Cairo Illinois Accommodations

Find hotels & motels in Cairo using the list below. Search for cheap and discounted hotel and motel rates in or close to Cairo, IL for your upcoming individual or group travel. Discover the best Cairo Illinois hotel/motel rooms. Review the Cairo hotel list below to find the perfect lodging. We also have a map of the Cairo hotels.

Cairo Hotels/Accommodations

Quality Inn Cairo I-57 : 13201 Kessler Rd. 13201 Kessler Rd., Cairo, IL 62914 Call
  • 3-star Highway hotel
  • 38 rooms in hotel
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From$60
Poor 2.0 /5 Review Score Call BookMore Details
Super 8 by Wyndham Charleston/Sikeston East MO : 310 South Story 310 South Story, Charleston, MO 63834 Call ~10.13 miles southwest of Cairo
  • Two-star Highway property
  • 60 sleeping rooms in hotel
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From$42
Average 3.5 /5 Reviews Call BookMore Details
The Riverstone Hotel Charleston-Sikeston in Charleston 102 Drake St., Charleston, MO 63834 Call ~11.88 miles southwest of Cairo
  • Inexpensive Highway hotel
  • Fitness center on property
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From$59
Average 3.0 /5 Read Reviews Call BookMore Details
Americas Best Value Inn Ullin Mounds 128 Cheekwood Lane, Ullin, IL 62992 Call ~17.88 miles north of Cairo
  • Low Cost property
  • Free breakfast
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From$60
Average 3.0 /5 Reviews Call BookMore Details
Motel 6 Sikeston Mo : 110 South Interstate Dr. 110 South Interstate Dr., SIKESTON, MO 63801 Call ~20.96 miles west of Cairo
  • 2-star hotel
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From$60
Average 3.0 /5 Reviews Call BookMore Details
Best Western Plus Sikeston I-55 in Sikeston 120 South Interstate Dr., Sikeston, MO 63801 Call ~21.00 miles west of Cairo
  • 2 star Highway hotel
  • Check-in time: 03:00
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From$42
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Days Inn and Suites by Wyndham Sikeston : 220 South Interstate Dr. 220 South Interstate Dr., Sikeston, MO 63801 Call ~21.07 miles west of Cairo
  • Low-priced property
  • Gym is available on property
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From$60
Average 3.0 /5 Reviews Call BookMore Details
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) : 100 Matthews Lane 100 Matthews Lane, Sikeston, MO 63801 Call ~21.31 miles west of Cairo
  • Three Star Highway property
  • Check in: 3:00 PM
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From$80
Very Good 4.0 /5 Review Score Call BookMore Details
Super 8 by Wyndham Sikeston/Miner Area in Sikeston 2609 East Malone, Sikeston, MO 63801 Call ~21.32 miles west of Cairo
  • Cheap Convention Center hotel
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From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
Comfort Inn - Sikeston 109 Matthews Lane, Sikeston, MO 63801 Call ~21.34 miles west of Cairo
  • Mid-scale Highway hotel
  • Access to gym on-site
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From$85
Average 3.0 /5 Reviews Call BookMore Details
Hampton Inn Sikeston in Sikeston 1240 Commerce Dr., Sikeston, MO 63801 Call ~24.48 miles west of Cairo
  • Midscale Rural property
  • Fitness center on property
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From$80
Average 3.0 /5 Reviews Call BookMore Details
Holiday Inn Express & Suites Sikeston An Ihg Hotel 115 Hospitality Dr., Sikeston, MO 63801 Call ~24.49 miles west of Cairo
  • Affordable Rural hotel
  • Check-in: 3:00pm
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From$80
Average 3.0 /5 Read Reviews Call BookMore Details
Residence Inn by Marriott Paducah in Paducah 3900 Coleman Crossing Circle, Paducah, KY 42001 Call ~25.66 miles east of Cairo
  • Mid-scale Suburban hotel
  • 3 floors in hotel
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From$89
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destinatio - Metropolis 100 East Front St., Metropolis, IL 62960 Call ~26.28 miles east of Cairo
  • Expensive hotel
  • 252 rooms in property
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From$160
Very Good 4.0 /5 Review Score Call BookMore Details
Baymont by Wyndham Metropolis in Metropolis 203 East Front St., Metropolis, IL 62960 Call ~26.32 miles east of Cairo
  • Economy Riverfront property
  • 2 floors in property
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From$45
Average 3.0 /5 Reviews Call BookMore Details
Econo Lodge in Metropolis 1415 East 5th St., Metropolis, IL 62960 Call ~27.38 miles east of Cairo
  • Low Cost property
  • 45 rooms in property
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From$60
Not Good 1.0 /5 Review Score Call BookMore Details
 Econo Lodge Paducah West I-24 - Paducah 5120 Hinkleville Rd., Paducah, KY 42001 Call ~27.55 miles east of Cairo
  • Economical Airport hotel
  • Check in: 15:00pm
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From$60
Average 3.0 /5 Read Reviews Call BookMore Details
Baymont by Wyndham Paducah in Paducah 5300 Old Cairo Rd., Paducah, KY 42001 Call ~27.64 miles east of Cairo
  • 3-star property
  • 74 sleeping rooms in hotel
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From$40
Poor 2.0 /5 Hotel Reviews Call BookMore Details
Courtyard by Marriott Cape Girardeau Downtown - Cape Girardeau 400 Broadway St., Cape Girardeau, MO 63701 Call ~27.65 miles northwest of Cairo
  • 3 star Downtown property
  • Fitness center on property
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From$80
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Drury Suites Paducah - Paducah 2930 James Sanders Blvd., Paducah, KY 42001 Call ~27.70 miles east of Cairo
  • 3-star Suburban property
  • Check-in time: 3:00 PM
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From$99
Very Good 4.0 /5 Review Score Call BookMore Details
Quality Suites Paducah I-24 : 2880 James Sanders Blvd. 2880 James Sanders Blvd., Paducah, KY 42001 Website Call ~27.73 miles east of Cairo
  • Economy Highway hotel
  • Fitness / Gym is on-site
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From$60
Average 3.0 /5 Review Score Call BookMore Details
Comfort Inn & Suites near Six Flags : 960 West Pointe Court 960 West Pointe Court, Lithia Springs, GA 30122 Website Call ~27.80 miles east of Cairo
  • Midscale Downtown hotel
  • 60 rooms in property
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From$70
Very Good 4.0 /5 Read Reviews Call BookMore Details
Garner Hotel Paducah West by IHG 145 Mcbride Lane, Paducah, KY 42001 Call ~27.80 miles east of Cairo
  • Affordable Highway property
  • 3 floors in hotel
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From$49
Very Good 4.0 /5 Review Score Call BookMore Details
Hotel 7 Inn Paducah in Paducah 5001 Hinkleville Rd., Paducah, KY 42001 Call ~27.81 miles east of Cairo
  • Low Cost hotel
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From$60
Average 3.0 /5 Read Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham Paducah in Paducah 3960 Coleman Crossing Cir, Paducah, KY 42001 Call ~27.90 miles east of Cairo
  • Affordable Highway property
  • Fitness + Health Center
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From$80
Average 3.0 /5 Review Score Call BookMore Details
Candlewood Suites Paducah by IHG 3940 Coleman Crossing Circle, Paducah, KY 42001 Call ~27.91 miles east of Cairo
  • 3-star Rural hotel
  • 85 suites in hotel
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From$60
Very Good 4.0 /5 Review Score Call BookMore Details
Homewood Suites by Hilton Paducah 3925 Coleman Crossing Cir, Paducah, KY 42001 Call ~27.94 miles east of Cairo
  • 3 star Highway hotel
  • 4 floors in property
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From$109
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Comfort Suites : 3918 Coleman Crossing Cir Paducah Ky 42001 3918 Coleman Crossing Cir Paducah Ky 42001, Paducah, KY 42001 Call ~27.96 miles east of Cairo
  • Low Cost Rural hotel
  • 72 suites in hotel
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From$60
Average 3.0 /5 Latest Reviews Call BookMore Details
Comfort Inn Paducah 5135 Cairo Rd., Paducah, KY 42001 Call ~27.98 miles east of Cairo
  • Midscale property
  • Access to gym on-site
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From$59
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Fairfield Inn & Suites by Marriott Paducah - Paducah 3950 Coleman Crossing Circle, Paducah, KY 42001 Call ~28.01 miles east of Cairo
  • 3-star Rural hotel
  • Hotel has 32 suites
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From$75
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Red Roof Inn Paducah 5106 Old Cairo Rd., Paducah, KY 42001 Call ~28.01 miles east of Cairo
  • Low priced property
  • Hotel has 8 suites
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From$45
Average 3.5 /5 Recent Reviews Call BookMore Details
American Inn 5125 Cairo Rd., Paducah, KY 42001 Call ~28.02 miles east of Cairo
  • Economical hotel
  • Check in time: 14:00
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From$37
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Hampton Inn & Suites Paducah in Paducah 3901 Coleman Crossing Circle, Paducah, KY 42001 Call ~28.02 miles east of Cairo
  • Affordable Highway hotel
  • Hotel has 108 rooms
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From$79
Very Good 4.5 /5 Read Reviews Call BookMore Details
Holiday Inn Express Hotel & Suites Paducah West by IHG 3996 Hinkleville Rd., Paducah, KY 42001 Call ~28.04 miles east of Cairo
  • Mid-scale Highway property
  • Complimentary breakfast is offered
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From$80
Average 3.0 /5 Review Score Call BookMore Details
Auburn Place Hotel & Suites - Paducah 3994 Hinkleville Rd., Paducah, KY 42001 Call ~28.05 miles east of Cairo
  • 3 star Airport property
  • Fitness / Gym is on-site
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From$80
Very Good 4.0 /5 Review Score Call BookMore Details
Courtyard by Marriott Paducah 3835 Technology Dr., Paducah, KY 42001 Call ~28.29 miles east of Cairo
  • 3 star Suburban property
  • 3 floors in property
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From$89
Very Good 4.0 /5 Read Reviews Call BookMore Details
Days Inn by Wyndham Paducah I-24 Exit 4 - Paducah 3901 Hinkleville Rd., Paducah, KY 42001 Call ~28.75 miles east of Cairo
  • Economical Highway property
  • Check-in time: 11:00 am
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From$50
Average 3.0 /5 Review Score Call BookMore Details
Candlewood Suites Cape Girardeau by IHG - Cape Girardeau 485 South Mount Auburn Rd., Cape Girardeau, MO 65703 Call ~28.76 miles northwest of Cairo
  • 2 star Highway property
  • Gym / Fitness Center Available
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From$69
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Travelers Inn and Suites - Paducah 2550 Lone Oak Rd., Paducah, KY 42003 Call ~28.88 miles east of Cairo
  • Inexpensive hotel
  • Airport shuttle available
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From$38
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Quality Inn & Suites Metropolis I-24 2118 East 5th St., Metropolis, IL 62960 Call ~28.88 miles east of Cairo
  • 3-star property
  • Check-in time: 11:00
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From$80
Very Good 4.0 /5 Review Score Call BookMore Details
Super 8 by Wyndham Metropolis 2055 East 5th St., Metropolis, IL 62960 Call ~28.89 miles east of Cairo
  • Economy Highway property
  • Check in: 02:00PM
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From$60
Average 3.0 /5 Recent Reviews Call BookMore Details
Motel 6 Metropolis Il in Metropolis 2119 East 5th St., Metropolis, IL 62960 Call ~29.04 miles east of Cairo
  • 2 star hotel
  • Check-in: 11:00 AM
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From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
Holiday Inn Express Metropolis by IHG 2179 East 5th St., Metropolis, IL 62960 Call ~29.10 miles east of Cairo
  • Mid-scale Rural property
  • 3 floors in property
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From$65
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Hampton Inn Cape Girardeau I 55 East : 207 South Mount Auburn Rd. 207 South Mount Auburn Rd., Cape Girardeau, MO 63703 Call ~29.41 miles northwest of Cairo
  • Three Star Highway property
  • Check in: 3:00 pm
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From$80
Excellent 5.0 /5 Read Reviews Call BookMore Details
Victorian Inn & Suites : 3256 William St. 3256 William St., Cape Girardeau, MO 63703 Call ~29.41 miles northwest of Cairo
  • 3-star Golf Course hotel
  • 2 meeting rooms in property
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From$79
Average 3.0 /5 Reviews Call BookMore Details
Auburn Place Hotel & Suites in Cape Girardeau 3265 Williams St., Cape Girardeau, MO 63702 Call ~29.42 miles northwest of Cairo
  • Mid-scale Highway property
  • Comp. Breakfast
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From$58
Very Good 4.5 /5 Reviews Call BookMore Details
Holiday Inn Express & Suites Cape Girardeau I 55 by Ihg in Cape Girardeau 3253 William St., Cape Girardeau, MO 63701 Call ~29.49 miles northwest of Cairo
  • 3 star property
  • 2 meeting rooms in hotel
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From$80
Very Good 4.5 /5 Recent Reviews Call BookMore Details
Fairfield Inn & Suites Cape Girardeau 433 Cape West Crossing, Cape Girardeay, MO 63703 Call ~29.58 miles northwest of Cairo
  • Midscale hotel
  • 103 sleeping rooms in hotel
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From$80
Average 3.0 /5 Recent Reviews Call BookMore Details
Drury Suites Cape Girardeau 3303 Campster Dr., Cape Girardeau, MO 63701 Call ~29.72 miles northwest of Cairo
  • Midscale Highway hotel
  • 5 floors in hotel
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From$85
Very Good 4.5 /5 Latest Reviews Call BookMore Details
Drury Lodge : 104 South Vantage Dr. 104 South Vantage Dr., Cape Girardeau, MO 63701 Call ~29.82 miles northwest of Cairo
  • Affordable Highway property
  • Check-in: 3:00pm
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From$80
Average 3.0 /5 Latest Reviews Call BookMore Details

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Verified reviews of the city: Cairo, IL

Below are reviews of the city of Cairo, IL from an actual visitor's perspective.

"Spending time with my family"
Score 5.0 / 5

Vincent R., from 26-Jan-2026
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