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Desoto Missouri Accommodations

Find hotels in Desoto using the list and search tools below. Search for the cheapest discounted hotel and motel rates in or near Desoto, MO for your corporate or personal leisure travel. We show the best Desoto Missouri hotel rooms. Review the Desoto hotel list below to find the perfect lodging. We also have a map of the Desoto hotels.

Desoto Hotels/Motels & Accommodations

Holiday Inn Club Vac Timber Creek : 4800 Us Highway 67 4800 Us Highway 67, Desoto, MO 63020
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  • Affordable property
  • Has environment-friendly policy See policy
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From£79 total
Very good 4.5 /5 Latest Reviews Call BookMore Details
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Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IH : 1802 Gamel Cemetery Rd. 1802 Gamel Cemetery Rd., Festus, MO 63028
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~9.28 miles northeast of Desoto
  • Economical Highway hotel
  • Access to gym on-site
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From£79 total
Very good 4.0 /5 Recent Reviews Call BookMore Details
Comfort Inn Festus - Festus 1303 Veterans Blvd., Festus, MO 63028 Website
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~9.48 miles northeast of Desoto
  • Mid-scale Suburban hotel
  • 5 suites in property
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From£70 total
Average 3.0 /5 Hotel Reviews Call BookMore Details
Baymont by Wyndham Festus : 1200 West Gannon Dr. 1200 West Gannon Dr., Festus, MO 63028
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~9.51 miles northeast of Desoto
  • Mid-scale Suburban hotel
  • 7 meeting rooms in hotel
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From£63 total
Average 3.0 /5 Guest Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham Festus - St. Louis South in Festus 1001 Veterans Blvd., Festus, MO 63028
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~9.70 miles northeast of Desoto
  • Midscale Suburban hotel
  • Check-in time: 3:00 PM
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From£70 total
Average 3.0 /5 Latest Reviews Call BookMore Details
Super 8 by Wyndham Pevely 1711 Highway Z, Pevely, MO 63070
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~13.03 miles northeast of Desoto
  • Economy property
  • Check-in time: 11:00 AM
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From£31 total
Very good 4.0 /5 Recent Reviews Call BookMore Details
Super 8 by Wyndham Bonne Terre 8 Northwood Dr., Bonne Terre, MO 63628
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~14.93 miles south of Desoto
  • Low priced hotel
  • Check-in time: 11:00 AM
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From£53 total
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Motel 6 Bonne Terre Mo 1017 Highway K, Bonne Terre, MO 63628
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~15.12 miles south of Desoto
  • Two star hotel
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From£53 total
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Super 8 by Wyndham Potosi : 820 East High St. 820 East High St., Potosi, MO 63664
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~18.89 miles southwest of Desoto
  • Low-priced Highway hotel
  • Hotel has 48 rooms
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From£43 total
Average 3.0 /5 Latest Reviews Call BookMore Details
Quality Inn & Suites - Arnold 3610 West Outer Rd., Arnold, MO 63010
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~20.97 miles northeast of Desoto
  • Two-star Suburban property
  • Hotel has an eco-friendly policy See more
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From£53 total
Average 3.0 /5 Reviews Call BookMore Details
Woodspring Suites St. Louis Arnold 888 Arnold Commons Dr., Arnold, MO 63010
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~22.46 miles northeast of Desoto
  • Two star Highway hotel
  • Check in time: 3 p.m.
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From£28 total
Very good 4.0 /5 Latest Reviews Call BookMore Details
Crown Pointe Lodge, BW Signature Collection 4245 Hunt Rd., Farmington, MO 63640
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~23.27 miles south of Desoto
  • 3 star Golf Course property
  • Has environment-friendly policy Read more
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From£54 total
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Best Western St. Louis Inn 6224 Heimos Industrial Park Dr., Saint Louis, MO 63129
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~24.42 miles northeast of Desoto
  • Cheap Suburban hotel
  • Check in: 03:00
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From£35 total
Average 3.0 /5 Review Score Call BookMore Details
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Hampton Inn Farmington in Farmington 850 Valley Creek Dr., Farmington, MO 63640
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~24.70 miles south of Desoto
  • Affordable Highway hotel
  • Fitness + Health Center
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From£70 total
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Super 8 by Wyndham Farmington : 930 Valley Creek Dr. 930 Valley Creek Dr., Farmington, MO 63640
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~24.77 miles south of Desoto
  • Inexpensive property
  • Complimentary breakfast is offered
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From£43 total
Average 3.0 /5 Read Reviews Call BookMore Details
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Holiday Inn Express & Suites Farmington by IHG - Farmington 820 Market St., Farmington, MO 63640
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~24.80 miles south of Desoto
  • Three Star Rural property
  • Check-in time: 3:00pm
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From£87 total
Very good 4.0 /5 Review Score Call BookMore Details
680 Fenton Business Park Ct Fenton Missouri 63026 : Fenton Business Park Court Fenton Fenton Business Park Court Fenton, Fenton, IA 63026
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~25.48 miles north of Desoto
  • 3-star property
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From£70 total
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Quality Inn Farmington in Farmington 1400 West Liberty St., Farmington, MO 63640
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~25.62 miles south of Desoto
  • Midscale Rural hotel
  • Check in: 11:00
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From£70 total
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America's Best Inn Eureka 1725 West 5th St., Eureka, MO 63025
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~25.87 miles north of Desoto
  • Inexpensive Highway property
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From£53 total
Poor 2.0 /5 Read Reviews Call BookMore Details
Super 8 by Wyndham Eureka/Six Flags Nearby 1733 West 5th St., Eureka, MO 63025
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~25.94 miles north of Desoto
  • 2 star Highway hotel
  • Free breakfast
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From£53 total
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Baymont Inn and Suites by Wyndham Farmington, MO in Farmington 1625 West Columbia St., Farmington, MO 63640
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~25.97 miles south of Desoto
  • Midscale Highway property
  • Hotel has 94 rooms
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From£70 total
Average 3.0 /5 Hotel Reviews Call BookMore Details
Fairfield Inn N Ste St. Louis South : 4318 Butler Hill Rd. 4318 Butler Hill Rd., St Louis, MO 63128
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~26.09 miles northeast of Desoto
  • Mid-scale property
  • 77 rooms in property
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From£79 total
Average 3.0 /5 Recent Reviews Call BookMore Details
Holiday Inn Express & Suites St. Louis South I 55 by IHG in St. Louis 4250 Midamerica Ln, St. Louis, MO 63129
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~26.13 miles northeast of Desoto
  • 3 star Suburban hotel
  • 99 rooms in property
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From£70 total
Average 3.0 /5 Review Score Call BookMore Details
Quality Inn Near Six Flags St. Louis 1400 West Osage St., Pacific, MO 63069
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~26.17 miles northwest of Desoto
  • 3-star Rural hotel
  • Free comp. breakfast
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From£70 total
Very good 4.0 /5 Latest Reviews Call BookMore Details
Hampton Inn & Suites St. Louis / South I 55 4200 Midamerica Ln, St. Louis, MO 63129
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~26.18 miles northeast of Desoto
  • 3 star Suburban property
  • Check-in: 3:00pm
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From£70 total
Very good 4.0 /5 Review Score Call BookMore Details
Comfort Inn Near Six Flags St. Louis 1320 Thornton St., Pacific, MO 63069
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~26.28 miles northwest of Desoto
  • Midscale Highway property
  • Access to gym on-site
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From£78 total
Average 3.0 /5 Guest Reviews Call BookMore Details
Holiday Inn St. Louis West Six Flags by IHG : 4901 Six Flags Rd. 4901 Six Flags Rd., Eureka, MO 63025
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~26.41 miles north of Desoto
  • Affordable Suburban property
  • Hotel has 3 floors
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From£114 total
Average 3.0 /5 Reviews Call BookMore Details
Super 8 by Wyndham Waterloo : 112 Warren Dr. 112 Warren Dr., Waterloo, IL 62298
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~26.68 miles northeast of Desoto
  • Inexpensive Rural hotel
  • Free comp. breakfast
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From£53 total
Average 3.5 /5 Read Reviews Call BookMore Details
Super 8 by Wyndham St. Clair MO : 1010 South Outer Rd. 1010 South Outer Rd., Saint Clair, MO 63077
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~27.53 miles northwest of Desoto
  • Two-star Highway property
  • Free breakfast available
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From£53 total
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Pinemark Inn & Suites 866 South Outer Rd., St. Clair, MO 63077
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~27.60 miles northwest of Desoto
  • Low-priced Highway hotel
  • 66 sleeping rooms in hotel
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From£54 total
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Hampton Inn St. Louis Southwest 9 Lambert Drury Place, St. Louis, MO 63088
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~27.66 miles north of Desoto
  • Midscale Suburban hotel
  • 92 sleeping rooms in hotel
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From£75 total
Very good 4.5 /5 Hotel Reviews Call BookMore Details
Hampton Inn St. Louis Columbia : 165 Admiral Trost Dr. 165 Admiral Trost Dr., Columbia, IL 62236
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~27.76 miles northeast of Desoto
  • Mid-scale Suburban hotel
  • 3 floors in hotel
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From£70 total
Average 3.0 /5 Latest Reviews Call BookMore Details
Holiday Inn Express & Suites St. Louis West - Fenton by IHG in Fenton 1848 Bowles Ave., Fenton, MO 63026
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~27.97 miles north of Desoto
  • Affordable Suburban property
  • Hotel has an eco-friendly policy Read more
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From£70 total
Very good 4.0 /5 Review Score Call BookMore Details
Motel 6 Fenton Mo 1860 Bowles Ave., Fenton, MO 63026
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~27.99 miles north of Desoto
  • 2 star property
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From£53 total
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Wingate by Wyndham St. Louis / Fenton Route 66 - Fenton 1100 South Highway Dr., Fenton, MO 63026
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~28.11 miles north of Desoto
  • 3-star Suburban property
  • Hotel has a green policy See policy
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From£70 total
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Heritage Inn & Suites St. Louis / Fenton Trademark by Wyndham 1088 South Highway Dr., Fenton, MO 63026
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~28.17 miles north of Desoto
  • Midscale Suburban hotel
  • Hotel has an eco-friendly policy Learn more
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From£70 total
Average 3.0 /5 Recent Reviews Call BookMore Details
Extended Stay America Suites St. Louis Fenton in Fenton 1662 Fenton Business Park Court, Fenton, MO 63026
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~28.25 miles north of Desoto
  • 3 star Suburban property
  • Check-in time: 3:00 pm
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From£70 total
Average 3.0 /5 Hotel Reviews Call BookMore Details
Americas Best Value Inn St. Louis South - St. Louis 6602 South Lindbergh Blvd., St. Louis, MO 63123
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~28.28 miles northeast of Desoto
  • Low priced Suburban hotel
  • Check in time: 3:00 PM
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From£43 total
Poor 2.0 /5 Recent Reviews Call BookMore Details
Best Western Plus Fenton 1680 Fenton Business Park Court, Fenton, MO 63026
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~28.32 miles north of Desoto
  • Three Star Suburban hotel
  • 3 floors in hotel
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From£54 total
Average 3.0 /5 Recent Reviews Call BookMore Details
Super 8 by Wyndham Fenton/St. Louis Area 650 South Highway Dr., Fenton, MO 63026
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~28.34 miles north of Desoto
  • Two star hotel
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From£53 total
Poor 2.0 /5 Review Score Call BookMore Details
Aviator Hotel & Suites : 6921 South Lindbergh Blvd. 6921 South Lindbergh Blvd., St Louis, MO 63125
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~28.36 miles northeast of Desoto
  • 3-star Suburban hotel
  • 149 rooms in property
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From£70 total
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Comfort Suites St. Louis : 3654 South Lindbergh Blvd. 3654 South Lindbergh Blvd., St. Louis, MO 63127
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~29.13 miles north of Desoto
  • Inexpensive Suburban property
  • Comp. Breakfast
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From£43 total
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Microtel Inn & Suites by Wyndham Sainte Genevieve 21958 State Highway 32, Ste. Genevieve, MO 63670
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~29.55 miles east of Desoto
  • Cheap Highway hotel
  • Check-in: 3:00 pm
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From£44 total
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Days Inn by Wyndham St. Louis Lindbergh Boulevard 3660 South Lindbergh Blvd., St Louis, MO 63127
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~29.61 miles north of Desoto
  • 3-star Suburban property
  • Hotel has 60 suites
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From£61 total
Average 3.0 /5 Latest Reviews Call BookMore Details
Holiday Inn St. Louis Sw Route 66 An Ihg Hotel - St. Louis 10709 Watson Rd., St. Louis, MO 63127
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~29.78 miles north of Desoto
  • Mid-scale Suburban hotel
  • 12 suites in property
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From£70 total
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La Quinta Inn & Suites by Wyndham - Saint Louis 1580 South Kirkwood Rd., Saint Louis, MO 63127
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~29.85 miles north of Desoto
  • Mid-scale Suburban hotel
  • 84 rooms in property
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From£88 total
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Best Western St. Louis-Kirkwood Route 66 1200 South Kirkwood Rd., Saint Louis, MO 63122
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~30.29 miles north of Desoto
  • 3 star Suburban hotel
  • Gym / Fitness Center Available
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From£62 total
Very good 4.0 /5 Review Score Call BookMore Details
The Wildwood Hotel in Wildwood 2801 Fountain Place, Wildwood, MO 63040
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~30.75 miles north of Desoto
  • High-end Suburban property
  • Fitness center on property
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From£88 total
Very good 4.0 /5 Read Reviews Call BookMore Details
Super 8 by Wyndham Union 1015 East Main St., Union, MO 63084
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~31.92 miles northwest of Desoto
  • Low priced Rural hotel
  • Free breakfast available
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From£59 total
Average 3.0 /5 Latest Reviews Call BookMore Details
Courtyard by Marriott St. Louis West County in St. Louis 12815a Daylight Dr., St. Louis, MO 63131 Website
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~32.70 miles north of Desoto
  • 3 star Suburban hotel
  • 110 sleeping rooms in hotel
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From£70 total
Very good 4.0 /5 Read Reviews Call BookMore Details

Next: See My Desoto Hotels with Pricing

Graph: Upcoming 20 Days of Desoto Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Desoto, MO discounts available. The chart reflects the cheapest Desoto hotel for each day and each star rating category.

FAQs about hotels in Desoto

What are the top rated hotels in Desoto?

Holiday Inn Club Vac Timber Creek, Hampton Inn St. Louis Southwest and Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IH are the best rated hotels based on customer reviews in the last 365 days.

What are the most high-end hotels in Desoto?

The Wildwood Hotel, Holiday Inn Club Vac Timber Creek and Comfort Inn Festus are the top 3 luxury hotels near Desoto city center.

What hotels are closest to the city center of Desoto?

Holiday Inn Club Vac Timber Creek, Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IH, and Comfort Inn Festus are the properties closest to Desoto city center.

What are the most popular independent hotels in Desoto?

Pinemark Inn & Suites, The Wildwood Hotel and America's Best Inn Eureka are the best rated independent hotels (not part of a big brand).

What are the most popular Marriott hotels in Desoto?

Courtyard by Marriott St. Louis West County and Fairfield Inn N Ste St. Louis South are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the best Choice Hotels branded hotels in Desoto?

Woodspring Suites St. Louis Arnold, Quality Inn Near Six Flags St. Louis and Comfort Suites St. Louis are the best rated Choice Hotels branded hotels (based on HotelPlanner reviews score).

What are the most popular Best Western hotels in Desoto?

Crown Pointe Lodge, BW Signature Collection, Best Western St. Louis-Kirkwood Route 66 and Best Western St. Louis Inn are the best rated Best Western branded hotels (based on user reviews score).

What are the most popular IHG hotels in Desoto?

Holiday Inn Club Vac Timber Creek, Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IH and Holiday Inn Express & Suites Farmington by IHG are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

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