by Wyndham Festus in Festus 1200 West Gannon Dr., Festus, MO 63028 Call ~9.51 miles northeast of Desoto
  • Mid-scale Suburban property
  • Hotel has 7 meeting rooms
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From£53
Average 3.0 /5 Review Score Call BookMore Details
La Quinta Inn & Suites by Wyndham Festus - St. Louis South in Festus 1001 Veterans Blvd., Festus, MO 63028 Call ~9.70 miles northeast of Desoto
  • Mid-scale Suburban hotel
  • Check in: 3:00 PM
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From£59
Average 3.0 /5 Latest Reviews Call BookMore Details
Super 8 by Wyndham Pevely : 1711 Highway Z 1711 Highway Z, Pevely, MO 63070 Call ~13.03 miles northeast of Desoto
  • Inexpensive property
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From£26
Very good 4.0 /5 Review Score Call BookMore Details
Super 8 by Wyndham Bonne Terre 8 Northwood Dr., Bonne Terre, MO 63628 Call ~14.93 miles south of Desoto
  • Two star property
  • Check in: 11:00 AM
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From£44
Average 3.0 /5 Review Score Call BookMore Details
Motel 6 Bonne Terre Mo - Bonne Terre 1017 Highway K, Bonne Terre, MO 63628 Call ~15.12 miles south of Desoto
  • Economical hotel
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From£44
Average 3.0 /5 Recent Reviews Call BookMore Details
Super 8 by Wyndham Potosi - Potosi 820 East High St., Potosi, MO 63664 Call ~18.89 miles southwest of Desoto
  • Cheap Highway hotel
  • Check-in time: 2 pm
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From£36
Average 3.0 /5 Guest Reviews Call BookMore Details
Quality Inn & Suites : 3610 West Outer Rd. 3610 West Outer Rd., Arnold, MO 63010 Website Call ~20.97 miles northeast of Desoto
  • Economical Suburban property
  • Hotel has 19 suites
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From£44
Average 3.0 /5 Guest Reviews Call BookMore Details
Woodspring Suites St. Louis Arnold 888 Arnold Commons Dr., Arnold, MO 63010 Call ~22.46 miles northeast of Desoto
  • Cheap Highway property
  • 124 sleeping rooms in hotel
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From£23
Very good 4.0 /5 Recent Reviews Call BookMore Details
Drury Inn & Suites St. Louis Arnold in Arnold 3800 State Rt 141, Arnold, MO 63010 Call ~22.57 miles northeast of Desoto
  • Mid-scale Suburban hotel
  • Check in: 3:00 pm
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From£91
Excellent 5.0 /5 Hotel Reviews Call BookMore Details
Pear Tree Inn St. Louis Arnold - Arnold 1201 Drury Lane, Arnold, MO 63010 Call ~23.16 miles northeast of Desoto
  • Mid-scale Suburban property
  • 4 meeting rooms in hotel
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From£59
Very good 4.0 /5 Review Score Call BookMore Details
Crown Pointe Lodge, BW Signature Collection - Farmington 4245 Hunt Rd., Farmington, MO 63640 Call ~23.27 miles south of Desoto
  • Midscale Golf Course property
  • 17 suites in property
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From£47
Very good 4.0 /5 Reviews Call BookMore Details
Best Western St. Louis Inn : 6224 Heimos Industrial Park Dr. 6224 Heimos Industrial Park Dr., Saint Louis, MO 63129 Call ~24.42 miles northeast of Desoto
  • Two star Suburban property
  • Hotel has 87 rooms
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From£30
Average 3.0 /5 Latest Reviews Call BookMore Details
Hampton Inn Farmington : 850 Valley Creek Dr. 850 Valley Creek Dr., Farmington, MO 63640 Call ~24.70 miles south of Desoto
  • 3 star Highway property
  • 3 floors in hotel
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From£59
Average 3.0 /5 Review Score Call BookMore Details
Super 8 by Wyndham Farmington - Farmington 930 Valley Creek Dr., Farmington, MO 63640 Call ~24.77 miles south of Desoto
  • Two-star hotel
  • 60 rooms in property
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From£36
Average 3.0 /5 Reviews Call BookMore Details
Holiday Inn Express & Suites Farmington by IHG : 820 Market St. 820 Market St., Farmington, MO 63640 Call ~24.80 miles south of Desoto
  • Three Star Rural property
  • Hotel has 20 suites
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From£73
Very good 4.0 /5 Reviews Call BookMore Details
680 Fenton Business Park Ct Fenton Missouri 63026 Fenton Business Park Court Fenton, Fenton, IA 63026 Call ~25.48 miles north of Desoto
  • 3 star hotel
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From£59
Average 3.0 /5 Review Score Call BookMore Details
Quality Inn Farmington : 1400 West Liberty St. 1400 West Liberty St., Farmington, MO 63640 Call ~25.62 miles south of Desoto
  • 3-star Rural hotel
  • Check in: 11:00
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From£59
Average 3.0 /5 Guest Reviews Call BookMore Details
America's Best Inn Eureka 1725 West 5th St., Eureka, MO 63025 Call ~25.87 miles north of Desoto
  • Cheap Highway property
  • Check in: 11.00am
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From£44
Poor 2.0 /5 Reviews Call BookMore Details
Super 8 by Wyndham Eureka/Six Flags Nearby 1733 West 5th St., Eureka, MO 63025 Call ~25.94 miles north of Desoto
  • 2 star Highway hotel
  • Check-in: ex. 3:00 PM
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From£44
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Baymont Inn and Suites by Wyndham Farmington, MO 1625 West Columbia St., Farmington, MO 63640 Call ~25.97 miles south of Desoto
  • 3 star Highway property
  • 2 suites in hotel
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From£59
Average 3.0 /5 Hotel Reviews Call BookMore Details
Fairfield Inn N Ste St. Louis South 4318 Butler Hill Rd., St Louis, MO 63128 Call ~26.09 miles northeast of Desoto
  • 3-star hotel
  • Check-in time: 15:00
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From£66
Average 3.0 /5 Hotel Reviews Call BookMore Details
Holiday Inn Express & Suites St. Louis South I 55 by IHG in St. Louis 4250 Midamerica Ln, St. Louis, MO 63129 Call ~26.13 miles northeast of Desoto
  • Three Star Suburban hotel
  • Has environment-friendly policy Read more
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From£59
Average 3.0 /5 Review Score Call BookMore Details
Quality Inn Near Six Flags St. Louis 1400 West Osage St., Pacific, MO 63069 Call ~26.17 miles northwest of Desoto
  • Affordable Rural property
  • 46 rooms in property
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From£59
Very good 4.0 /5 Reviews Call BookMore Details
Hampton Inn & Suites St. Louis/South I-55 : 4200 Midamerica Ln 4200 Midamerica Ln, St. Louis, MO 63129 Call ~26.18 miles northeast of Desoto
  • 3-star Suburban property
  • Comp. Breakfast
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From£59
Very good 4.0 /5 Reviews Call BookMore Details
Comfort Inn Near Six Flags St. Louis in Pacific 1320 Thornton St., Pacific, MO 63069 Website Call ~26.28 miles northwest of Desoto
  • 3-star Highway hotel
  • Free comp. breakfast
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From£65
Average 3.0 /5 Reviews Call BookMore Details
Holiday Inn St. Louis West Six Flags by IHG - Eureka 4901 Six Flags Rd., Eureka, MO 63025 Call ~26.41 miles north of Desoto
  • 3 star Suburban hotel
  • 179 rooms in property
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From£95
Average 3.0 /5 Guest Reviews Call BookMore Details
Super 8 by Wyndham Waterloo : 112 Warren Dr. 112 Warren Dr., Waterloo, IL 62298 Call ~26.68 miles northeast of Desoto
  • Cheap Rural property
  • Free complimentary breakfast
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From£44
Average 3.5 /5 Reviews Call BookMore Details
Super 8 by Wyndham St. Clair MO 1010 South Outer Rd., Saint Clair, MO 63077 Call ~27.53 miles northwest of Desoto
  • Economical Highway hotel
  • Hotel has 3 floors
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From£44
Average 3.0 /5 Review Score Call BookMore Details
Pinemark Inn & Suites - St. Clair 866 South Outer Rd., St. Clair, MO 63077 Call ~27.60 miles northwest of Desoto
  • 2 star Highway hotel
  • Complimentary breakfast is offered
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From£45
Very good 4.0 /5 Read Reviews Call BookMore Details
Hampton Inn St. Louis Southwest 9 Lambert Drury Place, St. Louis, MO 63088 Call ~27.66 miles north of Desoto
  • Midscale Suburban hotel
  • Fitness / Gym is on-site
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From£63
Very good 4.5 /5 Read Reviews Call BookMore Details
Drury Inn & Suites St. Louis Southwest in St. Louis 5 Lambert Drury Place (I 44 & 141), St. Louis, MO 63088 Call ~27.66 miles north of Desoto
  • Mid-scale Suburban hotel
  • Hotel has 7 floors
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From£62
Very good 4.5 /5 Reviews Call BookMore Details
Hampton Inn St. Louis Columbia 165 Admiral Trost Dr., Columbia, IL 62236 Call ~27.76 miles northeast of Desoto
  • Mid-scale Suburban property
  • 3 floors in hotel
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From£59
Average 3.0 /5 Hotel Reviews Call BookMore Details
Holiday Inn Express & Suites St. Louis West - Fenton by IHG 1848 Bowles Ave., Fenton, MO 63026 Call ~27.97 miles north of Desoto
  • 3 star Suburban hotel
  • Hotel has 14 suites
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From£59
Very good 4.0 /5 Review Score Call BookMore Details
Motel 6 Fenton Mo - Fenton 1860 Bowles Ave., Fenton, MO 63026 Call ~27.99 miles north of Desoto
  • 2-star property
  • 58 sleeping rooms in hotel
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From£44
Average 3.0 /5 Hotel Reviews Call BookMore Details
Wingate by Wyndham St. Louis / Fenton Route 66 - Fenton 1100 South Highway Dr., Fenton, MO 63026 Call ~28.11 miles north of Desoto
  • Mid-scale Suburban hotel
  • Check in time: 3:00 PM
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From£59
Average 3.0 /5 Recent Reviews Call BookMore Details
Heritage Inn & Suites St. Louis / Fenton Trademark by Wyndham : 1088 South Highway Dr. 1088 South Highway Dr., Fenton, MO 63026 Call ~28.17 miles north of Desoto
  • 3 star Suburban hotel
  • Hotel has 3 meeting rooms
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From£59
Average 3.0 /5 Hotel Reviews Call BookMore Details
Extended Stay America Suites St. Louis Fenton 1662 Fenton Business Park Court, Fenton, MO 63026 Call ~28.25 miles north of Desoto
  • 3-star Suburban property
  • Free breakfast
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From£59
Average 3.0 /5 Recent Reviews Call BookMore Details
Americas Best Value Inn St. Louis South 6602 South Lindbergh Blvd., St. Louis, MO 63123 Call ~28.28 miles northeast of Desoto
  • Two star Suburban property
  • Complimentary breakfast is offered
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From£36
Poor 2.0 /5 Guest Reviews Call BookMore Details
Best Western Plus Fenton - Fenton 1680 Fenton Business Park Court, Fenton, MO 63026 Call ~28.32 miles north of Desoto
  • Affordable Suburban property
  • Check-in: 03:00
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From£47
Average 3.0 /5 Reviews Call BookMore Details
Super 8 by Wyndham Fenton/St. Louis Area : 650 South Highway Dr. 650 South Highway Dr., Fenton, MO 63026 Call ~28.34 miles north of Desoto
  • Low priced property
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From£44
Poor 2.0 /5 Reviews Call BookMore Details
Aviator Hotel & Suites 6921 South Lindbergh Blvd., St Louis, MO 63125 Call ~28.36 miles northeast of Desoto
  • 3 star Suburban hotel
  • 6 suites in hotel
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From£59
Average 3.0 /5 Latest Reviews Call BookMore Details
Comfort Suites St. Louis 3654 South Lindbergh Blvd., St. Louis, MO 63127 Call ~29.13 miles north of Desoto
  • 2 star Suburban hotel
  • Check-in time: 2:00 pm
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From£36
Average 3.5 /5 Recent Reviews Call BookMore Details
Microtel Inn & Suites by Wyndham Sainte Genevieve 21958 State Highway 32, Ste. Genevieve, MO 63670 Call ~29.55 miles east of Desoto
  • 2 star Highway hotel
  • Check in time: 3:00 pm
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From£37
Average 3.0 /5 Read Reviews Call BookMore Details
Days Inn by Wyndham St. Louis Lindbergh Boulevard 3660 South Lindbergh Blvd., St Louis, MO 63127 Call ~29.61 miles north of Desoto
  • 3-star Suburban hotel
  • 116 rooms in property
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From£51
Average 3.0 /5 Reviews Call BookMore Details
Holiday Inn St. Louis Sw Route 66 An Ihg Hotel : 10709 Watson Rd. 10709 Watson Rd., St. Louis, MO 63127 Call ~29.78 miles north of Desoto
  • Affordable Suburban hotel
  • Gym is available on property
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From£58
Average 3.0 /5 Recent Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham - Saint Louis 1580 South Kirkwood Rd., Saint Louis, MO 63127 Call ~29.85 miles north of Desoto
  • 3-star Suburban property
  • Hotel has 3 floors
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From£74
Average 3.0 /5 Latest Reviews Call BookMore Details
Best Western St. Louis-Kirkwood Route 66 : 1200 South Kirkwood Rd. 1200 South Kirkwood Rd., Saint Louis, MO 63122 Call ~30.29 miles north of Desoto
  • Three Star Suburban hotel
  • Comp. Breakfast
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From£52
Very good 4.0 /5 Guest Reviews Call BookMore Details

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