Star rating
Hotel name
Price range (GBP) to
Amenities
+ more

Cairo Illinois Accommodations

Find hotels & motels in Cairo using the list below. Search for cheap and discounted hotel and motel rates in or close to Cairo, IL for your upcoming individual or group travel. Discover the best Cairo Illinois hotel/motel rooms. Review the Cairo hotel list below to find the perfect lodging. We also have a map of the Cairo hotels.

Cairo Hotels, Motels & Accommodations

Quality Inn Cairo I-57 13201 Kessler Rd., Cairo, IL 62914
Call Us
  • Affordable Highway hotel
  • Hotel has 38 rooms
More Photos Photo of Quality Inn Cairo I-57
From£44
Poor 2.0 /5 Recent Reviews Call BookMore Details
Tired of clicking around? Talk to an expert Hotel Planner: (855) 276-7561 or say...
alexa hotel planner skill"Alexa, ask Hotel Planner to make a new reservation in Cairo" Get Alexa Skill →
Super 8 by Wyndham Charleston/Sikeston East MO 310 South Story, Charleston, MO 63834
Call Us
~10.13 miles southwest of Cairo
  • Cheap Highway hotel
  • Check in time: 3:00pm
More Photos Photo of Super 8 by Wyndham Charleston/Sikeston East MO
From£30
Average 3.5 /5 Hotel Reviews Call BookMore Details
Quality Inn Charleston - Sikeston 102 Drake St., Charleston, MO 63834
Call Us
~11.88 miles southwest of Cairo
  • Low Cost Highway hotel
  • 9 suites in property
More Photos Image of Quality Inn Charleston - Sikeston
From£43
Average 3.0 /5 Review Score Call BookMore Details
Americas Best Value Inn Ullin Mounds : 128 Cheekwood Lane 128 Cheekwood Lane, Ullin, IL 62992
Call Us
~17.88 miles north of Cairo
  • Two-star property
  • 40 rooms in hotel
More Photos Photo of Americas Best Value Inn Ullin Mounds
From£44
Average 3.0 /5 Recent Reviews Call BookMore Details
Motel 6 Sikeston Mo 110 South Interstate Dr., SIKESTON, MO 63801
Call Us
~20.96 miles west of Cairo
  • 2-star property
More Photos Image of Motel 6 Sikeston Mo
From£44
Average 3.0 /5 Recent Reviews Call BookMore Details
Best Western Plus Sikeston - Sikeston 120 South Interstate Dr., Sikeston, MO 63801
Call Us
~21.00 miles west of Cairo
  • Economical Highway property
  • 2 floors in hotel
More Photos Photo of Best Western Plus Sikeston
From£31
Very good 4.0 /5 Recent Reviews Call BookMore Details
Days Inn and Suites by Wyndham Sikeston 220 South Interstate Dr., Sikeston, MO 63801
Call Us
~21.07 miles west of Cairo
  • Cheap property
  • Check-in: 03:00 PM
More Photos Photo of Days Inn and Suites by Wyndham Sikeston
From£44
Average 3.0 /5 Review Score Call BookMore Details
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) : 100 Matthews Lane 100 Matthews Lane, Sikeston, MO 63801
Call Us
~21.31 miles west of Cairo
  • 3-star Highway hotel
  • Free complimentary breakfast
More Photos Photo of Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
From£58
Very good 4.0 /5 Guest Reviews Call BookMore Details
Super 8 by Wyndham Sikeston/Miner Area 2609 East Malone, Sikeston, MO 63801
Call Us
~21.32 miles west of Cairo
  • Economy Convention Center hotel
  • Check in: 01:00
More Photos Photo of Super 8 by Wyndham Sikeston/Miner Area
From£44
Average 3.0 /5 Reviews Call BookMore Details
Comfort Inn 109 Matthews Lane, Sikeston, MO 63801
Call Us
~21.34 miles west of Cairo
  • Midscale Highway hotel
More Photos Photo of Comfort Inn
From£62
Average 3.0 /5 Recent Reviews Call BookMore Details
Hampton Inn Sikeston in Sikeston 1240 Commerce Dr., Sikeston, MO 63801
Call Us
~24.48 miles west of Cairo
  • Three Star Rural property
  • Access to gym on-site
More Photos Exterior of Hampton Inn Sikeston
From£58
Average 3.0 /5 Guest Reviews Call BookMore Details
Holiday Inn Express & Suites Sikeston An Ihg Hotel - Sikeston 115 Hospitality Dr., Sikeston, MO 63801
Call Us
~24.49 miles west of Cairo
  • Midscale Rural hotel
  • 73 rooms in property
More Photos Photo of Holiday Inn Express & Suites Sikeston An Ihg Hotel
From£58
Average 3.0 /5 Guest Reviews Call BookMore Details
Residence Inn by Marriott Paducah - Paducah 3900 Coleman Crossing Circle, Paducah, KY 42001
Call Us
~25.66 miles east of Cairo
  • Three Star Suburban property
  • Hotel has 2 meeting rooms
More Photos Exterior of Residence Inn by Marriott Paducah
From£65
Very good 4.0 /5 Reviews Call BookMore Details
More Homes & Apts at Booking.com

Book online or call +44 8081694373

Booking for Homes and Apartments
Go to BookingGo to Booking
Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destinatio in Metropolis 100 East Front St., Metropolis, IL 62960
Call Us
~26.28 miles east of Cairo
  • Four-star hotel
  • 7 floors in property
More Photos Photo of Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destinatio
From£117
Very good 4.0 /5 Review Score Call BookMore Details
Baymont by Wyndham Metropolis 203 East Front St., Metropolis, IL 62960
Call Us
~26.32 miles east of Cairo
  • Cheap Riverfront property
  • Gym is available on property
More Photos Image of Baymont by Wyndham Metropolis
From£33
Average 3.0 /5 Read Reviews Call BookMore Details
Need some questions answered? Talk to an expert Hotel Planner: (855) 276-7561 or say...
alexa hotel planner skill"Alexa, ask Hotel Planner to make a new reservation in Cairo" Get Alexa Skill →
Econo Lodge in Metropolis 1415 East 5th St., Metropolis, IL 62960
Call Us
~27.38 miles east of Cairo
  • Low Cost property
  • 45 rooms in hotel
More Photos Image of Econo Lodge
From£44
Terrible 1.0 /5 Recent Reviews Call BookMore Details
 Econo Lodge Paducah West I-24 - Paducah 5120 Hinkleville Rd., Paducah, KY 42001
Call Us
~27.55 miles east of Cairo
  • Two-star Airport hotel
  • 2 floors in hotel
More Photos Exterior of  Econo Lodge Paducah West I-24
From£44
Average 3.0 /5 Recent Reviews Call BookMore Details
Baymont by Wyndham Paducah - Paducah 5300 Old Cairo Rd., Paducah, KY 42001
Call Us
~27.64 miles east of Cairo
  • Mid-scale hotel
  • Hotel has 3 floors
More Photos Photo of Baymont by Wyndham Paducah
From£29
Poor 2.0 /5 Hotel Reviews Call BookMore Details
Courtyard by Marriott Cape Girardeau Downtown : 400 Broadway St. 400 Broadway St., Cape Girardeau, MO 63701
Call Us
~27.65 miles northwest of Cairo
  • Mid-scale Downtown hotel
  • Gym is available on property
More Photos Exterior of Courtyard by Marriott Cape Girardeau Downtown
From£58
Very good 4.0 /5 Reviews Call BookMore Details
Drury Suites Paducah 2930 James Sanders Blvd., Paducah, KY 42001
Call Us
~27.70 miles east of Cairo
  • 3 star Suburban property
  • 138 rooms in property
More Photos Exterior of Drury Suites Paducah
From£72
Very good 4.0 /5 Read Reviews Call BookMore Details
Quality Suites Paducah I-24 : 2880 James Sanders Blvd. 2880 James Sanders Blvd., Paducah, KY 42001 Website
Call Us
~27.73 miles east of Cairo
  • Inexpensive Highway hotel
  • 59 rooms in hotel
More Photos Photo of Quality Suites Paducah I-24
From£44
Average 3.0 /5 Read Reviews Call BookMore Details
Comfort Inn & Suites near Six Flags - Lithia Springs 960 West Pointe Court, Lithia Springs, GA 30122 Website
Call Us
~27.80 miles east of Cairo
  • Three Star Downtown hotel
  • 2 floors in property
More Photos Exterior of Comfort Inn & Suites near Six Flags
From£51
Very good 4.0 /5 Recent Reviews Call BookMore Details
Garner Hotel Paducah West by IHG - Paducah 145 Mcbride Lane, Paducah, KY 42001
Call Us
~27.80 miles east of Cairo
  • Affordable Highway hotel
  • Fitness + Health Center
More Photos Photo of Garner Hotel Paducah West by IHG
From£35
Very good 4.0 /5 Review Score Call BookMore Details
Hotel 7 Inn Paducah 5001 Hinkleville Rd., Paducah, KY 42001
Call Us
~27.81 miles east of Cairo
  • Cheap property
More Photos Image of Hotel 7 Inn Paducah
From£44
Average 3.0 /5 Guest Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham Paducah 3960 Coleman Crossing Cir, Paducah, KY 42001
Call Us
~27.90 miles east of Cairo
  • Mid-scale Highway property
  • Hotel has an eco-friendly policy See more
More Photos Photo of La Quinta Inn & Suites by Wyndham Paducah
From£58
Average 3.0 /5 Guest Reviews Call BookMore Details
Candlewood Suites Paducah by IHG : 3940 Coleman Crossing Circle 3940 Coleman Crossing Circle, Paducah, KY 42001
Call Us
~27.91 miles east of Cairo
  • Midscale Rural hotel
  • 85 suites in hotel
More Photos Exterior of Candlewood Suites Paducah by IHG
From£44
Very good 4.0 /5 Guest Reviews Call BookMore Details
Homewood Suites by Hilton Paducah - Paducah 3925 Coleman Crossing Cir, Paducah, KY 42001
Call Us
~27.94 miles east of Cairo
  • 3-star Highway hotel
  • 4 floors in property
More Photos Image of Homewood Suites by Hilton Paducah
From£80
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Comfort Suites - Paducah 3918 Coleman Crossing Cir Paducah Ky 42001, Paducah, KY 42001
Call Us
~27.96 miles east of Cairo
  • Low Cost Rural property
  • 72 suites in hotel
More Photos Image of Comfort Suites
From£44
Average 3.0 /5 Latest Reviews Call BookMore Details
Comfort Inn Paducah 5135 Cairo Rd., Paducah, KY 42001
Call Us
~27.98 miles east of Cairo
  • 3-star property
  • 3 floors in property
More Photos Image of Comfort Inn Paducah
From£43
Very good 4.0 /5 Guest Reviews Call BookMore Details
Fairfield Inn & Suites by Marriott Paducah 3950 Coleman Crossing Circle, Paducah, KY 42001
Call Us
~28.01 miles east of Cairo
  • Affordable Rural property
  • Gym / Fitness Center Available
More Photos Photo of Fairfield Inn & Suites by Marriott Paducah
From£55
Very good 4.0 /5 Recent Reviews Call BookMore Details
Red Roof Inn Paducah 5106 Old Cairo Rd., Paducah, KY 42001
Call Us
~28.01 miles east of Cairo
  • Low Cost hotel
  • Hotel has 3 floors
More Photos Exterior of Red Roof Inn Paducah
From£33
Average 3.5 /5 Reviews Call BookMore Details
American Inn 5125 Cairo Rd., Paducah, KY 42001
Call Us
~28.02 miles east of Cairo
  • Two-star hotel
  • 2 floors in property
More Photos Image of American Inn
From£27
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Hampton Inn & Suites Paducah 3901 Coleman Crossing Circle, Paducah, KY 42001
Call Us
~28.02 miles east of Cairo
  • Midscale Highway property
  • Check-in time: 3:00 pm
More Photos Photo of Hampton Inn & Suites Paducah
From£58
Very good 4.5 /5 Read Reviews Call BookMore Details
Holiday Inn Express Hotel & Suites Paducah West by IHG in Paducah 3996 Hinkleville Rd., Paducah, KY 42001
Call Us
~28.04 miles east of Cairo
  • 3 star Highway property
  • 85 rooms in property
More Photos Exterior of Holiday Inn Express Hotel & Suites Paducah West by IHG
From£58
Average 3.0 /5 Read Reviews Call BookMore Details
Auburn Place Hotel & Suites - Paducah 3994 Hinkleville Rd., Paducah, KY 42001
Call Us
~28.05 miles east of Cairo
  • Midscale Airport hotel
  • Hotel has 3 floors
More Photos Image of Auburn Place Hotel & Suites - Paducah
From£58
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Courtyard by Marriott Paducah 3835 Technology Dr., Paducah, KY 42001
Call Us
~28.29 miles east of Cairo
  • 3-star Suburban hotel
  • Gym is available on property
More Photos Image of Courtyard by Marriott Paducah
From£65
Very good 4.0 /5 Latest Reviews Call BookMore Details
Days Inn by Wyndham Paducah I-24 Exit 4 in Paducah 3901 Hinkleville Rd., Paducah, KY 42001
Call Us
~28.75 miles east of Cairo
  • 2-star Highway hotel
  • 32 suites in hotel
More Photos Exterior of Days Inn by Wyndham Paducah I-24 Exit 4
From£36
Average 3.0 /5 Hotel Reviews Call BookMore Details
Candlewood Suites Cape Girardeau by IHG in Cape Girardeau 485 South Mount Auburn Rd., Cape Girardeau, MO 65703
Call Us
~28.76 miles northwest of Cairo
  • Low Cost Highway hotel
  • 85 rooms in hotel
More Photos Exterior of Candlewood Suites Cape Girardeau by IHG
From£50
Very good 4.0 /5 Reviews Call BookMore Details
Travelers Inn and Suites in Paducah 2550 Lone Oak Rd., Paducah, KY 42003
Call Us
~28.88 miles east of Cairo
  • Low-priced property
  • Check-in: 2:00PM
More Photos Image of Travelers Inn and Suites
From£27
Very good 4.0 /5 Reviews Call BookMore Details
Quality Inn & Suites Metropolis I-24 : 2118 East 5th St. 2118 East 5th St., Metropolis, IL 62960
Call Us
~28.88 miles east of Cairo
  • Mid-scale property
  • 52 rooms in property
More Photos Exterior of Quality Inn & Suites Metropolis I-24
From£58
Very good 4.0 /5 Latest Reviews Call BookMore Details
Super 8 by Wyndham Metropolis 2055 East 5th St., Metropolis, IL 62960
Call Us
~28.89 miles east of Cairo
  • Low-priced Highway hotel
  • Hotel has 6 suites
More Photos Photo of Super 8 by Wyndham Metropolis
From£44
Average 3.0 /5 Read Reviews Call BookMore Details
Motel 6 Metropolis Il in Metropolis 2119 East 5th St., Metropolis, IL 62960
Call Us
~29.04 miles east of Cairo
  • Economy property
More Photos hotel room
From£44
Average 3.0 /5 Recent Reviews Call BookMore Details
Holiday Inn Express Metropolis by IHG 2179 East 5th St., Metropolis, IL 62960
Call Us
~29.10 miles east of Cairo
  • Three Star Rural hotel
  • Check in time: 03:00 PM
More Photos Image of Holiday Inn Express Metropolis by IHG
From£47
Very good 4.0 /5 Reviews Call BookMore Details
Hampton Inn Cape Girardeau I 55 East - Cape Girardeau 207 South Mount Auburn Rd., Cape Girardeau, MO 63703
Call Us
~29.41 miles northwest of Cairo
  • 3 star Highway property
  • Check in time: 3:00 pm
More Photos Photo of Hampton Inn Cape Girardeau I 55 East
From£58
Excellent 5.0 /5 Guest Reviews Call BookMore Details
Victorian Inn & Suites : 3256 William St. 3256 William St., Cape Girardeau, MO 63703
Call Us
~29.41 miles northwest of Cairo
  • 3 star Golf Course property
  • 5 suites in hotel
More Photos hotel room
From£58
Average 3.0 /5 Reviews Call BookMore Details
Auburn Place Hotel & Suites 3265 Williams St., Cape Girardeau, MO 63702
Call Us
~29.42 miles northwest of Cairo
  • Three Star Highway hotel
  • 2 conference rooms in property
More Photos Photo of Auburn Place Hotel & Suites
From£42
Very good 4.5 /5 Read Reviews Call BookMore Details
Holiday Inn Express & Suites Cape Girardeau I 55 by Ihg : 3253 William St. 3253 William St., Cape Girardeau, MO 63701
Call Us
~29.49 miles northwest of Cairo
  • Mid-scale property
  • Gym is available on property
More Photos Image of Holiday Inn Express & Suites Cape Girardeau I 55 by Ihg
From£58
Very good 4.5 /5 Recent Reviews Call BookMore Details
Fairfield Inn & Suites Cape Girardeau : 433 Cape West Crossing 433 Cape West Crossing, Cape Girardeay, MO 63703
Call Us
~29.58 miles northwest of Cairo
  • Midscale property
  • 103 rooms in property
More Photos hotel room
From£58
Average 3.0 /5 Guest Reviews Call BookMore Details
Drury Suites Cape Girardeau 3303 Campster Dr., Cape Girardeau, MO 63701
Call Us
~29.72 miles northwest of Cairo
  • Midscale Highway property
  • Hotel has 79 suites
More Photos Exterior of Drury Suites Cape Girardeau
From£62
Very good 4.5 /5 Review Score Call BookMore Details
Drury Lodge 104 South Vantage Dr., Cape Girardeau, MO 63701
Call Us
~29.82 miles northwest of Cairo
  • Midscale Highway hotel
  • Access to gym on-site
More Photos Image of Drury Lodge
From£58
Average 3.0 /5 Guest Reviews Call BookMore Details

Next: See My Cairo Hotels with Pricing

Graph: Upcoming 20 Days of Cairo Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Cairo, IL discounts available. The chart reflects the cheapest Cairo hotel for each day and each star rating category.

FAQs about hotels in Cairo

What are the most favored hotels in Cairo?

Hampton Inn Cape Girardeau I 55 East, Hampton Inn & Suites Paducah and Auburn Place Hotel & Suites are the best rated hotels based on customer reviews in the last 365 days.

What are the most luxurious hotels in Cairo?

Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destinatio, Quality Inn Cairo I-57 and Travel Inn & Suites - Sikeston are the top 3 luxury hotels near Cairo city center.

What hotels are closest to the city center of Cairo?

Quality Inn Cairo I-57, Super 8 by Wyndham Charleston, and Quality Inn Charleston - Sikeston are the properties closest to Cairo city center.

What are the best independent hotels in Cairo?

Auburn Place Hotel & Suites, Drury Suites Cape Girardeau and Travel Inn & Suites - Sikeston are the best rated independent hotels (not part of a big brand).

What are the most popular Marriott hotels in Cairo?

Residence Inn by Marriott Paducah, Courtyard by Marriott Cape Girardeau Downtown and Fairfield Inn & Suites by Marriott Paducah are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the best Choice Hotels branded hotels in Cairo?

Comfort Inn & Suites near Six Flags, Comfort Inn Paducah and Quality Inn & Suites Metropolis I-24 are the best rated Choice Hotels branded hotels (based on HotelPlanner reviews score).

What are the best IHG hotels in Cairo?

Holiday Inn Express & Suites Cape Girardeau I 55 by Ihg, Candlewood Suites Paducah by IHG and Candlewood Suites Cape Girardeau by IHG are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

Verified reviews of the city: Cairo, IL

Below are reviews of the city of Cairo, IL from an actual visitor's perspective.

"Spending time with my family"
Score 5.0 / 5

Vincent R., from 26-Jan-2026
The average traveler rating of the city of Cairo, IL shown above is 5.0 out of 5 based on 1 reviews
Back to Top