Cairo Illinois Accommodations

Find hotels & motels in Cairo using the list below. Search for cheap and discounted hotel and motel rates in or close to Cairo, IL for your upcoming individual or group travel. Discover the best Cairo Illinois hotel/motel rooms. Review the Cairo hotel list below to find the perfect lodging. We also have a map of the Cairo hotels.

Cairo Hotels/Motels & Accommodations

Quality Inn Cairo I-57 : 13201 Kessler Rd. 13201 Kessler Rd., Cairo, IL 62914 Call
  • 3 star Highway property
  • Check-in time: 3 pm
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From$60
Poor 2.0 /5 Latest Reviews Call BookMore Details
Super 8 by Wyndham Charleston/Sikeston East MO 310 South Story, Charleston, MO 63834 Call ~10.13 miles southwest of Cairo
  • Low priced Highway property
  • Check-in time: 3:00pm
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From$42
Average 3.5 /5 Guest Reviews Call BookMore Details
Quality Inn Charleston - Sikeston 102 Drake St., Charleston, MO 63834 Call ~11.88 miles southwest of Cairo
  • Inexpensive Highway property
  • 9 suites in property
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From$59
Average 3.0 /5 Recent Reviews Call BookMore Details
Americas Best Value Inn Ullin Mounds 128 Cheekwood Lane, Ullin, IL 62992 Call ~17.88 miles north of Cairo
  • Two-star property
  • Comp. Breakfast
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From$60
Average 3.0 /5 Recent Reviews Call BookMore Details
Motel 6 Sikeston Mo 110 South Interstate Dr., SIKESTON, MO 63801 Call ~20.96 miles west of Cairo
  • Cheap hotel
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From$60
Average 3.0 /5 Recent Reviews Call BookMore Details
Best Western Plus Sikeston : 120 South Interstate Dr. 120 South Interstate Dr., Sikeston, MO 63801 Call ~21.00 miles west of Cairo
  • Low priced Highway property
  • Free comp. breakfast
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From$43
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Days Inn and Suites by Wyndham Sikeston 220 South Interstate Dr., Sikeston, MO 63801 Call ~21.07 miles west of Cairo
  • Cheap hotel
  • Fitness center on property
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From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) : 100 Matthews Lane 100 Matthews Lane, Sikeston, MO 63801 Call ~21.31 miles west of Cairo
  • Three Star Highway hotel
  • Free breakfast available
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From$80
Very Good 4.0 /5 Review Score Call BookMore Details
Super 8 by Wyndham Sikeston/Miner Area 2609 East Malone, Sikeston, MO 63801 Call ~21.32 miles west of Cairo
  • Low priced Convention Center property
  • Free complimentary breakfast
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From$60
Average 3.0 /5 Recent Reviews Call BookMore Details
Comfort Inn : 109 Matthews Lane 109 Matthews Lane, Sikeston, MO 63801 Call ~21.34 miles west of Cairo
  • Mid-scale Highway hotel
  • Check in time: 11:00
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From$85
Average 3.0 /5 Reviews Call BookMore Details
Hampton Inn Sikeston in Sikeston 1240 Commerce Dr., Sikeston, MO 63801 Call ~24.48 miles west of Cairo
  • 3-star Rural property
  • Gym is available on property
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From$80
Average 3.0 /5 Recent Reviews Call BookMore Details
Holiday Inn Express & Suites Sikeston An Ihg Hotel in Sikeston 115 Hospitality Dr., Sikeston, MO 63801 Call ~24.49 miles west of Cairo
  • Affordable Rural hotel
  • Access to gym on-site
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From$80
Average 3.0 /5 Latest Reviews Call BookMore Details
Residence Inn by Marriott Paducah 3900 Coleman Crossing Circle, Paducah, KY 42001 Call ~25.66 miles east of Cairo
  • Midscale Suburban property
  • 2 meeting rooms in property
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From$89
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destinatio 100 East Front St., Metropolis, IL 62960 Call ~26.28 miles east of Cairo
  • Four star hotel
  • 7 floors in property
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From$160
Very Good 4.0 /5 Review Score Call BookMore Details
Baymont by Wyndham Metropolis 203 East Front St., Metropolis, IL 62960 Call ~26.32 miles east of Cairo
  • Low priced Riverfront property
  • Free complimentary breakfast
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From$45
Average 3.0 /5 Reviews Call BookMore Details
Econo Lodge - Metropolis 1415 East 5th St., Metropolis, IL 62960 Call ~27.38 miles east of Cairo
  • Low-priced property
  • 45 sleeping rooms in hotel
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From$60
Not Good 1.0 /5 Reviews Call BookMore Details
 Econo Lodge Paducah West I-24 5120 Hinkleville Rd., Paducah, KY 42001 Call ~27.55 miles east of Cairo
  • Economy Airport property
  • 75 sleeping rooms in hotel
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From$60
Average 3.0 /5 Recent Reviews Call BookMore Details
Baymont by Wyndham Paducah 5300 Old Cairo Rd., Paducah, KY 42001 Call ~27.64 miles east of Cairo
  • Three Star hotel
  • 74 rooms in hotel
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From$40
Poor 2.0 /5 Reviews Call BookMore Details
Courtyard by Marriott Cape Girardeau Downtown - Cape Girardeau 400 Broadway St., Cape Girardeau, MO 63701 Call ~27.65 miles northwest of Cairo
  • Midscale Downtown property
  • 5 floors in hotel
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From$80
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Drury Suites Paducah 2930 James Sanders Blvd., Paducah, KY 42001 Call ~27.70 miles east of Cairo
  • Three Star Suburban hotel
  • Free comp. breakfast
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From$99
Very Good 4.0 /5 Review Score Call BookMore Details
Quality Suites Paducah I-24 - Paducah 2880 James Sanders Blvd., Paducah, KY 42001 Website Call ~27.73 miles east of Cairo
  • 2 star Highway property
  • 59 rooms in property
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From$60
Average 3.0 /5 Latest Reviews Call BookMore Details
Comfort Inn & Suites near Six Flags - Lithia Springs 960 West Pointe Court, Lithia Springs, GA 30122 Website Call ~27.80 miles east of Cairo
  • Midscale Downtown property
  • Check in time: 3:00pm
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From$70
Very Good 4.0 /5 Read Reviews Call BookMore Details
Garner Hotel Paducah West by IHG : 145 Mcbride Lane 145 Mcbride Lane, Paducah, KY 42001 Call ~27.80 miles east of Cairo
  • Midscale Highway hotel
  • 17 suites in hotel
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From$49
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Hotel 7 Inn Paducah 5001 Hinkleville Rd., Paducah, KY 42001 Call ~27.81 miles east of Cairo
  • Low Cost hotel
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From$60
Average 3.0 /5 Latest Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham Paducah in Paducah 3960 Coleman Crossing Cir, Paducah, KY 42001 Call ~27.90 miles east of Cairo
  • 3-star Highway hotel
  • 77 sleeping rooms in hotel
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From$80
Average 3.0 /5 Recent Reviews Call BookMore Details
Candlewood Suites Paducah by IHG 3940 Coleman Crossing Circle, Paducah, KY 42001 Call ~27.91 miles east of Cairo
  • Three Star Rural property
  • 85 suites in hotel
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From$60
Very Good 4.0 /5 Reviews Call BookMore Details
Homewood Suites by Hilton Paducah in Paducah 3925 Coleman Crossing Cir, Paducah, KY 42001 Call ~27.94 miles east of Cairo
  • Three Star Highway hotel
  • Fitness / Gym is on-site
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From$109
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Comfort Suites - Paducah 3918 Coleman Crossing Cir Paducah Ky 42001, Paducah, KY 42001 Call ~27.96 miles east of Cairo
  • Economical Rural property
  • Hotel has 4 floors
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From$60
Average 3.0 /5 Read Reviews Call BookMore Details
Comfort Inn Paducah in Paducah 5135 Cairo Rd., Paducah, KY 42001 Call ~27.98 miles east of Cairo
  • 3-star property
  • 3 floors in hotel
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From$59
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Fairfield Inn & Suites by Marriott Paducah 3950 Coleman Crossing Circle, Paducah, KY 42001 Call ~28.01 miles east of Cairo
  • 3 star Rural property
  • 2 meeting rooms in property
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From$75
Very Good 4.0 /5 Reviews Call BookMore Details
Red Roof Inn Paducah - Paducah 5106 Old Cairo Rd., Paducah, KY 42001 Call ~28.01 miles east of Cairo
  • 2 star property
  • Hotel has 3 floors
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From$45
Average 3.5 /5 Read Reviews Call BookMore Details
American Inn in Paducah 5125 Cairo Rd., Paducah, KY 42001 Call ~28.02 miles east of Cairo
  • Two star hotel
  • Check in time: 14:00
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From$37
Very Good 4.0 /5 Read Reviews Call BookMore Details
Hampton Inn & Suites Paducah 3901 Coleman Crossing Circle, Paducah, KY 42001 Call ~28.02 miles east of Cairo
  • Midscale Highway property
  • Hotel has 4 floors
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From$79
Very Good 4.5 /5 Read Reviews Call BookMore Details
Holiday Inn Express Hotel & Suites Paducah West by IHG in Paducah 3996 Hinkleville Rd., Paducah, KY 42001 Call ~28.04 miles east of Cairo
  • Three Star Highway property
  • 85 rooms in hotel
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From$80
Average 3.0 /5 Read Reviews Call BookMore Details
Auburn Place Hotel & Suites - Paducah : 3994 Hinkleville Rd. 3994 Hinkleville Rd., Paducah, KY 42001 Call ~28.05 miles east of Cairo
  • Midscale Airport property
  • 76 suites in property
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From$80
Very Good 4.0 /5 Reviews Call BookMore Details
Courtyard by Marriott Paducah 3835 Technology Dr., Paducah, KY 42001 Call ~28.29 miles east of Cairo
  • Mid-scale Suburban hotel
  • Fitness + Health Center
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From$89
Very Good 4.0 /5 Review Score Call BookMore Details
Days Inn by Wyndham Paducah I-24 Exit 4 3901 Hinkleville Rd., Paducah, KY 42001 Call ~28.75 miles east of Cairo
  • Low priced Highway property
  • 32 suites in hotel
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From$50
Average 3.0 /5 Latest Reviews Call BookMore Details
Candlewood Suites Cape Girardeau by IHG - Cape Girardeau 485 South Mount Auburn Rd., Cape Girardeau, MO 65703 Call ~28.76 miles northwest of Cairo
  • Low-priced Highway property
  • 4 floors in hotel
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From$69
Very Good 4.0 /5 Read Reviews Call BookMore Details
Travelers Inn and Suites in Paducah 2550 Lone Oak Rd., Paducah, KY 42003 Call ~28.88 miles east of Cairo
  • Economy property
  • Hotel has 2 floors
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From$38
Very Good 4.0 /5 Read Reviews Call BookMore Details
Quality Inn & Suites Metropolis I-24 - Metropolis 2118 East 5th St., Metropolis, IL 62960 Call ~28.88 miles east of Cairo
  • Three Star property
  • 52 sleeping rooms in hotel
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From$80
Very Good 4.0 /5 Reviews Call BookMore Details
Super 8 by Wyndham Metropolis - Metropolis 2055 East 5th St., Metropolis, IL 62960 Call ~28.89 miles east of Cairo
  • Cheap Highway hotel
  • 6 suites in hotel
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From$60
Average 3.0 /5 Reviews Call BookMore Details
Motel 6 Metropolis Il 2119 East 5th St., Metropolis, IL 62960 Call ~29.04 miles east of Cairo
  • Economy hotel
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From$60
Average 3.0 /5 Read Reviews Call BookMore Details
Holiday Inn Express Metropolis by IHG : 2179 East 5th St. 2179 East 5th St., Metropolis, IL 62960 Call ~29.10 miles east of Cairo
  • 3 star Rural hotel
  • Complimentary breakfast is offered
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From$65
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Hampton Inn Cape Girardeau I 55 East 207 South Mount Auburn Rd., Cape Girardeau, MO 63703 Call ~29.41 miles northwest of Cairo
  • 3 star Highway property
  • Check-in: 3:00 pm
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From$80
Excellent 5.0 /5 Hotel Reviews Call BookMore Details
Victorian Inn & Suites - Cape Girardeau 3256 William St., Cape Girardeau, MO 63703 Call ~29.41 miles northwest of Cairo
  • Three Star Golf Course property
  • 5 suites in hotel
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From$79
Average 3.0 /5 Review Score Call BookMore Details
Auburn Place Hotel & Suites 3265 Williams St., Cape Girardeau, MO 63702 Call ~29.42 miles northwest of Cairo
  • 3 star Highway hotel
  • 2 meeting rooms in property
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From$58
Very Good 4.5 /5 Guest Reviews Call BookMore Details
Holiday Inn Express & Suites Cape Girardeau I 55 by Ihg 3253 William St., Cape Girardeau, MO 63701 Call ~29.49 miles northwest of Cairo
  • 3-star hotel
  • Hotel has 4 floors
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From$80
Very Good 4.5 /5 Recent Reviews Call BookMore Details
Fairfield Inn & Suites Cape Girardeau : 433 Cape West Crossing 433 Cape West Crossing, Cape Girardeay, MO 63703 Call ~29.58 miles northwest of Cairo
  • Affordable hotel
  • Check in time: 3:00PM
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From$80
Average 3.0 /5 Reviews Call BookMore Details
Drury Suites Cape Girardeau - Cape Girardeau 3303 Campster Dr., Cape Girardeau, MO 63701 Call ~29.72 miles northwest of Cairo
  • Affordable Highway hotel
  • 86 rooms in property
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From$85
Very Good 4.5 /5 Read Reviews Call BookMore Details
Drury Lodge 104 South Vantage Dr., Cape Girardeau, MO 63701 Call ~29.82 miles northwest of Cairo
  • 3-star Highway property
  • Check-in time: 3:00pm
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From$80
Average 3.0 /5 Guest Reviews Call BookMore Details

Next: See My Cairo Hotels with Pricing

Verified reviews of the city: Cairo, IL

Below are reviews of the city of Cairo, IL from an actual visitor's perspective.

"Spending time with my family"
Score 5.0 / 5

Vincent R., from 26-Jan-2026
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