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Cairo Illinois Accommodations

Find hotels & motels in Cairo using the list below. Search for cheap and discounted hotel and motel rates in or close to Cairo, IL for your upcoming individual or group travel. Discover the best Cairo Illinois hotel/motel rooms. Review the Cairo hotel list below to find the perfect lodging. We also have a map of the Cairo hotels.

Cairo Hotels/Motels & Accommodations

Quality Inn Cairo I-57 : 13201 Kessler Rd.
+1-888-389-4121
13201 Kessler Rd., Cairo, IL 62914
  • 3 star Highway hotel
  • 38 rooms in hotel
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Super 8 by Wyndham Charleston/Sikeston East MO
+1-888-675-2083
310 South Story, Charleston, MO 63834 ~10.13 miles southwest of Cairo
  • Low Cost Highway hotel
  • Hotel has 7 suites
From£31
Average 3.5 /5 Review Score Call BookMore Details
Quality Inn Charleston - Sikeston in Charleston
+1-800-716-8490
102 Drake St., Charleston, MO 63834 ~11.88 miles southwest of Cairo
  • Cheap Highway property
  • 9 suites in hotel
From£44
Average 3.0 /5 Guest Reviews Call BookMore Details
Americas Best Value Inn Ullin Mounds - Ullin
+1-800-805-5223
128 Cheekwood Lane, Ullin, IL 62992 ~17.88 miles north of Cairo
  • Inexpensive property
  • Hotel has 40 rooms
From£44
Average 3.0 /5 Hotel Reviews Call BookMore Details
Motel 6 Sikeston Mo
+1-888-965-1860
110 South Interstate Dr., SIKESTON, MO 63801 ~20.96 miles west of Cairo
  • Low Cost hotel
From£44
Average 3.0 /5 Review Score Call BookMore Details
Best Western Plus Sikeston
+1-888-788-5576
120 South Interstate Dr., Sikeston, MO 63801 ~21.00 miles west of Cairo
  • Two star Highway hotel
  • Hotel has an eco-friendly policy See more
From£32
Very good 4.0 /5 Latest Reviews Call BookMore Details
Days Inn and Suites by Wyndham Sikeston : 220 South Interstate Dr.
+1-888-897-9207
220 South Interstate Dr., Sikeston, MO 63801 ~21.07 miles west of Cairo
  • Economical property
  • Check in: 03:00 PM
From£44
Average 3.0 /5 Latest Reviews Call BookMore Details
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) : 100 Matthews Lane
+1-888-311-4278
100 Matthews Lane, Sikeston, MO 63801 ~21.31 miles west of Cairo
  • 3-star Highway property
  • Check-in time: 3:00 PM
From£59
Very good 4.0 /5 Reviews Call BookMore Details
Super 8 by Wyndham Sikeston/Miner Area
+1-888-469-4795
2609 East Malone, Sikeston, MO 63801 ~21.32 miles west of Cairo
  • Economical Convention Center hotel
  • Free breakfast available
From£44
Average 3.0 /5 Reviews Call BookMore Details
Comfort Inn
+1-888-734-9421
109 Matthews Lane, Sikeston, MO 63801 ~21.34 miles west of Cairo
  • Affordable Highway property
  • Hotel has 64 rooms
From£63
Average 3.0 /5 Hotel Reviews Call BookMore Details
Pear Tree Inn Sikeston : 2602 East Malone
+1-888-841-5292
2602 East Malone, Sikeston, MO 63801 ~21.38 miles west of Cairo
  • Midscale Suburban hotel
  • Hotel has an eco-friendly policy See policy
From£59
Average 3.0 /5 Latest Reviews Call BookMore Details
Hampton Inn Sikeston
+1-888-455-5160
1240 Commerce Dr., Sikeston, MO 63801 ~24.48 miles west of Cairo
  • Three Star Rural property
  • Hotel has 4 floors
From£59
Average 3.0 /5 Read Reviews Call BookMore Details
Holiday Inn Express & Suites Sikeston An Ihg Hotel - Sikeston
+1-888-965-8297
115 Hospitality Dr., Sikeston, MO 63801 ~24.49 miles west of Cairo
  • Mid-scale Rural hotel
  • 73 sleeping rooms in hotel
From£59
Average 3.0 /5 Guest Reviews Call BookMore Details
Residence Inn by Marriott Paducah
+1-888-906-6358
3900 Coleman Crossing Circle, Paducah, KY 42001 ~25.66 miles east of Cairo
  • 3-star Suburban hotel
  • Check in: 3:00PM
From£66
Very good 4.0 /5 Read Reviews Call BookMore Details
Pear Tree Inn Paducah in Paducah
+1-888-749-6785
5006 Hinkleville Rd., Paducah, KY 42001 ~25.77 miles east of Cairo
  • Cheap Suburban hotel
  • Fitness / Gym is on-site
From£41
Very good 4.0 /5 Recent Reviews Call BookMore Details
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Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destinatio - Metropolis
+1-888-878-9982
100 East Front St., Metropolis, IL 62960 ~26.28 miles east of Cairo
  • High end hotel
  • Hotel has 252 rooms
From£119
Very good 4.0 /5 Latest Reviews Call BookMore Details
Baymont by Wyndham Metropolis in Metropolis
+1-888-389-4485
203 East Front St., Metropolis, IL 62960 ~26.32 miles east of Cairo
  • 2-star Riverfront property
  • Gym is available on property
From£33
Average 3.0 /5 Guest Reviews Call BookMore Details
Econo Lodge in Metropolis
+1-888-389-4121
1415 East 5th St., Metropolis, IL 62960 ~27.38 miles east of Cairo
  • Cheap property
  • Check in: 11:00
From£44
Terrible 1.0 /5 Guest Reviews Call BookMore Details
 Econo Lodge Paducah West I-24
+1-888-675-2083
5120 Hinkleville Rd., Paducah, KY 42001 ~27.55 miles east of Cairo
  • Two-star Airport hotel
  • Hotel has 75 rooms
From£44
Average 3.0 /5 Reviews Call BookMore Details
Baymont by Wyndham Paducah : 5300 Old Cairo Rd.
+1-800-716-8490
5300 Old Cairo Rd., Paducah, KY 42001 ~27.64 miles east of Cairo
  • 3-star property
  • Check-in: 15:00
From£29
Poor 2.0 /5 Review Score Call BookMore Details
Courtyard by Marriott Cape Girardeau Downtown in Cape Girardeau
+1-800-805-5223
400 Broadway St., Cape Girardeau, MO 63701 ~27.65 miles northwest of Cairo
  • Midscale Downtown hotel
  • Check in: 3:00 pm
From£59
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Drury Suites Paducah
+1-888-965-1860
2930 James Sanders Blvd., Paducah, KY 42001 ~27.70 miles east of Cairo
  • 3 star Suburban hotel
  • 6 floors in property
From£74
Very good 4.0 /5 Recent Reviews Call BookMore Details
Quality Suites Paducah I-24
+1-888-788-5576
2880 James Sanders Blvd., Paducah, KY 42001 Website ~27.73 miles east of Cairo
  • Cheap Highway property
  • Has environment-friendly policy Learn more
From£44
Average 3.0 /5 Latest Reviews Call BookMore Details
Garner Hotel Paducah West by IHG
+1-888-897-9207
145 Mcbride Lane, Paducah, KY 42001 ~27.80 miles east of Cairo
  • Midscale Highway hotel
  • Hotel has 60 rooms
From£36
Very good 4.0 /5 Review Score Call BookMore Details
Comfort Inn & Suites near Six Flags
+1-888-311-4278
960 West Pointe Court, Lithia Springs, GA 30122 Website ~27.80 miles east of Cairo
  • Midscale Downtown hotel
  • Free complimentary breakfast
From£52
Very good 4.0 /5 Recent Reviews Call BookMore Details
Hotel 7 Inn Paducah - Paducah
+1-888-469-4795
5001 Hinkleville Rd., Paducah, KY 42001 ~27.81 miles east of Cairo
  • Low priced hotel
From£44
Average 3.0 /5 Recent Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham Paducah - Paducah
+1-888-734-9421
3960 Coleman Crossing Cir, Paducah, KY 42001 ~27.90 miles east of Cairo
  • 3 star Highway hotel
  • Check in time: 3;00PM
From£59
Average 3.0 /5 Reviews Call BookMore Details
Candlewood Suites Paducah by IHG
+1-888-841-5292
3940 Coleman Crossing Circle, Paducah, KY 42001 ~27.91 miles east of Cairo
  • Three Star Rural hotel
  • Check-in: 3:00pm
From£44
Very good 4.0 /5 Guest Reviews Call BookMore Details
Homewood Suites by Hilton Paducah in Paducah
+1-888-455-5160
3925 Coleman Crossing Cir, Paducah, KY 42001 ~27.94 miles east of Cairo
  • Midscale Highway property
  • 97 sleeping rooms in hotel
From£81
Very good 4.0 /5 Read Reviews Call BookMore Details
Comfort Suites : 3918 Coleman Crossing Cir Paducah Ky 42001
+1-888-965-8297
3918 Coleman Crossing Cir Paducah Ky 42001, Paducah, KY 42001 ~27.96 miles east of Cairo
  • Cheap Rural hotel
  • 4 floors in hotel
From£44
Average 3.0 /5 Guest Reviews Call BookMore Details
Comfort Inn Paducah in Paducah
+1-888-906-6358
5135 Cairo Rd., Paducah, KY 42001 ~27.98 miles east of Cairo
  • 3-star property
  • Check-in: 3:00 PM
From£44
Very good 4.0 /5 Reviews Call BookMore Details
Fairfield Inn & Suites by Marriott Paducah : 3950 Coleman Crossing Circle
+1-888-749-6785
3950 Coleman Crossing Circle, Paducah, KY 42001 ~28.01 miles east of Cairo
  • Mid-scale Rural property
  • Fitness / Gym is on-site
From£56
Very good 4.0 /5 Read Reviews Call BookMore Details
Red Roof Inn Paducah
+1-888-878-9982
5106 Old Cairo Rd., Paducah, KY 42001 ~28.01 miles east of Cairo
  • 2-star hotel
  • Check in: 14:00
From£33
Average 3.5 /5 Review Score Call BookMore Details
American Inn - Paducah
+1-888-389-4485
5125 Cairo Rd., Paducah, KY 42001 ~28.02 miles east of Cairo
  • Cheap property
  • Check-in time: 14:00
From£27
Very good 4.0 /5 Reviews Call BookMore Details
Holiday Inn Express Hotel & Suites Paducah West by IHG
+1-888-389-4121
3996 Hinkleville Rd., Paducah, KY 42001 ~28.04 miles east of Cairo
  • 3-star Highway hotel
  • 16 suites in property
From£59
Average 3.0 /5 Recent Reviews Call BookMore Details
Auburn Place Hotel & Suites - Paducah : 3994 Hinkleville Rd.
+1-888-675-2083
3994 Hinkleville Rd., Paducah, KY 42001 ~28.05 miles east of Cairo
  • 3-star Airport hotel
  • Check in time: 3:00 PM
From£59
Very good 4.0 /5 Reviews Call BookMore Details
Courtyard by Marriott Paducah
+1-800-716-8490
3835 Technology Dr., Paducah, KY 42001 ~28.29 miles east of Cairo
  • 3-star Suburban hotel
  • Hotel has 100 rooms
From£66
Very good 4.0 /5 Latest Reviews Call BookMore Details
Days Inn by Wyndham Paducah I-24 Exit 4 in Paducah
+1-800-805-5223
3901 Hinkleville Rd., Paducah, KY 42001 ~28.75 miles east of Cairo
  • Cheap Highway hotel
  • 32 suites in hotel
From£37
Average 3.0 /5 Recent Reviews Call BookMore Details
Candlewood Suites Cape Girardeau by IHG - Cape Girardeau
+1-888-965-1860
485 South Mount Auburn Rd., Cape Girardeau, MO 65703 ~28.76 miles northwest of Cairo
  • Low priced Highway hotel
  • Hotel has 85 suites
From£51
Very good 4.0 /5 Review Score Call BookMore Details
Travelers Inn and Suites
+1-888-788-5576
2550 Lone Oak Rd., Paducah, KY 42003 ~28.88 miles east of Cairo
  • 2-star hotel
  • 2 floors in hotel
From£28
Very good 4.0 /5 Guest Reviews Call BookMore Details
Quality Inn & Suites Metropolis I-24
+1-888-897-9207
2118 East 5th St., Metropolis, IL 62960 ~28.88 miles east of Cairo
  • 3-star hotel
  • 52 rooms in property
From£59
Very good 4.0 /5 Reviews Call BookMore Details
Super 8 by Wyndham Metropolis
+1-888-311-4278
2055 East 5th St., Metropolis, IL 62960 ~28.89 miles east of Cairo
  • Low priced Highway hotel
  • Free breakfast
From£44
Average 3.0 /5 Hotel Reviews Call BookMore Details
Motel 6 Metropolis Il : 2119 East 5th St.
+1-888-469-4795
2119 East 5th St., Metropolis, IL 62960 ~29.04 miles east of Cairo
  • Economical hotel
From£44
Average 3.0 /5 Review Score Call BookMore Details
Holiday Inn Express Metropolis by IHG
+1-888-734-9421
2179 East 5th St., Metropolis, IL 62960 ~29.10 miles east of Cairo
  • Affordable Rural property
  • Complimentary breakfast is offered
From£48
Very good 4.0 /5 Recent Reviews Call BookMore Details
Hampton Inn Cape Girardeau I 55 East - Cape Girardeau
+1-888-841-5292
207 South Mount Auburn Rd., Cape Girardeau, MO 63703 ~29.41 miles northwest of Cairo
  • 3-star Highway property
  • 86 sleeping rooms in hotel
From£59
Excellent 5.0 /5 Read Reviews Call BookMore Details
Victorian Inn & Suites - Cape Girardeau
+1-888-455-5160
3256 William St., Cape Girardeau, MO 63703 ~29.41 miles northwest of Cairo
  • Midscale Golf Course property
  • 5 suites in property
From£59
Average 3.0 /5 Hotel Reviews Call BookMore Details
Auburn Place Hotel & Suites : 3265 Williams St.
+1-888-965-8297
3265 Williams St., Cape Girardeau, MO 63702 ~29.42 miles northwest of Cairo
  • Three Star Highway property
  • 133 rooms in hotel
From£43
Very good 4.5 /5 Recent Reviews Call BookMore Details
Holiday Inn Express & Suites Cape Girardeau I 55 by Ihg - Cape Girardeau
+1-888-906-6358
3253 William St., Cape Girardeau, MO 63701 ~29.49 miles northwest of Cairo
  • Affordable hotel
  • Hotel has 102 suites
From£59
Very good 4.5 /5 Reviews Call BookMore Details
Pear Tree Inn Cape Girardeau Medical Center
+1-888-749-6785
3248 William St., Cape Girardeau, MO 63701 ~29.53 miles northwest of Cairo
  • Inexpensive Highway property
  • Hotel has 3 floors
From£49
Very good 4.0 /5 Guest Reviews Call BookMore Details
Fairfield Inn & Suites Cape Girardeau - Cape Girardeay
+1-888-878-9982
433 Cape West Crossing, Cape Girardeay, MO 63703 ~29.58 miles northwest of Cairo
  • Midscale property
  • 22 suites in hotel
From£59
Average 3.0 /5 Hotel Reviews Call BookMore Details

Next: See My Cairo Hotels with Pricing

Graph: Upcoming 20 Days of Cairo Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Cairo, IL discounts available. The chart reflects the cheapest Cairo hotel for each day and each star rating category.

FAQs about hotels in Cairo

What are the most favored hotels in Cairo?

Hampton Inn Cape Girardeau I 55 East, Auburn Place Hotel & Suites and Holiday Inn Express & Suites Cape Girardeau I 55 by Ihg are the best rated hotels based on customer reviews in the last 365 days.

What are the most luxurious hotels in Cairo?

Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destinatio, Quality Inn Cairo I-57 and Travel Inn & Suites - Sikeston are the top 3 luxury hotels near Cairo city center.

What hotels are closest to the city center of Cairo?

Quality Inn Cairo I-57, Super 8 by Wyndham Charleston, and Quality Inn Charleston - Sikeston are the properties closest to Cairo city center.

What are the best independent hotels in Cairo?

Auburn Place Hotel & Suites, Travel Inn & Suites - Sikeston and Drury Suites Paducah are the best rated independent hotels (not part of a big brand).

What are the most popular Marriott hotels in Cairo?

Residence Inn by Marriott Paducah, Courtyard by Marriott Cape Girardeau Downtown and Fairfield Inn & Suites by Marriott Paducah are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the best Choice Hotels branded hotels in Cairo?

Comfort Inn & Suites near Six Flags, Comfort Inn Paducah and Quality Inn & Suites Metropolis I-24 are the best rated Choice Hotels branded hotels (based on HotelPlanner reviews score).

What are the best IHG hotels in Cairo?

Holiday Inn Express & Suites Cape Girardeau I 55 by Ihg, Candlewood Suites Paducah by IHG and Candlewood Suites Cape Girardeau by IHG are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

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