Cairo Illinois Accommodations

Find hotels & motels in Cairo using the list below. Search for cheap and discounted hotel and motel rates in or close to Cairo, IL for your upcoming individual or group travel. Discover the best Cairo Illinois hotel/motel rooms. Review the Cairo hotel list below to find the perfect lodging. We also have a map of the Cairo hotels.

Cairo Hotels & Accommodations

Quality Inn Cairo I-57 : 13201 Kessler Rd. 13201 Kessler Rd., Cairo, IL 62914 Call
  • 3 star Highway hotel
  • Hotel has 2 floors
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From£44
Poor 2.0 /5 Latest Reviews Call BookMore Details
Super 8 by Wyndham Charleston/Sikeston East MO : 310 South Story 310 South Story, Charleston, MO 63834 Call ~10.13 miles southwest of Cairo
  • Low priced Highway property
  • Check-in: 3:00pm
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From£30
Average 3.5 /5 Read Reviews Call BookMore Details
Quality Inn Charleston - Sikeston in Charleston 102 Drake St., Charleston, MO 63834 Call ~11.88 miles southwest of Cairo
  • Economical Highway hotel
  • Fitness + Health Center
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From£43
Average 3.0 /5 Guest Reviews Call BookMore Details
Americas Best Value Inn Ullin Mounds in Ullin 128 Cheekwood Lane, Ullin, IL 62992 Call ~17.88 miles north of Cairo
  • Cheap property
  • Hotel has 40 rooms
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From£44
Average 3.0 /5 Recent Reviews Call BookMore Details
Motel 6 Sikeston Mo 110 South Interstate Dr., SIKESTON, MO 63801 Call ~20.96 miles west of Cairo
  • 2 star hotel
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From£44
Average 3.0 /5 Review Score Call BookMore Details
Best Western Plus Sikeston : 120 South Interstate Dr. 120 South Interstate Dr., Sikeston, MO 63801 Call ~21.00 miles west of Cairo
  • Low-priced Highway property
  • Hotel has a green policy See policy
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From£31
Very good 4.0 /5 Recent Reviews Call BookMore Details
Days Inn and Suites by Wyndham Sikeston - Sikeston 220 South Interstate Dr., Sikeston, MO 63801 Call ~21.07 miles west of Cairo
  • Two-star property
  • Check-in time: 03:00 PM
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From£44
Average 3.0 /5 Recent Reviews Call BookMore Details
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) - Sikeston 100 Matthews Lane, Sikeston, MO 63801 Call ~21.31 miles west of Cairo
  • 3-star Highway hotel
  • Free breakfast
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From£58
Very good 4.0 /5 Review Score Call BookMore Details
Super 8 by Wyndham Sikeston/Miner Area 2609 East Malone, Sikeston, MO 63801 Call ~21.32 miles west of Cairo
  • Low-priced Convention Center property
  • Complimentary breakfast is offered
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From£44
Average 3.0 /5 Guest Reviews Call BookMore Details
Comfort Inn 109 Matthews Lane, Sikeston, MO 63801 Call ~21.34 miles west of Cairo
  • 3 star Highway property
  • 64 rooms in property
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From£62
Average 3.0 /5 Read Reviews Call BookMore Details
Hampton Inn Sikeston - Sikeston 1240 Commerce Dr., Sikeston, MO 63801 Call ~24.48 miles west of Cairo
  • Midscale Rural hotel
  • 8 suites in property
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From£58
Average 3.0 /5 Recent Reviews Call BookMore Details
Holiday Inn Express & Suites Sikeston An Ihg Hotel 115 Hospitality Dr., Sikeston, MO 63801 Call ~24.49 miles west of Cairo
  • Mid-scale Rural hotel
  • Check in: 3:00pm
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From£58
Average 3.0 /5 Recent Reviews Call BookMore Details
Residence Inn by Marriott Paducah - Paducah 3900 Coleman Crossing Circle, Paducah, KY 42001 Call ~25.66 miles east of Cairo
  • Midscale Suburban hotel
  • 3 floors in property
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From£65
Very good 4.0 /5 Reviews Call BookMore Details
Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destinatio in Metropolis 100 East Front St., Metropolis, IL 62960 Call ~26.28 miles east of Cairo
  • Four-star hotel
  • Check-in time: 16:00
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From£117
Very good 4.0 /5 Reviews Call BookMore Details
Baymont by Wyndham Metropolis 203 East Front St., Metropolis, IL 62960 Call ~26.32 miles east of Cairo
  • Two star Riverfront hotel
  • Hotel has 8 suites
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From£33
Average 3.0 /5 Guest Reviews Call BookMore Details
Econo Lodge : 1415 East 5th St. 1415 East 5th St., Metropolis, IL 62960 Call ~27.38 miles east of Cairo
  • Low-priced hotel
  • Check-in: 11:00
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From£44
Terrible 1.0 /5 Recent Reviews Call BookMore Details
 Econo Lodge Paducah West I-24 5120 Hinkleville Rd., Paducah, KY 42001 Call ~27.55 miles east of Cairo
  • Two-star Airport property
  • Hotel has an eco-friendly policy See more
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From£44
Average 3.0 /5 Latest Reviews Call BookMore Details
Baymont by Wyndham Paducah : 5300 Old Cairo Rd. 5300 Old Cairo Rd., Paducah, KY 42001 Call ~27.64 miles east of Cairo
  • Three Star property
  • Hotel has 74 rooms
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From£29
Poor 2.0 /5 Reviews Call BookMore Details
Courtyard by Marriott Cape Girardeau Downtown - Cape Girardeau 400 Broadway St., Cape Girardeau, MO 63701 Call ~27.65 miles northwest of Cairo
  • 3 star Downtown hotel
  • Hotel has 78 rooms
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From£58
Very good 4.0 /5 Recent Reviews Call BookMore Details
Drury Suites Paducah : 2930 James Sanders Blvd. 2930 James Sanders Blvd., Paducah, KY 42001 Call ~27.70 miles east of Cairo
  • 3-star Suburban property
  • Check in time: 3:00 PM
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From£72
Very good 4.0 /5 Reviews Call BookMore Details
Quality Suites Paducah I-24 in Paducah 2880 James Sanders Blvd., Paducah, KY 42001 Website Call ~27.73 miles east of Cairo
  • Economical Highway hotel
  • Free comp. breakfast
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From£44
Average 3.0 /5 Hotel Reviews Call BookMore Details
Comfort Inn & Suites near Six Flags - Lithia Springs 960 West Pointe Court, Lithia Springs, GA 30122 Website Call ~27.80 miles east of Cairo
  • 3 star Downtown hotel
  • Free breakfast
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From£51
Very good 4.0 /5 Review Score Call BookMore Details
Garner Hotel Paducah West by IHG 145 Mcbride Lane, Paducah, KY 42001 Call ~27.80 miles east of Cairo
  • 3 star Highway hotel
  • Check-in: 3pm
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From£35
Very good 4.0 /5 Reviews Call BookMore Details
Hotel 7 Inn Paducah 5001 Hinkleville Rd., Paducah, KY 42001 Call ~27.81 miles east of Cairo
  • Low-priced property
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From£44
Average 3.0 /5 Latest Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham Paducah 3960 Coleman Crossing Cir, Paducah, KY 42001 Call ~27.90 miles east of Cairo
  • 3 star Highway hotel
  • 26 suites in property
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From£58
Average 3.0 /5 Latest Reviews Call BookMore Details
Candlewood Suites Paducah by IHG 3940 Coleman Crossing Circle, Paducah, KY 42001 Call ~27.91 miles east of Cairo
  • Mid-scale Rural hotel
  • Hotel has 4 floors
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From£44
Very good 4.0 /5 Guest Reviews Call BookMore Details
Homewood Suites by Hilton Paducah 3925 Coleman Crossing Cir, Paducah, KY 42001 Call ~27.94 miles east of Cairo
  • Affordable Highway property
  • Free breakfast available
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From£80
Very good 4.0 /5 Latest Reviews Call BookMore Details
Comfort Suites 3918 Coleman Crossing Cir Paducah Ky 42001, Paducah, KY 42001 Call ~27.96 miles east of Cairo
  • Cheap Rural property
  • Gym is available on property
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From£44
Average 3.0 /5 Hotel Reviews Call BookMore Details
Comfort Inn Paducah 5135 Cairo Rd., Paducah, KY 42001 Call ~27.98 miles east of Cairo
  • Three Star hotel
  • Access to gym on-site
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From£43
Very good 4.0 /5 Guest Reviews Call BookMore Details
Fairfield Inn & Suites by Marriott Paducah in Paducah 3950 Coleman Crossing Circle, Paducah, KY 42001 Call ~28.01 miles east of Cairo
  • Mid-scale Rural property
  • Complimentary breakfast is offered
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From£55
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Red Roof Inn Paducah in Paducah 5106 Old Cairo Rd., Paducah, KY 42001 Call ~28.01 miles east of Cairo
  • Low-priced hotel
  • 8 suites in hotel
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From£33
Average 3.5 /5 Recent Reviews Call BookMore Details
American Inn 5125 Cairo Rd., Paducah, KY 42001 Call ~28.02 miles east of Cairo
  • Two-star property
  • Check-in: 14:00
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From£27
Very good 4.0 /5 Reviews Call BookMore Details
Hampton Inn & Suites Paducah 3901 Coleman Crossing Circle, Paducah, KY 42001 Call ~28.02 miles east of Cairo
  • 3 star Highway property
  • Fitness + Health Center
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From£58
Very good 4.5 /5 Latest Reviews Call BookMore Details
Holiday Inn Express Hotel & Suites Paducah West by IHG - Paducah 3996 Hinkleville Rd., Paducah, KY 42001 Call ~28.04 miles east of Cairo
  • Affordable Highway hotel
  • 3 floors in property
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From£58
Average 3.0 /5 Latest Reviews Call BookMore Details
Auburn Place Hotel & Suites - Paducah 3994 Hinkleville Rd., Paducah, KY 42001 Call ~28.05 miles east of Cairo
  • 3 star Airport property
  • 76 rooms in hotel
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From£58
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Courtyard by Marriott Paducah 3835 Technology Dr., Paducah, KY 42001 Call ~28.29 miles east of Cairo
  • Three Star Suburban hotel
  • 3 suites in hotel
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From£65
Very good 4.0 /5 Reviews Call BookMore Details
Days Inn by Wyndham Paducah I-24 Exit 4 3901 Hinkleville Rd., Paducah, KY 42001 Call ~28.75 miles east of Cairo
  • Low-priced Highway property
  • Free breakfast
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From£36
Average 3.0 /5 Reviews Call BookMore Details
Candlewood Suites Cape Girardeau by IHG in Cape Girardeau 485 South Mount Auburn Rd., Cape Girardeau, MO 65703 Call ~28.76 miles northwest of Cairo
  • Cheap Highway hotel
  • Fitness + Health Center
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From£50
Very good 4.0 /5 Guest Reviews Call BookMore Details
Travelers Inn and Suites in Paducah 2550 Lone Oak Rd., Paducah, KY 42003 Call ~28.88 miles east of Cairo
  • 2 star hotel
  • Check in time: 2:00PM
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From£27
Very good 4.0 /5 Review Score Call BookMore Details
Quality Inn & Suites Metropolis I-24 2118 East 5th St., Metropolis, IL 62960 Call ~28.88 miles east of Cairo
  • 3 star property
  • Hotel has 52 rooms
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From£58
Very good 4.0 /5 Latest Reviews Call BookMore Details
Super 8 by Wyndham Metropolis : 2055 East 5th St. 2055 East 5th St., Metropolis, IL 62960 Call ~28.89 miles east of Cairo
  • Two-star Highway hotel
  • 6 suites in hotel
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From£44
Average 3.0 /5 Read Reviews Call BookMore Details
Motel 6 Metropolis Il in Metropolis 2119 East 5th St., Metropolis, IL 62960 Call ~29.04 miles east of Cairo
  • Two star property
  • Check-in time: 11:00 AM
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From£44
Average 3.0 /5 Read Reviews Call BookMore Details
Holiday Inn Express Metropolis by IHG - Metropolis 2179 East 5th St., Metropolis, IL 62960 Call ~29.10 miles east of Cairo
  • Affordable Rural hotel
  • Free breakfast
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From£47
Very good 4.0 /5 Reviews Call BookMore Details
Hampton Inn Cape Girardeau I 55 East in Cape Girardeau 207 South Mount Auburn Rd., Cape Girardeau, MO 63703 Call ~29.41 miles northwest of Cairo
  • Mid-scale Highway property
  • 4 floors in hotel
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From£58
Excellent 5.0 /5 Recent Reviews Call BookMore Details
Victorian Inn & Suites in Cape Girardeau 3256 William St., Cape Girardeau, MO 63703 Call ~29.41 miles northwest of Cairo
  • 3-star Golf Course property
  • 2 floors in property
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From£58
Average 3.0 /5 Guest Reviews Call BookMore Details
Auburn Place Hotel & Suites : 3265 Williams St. 3265 Williams St., Cape Girardeau, MO 63702 Call ~29.42 miles northwest of Cairo
  • 3 star Highway hotel
  • Fitness center on property
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From£42
Very good 4.5 /5 Recent Reviews Call BookMore Details
Holiday Inn Express & Suites Cape Girardeau I 55 by Ihg 3253 William St., Cape Girardeau, MO 63701 Call ~29.49 miles northwest of Cairo
  • Three Star property
  • 102 rooms in property
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From£58
Very good 4.5 /5 Reviews Call BookMore Details
Fairfield Inn & Suites Cape Girardeau 433 Cape West Crossing, Cape Girardeay, MO 63703 Call ~29.58 miles northwest of Cairo
  • 3-star hotel
  • 4 floors in property
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From£58
Average 3.0 /5 Latest Reviews Call BookMore Details
Drury Suites Cape Girardeau 3303 Campster Dr., Cape Girardeau, MO 63701 Call ~29.72 miles northwest of Cairo
  • 3 star Highway hotel
  • 86 rooms in hotel
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From£62
Very good 4.5 /5 Reviews Call BookMore Details
Drury Lodge : 104 South Vantage Dr. 104 South Vantage Dr., Cape Girardeau, MO 63701 Call ~29.82 miles northwest of Cairo
  • Midscale Highway hotel
  • Free breakfast available
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From£58
Average 3.0 /5 Latest Reviews Call BookMore Details

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Verified reviews of the city: Cairo, IL

Below are reviews of the city of Cairo, IL from an actual visitor's perspective.

"Spending time with my family"
Score 5.0 / 5

Vincent R., from 26-Jan-2026
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