Cairo Illinois Accommodations

Find hotels & motels in Cairo using the list below. Search for cheap and discounted hotel and motel rates in or close to Cairo, IL for your upcoming individual or group travel. Discover the best Cairo Illinois hotel/motel rooms. Review the Cairo hotel list below to find the perfect lodging. We also have a map of the Cairo hotels.

Cairo Hotels/Motels & Accommodations

Quality Inn Cairo I-57 in Cairo 13201 Kessler Rd., Cairo, IL 62914 Call
  • Affordable Highway property
  • Check-in time: 3 pm
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From£53 total
Poor 2.0 /5 Guest Reviews Call BookMore Details
Super 8 by Wyndham Charleston/Sikeston East MO - Charleston 310 South Story, Charleston, MO 63834 Call ~10.13 miles southwest of Cairo
  • Economical Highway property
  • Check-in time: 3:00pm
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From£37 total
Average 3.5 /5 Recent Reviews Call BookMore Details
The Riverstone Hotel Charleston-Sikeston - Charleston 102 Drake St., Charleston, MO 63834 Call ~11.88 miles southwest of Cairo
  • Low priced Highway hotel
  • 9 suites in hotel
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From£52 total
Average 3.0 /5 Latest Reviews Call BookMore Details
Americas Best Value Inn Ullin Mounds - Ullin 128 Cheekwood Lane, Ullin, IL 62992 Call ~17.88 miles north of Cairo
  • Two star property
  • Free breakfast
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From£53 total
Average 3.0 /5 Hotel Reviews Call BookMore Details
Motel 6 Sikeston Mo 110 South Interstate Dr., SIKESTON, MO 63801 Call ~20.96 miles west of Cairo
  • 2-star hotel
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From£53 total
Average 3.0 /5 Latest Reviews Call BookMore Details
Best Western Plus Sikeston in Sikeston 120 South Interstate Dr., Sikeston, MO 63801 Call ~21.00 miles west of Cairo
  • Low Cost Highway property
  • 2 floors in property
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From£37 total
Very good 4.0 /5 Recent Reviews Call BookMore Details
Days Inn and Suites by Wyndham Sikeston in Sikeston 220 South Interstate Dr., Sikeston, MO 63801 Call ~21.07 miles west of Cairo
  • Two-star property
  • Check in: 03:00 PM
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From£53 total
Average 3.0 /5 Read Reviews Call BookMore Details
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) - Sikeston 100 Matthews Lane, Sikeston, MO 63801 Call ~21.31 miles west of Cairo
  • Three Star Highway property
  • Free breakfast available
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From£70 total
Very good 4.0 /5 Review Score Call BookMore Details
Super 8 by Wyndham Sikeston/Miner Area - Sikeston 2609 East Malone, Sikeston, MO 63801 Call ~21.32 miles west of Cairo
  • Inexpensive Convention Center hotel
  • Free complimentary breakfast
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From£53 total
Average 3.0 /5 Hotel Reviews Call BookMore Details
Comfort Inn 109 Matthews Lane, Sikeston, MO 63801 Call ~21.34 miles west of Cairo
  • 3 star Highway hotel
  • Fitness center on property
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From£75 total
Average 3.0 /5 Guest Reviews Call BookMore Details
Hampton Inn Sikeston in Sikeston 1240 Commerce Dr., Sikeston, MO 63801 Call ~24.48 miles west of Cairo
  • Three Star Rural property
  • Check-in: 3:00 PM
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From£70 total
Average 3.0 /5 Latest Reviews Call BookMore Details
Holiday Inn Express & Suites Sikeston An Ihg Hotel 115 Hospitality Dr., Sikeston, MO 63801 Call ~24.49 miles west of Cairo
  • 3 star Rural property
  • Check-in time: 3:00pm
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From£70 total
Average 3.0 /5 Recent Reviews Call BookMore Details
Residence Inn by Marriott Paducah 3900 Coleman Crossing Circle, Paducah, KY 42001 Call ~25.66 miles east of Cairo
  • 3 star Suburban property
  • Hotel has 3 floors
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From£78 total
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destinatio in Metropolis 100 East Front St., Metropolis, IL 62960 Call ~26.28 miles east of Cairo
  • Expensive property
  • 12 suites in hotel
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From£141 total
Very good 4.0 /5 Latest Reviews Call BookMore Details
Baymont by Wyndham Metropolis - Metropolis 203 East Front St., Metropolis, IL 62960 Call ~26.32 miles east of Cairo
  • Low Cost Riverfront property
  • Hotel has 8 suites
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From£39 total
Average 3.0 /5 Reviews Call BookMore Details
Econo Lodge 1415 East 5th St., Metropolis, IL 62960 Call ~27.38 miles east of Cairo
  • 2-star property
  • 45 sleeping rooms in hotel
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From£53 total
Terrible 1.0 /5 Recent Reviews Call BookMore Details
 Econo Lodge Paducah West I-24 5120 Hinkleville Rd., Paducah, KY 42001 Call ~27.55 miles east of Cairo
  • Economical Airport property
  • Hotel has an eco-friendly policy Learn more
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From£53 total
Average 3.0 /5 Guest Reviews Call BookMore Details
Baymont by Wyndham Paducah - Paducah 5300 Old Cairo Rd., Paducah, KY 42001 Call ~27.64 miles east of Cairo
  • 3-star hotel
  • Check in: 15:00
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From£35 total
Poor 2.0 /5 Latest Reviews Call BookMore Details
Courtyard by Marriott Cape Girardeau Downtown - Cape Girardeau 400 Broadway St., Cape Girardeau, MO 63701 Call ~27.65 miles northwest of Cairo
  • 3 star Downtown hotel
  • 5 floors in property
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From£70 total
Very good 4.0 /5 Read Reviews Call BookMore Details
Quality Suites Paducah I-24 : 2880 James Sanders Blvd. 2880 James Sanders Blvd., Paducah, KY 42001 Website Call ~27.73 miles east of Cairo
  • Cheap Highway property
  • Hotel has 2 floors
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From£53 total
Average 3.0 /5 Recent Reviews Call BookMore Details
Comfort Inn & Suites near Six Flags 960 West Pointe Court, Lithia Springs, GA 30122 Website Call ~27.80 miles east of Cairo
  • 3 star Downtown hotel
  • Comp. Breakfast
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From£61 total
Very good 4.0 /5 Review Score Call BookMore Details
Garner Hotel Paducah West by IHG : 145 Mcbride Lane 145 Mcbride Lane, Paducah, KY 42001 Call ~27.80 miles east of Cairo
  • Three Star Highway property
  • 17 suites in hotel
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From£43 total
Very good 4.0 /5 Reviews Call BookMore Details
Hotel 7 Inn Paducah 5001 Hinkleville Rd., Paducah, KY 42001 Call ~27.81 miles east of Cairo
  • Cheap hotel
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From£53 total
Average 3.0 /5 Guest Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham Paducah - Paducah 3960 Coleman Crossing Cir, Paducah, KY 42001 Call ~27.90 miles east of Cairo
  • 3 star Highway hotel
  • 4 floors in hotel
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From£70 total
Average 3.0 /5 Recent Reviews Call BookMore Details
Candlewood Suites Paducah by IHG : 3940 Coleman Crossing Circle 3940 Coleman Crossing Circle, Paducah, KY 42001 Call ~27.91 miles east of Cairo
  • Mid-scale Rural property
  • Has environment-friendly policy Read more
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From£53 total
Very good 4.0 /5 Reviews Call BookMore Details
Homewood Suites by Hilton Paducah - Paducah 3925 Coleman Crossing Cir, Paducah, KY 42001 Call ~27.94 miles east of Cairo
  • Three Star Highway property
  • 97 rooms in hotel
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From£96 total
Very good 4.0 /5 Latest Reviews Call BookMore Details
Comfort Suites 3918 Coleman Crossing Cir Paducah Ky 42001, Paducah, KY 42001 Call ~27.96 miles east of Cairo
  • 2 star Rural property
  • Gym is available on property
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From£53 total
Average 3.0 /5 Review Score Call BookMore Details
Comfort Inn Paducah 5135 Cairo Rd., Paducah, KY 42001 Call ~27.98 miles east of Cairo
  • Affordable property
  • Hotel has 64 suites
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From£52 total
Very good 4.0 /5 Read Reviews Call BookMore Details
Fairfield Inn & Suites by Marriott Paducah 3950 Coleman Crossing Circle, Paducah, KY 42001 Call ~28.01 miles east of Cairo
  • 3-star Rural hotel
  • Check-in: 3:00 pm
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From£66 total
Very good 4.0 /5 Guest Reviews Call BookMore Details
Red Roof Inn Paducah in Paducah 5106 Old Cairo Rd., Paducah, KY 42001 Call ~28.01 miles east of Cairo
  • Economical hotel
  • Hotel has 3 floors
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From£39 total
Average 3.5 /5 Hotel Reviews Call BookMore Details
American Inn in Paducah 5125 Cairo Rd., Paducah, KY 42001 Call ~28.02 miles east of Cairo
  • Two-star hotel
  • 2 floors in property
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From£32 total
Very good 4.0 /5 Read Reviews Call BookMore Details
Hampton Inn & Suites Paducah 3901 Coleman Crossing Circle, Paducah, KY 42001 Call ~28.02 miles east of Cairo
  • 3-star Highway hotel
  • 4 floors in property
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From£69 total
Very good 4.5 /5 Latest Reviews Call BookMore Details
Holiday Inn Express Hotel & Suites Paducah West by IHG 3996 Hinkleville Rd., Paducah, KY 42001 Call ~28.04 miles east of Cairo
  • Three Star Highway hotel
  • Free comp. breakfast
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From£70 total
Average 3.0 /5 Recent Reviews Call BookMore Details
Spark by Hilton in Paducah 3994 Hinkleville Rd., Paducah, KY 42001 Call ~28.05 miles east of Cairo
  • 3 star Airport hotel
  • 3 floors in property
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From£70 total
Very good 4.0 /5 Reviews Call BookMore Details
Courtyard by Marriott Paducah - Paducah 3835 Technology Dr., Paducah, KY 42001 Call ~28.29 miles east of Cairo
  • 3 star Suburban property
  • 100 rooms in hotel
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From£78 total
Very good 4.0 /5 Guest Reviews Call BookMore Details
Days Inn by Wyndham Paducah I-24 Exit 4 3901 Hinkleville Rd., Paducah, KY 42001 Call ~28.75 miles east of Cairo
  • Cheap Highway hotel
  • 32 suites in hotel
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From£44 total
Average 3.0 /5 Review Score Call BookMore Details
Candlewood Suites Cape Girardeau by IHG 485 South Mount Auburn Rd., Cape Girardeau, MO 65703 Call ~28.76 miles northwest of Cairo
  • Economical Highway hotel
  • Hotel has a green policy See policy
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From£61 total
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Travelers Inn and Suites 2550 Lone Oak Rd., Paducah, KY 42003 Call ~28.88 miles east of Cairo
  • Economical property
  • 2 floors in hotel
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From£33 total
Very good 4.0 /5 Read Reviews Call BookMore Details
Quality Inn & Suites Metropolis I-24 in Metropolis 2118 East 5th St., Metropolis, IL 62960 Call ~28.88 miles east of Cairo
  • Mid-scale property
  • Hotel has 52 rooms
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From£70 total
Very good 4.0 /5 Recent Reviews Call BookMore Details
Super 8 by Wyndham Metropolis 2055 East 5th St., Metropolis, IL 62960 Call ~28.89 miles east of Cairo
  • Low-priced Highway hotel
  • 2 floors in property
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From£53 total
Average 3.0 /5 Guest Reviews Call BookMore Details
Motel 6 Metropolis Il : 2119 East 5th St. 2119 East 5th St., Metropolis, IL 62960 Call ~29.04 miles east of Cairo
  • Low priced property
  • Check in time: 11:00 AM
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From£53 total
Average 3.0 /5 Guest Reviews Call BookMore Details
Holiday Inn Express Metropolis by IHG in Metropolis 2179 East 5th St., Metropolis, IL 62960 Call ~29.10 miles east of Cairo
  • 3 star Rural property
  • Complimentary breakfast is offered
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From£57 total
Very good 4.0 /5 Guest Reviews Call BookMore Details
Hampton Inn Cape Girardeau I 55 East in Cape Girardeau 207 South Mount Auburn Rd., Cape Girardeau, MO 63703 Call ~29.41 miles northwest of Cairo
  • 3-star Highway property
  • Check-in time: 3:00 pm
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From£70 total
Excellent 5.0 /5 Hotel Reviews Call BookMore Details
Victorian Inn & Suites : 3256 William St. 3256 William St., Cape Girardeau, MO 63703 Call ~29.41 miles northwest of Cairo
  • Affordable Golf Course property
  • Hotel has 2 floors
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From£69 total
Average 3.0 /5 Read Reviews Call BookMore Details
Auburn Place Hotel & Suites 3265 Williams St., Cape Girardeau, MO 63702 Call ~29.42 miles northwest of Cairo
  • 3-star Highway property
  • Hotel has 5 suites
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From£51 total
Very good 4.5 /5 Review Score Call BookMore Details
Holiday Inn Express & Suites Cape Girardeau I 55 by Ihg in Cape Girardeau 3253 William St., Cape Girardeau, MO 63701 Call ~29.49 miles northwest of Cairo
  • Affordable property
  • Gym / Fitness Center Available
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From£70 total
Very good 4.5 /5 Review Score Call BookMore Details
Fairfield Inn & Suites Cape Girardeau 433 Cape West Crossing, Cape Girardeay, MO 63703 Call ~29.58 miles northwest of Cairo
  • Three Star hotel
  • Free breakfast available
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From£70 total
Average 3.0 /5 Recent Reviews Call BookMore Details
Drury Lodge in Cape Girardeau 104 South Vantage Dr., Cape Girardeau, MO 63701 Call ~29.82 miles northwest of Cairo
  • Midscale Highway property
  • Free breakfast
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From£70 total
Average 3.0 /5 Latest Reviews Call BookMore Details
Quality Inn Cape Girardeau North - Cape Girardeau 2011 North Kingshighway St., Cape Girardeau, MO 63701 Website Call ~31.37 miles northwest of Cairo
  • Cheap hotel
  • Hotel has 2 suites
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From£53 total
Very good 4.0 /5 Latest Reviews Call BookMore Details
Hotel 7 Inn Anna in Anna 100 Richview Dr., Anna, IL 62906 Call ~31.39 miles north of Cairo
  • Two star property
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From£53 total
Very good 4.0 /5 Guest Reviews Call BookMore Details

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Verified reviews of the city: Cairo, IL

Below are reviews of the city of Cairo, IL from an actual visitor's perspective.

"Spending time with my family"
Score 5.0 / 5

Vincent R., from 26-Jan-2026
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