Santee South Carolina Accommodations

Find the perfect hotel in Santee using our hotel guide provided below. Search for the cheapest discounted hotel and motel rates in or near Santee, SC for your upcoming personal or group trip. Discover the most favored Santee South Carolina hotel/motel rooms. Review the Santee hotel list below to find the perfect lodging. We also have a map of the Santee hotels. Coordinating a group? Get Santee Group Hotel Discounts

The Santee center point is around 2 miles west of Lake Marion Resort and Marina and 18 miles east of Edisto Memorial Gardens.

"What Is There to See in Santee, SC?"

Southern hospitality abounds in Santee, South Carolina. Located conveniently off Interstate 95, this small town of just under 1000 people hosts 100,000 visitors each year. Lake Marion, Santee State Park, Santee National Golf Club, and the Santee National Wildlife Refuge offer year-round golf, hiking, fishing, water sports, and birding. With so much to do in all seasons, Santee is ideal for outdoor enthusiasts looking to explore the great outdoors. More from this guide...

Santee Hotels & Accommodations

Oyo Hotel Santee Sc Lake Mario
+1-888-389-4121
628 Bass Dr., Charleston, SC 29142 +1-888-389-4121 ~0.30 miles northeast of Santee
  • Midscale hotel
  • 40 sleeping rooms in hotel
From$90
Average 3.0 /5 Read Reviews Call BookMore Details
Holiday Inn Santee - Santee
+1-888-675-2083
139 Bradford Blvd., Santee, SC 29142 +1-888-675-2083
  • Midscale Highway hotel
  • Check in: 3.00pm
From$99
Average 3.0 /5 Read Reviews Call BookMore Details
Comfort Inn & Suites Santee
+1-800-716-8490
221 Britain St., Santee, SC 29142 +1-800-716-8490
  • Cheap Lake hotel
  • Free complimentary breakfast
From$79
Average 3.0 /5 Review Score Call BookMore Details
Baymont by Wyndham Santee in Santee
+1-800-805-5223
249 Britain St., Santee, SC 29142 +1-800-805-5223
  • Mid-scale Highway hotel
  • Check-in time: 3pm
From$80
Average 3.0 /5 Guest Reviews Call BookMore Details
Red Roof Inn Santee
+1-888-965-1860
9091 Old No 6 Highway, Santee, SC 29142 +1-888-965-1860
  • Low-priced Golf Course hotel
  • Check-in time: 1.00
From$49
Average 3.0 /5 Reviews Call BookMore Details
Quality Inn & Suites Santee I-95 : 8929 Bass Dr.
+1-888-788-5576
8929 Bass Dr., Santee, SC 29142 +1-888-788-5576
  • Low Cost Golf Course property
  • 17 suites in hotel
From$56
Average 3.0 /5 Recent Reviews Call BookMore Details
Quality Inn & Suites
+1-888-897-9207
8929 Old Number Six Highway, Santee, SC 29142 +1-888-897-9207
  • Three Star Highway property
  • Check in time: 3 pm
From$80
Average 3.0 /5 Review Score Call BookMore Details
Rodeway Inn Santee I-95 - Santee
+1-888-311-4278
123 Mall St., Santee, SC 29142 +1-888-311-4278
  • Economical Highway property
  • 105 sleeping rooms in hotel
From$60
Average 3.0 /5 Recent Reviews Call BookMore Details
Hampton Inn Santee I 95 in Santee
+1-888-469-4795
9060 Old #6 Highway, Santee, SC 29142 +1-888-469-4795
  • 3-star Highway hotel
  • Fitness / Gym is on-site
From$91
Very Good 4.0 /5 Reviews Call BookMore Details
Best Western Plus Santee Inn
+1-888-734-9421
9059 Old Number Six Highway, Santee, SC 29142 +1-888-734-9421
  • Cheap property
  • Check-in time: 01:00
From$39
Very Good 4.5 /5 Read Reviews Call BookMore Details
Fairfield Inn & Suites by Marriott
+1-888-841-5292
9074 Old Highway Number Six, Santee, SC 29142 +1-888-841-5292
  • 3-star Highway property
  • Hotel has 4 floors
From$90
Excellent 5.0 /5 Hotel Reviews Call BookMore Details
Econo Lodge in Santee
+1-888-455-5160
9112 Old Number 6 Highway, Santee, SC 29142 +1-888-455-5160
  • Cheap Highway property
  • Hotel has 37 rooms
From$60
Average 3.0 /5 Reviews Call BookMore Details
Travelodge by Wyndham Santee - Santee
+1-888-965-8297
9117 Old Number 6 Highway, Santee, SC 29142 +1-888-965-8297
  • Economical Highway property
  • Complimentary breakfast is offered
From$60
Average 3.0 /5 Latest Reviews Call BookMore Details
Super 8 by Wyndham Santee : 9125 Old Highway 6
+1-888-906-6358
9125 Old Highway 6, Santee, SC 29142 +1-888-906-6358
  • Economical Highway property
  • Check-in time: 2pm
From$60
Average 3.0 /5 Review Score Call BookMore Details
Wyndham Vacation Resorts Lake Mario in Santee
+1-888-749-6785
401 Bass Dr., Santee, SC 29412 +1-888-749-6785
  • 3-star hotel
  • 2 sleeping rooms in hotel
From$90
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Days Inn by Wyndham Summerton - Summerton
+1-888-878-9982
400 Buff Blvd., Summerton, SC 29148 +1-888-878-9982 ~10.34 miles northeast of Santee
  • 2 star property
  • Check in time: 11:00 AM
From$60
Average 3.0 /5 Reviews Call BookMore Details
Days Inn by Wyndham Orangeburg South : 3402 Five Chop Rd.
+1-888-389-4485
3402 Five Chop Rd., Orangeburg, SC 29115 +1-888-389-4485 ~14.02 miles west of Santee
  • Cheap Highway property
  • 2 floors in property
From$60
Average 3.0 /5 Review Score Call BookMore Details
Peach Tree Inn
+1-888-389-4121
111 Conners Dr., Saint George, SC 29477 +1-888-389-4121 ~15.50 miles south of Santee
  • 3-star Highway hotel
  • Hotel has 2 floors
From$80
Average 3.0 /5 Review Score Call BookMore Details
Palmetto Inn by Magnuson Worldwide : 6137 Alex Harvin Highway
+1-888-675-2083
6137 Alex Harvin Highway, Manning, SC 29102 +1-888-675-2083 ~16.15 miles northeast of Santee
  • Economical property
  • Check-in time: 13:00
Sunset Inn Manning in Manning
+1-800-716-8490
5932 Alex Highway, Manning, SC 29102 +1-800-716-8490 ~16.27 miles northeast of Santee
  • Two star property
From$50
Not Good 1.0 /5 Latest Reviews Call BookMore Details
Oyo Hotel Manning Sc : 5342 Alex Harvin Highway
+1-800-805-5223
5342 Alex Harvin Highway, Manning, SC 29102 +1-800-805-5223 ~16.86 miles northeast of Santee
  • Mid-scale hotel
  • 20 rooms in property
From$90
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Hampton Inn Manning in Manning
+1-888-965-1860
2822 Paxville Highway, Manning, SC 29102 +1-888-965-1860 ~19.30 miles northeast of Santee
  • 3-star Highway property
  • Comp. Breakfast
From$90
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Fairfield Inn by Marriott Orangeburg in Orangeburg
+1-888-788-5576
663 Citadel Rd., Orangeburg, SC 29118 +1-888-788-5576 ~20.26 miles west of Santee
  • 3 star Highway property
  • Gym / Fitness Center Available
From$104
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Springhill Stes Orang Marriott in Orangeburg
+1-888-897-9207
675 Citadel Rd., Orangeburg, SC 29118 +1-888-897-9207 ~20.33 miles west of Santee
  • 3 star property
  • Check-in: 15:00
From$90
Average 3.0 /5 Guest Reviews Call BookMore Details
Country Inn & Suites by Radisson, Orangeburg, SC
+1-888-311-4278
731 Citadel Rd., Orangeburg, SC 29118 +1-888-311-4278 ~20.37 miles west of Santee
  • Mid-scale Highway property
  • 4 floors in property
From$103
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Baymont by Wyndham Manning
+1-888-469-4795
2284 Raccoon Rd., Manning, SC 29102 +1-888-469-4795 ~20.37 miles northeast of Santee
  • Mid-scale Rural hotel
  • Free comp. breakfast
From$80
Average 3.0 /5 Hotel Reviews Call BookMore Details
Comfort Inn & Suites
+1-888-734-9421
746 Citadel Rd., Orangeburg, SC 29118 Website +1-888-734-9421 ~20.37 miles west of Santee
  • Economy Rural property
  • Gym is available on property
From$90
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Quality Inn Manning I-95 in Manning
+1-888-841-5292
3031 Paxville Highway, Manning, FL 29102 +1-888-841-5292 ~20.37 miles northeast of Santee
  • Low-priced Highway property
  • Free breakfast
From$65
Average 3.0 /5 Guest Reviews Call BookMore Details
TRU by Hilton Orangeburg Sc in Orangeburg
+1-888-455-5160
739 Citadel Rd., Orangeburg, SC 29118 +1-888-455-5160 ~20.40 miles west of Santee
  • Three Star hotel
  • Check-in time: 15:00
From$90
Very Good 4.5 /5 Review Score Call BookMore Details
Hampton Inn & Suites Orangeburg
+1-888-965-8297
749 Citadel Rd., Orangeburg, SC 29118 +1-888-965-8297 ~20.42 miles west of Santee
  • 3-star Highway property
  • Check-in: 3:00pm
From$119
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Days Inn by Wyndham Manning in Manning
+1-888-906-6358
2825 Paxville Highway, Manning, SC 29102 +1-888-906-6358 ~20.47 miles northeast of Santee
  • Low-priced hotel
  • 2 floors in property
Southern Lodge
+1-888-749-6785
3616 St. Matthews Rd., Orangeburg, SC 29118 +1-888-749-6785 ~20.48 miles west of Santee
  • Economy Highway property
  • 43 rooms in hotel
From$49
Average 3.0 /5 Hotel Reviews Call BookMore Details
Travelodge by Wyndham Orangeburg in Orangeburg
+1-888-878-9982
3620 St. Matthews Rd., Orangeburg, SC 29118 +1-888-878-9982 ~20.48 miles west of Santee
  • Inexpensive Highway property
  • 44 rooms in property
From$50
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Super 8 by Wyndham Manning : 1062 Crossroads Church Rd.
+1-888-389-4485
1062 Crossroads Church Rd., Manning, SC 29102 +1-888-389-4485 ~20.48 miles northeast of Santee
  • Inexpensive Highway hotel
  • Free breakfast available
From$55
Average 3.0 /5 Review Score Call BookMore Details
Super 8 by Wyndham, Orangeburg in Orangeburg
+1-888-389-4121
3608 St. Matthews Rd., Orangeburg, SC 29118 +1-888-389-4121 ~20.49 miles west of Santee
  • Two star Highway property
  • 2 floors in hotel
From$60
Average 3.0 /5 Read Reviews Call BookMore Details
Quality Inn & Suites
+1-888-675-2083
3671 St. Matthews, Orangeburg, SC 29118 +1-888-675-2083 ~20.51 miles west of Santee
  • Inexpensive Rural property
  • Comp. Breakfast
From$66
Average 3.0 /5 Hotel Reviews Call BookMore Details
Holiday Inn Express Hotel & Suites Orangeburg, an IHG Hotel
+1-800-716-8490
118 Sleep Inn Rd., Orangeburg, SC 29118 +1-800-716-8490 ~20.51 miles west of Santee
  • Affordable Rural property
  • 3 floors in property
From$105
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Sleep Inn
+1-800-805-5223
3689 St. Matthews Rd., Orangeburg, SC 29118 +1-800-805-5223 ~20.53 miles west of Santee
  • Low Cost Suburban property
  • Check-in time: 11:00
From$60
Average 3.5 /5 Reviews Call BookMore Details
Days Inn by Wyndham Orangeburg in Orangeburg
+1-888-965-1860
3691 St. Matthews Rd., Orangeburg, SC 29118 +1-888-965-1860 ~20.56 miles west of Santee
  • Low priced Highway hotel
  • Free complimentary breakfast
SureStay by Best Western Manning
+1-888-788-5576
2816 Paxville Highway, Manning, SC 29102 +1-888-788-5576 ~20.58 miles northeast of Santee
  • Midscale Highway property
  • 44 rooms in hotel
From$74
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Baymont by Wyndham Orangeburg North
+1-888-897-9207
3583 Saint Matthews Rd., Orangeburg, SC 29118 +1-888-897-9207 ~20.61 miles west of Santee
  • Low priced Highway hotel
  • 68 sleeping rooms in hotel
From$58
Average 3.0 /5 Latest Reviews Call BookMore Details
Red Roof St. George
+1-888-311-4278
133 Winningham Rd., St George, SC 29477 +1-888-311-4278 ~21.10 miles south of Santee
  • Cheap hotel
  • Check in time: 15:00
From$60
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Quality Inn St George I-95 in Saint George
+1-888-469-4795
6014 West Jim Bilton Blvd., Saint George, SC 29477 +1-888-469-4795 ~21.11 miles south of Santee
  • Mid-scale Rural property
  • Hotel has an eco-friendly policy Learn more
Econo Lodge St George - St. George
+1-888-734-9421
5971 West Jim Bilton Blvd., St. George, SC 29477 +1-888-734-9421 ~21.12 miles south of Santee
  • Economical Highway property
  • 67 rooms in property
From$40
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Knights Inn Saint George
+1-888-841-5292
114 Winningham Rd., Saint George Sc, SC 29477 +1-888-841-5292 ~21.17 miles south of Santee
  • Cheap hotel
  • 2 floors in hotel
From$39
Poor 2.0 /5 Reviews Call BookMore Details
Elite Inn in Walterboro
+1-888-455-5160
115 Winningham Rd., Walterboro, SC 29477 +1-888-455-5160 ~21.17 miles south of Santee
  • Low Cost Downtown hotel
  • Check-in time: 3.00pm
From$55
Very Good 4.0 /5 Read Reviews Call BookMore Details
Days Inn by Wyndham St George in St. George
+1-888-965-8297
139 Frontage Rd., St. George, SC 29477 +1-888-965-8297 ~21.21 miles south of Santee
  • Economical property
  • 103 sleeping rooms in hotel
From$66
Average 3.0 /5 Review Score Call BookMore Details
Americas Best Value Inn St. George, SC in St. George
+1-888-906-6358
125 Motel Dr., St. George, SC 29477 +1-888-906-6358 ~21.23 miles south of Santee
  • Low Cost hotel
  • Hotel has 2 floors
From$60
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Days Inn by Wyndham St George
+1-888-749-6785
139 Motel Dr., St George, SC 29477 +1-888-749-6785 ~21.26 miles south of Santee
  • Two-star hotel
From$60
Average 3.0 /5 Reviews Call BookMore Details
Country Hearth Inn & Suites Saint George
+1-888-878-9982
104 Interstate Dr., Saint George, SC 29477 +1-888-878-9982 ~21.35 miles south of Santee
  • Low-priced property
From$60
Very Good 4.0 /5 Recent Reviews Call BookMore Details

Next: See My Santee Hotels with Pricing

When Is the Best Time to Visit Santee, SC?

With mild weather throughout the majority of the year, there isn't a bad time to visit Santee, South Carolina. For those who like to avoid the heat, the hot season falls between late May and early September. Highs in the 90s are normal in July with an average temperature of 84 degrees throughout most of the summer. The cool season offers a daily high temperature of 64 degrees, which shows that you can golf, hike, bike, and enjoy the outdoors all year round in Santee, South Carolina.

Which Hotels Offer the Best Discount Rates?

Most hotels offer a variety of discounts, including AAA member, Senior discounts, Military and Government rates, and deals for business travelers who stay frequently.

The Comfort Inn & Suites Santee offers a variety of discount options with additional benefits like free cancellation, free breakfast, and eligibility to double up on brand reward programs. A stay at the Comfort Inn & Suites Santee puts you in the heart of the action. Visit Lake Marion, Santee Cooper Country Club, and the Santee National Golf Club.

The air-conditioned rooms include refrigerators, plasma televisions, satellite television, free Wi-Fi, microwaves, and coffee/tea makers. The hotel offers a seasonal outdoor pool, a fireplace in the lobby, free RV, bus, and truck parking, breakfast service, electric car charging station, and is pet-friendly access.

Which Hotels Are Pet-Friendly?

Traveling with your fur family? Santee, South Carolina, offers multiple hotel options that are pet-friendly. Hotel Santee SC Lake Marion, Quality Inn & Suites Santee I 95, and Super 8 by Wyndham Santee are just a few options that welcome your pets.

Hotel Santee SC Lake Marion is a five-minute drive to Lake Marion and Santee Cooper Country Club. The rooms offer air-conditioning, microwaves, flat-screen televisions, and cable television. Guests should contact the property directly to let them know that pet accommodations are required.

Quality Inn & Suites Santee I-95 is a five-minute drive to Lake Marion, Santee Cooper Country Club, and right down the road from the Santee State Park and the Santee National Golf Club. The hotel offers an outdoor pool, picnic area, RV, bus, and truck parking, a restaurant, and free breakfast. The rooms offer air conditioning, free Wi-Fi, cable, microwave, refrigerator, and coffee/tea makers. Contact the hotel property to let them know if a pet is part of your reservation.

Super 8 by Wyndham Santee is located only a few minutes from Santee State Park and 1.6 miles from Santee National Golf Club. The rooms are air-conditioned and outfitted with 40-inch flat-screen televisions with satellite programming, complimentary Wi-Fi, hair dryers, desks, and complimentary toiletries. The hotel has an outdoor pool, free parking, free breakfast, and much more. Contact the property directly if you plan to bring your pet.

Why Stay In Santee, SC?

With a variety of affordable hotel options, Santee, South Carolina, is the perfect place to enjoy the fresh air as part of a weekend family getaway, a golf outing with business partners, or while escaping into the great outdoors.

As the largest lake in South Carolina, Lake Marion covers five counties and has 315 miles of shoreline. Referred to as South Carolina's inland sea, it was dammed in the 1940s under President Franklin D. Roosevelt's New Deal. Visitors describe Lake Marion as a "beautiful, relaxing, and fun place" and "the best bass, catfish, and striper fishing anywhere." The current state fishing record was set at Lake Marion with a 16.2-pound Largemouth Bass. You will also find striped bass, white perch, Arkansas blue catfish, and wildlife including deer, fox, squirrel, alligators, and several duck species.

The Santee National Golf Club provides a challenging 18-hole golf course featuring Bermuda fairways and Champion Bermuda greens. The course includes four lakes, rolling hills, mossy oaks, and a course that will challenge golfers at each hole. Visitors call it "outstanding," "a peach of a course," and "in excellent condition." After your day of golf, unwind at The Grille with their Famous Santee National burger, a BBQ sandwich, or a salad.

For the bird aficionado, head out to the Santee National Wildlife Refuge located on the north shore of Lake Marion. With 13,000 acres of mixed hardwood and pine forests, freshwater marshes, forested wetlands, and open water, Santee National Wildlife Refuge is home to neo-tropical migratory birds, raptors, shorebirds, and wading birds. All of this adds up to 296 bird species for you to view. Visitors describe the refuge as "peaceful" with "plenty of wildlife to view" and someone even saw a "gator...about 12 feet long."

With so much to do and so many excellent options for your stay, it's easy to see why Santee, South Carolina, is a great place to visit.

Recent traveler reviews of Santee, SC

Below are reviews of the city of Santee, SC from an actual visitor's perspective.

"The hotel was comfortable, clean and the staff were very helpful. "
Score 4.0 / 5

The hotel was comfortable, clean and the staff were very helpful. I love Santee because there are plenty of stores and other businesses around.

Vernideen M., from 04-Jul-2023
"Nice Dining Choices"
Score 5.0 / 5

There were some nice choices for dining. A quaint little city.

Linda S., from 06-May-2023
"The staff was friendly and welcoming. Hotel was very clean."
Score 4.0 / 5

The staff was friendly and welcoming. Hotel was very clean. Really enjoyed drinks and dinner at Clark's Inn. The staff & service was great, the food terrific and a wonderful gift shop to browse through.

Perry S., from 01-May-2023
"Nice Little Town"
Score 4.0 / 5

Nice little town. Everything you need was very easily accessible: gas, food, drug store, restaurants.

Beverly M., from 10-Feb-2023
"A good place to visit!"
Score 4.0 / 5

A good place to visit!

Shaqwana Y., from 18-Jan-2023
"Loved the Mexican restaurant across from hotel!"
Score 5.0 / 5

Loved the Mexican restaurant across the street from hotel. Delicious and such friendly people working there!

Julie L., from 23-Aug-2022
"Room was comfortable and clean."
Score 5.0 / 5

You have a lot of eating places to choose from

Chnita D., from 14-Jun-2022
"10 OUT OF 10!"
Score 5.0 / 5

Didn't have the opportunity to see the city of Santee but the hotel is definitely a 10 out of 10!

Sonia L., from 08-Jan-2022
"Safe area."
Score 5.0 / 5

Safe area.

Wendy M., from 20-Dec-2021
"Safe area."
Score 4.0 / 5

Safe area.

Wendy M., from 20-Dec-2021
"Charming!"
Score 5.0 / 5

Pleasant and charming, wished we had more time to explore.

Zoran A., from 28-Nov-2021
"Helpful Staff"
Score 5.0 / 5

Great restaurant referral from Jennifer.

Diane H., from 23-Oct-2021
"Nice & Pleasant"
Score 4.0 / 5

It was so nice and pleasant.

Marvin G., from 19-Oct-2021
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