| 1. Candlewood Suites Extended Stay | The Candlewood Suites Extended Stay is an attractive 2-Star hotel located about 1.5 miles west of South Main and approx. a 3 minute drive or uber ride. Travelers gave this hotel a verified guest score of 4/5. | 4 /5 Guest Reviews |
| 2. Holiday Inn Houston N R G Park Area | The Holiday Inn Houston N R G Park Area is a well-liked 3 star hotel located about 1.6 miles north of South Main and about a 3 min. drive by car. With a guest review score of 3.5 out of 5, this makes it one of the most desirable hotel options near South Main. | 3.5 /5 Guest Reviews |
| 3. Carefree Inn at the Medical Center | The Carefree Inn at the Medical Center is an in demand 2-Star hotel located approx. 1.7 miles west of South Main and approx. a 3 minute drive. Travelers gave this hotel an avg. guest review rating of 4/5. | 4 /5 Guest Reviews |
| 4. Extended Stay Deluxe Houston Medical Center La Con | The Extended Stay Deluxe Houston Medical Center La Con is an attractive 2 star hotel located about 1.7 miles north of South Main and about a 3 min. car ride. With a guest review score of 4.5 out of 5, this makes it one of the premium hotel options near South Main. | 4.5 /5 Guest Reviews |
| 5. Holiday Inn Express & Suites Houston S Medical Center Area | The Holiday Inn Express & Suites Houston S Medical Center Area is a well-liked 2 star hotel located about 1.7 miles northwest of South Main and about a 3 min. drive by car. Recent guests gave this hotel an average guest review rating of 5 out of 5. | 5 /5 Guest Reviews |