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Cairo Illinois Accommodations

Find hotels & motels in Cairo using the list below. Search for cheap and discounted hotel and motel rates in or close to Cairo, IL for your upcoming individual or group travel. Discover the best Cairo Illinois hotel/motel rooms. Review the Cairo hotel list below to find the perfect lodging. We also have a map of the Cairo hotels.

Cairo Hotels, Motels & Accommodations

Quality Inn Cairo I-57 13201 Kessler Rd., Cairo, IL 62914
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  • 3-star Highway property
  • 2 floors in property
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From£45
Poor 2.0 /5 Recent Reviews Call BookMore Details
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Super 8 by Wyndham Charleston/Sikeston East MO 310 South Story, Charleston, MO 63834
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~10.13 miles southwest of Cairo
  • Inexpensive Highway property
  • 60 rooms in property
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From£31
Average 3.5 /5 Guest Reviews Call BookMore Details
The Riverstone Hotel Charleston-Sikeston 102 Drake St., Charleston, MO 63834
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~11.88 miles southwest of Cairo
  • Economical Highway property
  • Hotel has 9 suites
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From£44
Average 3.0 /5 Guest Reviews Call BookMore Details
Americas Best Value Inn Ullin Mounds 128 Cheekwood Lane, Ullin, IL 62992
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~17.88 miles north of Cairo
  • 2 star hotel
  • Check in: 15:00
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From£45
Average 3.0 /5 Recent Reviews Call BookMore Details
Motel 6 Sikeston Mo - SIKESTON 110 South Interstate Dr., SIKESTON, MO 63801
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~20.96 miles west of Cairo
  • Inexpensive property
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From£45
Average 3.0 /5 Reviews Call BookMore Details
Best Western Plus Sikeston I-55 : 120 South Interstate Dr. 120 South Interstate Dr., Sikeston, MO 63801
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~21.00 miles west of Cairo
  • Low priced Highway property
  • 2 floors in property
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From£32
Very good 4.0 /5 Read Reviews Call BookMore Details
Days Inn & Suites by Wyndham Sikeston - Sikeston 220 South Interstate Dr., Sikeston, MO 63801
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~21.07 miles west of Cairo
  • Cheap hotel
  • Check in time: 03:00 PM
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From£45
Average 3.0 /5 Review Score Call BookMore Details
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) : 100 Matthews Lane 100 Matthews Lane, Sikeston, MO 63801
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~21.31 miles west of Cairo
  • 3-star Highway property
  • Free breakfast
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From£60
Very good 4.0 /5 Guest Reviews Call BookMore Details
Super 8 by Wyndham Sikeston/Miner Area in Sikeston 2609 East Malone, Sikeston, MO 63801
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~21.32 miles west of Cairo
  • Inexpensive Convention Center property
  • Complimentary breakfast is offered
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From£45
Average 3.0 /5 Guest Reviews Call BookMore Details
Comfort Inn in Sikeston 109 Matthews Lane, Sikeston, MO 63801
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~21.34 miles west of Cairo
  • Midscale Highway hotel
  • Check-in time: 11:00
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From£64
Average 3.0 /5 Read Reviews Call BookMore Details
Drury Inn & Suites Sikeston in Sikeston 2608 East Malone Ave., Sikeston, MO 63801
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~21.37 miles west of Cairo
  • Midscale Highway property
  • 14 suites in property
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From£78
Very good 4.5 /5 Guest Reviews Call BookMore Details
Pear Tree Inn Sikeston 2602 East Malone, Sikeston, MO 63801
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~21.38 miles west of Cairo
  • 3 star Suburban hotel
  • 2 suites in property
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From£60
Average 3.0 /5 Reviews Call BookMore Details
Hampton Inn Sikeston 1240 Commerce Dr., Sikeston, MO 63801
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~24.48 miles west of Cairo
  • Midscale Rural hotel
  • Hotel has 92 rooms
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From£60
Average 3.0 /5 Read Reviews Call BookMore Details
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Holiday Inn Express & Suites Sikeston An Ihg Hotel 115 Hospitality Dr., Sikeston, MO 63801
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~24.49 miles west of Cairo
  • Mid-scale Rural property
  • 3 floors in property
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From£60
Average 3.0 /5 Hotel Reviews Call BookMore Details
Residence Inn by Marriott Paducah 3900 Coleman Crossing Circle, Paducah, KY 42001
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~25.66 miles east of Cairo
  • Midscale Suburban hotel
  • 3 floors in property
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From£67
Very good 4.0 /5 Recent Reviews Call BookMore Details
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Pear Tree Inn Paducah - Paducah 5006 Hinkleville Rd., Paducah, KY 42001
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~25.77 miles east of Cairo
  • Low-priced Suburban hotel
  • 2 floors in property
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From£41
Very good 4.0 /5 Reviews Call BookMore Details
Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destinatio : 100 East Front St. 100 East Front St., Metropolis, IL 62960
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~26.28 miles east of Cairo
  • High-end hotel
  • 12 suites in property
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From£121
Very good 4.0 /5 Recent Reviews Call BookMore Details
Baymont by Wyndham Metropolis : 203 East Front St. 203 East Front St., Metropolis, IL 62960
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~26.32 miles east of Cairo
  • Two-star Riverfront hotel
  • Check-in: 3:00PM
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From£34
Average 3.0 /5 Recent Reviews Call BookMore Details
Econo Lodge 1415 East 5th St., Metropolis, IL 62960
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~27.38 miles east of Cairo
  • 2-star property
  • Check in time: 11:00
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From£45
Terrible 1.0 /5 Reviews Call BookMore Details
 Econo Lodge Paducah West I-24 : 5120 Hinkleville Rd. 5120 Hinkleville Rd., Paducah, KY 42001
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~27.55 miles east of Cairo
  • 2 star Airport property
  • Hotel has 2 floors
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From£45
Average 3.0 /5 Review Score Call BookMore Details
Baymont by Wyndham Paducah : 5300 Old Cairo Rd. 5300 Old Cairo Rd., Paducah, KY 42001
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~27.64 miles east of Cairo
  • Midscale hotel
  • 74 rooms in hotel
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From£30
Poor 2.0 /5 Review Score Call BookMore Details
Courtyard by Marriott Cape Girardeau Downtown 400 Broadway St., Cape Girardeau, MO 63701
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~27.65 miles northwest of Cairo
  • 3 star Downtown hotel
  • 78 rooms in hotel
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From£60
Very good 4.0 /5 Guest Reviews Call BookMore Details
Drury Suites Paducah 2930 James Sanders Blvd., Paducah, KY 42001
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~27.70 miles east of Cairo
  • Mid-scale Suburban property
  • 6 floors in hotel
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From£74
Very good 4.0 /5 Review Score Call BookMore Details
Quality Suites Paducah I-24 : 2880 James Sanders Blvd. 2880 James Sanders Blvd., Paducah, KY 42001 Website
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~27.73 miles east of Cairo
  • 2 star Highway hotel
  • 59 suites in property
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From£45
Average 3.0 /5 Latest Reviews Call BookMore Details
Comfort Inn & Suites near Six Flags - Lithia Springs 960 West Pointe Court, Lithia Springs, GA 30122 Website
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~27.80 miles east of Cairo
  • Affordable Downtown hotel
  • Hotel has 2 floors
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From£53
Very good 4.0 /5 Recent Reviews Call BookMore Details
Garner Hotel Paducah West by IHG : 145 Mcbride Lane 145 Mcbride Lane, Paducah, KY 42001
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~27.80 miles east of Cairo
  • Affordable Highway property
  • Check-in time: 3pm
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From£37
Very good 4.0 /5 Latest Reviews Call BookMore Details
Hotel 7 Inn Paducah : 5001 Hinkleville Rd. 5001 Hinkleville Rd., Paducah, KY 42001
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~27.81 miles east of Cairo
  • Low Cost property
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From£45
Average 3.0 /5 Hotel Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham Paducah 3960 Coleman Crossing Cir, Paducah, KY 42001
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~27.90 miles east of Cairo
  • Affordable Highway property
  • Has environment-friendly policy Read more
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From£60
Average 3.0 /5 Review Score Call BookMore Details
Candlewood Suites Paducah by IHG - Paducah 3940 Coleman Crossing Circle, Paducah, KY 42001
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~27.91 miles east of Cairo
  • Affordable Rural property
  • Fitness / Gym is on-site
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From£45
Very good 4.0 /5 Recent Reviews Call BookMore Details
Homewood Suites by Hilton Paducah 3925 Coleman Crossing Cir, Paducah, KY 42001
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~27.94 miles east of Cairo
  • Midscale Highway hotel
  • Comp. Breakfast
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From£82
Very good 4.0 /5 Review Score Call BookMore Details
Comfort Suites 3918 Coleman Crossing Cir Paducah Ky 42001, Paducah, KY 42001
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~27.96 miles east of Cairo
  • Inexpensive Rural hotel
  • Free complimentary breakfast
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From£45
Average 3.0 /5 Latest Reviews Call BookMore Details
Comfort Inn Paducah 5135 Cairo Rd., Paducah, KY 42001
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~27.98 miles east of Cairo
  • 3 star hotel
  • 3 floors in property
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From£44
Very good 4.0 /5 Guest Reviews Call BookMore Details
Fairfield Inn & Suites by Marriott Paducah 3950 Coleman Crossing Circle, Paducah, KY 42001
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~28.01 miles east of Cairo
  • Affordable Rural property
  • Comp. Breakfast
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From£56
Very good 4.0 /5 Guest Reviews Call BookMore Details
Red Roof Inn Paducah 5106 Old Cairo Rd., Paducah, KY 42001
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~28.01 miles east of Cairo
  • Low Cost property
  • Hotel has 8 suites
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From£34
Average 3.5 /5 Review Score Call BookMore Details
American Inn 5125 Cairo Rd., Paducah, KY 42001
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~28.02 miles east of Cairo
  • Two star hotel
  • 2 floors in hotel
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From£28
Very good 4.0 /5 Recent Reviews Call BookMore Details
Hampton Inn & Suites Paducah - Paducah 3901 Coleman Crossing Circle, Paducah, KY 42001
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~28.02 miles east of Cairo
  • 3 star Highway hotel
  • Free breakfast available
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From£59
Very good 4.5 /5 Review Score Call BookMore Details
Holiday Inn Express Hotel & Suites Paducah West by IHG 3996 Hinkleville Rd., Paducah, KY 42001
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~28.04 miles east of Cairo
  • 3-star Highway hotel
  • Check in: 3:00 PM
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From£60
Average 3.0 /5 Latest Reviews Call BookMore Details
Auburn Place Hotel & Suites - Paducah - Paducah 3994 Hinkleville Rd., Paducah, KY 42001
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~28.05 miles east of Cairo
  • Midscale Airport property
  • Gym is available on property
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From£60
Very good 4.0 /5 Review Score Call BookMore Details
Courtyard by Marriott Paducah in Paducah 3835 Technology Dr., Paducah, KY 42001
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~28.29 miles east of Cairo
  • 3-star Suburban property
  • 3 suites in property
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From£67
Very good 4.0 /5 Review Score Call BookMore Details
Drury Inn Paducah 3975 Hinkleville Rd., Paducah, KY 42001
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~28.70 miles east of Cairo
  • 3-star Suburban property
  • Free comp. breakfast
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From£59
Very good 4.5 /5 Guest Reviews Call BookMore Details
Days Inn by Wyndham Paducah I-24 Exit 4 in Paducah 3901 Hinkleville Rd., Paducah, KY 42001
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~28.75 miles east of Cairo
  • Two-star Highway hotel
  • Check in: 11:00 am
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From£37
Average 3.0 /5 Latest Reviews Call BookMore Details
Candlewood Suites Cape Girardeau by IHG 485 South Mount Auburn Rd., Cape Girardeau, MO 65703
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~28.76 miles northwest of Cairo
  • Cheap Highway property
  • 85 rooms in property
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From£52
Very good 4.0 /5 Recent Reviews Call BookMore Details
Travelers Inn and Suites 2550 Lone Oak Rd., Paducah, KY 42003
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~28.88 miles east of Cairo
  • Two star hotel
  • Check in time: 2:00PM
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From£28
Very good 4.0 /5 Latest Reviews Call BookMore Details
Quality Inn & Suites Metropolis I-24 2118 East 5th St., Metropolis, IL 62960
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~28.88 miles east of Cairo
  • 3 star property
  • Check in: 11:00
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From£60
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Super 8 by Wyndham Metropolis in Metropolis 2055 East 5th St., Metropolis, IL 62960
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~28.89 miles east of Cairo
  • 2-star Highway hotel
  • Free breakfast available
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From£45
Average 3.0 /5 Hotel Reviews Call BookMore Details
Motel 6 Metropolis Il in Metropolis 2119 East 5th St., Metropolis, IL 62960
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~29.04 miles east of Cairo
  • Two-star property
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From£45
Average 3.0 /5 Recent Reviews Call BookMore Details
Holiday Inn Express Metropolis by IHG : 2179 East 5th St. 2179 East 5th St., Metropolis, IL 62960
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~29.10 miles east of Cairo
  • 3 star Rural hotel
  • 21 suites in property
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From£49
Very good 4.0 /5 Review Score Call BookMore Details
Hampton Inn Cape Girardeau I 55 East : 207 South Mount Auburn Rd. 207 South Mount Auburn Rd., Cape Girardeau, MO 63703
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~29.41 miles northwest of Cairo
  • 3-star Highway property
  • Check in: 3:00 pm
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From£60
Excellent 5.0 /5 Review Score Call BookMore Details
Victorian Inn & Suites in Cape Girardeau 3256 William St., Cape Girardeau, MO 63703
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~29.41 miles northwest of Cairo
  • 3-star Golf Course property
  • Hotel has 2 floors
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From£59
Average 3.0 /5 Latest Reviews Call BookMore Details
Auburn Place Hotel & Suites - Cape Girardeau 3265 Williams St., Cape Girardeau, MO 63702
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~29.42 miles northwest of Cairo
  • Midscale Highway hotel
  • Free comp. breakfast
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From£43
Very good 4.5 /5 Hotel Reviews Call BookMore Details

Next: See My Cairo Hotels with Pricing

Graph: Upcoming 20 Days of Cairo Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Cairo, IL discounts available. The chart reflects the cheapest Cairo hotel for each day and each star rating category.

FAQs about hotels in Cairo

What are the most favored hotels in Cairo?

Hampton Inn Cape Girardeau I 55 East, Drury Inn & Suites Sikeston and Hampton Inn & Suites Paducah are the best rated hotels based on customer reviews in the last 365 days.

What are the most luxurious hotels in Cairo?

Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destinatio, Quality Inn Cairo I-57 and Travel Inn & Suites - Sikeston are the top 3 luxury hotels near Cairo city center.

What hotels are closest to the city center of Cairo?

Quality Inn Cairo I-57, Super 8 by Wyndham Charleston, and The Riverstone Hotel Charleston-Sikeston are the properties closest to Cairo city center.

What are the best independent hotels in Cairo?

Auburn Place Hotel & Suites, Travel Inn & Suites - Sikeston and Drury Suites Paducah are the best rated independent hotels (not part of a big brand).

What are the most popular Marriott hotels in Cairo?

Residence Inn by Marriott Paducah, Courtyard by Marriott Cape Girardeau Downtown and Fairfield Inn & Suites by Marriott Paducah are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the best Choice Hotels branded hotels in Cairo?

Comfort Inn & Suites near Six Flags, Comfort Inn Paducah and Quality Inn & Suites Metropolis I-24 are the best rated Choice Hotels branded hotels (based on HotelPlanner reviews score).

What are the most popular IHG hotels in Cairo?

Candlewood Suites Paducah by IHG, Candlewood Suites Cape Girardeau by IHG and Holiday Inn Express Metropolis by IHG are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

Verified reviews of the city: Cairo, IL

Below are reviews of the city of Cairo, IL from an actual visitor's perspective.

"Spending time with my family"
Score 5.0 / 5

Vincent R., from 26-Jan-2026
The average traveler rating of the city of Cairo, IL shown above is 5.0 out of 5 based on 1 reviews
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