Charleston Missouri Hotels & Motels

Find the perfect hotel in Charleston using our hotel guide provided below. Find discounted hotel accommodations in or close to Charleston, MO for your upcoming individual or group travel. Discover the most popular Charleston, Missouri hotel and motel rooms. Browse the Charleston area hotels to find the perfect lodging! Please use the provided map of the Charleston hotels. Coordinating a group? Get Charleston Group Hotel Rates

Charleston Hotels & Accommodations

Super 8 by Wyndham Charleston/Sikeston East MO : 310 South Story
+1-888-389-4121

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New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
310 South Story, Charleston, MO 63834 +1-888-389-4121
  • Economy Highway hotel
  • Free complimentary breakfast
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From£31
Average 3.5 /5 Hotel Reviews Call BookMore Details
Quality Inn Charleston - Sikeston : 102 Drake St.
+1-888-675-2083

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New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
102 Drake St., Charleston, MO 63834 +1-888-675-2083
  • Economy Highway property
  • Free breakfast
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From£44
Average 3.0 /5 Latest Reviews Call BookMore Details
Motel 6 Sikeston Mo in SIKESTON
+1-800-716-8490

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New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
110 South Interstate Dr., SIKESTON, MO 63801 +1-800-716-8490 ~11.02 miles west of Charleston
  • 2-star hotel
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From£45
Average 3.0 /5 Recent Reviews Call BookMore Details
Best Western Plus Sikeston in Sikeston
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
120 South Interstate Dr., Sikeston, MO 63801 +1-800-805-5223 ~11.05 miles west of Charleston
  • Cheap Highway property
  • Hotel has a green policy See more
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From£32
Very good 4.0 /5 Guest Reviews Call BookMore Details
Days Inn and Suites by Wyndham Sikeston - Sikeston
+1-888-965-1860

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New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
220 South Interstate Dr., Sikeston, MO 63801 +1-888-965-1860 ~11.09 miles west of Charleston
  • Two star property
  • Check-in: 03:00 PM
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From£45
Average 3.0 /5 Latest Reviews Call BookMore Details
Quality Inn Cairo I-57
+1-888-788-5576

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New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
13201 Kessler Rd., Cairo, IL 62914 +1-888-788-5576 ~11.20 miles northeast of Charleston
  • Affordable Highway property
  • 38 rooms in hotel
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From£45
Poor 2.0 /5 Recent Reviews Call BookMore Details
Super 8 by Wyndham Sikeston/Miner Area
+1-888-897-9207

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New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
2609 East Malone, Sikeston, MO 63801 +1-888-897-9207 ~11.36 miles west of Charleston
  • Inexpensive Convention Center property
  • Check in: 01:00
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From£45
Average 3.0 /5 Guest Reviews Call BookMore Details
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) - Sikeston
+1-888-311-4278

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New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
100 Matthews Lane, Sikeston, MO 63801 +1-888-311-4278 ~11.37 miles west of Charleston
  • Affordable Highway property
  • Comp. Breakfast
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From£60
Very good 4.0 /5 Review Score Call BookMore Details
Comfort Inn : 109 Matthews Lane
+1-888-469-4795

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New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
109 Matthews Lane, Sikeston, MO 63801 +1-888-469-4795 ~11.40 miles west of Charleston
  • Mid-scale Highway hotel
  • Check-in: 11:00
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From£63
Average 3.0 /5 Read Reviews Call BookMore Details
Drury Inn & Suites Sikeston : 2608 East Malone Ave.
+1-888-734-9421

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New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
2608 East Malone Ave., Sikeston, MO 63801 +1-888-734-9421 ~11.45 miles west of Charleston
  • Midscale Highway property
  • Hotel has 14 suites
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From£78
Very good 4.5 /5 Hotel Reviews Call BookMore Details
Pear Tree Inn Sikeston
+1-888-841-5292

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New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
2602 East Malone, Sikeston, MO 63801 +1-888-841-5292 ~11.45 miles west of Charleston
  • Affordable Suburban property
  • Hotel has 2 suites
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From£60
Average 3.0 /5 Recent Reviews Call BookMore Details
Hampton Inn Sikeston in Sikeston
+1-888-455-5160

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New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
1240 Commerce Dr., Sikeston, MO 63801 +1-888-455-5160 ~14.31 miles west of Charleston
  • Three Star Rural hotel
  • Free comp. breakfast
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From£60
Average 3.0 /5 Review Score Call BookMore Details
Holiday Inn Express & Suites Sikeston An Ihg Hotel - Sikeston
+1-888-965-8297

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New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
115 Hospitality Dr., Sikeston, MO 63801 +1-888-965-8297 ~14.33 miles west of Charleston
  • 3-star Rural property
  • Fitness + Health Center
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From£60
Average 3.0 /5 Guest Reviews Call BookMore Details
Americas Best Value Inn Ullin Mounds - Ullin
+1-888-906-6358

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New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
128 Cheekwood Lane, Ullin, IL 62992 +1-888-906-6358 ~25.98 miles north of Charleston
  • 2 star property
  • 40 rooms in property
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From£45
Average 3.0 /5 Latest Reviews Call BookMore Details
Courtyard by Marriott Cape Girardeau Downtown
+1-888-749-6785

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New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
400 Broadway St., Cape Girardeau, MO 63701 +1-888-749-6785 ~28.56 miles north of Charleston
  • 3 star Downtown hotel
  • Fitness / Gym is on-site
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From£60
Very good 4.0 /5 Recent Reviews Call BookMore Details
Candlewood Suites Cape Girardeau by IHG in Cape Girardeau
+1-888-878-9982

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New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
485 South Mount Auburn Rd., Cape Girardeau, MO 65703 +1-888-878-9982 ~28.61 miles northwest of Charleston
  • Two star Highway property
  • Has environment-friendly policy See more
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From£51
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Hampton Inn Cape Girardeau I 55 East in Cape Girardeau
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
207 South Mount Auburn Rd., Cape Girardeau, MO 63703 +1-888-389-4485 ~29.33 miles northwest of Charleston
  • 3-star Highway hotel
  • Free breakfast available
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From£60
Excellent 5.0 /5 Guest Reviews Call BookMore Details
Victorian Inn & Suites in Cape Girardeau
+1-888-389-4121

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New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
3256 William St., Cape Girardeau, MO 63703 +1-888-389-4121 ~29.40 miles northwest of Charleston
  • Mid-scale Golf Course hotel
  • Check-in: 3:00 pm
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From£59
Average 3.0 /5 Recent Reviews Call BookMore Details
Auburn Place Hotel & Suites
+1-888-675-2083

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New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
3265 Williams St., Cape Girardeau, MO 63702 +1-888-675-2083 ~29.41 miles northwest of Charleston
  • Affordable Highway hotel
  • 2 conference rooms in property
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From£43
Very good 4.5 /5 Read Reviews Call BookMore Details
Holiday Inn Express & Suites Cape Girardeau I 55
+1-800-716-8490

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New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
3253 William St., Cape Girardeau, MO 63701 +1-800-716-8490 ~29.43 miles northwest of Charleston
  • 3 star property
  • Hotel has 102 rooms
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From£60
Very good 4.5 /5 Hotel Reviews Call BookMore Details
Fairfield Inn & Suites Cape Girardeau in Cape Girardeay
+1-800-805-5223

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New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
433 Cape West Crossing, Cape Girardeay, MO 63703 +1-800-805-5223 ~29.46 miles northwest of Charleston
  • 3 star hotel
  • 103 sleeping rooms in hotel
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From£60
Average 3.0 /5 Latest Reviews Call BookMore Details
Pear Tree Inn Cape Girardeau West : 103 Cape West Pkwy.
+1-888-965-1860

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New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
103 Cape West Pkwy., Cape Girardeau, MO 63701 +1-888-965-1860 ~29.49 miles northwest of Charleston
  • 2-star hotel
  • Access to gym on-site
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From£44
Average 3.0 /5 Recent Reviews Call BookMore Details
Pear Tree Inn Cape Girardeau Medical Center - Cape Girardeau
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
3248 William St., Cape Girardeau, MO 63701 +1-888-788-5576 ~29.50 miles northwest of Charleston
  • Economy Highway hotel
  • Free complimentary breakfast
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From£49
Very good 4.0 /5 Guest Reviews Call BookMore Details
Drury Suites Cape Girardeau
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
3303 Campster Dr., Cape Girardeau, MO 63701 +1-888-897-9207 ~29.60 miles northwest of Charleston
  • 3-star Highway hotel
  • Access to gym on-site
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From£63
Very good 4.5 /5 Recent Reviews Call BookMore Details
Drury Plaza Hotel & Conference Center Cape Girardeau : 3351 Percy Dr.
+1-888-311-4278

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New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
3351 Percy Dr., Cape Girardeau, MO 63701 +1-888-311-4278 ~29.76 miles northwest of Charleston
  • Affordable property
  • Gym is available on property
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From£44
Average 3.0 /5 Review Score Call BookMore Details
Drury Lodge
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
104 South Vantage Dr., Cape Girardeau, MO 63701 +1-888-469-4795 ~29.77 miles northwest of Charleston
  • Midscale Highway property
  • Free breakfast available
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From£60
Average 3.0 /5 Read Reviews Call BookMore Details
Travel Inn in Marston
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
301 Route Ad, Marston, MO 63866 +1-888-734-9421 ~31.28 miles southwest of Charleston
  • Cheap Highway hotel
  • 60 rooms in property
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From£30
Poor 2.5 /5 Guest Reviews Call BookMore Details
Travel Inn : 301 State Highway Ad
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
301 State Highway Ad, Martson, MO 63866 +1-888-841-5292 ~31.46 miles southwest of Charleston
  • Cheap hotel
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From£45
Poor 2.5 /5 Read Reviews Call BookMore Details
Red Roof Inn Marston
+1-888-455-5160

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New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
501 South Outer Rd., Marston, MO 63866 +1-888-455-5160 ~31.61 miles southwest of Charleston
  • Low Cost hotel
  • Hotel has 2 floors
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From£45
Average 3.0 /5 Reviews Call BookMore Details
Quality Inn
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
2011 North Kingshighway St., Cape Girardeau, MO 63701 Website +1-888-965-8297 ~31.73 miles northwest of Charleston
  • Two-star property
  • Has environment-friendly policy Read more
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From£45
Very good 4.0 /5 Reviews Call BookMore Details
TRU by Hilton Cape Girardeau
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
2520 Veterans Memorial Dr., Cape Girardeau, MO 63701 +1-888-906-6358 ~32.92 miles northwest of Charleston
  • Midscale Highway property
  • Gym is available on property
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From£60
Average 3.0 /5 Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham Jackson / Cape Girardeau - Jackson
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
3003 South Old Orchard Rd., Jackson, MO 63755 +1-888-749-6785 ~33.46 miles northwest of Charleston
  • 3 star Highway hotel
  • 4 floors in property
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From£63
Very good 4.0 /5 Reviews Call BookMore Details
Comfort Suites Jackson-Cape Girardeau
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
2904 Old Orchard Rd., Jackson, MO 63755 Website +1-888-878-9982 ~33.57 miles northwest of Charleston
  • Mid-scale Highway property
  • Free complimentary breakfast
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From£48
Average 3.0 /5 Reviews Call BookMore Details
Comfort Suites - Jackson
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
2904 Old Orchard Rd., Jackson, 63755 United States +1-888-389-4485 ~33.57 miles northwest of Charleston
  • 4 star Highway hotel
  • Gym is available on property
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From£93
Average 3.0 /5 Latest Reviews Call BookMore Details
Residence Inn by Marriott Paducah
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
3900 Coleman Crossing Circle, Paducah, KY 42001 +1-888-389-4121 ~34.97 miles east of Charleston
  • 3 star Suburban hotel
  • 74 suites in property
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From£66
Very good 4.0 /5 Recent Reviews Call BookMore Details
Pear Tree Inn Paducah
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
5006 Hinkleville Rd., Paducah, KY 42001 +1-888-675-2083 ~35.47 miles east of Charleston
  • Cheap Suburban property
  • 59 rooms in property
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From£41
Very good 4.0 /5 Guest Reviews Call BookMore Details
Econo Lodge Dexter
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
913 Outer Rd., Dexter, MO 63841 +1-800-716-8490 ~36.12 miles west of Charleston
  • Cheap hotel
  • Check-in time: 11:00
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From£45
Average 3.0 /5 Reviews Call BookMore Details
Harrah's Metropolis Hotel & Casino - Metropolis
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
100 East Front St., Metropolis, IL 62960 +1-800-805-5223 ~36.52 miles east of Charleston
  • Four-star hotel
  • Hotel has 12 suites
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From£120
Very good 4.0 /5 Read Reviews Call BookMore Details
Baymont by Wyndham Metropolis : 203 East Front St.
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
203 East Front St., Metropolis, IL 62960 +1-888-965-1860 ~36.55 miles east of Charleston
  • Inexpensive Riverfront hotel
  • Hotel has 8 suites
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From£33
Average 3.0 /5 Recent Reviews Call BookMore Details
Sleep Inn & Mainstay Suites - Union City
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
1111 Blue Heron Lane, Union City, TN 38261 +1-888-788-5576 ~36.64 miles southeast of Charleston
  • Cheap Rural hotel
  • Check-in time: 15:00
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From£45
Average 3.0 /5 Review Score Call BookMore Details
Travelodge by Wyndham Dexter
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
1608 West Business U.s. 60, Dexter, MO 63841 +1-888-897-9207 ~36.87 miles west of Charleston
  • Three Star property
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From£50
Very good 4.0 /5 Read Reviews Call BookMore Details
 Econo Lodge Paducah West I-24
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
5120 Hinkleville Rd., Paducah, KY 42001 +1-888-311-4278 ~37.23 miles east of Charleston
  • Economical Airport property
  • 2 floors in hotel
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From£45
Average 3.0 /5 Recent Reviews Call BookMore Details
Drury Suites Paducah
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
2930 James Sanders Blvd., Paducah, KY 42001 +1-888-469-4795 ~37.34 miles east of Charleston
  • 3 star Suburban property
  • 120 suites in hotel
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From£74
Very good 4.0 /5 Read Reviews Call BookMore Details
Quality Suites Paducah I-24 : 2880 James Sanders Blvd.
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
2880 James Sanders Blvd., Paducah, KY 42001 Website +1-888-734-9421 ~37.41 miles east of Charleston
  • Low-priced Highway hotel
  • Has environment-friendly policy Read more
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From£45
Average 3.0 /5 Latest Reviews Call BookMore Details
Sleep Inn Union City in Union City
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
1111b Blue Heron Lane, Union City, TN 38261 +1-888-841-5292 ~37.44 miles southeast of Charleston
  • Two star Rural hotel
  • Check in time: 3:00 PM
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From£58
Very good 4.0 /5 Guest Reviews Call BookMore Details
Comfort Inn & Suites near Six Flags - Lithia Springs
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
960 West Pointe Court, Lithia Springs, GA 30122 Website +1-888-455-5160 ~37.46 miles east of Charleston
  • Affordable Downtown hotel
  • Check in: 3:00pm
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From£52
Very good 4.0 /5 Guest Reviews Call BookMore Details
Country Inn & Suites by Radisson, Paducah, KY in Paducah
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
145 Mcbride Lane, Paducah, KY 42001 +1-888-965-8297 ~37.46 miles east of Charleston
  • Affordable Highway property
  • Access to gym on-site
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From£36
Very good 4.0 /5 Review Score Call BookMore Details
Baymont by Wyndham Paducah
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
5300 Old Cairo Rd., Paducah, KY 42001 +1-888-906-6358 ~37.50 miles east of Charleston
  • Three Star hotel
  • Hotel has 74 rooms
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From£30
Poor 2.0 /5 Latest Reviews Call BookMore Details
Hotel 7 Inn
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
5001 Hinkleville Rd., Paducah, KY 42001 +1-888-749-6785 ~37.51 miles east of Charleston
  • Two star hotel
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From£45
Average 3.0 /5 Read Reviews Call BookMore Details
Econo Lodge
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
1415 East 5th St., Metropolis, IL 62960 +1-888-878-9982 ~37.60 miles east of Charleston
  • Low priced property
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From£45
Terrible 1.0 /5 Reviews Call BookMore Details

Next: See My Charleston Hotels with Pricing

Recent traveler reviews of Charleston, MO

Below are reviews of the city of Charleston, MO from an actual visitor's perspective.

"Easily Accessible"
Score 5.0 / 5

Easily accessible.

Mamon T., from 07-Dec-2023
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