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Desoto Missouri Accommodations

Find hotels in Desoto using the list and search tools below. Search for the cheapest discounted hotel and motel rates in or near Desoto, MO for your corporate or personal leisure travel. We show the best Desoto Missouri hotel rooms. Review the Desoto hotel list below to find the perfect lodging. We also have a map of the Desoto hotels.

Desoto Hotels & Accommodations

Holiday Inn Club Vac Timber Creek in Desoto 4800 Us Highway 67, Desoto, MO 63020
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  • 3-star hotel
  • 3 floors in property
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From£66
Very good 4.5 /5 Review Score Call BookMore Details
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Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IH : 1802 Gamel Cemetery Rd. 1802 Gamel Cemetery Rd., Festus, MO 63028
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~9.28 miles northeast of Desoto
  • Low priced Highway property
  • Comp. Breakfast
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From£66
Very good 4.0 /5 Latest Reviews Call BookMore Details
Comfort Inn Festus St. Louis South : 1303 Veterans Blvd. 1303 Veterans Blvd., Festus, MO 63028 Website
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~9.48 miles northeast of Desoto
  • 3-star Suburban hotel
  • 5 suites in hotel
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From£33
Very good 4.0 /5 Read Reviews Call BookMore Details
Baymont by Wyndham Festus in Festus 1200 West Gannon Dr., Festus, MO 63028
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~9.51 miles northeast of Desoto
  • Mid-scale Suburban hotel
  • 134 rooms in hotel
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From£53
Average 3.0 /5 Latest Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham Festus - St. Louis South : 1001 Veterans Blvd. 1001 Veterans Blvd., Festus, MO 63028
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~9.70 miles northeast of Desoto
  • Affordable Suburban hotel
  • Access to gym on-site
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From£59
Average 3.0 /5 Read Reviews Call BookMore Details
Super 8 by Wyndham Pevely - Pevely 1711 Highway Z, Pevely, MO 63070
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~13.03 miles northeast of Desoto
  • 2 star property
  • Check-in time: 11:00 AM
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From£25
Very good 4.0 /5 Read Reviews Call BookMore Details
Super 8 by Wyndham Bonne Terre 8 Northwood Dr., Bonne Terre, MO 63628
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~14.93 miles south of Desoto
  • 2 star property
  • Check in: 11:00 AM
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From£44
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Motel 6 Bonne Terre Mo 1017 Highway K, Bonne Terre, MO 63628
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~15.12 miles south of Desoto
  • Economical hotel
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From£44
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Super 8 by Wyndham Potosi 820 East High St., Potosi, MO 63664
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~18.89 miles southwest of Desoto
  • Cheap Highway hotel
  • 48 sleeping rooms in hotel
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From£36
Average 3.0 /5 Review Score Call BookMore Details
Quality Inn & Suites 3610 West Outer Rd., Arnold, MO 63010 Website
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~20.97 miles northeast of Desoto
  • Cheap Suburban property
  • Free breakfast available
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From£44
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Woodspring Suites St. Louis Arnold in Arnold 888 Arnold Commons Dr., Arnold, MO 63010
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~22.46 miles northeast of Desoto
  • Cheap Highway hotel
  • 124 sleeping rooms in hotel
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From£23
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Drury Inn & Suites St. Louis Arnold 3800 State Rt 141, Arnold, MO 63010
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~22.57 miles northeast of Desoto
  • Affordable Suburban hotel
  • Hotel has 15 suites
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From£91
Excellent 5.0 /5 Review Score Call BookMore Details
Pear Tree Inn St. Louis Arnold in Arnold 1201 Drury Lane, Arnold, MO 63010
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~23.16 miles northeast of Desoto
  • Mid-scale Suburban property
  • Has environment-friendly policy Learn more
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From£59
Very good 4.0 /5 Reviews Call BookMore Details
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Crown Pointe Lodge, BW Signature Collection - Farmington 4245 Hunt Rd., Farmington, MO 63640
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~23.27 miles south of Desoto
  • Three Star Golf Course hotel
  • Hotel has 17 suites
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From£47
Very good 4.0 /5 Review Score Call BookMore Details
Best Western St. Louis Inn 6224 Heimos Industrial Park Dr., Saint Louis, MO 63129
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~24.42 miles northeast of Desoto
  • Economy Suburban hotel
  • Check-in: 03:00
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From£30
Average 3.0 /5 Reviews Call BookMore Details
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Hampton Inn Farmington - Farmington 850 Valley Creek Dr., Farmington, MO 63640
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~24.70 miles south of Desoto
  • 3-star Highway hotel
  • Gym is available on property
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From£59
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Super 8 by Wyndham Farmington in Farmington 930 Valley Creek Dr., Farmington, MO 63640
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~24.77 miles south of Desoto
  • Cheap hotel
  • Check in: 3:00 pm
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From£36
Average 3.0 /5 Review Score Call BookMore Details
Holiday Inn Express & Suites Farmington by IHG 820 Market St., Farmington, MO 63640
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~24.80 miles south of Desoto
  • Mid-scale Rural hotel
  • Check-in time: 3:00pm
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From£73
Very good 4.0 /5 Latest Reviews Call BookMore Details
680 Fenton Business Park Ct Fenton Missouri 63026 Fenton Business Park Court Fenton, Fenton, IA 63026
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~25.48 miles north of Desoto
  • 3 star property
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From£59
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Quality Inn Farmington : 1400 West Liberty St. 1400 West Liberty St., Farmington, MO 63640
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~25.62 miles south of Desoto
  • 3 star Rural property
  • Check-in time: 11:00
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From£59
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America's Best Inn Eureka : 1725 West 5th St. 1725 West 5th St., Eureka, MO 63025
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~25.87 miles north of Desoto
  • Cheap Highway property
  • Check in: 11.00am
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From£44
Poor 2.0 /5 Latest Reviews Call BookMore Details
Super 8 by Wyndham Eureka/Six Flags Nearby 1733 West 5th St., Eureka, MO 63025
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~25.94 miles north of Desoto
  • Inexpensive Highway hotel
  • Comp. Breakfast
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From£44
Average 3.0 /5 Reviews Call BookMore Details
Baymont Inn and Suites by Wyndham Farmington, MO 1625 West Columbia St., Farmington, MO 63640
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~25.97 miles south of Desoto
  • Midscale Highway property
  • 2 suites in property
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From£59
Average 3.0 /5 Review Score Call BookMore Details
Fairfield Inn N Ste St. Louis South in St Louis 4318 Butler Hill Rd., St Louis, MO 63128
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~26.09 miles northeast of Desoto
  • 3 star hotel
  • 77 rooms in property
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From£66
Average 3.0 /5 Latest Reviews Call BookMore Details
Holiday Inn Express & Suites St. Louis South I 55 by IHG 4250 Midamerica Ln, St. Louis, MO 63129
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~26.13 miles northeast of Desoto
  • 3-star Suburban hotel
  • Check in time: 3p
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From£59
Average 3.0 /5 Latest Reviews Call BookMore Details
Quality Inn Near Six Flags St. Louis : 1400 West Osage St. 1400 West Osage St., Pacific, MO 63069
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~26.17 miles northwest of Desoto
  • 3 star Rural property
  • Hotel has 46 rooms
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From£59
Very good 4.0 /5 Review Score Call BookMore Details
Hampton Inn & Suites St. Louis/South I-55 - St. Louis 4200 Midamerica Ln, St. Louis, MO 63129
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~26.18 miles northeast of Desoto
  • 3-star Suburban property
  • 33 suites in property
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From£59
Very good 4.0 /5 Reviews Call BookMore Details
Comfort Inn Near Six Flags St. Louis - Pacific 1320 Thornton St., Pacific, MO 63069 Website
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~26.28 miles northwest of Desoto
  • 3-star Highway hotel
  • 70 rooms in property
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From£65
Average 3.0 /5 Hotel Reviews Call BookMore Details
Holiday Inn St. Louis West Six Flags by IHG 4901 Six Flags Rd., Eureka, MO 63025
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~26.41 miles north of Desoto
  • 3 star Suburban hotel
  • 11 suites in property
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From£95
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Super 8 by Wyndham Waterloo - Waterloo 112 Warren Dr., Waterloo, IL 62298
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~26.68 miles northeast of Desoto
  • Two-star Rural property
  • Complimentary breakfast is offered
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From£44
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Super 8 by Wyndham St. Clair MO : 1010 South Outer Rd. 1010 South Outer Rd., Saint Clair, MO 63077
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~27.53 miles northwest of Desoto
  • 2 star Highway hotel
  • 51 rooms in property
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From£44
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Pinemark Inn & Suites : 866 South Outer Rd. 866 South Outer Rd., St. Clair, MO 63077
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~27.60 miles northwest of Desoto
  • 2 star Highway property
  • Hotel has 2 meeting rooms
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From£45
Very good 4.0 /5 Read Reviews Call BookMore Details
Hampton Inn St. Louis Southwest 9 Lambert Drury Place, St. Louis, MO 63088
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~27.66 miles north of Desoto
  • 3 star Suburban hotel
  • 4 floors in property
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From£63
Very good 4.5 /5 Guest Reviews Call BookMore Details
Drury Inn & Suites St. Louis Southwest : 5 Lambert Drury Place (I 44 & 141) 5 Lambert Drury Place (I 44 & 141), St. Louis, MO 63088
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~27.66 miles north of Desoto
  • Midscale Suburban property
  • Hotel has 30 suites
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From£62
Very good 4.5 /5 Review Score Call BookMore Details
Hampton Inn St. Louis Columbia 165 Admiral Trost Dr., Columbia, IL 62236
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~27.76 miles northeast of Desoto
  • Affordable Suburban property
  • Free complimentary breakfast
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From£59
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Holiday Inn Express & Suites St. Louis West - Fenton by IHG 1848 Bowles Ave., Fenton, MO 63026
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~27.97 miles north of Desoto
  • 3-star Suburban hotel
  • 76 rooms in property
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From£59
Very good 4.0 /5 Recent Reviews Call BookMore Details
Motel 6 Fenton Mo : 1860 Bowles Ave. 1860 Bowles Ave., Fenton, MO 63026
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~27.99 miles north of Desoto
  • Low-priced property
  • 58 sleeping rooms in hotel
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From£44
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Wingate by Wyndham St. Louis / Fenton Route 66 - Fenton 1100 South Highway Dr., Fenton, MO 63026
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~28.11 miles north of Desoto
  • Mid-scale Suburban property
  • Hotel has a green policy Read more
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From£59
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Heritage Inn & Suites St. Louis / Fenton Trademark by Wyndham 1088 South Highway Dr., Fenton, MO 63026
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~28.17 miles north of Desoto
  • 3-star Suburban hotel
  • 139 rooms in property
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From£59
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Extended Stay America Suites St. Louis Fenton : 1662 Fenton Business Park Court 1662 Fenton Business Park Court, Fenton, MO 63026
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~28.25 miles north of Desoto
  • Affordable Suburban hotel
  • Check in: 3:00 pm
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From£59
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Americas Best Value Inn St. Louis South 6602 South Lindbergh Blvd., St. Louis, MO 63123
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~28.28 miles northeast of Desoto
  • Economical Suburban property
  • 3 floors in hotel
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From£36
Poor 2.0 /5 Guest Reviews Call BookMore Details
Best Western Plus Fenton : 1680 Fenton Business Park Court 1680 Fenton Business Park Court, Fenton, MO 63026
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~28.32 miles north of Desoto
  • Three Star Suburban property
  • Check in: 03:00
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From£47
Average 3.0 /5 Recent Reviews Call BookMore Details
Super 8 by Wyndham Fenton/St. Louis Area - Fenton 650 South Highway Dr., Fenton, MO 63026
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~28.34 miles north of Desoto
  • Low priced hotel
  • Check in time: 15:00
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From£44
Poor 2.0 /5 Latest Reviews Call BookMore Details
Aviator Hotel & Suites : 6921 South Lindbergh Blvd. 6921 South Lindbergh Blvd., St Louis, MO 63125
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~28.36 miles northeast of Desoto
  • 3-star Suburban property
  • 4 floors in hotel
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From£59
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Comfort Suites St. Louis : 3654 South Lindbergh Blvd. 3654 South Lindbergh Blvd., St. Louis, MO 63127
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~29.13 miles north of Desoto
  • Two star Suburban property
  • 160 sleeping rooms in hotel
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From£36
Average 3.5 /5 Review Score Call BookMore Details
Microtel Inn & Suites by Wyndham Sainte Genevieve : 21958 State Highway 32 21958 State Highway 32, Ste. Genevieve, MO 63670
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~29.55 miles east of Desoto
  • Low priced Highway hotel
  • Check in time: 3:00 pm
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From£37
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Days Inn by Wyndham St. Louis Lindbergh Boulevard 3660 South Lindbergh Blvd., St Louis, MO 63127
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~29.61 miles north of Desoto
  • 3 star Suburban hotel
  • Hotel has 60 suites
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From£51
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Holiday Inn St. Louis Sw Route 66 An Ihg Hotel 10709 Watson Rd., St. Louis, MO 63127
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~29.78 miles north of Desoto
  • 3-star Suburban property
  • Check-in: 4:00 PM
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From£58
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La Quinta Inn & Suites by Wyndham - Saint Louis 1580 South Kirkwood Rd., Saint Louis, MO 63127
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~29.85 miles north of Desoto
  • Affordable Suburban property
  • Comp. Breakfast
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From£74
Average 3.0 /5 Recent Reviews Call BookMore Details
Best Western St. Louis-Kirkwood Route 66 1200 South Kirkwood Rd., Saint Louis, MO 63122
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~30.29 miles north of Desoto
  • Mid-scale Suburban property
  • Complimentary breakfast is offered
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From£51
Very good 4.0 /5 Guest Reviews Call BookMore Details

Next: See My Desoto Hotels with Pricing

Graph: Upcoming 20 Days of Desoto Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Desoto, MO discounts available. The chart reflects the cheapest Desoto hotel for each day and each star rating category.

FAQs about hotels in Desoto

What are the top reviewed hotels in Desoto?

Drury Inn & Suites St. Louis Arnold, Holiday Inn Club Vac Timber Creek and Hampton Inn St. Louis Southwest are the best rated hotels based on customer reviews in the last 365 days.

What are the top luxurious hotels in Desoto?

Holiday Inn Club Vac Timber Creek, Comfort Inn Festus St. Louis South and Baymont by Wyndham Festus are the top 3 luxury hotels near Desoto city center.

What hotels are closest to the city center of Desoto?

Holiday Inn Club Vac Timber Creek, Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IH, and Comfort Inn Festus St. Louis South are the properties closest to Desoto city center.

What are the most popular independent hotels in Desoto?

Pinemark Inn & Suites, America's Best Inn Eureka and 680 Fenton Business Park Ct Fenton Missouri 63026 are the best rated independent hotels (not part of a big brand).

What are the most popular Choice Hotels branded hotels in Desoto?

Comfort Inn Festus St. Louis South, Woodspring Suites St. Louis Arnold and Quality Inn Near Six Flags St. Louis are the best rated Choice Hotels branded hotels (based on HotelPlanner reviews score).

What are the most popular Best Western hotels in Desoto?

Crown Pointe Lodge, BW Signature Collection, Best Western St. Louis-Kirkwood Route 66 and Best Western St. Louis Inn are the best rated Best Western branded hotels (based on user reviews score).

What are the most popular IHG hotels in Desoto?

Holiday Inn Club Vac Timber Creek, Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IH and Holiday Inn Express & Suites Farmington by IHG are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

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