Cairo Illinois Accommodations

Find hotels & motels in Cairo using the list below. Search for cheap and discounted hotel and motel rates in or close to Cairo, IL for your upcoming individual or group travel. Discover the best Cairo Illinois hotel/motel rooms. Review the Cairo hotel list below to find the perfect lodging. We also have a map of the Cairo hotels.

Cairo Hotels, Motels & Accommodations

Quality Inn Cairo I-57
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
13201 Kessler Rd., Cairo, IL 62914 +1-888-389-4121
  • Affordable Highway hotel
  • Check in: 3 pm
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From$60
Poor 2.0 /5 Guest Reviews Call BookMore Details
Super 8 by Wyndham Charleston/Sikeston East MO - Charleston
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
310 South Story, Charleston, MO 63834 +1-888-675-2083 ~10.13 miles southwest of Cairo
  • Inexpensive Highway hotel
  • Comp. Breakfast
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From$42
Average 3.5 /5 Review Score Call BookMore Details
The Riverstone Hotel Charleston-Sikeston
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
102 Drake St., Charleston, MO 63834 +1-800-716-8490 ~11.88 miles southwest of Cairo
  • Low Cost Highway property
  • 9 suites in property
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From$59
Average 3.0 /5 Review Score Call BookMore Details
Americas Best Value Inn Ullin Mounds - Ullin
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
128 Cheekwood Lane, Ullin, IL 62992 +1-800-805-5223 ~17.88 miles north of Cairo
  • 2-star hotel
  • Comp. Breakfast
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From$60
Average 3.0 /5 Hotel Reviews Call BookMore Details
Motel 6 Sikeston Mo : 110 South Interstate Dr.
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
110 South Interstate Dr., SIKESTON, MO 63801 +1-888-965-1860 ~20.96 miles west of Cairo
  • Low priced hotel
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From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
Best Western Plus Sikeston
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
120 South Interstate Dr., Sikeston, MO 63801 +1-888-788-5576 ~21.00 miles west of Cairo
  • Low priced Highway property
  • Hotel has an eco-friendly policy See policy
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From$42
Very Good 4.0 /5 Review Score Call BookMore Details
Days Inn and Suites by Wyndham Sikeston : 220 South Interstate Dr.
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
220 South Interstate Dr., Sikeston, MO 63801 +1-888-897-9207 ~21.07 miles west of Cairo
  • Economical property
  • Check-in: 03:00 PM
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From$60
Average 3.0 /5 Review Score Call BookMore Details
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
100 Matthews Lane, Sikeston, MO 63801 +1-888-311-4278 ~21.31 miles west of Cairo
  • 3 star Highway hotel
  • Free breakfast available
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From$80
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Super 8 by Wyndham Sikeston/Miner Area
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
2609 East Malone, Sikeston, MO 63801 +1-888-469-4795 ~21.32 miles west of Cairo
  • Low Cost Convention Center hotel
  • Free breakfast available
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From$60
Average 3.0 /5 Hotel Reviews Call BookMore Details
Comfort Inn : 109 Matthews Lane
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
109 Matthews Lane, Sikeston, MO 63801 +1-888-734-9421 ~21.34 miles west of Cairo
  • Midscale Highway hotel
  • 64 rooms in hotel
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From$85
Average 3.0 /5 Review Score Call BookMore Details
Hampton Inn Sikeston in Sikeston
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
1240 Commerce Dr., Sikeston, MO 63801 +1-888-841-5292 ~24.48 miles west of Cairo
  • Midscale Rural property
  • Check in: 3:00 PM
More Photos
From$80
Average 3.0 /5 Review Score Call BookMore Details
Holiday Inn Express & Suites Sikeston An Ihg Hotel in Sikeston
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
115 Hospitality Dr., Sikeston, MO 63801 +1-888-455-5160 ~24.49 miles west of Cairo
  • 3-star Rural property
  • 73 rooms in hotel
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From$80
Average 3.0 /5 Recent Reviews Call BookMore Details
Residence Inn by Marriott Paducah - Paducah
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
3900 Coleman Crossing Circle, Paducah, KY 42001 +1-888-965-8297 ~25.66 miles east of Cairo
  • Three Star Suburban hotel
  • 74 suites in property
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From$89
Very Good 4.0 /5 Reviews Call BookMore Details
Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destinatio : 100 East Front St.
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
100 East Front St., Metropolis, IL 62960 +1-888-906-6358 ~26.28 miles east of Cairo
  • Four star hotel
  • 7 floors in hotel
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From$160
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Baymont by Wyndham Metropolis : 203 East Front St.
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
203 East Front St., Metropolis, IL 62960 +1-888-749-6785 ~26.32 miles east of Cairo
  • 2 star Riverfront property
  • Free breakfast
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From$45
Average 3.0 /5 Hotel Reviews Call BookMore Details
Econo Lodge
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
1415 East 5th St., Metropolis, IL 62960 +1-888-878-9982 ~27.38 miles east of Cairo
  • Two star property
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From$60
Not Good 1.0 /5 Guest Reviews Call BookMore Details
 Econo Lodge Paducah West I-24 : 5120 Hinkleville Rd.
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
5120 Hinkleville Rd., Paducah, KY 42001 +1-888-389-4485 ~27.55 miles east of Cairo
  • Low-priced Airport property
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From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
Baymont by Wyndham Paducah in Paducah
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
5300 Old Cairo Rd., Paducah, KY 42001 +1-888-389-4121 ~27.64 miles east of Cairo
  • Three Star hotel
  • 3 floors in hotel
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From$40
Poor 2.0 /5 Review Score Call BookMore Details
Courtyard by Marriott Cape Girardeau Downtown
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
400 Broadway St., Cape Girardeau, MO 63701 +1-888-675-2083 ~27.65 miles northwest of Cairo
  • 3 star Downtown hotel
  • 78 rooms in property
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From$80
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Quality Suites Paducah I-24
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
2880 James Sanders Blvd., Paducah, KY 42001 Website +1-800-716-8490 ~27.73 miles east of Cairo
  • Cheap Highway hotel
  • 2 floors in property
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From$60
Average 3.0 /5 Hotel Reviews Call BookMore Details
Comfort Inn & Suites near Six Flags in Lithia Springs
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
960 West Pointe Court, Lithia Springs, GA 30122 Website +1-800-805-5223 ~27.80 miles east of Cairo
  • Affordable Downtown hotel
  • Fitness center on property
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From$70
Very Good 4.0 /5 Reviews Call BookMore Details
Garner Hotel Paducah West by IHG - Paducah
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
145 Mcbride Lane, Paducah, KY 42001 +1-888-965-1860 ~27.80 miles east of Cairo
  • Midscale Highway hotel
  • Check in time: 3pm
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From$49
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Hotel 7 Inn Paducah : 5001 Hinkleville Rd.
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
5001 Hinkleville Rd., Paducah, KY 42001 +1-888-788-5576 ~27.81 miles east of Cairo
  • Cheap hotel
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From$60
Average 3.0 /5 Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham Paducah
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
3960 Coleman Crossing Cir, Paducah, KY 42001 +1-888-897-9207 ~27.90 miles east of Cairo
  • Affordable Highway property
  • Free complimentary breakfast
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From$80
Average 3.0 /5 Read Reviews Call BookMore Details
Candlewood Suites Paducah by IHG
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
3940 Coleman Crossing Circle, Paducah, KY 42001 +1-888-311-4278 ~27.91 miles east of Cairo
  • Mid-scale Rural property
  • 85 suites in property
More Photos
From$60
Very Good 4.0 /5 Reviews Call BookMore Details
Homewood Suites by Hilton Paducah in Paducah
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
3925 Coleman Crossing Cir, Paducah, KY 42001 +1-888-469-4795 ~27.94 miles east of Cairo
  • Affordable Highway hotel
  • Gym is available on property
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From$109
Very Good 4.0 /5 Reviews Call BookMore Details
Comfort Suites
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
3918 Coleman Crossing Cir Paducah Ky 42001, Paducah, KY 42001 +1-888-734-9421 ~27.96 miles east of Cairo
  • 2 star Rural hotel
  • Comp. Breakfast
More Photos
From$60
Average 3.0 /5 Hotel Reviews Call BookMore Details
Comfort Inn Paducah in Paducah
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
5135 Cairo Rd., Paducah, KY 42001 +1-888-841-5292 ~27.98 miles east of Cairo
  • 3-star property
  • Hotel has 3 floors
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From$59
Very Good 4.0 /5 Review Score Call BookMore Details
Fairfield Inn & Suites by Marriott Paducah
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
3950 Coleman Crossing Circle, Paducah, KY 42001 +1-888-455-5160 ~28.01 miles east of Cairo
  • Mid-scale Rural property
  • 2 meeting rooms in hotel
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From$75
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Red Roof Inn Paducah in Paducah
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
5106 Old Cairo Rd., Paducah, KY 42001 +1-888-965-8297 ~28.01 miles east of Cairo
  • Two-star hotel
  • Check-in: 14:00
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From$45
Average 3.5 /5 Guest Reviews Call BookMore Details
American Inn
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
5125 Cairo Rd., Paducah, KY 42001 +1-888-906-6358 ~28.02 miles east of Cairo
  • Two-star hotel
  • Free complimentary breakfast
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From$37
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Hampton Inn & Suites Paducah : 3901 Coleman Crossing Circle
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
3901 Coleman Crossing Circle, Paducah, KY 42001 +1-888-749-6785 ~28.02 miles east of Cairo
  • Three Star Highway property
  • Access to gym on-site
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From$79
Very Good 4.5 /5 Guest Reviews Call BookMore Details
Holiday Inn Express Hotel & Suites Paducah West by IHG : 3996 Hinkleville Rd.
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
3996 Hinkleville Rd., Paducah, KY 42001 +1-888-878-9982 ~28.04 miles east of Cairo
  • Mid-scale Highway property
  • Hotel has 3 floors
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From$80
Average 3.0 /5 Recent Reviews Call BookMore Details
Spark by Hilton Paducah - Paducah
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
3994 Hinkleville Rd., Paducah, KY 42001 +1-888-389-4485 ~28.05 miles east of Cairo
  • 3-star Airport hotel
  • Check in: 3:00 PM
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From$80
Very Good 4.0 /5 Review Score Call BookMore Details
Courtyard by Marriott Paducah in Paducah
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
3835 Technology Dr., Paducah, KY 42001 +1-888-389-4121 ~28.29 miles east of Cairo
  • 3 star Suburban hotel
  • Hotel has 3 floors
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From$89
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Days Inn by Wyndham Paducah I-24 Exit 4 in Paducah
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
3901 Hinkleville Rd., Paducah, KY 42001 +1-888-675-2083 ~28.75 miles east of Cairo
  • Inexpensive Highway hotel
  • 2 floors in property
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From$50
Average 3.0 /5 Recent Reviews Call BookMore Details
Candlewood Suites Cape Girardeau by IHG
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
485 South Mount Auburn Rd., Cape Girardeau, MO 65703 +1-800-716-8490 ~28.76 miles northwest of Cairo
  • Low-priced Highway property
  • 4 floors in property
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From$69
Very Good 4.0 /5 Reviews Call BookMore Details
Travelers Inn and Suites - Paducah
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
2550 Lone Oak Rd., Paducah, KY 42003 +1-800-805-5223 ~28.88 miles east of Cairo
  • Low priced property
  • Hotel has 33 rooms
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From$38
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Quality Inn & Suites Metropolis I-24 - Metropolis
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
2118 East 5th St., Metropolis, IL 62960 +1-888-965-1860 ~28.88 miles east of Cairo
  • 3 star property
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From$80
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Super 8 by Wyndham Metropolis
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
2055 East 5th St., Metropolis, IL 62960 +1-888-788-5576 ~28.89 miles east of Cairo
  • Two star Highway property
  • 2 floors in property
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From$60
Average 3.0 /5 Reviews Call BookMore Details
Motel 6 Metropolis Il : 2119 East 5th St.
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
2119 East 5th St., Metropolis, IL 62960 +1-888-897-9207 ~29.04 miles east of Cairo
  • Two-star property
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From$60
Average 3.0 /5 Recent Reviews Call BookMore Details
Holiday Inn Express Metropolis by IHG : 2179 East 5th St.
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
2179 East 5th St., Metropolis, IL 62960 +1-888-311-4278 ~29.10 miles east of Cairo
  • Three Star Rural hotel
  • Hotel has an eco-friendly policy See policy
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From$65
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Hampton Inn Cape Girardeau I 55 East : 207 South Mount Auburn Rd.
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
207 South Mount Auburn Rd., Cape Girardeau, MO 63703 +1-888-469-4795 ~29.41 miles northwest of Cairo
  • Midscale Highway property
  • 4 floors in property
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From$80
Excellent 5.0 /5 Recent Reviews Call BookMore Details
Victorian Inn & Suites in Cape Girardeau
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
3256 William St., Cape Girardeau, MO 63703 +1-888-734-9421 ~29.41 miles northwest of Cairo
  • 3-star Golf Course hotel
  • 133 sleeping rooms in hotel
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From$79
Average 3.0 /5 Review Score Call BookMore Details
Auburn Place Hotel & Suites - Cape Girardeau
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
3265 Williams St., Cape Girardeau, MO 63702 +1-888-841-5292 ~29.42 miles northwest of Cairo
  • Mid-scale Highway hotel
  • Fitness center on property
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From$58
Very Good 4.5 /5 Recent Reviews Call BookMore Details
Holiday Inn Express & Suites Cape Girardeau I 55 by Ihg
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
3253 William St., Cape Girardeau, MO 63701 +1-888-455-5160 ~29.49 miles northwest of Cairo
  • Midscale hotel
  • Check in time: 3:00 pm
More Photos
From$80
Very Good 4.5 /5 Read Reviews Call BookMore Details
Fairfield Inn & Suites Cape Girardeau in Cape Girardeay
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
433 Cape West Crossing, Cape Girardeay, MO 63703 +1-888-965-8297 ~29.58 miles northwest of Cairo
  • Midscale property
  • Access to gym on-site
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From$80
Average 3.0 /5 Hotel Reviews Call BookMore Details
Drury Lodge - Cape Girardeau
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
104 South Vantage Dr., Cape Girardeau, MO 63701 +1-888-906-6358 ~29.82 miles northwest of Cairo
  • 3 star Highway hotel
  • Free breakfast
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From$80
Average 3.0 /5 Read Reviews Call BookMore Details
Quality Inn Cape Girardeau North - Cape Girardeau
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
2011 North Kingshighway St., Cape Girardeau, MO 63701 Website +1-888-749-6785 ~31.37 miles northwest of Cairo
  • Economical hotel
  • Complimentary breakfast is offered
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From$60
Very Good 4.0 /5 Read Reviews Call BookMore Details
Hotel 7 Inn Anna
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
100 Richview Dr., Anna, IL 62906 +1-888-878-9982 ~31.39 miles north of Cairo
  • Low-priced hotel
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From$60
Very Good 4.0 /5 Reviews Call BookMore Details

Next: See My Cairo Hotels with Pricing

Verified reviews of the city: Cairo, IL

Below are reviews of the city of Cairo, IL from an actual visitor's perspective.

"Spending time with my family"
Score 5.0 / 5

Vincent R., from 26-Jan-2026
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Table of Contents Top: Check Rates Cairo Hotels