Cairo Illinois Accommodations

Find hotels & motels in Cairo using the list below. Search for cheap and discounted hotel and motel rates in or close to Cairo, IL for your upcoming individual or group travel. Discover the best Cairo Illinois hotel/motel rooms. Review the Cairo hotel list below to find the perfect lodging. We also have a map of the Cairo hotels.

Cairo Hotels, Motels & Accommodations

Quality Inn Cairo I-57 - Cairo 13201 Kessler Rd., Cairo, IL 62914 Call
  • 3 star Highway hotel
  • 2 floors in property
More Photos
From£44
Poor 2.0 /5 Recent Reviews Call BookMore Details
Super 8 by Wyndham Charleston/Sikeston East MO : 310 South Story 310 South Story, Charleston, MO 63834 Call ~10.13 miles southwest of Cairo
  • Economical Highway hotel
  • Check in: 3:00pm
More Photos
From£30
Average 3.5 /5 Latest Reviews Call BookMore Details
Quality Inn Charleston - Sikeston - Charleston 102 Drake St., Charleston, MO 63834 Call ~11.88 miles southwest of Cairo
  • Two-star Highway property
  • Free comp. breakfast
More Photos
From£43
Average 3.0 /5 Guest Reviews Call BookMore Details
Americas Best Value Inn Ullin Mounds 128 Cheekwood Lane, Ullin, IL 62992 Call ~17.88 miles north of Cairo
  • Cheap property
  • Comp. Breakfast
More Photos
From£44
Average 3.0 /5 Reviews Call BookMore Details
Motel 6 Sikeston Mo - SIKESTON 110 South Interstate Dr., SIKESTON, MO 63801 Call ~20.96 miles west of Cairo
  • Economical hotel
More Photos
From£44
Average 3.0 /5 Guest Reviews Call BookMore Details
Best Western Plus Sikeston in Sikeston 120 South Interstate Dr., Sikeston, MO 63801 Call ~21.00 miles west of Cairo
  • Two-star Highway hotel
  • 2 floors in property
More Photos
From£31
Very good 4.0 /5 Review Score Call BookMore Details
Days Inn and Suites by Wyndham Sikeston : 220 South Interstate Dr. 220 South Interstate Dr., Sikeston, MO 63801 Call ~21.07 miles west of Cairo
  • Economical property
  • Gym is available on property
More Photos
From£44
Average 3.0 /5 Latest Reviews Call BookMore Details
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) 100 Matthews Lane, Sikeston, MO 63801 Call ~21.31 miles west of Cairo
  • 3 star Highway hotel
  • 2 floors in hotel
More Photos
From£58
Very good 4.0 /5 Guest Reviews Call BookMore Details
Super 8 by Wyndham Sikeston/Miner Area : 2609 East Malone 2609 East Malone, Sikeston, MO 63801 Call ~21.32 miles west of Cairo
  • 2 star Convention Center hotel
  • Free breakfast
More Photos
From£44
Average 3.0 /5 Guest Reviews Call BookMore Details
Comfort Inn - Sikeston 109 Matthews Lane, Sikeston, MO 63801 Call ~21.34 miles west of Cairo
  • Mid-scale Highway hotel
  • Fitness center on property
More Photos
From£62
Average 3.0 /5 Latest Reviews Call BookMore Details
Hampton Inn Sikeston : 1240 Commerce Dr. 1240 Commerce Dr., Sikeston, MO 63801 Call ~24.48 miles west of Cairo
  • 3 star Rural hotel
  • 92 sleeping rooms in hotel
More Photos
From£58
Average 3.0 /5 Latest Reviews Call BookMore Details
Holiday Inn Express & Suites Sikeston An Ihg Hotel 115 Hospitality Dr., Sikeston, MO 63801 Call ~24.49 miles west of Cairo
  • Midscale Rural property
  • Check-in: 3:00pm
More Photos
From£58
Average 3.0 /5 Hotel Reviews Call BookMore Details
Residence Inn by Marriott Paducah 3900 Coleman Crossing Circle, Paducah, KY 42001 Call ~25.66 miles east of Cairo
  • 3-star Suburban property
  • Complimentary breakfast is offered
More Photos
From£65
Very good 4.0 /5 Latest Reviews Call BookMore Details
Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destinatio - Metropolis 100 East Front St., Metropolis, IL 62960 Call ~26.28 miles east of Cairo
  • High-end hotel
  • 12 suites in property
More Photos
From£117
Very good 4.0 /5 Review Score Call BookMore Details
Baymont by Wyndham Metropolis in Metropolis 203 East Front St., Metropolis, IL 62960 Call ~26.32 miles east of Cairo
  • Economy Riverfront property
  • 2 floors in hotel
More Photos
From£33
Average 3.0 /5 Latest Reviews Call BookMore Details
Econo Lodge 1415 East 5th St., Metropolis, IL 62960 Call ~27.38 miles east of Cairo
  • Two-star property
  • Check-in: 11:00
More Photos
From£44
Terrible 1.0 /5 Review Score Call BookMore Details
 Econo Lodge Paducah West I-24 : 5120 Hinkleville Rd. 5120 Hinkleville Rd., Paducah, KY 42001 Call ~27.55 miles east of Cairo
  • 2 star Airport property
  • Hotel has an eco-friendly policy Read more
More Photos
From£44
Average 3.0 /5 Read Reviews Call BookMore Details
Baymont by Wyndham Paducah : 5300 Old Cairo Rd. 5300 Old Cairo Rd., Paducah, KY 42001 Call ~27.64 miles east of Cairo
  • 3-star property
  • 4 suites in property
More Photos
From£29
Poor 2.0 /5 Read Reviews Call BookMore Details
Courtyard by Marriott Cape Girardeau Downtown - Cape Girardeau 400 Broadway St., Cape Girardeau, MO 63701 Call ~27.65 miles northwest of Cairo
  • Three Star Downtown hotel
  • 78 rooms in hotel
More Photos
From£58
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Drury Suites Paducah in Paducah 2930 James Sanders Blvd., Paducah, KY 42001 Call ~27.70 miles east of Cairo
  • Midscale Suburban hotel
  • 2 conference rooms in property
More Photos
From£72
Very good 4.0 /5 Review Score Call BookMore Details
Quality Suites Paducah I-24 2880 James Sanders Blvd., Paducah, KY 42001 Website Call ~27.73 miles east of Cairo
  • Two star Highway hotel
  • 59 rooms in hotel
More Photos
From£44
Average 3.0 /5 Hotel Reviews Call BookMore Details
Comfort Inn & Suites near Six Flags 960 West Pointe Court, Lithia Springs, GA 30122 Website Call ~27.80 miles east of Cairo
  • Three Star Downtown hotel
  • 5 suites in hotel
More Photos
From£51
Very good 4.0 /5 Latest Reviews Call BookMore Details
Garner Hotel Paducah West by IHG - Paducah 145 Mcbride Lane, Paducah, KY 42001 Call ~27.80 miles east of Cairo
  • Affordable Highway hotel
  • 60 rooms in property
More Photos
From£35
Very good 4.0 /5 Recent Reviews Call BookMore Details
Hotel 7 Inn Paducah in Paducah 5001 Hinkleville Rd., Paducah, KY 42001 Call ~27.81 miles east of Cairo
  • 2 star hotel
More Photos
From£44
Average 3.0 /5 Recent Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham Paducah 3960 Coleman Crossing Cir, Paducah, KY 42001 Call ~27.90 miles east of Cairo
  • Midscale Highway hotel
  • 77 rooms in hotel
More Photos
From£58
Average 3.0 /5 Read Reviews Call BookMore Details
Candlewood Suites Paducah by IHG 3940 Coleman Crossing Circle, Paducah, KY 42001 Call ~27.91 miles east of Cairo
  • Affordable Rural property
  • Hotel has an eco-friendly policy See more
More Photos
From£44
Very good 4.0 /5 Recent Reviews Call BookMore Details
Homewood Suites by Hilton Paducah - Paducah 3925 Coleman Crossing Cir, Paducah, KY 42001 Call ~27.94 miles east of Cairo
  • Midscale Highway hotel
  • 97 suites in property
More Photos
From£80
Very good 4.0 /5 Latest Reviews Call BookMore Details
Comfort Suites 3918 Coleman Crossing Cir Paducah Ky 42001, Paducah, KY 42001 Call ~27.96 miles east of Cairo
  • Low Cost Rural hotel
  • 72 rooms in property
More Photos
From£44
Average 3.0 /5 Hotel Reviews Call BookMore Details
Comfort Inn Paducah 5135 Cairo Rd., Paducah, KY 42001 Call ~27.98 miles east of Cairo
  • Mid-scale property
  • Check-in: 3:00 PM
More Photos
From£43
Very good 4.0 /5 Guest Reviews Call BookMore Details
Fairfield Inn & Suites by Marriott Paducah 3950 Coleman Crossing Circle, Paducah, KY 42001 Call ~28.01 miles east of Cairo
  • Three Star Rural property
  • Fitness + Health Center
More Photos
From£55
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Red Roof Inn Paducah : 5106 Old Cairo Rd. 5106 Old Cairo Rd., Paducah, KY 42001 Call ~28.01 miles east of Cairo
  • Two star hotel
  • 3 floors in hotel
More Photos
From£33
Average 3.5 /5 Reviews Call BookMore Details
American Inn in Paducah 5125 Cairo Rd., Paducah, KY 42001 Call ~28.02 miles east of Cairo
  • 2-star hotel
  • 2 floors in hotel
More Photos
From£27
Very good 4.0 /5 Reviews Call BookMore Details
Hampton Inn & Suites Paducah 3901 Coleman Crossing Circle, Paducah, KY 42001 Call ~28.02 miles east of Cairo
  • Midscale Highway hotel
  • Free breakfast
More Photos
From£58
Very good 4.5 /5 Recent Reviews Call BookMore Details
Holiday Inn Express Hotel & Suites Paducah West by IHG 3996 Hinkleville Rd., Paducah, KY 42001 Call ~28.04 miles east of Cairo
  • Midscale Highway property
  • Hotel has 3 floors
More Photos
From£58
Average 3.0 /5 Recent Reviews Call BookMore Details
Auburn Place Hotel & Suites - Paducah - Paducah 3994 Hinkleville Rd., Paducah, KY 42001 Call ~28.05 miles east of Cairo
  • 3-star Airport property
  • Hotel has 76 suites
More Photos
From£58
Very good 4.0 /5 Reviews Call BookMore Details
Courtyard by Marriott Paducah 3835 Technology Dr., Paducah, KY 42001 Call ~28.29 miles east of Cairo
  • 3 star Suburban property
  • Check in: 3:00 pm
More Photos
From£65
Very good 4.0 /5 Read Reviews Call BookMore Details
Days Inn by Wyndham Paducah I-24 Exit 4 3901 Hinkleville Rd., Paducah, KY 42001 Call ~28.75 miles east of Cairo
  • Low priced Highway hotel
  • Hotel has 122 rooms
More Photos
From£36
Average 3.0 /5 Read Reviews Call BookMore Details
Candlewood Suites Cape Girardeau by IHG in Cape Girardeau 485 South Mount Auburn Rd., Cape Girardeau, MO 65703 Call ~28.76 miles northwest of Cairo
  • Cheap Highway hotel
  • Hotel has an eco-friendly policy Learn more
More Photos
From£50
Very good 4.0 /5 Reviews Call BookMore Details
Travelers Inn and Suites 2550 Lone Oak Rd., Paducah, KY 42003 Call ~28.88 miles east of Cairo
  • Two star hotel
  • 33 sleeping rooms in hotel
More Photos
From£27
Very good 4.0 /5 Recent Reviews Call BookMore Details
Quality Inn & Suites Metropolis I-24 - Metropolis 2118 East 5th St., Metropolis, IL 62960 Call ~28.88 miles east of Cairo
  • Midscale property
  • Check-in time: 11:00
More Photos
From£58
Very good 4.0 /5 Review Score Call BookMore Details
Super 8 by Wyndham Metropolis - Metropolis 2055 East 5th St., Metropolis, IL 62960 Call ~28.89 miles east of Cairo
  • Low-priced Highway hotel
  • Comp. Breakfast
More Photos
From£44
Average 3.0 /5 Latest Reviews Call BookMore Details
Motel 6 Metropolis Il in Metropolis 2119 East 5th St., Metropolis, IL 62960 Call ~29.04 miles east of Cairo
  • Two-star hotel
  • Check-in: 11:00 AM
More Photos
From£44
Average 3.0 /5 Hotel Reviews Call BookMore Details
Holiday Inn Express Metropolis by IHG in Metropolis 2179 East 5th St., Metropolis, IL 62960 Call ~29.10 miles east of Cairo
  • Midscale Rural hotel
  • Hotel has 75 rooms
More Photos
From£47
Very good 4.0 /5 Recent Reviews Call BookMore Details
Hampton Inn Cape Girardeau I 55 East in Cape Girardeau 207 South Mount Auburn Rd., Cape Girardeau, MO 63703 Call ~29.41 miles northwest of Cairo
  • Affordable Highway hotel
  • Hotel has 4 floors
More Photos
From£58
Excellent 5.0 /5 Reviews Call BookMore Details
Victorian Inn & Suites 3256 William St., Cape Girardeau, MO 63703 Call ~29.41 miles northwest of Cairo
  • 3 star Golf Course property
  • 2 floors in hotel
More Photos
From£58
Average 3.0 /5 Read Reviews Call BookMore Details
Auburn Place Hotel & Suites : 3265 Williams St. 3265 Williams St., Cape Girardeau, MO 63702 Call ~29.42 miles northwest of Cairo
  • Three Star Highway property
  • 5 suites in hotel
More Photos
From£42
Very good 4.5 /5 Review Score Call BookMore Details
Holiday Inn Express & Suites Cape Girardeau I 55 by Ihg 3253 William St., Cape Girardeau, MO 63701 Call ~29.49 miles northwest of Cairo
  • Mid-scale property
  • 102 suites in hotel
More Photos
From£58
Very good 4.5 /5 Recent Reviews Call BookMore Details
Fairfield Inn & Suites Cape Girardeau : 433 Cape West Crossing 433 Cape West Crossing, Cape Girardeay, MO 63703 Call ~29.58 miles northwest of Cairo
  • Three Star hotel
  • Hotel has 22 suites
More Photos
From£58
Average 3.0 /5 Latest Reviews Call BookMore Details
Drury Suites Cape Girardeau 3303 Campster Dr., Cape Girardeau, MO 63701 Call ~29.72 miles northwest of Cairo
  • Affordable Highway property
  • Check in time: 3:00 PM
More Photos
From£62
Very good 4.5 /5 Review Score Call BookMore Details
Drury Lodge - Cape Girardeau 104 South Vantage Dr., Cape Girardeau, MO 63701 Call ~29.82 miles northwest of Cairo
  • Three Star Highway property
  • Free breakfast
More Photos
From£58
Average 3.0 /5 Read Reviews Call BookMore Details

Next: See My Cairo Hotels with Pricing

Verified reviews of the city: Cairo, IL

Below are reviews of the city of Cairo, IL from an actual visitor's perspective.

"Spending time with my family"
Score 5.0 / 5

Vincent R., from 26-Jan-2026
Back to Top
Table of Contents Top: Check Rates Cairo Hotels