Charleston Missouri Hotels & Motels

Find the perfect hotel in Charleston using our hotel guide provided below. Find discounted hotel accommodations in or close to Charleston, MO for your upcoming individual or group travel. Discover the most popular Charleston, Missouri hotel and motel rooms. Browse the Charleston area hotels to find the perfect lodging! Please use the provided map of the Charleston hotels. Coordinating a group? Get Charleston Group Hotel Rates

Charleston Hotels/Accommodations

Super 8 by Wyndham Charleston MO : 310 South Story
+1-888-389-4121

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New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
310 South Story, Charleston, MO 63834 +1-888-389-4121
  • Two star Highway property
  • Comp. Breakfast
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From$42
Average 3.5 /5 Guest Reviews Call BookMore Details
Quality Inn - Charleston
+1-888-675-2083

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New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
102 Drake St., Charleston, MO 63834 +1-888-675-2083
  • Economy Highway hotel
  • Check-in time: 3:00PM
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From$59
Average 3.0 /5 Guest Reviews Call BookMore Details
Motel 6 Sikeston Mo in SIKESTON
+1-800-716-8490

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New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
110 South Interstate Dr., SIKESTON, MO 63801 +1-800-716-8490 ~11.02 miles west of Charleston
  • Two star hotel
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From$60
Average 3.0 /5 Review Score Call BookMore Details
Best Western Plus Sikeston
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
120 South Interstate Dr., Sikeston, MO 63801 +1-800-805-5223 ~11.05 miles west of Charleston
  • Inexpensive Highway property
  • Hotel has 2 floors
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From$43
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Days Inn and Suites by Wyndham Sikeston : 220 South Interstate Dr.
+1-888-965-1860

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New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
220 South Interstate Dr., Sikeston, MO 63801 +1-888-965-1860 ~11.09 miles west of Charleston
  • Two star property
  • Gym / Fitness Center Available
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From$60
Average 3.0 /5 Read Reviews Call BookMore Details
Quality Inn Cairo I-57
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
13201 Kessler Rd., Cairo, IL 62914 +1-888-788-5576 ~11.20 miles northeast of Charleston
  • Three Star Highway property
  • Hotel has 2 floors
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From$60
Poor 2.0 /5 Hotel Reviews Call BookMore Details
Super 8 by Wyndham Sikeston/Miner Area : 2609 East Malone
+1-888-897-9207

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New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
2609 East Malone, Sikeston, MO 63801 +1-888-897-9207 ~11.36 miles west of Charleston
  • Low priced Convention Center hotel
  • Check in time: 01:00
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From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
Travel Inn & Suites : 100 Matthews Lane
+1-888-311-4278

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New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
100 Matthews Lane, Sikeston, MO 63801 +1-888-311-4278 ~11.37 miles west of Charleston
  • 3 star Highway property
  • Free breakfast available
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From$80
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Comfort Inn
+1-888-469-4795

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New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
109 Matthews Lane, Sikeston, MO 63801 +1-888-469-4795 ~11.40 miles west of Charleston
  • Three Star Highway property
  • Fitness center on property
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From$85
Average 3.0 /5 Hotel Reviews Call BookMore Details
Drury Inn & Suites Sikeston - Sikeston
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
2608 East Malone Ave., Sikeston, MO 63801 +1-888-734-9421 ~11.45 miles west of Charleston
  • Affordable Highway property
  • Check-in time: 3:00 PM
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From$104
Very Good 4.5 /5 Review Score Call BookMore Details
Pear Tree Inn Sikeston - Sikeston
+1-888-841-5292

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New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
2602 East Malone, Sikeston, MO 63801 +1-888-841-5292 ~11.45 miles west of Charleston
  • Mid-scale Suburban hotel
  • Free breakfast available
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From$80
Average 3.0 /5 Reviews Call BookMore Details
Hampton Inn Sikeston in Sikeston
+1-888-455-5160

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New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
1240 Commerce Dr., Sikeston, MO 63801 +1-888-455-5160 ~14.31 miles west of Charleston
  • Mid-scale Rural hotel
  • Comp. Breakfast
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From$80
Average 3.0 /5 Read Reviews Call BookMore Details
Holiday Inn Express & Suites Sikeston Southwest, an IHG Hotel - Sikeston
+1-888-965-8297

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New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
115 Hospitality Dr., Sikeston, MO 63801 +1-888-965-8297 ~14.33 miles west of Charleston
  • 3-star Rural hotel
  • Free breakfast
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From$94
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Americas Best Value Inn Ullin Mounds : 128 Cheekwood Lane
+1-888-906-6358

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New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
128 Cheekwood Lane, Ullin, IL 62992 +1-888-906-6358 ~25.98 miles north of Charleston
  • 2 star hotel
  • Complimentary breakfast is offered
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From$60
Average 3.0 /5 Latest Reviews Call BookMore Details
Courtyard by Marriott Cape Girardeau Downtown : 400 Broadway St.
+1-888-749-6785

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New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
400 Broadway St., Cape Girardeau, MO 63701 +1-888-749-6785 ~28.56 miles north of Charleston
  • Three Star Downtown property
  • 78 rooms in property
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From$80
Very Good 4.0 /5 Read Reviews Call BookMore Details
Candlewood Suites Cape Girardeau, an IHG Hotel in Cape Girardeau
+1-888-878-9982

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New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
485 South Mount Auburn Rd., Cape Girardeau, MO 65703 +1-888-878-9982 ~28.61 miles northwest of Charleston
  • Inexpensive Highway property
  • Fitness center on property
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From$69
Very Good 4.0 /5 Reviews Call BookMore Details
Hampton Inn Cape Girardeau I 55 East
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
207 South Mount Auburn Rd., Cape Girardeau, MO 63703 +1-888-389-4485 ~29.33 miles northwest of Charleston
  • Three Star Highway hotel
  • Hotel has 86 rooms
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From$80
Excellent 5.0 /5 Review Score Call BookMore Details
Victorian Inn & Suites - Cape Girardeau
+1-888-389-4121

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New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
3256 William St., Cape Girardeau, MO 63703 +1-888-389-4121 ~29.40 miles northwest of Charleston
  • Mid-scale Golf Course property
  • Check-in time: 3:00 pm
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From$79
Average 3.0 /5 Guest Reviews Call BookMore Details
Auburn Place Hotel & Suites in Cape Girardeau
+1-888-675-2083

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New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
3265 Williams St., Cape Girardeau, MO 63702 +1-888-675-2083 ~29.41 miles northwest of Charleston
  • Three Star Highway hotel
  • 5 suites in hotel
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From$58
Very Good 4.5 /5 Reviews Call BookMore Details
Holiday Inn Express & Suites Cape Girardeau I 55
+1-800-716-8490

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New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
3253 William St., Cape Girardeau, MO 63701 +1-800-716-8490 ~29.43 miles northwest of Charleston
  • 3 star property
  • Check-in: 11:00
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From$80
Very Good 4.5 /5 Guest Reviews Call BookMore Details
Pear Tree Inn Cape Girardeau West - Cape Girardeau
+1-800-805-5223

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New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
103 Cape West Pkwy., Cape Girardeau, MO 63701 +1-800-805-5223 ~29.49 miles northwest of Charleston
  • Cheap hotel
  • Gym / Fitness Center Available
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From$59
Average 3.0 /5 Latest Reviews Call BookMore Details
Pear Tree Inn Cape Girardeau Medical Center : 3248 William St.
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
3248 William St., Cape Girardeau, MO 63701 +1-888-965-1860 ~29.50 miles northwest of Charleston
  • Low Cost Highway property
  • Hotel has 3 floors
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From$66
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Drury Suites Cape Girardeau : 3303 Campster Dr.
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
3303 Campster Dr., Cape Girardeau, MO 63701 +1-888-788-5576 ~29.60 miles northwest of Charleston
  • 3-star Highway property
  • Check in: 3:00 PM
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From$85
Very Good 4.5 /5 Reviews Call BookMore Details
Drury Lodge - Cape Girardeau
+1-888-897-9207

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New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
104 South Vantage Dr., Cape Girardeau, MO 63701 +1-888-897-9207 ~29.77 miles northwest of Charleston
  • 3-star Highway property
  • Free breakfast
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From$80
Average 3.0 /5 Guest Reviews Call BookMore Details
Drury Plaza Hotel & Conference Center Cape Girardeau
+1-888-311-4278

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New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
3351 Percy Dr., Cape Girardeau, MO 63701 +1-888-311-4278 ~29.79 miles northwest of Charleston
  • Mid-scale hotel
  • 8 floors in hotel
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From$59
Average 3.0 /5 Hotel Reviews Call BookMore Details
Travel Inn - Marston
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
301 Route Ad, Marston, MO 63866 +1-888-469-4795 ~31.28 miles southwest of Charleston
  • Economical Highway hotel
  • 60 rooms in property
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From$40
Poor 2.5 /5 Hotel Reviews Call BookMore Details
Travel Inn - Martson
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
301 State Highway Ad, Martson, MO 63866 +1-888-734-9421 ~31.46 miles southwest of Charleston
  • Economy property
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From$60
Poor 2.5 /5 Guest Reviews Call BookMore Details
Red Roof Inn Marston : 501 South Outer Rd.
+1-888-841-5292

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New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
501 South Outer Rd., Marston, MO 63866 +1-888-841-5292 ~31.61 miles southwest of Charleston
  • 2-star hotel
  • 2 floors in hotel
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From$60
Average 3.0 /5 Reviews Call BookMore Details
Quality Inn - Cape Girardeau
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
2011 North Kingshighway St., Cape Girardeau, MO 63701 Website +1-888-455-5160 ~31.73 miles northwest of Charleston
  • Cheap property
  • 2 suites in hotel
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From$60
Very Good 4.0 /5 Guest Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham Jackson / Cape Girardeau in Jackson
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
3003 South Old Orchard Rd., Jackson, MO 63755 +1-888-965-8297 ~33.46 miles northwest of Charleston
  • Mid-scale Highway hotel
  • Hotel has 4 floors
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From$85
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Comfort Suites Jackson-Cape Girardeau
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
2904 Old Orchard Rd., Jackson, MO 63755 Website +1-888-906-6358 ~33.57 miles northwest of Charleston
  • 3-star Highway hotel
  • Check in time: 3.00 pm
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From$65
Average 3.0 /5 Latest Reviews Call BookMore Details
Residence Inn by Marriott Paducah
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
3900 Coleman Crossing Circle, Paducah, KY 42001 +1-888-749-6785 ~34.97 miles east of Charleston
  • Affordable Suburban hotel
  • Gym is available on property
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From$89
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Pear Tree Inn Paducah
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
5006 Hinkleville Rd., Paducah, KY 42001 +1-888-878-9982 ~35.47 miles east of Charleston
  • 2-star Suburban property
  • Free comp. breakfast
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From$55
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Econo Lodge Dexter
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
913 Outer Rd., Dexter, MO 63841 +1-888-389-4485 ~36.12 miles west of Charleston
  • Economy hotel
  • Free breakfast
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From$60
Average 3.0 /5 Reviews Call BookMore Details
Harrah's Metropolis Hotel & Casino
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
100 East Front St., Metropolis, IL 62960 +1-888-389-4121 ~36.52 miles east of Charleston
  • High-end property
  • Check in time: 16:00
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From$160
Very Good 4.0 /5 Read Reviews Call BookMore Details
Baymont by Wyndham Metropolis - Metropolis
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
203 East Front St., Metropolis, IL 62960 +1-888-675-2083 ~36.55 miles east of Charleston
  • Two-star Riverfront property
  • Access to gym on-site
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From$45
Average 3.0 /5 Reviews Call BookMore Details
Sleep Inn & Mainstay Suites in Union City
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
1111 Blue Heron Lane, Union City, TN 38261 +1-800-716-8490 ~36.64 miles southeast of Charleston
  • Cheap Rural property
  • Hotel has a green policy Learn more
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From$60
Average 3.0 /5 Hotel Reviews Call BookMore Details
Travelodge by Wyndham Dexter
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
1608 West Business U.s. 60, Dexter, MO 63841 +1-800-805-5223 ~36.87 miles west of Charleston
  • 3-star hotel
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From$67
Very Good 4.0 /5 Reviews Call BookMore Details
 Econo Lodge Paducah West I-24 in Paducah
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
5120 Hinkleville Rd., Paducah, KY 42001 +1-888-965-1860 ~37.23 miles east of Charleston
  • Inexpensive Airport hotel
  • Hotel has an eco-friendly policy Read more
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From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
Drury Suites Paducah - Paducah
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
2930 James Sanders Blvd., Paducah, KY 42001 +1-888-788-5576 ~37.34 miles east of Charleston
  • Midscale Suburban property
  • Access to gym on-site
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From$99
Very Good 4.0 /5 Review Score Call BookMore Details
Quality Suites
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
2880 James Sanders Blvd., Paducah, KY 42001 Website +1-888-897-9207 ~37.41 miles east of Charleston
  • Low priced Highway property
  • Free breakfast
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From$60
Average 3.0 /5 Review Score Call BookMore Details
Sleep Inn Union City
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
1111b Blue Heron Lane, Union City, TN 38261 +1-888-311-4278 ~37.44 miles southeast of Charleston
  • Low Cost Rural property
  • Check-in time: 3:00 PM
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From$78
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Comfort Inn & Suites near Six Flags in Lithia Springs
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
960 West Pointe Court, Lithia Springs, GA 30122 Website +1-888-469-4795 ~37.46 miles east of Charleston
  • Mid-scale Downtown hotel
  • Gym / Fitness Center Available
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From$70
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Country Inn & Suites by Radisson, Paducah, KY in Paducah
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
145 Mcbride Lane, Paducah, KY 42001 +1-888-734-9421 ~37.46 miles east of Charleston
  • 3-star Highway hotel
  • 17 suites in hotel
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From$49
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Baymont by Wyndham Paducah in Paducah
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
5300 Old Cairo Rd., Paducah, KY 42001 +1-888-841-5292 ~37.50 miles east of Charleston
  • Three Star property
  • Hotel has 4 suites
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From$40
Poor 2.0 /5 Read Reviews Call BookMore Details
Hotel 7 Inn
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
5001 Hinkleville Rd., Paducah, KY 42001 +1-888-455-5160 ~37.51 miles east of Charleston
  • Two-star property
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From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
Econo Lodge
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
1415 East 5th St., Metropolis, IL 62960 +1-888-965-8297 ~37.60 miles east of Charleston
  • Two-star property
  • 45 rooms in hotel
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From$60
Not Good 1.0 /5 Hotel Reviews Call BookMore Details
Mainstay Suites
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
1111a Blue Heron Lane, Union City, TN 38261 +1-888-906-6358 ~37.65 miles southeast of Charleston
  • 2-star Rural property
  • Check in time: 3:00PM
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From$85
Average 3.0 /5 Latest Reviews Call BookMore Details
Holiday Inn Express : 810 Bream Blvd.
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
810 Bream Blvd., Union City, TN 38261 +1-888-749-6785 ~37.65 miles southeast of Charleston
  • 3 star Rural hotel
  • Gym is available on property
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From$60
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Candlewood Suites Paducah, an IHG Hotel : 3940 Coleman Crossing Circle
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
3940 Coleman Crossing Circle, Paducah, KY 42001 +1-888-878-9982 ~37.65 miles east of Charleston
  • Midscale Rural hotel
  • 85 suites in property
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From$60
Very Good 4.0 /5 Read Reviews Call BookMore Details

Next: See My Charleston Hotels with Pricing

Recent traveler reviews of Charleston, MO

Below are reviews of the city of Charleston, MO from an actual visitor's perspective.

"Easily Accessible"
Score 5.0 / 5

Easily accessible.

Mamon T., from 07-Dec-2023
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