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Cairo Illinois Accommodations

Find hotels & motels in Cairo using the list below. Search for cheap and discounted hotel and motel rates in or close to Cairo, IL for your upcoming individual or group travel. Discover the best Cairo Illinois hotel/motel rooms. Review the Cairo hotel list below to find the perfect lodging. We also have a map of the Cairo hotels.

Cairo Hotels & Accommodations

Quality Inn Cairo I-57 in Cairo 13201 Kessler Rd., Cairo, IL 62914
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  • 3-star Highway property
  • Check-in time: 3 pm
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From£44
Poor 2.0 /5 Review Score Call BookMore Details
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Super 8 by Wyndham Charleston/Sikeston East MO 310 South Story, Charleston, MO 63834
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~10.13 miles southwest of Cairo
  • Two star Highway hotel
  • 60 rooms in property
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From£30
Average 3.5 /5 Read Reviews Call BookMore Details
Quality Inn Charleston - Sikeston : 102 Drake St. 102 Drake St., Charleston, MO 63834
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~11.88 miles southwest of Cairo
  • Cheap Highway hotel
  • Check-in time: 3:00PM
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From£43
Average 3.0 /5 Guest Reviews Call BookMore Details
Americas Best Value Inn Ullin Mounds in Ullin 128 Cheekwood Lane, Ullin, IL 62992
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~17.88 miles north of Cairo
  • Economical property
  • Comp. Breakfast
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From£44
Average 3.0 /5 Latest Reviews Call BookMore Details
Motel 6 Sikeston Mo 110 South Interstate Dr., SIKESTON, MO 63801
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~20.96 miles west of Cairo
  • 2-star hotel
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From£44
Average 3.0 /5 Review Score Call BookMore Details
Best Western Plus Sikeston 120 South Interstate Dr., Sikeston, MO 63801
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~21.00 miles west of Cairo
  • Two-star Highway hotel
  • Hotel has an eco-friendly policy See policy
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From£31
Very good 4.0 /5 Reviews Call BookMore Details
Days Inn and Suites by Wyndham Sikeston in Sikeston 220 South Interstate Dr., Sikeston, MO 63801
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~21.07 miles west of Cairo
  • Cheap property
  • Gym / Fitness Center Available
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From£44
Average 3.0 /5 Guest Reviews Call BookMore Details
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) 100 Matthews Lane, Sikeston, MO 63801
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~21.31 miles west of Cairo
  • Mid-scale Highway property
  • Comp. Breakfast
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From£58
Very good 4.0 /5 Read Reviews Call BookMore Details
Super 8 by Wyndham Sikeston/Miner Area 2609 East Malone, Sikeston, MO 63801
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~21.32 miles west of Cairo
  • Inexpensive Convention Center hotel
  • Check-in time: 01:00
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From£44
Average 3.0 /5 Reviews Call BookMore Details
Comfort Inn : 109 Matthews Lane 109 Matthews Lane, Sikeston, MO 63801
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~21.34 miles west of Cairo
  • Three Star Highway property
  • Check-in: 11:00
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From£62
Average 3.0 /5 Recent Reviews Call BookMore Details
Hampton Inn Sikeston 1240 Commerce Dr., Sikeston, MO 63801
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~24.48 miles west of Cairo
  • Mid-scale Rural property
  • Check in: 3:00 PM
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From£58
Average 3.0 /5 Reviews Call BookMore Details
Holiday Inn Express & Suites Sikeston An Ihg Hotel 115 Hospitality Dr., Sikeston, MO 63801
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~24.49 miles west of Cairo
  • Affordable Rural property
  • 73 sleeping rooms in hotel
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From£58
Average 3.0 /5 Read Reviews Call BookMore Details
Residence Inn by Marriott Paducah in Paducah 3900 Coleman Crossing Circle, Paducah, KY 42001
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~25.66 miles east of Cairo
  • Affordable Suburban hotel
  • Check-in: 3:00PM
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From£65
Very good 4.0 /5 Reviews Call BookMore Details
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Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destinatio 100 East Front St., Metropolis, IL 62960
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~26.28 miles east of Cairo
  • High-end hotel
  • Hotel has 12 suites
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From£117
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Baymont by Wyndham Metropolis 203 East Front St., Metropolis, IL 62960
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~26.32 miles east of Cairo
  • Economical Riverfront property
  • 2 floors in property
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From£33
Average 3.0 /5 Hotel Reviews Call BookMore Details
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Econo Lodge : 1415 East 5th St. 1415 East 5th St., Metropolis, IL 62960
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~27.38 miles east of Cairo
  • Cheap property
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From£44
Terrible 1.0 /5 Recent Reviews Call BookMore Details
 Econo Lodge Paducah West I-24 - Paducah 5120 Hinkleville Rd., Paducah, KY 42001
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~27.55 miles east of Cairo
  • Inexpensive Airport property
  • Check-in time: 15:00pm
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From£44
Average 3.0 /5 Reviews Call BookMore Details
Baymont by Wyndham Paducah : 5300 Old Cairo Rd. 5300 Old Cairo Rd., Paducah, KY 42001
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~27.64 miles east of Cairo
  • 3 star property
  • Hotel has 4 suites
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From£29
Poor 2.0 /5 Recent Reviews Call BookMore Details
Courtyard by Marriott Cape Girardeau Downtown 400 Broadway St., Cape Girardeau, MO 63701
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~27.65 miles northwest of Cairo
  • Mid-scale Downtown hotel
  • 13 suites in hotel
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From£58
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Drury Suites Paducah 2930 James Sanders Blvd., Paducah, KY 42001
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~27.70 miles east of Cairo
  • 3-star Suburban hotel
  • Hotel has a green policy See policy
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From£72
Very good 4.0 /5 Recent Reviews Call BookMore Details
Quality Suites Paducah I-24 - Paducah 2880 James Sanders Blvd., Paducah, KY 42001 Website
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~27.73 miles east of Cairo
  • Low-priced Highway hotel
  • Hotel has 59 suites
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From£44
Average 3.0 /5 Reviews Call BookMore Details
Comfort Inn & Suites near Six Flags - Lithia Springs 960 West Pointe Court, Lithia Springs, GA 30122 Website
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~27.80 miles east of Cairo
  • 3 star Downtown hotel
  • Free complimentary breakfast
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From£51
Very good 4.0 /5 Guest Reviews Call BookMore Details
Garner Hotel Paducah West by IHG - Paducah 145 Mcbride Lane, Paducah, KY 42001
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~27.80 miles east of Cairo
  • Mid-scale Highway hotel
  • Free breakfast available
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From£35
Very good 4.0 /5 Recent Reviews Call BookMore Details
Hotel 7 Inn Paducah : 5001 Hinkleville Rd. 5001 Hinkleville Rd., Paducah, KY 42001
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~27.81 miles east of Cairo
  • Two-star hotel
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From£44
Average 3.0 /5 Hotel Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham Paducah : 3960 Coleman Crossing Cir 3960 Coleman Crossing Cir, Paducah, KY 42001
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~27.90 miles east of Cairo
  • Three Star Highway property
  • Hotel has 77 rooms
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From£58
Average 3.0 /5 Recent Reviews Call BookMore Details
Candlewood Suites Paducah by IHG 3940 Coleman Crossing Circle, Paducah, KY 42001
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~27.91 miles east of Cairo
  • Mid-scale Rural hotel
  • Hotel has 4 floors
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From£44
Very good 4.0 /5 Read Reviews Call BookMore Details
Homewood Suites by Hilton Paducah 3925 Coleman Crossing Cir, Paducah, KY 42001
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~27.94 miles east of Cairo
  • 3 star Highway property
  • Hotel has 97 suites
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From£80
Very good 4.0 /5 Recent Reviews Call BookMore Details
Comfort Suites 3918 Coleman Crossing Cir Paducah Ky 42001, Paducah, KY 42001
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~27.96 miles east of Cairo
  • Cheap Rural hotel
  • 72 suites in property
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From£44
Average 3.0 /5 Review Score Call BookMore Details
Comfort Inn Paducah - Paducah 5135 Cairo Rd., Paducah, KY 42001
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~27.98 miles east of Cairo
  • Three Star property
  • 66 rooms in property
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From£43
Very good 4.0 /5 Guest Reviews Call BookMore Details
Fairfield Inn & Suites by Marriott Paducah 3950 Coleman Crossing Circle, Paducah, KY 42001
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~28.01 miles east of Cairo
  • Three Star Rural hotel
  • 2 meeting rooms in property
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From£55
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Red Roof Inn Paducah - Paducah 5106 Old Cairo Rd., Paducah, KY 42001
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~28.01 miles east of Cairo
  • 2-star hotel
  • 40 sleeping rooms in hotel
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From£33
Average 3.5 /5 Reviews Call BookMore Details
American Inn 5125 Cairo Rd., Paducah, KY 42001
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~28.02 miles east of Cairo
  • 2-star hotel
  • Check-in: 14:00
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From£27
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Hampton Inn & Suites Paducah 3901 Coleman Crossing Circle, Paducah, KY 42001
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~28.02 miles east of Cairo
  • Midscale Highway property
  • 108 rooms in property
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From£58
Very good 4.5 /5 Latest Reviews Call BookMore Details
Holiday Inn Express Hotel & Suites Paducah West by IHG 3996 Hinkleville Rd., Paducah, KY 42001
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~28.04 miles east of Cairo
  • Affordable Highway property
  • 3 floors in property
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From£58
Average 3.0 /5 Hotel Reviews Call BookMore Details
Auburn Place Hotel & Suites - Paducah - Paducah 3994 Hinkleville Rd., Paducah, KY 42001
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~28.05 miles east of Cairo
  • Affordable Airport property
  • Free comp. breakfast
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From£58
Very good 4.0 /5 Latest Reviews Call BookMore Details
Courtyard by Marriott Paducah 3835 Technology Dr., Paducah, KY 42001
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~28.29 miles east of Cairo
  • 3 star Suburban hotel
  • Access to gym on-site
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From£65
Very good 4.0 /5 Reviews Call BookMore Details
Days Inn by Wyndham Paducah I-24 Exit 4 in Paducah 3901 Hinkleville Rd., Paducah, KY 42001
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~28.75 miles east of Cairo
  • Economy Highway hotel
  • 32 suites in property
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From£36
Average 3.0 /5 Hotel Reviews Call BookMore Details
Candlewood Suites Cape Girardeau by IHG 485 South Mount Auburn Rd., Cape Girardeau, MO 65703
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~28.76 miles northwest of Cairo
  • Economy Highway hotel
  • 4 floors in property
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From£50
Very good 4.0 /5 Reviews Call BookMore Details
Travelers Inn and Suites 2550 Lone Oak Rd., Paducah, KY 42003
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~28.88 miles east of Cairo
  • Cheap property
  • 2 floors in hotel
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From£27
Very good 4.0 /5 Latest Reviews Call BookMore Details
Quality Inn & Suites Metropolis I-24 2118 East 5th St., Metropolis, IL 62960
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~28.88 miles east of Cairo
  • Three Star hotel
  • Check in time: 11:00
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From£58
Very good 4.0 /5 Latest Reviews Call BookMore Details
Super 8 by Wyndham Metropolis in Metropolis 2055 East 5th St., Metropolis, IL 62960
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~28.89 miles east of Cairo
  • 2-star Highway property
  • 2 floors in hotel
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From£44
Average 3.0 /5 Latest Reviews Call BookMore Details
Motel 6 Metropolis Il : 2119 East 5th St. 2119 East 5th St., Metropolis, IL 62960
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~29.04 miles east of Cairo
  • Two-star property
  • Check in: 11:00 AM
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From£44
Average 3.0 /5 Read Reviews Call BookMore Details
Holiday Inn Express Metropolis by IHG 2179 East 5th St., Metropolis, IL 62960
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~29.10 miles east of Cairo
  • 3 star Rural property
  • 21 suites in hotel
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From£47
Very good 4.0 /5 Read Reviews Call BookMore Details
Hampton Inn Cape Girardeau I 55 East 207 South Mount Auburn Rd., Cape Girardeau, MO 63703
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~29.41 miles northwest of Cairo
  • Three Star Highway property
  • Check in: 3:00 pm
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From£58
Excellent 5.0 /5 Read Reviews Call BookMore Details
Victorian Inn & Suites in Cape Girardeau 3256 William St., Cape Girardeau, MO 63703
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~29.41 miles northwest of Cairo
  • Mid-scale Golf Course hotel
  • Check-in time: 3:00 pm
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From£58
Average 3.0 /5 Reviews Call BookMore Details
Auburn Place Hotel & Suites : 3265 Williams St. 3265 Williams St., Cape Girardeau, MO 63702
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~29.42 miles northwest of Cairo
  • Affordable Highway property
  • Hotel has 5 suites
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From£42
Very good 4.5 /5 Latest Reviews Call BookMore Details
Holiday Inn Express & Suites Cape Girardeau I 55 by Ihg : 3253 William St. 3253 William St., Cape Girardeau, MO 63701
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~29.49 miles northwest of Cairo
  • 3 star hotel
  • Check in time: 3:00 pm
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From£58
Very good 4.5 /5 Guest Reviews Call BookMore Details
Fairfield Inn & Suites Cape Girardeau 433 Cape West Crossing, Cape Girardeay, MO 63703
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~29.58 miles northwest of Cairo
  • Midscale hotel
  • Hotel has 22 suites
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From£58
Average 3.0 /5 Latest Reviews Call BookMore Details
Drury Suites Cape Girardeau 3303 Campster Dr., Cape Girardeau, MO 63701
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~29.72 miles northwest of Cairo
  • 3 star Highway hotel
  • Check in time: 3:00 PM
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From£62
Very good 4.5 /5 Latest Reviews Call BookMore Details
Drury Lodge - Cape Girardeau 104 South Vantage Dr., Cape Girardeau, MO 63701
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~29.82 miles northwest of Cairo
  • Three Star Highway hotel
  • Check in time: 3:00pm
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From£58
Average 3.0 /5 Hotel Reviews Call BookMore Details

Next: See My Cairo Hotels with Pricing

Graph: Upcoming 20 Days of Cairo Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Cairo, IL discounts available. The chart reflects the cheapest Cairo hotel for each day and each star rating category.

FAQs about hotels in Cairo

What are the most favored hotels in Cairo?

Hampton Inn Cape Girardeau I 55 East, Hampton Inn & Suites Paducah and Auburn Place Hotel & Suites are the best rated hotels based on customer reviews in the last 365 days.

What are the most luxurious hotels in Cairo?

Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destinatio, Quality Inn Cairo I-57 and Travel Inn & Suites - Sikeston are the top 3 luxury hotels near Cairo city center.

What hotels are closest to the city center of Cairo?

Quality Inn Cairo I-57, Super 8 by Wyndham Charleston, and Quality Inn Charleston - Sikeston are the properties closest to Cairo city center.

What are the best independent hotels in Cairo?

Auburn Place Hotel & Suites, Drury Suites Cape Girardeau and Travel Inn & Suites - Sikeston are the best rated independent hotels (not part of a big brand).

What are the most popular Marriott hotels in Cairo?

Residence Inn by Marriott Paducah, Courtyard by Marriott Cape Girardeau Downtown and Fairfield Inn & Suites by Marriott Paducah are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the best Choice Hotels branded hotels in Cairo?

Comfort Inn & Suites near Six Flags, Comfort Inn Paducah and Quality Inn & Suites Metropolis I-24 are the best rated Choice Hotels branded hotels (based on HotelPlanner reviews score).

What are the best IHG hotels in Cairo?

Holiday Inn Express & Suites Cape Girardeau I 55 by Ihg, Candlewood Suites Paducah by IHG and Candlewood Suites Cape Girardeau by IHG are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

Verified reviews of the city: Cairo, IL

Below are reviews of the city of Cairo, IL from an actual visitor's perspective.

"Spending time with my family"
Score 5.0 / 5

Vincent R., from 26-Jan-2026
The average traveler rating of the city of Cairo, IL shown above is 5.0 out of 5 based on 1 reviews
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