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Cairo Illinois Accommodations

Find hotels & motels in Cairo using the list below. Search for cheap and discounted hotel and motel rates in or close to Cairo, IL for your upcoming individual or group travel. Discover the best Cairo Illinois hotel/motel rooms. Review the Cairo hotel list below to find the perfect lodging. We also have a map of the Cairo hotels.

Cairo Hotels, Motels & Accommodations

Quality Inn Cairo I-57 : 13201 Kessler Rd. 13201 Kessler Rd., Cairo, IL 62914
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  • Three Star Highway hotel
  • Check-in time: 3 pm
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From£53 total
Poor 2.0 /5 Read Reviews Call BookMore Details
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Super 8 by Wyndham Charleston/Sikeston East MO - Charleston 310 South Story, Charleston, MO 63834
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~10.13 miles southwest of Cairo
  • 2-star Highway hotel
  • 7 suites in property
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From£37 total
Average 3.5 /5 Recent Reviews Call BookMore Details
The Riverstone Hotel Charleston-Sikeston in Charleston 102 Drake St., Charleston, MO 63834
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~11.88 miles southwest of Cairo
  • Two-star Highway hotel
  • Check-in time: 3:00PM
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From£52 total
Average 3.0 /5 Reviews Call BookMore Details
Americas Best Value Inn Ullin Mounds - Ullin 128 Cheekwood Lane, Ullin, IL 62992
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~17.88 miles north of Cairo
  • Inexpensive hotel
  • Free breakfast
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From£53 total
Average 3.0 /5 Hotel Reviews Call BookMore Details
Motel 6 Sikeston Mo 110 South Interstate Dr., SIKESTON, MO 63801
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~20.96 miles west of Cairo
  • Inexpensive property
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From£53 total
Average 3.0 /5 Guest Reviews Call BookMore Details
Best Western Plus Sikeston in Sikeston 120 South Interstate Dr., Sikeston, MO 63801
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~21.00 miles west of Cairo
  • Two star Highway hotel
  • Hotel has 2 floors
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From£37 total
Very good 4.0 /5 Read Reviews Call BookMore Details
Days Inn and Suites by Wyndham Sikeston - Sikeston 220 South Interstate Dr., Sikeston, MO 63801
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~21.07 miles west of Cairo
  • 2-star hotel
  • Access to gym on-site
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From£53 total
Average 3.0 /5 Read Reviews Call BookMore Details
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) - Sikeston 100 Matthews Lane, Sikeston, MO 63801
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~21.31 miles west of Cairo
  • 3-star Highway hotel
  • Free breakfast available
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From£70 total
Very good 4.0 /5 Review Score Call BookMore Details
Super 8 by Wyndham Sikeston/Miner Area : 2609 East Malone 2609 East Malone, Sikeston, MO 63801
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~21.32 miles west of Cairo
  • Two-star Convention Center property
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From£53 total
Average 3.0 /5 Reviews Call BookMore Details
Comfort Inn - Sikeston 109 Matthews Lane, Sikeston, MO 63801
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~21.34 miles west of Cairo
  • 3 star Highway hotel
  • Hotel has 64 rooms
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From£75 total
Average 3.0 /5 Guest Reviews Call BookMore Details
Hampton Inn Sikeston 1240 Commerce Dr., Sikeston, MO 63801
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~24.48 miles west of Cairo
  • Midscale Rural property
  • Fitness center on property
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From£70 total
Average 3.0 /5 Guest Reviews Call BookMore Details
Holiday Inn Express & Suites Sikeston An Ihg Hotel 115 Hospitality Dr., Sikeston, MO 63801
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~24.49 miles west of Cairo
  • Midscale Rural property
  • Fitness + Health Center
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From£70 total
Average 3.0 /5 Read Reviews Call BookMore Details
Residence Inn by Marriott Paducah in Paducah 3900 Coleman Crossing Circle, Paducah, KY 42001
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~25.66 miles east of Cairo
  • 3 star Suburban hotel
  • Hotel has 74 rooms
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From£78 total
Very good 4.0 /5 Reviews Call BookMore Details
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Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destinatio : 100 East Front St. 100 East Front St., Metropolis, IL 62960
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~26.28 miles east of Cairo
  • 4 star property
  • 7 floors in property
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From£141 total
Very good 4.0 /5 Read Reviews Call BookMore Details
Baymont by Wyndham Metropolis : 203 East Front St. 203 East Front St., Metropolis, IL 62960
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~26.32 miles east of Cairo
  • Cheap Riverfront hotel
  • Check-in time: 3:00PM
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From£39 total
Average 3.0 /5 Hotel Reviews Call BookMore Details
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Econo Lodge : 1415 East 5th St. 1415 East 5th St., Metropolis, IL 62960
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~27.38 miles east of Cairo
  • Cheap hotel
  • Hotel has 45 rooms
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From£53 total
Terrible 1.0 /5 Guest Reviews Call BookMore Details
 Econo Lodge Paducah West I-24 in Paducah 5120 Hinkleville Rd., Paducah, KY 42001
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~27.55 miles east of Cairo
  • Inexpensive Airport property
  • Hotel has a green policy Learn more
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From£53 total
Average 3.0 /5 Reviews Call BookMore Details
Baymont by Wyndham Paducah in Paducah 5300 Old Cairo Rd., Paducah, KY 42001
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~27.64 miles east of Cairo
  • Midscale property
  • 3 floors in hotel
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From£35 total
Poor 2.0 /5 Guest Reviews Call BookMore Details
Courtyard by Marriott Cape Girardeau Downtown - Cape Girardeau 400 Broadway St., Cape Girardeau, MO 63701
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~27.65 miles northwest of Cairo
  • Three Star Downtown property
  • 78 rooms in property
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From£70 total
Very good 4.0 /5 Read Reviews Call BookMore Details
Quality Suites Paducah I-24 2880 James Sanders Blvd., Paducah, KY 42001 Website
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~27.73 miles east of Cairo
  • 2-star Highway hotel
  • Check in: 3:00 pm
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From£53 total
Average 3.0 /5 Hotel Reviews Call BookMore Details
Comfort Inn & Suites near Six Flags 960 West Pointe Court, Lithia Springs, GA 30122 Website
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~27.80 miles east of Cairo
  • Affordable Downtown property
  • Complimentary breakfast is offered
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From£61 total
Very good 4.0 /5 Reviews Call BookMore Details
Garner Hotel Paducah West by IHG 145 Mcbride Lane, Paducah, KY 42001
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~27.80 miles east of Cairo
  • 3 star Highway property
  • Check-in time: 3pm
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From£43 total
Very good 4.0 /5 Reviews Call BookMore Details
Hotel 7 Inn Paducah - Paducah 5001 Hinkleville Rd., Paducah, KY 42001
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~27.81 miles east of Cairo
  • Cheap property
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From£53 total
Average 3.0 /5 Recent Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham Paducah in Paducah 3960 Coleman Crossing Cir, Paducah, KY 42001
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~27.90 miles east of Cairo
  • 3 star Highway property
  • Hotel has 26 suites
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From£70 total
Average 3.0 /5 Latest Reviews Call BookMore Details
Candlewood Suites Paducah by IHG 3940 Coleman Crossing Circle, Paducah, KY 42001
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~27.91 miles east of Cairo
  • Affordable Rural property
  • Check-in time: 3:00pm
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From£53 total
Very good 4.0 /5 Reviews Call BookMore Details
Homewood Suites by Hilton Paducah in Paducah 3925 Coleman Crossing Cir, Paducah, KY 42001
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~27.94 miles east of Cairo
  • 3 star Highway hotel
  • 97 suites in property
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From£96 total
Very good 4.0 /5 Reviews Call BookMore Details
Comfort Suites - Paducah 3918 Coleman Crossing Cir Paducah Ky 42001, Paducah, KY 42001
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~27.96 miles east of Cairo
  • Economical Rural property
  • Hotel has 72 suites
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From£53 total
Average 3.0 /5 Recent Reviews Call BookMore Details
Comfort Inn Paducah in Paducah 5135 Cairo Rd., Paducah, KY 42001
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~27.98 miles east of Cairo
  • Mid-scale property
  • Check in: 3:00 PM
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From£52 total
Very good 4.0 /5 Latest Reviews Call BookMore Details
Fairfield Inn & Suites by Marriott Paducah in Paducah 3950 Coleman Crossing Circle, Paducah, KY 42001
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~28.01 miles east of Cairo
  • Midscale Rural hotel
  • 82 rooms in hotel
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From£66 total
Very good 4.0 /5 Reviews Call BookMore Details
Red Roof Inn Paducah - Paducah 5106 Old Cairo Rd., Paducah, KY 42001
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~28.01 miles east of Cairo
  • Low Cost hotel
  • Hotel has 8 suites
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From£39 total
Average 3.5 /5 Read Reviews Call BookMore Details
American Inn 5125 Cairo Rd., Paducah, KY 42001
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~28.02 miles east of Cairo
  • Economical hotel
  • Complimentary breakfast is offered
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From£32 total
Very good 4.0 /5 Reviews Call BookMore Details
Hampton Inn & Suites Paducah 3901 Coleman Crossing Circle, Paducah, KY 42001
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~28.02 miles east of Cairo
  • Midscale Highway property
  • 32 suites in property
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From£69 total
Very good 4.5 /5 Recent Reviews Call BookMore Details
Holiday Inn Express Hotel & Suites Paducah West by IHG 3996 Hinkleville Rd., Paducah, KY 42001
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~28.04 miles east of Cairo
  • Affordable Highway hotel
  • Hotel has 3 floors
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From£70 total
Average 3.0 /5 Hotel Reviews Call BookMore Details
Spark by Hilton 3994 Hinkleville Rd., Paducah, KY 42001
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~28.05 miles east of Cairo
  • Midscale Airport hotel
  • Fitness center on property
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From£70 total
Very good 4.0 /5 Reviews Call BookMore Details
Courtyard by Marriott Paducah 3835 Technology Dr., Paducah, KY 42001
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~28.29 miles east of Cairo
  • Mid-scale Suburban property
  • Access to gym on-site
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From£78 total
Very good 4.0 /5 Guest Reviews Call BookMore Details
Days Inn by Wyndham Paducah I-24 Exit 4 - Paducah 3901 Hinkleville Rd., Paducah, KY 42001
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~28.75 miles east of Cairo
  • Economy Highway hotel
  • Check in time: 11:00 am
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From£44 total
Average 3.0 /5 Guest Reviews Call BookMore Details
Candlewood Suites Cape Girardeau by IHG 485 South Mount Auburn Rd., Cape Girardeau, MO 65703
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~28.76 miles northwest of Cairo
  • Two-star Highway hotel
  • Hotel has 85 rooms
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From£61 total
Very good 4.0 /5 Read Reviews Call BookMore Details
Travelers Inn and Suites : 2550 Lone Oak Rd. 2550 Lone Oak Rd., Paducah, KY 42003
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~28.88 miles east of Cairo
  • 2-star hotel
  • Check-in: 2:00PM
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From£33 total
Very good 4.0 /5 Read Reviews Call BookMore Details
Quality Inn & Suites Metropolis I-24 2118 East 5th St., Metropolis, IL 62960
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~28.88 miles east of Cairo
  • 3-star hotel
  • Check-in time: 11:00
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From£70 total
Very good 4.0 /5 Recent Reviews Call BookMore Details
Super 8 by Wyndham Metropolis 2055 East 5th St., Metropolis, IL 62960
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~28.89 miles east of Cairo
  • Economical Highway hotel
  • 6 suites in property
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From£53 total
Average 3.0 /5 Recent Reviews Call BookMore Details
Motel 6 Metropolis Il 2119 East 5th St., Metropolis, IL 62960
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~29.04 miles east of Cairo
  • Low-priced hotel
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From£53 total
Average 3.0 /5 Latest Reviews Call BookMore Details
Holiday Inn Express Metropolis by IHG 2179 East 5th St., Metropolis, IL 62960
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~29.10 miles east of Cairo
  • 3-star Rural property
  • 21 suites in property
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From£57 total
Very good 4.0 /5 Guest Reviews Call BookMore Details
Hampton Inn Cape Girardeau I 55 East 207 South Mount Auburn Rd., Cape Girardeau, MO 63703
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~29.41 miles northwest of Cairo
  • Affordable Highway property
  • Hotel has 86 rooms
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From£70 total
Excellent 5.0 /5 Latest Reviews Call BookMore Details
Victorian Inn & Suites 3256 William St., Cape Girardeau, MO 63703
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~29.41 miles northwest of Cairo
  • Mid-scale Golf Course hotel
  • Free breakfast available
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From£69 total
Average 3.0 /5 Reviews Call BookMore Details
Auburn Place Hotel & Suites 3265 Williams St., Cape Girardeau, MO 63702
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~29.42 miles northwest of Cairo
  • Midscale Highway property
  • 133 sleeping rooms in hotel
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From£51 total
Very good 4.5 /5 Hotel Reviews Call BookMore Details
Holiday Inn Express & Suites Cape Girardeau I 55 by Ihg : 3253 William St. 3253 William St., Cape Girardeau, MO 63701
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~29.49 miles northwest of Cairo
  • 3 star property
  • 102 suites in property
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From£70 total
Very good 4.5 /5 Review Score Call BookMore Details
Fairfield Inn & Suites Cape Girardeau 433 Cape West Crossing, Cape Girardeay, MO 63703
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~29.58 miles northwest of Cairo
  • 3 star hotel
  • 4 floors in property
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From£70 total
Average 3.0 /5 Review Score Call BookMore Details
Drury Lodge - Cape Girardeau 104 South Vantage Dr., Cape Girardeau, MO 63701
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~29.82 miles northwest of Cairo
  • Mid-scale Highway hotel
  • Free breakfast
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From£70 total
Average 3.0 /5 Reviews Call BookMore Details
Quality Inn Cape Girardeau North in Cape Girardeau 2011 North Kingshighway St., Cape Girardeau, MO 63701 Website
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~31.37 miles northwest of Cairo
  • 2 star hotel
  • Complimentary breakfast is offered
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From£53 total
Very good 4.0 /5 Reviews Call BookMore Details
Hotel 7 Inn Anna 100 Richview Dr., Anna, IL 62906
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~31.39 miles north of Cairo
  • 2-star property
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From£53 total
Very good 4.0 /5 Review Score Call BookMore Details

Next: See My Cairo Hotels with Pricing

Graph: Upcoming 20 Days of Cairo Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Cairo, IL discounts available. The chart reflects the cheapest Cairo hotel for each day and each star rating category.

FAQs about hotels in Cairo

What are the most favored hotels in Cairo?

Hampton Inn Cape Girardeau I 55 East, Hampton Inn & Suites Paducah and Auburn Place Hotel & Suites are the best rated hotels based on customer reviews in the last 365 days.

What are the most luxurious hotels in Cairo?

Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destinatio, Quality Inn Cairo I-57 and Travel Inn & Suites - Sikeston are the top 3 luxury hotels near Cairo city center.

What hotels are closest to the city center of Cairo?

Quality Inn Cairo I-57, Super 8 by Wyndham Charleston, and The Riverstone Hotel Charleston-Sikeston are the properties closest to Cairo city center.

What are the best independent hotels in Cairo?

Auburn Place Hotel & Suites, Travel Inn & Suites - Sikeston and American Inn are the best rated independent hotels (not part of a big brand).

What are the most popular Marriott hotels in Cairo?

Residence Inn by Marriott Paducah, Courtyard by Marriott Cape Girardeau Downtown and Fairfield Inn & Suites by Marriott Paducah are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the best Choice Hotels branded hotels in Cairo?

Comfort Inn & Suites near Six Flags, Comfort Inn Paducah and Quality Inn & Suites Metropolis I-24 are the best rated Choice Hotels branded hotels (based on HotelPlanner reviews score).

What are the best IHG hotels in Cairo?

Holiday Inn Express & Suites Cape Girardeau I 55 by Ihg, Candlewood Suites Paducah by IHG and Candlewood Suites Cape Girardeau by IHG are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

Verified reviews of the city: Cairo, IL

Below are reviews of the city of Cairo, IL from an actual visitor's perspective.

"Spending time with my family"
Score 5.0 / 5

Vincent R., from 26-Jan-2026
The average traveler rating of the city of Cairo, IL shown above is 5.0 out of 5 based on 1 reviews
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