Charleston Missouri Hotels & Motels

Find the perfect hotel in Charleston using our hotel guide provided below. Find discounted hotel accommodations in or close to Charleston, MO for your upcoming individual or group travel. Discover the most popular Charleston, Missouri hotel and motel rooms. Browse the Charleston area hotels to find the perfect lodging! Please use the provided map of the Charleston hotels. Coordinating a group? Get Charleston Group Hotel Rates

Charleston Hotels/Motels & Accommodations

Super 8 by Wyndham Charleston/Sikeston East MO : 310 South Story
+1-888-389-4121

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New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
310 South Story, Charleston, MO 63834 +1-888-389-4121
  • 2-star Highway hotel
  • Hotel has 60 rooms
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From£30
Average 3.5 /5 Latest Reviews Call BookMore Details
Quality Inn Charleston - Sikeston
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
102 Drake St., Charleston, MO 63834 +1-888-675-2083
  • Low Cost Highway property
  • 2 floors in hotel
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From£43
Average 3.0 /5 Guest Reviews Call BookMore Details
Motel 6 Sikeston Mo - SIKESTON
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
110 South Interstate Dr., SIKESTON, MO 63801 +1-800-716-8490 ~11.02 miles west of Charleston
  • 2-star property
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From£44
Average 3.0 /5 Reviews Call BookMore Details
Best Western Plus Sikeston - Sikeston
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
120 South Interstate Dr., Sikeston, MO 63801 +1-800-805-5223 ~11.05 miles west of Charleston
  • Cheap Highway property
  • Hotel has an eco-friendly policy See policy
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From£31
Very good 4.0 /5 Guest Reviews Call BookMore Details
Days Inn and Suites by Wyndham Sikeston : 220 South Interstate Dr.
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
220 South Interstate Dr., Sikeston, MO 63801 +1-888-965-1860 ~11.09 miles west of Charleston
  • Two-star property
  • Check in time: 03:00 PM
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From£44
Average 3.0 /5 Reviews Call BookMore Details
Quality Inn Cairo I-57 : 13201 Kessler Rd.
+1-888-788-5576

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New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
13201 Kessler Rd., Cairo, IL 62914 +1-888-788-5576 ~11.20 miles northeast of Charleston
  • Three Star Highway hotel
  • Hotel has 2 floors
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From£44
Poor 2.0 /5 Latest Reviews Call BookMore Details
Super 8 by Wyndham Sikeston/Miner Area : 2609 East Malone
+1-888-897-9207

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New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
2609 East Malone, Sikeston, MO 63801 +1-888-897-9207 ~11.36 miles west of Charleston
  • Two-star Convention Center property
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From£44
Average 3.0 /5 Latest Reviews Call BookMore Details
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
+1-888-311-4278

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New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
100 Matthews Lane, Sikeston, MO 63801 +1-888-311-4278 ~11.37 miles west of Charleston
  • 3-star Highway hotel
  • 40 sleeping rooms in hotel
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From£58
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Comfort Inn
+1-888-469-4795

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New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
109 Matthews Lane, Sikeston, MO 63801 +1-888-469-4795 ~11.40 miles west of Charleston
  • Mid-scale Highway property
  • Gym is available on property
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From£62
Average 3.0 /5 Reviews Call BookMore Details
Drury Inn & Suites Sikeston : 2608 East Malone Ave.
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
2608 East Malone Ave., Sikeston, MO 63801 +1-888-734-9421 ~11.45 miles west of Charleston
  • 3-star Highway property
  • Fitness + Health Center
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From£76
Very good 4.5 /5 Recent Reviews Call BookMore Details
Pear Tree Inn Sikeston - Sikeston
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
2602 East Malone, Sikeston, MO 63801 +1-888-841-5292 ~11.45 miles west of Charleston
  • Three Star Suburban hotel
  • Gym / Fitness Center Available
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From£58
Average 3.0 /5 Recent Reviews Call BookMore Details
Hampton Inn Sikeston : 1240 Commerce Dr.
+1-888-455-5160

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New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
1240 Commerce Dr., Sikeston, MO 63801 +1-888-455-5160 ~14.31 miles west of Charleston
  • Three Star Rural property
  • 4 floors in hotel
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From£58
Average 3.0 /5 Guest Reviews Call BookMore Details
Holiday Inn Express & Suites Sikeston An Ihg Hotel : 115 Hospitality Dr.
+1-888-965-8297

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New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
115 Hospitality Dr., Sikeston, MO 63801 +1-888-965-8297 ~14.33 miles west of Charleston
  • Mid-scale Rural property
  • 3 floors in hotel
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From£58
Average 3.0 /5 Latest Reviews Call BookMore Details
Americas Best Value Inn Ullin Mounds
+1-888-906-6358

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New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
128 Cheekwood Lane, Ullin, IL 62992 +1-888-906-6358 ~25.98 miles north of Charleston
  • Two star hotel
  • Check in time: 15:00
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From£44
Average 3.0 /5 Reviews Call BookMore Details
Courtyard by Marriott Cape Girardeau Downtown : 400 Broadway St.
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
400 Broadway St., Cape Girardeau, MO 63701 +1-888-749-6785 ~28.56 miles north of Charleston
  • Midscale Downtown property
  • Hotel has 78 rooms
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From£58
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Candlewood Suites Cape Girardeau by IHG - Cape Girardeau
+1-888-878-9982

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New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
485 South Mount Auburn Rd., Cape Girardeau, MO 65703 +1-888-878-9982 ~28.61 miles northwest of Charleston
  • 2 star Highway property
  • Has environment-friendly policy Read more
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From£50
Very good 4.0 /5 Latest Reviews Call BookMore Details
Hampton Inn Cape Girardeau I 55 East : 207 South Mount Auburn Rd.
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
207 South Mount Auburn Rd., Cape Girardeau, MO 63703 +1-888-389-4485 ~29.33 miles northwest of Charleston
  • Affordable Highway property
  • Check-in time: 15:00
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From£58
Excellent 5.0 /5 Guest Reviews Call BookMore Details
Victorian Inn & Suites
+1-888-389-4121

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New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
3256 William St., Cape Girardeau, MO 63703 +1-888-389-4121 ~29.40 miles northwest of Charleston
  • 3-star Golf Course hotel
  • Check in time: 3:00 pm
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From£58
Average 3.0 /5 Latest Reviews Call BookMore Details
Auburn Place Hotel & Suites in Cape Girardeau
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
3265 Williams St., Cape Girardeau, MO 63702 +1-888-675-2083 ~29.41 miles northwest of Charleston
  • Three Star Highway hotel
  • 2 floors in property
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From£42
Very good 4.5 /5 Reviews Call BookMore Details
Holiday Inn Express & Suites Cape Girardeau I 55 : 3253 William St.
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
3253 William St., Cape Girardeau, MO 63701 +1-800-716-8490 ~29.43 miles northwest of Charleston
  • Mid-scale property
  • Gym is available on property
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From£58
Very good 4.5 /5 Read Reviews Call BookMore Details
Fairfield Inn & Suites Cape Girardeau
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
433 Cape West Crossing, Cape Girardeay, MO 63703 +1-800-805-5223 ~29.46 miles northwest of Charleston
  • Midscale property
  • Gym is available on property
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From£58
Average 3.0 /5 Recent Reviews Call BookMore Details
Pear Tree Inn Cape Girardeau West - Cape Girardeau
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
103 Cape West Pkwy., Cape Girardeau, MO 63701 +1-888-965-1860 ~29.49 miles northwest of Charleston
  • Low Cost property
  • Hotel has 2 suites
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From£43
Average 3.0 /5 Review Score Call BookMore Details
Pear Tree Inn Cape Girardeau Medical Center
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
3248 William St., Cape Girardeau, MO 63701 +1-888-788-5576 ~29.50 miles northwest of Charleston
  • 2-star Highway hotel
  • Check in: 3:00 pm
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From£48
Very good 4.0 /5 Reviews Call BookMore Details
Drury Suites Cape Girardeau
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
3303 Campster Dr., Cape Girardeau, MO 63701 +1-888-897-9207 ~29.60 miles northwest of Charleston
  • Three Star Highway property
  • Has environment-friendly policy See more
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From£62
Very good 4.5 /5 Reviews Call BookMore Details
Drury Plaza Hotel & Conference Center Cape Girardeau
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
3351 Percy Dr., Cape Girardeau, MO 63701 +1-888-311-4278 ~29.76 miles northwest of Charleston
  • Affordable hotel
  • Has environment-friendly policy Read more
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From£43
Average 3.0 /5 Latest Reviews Call BookMore Details
Drury Lodge in Cape Girardeau
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
104 South Vantage Dr., Cape Girardeau, MO 63701 +1-888-469-4795 ~29.77 miles northwest of Charleston
  • 3-star Highway hotel
  • Free comp. breakfast
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From£58
Average 3.0 /5 Latest Reviews Call BookMore Details
Travel Inn
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
301 Route Ad, Marston, MO 63866 +1-888-734-9421 ~31.28 miles southwest of Charleston
  • Low-priced Highway property
  • 60 sleeping rooms in hotel
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From£29
Poor 2.5 /5 Reviews Call BookMore Details
Travel Inn : 301 State Highway Ad
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
301 State Highway Ad, Martson, MO 63866 +1-888-841-5292 ~31.46 miles southwest of Charleston
  • Low priced hotel
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From£44
Poor 2.5 /5 Review Score Call BookMore Details
Red Roof Inn Marston : 501 South Outer Rd.
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
501 South Outer Rd., Marston, MO 63866 +1-888-455-5160 ~31.61 miles southwest of Charleston
  • Low Cost property
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From£44
Average 3.0 /5 Hotel Reviews Call BookMore Details
Quality Inn
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
2011 North Kingshighway St., Cape Girardeau, MO 63701 Website +1-888-965-8297 ~31.73 miles northwest of Charleston
  • Inexpensive property
  • Hotel has 2 suites
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From£44
Very good 4.0 /5 Review Score Call BookMore Details
TRU by Hilton Cape Girardeau
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
2520 Veterans Memorial Dr., Cape Girardeau, MO 63701 +1-888-906-6358 ~32.92 miles northwest of Charleston
  • Affordable Highway hotel
  • 90 sleeping rooms in hotel
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From£58
Average 3.0 /5 Read Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham Jackson / Cape Girardeau : 3003 South Old Orchard Rd.
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
3003 South Old Orchard Rd., Jackson, MO 63755 +1-888-749-6785 ~33.46 miles northwest of Charleston
  • Mid-scale Highway hotel
  • Hotel has 9 suites
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From£62
Very good 4.0 /5 Reviews Call BookMore Details
Comfort Suites Jackson-Cape Girardeau : 2904 Old Orchard Rd.
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
2904 Old Orchard Rd., Jackson, MO 63755 Website +1-888-878-9982 ~33.57 miles northwest of Charleston
  • Three Star Highway property
  • Free complimentary breakfast
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From£47
Average 3.0 /5 Hotel Reviews Call BookMore Details
Comfort Suites in Jackson
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
2904 Old Orchard Rd., Jackson, 63755 United States +1-888-389-4485 ~33.57 miles northwest of Charleston
  • Four-star Highway hotel
  • Fitness / Gym is on-site
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From£92
Average 3.0 /5 Guest Reviews Call BookMore Details
Residence Inn by Marriott Paducah - Paducah
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
3900 Coleman Crossing Circle, Paducah, KY 42001 +1-888-389-4121 ~34.97 miles east of Charleston
  • Affordable Suburban hotel
  • Check-in time: 3:00PM
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From£65
Very good 4.0 /5 Latest Reviews Call BookMore Details
Pear Tree Inn Paducah : 5006 Hinkleville Rd.
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
5006 Hinkleville Rd., Paducah, KY 42001 +1-888-675-2083 ~35.47 miles east of Charleston
  • Cheap Suburban property
  • Hotel has a green policy Read more
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From£40
Very good 4.0 /5 Reviews Call BookMore Details
Econo Lodge Dexter - Dexter
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
913 Outer Rd., Dexter, MO 63841 +1-800-716-8490 ~36.12 miles west of Charleston
  • Economical property
  • Free comp. breakfast
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From£44
Average 3.0 /5 Hotel Reviews Call BookMore Details
Harrah's Metropolis Hotel & Casino
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
100 East Front St., Metropolis, IL 62960 +1-800-805-5223 ~36.52 miles east of Charleston
  • Four star hotel
  • 7 floors in property
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From£117
Very good 4.0 /5 Latest Reviews Call BookMore Details
Baymont by Wyndham Metropolis
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
203 East Front St., Metropolis, IL 62960 +1-888-965-1860 ~36.55 miles east of Charleston
  • 2 star Riverfront property
  • Gym is available on property
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From£33
Average 3.0 /5 Read Reviews Call BookMore Details
Sleep Inn & Mainstay Suites : 1111 Blue Heron Lane
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
1111 Blue Heron Lane, Union City, TN 38261 +1-888-788-5576 ~36.64 miles southeast of Charleston
  • Two-star Rural property
  • Check-in time: 15:00
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From£44
Average 3.0 /5 Read Reviews Call BookMore Details
Travelodge by Wyndham Dexter
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
1608 West Business U.s. 60, Dexter, MO 63841 +1-888-897-9207 ~36.87 miles west of Charleston
  • 3 star property
  • Check in: 4
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From£49
Very good 4.0 /5 Recent Reviews Call BookMore Details
 Econo Lodge Paducah West I-24 - Paducah
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
5120 Hinkleville Rd., Paducah, KY 42001 +1-888-311-4278 ~37.23 miles east of Charleston
  • Low Cost Airport property
  • 2 floors in property
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From£44
Average 3.0 /5 Latest Reviews Call BookMore Details
Drury Suites Paducah in Paducah
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
2930 James Sanders Blvd., Paducah, KY 42001 +1-888-469-4795 ~37.34 miles east of Charleston
  • 3 star Suburban hotel
  • Hotel has 6 floors
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From£72
Very good 4.0 /5 Latest Reviews Call BookMore Details
Quality Suites Paducah I-24
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
2880 James Sanders Blvd., Paducah, KY 42001 Website +1-888-734-9421 ~37.41 miles east of Charleston
  • Two-star Highway hotel
  • Hotel has a green policy See policy
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From£44
Average 3.0 /5 Read Reviews Call BookMore Details
Sleep Inn Union City in Union City
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
1111b Blue Heron Lane, Union City, TN 38261 +1-888-841-5292 ~37.44 miles southeast of Charleston
  • Cheap Rural hotel
  • Hotel has an eco-friendly policy See more
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From£57
Very good 4.0 /5 Latest Reviews Call BookMore Details
Comfort Inn & Suites near Six Flags : 960 West Pointe Court
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
960 West Pointe Court, Lithia Springs, GA 30122 Website +1-888-455-5160 ~37.46 miles east of Charleston
  • Mid-scale Downtown property
  • Check-in: 3:00pm
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From£51
Very good 4.0 /5 Latest Reviews Call BookMore Details
Country Inn & Suites by Radisson, Paducah, KY : 145 Mcbride Lane
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
145 Mcbride Lane, Paducah, KY 42001 +1-888-965-8297 ~37.46 miles east of Charleston
  • 3 star Highway property
  • 60 sleeping rooms in hotel
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From£36
Very good 4.0 /5 Review Score Call BookMore Details
Baymont by Wyndham Paducah : 5300 Old Cairo Rd.
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
5300 Old Cairo Rd., Paducah, KY 42001 +1-888-906-6358 ~37.50 miles east of Charleston
  • Midscale hotel
  • Hotel has 3 floors
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From£29
Poor 2.0 /5 Review Score Call BookMore Details
Hotel 7 Inn Paducah in Paducah
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
5001 Hinkleville Rd., Paducah, KY 42001 +1-888-749-6785 ~37.51 miles east of Charleston
  • 2-star property
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From£44
Average 3.0 /5 Recent Reviews Call BookMore Details
Econo Lodge - Metropolis
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
1415 East 5th St., Metropolis, IL 62960 +1-888-878-9982 ~37.60 miles east of Charleston
  • 2-star property
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From£44
Terrible 1.0 /5 Read Reviews Call BookMore Details

Next: See My Charleston Hotels with Pricing

Recent traveler reviews of Charleston, MO

Below are reviews of the city of Charleston, MO from an actual visitor's perspective.

"Easily Accessible"
Score 5.0 / 5

Easily accessible.

Mamon T., from 07-Dec-2023
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