Cairo Illinois Accommodations

Find hotels & motels in Cairo using the list below. Search for cheap and discounted hotel and motel rates in or close to Cairo, IL for your upcoming individual or group travel. Discover the best Cairo Illinois hotel/motel rooms. Review the Cairo hotel list below to find the perfect lodging. We also have a map of the Cairo hotels.

Cairo Hotels, Motels & Accommodations

Quality Inn Cairo I-57 : 13201 Kessler Rd.
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
13201 Kessler Rd., Cairo, IL 62914 +1-888-389-4121
  • Affordable Highway property
  • Hotel has 2 floors
More Photos
From£45
Poor 2.0 /5 Read Reviews Call BookMore Details
Super 8 by Wyndham Charleston/Sikeston East MO
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
310 South Story, Charleston, MO 63834 +1-888-675-2083 ~10.14 miles southwest of Cairo
  • Low Cost Highway property
  • Check in: 3:00pm
More Photos
From£31
Average 3.5 /5 Review Score Call BookMore Details
Quality Inn Charleston - Sikeston
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
102 Drake St., Charleston, MO 63834 +1-800-716-8490 ~11.90 miles southwest of Cairo
  • Economy Highway property
  • Gym / Fitness Center Available
More Photos
From£44
Average 3.0 /5 Latest Reviews Call BookMore Details
Americas Best Value Inn Ullin Mounds
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
128 Cheekwood Lane, Ullin, IL 62992 +1-800-805-5223 ~17.90 miles north of Cairo
  • Low Cost hotel
  • Complimentary breakfast is offered
More Photos
From£45
Average 3.0 /5 Reviews Call BookMore Details
Motel 6 Sikeston Mo in SIKESTON
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
110 South Interstate Dr., SIKESTON, MO 63801 +1-888-965-1860 ~21.01 miles west of Cairo
  • 2-star property
More Photos
From£45
Average 3.0 /5 Recent Reviews Call BookMore Details
Best Western Plus Sikeston - Sikeston
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
120 South Interstate Dr., Sikeston, MO 63801 +1-888-788-5576 ~21.04 miles west of Cairo
  • Two star Highway hotel
  • Complimentary breakfast is offered
More Photos
From£32
Very good 4.0 /5 Read Reviews Call BookMore Details
Days Inn and Suites by Wyndham Sikeston
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
220 South Interstate Dr., Sikeston, MO 63801 +1-888-897-9207 ~21.11 miles west of Cairo
  • Two-star property
  • Gym / Fitness Center Available
More Photos
From£45
Average 3.0 /5 Recent Reviews Call BookMore Details
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) : 100 Matthews Lane
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
100 Matthews Lane, Sikeston, MO 63801 +1-888-311-4278 ~21.35 miles west of Cairo
  • Three Star Highway hotel
  • Free comp. breakfast
More Photos
From£60
Very good 4.0 /5 Reviews Call BookMore Details
Super 8 by Wyndham Sikeston/Miner Area - Sikeston
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
2609 East Malone, Sikeston, MO 63801 +1-888-469-4795 ~21.37 miles west of Cairo
  • Cheap Convention Center hotel
More Photos
From£45
Average 3.0 /5 Recent Reviews Call BookMore Details
Comfort Inn
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
109 Matthews Lane, Sikeston, MO 63801 +1-888-734-9421 ~21.39 miles west of Cairo
  • Midscale Highway property
  • Access to gym on-site
More Photos
From£63
Average 3.0 /5 Review Score Call BookMore Details
Drury Inn & Suites Sikeston : 2608 East Malone Ave.
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
2608 East Malone Ave., Sikeston, MO 63801 +1-888-841-5292 ~21.42 miles west of Cairo
  • Affordable Highway hotel
  • 154 sleeping rooms in hotel
More Photos
From£78
Very good 4.5 /5 Review Score Call BookMore Details
Pear Tree Inn Sikeston : 2602 East Malone
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
2602 East Malone, Sikeston, MO 63801 +1-888-455-5160 ~21.42 miles west of Cairo
  • 3 star Suburban property
  • 80 sleeping rooms in hotel
More Photos
From£60
Average 3.0 /5 Reviews Call BookMore Details
Hampton Inn Sikeston
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
1240 Commerce Dr., Sikeston, MO 63801 +1-888-965-8297 ~24.53 miles west of Cairo
  • 3 star Rural hotel
  • 8 suites in property
More Photos
From£60
Average 3.0 /5 Review Score Call BookMore Details
Holiday Inn Express & Suites Sikeston An Ihg Hotel in Sikeston
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
115 Hospitality Dr., Sikeston, MO 63801 +1-888-906-6358 ~24.55 miles west of Cairo
  • Mid-scale Rural property
  • Free breakfast
More Photos
From£60
Average 3.0 /5 Latest Reviews Call BookMore Details
Residence Inn by Marriott Paducah : 3900 Coleman Crossing Circle
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
3900 Coleman Crossing Circle, Paducah, KY 42001 +1-888-749-6785 ~25.70 miles east of Cairo
  • Affordable Suburban hotel
  • Hotel has 74 suites
More Photos
From£66
Very good 4.0 /5 Reviews Call BookMore Details
Pear Tree Inn Paducah
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
5006 Hinkleville Rd., Paducah, KY 42001 +1-888-878-9982 ~25.80 miles east of Cairo
  • 2 star Suburban hotel
  • Has environment-friendly policy See more
More Photos
From£41
Very good 4.0 /5 Read Reviews Call BookMore Details
Harrah's Metropolis Hotel & Casino - Metropolis
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
100 East Front St., Metropolis, IL 62960 +1-888-389-4485 ~26.30 miles east of Cairo
  • High end hotel
  • Check in: 16:00
More Photos
From£120
Very good 4.0 /5 Latest Reviews Call BookMore Details
Baymont by Wyndham Metropolis in Metropolis
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
203 East Front St., Metropolis, IL 62960 +1-888-389-4121 ~26.33 miles east of Cairo
  • Two star Riverfront hotel
  • Check in time: 3:00PM
More Photos
From£33
Average 3.0 /5 Review Score Call BookMore Details
Econo Lodge in Metropolis
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
1415 East 5th St., Metropolis, IL 62960 +1-888-675-2083 ~27.39 miles east of Cairo
  • Cheap property
More Photos
From£45
Terrible 1.0 /5 Guest Reviews Call BookMore Details
 Econo Lodge Paducah West I-24 in Paducah
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
5120 Hinkleville Rd., Paducah, KY 42001 +1-800-716-8490 ~27.58 miles east of Cairo
  • Economical Airport property
  • 75 rooms in hotel
More Photos
From£45
Average 3.0 /5 Hotel Reviews Call BookMore Details
Courtyard by Marriott Cape Girardeau Downtown - Cape Girardeau
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
400 Broadway St., Cape Girardeau, MO 63701 +1-800-805-5223 ~27.66 miles northwest of Cairo
  • 3 star Downtown property
  • 78 rooms in hotel
More Photos
From£60
Very good 4.0 /5 Latest Reviews Call BookMore Details
Baymont by Wyndham Paducah - Paducah
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
5300 Old Cairo Rd., Paducah, KY 42001 +1-888-965-1860 ~27.67 miles east of Cairo
  • Affordable property
  • Hotel has 74 rooms
More Photos
From£30
Poor 2.0 /5 Recent Reviews Call BookMore Details
Drury Suites Paducah in Paducah
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
2930 James Sanders Blvd., Paducah, KY 42001 +1-888-788-5576 ~27.73 miles east of Cairo
  • Mid-scale Suburban hotel
  • 6 floors in property
More Photos
From£74
Very good 4.0 /5 Review Score Call BookMore Details
Quality Suites Paducah I-24 - Paducah
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
2880 James Sanders Blvd., Paducah, KY 42001 Website +1-888-897-9207 ~27.76 miles east of Cairo
  • Low-priced Highway property
  • 59 sleeping rooms in hotel
More Photos
From£45
Average 3.0 /5 Read Reviews Call BookMore Details
Country Inn & Suites by Radisson, Paducah, KY
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
145 Mcbride Lane, Paducah, KY 42001 +1-888-311-4278 ~27.83 miles east of Cairo
  • Midscale Highway property
  • 60 sleeping rooms in hotel
More Photos
From£36
Very good 4.0 /5 Latest Reviews Call BookMore Details
Comfort Inn & Suites near Six Flags in Lithia Springs
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
960 West Pointe Court, Lithia Springs, GA 30122 Website +1-888-469-4795 ~27.83 miles east of Cairo
  • Affordable Downtown property
  • Complimentary breakfast is offered
More Photos
From£52
Very good 4.0 /5 Latest Reviews Call BookMore Details
Hotel 7 Inn
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
5001 Hinkleville Rd., Paducah, KY 42001 +1-888-734-9421 ~27.84 miles east of Cairo
  • Low priced hotel
More Photos
From£45
Average 3.0 /5 Hotel Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham Paducah : 3960 Coleman Crossing Cir
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
3960 Coleman Crossing Cir, Paducah, KY 42001 +1-888-841-5292 ~27.93 miles east of Cairo
  • Midscale Highway hotel
  • 77 rooms in property
More Photos
From£60
Average 3.0 /5 Review Score Call BookMore Details
Candlewood Suites Paducah by IHG - Paducah
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
3940 Coleman Crossing Circle, Paducah, KY 42001 +1-888-455-5160 ~27.94 miles east of Cairo
  • 3-star Rural hotel
  • Check-in time: 3:00pm
More Photos
From£45
Very good 4.0 /5 Read Reviews Call BookMore Details
Homewood Suites by Hilton Paducah - Paducah
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
3925 Coleman Crossing Cir, Paducah, KY 42001 +1-888-965-8297 ~27.97 miles east of Cairo
  • Three Star Highway property
  • Free breakfast available
More Photos
From£81
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Comfort Suites in Paducah
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
3918 Coleman Crossing Cir Paducah Ky 42001, Paducah, KY 42001 +1-888-906-6358 ~27.99 miles east of Cairo
  • Two star Rural hotel
  • Fitness + Health Center
More Photos
From£45
Average 3.0 /5 Guest Reviews Call BookMore Details
Comfort Inn Paducah
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
5135 Cairo Rd., Paducah, KY 42001 +1-888-749-6785 ~28.01 miles east of Cairo
  • Midscale hotel
  • Free comp. breakfast
More Photos
From£44
Very good 4.0 /5 Review Score Call BookMore Details
Fairfield Inn & Suites by Marriott Paducah - Paducah
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
3950 Coleman Crossing Circle, Paducah, KY 42001 +1-888-878-9982 ~28.03 miles east of Cairo
  • Mid-scale Rural hotel
  • Check-in: 3:00 pm
More Photos
From£56
Very good 4.0 /5 Guest Reviews Call BookMore Details
Red Roof Inn Paducah - Paducah
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
5106 Old Cairo Rd., Paducah, KY 42001 +1-888-389-4485 ~28.04 miles east of Cairo
  • Economical property
  • Check in time: 14:00
More Photos
From£33
Average 3.5 /5 Review Score Call BookMore Details
American Inn
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
5125 Cairo Rd., Paducah, KY 42001 +1-888-389-4121 ~28.05 miles east of Cairo
  • Cheap property
  • Free breakfast
More Photos
From£27
Very good 4.0 /5 Guest Reviews Call BookMore Details
Holiday Inn Express Hotel & Suites Paducah West by IHG : 3996 Hinkleville Rd.
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
3996 Hinkleville Rd., Paducah, KY 42001 +1-888-675-2083 ~28.07 miles east of Cairo
  • 3 star Highway property
  • Check in: 3:00 PM
More Photos
From£60
Average 3.0 /5 Latest Reviews Call BookMore Details
Auburn Place Hotel & Suites - Paducah
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
3994 Hinkleville Rd., Paducah, KY 42001 +1-800-716-8490 ~28.08 miles east of Cairo
  • Mid-scale Airport property
  • 76 rooms in property
More Photos
From£60
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Courtyard by Marriott Paducah
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
3835 Technology Dr., Paducah, KY 42001 +1-800-805-5223 ~28.32 miles east of Cairo
  • Midscale Suburban hotel
  • Check in time: 3:00 pm
More Photos
From£66
Very good 4.0 /5 Recent Reviews Call BookMore Details
Drury Inn Paducah
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
3975 Hinkleville Rd., Paducah, KY 42001 +1-888-965-1860 ~28.73 miles east of Cairo
  • Three Star Suburban property
  • Complimentary breakfast is offered
More Photos
From£59
Very good 4.5 /5 Hotel Reviews Call BookMore Details
Candlewood Suites Cape Girardeau by IHG
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
485 South Mount Auburn Rd., Cape Girardeau, MO 65703 +1-888-788-5576 ~28.78 miles northwest of Cairo
  • Inexpensive Highway hotel
  • 85 rooms in hotel
More Photos
From£51
Very good 4.0 /5 Latest Reviews Call BookMore Details
Days Inn by Wyndham Paducah in Paducah
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
3901 Hinkleville Rd., Paducah, KY 42001 +1-888-897-9207 ~28.78 miles east of Cairo
  • 2-star Highway property
  • 2 floors in property
More Photos
From£37
Average 3.0 /5 Recent Reviews Call BookMore Details
Quality Inn & Suites Metropolis I-24 - Metropolis
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
2118 East 5th St., Metropolis, IL 62960 +1-888-311-4278 ~28.90 miles east of Cairo
  • Affordable hotel
  • 52 sleeping rooms in hotel
More Photos
From£60
Very good 4.0 /5 Recent Reviews Call BookMore Details
Super 8 by Wyndham Metropolis : 2055 East 5th St.
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
2055 East 5th St., Metropolis, IL 62960 +1-888-469-4795 ~28.91 miles east of Cairo
  • Inexpensive Highway property
  • Hotel has 6 suites
More Photos
From£45
Average 3.0 /5 Guest Reviews Call BookMore Details
Travelers Inn and Suites - Paducah
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
2550 Lone Oak Rd., Paducah, KY 42003 +1-888-734-9421 ~28.91 miles east of Cairo
  • Cheap property
  • Airport shuttle available
More Photos
From£28
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Motel 6 Metropolis Il in Metropolis
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
2119 East 5th St., Metropolis, IL 62960 +1-888-841-5292 ~29.06 miles east of Cairo
  • Low-priced hotel
More Photos
From£45
Average 3.0 /5 Review Score Call BookMore Details
Holiday Inn Express Metropolis by IHG
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
2179 East 5th St., Metropolis, IL 62960 +1-888-455-5160 ~29.12 miles east of Cairo
  • Affordable Rural property
  • Hotel has 75 rooms
More Photos
From£48
Very good 4.0 /5 Read Reviews Call BookMore Details
Hampton Inn Cape Girardeau I 55 East in Cape Girardeau
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
207 South Mount Auburn Rd., Cape Girardeau, MO 63703 +1-888-965-8297 ~29.42 miles northwest of Cairo
  • Three Star Highway property
  • Check in time: 15:00
More Photos
From£60
Excellent 5.0 /5 Reviews Call BookMore Details
Victorian Inn & Suites : 3256 William St.
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
3256 William St., Cape Girardeau, MO 63703 +1-888-906-6358 ~29.43 miles northwest of Cairo
  • 3-star Golf Course property
  • Hotel has 133 rooms
More Photos
From£59
Average 3.0 /5 Recent Reviews Call BookMore Details
Auburn Place Hotel & Suites : 3265 Williams St.
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
3265 Williams St., Cape Girardeau, MO 63702 +1-888-749-6785 ~29.44 miles northwest of Cairo
  • Affordable Highway property
  • 133 rooms in hotel
More Photos
From£43
Very good 4.5 /5 Review Score Call BookMore Details
Holiday Inn Express & Suites Cape Girardeau I 55
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
3253 William St., Cape Girardeau, MO 63701 +1-888-878-9982 ~29.51 miles northwest of Cairo
  • Three Star hotel
  • 102 rooms in property
More Photos
From£60
Very good 4.5 /5 Guest Reviews Call BookMore Details

Next: See My Cairo Hotels with Pricing

Verified reviews of the city: Cairo, IL

Below are reviews of the city of Cairo, IL from an actual visitor's perspective.

""
Score 5.0 / 5

Family

Beverly T., from 10-Mar-2025
""
Score 4.0 / 5

Family

Beverly T., from 10-Mar-2025
Back to Top
Table of Contents Top: Check Rates Cairo Hotels