Charleston Missouri Hotels & Motels

Find the perfect hotel in Charleston using our hotel guide provided below. Find discounted hotel accommodations in or close to Charleston, MO for your upcoming individual or group travel. Discover the most popular Charleston, Missouri hotel and motel rooms. Browse the Charleston area hotels to find the perfect lodging! Please use the provided map of the Charleston hotels. Coordinating a group? Get Charleston Group Hotel Rates

Charleston Hotels/Motels & Accommodations

Super 8 by Wyndham Charleston/Sikeston East MO
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
310 South Story, Charleston, MO 63834 +1-888-389-4121
  • Economy Highway property
  • Comp. Breakfast
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From$42
Average 3.5 /5 Recent Reviews Call BookMore Details
Quality Inn Charleston - Sikeston
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
102 Drake St., Charleston, MO 63834 +1-888-675-2083
  • Low Cost Highway property
  • 9 suites in hotel
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From$59
Average 3.0 /5 Reviews Call BookMore Details
Motel 6 Sikeston Mo - SIKESTON
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
110 South Interstate Dr., SIKESTON, MO 63801 +1-800-716-8490 ~11.02 miles west of Charleston
  • Low Cost property
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From$60
Average 3.0 /5 Review Score Call BookMore Details
Best Western Plus Sikeston
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
120 South Interstate Dr., Sikeston, MO 63801 +1-800-805-5223 ~11.05 miles west of Charleston
  • Low priced Highway property
  • 55 rooms in property
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From$43
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Days Inn and Suites by Wyndham Sikeston : 220 South Interstate Dr.
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
220 South Interstate Dr., Sikeston, MO 63801 +1-888-965-1860 ~11.09 miles west of Charleston
  • Low Cost hotel
  • Check-in time: 03:00 PM
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From$60
Average 3.0 /5 Recent Reviews Call BookMore Details
Quality Inn Cairo I-57 in Cairo
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
13201 Kessler Rd., Cairo, IL 62914 +1-888-788-5576 ~11.20 miles northeast of Charleston
  • 3 star Highway hotel
  • Hotel has 2 floors
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From$60
Poor 2.0 /5 Guest Reviews Call BookMore Details
Super 8 by Wyndham Sikeston/Miner Area
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
2609 East Malone, Sikeston, MO 63801 +1-888-897-9207 ~11.36 miles west of Charleston
  • Low Cost Convention Center hotel
  • Free breakfast
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From$60
Average 3.0 /5 Reviews Call BookMore Details
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) in Sikeston
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
100 Matthews Lane, Sikeston, MO 63801 +1-888-311-4278 ~11.37 miles west of Charleston
  • Three Star Highway hotel
  • Check in time: 3:00 PM
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From$80
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Comfort Inn - Sikeston
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
109 Matthews Lane, Sikeston, MO 63801 +1-888-469-4795 ~11.40 miles west of Charleston
  • 3-star Highway hotel
  • Fitness + Health Center
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From$85
Average 3.0 /5 Latest Reviews Call BookMore Details
Drury Inn & Suites Sikeston : 2608 East Malone Ave.
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
2608 East Malone Ave., Sikeston, MO 63801 +1-888-734-9421 ~11.45 miles west of Charleston
  • Affordable Highway property
  • Hotel has an eco-friendly policy See policy
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From$104
Very Good 4.5 /5 Latest Reviews Call BookMore Details
Pear Tree Inn Sikeston
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
2602 East Malone, Sikeston, MO 63801 +1-888-841-5292 ~11.45 miles west of Charleston
  • Mid-scale Suburban property
  • Hotel has an eco-friendly policy Read more
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From$80
Average 3.0 /5 Reviews Call BookMore Details
Hampton Inn Sikeston : 1240 Commerce Dr.
+1-888-455-5160

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New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
1240 Commerce Dr., Sikeston, MO 63801 +1-888-455-5160 ~14.31 miles west of Charleston
  • 3-star Rural property
  • Access to gym on-site
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From$80
Average 3.0 /5 Guest Reviews Call BookMore Details
Holiday Inn Express & Suites Sikeston An Ihg Hotel : 115 Hospitality Dr.
+1-888-965-8297

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New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
115 Hospitality Dr., Sikeston, MO 63801 +1-888-965-8297 ~14.33 miles west of Charleston
  • Midscale Rural property
  • Check in: 3:00pm
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From$80
Average 3.0 /5 Recent Reviews Call BookMore Details
Americas Best Value Inn Ullin Mounds : 128 Cheekwood Lane
+1-888-906-6358

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New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
128 Cheekwood Lane, Ullin, IL 62992 +1-888-906-6358 ~25.98 miles north of Charleston
  • Two star property
  • Check in time: 15:00
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From$60
Average 3.0 /5 Latest Reviews Call BookMore Details
Courtyard by Marriott Cape Girardeau Downtown
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
400 Broadway St., Cape Girardeau, MO 63701 +1-888-749-6785 ~28.56 miles north of Charleston
  • 3 star Downtown property
  • Fitness + Health Center
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From$80
Very Good 4.0 /5 Reviews Call BookMore Details
Candlewood Suites Cape Girardeau, an IHG Hotel in Cape Girardeau
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
485 South Mount Auburn Rd., Cape Girardeau, MO 65703 +1-888-878-9982 ~28.61 miles northwest of Charleston
  • Cheap Highway hotel
  • Has environment-friendly policy Learn more
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From$69
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Hampton Inn Cape Girardeau I 55 East
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
207 South Mount Auburn Rd., Cape Girardeau, MO 63703 +1-888-389-4485 ~29.33 miles northwest of Charleston
  • Three Star Highway property
  • 86 sleeping rooms in hotel
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From$80
Excellent 5.0 /5 Read Reviews Call BookMore Details
Victorian Inn & Suites : 3256 William St.
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
3256 William St., Cape Girardeau, MO 63703 +1-888-389-4121 ~29.40 miles northwest of Charleston
  • Affordable Golf Course hotel
  • Check in time: 3:00 pm
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From$79
Average 3.0 /5 Review Score Call BookMore Details
Auburn Place Hotel & Suites - Cape Girardeau
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
3265 Williams St., Cape Girardeau, MO 63702 +1-888-675-2083 ~29.41 miles northwest of Charleston
  • 3-star Highway property
  • Gym is available on property
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From$58
Very Good 4.5 /5 Reviews Call BookMore Details
Holiday Inn Express & Suites Cape Girardeau I 55 : 3253 William St.
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
3253 William St., Cape Girardeau, MO 63701 +1-800-716-8490 ~29.43 miles northwest of Charleston
  • Three Star property
  • Check in time: 11:00
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From$80
Very Good 4.5 /5 Recent Reviews Call BookMore Details
Fairfield Inn & Suites Cape Girardeau in Cape Girardeay
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
433 Cape West Crossing, Cape Girardeay, MO 63703 +1-800-805-5223 ~29.46 miles northwest of Charleston
  • Midscale property
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From$80
Average 3.0 /5 Guest Reviews Call BookMore Details
Pear Tree Inn Cape Girardeau West
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
103 Cape West Pkwy., Cape Girardeau, MO 63701 +1-888-965-1860 ~29.49 miles northwest of Charleston
  • Two star property
  • Access to gym on-site
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From$59
Average 3.0 /5 Review Score Call BookMore Details
Pear Tree Inn Cape Girardeau Medical Center : 3248 William St.
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
3248 William St., Cape Girardeau, MO 63701 +1-888-788-5576 ~29.50 miles northwest of Charleston
  • Economy Highway property
  • Hotel has an eco-friendly policy Learn more
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From$66
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Drury Suites Cape Girardeau
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
3303 Campster Dr., Cape Girardeau, MO 63701 +1-888-897-9207 ~29.60 miles northwest of Charleston
  • Affordable Highway hotel
  • Hotel has an eco-friendly policy Read more
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From$85
Very Good 4.5 /5 Guest Reviews Call BookMore Details
Drury Plaza Hotel & Conference Center Cape Girardeau - Cape Girardeau
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
3351 Percy Dr., Cape Girardeau, MO 63701 +1-888-311-4278 ~29.76 miles northwest of Charleston
  • Three Star property
  • Access to gym on-site
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From$59
Average 3.0 /5 Guest Reviews Call BookMore Details
Drury Lodge in Cape Girardeau
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
104 South Vantage Dr., Cape Girardeau, MO 63701 +1-888-469-4795 ~29.77 miles northwest of Charleston
  • 3 star Highway property
  • Free breakfast available
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From$80
Average 3.0 /5 Read Reviews Call BookMore Details
Travel Inn in Marston
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
301 Route Ad, Marston, MO 63866 +1-888-734-9421 ~31.28 miles southwest of Charleston
  • Inexpensive Highway hotel
  • Hotel has 60 rooms
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From$40
Poor 2.5 /5 Hotel Reviews Call BookMore Details
Travel Inn
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
301 State Highway Ad, Martson, MO 63866 +1-888-841-5292 ~31.46 miles southwest of Charleston
  • Cheap property
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From$60
Poor 2.5 /5 Reviews Call BookMore Details
Red Roof Inn Marston
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
501 South Outer Rd., Marston, MO 63866 +1-888-455-5160 ~31.61 miles southwest of Charleston
  • Economy property
  • Hotel has 2 floors
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From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
Quality Inn
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
2011 North Kingshighway St., Cape Girardeau, MO 63701 Website +1-888-965-8297 ~31.73 miles northwest of Charleston
  • Economy hotel
  • 2 suites in hotel
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From$60
Very Good 4.0 /5 Latest Reviews Call BookMore Details
TRU by Hilton Cape Girardeau in Cape Girardeau
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
2520 Veterans Memorial Dr., Cape Girardeau, MO 63701 +1-888-906-6358 ~32.92 miles northwest of Charleston
  • 3-star Riverfront property
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From$80
Average 3.0 /5 Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham Jackson / Cape Girardeau : 3003 South Old Orchard Rd.
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
3003 South Old Orchard Rd., Jackson, MO 63755 +1-888-749-6785 ~33.46 miles northwest of Charleston
  • Midscale Highway property
  • Free breakfast
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From$85
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Comfort Suites Jackson-Cape Girardeau
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
2904 Old Orchard Rd., Jackson, MO 63755 Website +1-888-878-9982 ~33.57 miles northwest of Charleston
  • 3 star Highway property
  • 64 suites in hotel
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From$65
Average 3.0 /5 Read Reviews Call BookMore Details
Comfort Suites : 2904 Old Orchard Rd.
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
2904 Old Orchard Rd., Jackson, 63755 United States +1-888-389-4485 ~33.57 miles northwest of Charleston
  • 4 star Highway property
  • Hotel has 64 suites
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From$125
Average 3.0 /5 Recent Reviews Call BookMore Details
Residence Inn by Marriott Paducah - Paducah
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
3900 Coleman Crossing Circle, Paducah, KY 42001 +1-888-389-4121 ~34.97 miles east of Charleston
  • 3-star Suburban hotel
  • 74 rooms in property
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From$89
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Pear Tree Inn Paducah : 5006 Hinkleville Rd.
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
5006 Hinkleville Rd., Paducah, KY 42001 +1-888-675-2083 ~35.47 miles east of Charleston
  • Two star Suburban property
  • Check in time: 3:00 PM
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From$55
Very Good 4.0 /5 Read Reviews Call BookMore Details
Econo Lodge Dexter
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
913 Outer Rd., Dexter, MO 63841 +1-800-716-8490 ~36.12 miles west of Charleston
  • Cheap hotel
  • 38 sleeping rooms in hotel
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From$60
Average 3.0 /5 Recent Reviews Call BookMore Details
Harrah's Metropolis Hotel & Casino - Metropolis
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
100 East Front St., Metropolis, IL 62960 +1-800-805-5223 ~36.52 miles east of Charleston
  • Expensive hotel
  • Hotel has 252 rooms
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From$160
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Baymont by Wyndham Metropolis in Metropolis
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
203 East Front St., Metropolis, IL 62960 +1-888-965-1860 ~36.55 miles east of Charleston
  • Low priced Riverfront hotel
  • Hotel has 8 suites
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From$45
Average 3.0 /5 Reviews Call BookMore Details
Sleep Inn & Mainstay Suites : 1111 Blue Heron Lane
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
1111 Blue Heron Lane, Union City, TN 38261 +1-888-788-5576 ~36.64 miles southeast of Charleston
  • Inexpensive Rural hotel
  • 40 rooms in hotel
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From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
Travelodge by Wyndham Dexter
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
1608 West Business U.s. 60, Dexter, MO 63841 +1-888-897-9207 ~36.87 miles west of Charleston
  • 3-star hotel
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From$67
Very Good 4.0 /5 Read Reviews Call BookMore Details
 Econo Lodge Paducah West I-24 : 5120 Hinkleville Rd.
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
5120 Hinkleville Rd., Paducah, KY 42001 +1-888-311-4278 ~37.23 miles east of Charleston
  • Low priced Airport property
  • 75 rooms in hotel
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From$60
Average 3.0 /5 Recent Reviews Call BookMore Details
Drury Suites Paducah
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
2930 James Sanders Blvd., Paducah, KY 42001 +1-888-469-4795 ~37.34 miles east of Charleston
  • Midscale Suburban property
  • 6 floors in hotel
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From$99
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Quality Suites Paducah I-24 in Paducah
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
2880 James Sanders Blvd., Paducah, KY 42001 Website +1-888-734-9421 ~37.41 miles east of Charleston
  • Cheap Highway hotel
  • Fitness center on property
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From$60
Average 3.0 /5 Recent Reviews Call BookMore Details
Sleep Inn Union City - Union City
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
1111b Blue Heron Lane, Union City, TN 38261 +1-888-841-5292 ~37.44 miles southeast of Charleston
  • 2 star Rural hotel
  • 9 suites in hotel
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From$78
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Comfort Inn & Suites near Six Flags
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
960 West Pointe Court, Lithia Springs, GA 30122 Website +1-888-455-5160 ~37.46 miles east of Charleston
  • 3-star Downtown property
  • 5 suites in hotel
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From$70
Very Good 4.0 /5 Review Score Call BookMore Details
Country Inn & Suites by Radisson, Paducah, KY in Paducah
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
145 Mcbride Lane, Paducah, KY 42001 +1-888-965-8297 ~37.46 miles east of Charleston
  • Mid-scale Highway property
  • 17 suites in hotel
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From$49
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Baymont by Wyndham Paducah : 5300 Old Cairo Rd.
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
5300 Old Cairo Rd., Paducah, KY 42001 +1-888-906-6358 ~37.50 miles east of Charleston
  • 3 star property
  • Check-in: 15:00
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From$40
Poor 2.0 /5 Latest Reviews Call BookMore Details
Hotel 7 Inn in Paducah
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
5001 Hinkleville Rd., Paducah, KY 42001 +1-888-749-6785 ~37.51 miles east of Charleston
  • 2-star property
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From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
Econo Lodge in Metropolis
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
1415 East 5th St., Metropolis, IL 62960 +1-888-878-9982 ~37.60 miles east of Charleston
  • Inexpensive hotel
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From$60
Not Good 1.0 /5 Hotel Reviews Call BookMore Details

Next: See My Charleston Hotels with Pricing

Recent traveler reviews of Charleston, MO

Below are reviews of the city of Charleston, MO from an actual visitor's perspective.

"Easily Accessible"
Score 5.0 / 5

Easily accessible.

Mamon T., from 07-Dec-2023
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