Desoto Missouri Accommodations

Find hotels in Desoto using the list and search tools below. Search for the cheapest discounted hotel and motel rates in or near Desoto, MO for your corporate or personal leisure travel. We show the best Desoto Missouri hotel rooms. Review the Desoto hotel list below to find the perfect lodging. We also have a map of the Desoto hotels.

Desoto Hotels & Accommodations

Holiday Inn Club Vac Timber Creek in Desoto 4800 Us Highway 67, Desoto, MO 63020 Call
  • Mid-scale property
  • Fitness / Gym is on-site
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From£67
Very good 4.5 /5 Hotel Reviews Call BookMore Details
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IH 1802 Gamel Cemetery Rd., Festus, MO 63028 Call ~9.28 miles northeast of Desoto
  • Economy Highway property
  • Check in time: 3:00pm
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From£67
Very good 4.0 /5 Reviews Call BookMore Details
Comfort Inn Festus St. Louis South 1303 Veterans Blvd., Festus, MO 63028 Website Call ~9.48 miles northeast of Desoto
  • 3-star Suburban hotel
  • Check-in time: 3:00 PM
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From£33
Very good 4.0 /5 Guest Reviews Call BookMore Details
Baymont by Wyndham Festus 1200 West Gannon Dr., Festus, MO 63028 Call ~9.51 miles northeast of Desoto
  • Mid-scale Suburban property
  • 134 rooms in hotel
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From£53
Average 3.0 /5 Recent Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham Festus - St. Louis South 1001 Veterans Blvd., Festus, MO 63028 Call ~9.70 miles northeast of Desoto
  • 3-star Suburban hotel
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From£59
Average 3.0 /5 Recent Reviews Call BookMore Details
Super 8 by Wyndham Pevely - Pevely 1711 Highway Z, Pevely, MO 63070 Call ~13.03 miles northeast of Desoto
  • Economy property
  • Check-in: 11:00 AM
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From£26
Very good 4.0 /5 Latest Reviews Call BookMore Details
Super 8 by Wyndham Bonne Terre : 8 Northwood Dr. 8 Northwood Dr., Bonne Terre, MO 63628 Call ~14.93 miles south of Desoto
  • Low priced property
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From£44
Average 3.0 /5 Read Reviews Call BookMore Details
Motel 6 Bonne Terre Mo : 1017 Highway K 1017 Highway K, Bonne Terre, MO 63628 Call ~15.12 miles south of Desoto
  • Economy property
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From£44
Average 3.0 /5 Latest Reviews Call BookMore Details
Super 8 by Wyndham Potosi 820 East High St., Potosi, MO 63664 Call ~18.89 miles southwest of Desoto
  • Cheap Highway property
  • 3 suites in property
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From£36
Average 3.0 /5 Recent Reviews Call BookMore Details
Quality Inn & Suites 3610 West Outer Rd., Arnold, MO 63010 Call ~20.97 miles northeast of Desoto
  • Low-priced Suburban hotel
  • Hotel has 71 rooms
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From£44
Average 3.0 /5 Guest Reviews Call BookMore Details
Woodspring Suites St. Louis Arnold in Arnold 888 Arnold Commons Dr., Arnold, MO 63010 Call ~22.46 miles northeast of Desoto
  • Cheap Highway property
  • Hotel has 124 rooms
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From£23
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Drury Inn & Suites St. Louis Arnold 3800 State Rt 141, Arnold, MO 63010 Call ~22.57 miles northeast of Desoto
  • Three Star Suburban hotel
  • Free breakfast
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From£92
Excellent 5.0 /5 Review Score Call BookMore Details
Pear Tree Inn St. Louis Arnold 1201 Drury Lane, Arnold, MO 63010 Call ~23.16 miles northeast of Desoto
  • Midscale Suburban hotel
  • 4 floors in property
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From£59
Very good 4.0 /5 Reviews Call BookMore Details
Crown Pointe Lodge, BW Signature Collection : 4245 Hunt Rd. 4245 Hunt Rd., Farmington, MO 63640 Call ~23.27 miles south of Desoto
  • Mid-scale Golf Course property
  • 3 floors in hotel
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From£47
Very good 4.0 /5 Review Score Call BookMore Details
Best Western St. Louis Inn 6224 Heimos Industrial Park Dr., Saint Louis, MO 63129 Call ~24.42 miles northeast of Desoto
  • Low-priced Suburban hotel
  • 87 sleeping rooms in hotel
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From£30
Average 3.0 /5 Review Score Call BookMore Details
Hampton Inn Farmington - Farmington 850 Valley Creek Dr., Farmington, MO 63640 Call ~24.70 miles south of Desoto
  • Affordable Highway hotel
  • 3 floors in property
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From£59
Average 3.0 /5 Recent Reviews Call BookMore Details
Super 8 by Wyndham Farmington 930 Valley Creek Dr., Farmington, MO 63640 Call ~24.77 miles south of Desoto
  • Cheap property
  • Check-in: 3:00 pm
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From£36
Average 3.0 /5 Read Reviews Call BookMore Details
Holiday Inn Express & Suites Farmington by IHG in Farmington 820 Market St., Farmington, MO 63640 Call ~24.80 miles south of Desoto
  • Mid-scale Rural hotel
  • 3 floors in hotel
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From£74
Very good 4.0 /5 Review Score Call BookMore Details
680 Fenton Business Park Ct Fenton Missouri 63026 Fenton Business Park Court Fenton, Fenton, IA 63026 Call ~25.48 miles north of Desoto
  • Affordable property
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From£59
Average 3.0 /5 Reviews Call BookMore Details
Quality Inn Farmington in Farmington 1400 West Liberty St., Farmington, MO 63640 Call ~25.62 miles south of Desoto
  • 3 star Rural hotel
  • Hotel has 48 rooms
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From£59
Average 3.0 /5 Guest Reviews Call BookMore Details
America's Best Inn Eureka 1725 West 5th St., Eureka, MO 63025 Call ~25.87 miles north of Desoto
  • Two-star Highway property
  • Check in: 11.00am
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From£44
Poor 2.0 /5 Hotel Reviews Call BookMore Details
Super 8 by Wyndham Eureka/Six Flags Nearby 1733 West 5th St., Eureka, MO 63025 Call ~25.94 miles north of Desoto
  • Two star Highway property
  • Check-in time: ex. 3:00 PM
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From£44
Average 3.0 /5 Read Reviews Call BookMore Details
Baymont Inn and Suites by Wyndham Farmington, MO in Farmington 1625 West Columbia St., Farmington, MO 63640 Call ~25.97 miles south of Desoto
  • Affordable Highway hotel
  • Free comp. breakfast
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From£59
Average 3.0 /5 Reviews Call BookMore Details
Fairfield Inn N Ste St. Louis South 4318 Butler Hill Rd., St Louis, MO 63128 Call ~26.09 miles northeast of Desoto
  • 3-star property
  • Check-in: 15:00
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From£67
Average 3.0 /5 Recent Reviews Call BookMore Details
Holiday Inn Express & Suites St. Louis South I 55 by IHG 4250 Midamerica Ln, St. Louis, MO 63129 Call ~26.13 miles northeast of Desoto
  • Midscale Suburban property
  • Check-in: 3p
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From£59
Average 3.0 /5 Latest Reviews Call BookMore Details
Quality Inn Near Six Flags St. Louis : 1400 West Osage St. 1400 West Osage St., Pacific, MO 63069 Call ~26.17 miles northwest of Desoto
  • Three Star Rural hotel
  • 46 rooms in hotel
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From£59
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Hampton Inn & Suites St. Louis/South I-55 - St. Louis 4200 Midamerica Ln, St. Louis, MO 63129 Call ~26.18 miles northeast of Desoto
  • Midscale Suburban property
  • Gym / Fitness Center Available
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From£59
Very good 4.0 /5 Guest Reviews Call BookMore Details
Comfort Inn Near Six Flags St. Louis 1320 Thornton St., Pacific, MO 63069 Call ~26.28 miles northwest of Desoto
  • 3 star Highway hotel
  • Fitness center on property
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From£65
Average 3.0 /5 Review Score Call BookMore Details
Holiday Inn St. Louis West Six Flags by IHG : 4901 Six Flags Rd. 4901 Six Flags Rd., Eureka, MO 63025 Call ~26.41 miles north of Desoto
  • Three Star Suburban property
  • 3 floors in property
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From£96
Average 3.0 /5 Read Reviews Call BookMore Details
Super 8 by Wyndham Waterloo 112 Warren Dr., Waterloo, IL 62298 Call ~26.68 miles northeast of Desoto
  • Economical Rural hotel
  • Check in time: 3:00 PM
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From£44
Average 3.5 /5 Review Score Call BookMore Details
Super 8 by Wyndham St. Clair MO in Saint Clair 1010 South Outer Rd., Saint Clair, MO 63077 Call ~27.53 miles northwest of Desoto
  • Economical Highway hotel
  • 3 floors in hotel
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From£44
Average 3.0 /5 Reviews Call BookMore Details
Pinemark Inn & Suites - St. Clair 866 South Outer Rd., St. Clair, MO 63077 Call ~27.60 miles northwest of Desoto
  • 2 star Highway hotel
  • Check-in: 3:00 PM
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From£45
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Hampton Inn St. Louis Southwest : 9 Lambert Drury Place 9 Lambert Drury Place, St. Louis, MO 63088 Call ~27.66 miles north of Desoto
  • Midscale Suburban property
  • Fitness center on property
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From£63
Very good 4.5 /5 Latest Reviews Call BookMore Details
Drury Inn & Suites St. Louis Southwest : 5 Lambert Drury Place (I 44 & 141) 5 Lambert Drury Place (I 44 & 141), St. Louis, MO 63088 Call ~27.66 miles north of Desoto
  • 3 star Suburban property
  • Hotel has 7 floors
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From£62
Very good 4.5 /5 Reviews Call BookMore Details
Hampton Inn St. Louis Columbia 165 Admiral Trost Dr., Columbia, IL 62236 Call ~27.76 miles northeast of Desoto
  • Affordable Suburban property
  • 2 meeting rooms in hotel
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From£59
Average 3.0 /5 Review Score Call BookMore Details
Holiday Inn Express & Suites St. Louis West - Fenton by IHG : 1848 Bowles Ave. 1848 Bowles Ave., Fenton, MO 63026 Call ~27.97 miles north of Desoto
  • 3-star Suburban property
  • Comp. Breakfast
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From£59
Very good 4.0 /5 Recent Reviews Call BookMore Details
Motel 6 Fenton Mo : 1860 Bowles Ave. 1860 Bowles Ave., Fenton, MO 63026 Call ~27.99 miles north of Desoto
  • Inexpensive hotel
  • Hotel has 58 rooms
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From£44
Average 3.0 /5 Guest Reviews Call BookMore Details
Wingate by Wyndham St. Louis / Fenton Route 66 1100 South Highway Dr., Fenton, MO 63026 Call ~28.11 miles north of Desoto
  • Midscale Suburban hotel
  • Free breakfast available
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From£59
Average 3.0 /5 Reviews Call BookMore Details
Heritage Inn & Suites St. Louis / Fenton Trademark by Wyndham in Fenton 1088 South Highway Dr., Fenton, MO 63026 Call ~28.17 miles north of Desoto
  • 3-star Suburban hotel
  • Hotel has 11 suites
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From£59
Average 3.0 /5 Reviews Call BookMore Details
Extended Stay America Suites St. Louis Fenton - Fenton 1662 Fenton Business Park Court, Fenton, MO 63026 Call ~28.25 miles north of Desoto
  • Affordable Suburban hotel
  • Check-in time: 3:00 pm
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From£59
Average 3.0 /5 Latest Reviews Call BookMore Details
Americas Best Value Inn St. Louis South - St. Louis 6602 South Lindbergh Blvd., St. Louis, MO 63123 Call ~28.28 miles northeast of Desoto
  • Low-priced Suburban hotel
  • 3 floors in property
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From£36
Poor 2.0 /5 Read Reviews Call BookMore Details
Best Western Plus Fenton in Fenton 1680 Fenton Business Park Court, Fenton, MO 63026 Call ~28.32 miles north of Desoto
  • Mid-scale Suburban property
  • Free comp. breakfast
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From£47
Average 3.0 /5 Review Score Call BookMore Details
Super 8 by Wyndham Fenton/St. Louis Area 650 South Highway Dr., Fenton, MO 63026 Call ~28.34 miles north of Desoto
  • 2 star hotel
  • Check-in time: 15:00
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From£44
Poor 2.0 /5 Review Score Call BookMore Details
Aviator Hotel & Suites in St Louis 6921 South Lindbergh Blvd., St Louis, MO 63125 Call ~28.36 miles northeast of Desoto
  • 3 star Suburban property
  • 149 rooms in property
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From£59
Average 3.0 /5 Guest Reviews Call BookMore Details
Comfort Suites St. Louis 3654 South Lindbergh Blvd., St. Louis, MO 63127 Call ~29.13 miles north of Desoto
  • Cheap Suburban property
  • 24 suites in hotel
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From£36
Average 3.5 /5 Read Reviews Call BookMore Details
Microtel Inn & Suites by Wyndham Sainte Genevieve 21958 State Highway 32, Ste. Genevieve, MO 63670 Call ~29.55 miles east of Desoto
  • Inexpensive Highway property
  • Hotel has 6 suites
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From£37
Average 3.0 /5 Recent Reviews Call BookMore Details
Days Inn by Wyndham St. Louis Lindbergh Boulevard in St Louis 3660 South Lindbergh Blvd., St Louis, MO 63127 Call ~29.61 miles north of Desoto
  • 3-star Suburban property
  • 60 suites in hotel
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From£51
Average 3.0 /5 Reviews Call BookMore Details
Holiday Inn St. Louis Sw Route 66 An Ihg Hotel - St. Louis 10709 Watson Rd., St. Louis, MO 63127 Call ~29.78 miles north of Desoto
  • 3-star Suburban hotel
  • 4 floors in hotel
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From£59
Average 3.0 /5 Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham 1580 South Kirkwood Rd., Saint Louis, MO 63127 Call ~29.85 miles north of Desoto
  • Three Star Suburban hotel
  • Hotel has 3 floors
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From£74
Average 3.0 /5 Reviews Call BookMore Details
Best Western St. Louis-Kirkwood Route 66 in Saint Louis 1200 South Kirkwood Rd., Saint Louis, MO 63122 Call ~30.29 miles north of Desoto
  • Midscale Suburban property
  • Hotel has 113 rooms
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From£52
Very good 4.0 /5 Hotel Reviews Call BookMore Details

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