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Desoto Missouri Accommodations

Find hotels in Desoto using the list and search tools below. Search for the cheapest discounted hotel and motel rates in or near Desoto, MO for your corporate or personal leisure travel. We show the best Desoto Missouri hotel rooms. Review the Desoto hotel list below to find the perfect lodging. We also have a map of the Desoto hotels.

Desoto Hotels/Motels & Accommodations

Holiday Inn Club Vac Timber Creek - Desoto 4800 Us Highway 67, Desoto, MO 63020
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  • Midscale property
  • Check in: 16:00
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From£81 total
Very good 4.5 /5 Reviews Call BookMore Details
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Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IH - Festus 1802 Gamel Cemetery Rd., Festus, MO 63028
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~9.28 miles northeast of Desoto
  • 2 star Highway property
  • Hotel has 4 floors
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From£81 total
Very good 4.0 /5 Recent Reviews Call BookMore Details
Comfort Inn Festus 1303 Veterans Blvd., Festus, MO 63028 Website
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~9.48 miles northeast of Desoto
  • Three Star Suburban property
  • 89 sleeping rooms in hotel
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From£72 total
Average 3.0 /5 Recent Reviews Call BookMore Details
Baymont by Wyndham Festus : 1200 West Gannon Dr. 1200 West Gannon Dr., Festus, MO 63028
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~9.51 miles northeast of Desoto
  • Mid-scale Suburban property
  • 134 rooms in hotel
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From£65 total
Average 3.0 /5 Hotel Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham Festus - St. Louis South 1001 Veterans Blvd., Festus, MO 63028
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~9.70 miles northeast of Desoto
  • 3 star Suburban hotel
  • Complimentary breakfast is offered
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From£72 total
Average 3.0 /5 Review Score Call BookMore Details
Super 8 by Wyndham Pevely in Pevely 1711 Highway Z, Pevely, MO 63070
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~13.03 miles northeast of Desoto
  • Low priced property
  • Check in time: 11:00 AM
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From£31 total
Very good 4.0 /5 Reviews Call BookMore Details
Super 8 by Wyndham Bonne Terre 8 Northwood Dr., Bonne Terre, MO 63628
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~14.93 miles south of Desoto
  • Inexpensive property
  • Check-in time: 11:00 AM
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From£54 total
Average 3.0 /5 Review Score Call BookMore Details
Motel 6 Bonne Terre Mo in Bonne Terre 1017 Highway K, Bonne Terre, MO 63628
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~15.12 miles south of Desoto
  • Cheap hotel
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From£54 total
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Super 8 by Wyndham Potosi - Potosi 820 East High St., Potosi, MO 63664
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~18.89 miles southwest of Desoto
  • Cheap Highway property
  • Hotel has 48 rooms
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From£44 total
Average 3.0 /5 Review Score Call BookMore Details
Quality Inn & Suites 3610 West Outer Rd., Arnold, MO 63010
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~20.97 miles northeast of Desoto
  • Two-star Suburban hotel
  • Gym is available on property
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From£54 total
Average 3.0 /5 Latest Reviews Call BookMore Details
Woodspring Suites St. Louis Arnold 888 Arnold Commons Dr., Arnold, MO 63010
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~22.46 miles northeast of Desoto
  • Two star Highway hotel
  • 124 sleeping rooms in hotel
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From£28 total
Very good 4.0 /5 Review Score Call BookMore Details
Crown Pointe Lodge, BW Signature Collection : 4245 Hunt Rd. 4245 Hunt Rd., Farmington, MO 63640
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~23.27 miles south of Desoto
  • Three Star Golf Course hotel
  • 48 rooms in property
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From£57 total
Very good 4.0 /5 Recent Reviews Call BookMore Details
Best Western St. Louis Inn - Saint Louis 6224 Heimos Industrial Park Dr., Saint Louis, MO 63129
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~24.42 miles northeast of Desoto
  • 2 star Suburban property
  • Check in time: 03:00
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From£37 total
Average 3.0 /5 Latest Reviews Call BookMore Details
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Hampton Inn Farmington : 850 Valley Creek Dr. 850 Valley Creek Dr., Farmington, MO 63640
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~24.70 miles south of Desoto
  • Three Star Highway property
  • Comp. Breakfast
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From£72 total
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Super 8 by Wyndham Farmington in Farmington 930 Valley Creek Dr., Farmington, MO 63640
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~24.77 miles south of Desoto
  • Low-priced property
  • Check in time: 3:00 pm
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From£44 total
Average 3.0 /5 Read Reviews Call BookMore Details
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Holiday Inn Express & Suites Farmington by IHG in Farmington 820 Market St., Farmington, MO 63640
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~24.80 miles south of Desoto
  • 3 star Rural property
  • Hotel has 3 floors
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From£89 total
Very good 4.0 /5 Latest Reviews Call BookMore Details
680 Fenton Business Park Ct Fenton Missouri 63026 Fenton Business Park Court Fenton, Fenton, IA 63026
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~25.48 miles north of Desoto
  • 3-star hotel
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From£72 total
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Quality Inn Farmington 1400 West Liberty St., Farmington, MO 63640
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~25.62 miles south of Desoto
  • Affordable Rural hotel
  • Check-in: 11:00
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From£72 total
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America's Best Inn Eureka : 1725 West 5th St. 1725 West 5th St., Eureka, MO 63025
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~25.87 miles north of Desoto
  • Cheap Highway hotel
  • Check in time: 11.00am
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From£54 total
Poor 2.0 /5 Reviews Call BookMore Details
Super 8 by Wyndham Eureka/Six Flags Nearby 1733 West 5th St., Eureka, MO 63025
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~25.94 miles north of Desoto
  • Economy Highway property
  • Free breakfast available
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From£54 total
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Baymont Inn and Suites by Wyndham Farmington, MO in Farmington 1625 West Columbia St., Farmington, MO 63640
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~25.97 miles south of Desoto
  • 3-star Highway hotel
  • Check in time: 04:00
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From£72 total
Average 3.0 /5 Latest Reviews Call BookMore Details
Fairfield Inn N Ste St. Louis South : 4318 Butler Hill Rd. 4318 Butler Hill Rd., St Louis, MO 63128
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~26.09 miles northeast of Desoto
  • Three Star property
  • 77 rooms in property
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From£81 total
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Holiday Inn Express & Suites St. Louis South I 55 by IHG : 4250 Midamerica Ln 4250 Midamerica Ln, St. Louis, MO 63129
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~26.13 miles northeast of Desoto
  • Mid-scale Suburban property
  • Check-in: 3p
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From£72 total
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Quality Inn Near Six Flags St. Louis in Pacific 1400 West Osage St., Pacific, MO 63069
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~26.17 miles northwest of Desoto
  • Affordable Rural property
  • 46 rooms in hotel
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From£72 total
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Hampton Inn & Suites St. Louis/South I-55 4200 Midamerica Ln, St. Louis, MO 63129
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~26.18 miles northeast of Desoto
  • Affordable Suburban hotel
  • Fitness / Gym is on-site
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From£72 total
Very good 4.0 /5 Latest Reviews Call BookMore Details
Comfort Inn Near Six Flags St. Louis in Pacific 1320 Thornton St., Pacific, MO 63069
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~26.28 miles northwest of Desoto
  • Midscale Highway hotel
  • Hotel has 2 suites
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From£79 total
Average 3.0 /5 Guest Reviews Call BookMore Details
Holiday Inn St. Louis West Six Flags by IHG 4901 Six Flags Rd., Eureka, MO 63025
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~26.41 miles north of Desoto
  • Midscale Suburban property
  • Hotel has 3 floors
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From£116 total
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Super 8 by Wyndham Waterloo : 112 Warren Dr. 112 Warren Dr., Waterloo, IL 62298
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~26.68 miles northeast of Desoto
  • Cheap Rural property
  • Check in time: 3:00 PM
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From£54 total
Average 3.5 /5 Latest Reviews Call BookMore Details
Super 8 by Wyndham St. Clair MO : 1010 South Outer Rd. 1010 South Outer Rd., Saint Clair, MO 63077
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~27.53 miles northwest of Desoto
  • Low priced Highway hotel
  • Check-in time: 3 PM
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From£54 total
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Pinemark Inn & Suites in St. Clair 866 South Outer Rd., St. Clair, MO 63077
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~27.60 miles northwest of Desoto
  • Two-star Highway hotel
  • Free complimentary breakfast
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From£55 total
Very good 4.0 /5 Reviews Call BookMore Details
Hampton Inn St. Louis Southwest : 9 Lambert Drury Place 9 Lambert Drury Place, St. Louis, MO 63088
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~27.66 miles north of Desoto
  • Mid-scale Suburban property
  • Hotel has 4 floors
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From£76 total
Very good 4.5 /5 Guest Reviews Call BookMore Details
Hampton Inn St. Louis Columbia 165 Admiral Trost Dr., Columbia, IL 62236
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~27.76 miles northeast of Desoto
  • 3-star Suburban hotel
  • 3 floors in property
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From£72 total
Average 3.0 /5 Reviews Call BookMore Details
Holiday Inn Express & Suites St. Louis West - Fenton by IHG 1848 Bowles Ave., Fenton, MO 63026
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~27.97 miles north of Desoto
  • Mid-scale Suburban hotel
  • Check in time: 03:00 PM
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From£72 total
Very good 4.0 /5 Read Reviews Call BookMore Details
Motel 6 Fenton Mo in Fenton 1860 Bowles Ave., Fenton, MO 63026
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~27.99 miles north of Desoto
  • Low-priced property
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From£54 total
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Wingate by Wyndham St. Louis / Fenton Route 66 1100 South Highway Dr., Fenton, MO 63026
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~28.11 miles north of Desoto
  • Midscale Suburban property
  • Check in: 3:00 PM
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From£72 total
Average 3.0 /5 Recent Reviews Call BookMore Details
Heritage Inn & Suites St. Louis / Fenton Trademark by Wyndham 1088 South Highway Dr., Fenton, MO 63026
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~28.17 miles north of Desoto
  • Midscale Suburban hotel
  • Hotel has 139 rooms
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From£72 total
Average 3.0 /5 Recent Reviews Call BookMore Details
Extended Stay America Suites St. Louis Fenton 1662 Fenton Business Park Court, Fenton, MO 63026
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~28.25 miles north of Desoto
  • 3 star Suburban property
  • Check in: 3:00 pm
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From£72 total
Average 3.0 /5 Review Score Call BookMore Details
Americas Best Value Inn St. Louis South in St. Louis 6602 South Lindbergh Blvd., St. Louis, MO 63123
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~28.28 miles northeast of Desoto
  • Economy Suburban property
  • Free breakfast available
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From£44 total
Poor 2.0 /5 Hotel Reviews Call BookMore Details
Best Western Plus Fenton : 1680 Fenton Business Park Court 1680 Fenton Business Park Court, Fenton, MO 63026
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~28.32 miles north of Desoto
  • 3 star Suburban hotel
  • 3 floors in property
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From£57 total
Average 3.0 /5 Latest Reviews Call BookMore Details
Super 8 by Wyndham Fenton/St. Louis Area - Fenton 650 South Highway Dr., Fenton, MO 63026
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~28.34 miles north of Desoto
  • Low Cost property
  • Check in: 15:00
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From£54 total
Poor 2.0 /5 Review Score Call BookMore Details
Aviator Hotel & Suites : 6921 South Lindbergh Blvd. 6921 South Lindbergh Blvd., St Louis, MO 63125
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~28.36 miles northeast of Desoto
  • Affordable Suburban hotel
  • 8 meeting rooms in property
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From£72 total
Average 3.0 /5 Review Score Call BookMore Details
Comfort Suites St. Louis 3654 South Lindbergh Blvd., St. Louis, MO 63127
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~29.13 miles north of Desoto
  • Economy Suburban property
  • 3 conference rooms in property
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From£44 total
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Microtel Inn & Suites by Wyndham Sainte Genevieve 21958 State Highway 32, Ste. Genevieve, MO 63670
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~29.55 miles east of Desoto
  • Low-priced Highway hotel
  • Hotel has 2 floors
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From£45 total
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Days Inn by Wyndham St. Louis Lindbergh Boulevard - St Louis 3660 South Lindbergh Blvd., St Louis, MO 63127
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~29.61 miles north of Desoto
  • 3-star Suburban property
  • 116 rooms in property
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From£62 total
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Holiday Inn St. Louis Sw Route 66 An Ihg Hotel 10709 Watson Rd., St. Louis, MO 63127
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~29.78 miles north of Desoto
  • Midscale Suburban property
  • Check in: 4:00 PM
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From£71 total
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La Quinta Inn & Suites by Wyndham 1580 South Kirkwood Rd., Saint Louis, MO 63127
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~29.85 miles north of Desoto
  • 3-star Suburban property
  • 3 floors in property
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From£90 total
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Best Western St. Louis-Kirkwood Route 66 - Saint Louis 1200 South Kirkwood Rd., Saint Louis, MO 63122
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~30.29 miles north of Desoto
  • 3 star Suburban hotel
  • 6 floors in hotel
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From£63 total
Very good 4.0 /5 Latest Reviews Call BookMore Details
The Wildwood Hotel 2801 Fountain Place, Wildwood, MO 63040
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~30.75 miles north of Desoto
  • High-end Suburban property
  • 6 conference rooms in property
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From£90 total
Very good 4.0 /5 Latest Reviews Call BookMore Details
Super 8 by Wyndham Union - Union 1015 East Main St., Union, MO 63084
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~31.92 miles northwest of Desoto
  • Economical Rural property
  • Comp. Breakfast
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From£60 total
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Courtyard by Marriott St. Louis West County 12815a Daylight Dr., St. Louis, MO 63131 Website
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~32.70 miles north of Desoto
  • Three Star Suburban hotel
  • 110 sleeping rooms in hotel
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From£71 total
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Next: See My Desoto Hotels with Pricing

Graph: Upcoming 20 Days of Desoto Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Desoto, MO discounts available. The chart reflects the cheapest Desoto hotel for each day and each star rating category.

FAQs about hotels in Desoto

What are the top rated hotels in Desoto?

Holiday Inn Club Vac Timber Creek, Hampton Inn St. Louis Southwest and Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IH are the best rated hotels based on customer reviews in the last 365 days.

What are the most high-end hotels in Desoto?

The Wildwood Hotel, Holiday Inn Club Vac Timber Creek and Comfort Inn Festus are the top 3 luxury hotels near Desoto city center.

What hotels are closest to the city center of Desoto?

Holiday Inn Club Vac Timber Creek, Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IH, and Comfort Inn Festus are the properties closest to Desoto city center.

What are the most popular independent hotels in Desoto?

Pinemark Inn & Suites, The Wildwood Hotel and America's Best Inn Eureka are the best rated independent hotels (not part of a big brand).

What are the most popular Marriott hotels in Desoto?

Courtyard by Marriott St. Louis West County and Fairfield Inn N Ste St. Louis South are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the best Choice Hotels branded hotels in Desoto?

Woodspring Suites St. Louis Arnold, Quality Inn Near Six Flags St. Louis and Comfort Suites St. Louis are the best rated Choice Hotels branded hotels (based on HotelPlanner reviews score).

What are the most popular Best Western hotels in Desoto?

Crown Pointe Lodge, BW Signature Collection, Best Western St. Louis-Kirkwood Route 66 and Best Western St. Louis Inn are the best rated Best Western branded hotels (based on user reviews score).

What are the most popular IHG hotels in Desoto?

Holiday Inn Club Vac Timber Creek, Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IH and Holiday Inn Express & Suites Farmington by IHG are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

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