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Cairo Illinois Accommodations

Find hotels & motels in Cairo using the list below. Search for cheap and discounted hotel and motel rates in or close to Cairo, IL for your upcoming individual or group travel. Discover the best Cairo Illinois hotel/motel rooms. Review the Cairo hotel list below to find the perfect lodging. We also have a map of the Cairo hotels.

Cairo Hotels/Motels & Accommodations

Quality Inn Cairo I-57 13201 Kessler Rd., Cairo, IL 62914
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  • Midscale Highway property
  • 38 rooms in hotel
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From$60
Poor 2.0 /5 Hotel Reviews Call BookMore Details
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Super 8 by Wyndham Charleston/Sikeston East MO 310 South Story, Charleston, MO 63834
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~10.13 miles southwest of Cairo
  • Low priced Highway property
  • Check in: 3:00pm
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From$42
Average 3.5 /5 Recent Reviews Call BookMore Details
The Riverstone Hotel Charleston-Sikeston - Charleston 102 Drake St., Charleston, MO 63834
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~11.88 miles southwest of Cairo
  • Economy Highway hotel
  • Check in time: 3:00PM
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From$59
Average 3.0 /5 Latest Reviews Call BookMore Details
Americas Best Value Inn Ullin Mounds in Ullin 128 Cheekwood Lane, Ullin, IL 62992
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~17.88 miles north of Cairo
  • 2 star property
  • Hotel has 40 rooms
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From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
Motel 6 Sikeston Mo 110 South Interstate Dr., SIKESTON, MO 63801
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~20.96 miles west of Cairo
  • Inexpensive property
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From$60
Average 3.0 /5 Recent Reviews Call BookMore Details
Best Western Plus Sikeston I-55 in Sikeston 120 South Interstate Dr., Sikeston, MO 63801
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~21.00 miles west of Cairo
  • 2 star Highway hotel
  • Check in time: 03:00
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From$42
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Days Inn & Suites by Wyndham Sikeston : 220 South Interstate Dr. 220 South Interstate Dr., Sikeston, MO 63801
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~21.07 miles west of Cairo
  • Two-star property
  • Check in: 03:00 PM
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From$60
Average 3.0 /5 Hotel Reviews Call BookMore Details
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) in Sikeston 100 Matthews Lane, Sikeston, MO 63801
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~21.31 miles west of Cairo
  • Midscale Highway property
  • Hotel has 40 rooms
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From$80
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Super 8 by Wyndham Sikeston/Miner Area - Sikeston 2609 East Malone, Sikeston, MO 63801
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~21.32 miles west of Cairo
  • Inexpensive Convention Center property
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From$60
Average 3.0 /5 Read Reviews Call BookMore Details
Comfort Inn - Sikeston 109 Matthews Lane, Sikeston, MO 63801
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~21.34 miles west of Cairo
  • 3-star Highway hotel
  • Gym is available on property
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From$85
Average 3.0 /5 Recent Reviews Call BookMore Details
Hampton Inn Sikeston in Sikeston 1240 Commerce Dr., Sikeston, MO 63801
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~24.48 miles west of Cairo
  • 3-star Rural property
  • Free complimentary breakfast
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From$80
Average 3.0 /5 Latest Reviews Call BookMore Details
Holiday Inn Express & Suites Sikeston An Ihg Hotel : 115 Hospitality Dr. 115 Hospitality Dr., Sikeston, MO 63801
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~24.49 miles west of Cairo
  • Three Star Rural hotel
  • Check in: 3:00pm
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From$80
Average 3.0 /5 Review Score Call BookMore Details
Residence Inn by Marriott Paducah in Paducah 3900 Coleman Crossing Circle, Paducah, KY 42001
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~25.66 miles east of Cairo
  • Three Star Suburban hotel
  • 74 rooms in hotel
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From$89
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
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Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destinatio : 100 East Front St. 100 East Front St., Metropolis, IL 62960
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~26.28 miles east of Cairo
  • Four star hotel
  • Hotel has 12 suites
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From$160
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Baymont by Wyndham Metropolis - Metropolis 203 East Front St., Metropolis, IL 62960
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~26.32 miles east of Cairo
  • Low Cost Riverfront property
  • Free comp. breakfast
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From$45
Average 3.0 /5 Read Reviews Call BookMore Details
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Econo Lodge - Metropolis 1415 East 5th St., Metropolis, IL 62960
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~27.38 miles east of Cairo
  • Cheap property
  • Check in: 11:00
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From$60
Not Good 1.0 /5 Latest Reviews Call BookMore Details
 Econo Lodge Paducah West I-24 5120 Hinkleville Rd., Paducah, KY 42001
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~27.55 miles east of Cairo
  • Two-star Airport property
  • Check-in time: 15:00pm
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From$60
Average 3.0 /5 Hotel Reviews Call BookMore Details
Baymont by Wyndham Paducah in Paducah 5300 Old Cairo Rd., Paducah, KY 42001
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~27.64 miles east of Cairo
  • 3-star hotel
  • Check in time: 15:00
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From$40
Poor 2.0 /5 Guest Reviews Call BookMore Details
Courtyard by Marriott Cape Girardeau Downtown : 400 Broadway St. 400 Broadway St., Cape Girardeau, MO 63701
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~27.65 miles northwest of Cairo
  • Midscale Downtown hotel
  • 5 floors in hotel
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From$80
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Drury Suites Paducah in Paducah 2930 James Sanders Blvd., Paducah, KY 42001
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~27.70 miles east of Cairo
  • 3-star Suburban hotel
  • Hotel has an eco-friendly policy See policy
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From$99
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Quality Suites Paducah I-24 2880 James Sanders Blvd., Paducah, KY 42001 Website
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~27.73 miles east of Cairo
  • Two-star Highway hotel
  • 2 floors in hotel
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From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
Comfort Inn & Suites near Six Flags 960 West Pointe Court, Lithia Springs, GA 30122 Website
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~27.80 miles east of Cairo
  • 3 star Downtown hotel
  • 2 floors in property
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From$70
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Garner Hotel Paducah West by IHG in Paducah 145 Mcbride Lane, Paducah, KY 42001
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~27.80 miles east of Cairo
  • Three Star Highway property
  • 3 floors in property
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From$49
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Hotel 7 Inn Paducah 5001 Hinkleville Rd., Paducah, KY 42001
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~27.81 miles east of Cairo
  • Economy hotel
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From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham Paducah - Paducah 3960 Coleman Crossing Cir, Paducah, KY 42001
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~27.90 miles east of Cairo
  • 3-star Highway hotel
  • Free breakfast
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From$80
Average 3.0 /5 Guest Reviews Call BookMore Details
Candlewood Suites Paducah by IHG - Paducah 3940 Coleman Crossing Circle, Paducah, KY 42001
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~27.91 miles east of Cairo
  • 3 star Rural property
  • Hotel has 85 rooms
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From$60
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Homewood Suites by Hilton Paducah - Paducah 3925 Coleman Crossing Cir, Paducah, KY 42001
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~27.94 miles east of Cairo
  • 3-star Highway hotel
  • 97 suites in property
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From$109
Very Good 4.0 /5 Reviews Call BookMore Details
Comfort Suites : 3918 Coleman Crossing Cir Paducah Ky 42001 3918 Coleman Crossing Cir Paducah Ky 42001, Paducah, KY 42001
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~27.96 miles east of Cairo
  • Two star Rural property
  • Check in: 3:00pm
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From$60
Average 3.0 /5 Recent Reviews Call BookMore Details
Comfort Inn Paducah 5135 Cairo Rd., Paducah, KY 42001
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~27.98 miles east of Cairo
  • 3 star hotel
  • 66 sleeping rooms in hotel
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From$59
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Fairfield Inn & Suites by Marriott Paducah 3950 Coleman Crossing Circle, Paducah, KY 42001
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~28.01 miles east of Cairo
  • 3-star Rural hotel
  • Fitness center on property
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From$75
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Red Roof Inn Paducah : 5106 Old Cairo Rd. 5106 Old Cairo Rd., Paducah, KY 42001
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~28.01 miles east of Cairo
  • Low priced hotel
  • Hotel has 3 floors
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From$45
Average 3.5 /5 Review Score Call BookMore Details
American Inn in Paducah 5125 Cairo Rd., Paducah, KY 42001
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~28.02 miles east of Cairo
  • 2 star property
  • Check-in: 14:00
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From$37
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Hampton Inn & Suites Paducah in Paducah 3901 Coleman Crossing Circle, Paducah, KY 42001
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~28.02 miles east of Cairo
  • Affordable Highway property
  • 4 floors in hotel
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From$79
Very Good 4.5 /5 Latest Reviews Call BookMore Details
Holiday Inn Express Hotel & Suites Paducah West by IHG : 3996 Hinkleville Rd. 3996 Hinkleville Rd., Paducah, KY 42001
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~28.04 miles east of Cairo
  • 3-star Highway hotel
  • Comp. Breakfast
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From$80
Average 3.0 /5 Read Reviews Call BookMore Details
Auburn Place Hotel & Suites - Paducah 3994 Hinkleville Rd., Paducah, KY 42001
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~28.05 miles east of Cairo
  • Affordable Airport property
  • 3 floors in hotel
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From$80
Very Good 4.0 /5 Reviews Call BookMore Details
Courtyard by Marriott Paducah in Paducah 3835 Technology Dr., Paducah, KY 42001
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~28.29 miles east of Cairo
  • 3 star Suburban property
  • Fitness + Health Center
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From$89
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Days Inn by Wyndham Paducah I-24 Exit 4 3901 Hinkleville Rd., Paducah, KY 42001
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~28.75 miles east of Cairo
  • Cheap Highway property
  • 122 rooms in property
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From$50
Average 3.0 /5 Review Score Call BookMore Details
Candlewood Suites Cape Girardeau by IHG 485 South Mount Auburn Rd., Cape Girardeau, MO 65703
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~28.76 miles northwest of Cairo
  • 2-star Highway hotel
  • Hotel has 85 rooms
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From$69
Very Good 4.0 /5 Read Reviews Call BookMore Details
Travelers Inn and Suites 2550 Lone Oak Rd., Paducah, KY 42003
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~28.88 miles east of Cairo
  • Inexpensive hotel
  • 2 floors in hotel
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From$38
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Quality Inn & Suites Metropolis I-24 2118 East 5th St., Metropolis, IL 62960
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~28.88 miles east of Cairo
  • Three Star hotel
  • Check in time: 11:00
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From$80
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Super 8 by Wyndham Metropolis : 2055 East 5th St. 2055 East 5th St., Metropolis, IL 62960
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~28.89 miles east of Cairo
  • Low-priced Highway property
  • Check in time: 02:00PM
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From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
Motel 6 Metropolis Il in Metropolis 2119 East 5th St., Metropolis, IL 62960
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~29.04 miles east of Cairo
  • Low Cost property
  • Check-in time: 11:00 AM
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From$60
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Holiday Inn Express Metropolis by IHG 2179 East 5th St., Metropolis, IL 62960
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~29.10 miles east of Cairo
  • 3 star Rural property
  • Hotel has an eco-friendly policy Read more
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From$65
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Hampton Inn Cape Girardeau I 55 East - Cape Girardeau 207 South Mount Auburn Rd., Cape Girardeau, MO 63703
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~29.41 miles northwest of Cairo
  • Three Star Highway property
  • Check-in: 3:00 pm
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From$80
Excellent 5.0 /5 Guest Reviews Call BookMore Details
Victorian Inn & Suites 3256 William St., Cape Girardeau, MO 63703
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~29.41 miles northwest of Cairo
  • Midscale Golf Course property
  • 133 rooms in hotel
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From$79
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Auburn Place Hotel & Suites 3265 Williams St., Cape Girardeau, MO 63702
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~29.42 miles northwest of Cairo
  • 3-star Highway hotel
  • 2 floors in property
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From$58
Very Good 4.5 /5 Reviews Call BookMore Details
Holiday Inn Express & Suites Cape Girardeau I 55 by Ihg : 3253 William St. 3253 William St., Cape Girardeau, MO 63701
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~29.49 miles northwest of Cairo
  • Three Star hotel
  • Gym / Fitness Center Available
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From$80
Very Good 4.5 /5 Reviews Call BookMore Details
Fairfield Inn & Suites Cape Girardeau 433 Cape West Crossing, Cape Girardeay, MO 63703
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~29.58 miles northwest of Cairo
  • 3-star hotel
  • 4 floors in hotel
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From$80
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Drury Suites Cape Girardeau 3303 Campster Dr., Cape Girardeau, MO 63701
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~29.72 miles northwest of Cairo
  • 3 star Highway hotel
  • 5 floors in property
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From$85
Very Good 4.5 /5 Latest Reviews Call BookMore Details
Drury Lodge : 104 South Vantage Dr. 104 South Vantage Dr., Cape Girardeau, MO 63701
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~29.82 miles northwest of Cairo
  • Three Star Highway property
  • Fitness + Health Center
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From$80
Average 3.0 /5 Read Reviews Call BookMore Details

Next: See My Cairo Hotels with Pricing

Graph: Upcoming 20 Days of Cairo Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Cairo, IL discounts available. The chart reflects the cheapest Cairo hotel for each day and each star rating category.

FAQs about hotels in Cairo

What are the most favored hotels in Cairo?

Hampton Inn Cape Girardeau I 55 East, Hampton Inn & Suites Paducah and Auburn Place Hotel & Suites are the best rated hotels based on customer reviews in the last 365 days.

What are the most luxurious hotels in Cairo?

Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destinatio, Quality Inn Cairo I-57 and Travel Inn & Suites - Sikeston are the top 3 luxury hotels near Cairo city center.

What hotels are closest to the city center of Cairo?

Quality Inn Cairo I-57, Super 8 by Wyndham Charleston, and The Riverstone Hotel Charleston-Sikeston are the properties closest to Cairo city center.

What are the best independent hotels in Cairo?

Auburn Place Hotel & Suites, Drury Suites Cape Girardeau and Travel Inn & Suites - Sikeston are the best rated independent hotels (not part of a big brand).

What are the most popular Marriott hotels in Cairo?

Residence Inn by Marriott Paducah, Courtyard by Marriott Cape Girardeau Downtown and Fairfield Inn & Suites by Marriott Paducah are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the best Choice Hotels branded hotels in Cairo?

Comfort Inn & Suites near Six Flags, Comfort Inn Paducah and Quality Inn & Suites Metropolis I-24 are the best rated Choice Hotels branded hotels (based on HotelPlanner reviews score).

What are the best IHG hotels in Cairo?

Holiday Inn Express & Suites Cape Girardeau I 55 by Ihg, Candlewood Suites Paducah by IHG and Candlewood Suites Cape Girardeau by IHG are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

Verified reviews of the city: Cairo, IL

Below are reviews of the city of Cairo, IL from an actual visitor's perspective.

"Spending time with my family"
Score 5.0 / 5

Vincent R., from 26-Jan-2026
The average traveler rating of the city of Cairo, IL shown above is 5.0 out of 5 based on 1 reviews
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