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Santee South Carolina Accommodations

Find the perfect hotel in Santee using our hotel guide provided below. Search for the cheapest discounted hotel and motel rates in or near Santee, SC for your upcoming personal or group trip. Discover the most favored Santee South Carolina hotel/motel rooms. Review the Santee hotel list below to find the perfect lodging. We also have a map of the Santee hotels. Coordinating a group? Get Santee Group Hotel Discounts

The Santee center point is around 2 miles west of Lake Marion Resort and Marina and 18 miles east of Edisto Memorial Gardens.

"What Is There to See in Santee, SC?"

Southern hospitality abounds in Santee, South Carolina. Located conveniently off Interstate 95, this small town of just under 1000 people hosts 100,000 visitors each year. Lake Marion, Santee State Park, Santee National Golf Club, and the Santee National Wildlife Refuge offer year-round golf, hiking, fishing, water sports, and birding. With so much to do in all seasons, Santee is ideal for outdoor enthusiasts looking to explore the great outdoors. More from this guide...

Santee Hotels/Motels & Accommodations

Holiday Inn Santee
+1-888-389-4121
139 Bradford Blvd., Santee, SC 29142
  • Midscale Highway property
  • Check in: 3.00pm
Oyo Hotel Santee Sc Lake Mario
+1-888-675-2083
628 Bass Dr., Charleston, SC 29142 ~0.30 miles northeast of Santee
  • Three Star hotel
  • 40 rooms in property
Comfort Inn & Suites
+1-800-716-8490
221 Britain St., Santee, SC 29142
  • 2 star Lake property
  • Check-in time: 3:00 PM
Red Roof Inn in Santee
+1-800-805-5223
9091 Old No 6 Highway, Santee, SC 29142
  • Economical Golf Course hotel
  • Check in time: 1.00
Quality Inn & Suites - Santee
+1-888-965-1860
8929 Bass Dr., Santee, SC 29142
  • Two star Golf Course hotel
  • 2 floors in property
Knights Inn Santee in Santee
+1-888-788-5576
249 Britain St., Santee, SC 29142
  • Low-priced Highway property
  • 2 floors in property
Clarion Inn Santee I 95
+1-888-897-9207
123 Mall St., Santee, SC 29142 Website
  • Low-priced Highway property
  • Check-in: 11:00
  • Bathroom needs cleaning
  • Could use a good cleaning
Hampton Inn Santee I 95 : 9060 Old #6 Highway
+1-888-311-4278
9060 Old #6 Highway, Santee, SC 29142
  • Mid-scale Highway hotel
  • Hotel has 81 rooms
  • Generally very clean
  • Clean everything
Fairfield Inn & Suites by Marriott
+1-888-469-4795
9074 Old Highway Number Six Highway, Santee, SC 29142
  • 3-star Highway property
  • Check-in: 3:00 pm
Best Western Plus Santee Inn - Santee
+1-888-734-9421
I 95 Exit 98, Santee, SC 29142
  • Cheap hotel
  • 102 rooms in hotel
Econo Lodge : 9112 Old Number 6 Highway
+1-888-841-5292
9112 Old Number 6 Highway, Santee, SC 29142
  • Cheap Highway hotel
  • 37 rooms in hotel
  • Ridiculously small coffee pot
  • Almost all guests said the bathroom was dirty
Rodeway Inn - Santee
+1-888-455-5160
9117 Old Number 6 Highway, Santee, SC 29142
  • Low-priced Highway hotel
  • Check-in: 11:00
Super 8 by Wyndham Santee
+1-888-965-8297
9125 Old Highway 6, Santee, SC 29142
  • Two-star Highway hotel
  • Check-in: 2pm
Wyndham Vacation Resorts Lake Mario
+1-888-906-6358
401 Bass Dr., Santee, SC 29412
  • Mid-scale hotel
  • Check-in time: 16:00
Days Inn Summerton
+1-888-749-6785
400 Buff Blvd., Summerton, SC 29148 ~10.34 miles northeast of Santee
  • Low priced hotel
Americas Best Value Inn - Columbia
+1-888-878-9982
401 Buff Blvd., Columbia, SC 29148 ~11.09 miles northeast of Santee
  • Economy hotel
  • 80 sleeping rooms in hotel
Days Inn Orangeburg South - Orangeburg
+1-888-389-4485
3402 Five Chop Rd., Orangeburg, SC 29115 ~14.02 miles west of Santee
  • Inexpensive Highway property
  • Hotel has 95 rooms
Peach Tree Inn
+1-888-389-4121
111 Conners Dr., Saint George, SC 29477 ~15.50 miles south of Santee
  • Midscale Highway property
  • Free complimentary breakfast
Knights Inn Manning Sc - Manning
+1-888-675-2083
6137 Alex Harvin Highway, Manning, SC 29102 ~16.15 miles northeast of Santee
  • Cheap property
  • 2 floors in hotel
Sunset Inn Manning : 5932 Alex Highway
+1-800-716-8490
5932 Alex Highway, Manning, SC 29102 ~16.27 miles northeast of Santee
  • Inexpensive hotel
Oyo Hotel Manning Sc
+1-800-805-5223
5342 Alex Harvin Highway, Manning, SC 29102 ~16.86 miles northeast of Santee
  • Three Star property
  • Hotel has 20 rooms
Hampton Inn : 2822 Paxville Highway
+1-888-965-1860
2822 Paxville Highway, Manning, SC 29102 ~19.30 miles northeast of Santee
  • Mid-scale Highway hotel
  • Check in: 2:00pm
Quality Inn : 3031 Paxville Highway
+1-888-788-5576
3031 Paxville Highway, Manning, SC 29102 ~19.32 miles northeast of Santee
  • Economy Golf Course property
  • 2 floors in hotel
  • Terrific location
  • Room needs to be redecorated
Fairfield Inn Orangeburg in Orangeburg
+1-888-897-9207
663 Citadel Rd., Orangeburg, SC 29118 ~20.26 miles west of Santee
  • Mid-scale Highway property
  • Check-in time: 3:00 PM
  • Beds were comfortable
  • Most guests found the staff to be very friendly
Springhill Stes Orang Marriott - Orangeburg
+1-888-311-4278
675 Citadel Rd., Orangeburg, SC 29118 ~20.33 miles west of Santee
  • 3-star property
  • Check in time: 15:00
Next 25 Santee Hotels >  [1 - 25 of 50]    
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Bar Chart: Upcoming 20 Days of Santee Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Santee, SC discounts available. The chart reflects the cheapest Santee hotel for each day and each star rating category.

Lake Marion is a must-see when traveling through Santee, South Carolina. Boasting 110,000 acres, it is listed as one of the fifty largest lakes in the country, and it is known for its trophy catfish and impressive striped bass population. Not an angler? Lake Marion is part of Santee State Park, which offers hiking, biking, playgrounds, and the chance to sit back and enjoy the view from your lakeside cabin rental. Love to Golf? Then visit the Santee National Golf Club where you can enjoy the lush greens, lakes, and challenging 18-hole course.

There is something for everyone in this delightful stop along Interstate 95 in South Carolina.

When Is the Best Time to Visit Santee, SC?

With mild weather throughout the majority of the year, there isn't a bad time to visit Santee, South Carolina. For those who like to avoid the heat, the hot season falls between late May and early September. Highs in the 90s are normal in July with an average temperature of 84 degrees throughout most of the summer. The cool season offers a daily high temperature of 64 degrees, which shows that you can golf, hike, bike, and enjoy the outdoors all year round in Santee, South Carolina.

Below is a chart of the current pricing seasonality of hotels and motels in Santee, SC:

seasonality of hotel rates in Santee

Averate Rates by Star Rating

Below are 3 charts displaying average nightly cost trends by star rating class in Santee, SC. Analyze these charts to calculate the cheapest seasons to stay in Santee for your upcoming travels.

What Luxury Hotels Are in Santee, SC?

If you are looking for luxury hotel options in Santee, South Carolina, there are two great options available to you. Both are incredibly close to Interstate 95 and all that Santee, South Carolina, has to offer.

First, the Hampton Inn Santee I-95 is just off Interstate 95 and boasts very high guest ratings and a long list of amenities including free Wi-Fi, free breakfast, free self-parking including RV, bus, and truck parking, laundry facilities, fitness center, outdoor pool, and a 100% smoke-free property. The business traveler will find a 24-hour business center, complimentary newspapers, and dry cleaning services. The rooms include flat-screen televisions, refrigerators, free wired and wireless internet, safes, desks, and daily housekeeping.

The Hampton Inn Santee-I-95 offers a variety of room options including a king bed, king study sofa bed, king mobility hearing accessible with roll-in shower, queen bed, double queen bed, and suites. If you are hosting an event in Santee, South Carolina, this hotel has a meeting room and facilities measuring 576 square feet (52 square meters) available.

Hotel guests describe the staff at Hampton Inn Santee I-95 as efficient and cheerful and the hotel as the "best value for money" in the area.

Next, the Fairfield Inn & Suites by Marriott Santee is another great option. Within only a five-minute drive of Lake Marion, Santee Cooper Country Club, and the Santee State Park, this hotel offers easy access to all activities. The rooms include refrigerators, microwaves, private patios, 55-inch flat-screen televisions with satellite programming, free Wi-Fi, coffee/tea makers, and sofa beds.

The hotel offers a wide range of amenities including 24-hour fitness facilities, barbecue grills, free breakfast that includes eggs, sausage, oatmeal, mini-waffles, and more. Plus, the hotel also offers free RV, bus, and truck parking, laundry facilities, indoor and outdoor pools, a picnic area, smoke-free property, and a snack bar/deli.

If you are hosting an event, the Fairfield Inn & Suites by Marriott Santee offers wedding services, a meeting room, and 975 square feet (91 square meters) of space.

Hotel guests describe the Fairfield Inn & Suites by Marriott Santee as a "new home away from home."

What Affordable Options Are Available in Santee, SC?

3 Star Average Prices: $120.79

Low-cost hotel options in Santee, South Carolina are easy to find, even during peak travel times.
Located in the Santee, South Carolina, city center, Best Western Plus Santee Inn offers clean, comfortable rooms with refrigerators and microwaves, complimentary Wi-Fi, free breakfast, and fitness facilities. When you aren't out exploring, you can rest by the outdoor pool. The Best Western Santee Inn offers you a restaurant onsite. Free parking, laundry facilities, and a business center are available.

The Econo Lodge, centrally located in Santee, offers free continental breakfast, free self-parking including RV, bus, and truck parking, a garden, and barbecue grills for guest use. The rooms include refrigerators, microwaves, air-conditioning, cable, coffee/tea makers, and irons/ironing boards. You can also enjoy free high-speed internet and premium movie channels.

3 Star Hotel Prices in Santee

2 Star Average Prices: $71.15

2 Star Hotel Prices in Santee

Which Hotels Offer the Best Discount Rates?

Most hotels offer a variety of discounts, including AAA member, Senior discounts, Military and Government rates, and deals for business travelers who stay frequently.

The Comfort Inn & Suites Santee offers a variety of discount options with additional benefits like free cancellation, free breakfast, and eligibility to double up on brand reward programs. A stay at the Comfort Inn & Suites Santee puts you in the heart of the action. Visit Lake Marion, Santee Cooper Country Club, and the Santee National Golf Club.

The air-conditioned rooms include refrigerators, plasma televisions, satellite television, free Wi-Fi, microwaves, and coffee/tea makers. The hotel offers a seasonal outdoor pool, a fireplace in the lobby, free RV, bus, and truck parking, breakfast service, electric car charging station, and is pet-friendly access.

Which Hotels Are Pet-Friendly?

Traveling with your fur family? Santee, South Carolina, offers multiple hotel options that are pet-friendly. Hotel Santee SC Lake Marion, Quality Inn & Suites Santee I 95, and Super 8 by Wyndham Santee are just a few options that welcome your pets.

Hotel Santee SC Lake Marion is a five-minute drive to Lake Marion and Santee Cooper Country Club. The rooms offer air-conditioning, microwaves, flat-screen televisions, and cable television. Guests should contact the property directly to let them know that pet accommodations are required.

Quality Inn & Suites Santee I-95 is a five-minute drive to Lake Marion, Santee Cooper Country Club, and right down the road from the Santee State Park and the Santee National Golf Club. The hotel offers an outdoor pool, picnic area, RV, bus, and truck parking, a restaurant, and free breakfast. The rooms offer air conditioning, free Wi-Fi, cable, microwave, refrigerator, and coffee/tea makers. Contact the hotel property to let them know if a pet is part of your reservation.

Super 8 by Wyndham Santee is located only a few minutes from Santee State Park and 1.6 miles from Santee National Golf Club. The rooms are air-conditioned and outfitted with 40-inch flat-screen televisions with satellite programming, complimentary Wi-Fi, hair dryers, desks, and complimentary toiletries. The hotel has an outdoor pool, free parking, free breakfast, and much more. Contact the property directly if you plan to bring your pet.

Why Stay In Santee, SC?

With a variety of affordable hotel options, Santee, South Carolina, is the perfect place to enjoy the fresh air as part of a weekend family getaway, a golf outing with business partners, or while escaping into the great outdoors.

As the largest lake in South Carolina, Lake Marion covers five counties and has 315 miles of shoreline. Referred to as South Carolina's inland sea, it was dammed in the 1940s under President Franklin D. Roosevelt's New Deal. Visitors describe Lake Marion as a "beautiful, relaxing, and fun place" and "the best bass, catfish, and striper fishing anywhere." The current state fishing record was set at Lake Marion with a 16.2-pound Largemouth Bass. You will also find striped bass, white perch, Arkansas blue catfish, and wildlife including deer, fox, squirrel, alligators, and several duck species.

The Santee National Golf Club provides a challenging 18-hole golf course featuring Bermuda fairways and Champion Bermuda greens. The course includes four lakes, rolling hills, mossy oaks, and a course that will challenge golfers at each hole. Visitors call it "outstanding," "a peach of a course," and "in excellent condition." After your day of golf, unwind at The Grille with their Famous Santee National burger, a BBQ sandwich, or a salad.

For the bird aficionado, head out to the Santee National Wildlife Refuge located on the north shore of Lake Marion. With 13,000 acres of mixed hardwood and pine forests, freshwater marshes, forested wetlands, and open water, Santee National Wildlife Refuge is home to neo-tropical migratory birds, raptors, shorebirds, and wading birds. All of this adds up to 296 bird species for you to view. Visitors describe the refuge as "peaceful" with "plenty of wildlife to view" and someone even saw a "gator...about 12 feet long."

With so much to do and so many excellent options for your stay, it's easy to see why Santee, South Carolina, is a great place to visit.

FAQs about hotels in Santee

What are the most favored hotels in Santee?

Fairfield Inn & Suites by Marriott, Hampton Inn Santee I 95 and Best Western Plus Santee Inn are the best rated hotels based on customer reviews in the last 365 days.

What are the 4-5 star hotels in Santee?

Holiday Inn Santee, Oyo Hotel Santee Sc Lake Mario and Hampton Inn Santee I 95 are the top 3 luxury hotels near Santee city center.

What hotels are closest to the city center of Santee?

Holiday Inn Santee, Oyo Hotel Santee Sc Lake Mario, and Comfort Inn & Suites are the properties closest to Santee city center.

How much does a cheap hotel in Santee cost per night?

In the last year, a 2 star hotel in Santee can be as cheap as $71.15 per night. (based on HotelPlanner prices)

How much does a 3 star hotel in Santee cost per night?

In the last year, the average 3 star hotel in Santee has been $120.79 per night. (based on HotelPlanner prices)

What are the best independent hotels in Santee?

Country Inns & Suites Orangeburg, Southern Lodge and Sunset Inn Manning are the best rated independent hotels (not part of a big brand).

What are the best Marriott hotels in Santee?

Fairfield Inn & Suites by Marriott, Fairfield Inn Orangeburg and Springhill Stes Orang Marriott are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the most popular Choice Hotels branded hotels in Santee?

Comfort Inn & Suites, Quality Inn and Comfort Inn & Suites are the best rated Choice Hotels branded hotels (based on HotelPlanner reviews score).

What are the best Best Western hotels in Santee?

Best Western Plus Santee Inn and SureStay Hotel by Best Western Manning are the best rated Best Western branded hotels (based on user reviews score).

What are the best IHG hotels in Santee?

Holiday Inn Santee and Holiday Inn Express & Suites of Orangeburg are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

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