Cairo Illinois Accommodations

Find hotels & motels in Cairo using the list below. Search for cheap and discounted hotel and motel rates in or close to Cairo, IL for your upcoming individual or group travel. Discover the best Cairo Illinois hotel/motel rooms. Review the Cairo hotel list below to find the perfect lodging. We also have a map of the Cairo hotels.

Cairo Hotels/Motels & Accommodations

Quality Inn Cairo I-57 - Cairo
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
13201 Kessler Rd., Cairo, IL 62914 +1-888-389-4121
  • Three Star Highway property
  • Hotel has 2 floors
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From£43
Poor 2.0 /5 Recent Reviews Call BookMore Details
Super 8 by Wyndham Charleston/Sikeston East MO
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
310 South Story, Charleston, MO 63834 +1-888-675-2083 ~10.14 miles southwest of Cairo
  • Two star Highway property
  • 7 suites in hotel
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From£30
Average 3.5 /5 Recent Reviews Call BookMore Details
Quality Inn Charleston - Sikeston in Charleston
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
102 Drake St., Charleston, MO 63834 +1-800-716-8490 ~11.90 miles southwest of Cairo
  • Cheap Highway hotel
  • Free comp. breakfast
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From£42
Average 3.0 /5 Reviews Call BookMore Details
Americas Best Value Inn Ullin Mounds
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
128 Cheekwood Lane, Ullin, IL 62992 +1-800-805-5223 ~17.90 miles north of Cairo
  • Economical hotel
  • Check in: 15:00
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From£43
Average 3.0 /5 Review Score Call BookMore Details
Motel 6 Sikeston Mo - SIKESTON
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
110 South Interstate Dr., SIKESTON, MO 63801 +1-888-965-1860 ~21.01 miles west of Cairo
  • Two-star hotel
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From£43
Average 3.0 /5 Review Score Call BookMore Details
Best Western Plus Sikeston : 120 South Interstate Dr.
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
120 South Interstate Dr., Sikeston, MO 63801 +1-888-788-5576 ~21.04 miles west of Cairo
  • Low priced Highway hotel
  • 2 floors in property
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From£31
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Days Inn and Suites by Wyndham Sikeston
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
220 South Interstate Dr., Sikeston, MO 63801 +1-888-897-9207 ~21.11 miles west of Cairo
  • Economical property
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From£43
Average 3.0 /5 Guest Reviews Call BookMore Details
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) - Sikeston
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
100 Matthews Lane, Sikeston, MO 63801 +1-888-311-4278 ~21.35 miles west of Cairo
  • 3 star Highway hotel
  • Check in: 3:00 PM
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From£58
Very good 4.0 /5 Review Score Call BookMore Details
Super 8 by Wyndham Sikeston/Miner Area
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
2609 East Malone, Sikeston, MO 63801 +1-888-469-4795 ~21.37 miles west of Cairo
  • Two-star Convention Center hotel
  • Free breakfast
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From£43
Average 3.0 /5 Review Score Call BookMore Details
Comfort Inn - Sikeston
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
109 Matthews Lane, Sikeston, MO 63801 +1-888-734-9421 ~21.39 miles west of Cairo
  • 3-star Highway property
  • Gym / Fitness Center Available
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From£61
Average 3.0 /5 Recent Reviews Call BookMore Details
Drury Inn & Suites Sikeston
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
2608 East Malone Ave., Sikeston, MO 63801 +1-888-841-5292 ~21.42 miles west of Cairo
  • 3 star Highway property
  • Free breakfast
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From£75
Very good 4.5 /5 Reviews Call BookMore Details
Pear Tree Inn Sikeston - Sikeston
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
2602 East Malone, Sikeston, MO 63801 +1-888-455-5160 ~21.42 miles west of Cairo
  • 3-star Suburban property
  • Hotel has 2 suites
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From£58
Average 3.0 /5 Reviews Call BookMore Details
Hampton Inn Sikeston
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
1240 Commerce Dr., Sikeston, MO 63801 +1-888-965-8297 ~24.53 miles west of Cairo
  • Three Star Rural property
  • Free breakfast
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From£58
Average 3.0 /5 Review Score Call BookMore Details
Holiday Inn Express & Suites Sikeston An Ihg Hotel - Sikeston
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
115 Hospitality Dr., Sikeston, MO 63801 +1-888-906-6358 ~24.55 miles west of Cairo
  • Midscale Rural property
  • Free breakfast
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From£58
Average 3.0 /5 Review Score Call BookMore Details
Residence Inn by Marriott Paducah : 3900 Coleman Crossing Circle
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
3900 Coleman Crossing Circle, Paducah, KY 42001 +1-888-749-6785 ~25.70 miles east of Cairo
  • 3-star Suburban property
  • Free breakfast
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From£64
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Pear Tree Inn Paducah
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
5006 Hinkleville Rd., Paducah, KY 42001 +1-888-878-9982 ~25.80 miles east of Cairo
  • Low-priced Suburban property
  • 2 floors in hotel
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From£39
Very good 4.0 /5 Read Reviews Call BookMore Details
Harrah's Metropolis Hotel & Casino : 100 East Front St.
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
100 East Front St., Metropolis, IL 62960 +1-888-389-4485 ~26.30 miles east of Cairo
  • High end property
  • Hotel has 252 rooms
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From£116
Very good 4.0 /5 Latest Reviews Call BookMore Details
Baymont by Wyndham Metropolis
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
203 East Front St., Metropolis, IL 62960 +1-888-389-4121 ~26.33 miles east of Cairo
  • Cheap Riverfront hotel
  • 117 sleeping rooms in hotel
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From£32
Average 3.0 /5 Latest Reviews Call BookMore Details
Econo Lodge
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
1415 East 5th St., Metropolis, IL 62960 +1-888-675-2083 ~27.39 miles east of Cairo
  • Low priced property
  • 45 sleeping rooms in hotel
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From£43
Terrible 1.0 /5 Latest Reviews Call BookMore Details
 Econo Lodge Paducah West I-24 : 5120 Hinkleville Rd.
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
5120 Hinkleville Rd., Paducah, KY 42001 +1-800-716-8490 ~27.58 miles east of Cairo
  • Low Cost Airport hotel
  • Check in: 15:00pm
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From£43
Average 3.0 /5 Hotel Reviews Call BookMore Details
Courtyard by Marriott Cape Girardeau Downtown in Cape Girardeau
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
400 Broadway St., Cape Girardeau, MO 63701 +1-800-805-5223 ~27.66 miles northwest of Cairo
  • Mid-scale Downtown hotel
  • 13 suites in hotel
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From£58
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Baymont by Wyndham Paducah in Paducah
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
5300 Old Cairo Rd., Paducah, KY 42001 +1-888-965-1860 ~27.67 miles east of Cairo
  • Mid-scale hotel
  • Check-in: 15:00
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From£29
Poor 2.0 /5 Latest Reviews Call BookMore Details
Drury Suites Paducah in Paducah
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
2930 James Sanders Blvd., Paducah, KY 42001 +1-888-788-5576 ~27.73 miles east of Cairo
  • Affordable Suburban property
  • Check in time: 3:00 PM
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From£71
Very good 4.0 /5 Latest Reviews Call BookMore Details
Quality Suites Paducah I-24
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
2880 James Sanders Blvd., Paducah, KY 42001 Website +1-888-897-9207 ~27.76 miles east of Cairo
  • Two-star Highway hotel
  • 59 rooms in hotel
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From£43
Average 3.0 /5 Recent Reviews Call BookMore Details
Country Inn & Suites by Radisson, Paducah, KY
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
145 Mcbride Lane, Paducah, KY 42001 +1-888-311-4278 ~27.83 miles east of Cairo
  • Affordable Highway property
  • 60 sleeping rooms in hotel
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From£35
Very good 4.0 /5 Latest Reviews Call BookMore Details
Comfort Inn & Suites near Six Flags : 960 West Pointe Court
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
960 West Pointe Court, Lithia Springs, GA 30122 Website +1-888-469-4795 ~27.83 miles east of Cairo
  • Three Star Downtown hotel
  • Check in: 3:00pm
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From£50
Very good 4.0 /5 Review Score Call BookMore Details
Hotel 7 Inn Paducah : 5001 Hinkleville Rd.
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
5001 Hinkleville Rd., Paducah, KY 42001 +1-888-734-9421 ~27.84 miles east of Cairo
  • Economy property
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From£43
Average 3.0 /5 Recent Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham Paducah
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
3960 Coleman Crossing Cir, Paducah, KY 42001 +1-888-841-5292 ~27.93 miles east of Cairo
  • 3-star Highway hotel
  • 77 rooms in property
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From£58
Average 3.0 /5 Reviews Call BookMore Details
Candlewood Suites Paducah by IHG in Paducah
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
3940 Coleman Crossing Circle, Paducah, KY 42001 +1-888-455-5160 ~27.94 miles east of Cairo
  • Affordable Rural property
  • 85 suites in hotel
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From£43
Very good 4.0 /5 Read Reviews Call BookMore Details
Homewood Suites by Hilton Paducah : 3925 Coleman Crossing Cir
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
3925 Coleman Crossing Cir, Paducah, KY 42001 +1-888-965-8297 ~27.97 miles east of Cairo
  • Affordable Highway hotel
  • Hotel has 97 rooms
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From£79
Very good 4.0 /5 Latest Reviews Call BookMore Details
Comfort Suites
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
3918 Coleman Crossing Cir Paducah Ky 42001, Paducah, KY 42001 +1-888-906-6358 ~27.99 miles east of Cairo
  • 2 star Rural hotel
  • Check in: 3:00pm
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From£43
Average 3.0 /5 Read Reviews Call BookMore Details
Comfort Inn Paducah : 5135 Cairo Rd.
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
5135 Cairo Rd., Paducah, KY 42001 +1-888-749-6785 ~28.01 miles east of Cairo
  • Midscale property
  • 64 suites in property
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From£42
Very good 4.0 /5 Reviews Call BookMore Details
Fairfield Inn & Suites by Marriott Paducah
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
3950 Coleman Crossing Circle, Paducah, KY 42001 +1-888-878-9982 ~28.03 miles east of Cairo
  • 3 star Rural property
  • 82 rooms in property
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From£54
Very good 4.0 /5 Guest Reviews Call BookMore Details
Red Roof Inn Paducah - Paducah
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
5106 Old Cairo Rd., Paducah, KY 42001 +1-888-389-4485 ~28.04 miles east of Cairo
  • Two star property
  • 8 suites in hotel
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From£32
Average 3.5 /5 Latest Reviews Call BookMore Details
American Inn : 5125 Cairo Rd.
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
5125 Cairo Rd., Paducah, KY 42001 +1-888-389-4121 ~28.05 miles east of Cairo
  • Low Cost hotel
  • Check in: 14:00
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From£26
Very good 4.0 /5 Guest Reviews Call BookMore Details
Holiday Inn Express Hotel & Suites Paducah West by IHG in Paducah
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
3996 Hinkleville Rd., Paducah, KY 42001 +1-888-675-2083 ~28.07 miles east of Cairo
  • 3 star Highway property
  • Check-in: 3:00 PM
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From£58
Average 3.0 /5 Latest Reviews Call BookMore Details
Auburn Place Hotel & Suites - Paducah
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
3994 Hinkleville Rd., Paducah, KY 42001 +1-800-716-8490 ~28.08 miles east of Cairo
  • Three Star Airport hotel
  • 3 floors in hotel
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From£58
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Courtyard by Marriott Paducah
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
3835 Technology Dr., Paducah, KY 42001 +1-800-805-5223 ~28.32 miles east of Cairo
  • Mid-scale Suburban property
  • Check-in: 3:00 pm
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From£64
Very good 4.0 /5 Read Reviews Call BookMore Details
Drury Inn Paducah in Paducah
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
3975 Hinkleville Rd., Paducah, KY 42001 +1-888-965-1860 ~28.73 miles east of Cairo
  • 3-star Suburban property
  • Comp. Breakfast
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From£57
Very good 4.5 /5 Reviews Call BookMore Details
Candlewood Suites Cape Girardeau by IHG - Cape Girardeau
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
485 South Mount Auburn Rd., Cape Girardeau, MO 65703 +1-888-788-5576 ~28.78 miles northwest of Cairo
  • Cheap Highway property
  • 4 floors in property
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From£50
Very good 4.0 /5 Latest Reviews Call BookMore Details
Days Inn by Wyndham Paducah I-24 Exit 4 : 3901 Hinkleville Rd.
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
3901 Hinkleville Rd., Paducah, KY 42001 +1-888-897-9207 ~28.78 miles east of Cairo
  • Low Cost Highway property
  • Hotel has 2 floors
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From£36
Average 3.0 /5 Reviews Call BookMore Details
Quality Inn & Suites Metropolis I-24
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
2118 East 5th St., Metropolis, IL 62960 +1-888-311-4278 ~28.90 miles east of Cairo
  • Midscale property
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From£58
Very good 4.0 /5 Read Reviews Call BookMore Details
Super 8 by Wyndham Metropolis - Metropolis
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
2055 East 5th St., Metropolis, IL 62960 +1-888-469-4795 ~28.91 miles east of Cairo
  • Low-priced Highway property
  • Check in: 02:00PM
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From£43
Average 3.0 /5 Recent Reviews Call BookMore Details
Travelers Inn and Suites
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
2550 Lone Oak Rd., Paducah, KY 42003 +1-888-734-9421 ~28.91 miles east of Cairo
  • Cheap property
  • 30 suites in property
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From£27
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Motel 6 Metropolis Il - Metropolis
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
2119 East 5th St., Metropolis, IL 62960 +1-888-841-5292 ~29.06 miles east of Cairo
  • Two star property
  • Check in time: 11:00 AM
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From£43
Average 3.0 /5 Hotel Reviews Call BookMore Details
Holiday Inn Express Metropolis by IHG in Metropolis
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
2179 East 5th St., Metropolis, IL 62960 +1-888-455-5160 ~29.12 miles east of Cairo
  • Affordable Rural hotel
  • Fitness center on property
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From£47
Very good 4.0 /5 Recent Reviews Call BookMore Details
Hampton Inn Cape Girardeau I 55 East
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
207 South Mount Auburn Rd., Cape Girardeau, MO 63703 +1-888-965-8297 ~29.42 miles northwest of Cairo
  • Mid-scale Highway property
  • Check in: 15:00
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From£58
Excellent 5.0 /5 Review Score Call BookMore Details
Victorian Inn & Suites : 3256 William St.
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
3256 William St., Cape Girardeau, MO 63703 +1-888-906-6358 ~29.43 miles northwest of Cairo
  • Affordable Golf Course property
  • 2 floors in hotel
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From£57
Average 3.0 /5 Hotel Reviews Call BookMore Details
Auburn Place Hotel & Suites - Cape Girardeau
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
3265 Williams St., Cape Girardeau, MO 63702 +1-888-749-6785 ~29.44 miles northwest of Cairo
  • Three Star Highway property
  • Hotel has 2 floors
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From£42
Very good 4.5 /5 Recent Reviews Call BookMore Details
Holiday Inn Express & Suites Cape Girardeau I 55
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
3253 William St., Cape Girardeau, MO 63701 +1-888-878-9982 ~29.51 miles northwest of Cairo
  • Midscale property
  • Hotel has 102 suites
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From£58
Very good 4.5 /5 Recent Reviews Call BookMore Details

Next: See My Cairo Hotels with Pricing

Verified reviews of the city: Cairo, IL

Below are reviews of the city of Cairo, IL from an actual visitor's perspective.

""
Score 5.0 / 5

Family

Beverly T., from 10-Mar-2025
""
Score 4.0 / 5

Family

Beverly T., from 10-Mar-2025
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