Charleston Missouri Hotels & Motels

Find the perfect hotel in Charleston using our hotel guide provided below. Find discounted hotel accommodations in or close to Charleston, MO for your upcoming individual or group travel. Discover the most popular Charleston, Missouri hotel and motel rooms. Browse the Charleston area hotels to find the perfect lodging! Please use the provided map of the Charleston hotels. Coordinating a group? Get Charleston Group Hotel Rates

Charleston Hotels/Accommodations

Super 8 by Wyndham Charleston/Sikeston East MO : 310 South Story
+1-888-389-4121

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New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
310 South Story, Charleston, MO 63834 +1-888-389-4121
  • Low priced Highway hotel
  • 60 sleeping rooms in hotel
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From$42
Average 3.5 /5 Review Score Call BookMore Details
Quality Inn Charleston - Sikeston : 102 Drake St.
+1-888-675-2083

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New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
102 Drake St., Charleston, MO 63834 +1-888-675-2083
  • Economy Highway hotel
  • Free comp. breakfast
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From$59
Average 3.0 /5 Guest Reviews Call BookMore Details
Motel 6 Sikeston Mo
+1-800-716-8490

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New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
110 South Interstate Dr., SIKESTON, MO 63801 +1-800-716-8490 ~11.02 miles west of Charleston
  • Two star hotel
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From$60
Average 3.0 /5 Review Score Call BookMore Details
Best Western Plus Sikeston
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
120 South Interstate Dr., Sikeston, MO 63801 +1-800-805-5223 ~11.05 miles west of Charleston
  • Inexpensive Highway property
  • 55 sleeping rooms in hotel
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From$43
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Days Inn and Suites by Wyndham Sikeston in Sikeston
+1-888-965-1860

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New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
220 South Interstate Dr., Sikeston, MO 63801 +1-888-965-1860 ~11.09 miles west of Charleston
  • Two-star hotel
  • Check-in: 03:00 PM
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From$60
Average 3.0 /5 Latest Reviews Call BookMore Details
Quality Inn Cairo I-57 : 13201 Kessler Rd.
+1-888-788-5576

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New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
13201 Kessler Rd., Cairo, IL 62914 +1-888-788-5576 ~11.20 miles northeast of Charleston
  • Three Star Highway property
  • 38 rooms in property
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From$60
Poor 2.0 /5 Guest Reviews Call BookMore Details
Super 8 by Wyndham Sikeston/Miner Area : 2609 East Malone
+1-888-897-9207

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New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
2609 East Malone, Sikeston, MO 63801 +1-888-897-9207 ~11.36 miles west of Charleston
  • Inexpensive Convention Center property
  • Comp. Breakfast
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From$60
Average 3.0 /5 Review Score Call BookMore Details
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
+1-888-311-4278

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New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
100 Matthews Lane, Sikeston, MO 63801 +1-888-311-4278 ~11.37 miles west of Charleston
  • 3 star Highway hotel
  • Check in: 3:00 PM
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From$80
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Comfort Inn
+1-888-469-4795

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New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
109 Matthews Lane, Sikeston, MO 63801 +1-888-469-4795 ~11.40 miles west of Charleston
  • Mid-scale Highway hotel
  • Check in: 11:00
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From$85
Average 3.0 /5 Recent Reviews Call BookMore Details
Drury Inn & Suites Sikeston
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
2608 East Malone Ave., Sikeston, MO 63801 +1-888-734-9421 ~11.45 miles west of Charleston
  • Mid-scale Highway hotel
  • Access to gym on-site
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From$104
Very Good 4.5 /5 Guest Reviews Call BookMore Details
Pear Tree Inn Sikeston
+1-888-841-5292

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New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
2602 East Malone, Sikeston, MO 63801 +1-888-841-5292 ~11.45 miles west of Charleston
  • Midscale Suburban property
  • Free complimentary breakfast
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From$80
Average 3.0 /5 Latest Reviews Call BookMore Details
Hampton Inn Sikeston - Sikeston
+1-888-455-5160

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New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
1240 Commerce Dr., Sikeston, MO 63801 +1-888-455-5160 ~14.31 miles west of Charleston
  • Affordable Rural property
  • Hotel has 4 floors
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From$80
Average 3.0 /5 Reviews Call BookMore Details
Holiday Inn Express & Suites Sikeston An Ihg Hotel in Sikeston
+1-888-965-8297

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New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
115 Hospitality Dr., Sikeston, MO 63801 +1-888-965-8297 ~14.33 miles west of Charleston
  • Midscale Rural property
  • 3 floors in property
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From$80
Average 3.0 /5 Review Score Call BookMore Details
Americas Best Value Inn Ullin Mounds : 128 Cheekwood Lane
+1-888-906-6358

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New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
128 Cheekwood Lane, Ullin, IL 62992 +1-888-906-6358 ~25.98 miles north of Charleston
  • Two-star hotel
  • 40 sleeping rooms in hotel
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From$60
Average 3.0 /5 Latest Reviews Call BookMore Details
Courtyard by Marriott Cape Girardeau Downtown
+1-888-749-6785

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New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
400 Broadway St., Cape Girardeau, MO 63701 +1-888-749-6785 ~28.56 miles north of Charleston
  • 3 star Downtown hotel
  • Fitness + Health Center
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From$80
Very Good 4.0 /5 Read Reviews Call BookMore Details
Candlewood Suites Cape Girardeau by IHG
+1-888-878-9982

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New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
485 South Mount Auburn Rd., Cape Girardeau, MO 65703 +1-888-878-9982 ~28.61 miles northwest of Charleston
  • 2 star Highway hotel
  • Fitness + Health Center
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From$69
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Hampton Inn Cape Girardeau I 55 East in Cape Girardeau
+1-888-389-4485

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New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
207 South Mount Auburn Rd., Cape Girardeau, MO 63703 +1-888-389-4485 ~29.33 miles northwest of Charleston
  • 3 star Highway property
  • Complimentary breakfast is offered
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From$80
Excellent 5.0 /5 Review Score Call BookMore Details
Victorian Inn & Suites
+1-888-389-4121

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New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
3256 William St., Cape Girardeau, MO 63703 +1-888-389-4121 ~29.40 miles northwest of Charleston
  • 3-star Golf Course hotel
  • 5 suites in property
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From$79
Average 3.0 /5 Review Score Call BookMore Details
Auburn Place Hotel & Suites
+1-888-675-2083

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New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
3265 Williams St., Cape Girardeau, MO 63702 +1-888-675-2083 ~29.41 miles northwest of Charleston
  • Mid-scale Highway property
  • 133 sleeping rooms in hotel
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From$58
Very Good 4.5 /5 Reviews Call BookMore Details
Holiday Inn Express & Suites Cape Girardeau I 55 - Cape Girardeau
+1-800-716-8490

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New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
3253 William St., Cape Girardeau, MO 63701 +1-800-716-8490 ~29.43 miles northwest of Charleston
  • Mid-scale hotel
  • 102 suites in property
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From$80
Very Good 4.5 /5 Hotel Reviews Call BookMore Details
Fairfield Inn & Suites Cape Girardeau
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
433 Cape West Crossing, Cape Girardeay, MO 63703 +1-800-805-5223 ~29.46 miles northwest of Charleston
  • 3-star property
  • Fitness / Gym is on-site
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From$80
Average 3.0 /5 Read Reviews Call BookMore Details
Pear Tree Inn Cape Girardeau West
+1-888-965-1860

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New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
103 Cape West Pkwy., Cape Girardeau, MO 63701 +1-888-965-1860 ~29.49 miles northwest of Charleston
  • Cheap property
  • Check-in time: 3:00 PM
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From$59
Average 3.0 /5 Review Score Call BookMore Details
Pear Tree Inn Cape Girardeau Medical Center - Cape Girardeau
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
3248 William St., Cape Girardeau, MO 63701 +1-888-788-5576 ~29.50 miles northwest of Charleston
  • Cheap Highway property
  • Check-in time: 3:00 pm
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From$66
Very Good 4.0 /5 Review Score Call BookMore Details
Drury Suites Cape Girardeau - Cape Girardeau
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
3303 Campster Dr., Cape Girardeau, MO 63701 +1-888-897-9207 ~29.60 miles northwest of Charleston
  • Midscale Highway property
  • 86 rooms in property
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From$85
Very Good 4.5 /5 Guest Reviews Call BookMore Details
Drury Plaza Hotel & Conference Center Cape Girardeau
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
3351 Percy Dr., Cape Girardeau, MO 63701 +1-888-311-4278 ~29.76 miles northwest of Charleston
  • 3 star hotel
  • 8 floors in property
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From$59
Average 3.0 /5 Reviews Call BookMore Details
Drury Lodge in Cape Girardeau
+1-888-469-4795

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New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
104 South Vantage Dr., Cape Girardeau, MO 63701 +1-888-469-4795 ~29.77 miles northwest of Charleston
  • Midscale Highway property
  • Check-in time: 3:00pm
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From$80
Average 3.0 /5 Latest Reviews Call BookMore Details
Travel Inn : 301 Route Ad
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
301 Route Ad, Marston, MO 63866 +1-888-734-9421 ~31.28 miles southwest of Charleston
  • Cheap Highway property
  • Free breakfast
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From$40
Poor 2.5 /5 Reviews Call BookMore Details
Travel Inn : 301 State Highway Ad
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
301 State Highway Ad, Martson, MO 63866 +1-888-841-5292 ~31.46 miles southwest of Charleston
  • Economical hotel
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From$60
Poor 2.5 /5 Hotel Reviews Call BookMore Details
Red Roof Inn Marston in Marston
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
501 South Outer Rd., Marston, MO 63866 +1-888-455-5160 ~31.61 miles southwest of Charleston
  • Cheap property
  • 2 floors in hotel
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From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
Quality Inn
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
2011 North Kingshighway St., Cape Girardeau, MO 63701 Website +1-888-965-8297 ~31.73 miles northwest of Charleston
  • Low priced property
  • 2 suites in property
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From$60
Very Good 4.0 /5 Latest Reviews Call BookMore Details
TRU by Hilton Cape Girardeau in Cape Girardeau
+1-888-906-6358

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New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
2520 Veterans Memorial Dr., Cape Girardeau, MO 63701 +1-888-906-6358 ~32.92 miles northwest of Charleston
  • Affordable Highway hotel
  • 4 floors in property
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From$80
Average 3.0 /5 Hotel Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham Jackson / Cape Girardeau
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
3003 South Old Orchard Rd., Jackson, MO 63755 +1-888-749-6785 ~33.46 miles northwest of Charleston
  • Affordable Highway hotel
  • Complimentary breakfast is offered
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From$85
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Comfort Suites
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
2904 Old Orchard Rd., Jackson, MO 63755 +1-888-878-9982 ~33.57 miles northwest of Charleston
  • 3 star Highway property
  • Fitness / Gym is on-site
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From$80
Average 3.0 /5 Recent Reviews Call BookMore Details
Residence Inn by Marriott Paducah : 3900 Coleman Crossing Circle
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
3900 Coleman Crossing Circle, Paducah, KY 42001 +1-888-389-4485 ~34.97 miles east of Charleston
  • Three Star Suburban hotel
  • 74 rooms in property
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From$89
Very Good 4.0 /5 Reviews Call BookMore Details
Pear Tree Inn Paducah - Paducah
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
5006 Hinkleville Rd., Paducah, KY 42001 +1-888-389-4121 ~35.47 miles east of Charleston
  • Cheap Suburban property
  • 59 rooms in hotel
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From$55
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Econo Lodge Dexter in Dexter
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
913 Outer Rd., Dexter, MO 63841 +1-888-675-2083 ~36.12 miles west of Charleston
  • Economical property
  • 38 rooms in hotel
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From$60
Average 3.0 /5 Hotel Reviews Call BookMore Details
Harrah's Metropolis Hotel & Casino in Metropolis
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
100 East Front St., Metropolis, IL 62960 +1-800-716-8490 ~36.52 miles east of Charleston
  • Four-star hotel
  • 7 floors in hotel
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From$160
Very Good 4.0 /5 Read Reviews Call BookMore Details
Baymont by Wyndham Metropolis in Metropolis
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
203 East Front St., Metropolis, IL 62960 +1-800-805-5223 ~36.55 miles east of Charleston
  • Two star Riverfront hotel
  • Check-in: 3:00PM
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From$45
Average 3.0 /5 Review Score Call BookMore Details
Sleep Inn & Mainstay Suites : 1111 Blue Heron Lane
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
1111 Blue Heron Lane, Union City, TN 38261 +1-888-965-1860 ~36.64 miles southeast of Charleston
  • 2-star Rural property
  • 40 rooms in property
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From$60
Average 3.0 /5 Hotel Reviews Call BookMore Details
Travelodge by Wyndham Dexter in Dexter
+1-888-788-5576

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New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
1608 West Business U.s. 60, Dexter, MO 63841 +1-888-788-5576 ~36.87 miles west of Charleston
  • 3-star hotel
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From$67
Very Good 4.0 /5 Read Reviews Call BookMore Details
 Econo Lodge Paducah West I-24
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
5120 Hinkleville Rd., Paducah, KY 42001 +1-888-897-9207 ~37.23 miles east of Charleston
  • Economy Airport hotel
  • Hotel has a green policy Learn more
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From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
Drury Suites Paducah - Paducah
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
2930 James Sanders Blvd., Paducah, KY 42001 +1-888-311-4278 ~37.34 miles east of Charleston
  • Midscale Suburban property
  • Hotel has 120 suites
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From$99
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Quality Suites Paducah I-24
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
2880 James Sanders Blvd., Paducah, KY 42001 Website +1-888-469-4795 ~37.41 miles east of Charleston
  • Cheap Highway hotel
  • Free comp. breakfast
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From$60
Average 3.0 /5 Reviews Call BookMore Details
Sleep Inn Union City : 1111b Blue Heron Lane
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
1111b Blue Heron Lane, Union City, TN 38261 +1-888-734-9421 ~37.44 miles southeast of Charleston
  • Economy Rural hotel
  • Check-in: 3:00 PM
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From$78
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Comfort Inn & Suites near Six Flags
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
960 West Pointe Court, Lithia Springs, GA 30122 Website +1-888-841-5292 ~37.46 miles east of Charleston
  • Midscale Downtown hotel
  • Comp. Breakfast
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From$70
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Country Inn & Suites by Radisson, Paducah, KY in Paducah
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
145 Mcbride Lane, Paducah, KY 42001 +1-888-455-5160 ~37.46 miles east of Charleston
  • 3-star Highway property
  • Check in: 3pm
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From$49
Very Good 4.0 /5 Read Reviews Call BookMore Details
Baymont by Wyndham Paducah - Paducah
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
5300 Old Cairo Rd., Paducah, KY 42001 +1-888-965-8297 ~37.50 miles east of Charleston
  • Affordable property
  • Hotel has 3 floors
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From$40
Poor 2.0 /5 Guest Reviews Call BookMore Details
Hotel 7 Inn Paducah in Paducah
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
5001 Hinkleville Rd., Paducah, KY 42001 +1-888-906-6358 ~37.51 miles east of Charleston
  • Two star hotel
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From$60
Average 3.0 /5 Read Reviews Call BookMore Details
Econo Lodge
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
1415 East 5th St., Metropolis, IL 62960 +1-888-749-6785 ~37.60 miles east of Charleston
  • 2-star hotel
  • 45 rooms in hotel
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From$60
Not Good 1.0 /5 Read Reviews Call BookMore Details
Mainstay Suites
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
1111a Blue Heron Lane, Union City, TN 38261 +1-888-878-9982 ~37.65 miles southeast of Charleston
  • Inexpensive Rural hotel
  • 3 floors in property
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From$85
Average 3.0 /5 Recent Reviews Call BookMore Details

Next: See My Charleston Hotels with Pricing

Recent traveler reviews of Charleston, MO

Below are reviews of the city of Charleston, MO from an actual visitor's perspective.

"Easily Accessible"
Score 5.0 / 5

Easily accessible.

Mamon T., from 07-Dec-2023
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