Cairo Illinois Accommodations

Find hotels & motels in Cairo using the list below. Search for cheap and discounted hotel and motel rates in or close to Cairo, IL for your upcoming individual or group travel. Discover the best Cairo Illinois hotel/motel rooms. Review the Cairo hotel list below to find the perfect lodging. We also have a map of the Cairo hotels.

Cairo Hotels, Motels & Accommodations

Quality Inn Cairo I-57 - Cairo 13201 Kessler Rd., Cairo, IL 62914 Call
  • Midscale Highway property
  • Check-in time: 3 pm
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From£44
Poor 2.0 /5 Review Score Call BookMore Details
Super 8 by Wyndham Charleston/Sikeston East MO - Charleston 310 South Story, Charleston, MO 63834 Call ~10.13 miles southwest of Cairo
  • Economy Highway property
  • 7 suites in property
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From£31
Average 3.5 /5 Read Reviews Call BookMore Details
The Riverstone Hotel Charleston-Sikeston - Charleston 102 Drake St., Charleston, MO 63834 Call ~11.88 miles southwest of Cairo
  • Economy Highway property
  • Fitness / Gym is on-site
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From£43
Average 3.0 /5 Guest Reviews Call BookMore Details
Americas Best Value Inn Ullin Mounds 128 Cheekwood Lane, Ullin, IL 62992 Call ~17.88 miles north of Cairo
  • Low-priced property
  • 40 rooms in property
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From£44
Average 3.0 /5 Recent Reviews Call BookMore Details
Motel 6 Sikeston Mo - SIKESTON 110 South Interstate Dr., SIKESTON, MO 63801 Call ~20.96 miles west of Cairo
  • Two star property
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From£44
Average 3.0 /5 Hotel Reviews Call BookMore Details
Best Western Plus Sikeston in Sikeston 120 South Interstate Dr., Sikeston, MO 63801 Call ~21.00 miles west of Cairo
  • Two-star Highway property
  • Hotel has 55 rooms
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From£31
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Days Inn & Suites by Wyndham Sikeston in Sikeston 220 South Interstate Dr., Sikeston, MO 63801 Call ~21.07 miles west of Cairo
  • 2-star hotel
  • Check in: 03:00 PM
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From£44
Average 3.0 /5 Recent Reviews Call BookMore Details
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) 100 Matthews Lane, Sikeston, MO 63801 Call ~21.31 miles west of Cairo
  • Midscale Highway hotel
  • 2 floors in property
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From£59
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Super 8 by Wyndham Sikeston/Miner Area in Sikeston 2609 East Malone, Sikeston, MO 63801 Call ~21.32 miles west of Cairo
  • 2 star Convention Center property
  • Check-in time: 01:00
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From£44
Average 3.0 /5 Read Reviews Call BookMore Details
Comfort Inn - Sikeston 109 Matthews Lane, Sikeston, MO 63801 Call ~21.34 miles west of Cairo
  • Affordable Highway property
  • 64 rooms in property
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From£62
Average 3.0 /5 Review Score Call BookMore Details
Drury Inn & Suites Sikeston in Sikeston 2608 East Malone Ave., Sikeston, MO 63801 Call ~21.37 miles west of Cairo
  • Mid-scale Highway hotel
  • Hotel has 154 rooms
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From£76
Very good 4.5 /5 Reviews Call BookMore Details
Pear Tree Inn Sikeston in Sikeston 2602 East Malone, Sikeston, MO 63801 Call ~21.38 miles west of Cairo
  • Midscale Suburban property
  • Access to gym on-site
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From£59
Average 3.0 /5 Recent Reviews Call BookMore Details
Hampton Inn Sikeston 1240 Commerce Dr., Sikeston, MO 63801 Call ~24.48 miles west of Cairo
  • 3 star Rural property
  • Check-in time: 3:00 PM
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From£59
Average 3.0 /5 Latest Reviews Call BookMore Details
Holiday Inn Express & Suites Sikeston An Ihg Hotel in Sikeston 115 Hospitality Dr., Sikeston, MO 63801 Call ~24.49 miles west of Cairo
  • Midscale Rural property
  • 73 rooms in property
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From£59
Average 3.0 /5 Recent Reviews Call BookMore Details
Residence Inn by Marriott Paducah 3900 Coleman Crossing Circle, Paducah, KY 42001 Call ~25.66 miles east of Cairo
  • 3 star Suburban hotel
  • Hotel has 3 floors
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From£65
Very good 4.0 /5 Latest Reviews Call BookMore Details
Pear Tree Inn Paducah 5006 Hinkleville Rd., Paducah, KY 42001 Call ~25.77 miles east of Cairo
  • Low-priced Suburban property
  • 2 floors in hotel
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From£40
Very good 4.0 /5 Read Reviews Call BookMore Details
Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destinatio - Metropolis 100 East Front St., Metropolis, IL 62960 Call ~26.28 miles east of Cairo
  • Expensive hotel
  • Check in: 16:00
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From£118
Very good 4.0 /5 Recent Reviews Call BookMore Details
Baymont by Wyndham Metropolis in Metropolis 203 East Front St., Metropolis, IL 62960 Call ~26.32 miles east of Cairo
  • Low-priced Riverfront hotel
  • Hotel has 2 floors
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From£33
Average 3.0 /5 Read Reviews Call BookMore Details
Econo Lodge : 1415 East 5th St. 1415 East 5th St., Metropolis, IL 62960 Call ~27.38 miles east of Cairo
  • Low priced hotel
  • 45 rooms in hotel
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From£44
Terrible 1.0 /5 Reviews Call BookMore Details
 Econo Lodge Paducah West I-24 5120 Hinkleville Rd., Paducah, KY 42001 Call ~27.55 miles east of Cairo
  • Cheap Airport property
  • Check in time: 15:00pm
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From£44
Average 3.0 /5 Read Reviews Call BookMore Details
Baymont by Wyndham Paducah 5300 Old Cairo Rd., Paducah, KY 42001 Call ~27.64 miles east of Cairo
  • Affordable property
  • Hotel has 4 suites
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From£29
Poor 2.0 /5 Read Reviews Call BookMore Details
Courtyard by Marriott Cape Girardeau Downtown - Cape Girardeau 400 Broadway St., Cape Girardeau, MO 63701 Call ~27.65 miles northwest of Cairo
  • 3-star Downtown property
  • Hotel has 5 floors
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From£59
Very good 4.0 /5 Read Reviews Call BookMore Details
Drury Suites Paducah : 2930 James Sanders Blvd. 2930 James Sanders Blvd., Paducah, KY 42001 Call ~27.70 miles east of Cairo
  • Mid-scale Suburban hotel
  • Hotel has 6 floors
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From£73
Very good 4.0 /5 Latest Reviews Call BookMore Details
Quality Suites Paducah I-24 - Paducah 2880 James Sanders Blvd., Paducah, KY 42001 Website Call ~27.73 miles east of Cairo
  • Low priced Highway property
  • Has environment-friendly policy Learn more
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From£44
Average 3.0 /5 Recent Reviews Call BookMore Details
Comfort Inn & Suites near Six Flags 960 West Pointe Court, Lithia Springs, GA 30122 Website Call ~27.80 miles east of Cairo
  • 3-star Downtown hotel
  • Free breakfast
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From£51
Very good 4.0 /5 Read Reviews Call BookMore Details
Garner Hotel Paducah West by IHG - Paducah 145 Mcbride Lane, Paducah, KY 42001 Call ~27.80 miles east of Cairo
  • Midscale Highway hotel
  • 60 sleeping rooms in hotel
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From£36
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Hotel 7 Inn Paducah : 5001 Hinkleville Rd. 5001 Hinkleville Rd., Paducah, KY 42001 Call ~27.81 miles east of Cairo
  • Cheap property
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From£44
Average 3.0 /5 Hotel Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham Paducah : 3960 Coleman Crossing Cir 3960 Coleman Crossing Cir, Paducah, KY 42001 Call ~27.90 miles east of Cairo
  • 3-star Highway property
  • Hotel has an eco-friendly policy See policy
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From£59
Average 3.0 /5 Recent Reviews Call BookMore Details
Candlewood Suites Paducah by IHG - Paducah 3940 Coleman Crossing Circle, Paducah, KY 42001 Call ~27.91 miles east of Cairo
  • Mid-scale Rural hotel
  • Hotel has 4 floors
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From£44
Very good 4.0 /5 Recent Reviews Call BookMore Details
Homewood Suites by Hilton Paducah 3925 Coleman Crossing Cir, Paducah, KY 42001 Call ~27.94 miles east of Cairo
  • 3-star Highway hotel
  • Fitness + Health Center
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From£80
Very good 4.0 /5 Guest Reviews Call BookMore Details
Comfort Suites in Paducah 3918 Coleman Crossing Cir Paducah Ky 42001, Paducah, KY 42001 Call ~27.96 miles east of Cairo
  • Inexpensive Rural hotel
  • 72 rooms in property
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From£44
Average 3.0 /5 Hotel Reviews Call BookMore Details
Comfort Inn Paducah 5135 Cairo Rd., Paducah, KY 42001 Call ~27.98 miles east of Cairo
  • Three Star property
  • 2 conference rooms in property
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From£43
Very good 4.0 /5 Guest Reviews Call BookMore Details
Fairfield Inn & Suites by Marriott Paducah : 3950 Coleman Crossing Circle 3950 Coleman Crossing Circle, Paducah, KY 42001 Call ~28.01 miles east of Cairo
  • 3-star Rural hotel
  • Check in time: 3:00 pm
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From£55
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Red Roof Inn Paducah 5106 Old Cairo Rd., Paducah, KY 42001 Call ~28.01 miles east of Cairo
  • Two star property
  • Check in: 14:00
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From£33
Average 3.5 /5 Hotel Reviews Call BookMore Details
American Inn in Paducah 5125 Cairo Rd., Paducah, KY 42001 Call ~28.02 miles east of Cairo
  • Two-star property
  • Complimentary breakfast is offered
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From£27
Very good 4.0 /5 Latest Reviews Call BookMore Details
Hampton Inn & Suites Paducah in Paducah 3901 Coleman Crossing Circle, Paducah, KY 42001 Call ~28.02 miles east of Cairo
  • Midscale Highway property
  • Check in: 3:00 pm
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From£58
Very good 4.5 /5 Reviews Call BookMore Details
Holiday Inn Express Hotel & Suites Paducah West by IHG - Paducah 3996 Hinkleville Rd., Paducah, KY 42001 Call ~28.04 miles east of Cairo
  • Three Star Highway hotel
  • 85 rooms in hotel
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From£59
Average 3.0 /5 Latest Reviews Call BookMore Details
Auburn Place Hotel & Suites - Paducah : 3994 Hinkleville Rd. 3994 Hinkleville Rd., Paducah, KY 42001 Call ~28.05 miles east of Cairo
  • Affordable Airport property
  • Hotel has 76 rooms
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From£59
Very good 4.0 /5 Read Reviews Call BookMore Details
Courtyard by Marriott Paducah : 3835 Technology Dr. 3835 Technology Dr., Paducah, KY 42001 Call ~28.29 miles east of Cairo
  • Affordable Suburban property
  • Fitness center on property
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From£65
Very good 4.0 /5 Review Score Call BookMore Details
Drury Inn Paducah 3975 Hinkleville Rd., Paducah, KY 42001 Call ~28.70 miles east of Cairo
  • 3-star Suburban property
  • 5 floors in property
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From£58
Very good 4.5 /5 Review Score Call BookMore Details
Days Inn by Wyndham Paducah I-24 Exit 4 - Paducah 3901 Hinkleville Rd., Paducah, KY 42001 Call ~28.75 miles east of Cairo
  • Two-star Highway property
  • 32 suites in hotel
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From£37
Average 3.0 /5 Review Score Call BookMore Details
Candlewood Suites Cape Girardeau by IHG - Cape Girardeau 485 South Mount Auburn Rd., Cape Girardeau, MO 65703 Call ~28.76 miles northwest of Cairo
  • Economy Highway property
  • Hotel has 4 floors
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From£51
Very good 4.0 /5 Recent Reviews Call BookMore Details
Travelers Inn and Suites 2550 Lone Oak Rd., Paducah, KY 42003 Call ~28.88 miles east of Cairo
  • Cheap property
  • Check-in time: 2:00PM
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From£28
Very good 4.0 /5 Reviews Call BookMore Details
Quality Inn & Suites Metropolis I-24 in Metropolis 2118 East 5th St., Metropolis, IL 62960 Call ~28.88 miles east of Cairo
  • Three Star hotel
  • Check in: 11:00
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From£59
Very good 4.0 /5 Review Score Call BookMore Details
Super 8 by Wyndham Metropolis - Metropolis 2055 East 5th St., Metropolis, IL 62960 Call ~28.89 miles east of Cairo
  • 2-star Highway property
  • Free breakfast
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From£44
Average 3.0 /5 Hotel Reviews Call BookMore Details
Motel 6 Metropolis Il 2119 East 5th St., Metropolis, IL 62960 Call ~29.04 miles east of Cairo
  • 2-star hotel
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From£44
Average 3.0 /5 Recent Reviews Call BookMore Details
Holiday Inn Express Metropolis by IHG 2179 East 5th St., Metropolis, IL 62960 Call ~29.10 miles east of Cairo
  • Three Star Rural property
  • Gym is available on property
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From£48
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Hampton Inn Cape Girardeau I 55 East : 207 South Mount Auburn Rd. 207 South Mount Auburn Rd., Cape Girardeau, MO 63703 Call ~29.41 miles northwest of Cairo
  • 3-star Highway hotel
  • Hotel has 4 floors
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From£59
Excellent 5.0 /5 Recent Reviews Call BookMore Details
Victorian Inn & Suites 3256 William St., Cape Girardeau, MO 63703 Call ~29.41 miles northwest of Cairo
  • Three Star Golf Course hotel
  • Comp. Breakfast
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From£58
Average 3.0 /5 Guest Reviews Call BookMore Details
Auburn Place Hotel & Suites - Cape Girardeau 3265 Williams St., Cape Girardeau, MO 63702 Call ~29.42 miles northwest of Cairo
  • Midscale Highway property
  • 5 suites in property
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From£42
Very good 4.5 /5 Hotel Reviews Call BookMore Details

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Verified reviews of the city: Cairo, IL

Below are reviews of the city of Cairo, IL from an actual visitor's perspective.

"Spending time with my family"
Score 5.0 / 5

Vincent R., from 26-Jan-2026
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